WO2022171175A1 - Lentille ophtalmique pour prévenir la myopie ou ralentir la progression de la myopie - Google Patents

Lentille ophtalmique pour prévenir la myopie ou ralentir la progression de la myopie Download PDF

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Publication number
WO2022171175A1
WO2022171175A1 PCT/CN2022/075849 CN2022075849W WO2022171175A1 WO 2022171175 A1 WO2022171175 A1 WO 2022171175A1 CN 2022075849 W CN2022075849 W CN 2022075849W WO 2022171175 A1 WO2022171175 A1 WO 2022171175A1
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Prior art keywords
ophthalmic lens
power
myopia
lens
specified power
Prior art date
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PCT/CN2022/075849
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English (en)
Chinese (zh)
Inventor
沙伊尔苏海
肖真
蓝卫忠
费鲍姆克莱斯
白玉婧
Original Assignee
菲特兰有限公司
珠海菲特兰医疗科技有限公司
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Publication of WO2022171175A1 publication Critical patent/WO2022171175A1/fr

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    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G02C7/041—Contact lenses for the eyes bifocal; multifocal
    • G02C7/044—Annular configuration, e.g. pupil tuned
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/06—Lenses; Lens systems ; Methods of designing lenses bifocal; multifocal ; progressive
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/24—Myopia progression prevention

Definitions

  • the present disclosure relates to ophthalmic lenses, and more particularly, to an ophthalmic lens for preventing the occurrence of myopia or delaying the progression of myopia.
  • the human eye has a complex optical system, including: cornea, anterior chamber (aqueous humor), iris (pupil), vitreous body, retina, etc.
  • aqueous humor anterior chamber
  • iris iris
  • vitreous body retina
  • the human eye can form an inverted image on the retina, in which the ciliary muscle can adjust the focus by changing the curvature of the lens.
  • the optical system of the eye should produce an image that is focused on the retina.
  • an optical disorder commonly known as nearsightedness or farsightedness develops.
  • the eye may also have other vision defects such as astigmatism or higher order optical aberrations such as spherical aberration, coma, and the like.
  • myopia has the potential to develop into high myopia, which is closely associated with the risk of developing various eye diseases such as retinal detachment, cataracts, macular hemorrhage and macular degeneration, glaucoma, etc. 0 to 12 years old is a sensitive period for visual development.
  • the human eye is generally hyperopic, meaning that the axial length of the eyeball is too short relative to its optical power. The axial length of the eyeball increases with age, and its elongation process is controlled by a feedback mechanism commonly referred to as emmetropization.
  • the axis of the eye is controlled by the position of the focal point relative to the retina, but cannot be shortened. Therefore, it has been proposed that the progression of myopic refractive error can be controlled by positioning the focus in front of the retina.
  • CN110068937A discloses an ophthalmic lens having an optically non-coaxial zone for myopia control, the lens comprising a central zone, at least one treatment zone and a transition zone therebetween, the central zone having a central zone for myopia vision Corrected negative power, while the treatment zone minimizes the generation of focus behind the retinal plane of the wearer's eye through positive add power.
  • CN207867163U discloses a myopia control lens with an aspheric surface to form peripheral defocus
  • the lens includes a central optical zone and a peripheral optical zone surrounding the central optical zone, the central optical zone is used to form a clear image on the retina, and
  • the peripheral optical zone has an aspherical outer surface and causes passing light to be imaged at the location of the peripheral out-of-focus image zone in front of the retina of the eye.
  • CN104136964B discloses a multifocal optical lens, which can be used to treat presbyopia or myopia progression.
  • the lens includes a central optical zone and a peripheral optical zone that generate different focal points, respectively providing a central refractive power for distance vision and a peripheral optical zone for near vision. refractive power.
  • the present invention provides a novel ophthalmic lens for preventing myopia or delaying the development of myopia, the lens adopts a center-for-near (CN, center-for-near) design, and its optical zone has a first specified power at the edge , and the optical center of the lens has a second specified power, and the second specified power has a first added power of +1.00D or more relative to the first specified power.
  • CN center-for-near
  • the power of the ophthalmic lens gradually decreases radially from the optical center to the first specified power.
  • the entrance surface of the optical zone is configured to create myopic defocus in front of the retina of the wearer's eye.
  • the first specified power is 0 or a negative power for myopia correction.
  • the first add power is selected from +1.00D to +10.00D, preferably +1.20D to +8.00D, more preferably +1.50D to +6.00D, most preferably +2.00 to +4.00D .
  • the optical zone further includes at least one designated area between the optical center and the edge, the designated area having a third designated power relative to the first designated focus The degree has a second add power, and the second add power is less than the first add power.
  • the gradual decrease is a continuous decrease, a stepped decrease, or a combination thereof.
  • the incident surface of the optical zone is an axisymmetric aspheric surface obtained by rotating one or more continuous conic sections around the optical axis.
  • the e-values of the one or more consecutive conic sections are each independently selected from 0.2 to 1.8, preferably 0.4 to 1.6, more preferably 0.8 to 1.4, and most preferably 1 to 1.2.
  • the ophthalmic lens is a contact or scleral lens, an ophthalmic lens, an intraocular lens, or a corneal inlay.
  • the ophthalmic lens further includes one or more stabilizing features adapted to automatically adjust the ophthalmic lens to a recommended posture under gravity when the ophthalmic lens is worn.
  • the ophthalmic lens of the present invention can form myopia defocusing in front of the retina of the wearer's eyes, and utilizes the dynamic eccentricity and strong myopia defocusing caused by the movement of the lens during wearing, so as to achieve more effective myopia prevention and myopia progression control effects than conventional CD designs. .
  • the ophthalmic lens of the present invention can also provide stronger defocus, so that it is suitable for a wider population.
  • FIG. 1 is a schematic diagram of a lens for preventing the occurrence of myopia and controlling the progression of myopia in the prior art.
  • FIGS 2A to 2C illustrate the working principle of the lens of the present invention.
  • Figures 3A to 3D show the power versus distance curves of the lenses of the present invention.
  • Figure 4 shows the field curvature and MTF curve calculated by the optical simulation software OpticStudio Zemax when contact lenses with different e values are placed on the surface of the model eye Liou & Brenna.
  • Figure 5 shows the field curvature and MTF curve calculated by the optical simulation software OpticStudio Zemax when the contact lenses with different e values are placed on the surface of the model eye Liou & Brenna.
  • Figure 1 shows a schematic diagram of the optical lens disclosed in CN207867163U as a representative example of a prior art design employing peripheral defocus.
  • the optical lens 1 includes a central optical zone 11 and a peripheral optical zone 12, and the negative power of the peripheral optical zone is lower than that of the central optical zone.
  • Light passing through the central optic zone forms a focal point 211 on the retina, resulting in a sharp image, while light passing through the peripheral optic zone forms a focal point 212 in front of the retina.
  • the best focusing surface formed by light incident at different field angles is called the Petzval surface.
  • myopic defocusing When the Petzval surface is in front of the retina, it is called myopic defocusing, and vice versa, it is hyperopic defocusing.
  • myopic defocusing When the Petzval surface is in front of the retina, it is called myopic defocusing, and vice versa, it is hyperopic defocusing.
  • myopic defocusing it is believed that the formation of peripheral myopia and defocus can control the development of myopia, while the formation of peripheral hyperopic defocus may promote the progression of myopia.
  • FIG. 2A schematically illustrate the working principle of the lens of the present invention.
  • the optical power of the optical zone gradually decreases in the radial direction from the center of the lens, thereby forming a peripheral progressive curved surface in front of the retina, and this progressive peripheral curved surface is reasonable vision and competition to create conditions to stimulate the peripheral retina to produce myopia and defocus, so as to achieve the purpose of slowing down or even improving the progress of myopia.
  • the accommodative reflex controls the pupillary constriction, and the pupillary contraction increases the focal depth of the eye, thereby making the wearer less than the prescribed optical power.
  • the central area of the lens of the present invention plays a major role.
  • the far point of adjustment is near, so there is no need to use too much adjustment force, so the lens of the present invention can effectively relieve visual fatigue.
  • the pupil becomes larger to collect more reflected light to see clearly, and the light passing through the peripheral part of the lens of the present invention can enter the human eye.
  • the inventors have found that providing optical power at the periphery of the pupil for correcting nearsighted vision is sufficient for the wearer to see distant objects.
  • the design of the ophthalmic lens of the present invention also takes into account the influence of the movement of the lens in front of the eye on its optical imaging, and applies this offset to improve the prevention and control effect of myopia.
  • the inventors found that when the lens of the present invention is located in the middle of the eye, the optimal imaging plane forms a negative field curvature myopic defocus in front of the retina (FIG. 2B).
  • the main zoom area is still within the pupil area, and continues to act on the imaging light, forming a strong peripheral defocus of the retina, especially a stronger negative field curvature on one side, that is, Stronger peripheral myopic defocus, while partial regions on the other side may produce positive field curvature, but this positive field curvature is located farther in the peripheral retina (Fig. 2C).
  • Blink-induced lens movement causes such myopic defocus areas to dynamically sweep across the retina. Frequently changing dynamic myopic defocuses randomly and intermittently stimulate the peripheral retina, and neural adaptations will slow (or even prevent) axial growth.
  • an ophthalmic lens with a CN design as described in the present invention will have better myopia prevention and control effects than a CD lens.
  • prevention refers to inhibiting or preventing the occurrence of myopia, including pseudo-myopia and true myopia.
  • retardation refers to slowing down the rate of myopia progression so that it is lower than the average rate of myopia progression in the same age group.
  • 3A to 3D schematically show the change curves of the power of the lens of the present invention with distance, wherein the abscissa represents the distance from the optical center of the lens, and the ordinate represents the power.
  • the diameter of the optical zone is 7mm (3.5mm on the left and right of the center of the lens), and the lens has a prescription power of -3.0D, but the present invention is not limited to this, for example, taking a contact lens as an example, its The diameter of the optical zone may be 4 to 8 mm.
  • the power of the optical zone of the ophthalmic lens of the present invention gradually decreases radially from the center of the lens.
  • the gradual decrease indicates that the power does not have a raised peak as it changes from center to edge.
  • the gradual decrease is a continuous decrease (FIG. 3A).
  • the gradual decrease is a stepped decrease (FIG. 3C).
  • the gradual decrease is a combination of a continuous decrease and a stepped decrease (FIGS. 3B and 3D).
  • the power can be continuously changed by means of weighted average, but this is not required.
  • the continuous multifocal design enhances the spherical aberration compared to the single focus lens, and a certain degree of spherical aberration can increase the depth of focus and the depth of field. And this increase in focal depth is different before and after the retina.
  • the MTF decreases faster, and the neural adaptation will slow down the growth of the retina in this direction, thereby slowing down the growth of the eye axis.
  • some multifocal designs in the prior art use annular refraction multifocal technology or diffractive multifocal technology. Such technical solutions may cause sudden changes in optical power or surface morphology of the lens, resulting in scattering or scatter in the abrupt region.
  • the ophthalmic lens of the present invention its optic zone has a first specified power at the edge.
  • the first specified power is a negative power for myopia correction.
  • the first specified power is zero.
  • the term "at the edge" includes the outer edge of the optic zone and a region extending radially inwardly from the outer edge of the optic zone a distance, which in the case of a contact lens may be, for example, 1.5 inwardly extending Distances within mm, for example extending inwardly by 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4 or 1.5 mm.
  • the lens has a negative power for myopia correction in an area approximately 1.5 mm from the edge of the optic zone.
  • the entrance surface of the optical zone is configured to create myopic defocus in front of the retina of the wearer's eye.
  • the multifocal lens design with central vision is often used for vision correction of presbyopia, so it pays more attention to the energy distribution of different focal points at near vision and distance vision and the imaging quality at near vision and distance vision, It does not emphasize that the incident light in the optical zone forms myopia and defocus in front of the retina.
  • the optical center of the lens has a second specified power.
  • the term "optical center” or “center” includes both a center point and a center region.
  • the central zone may have a radius of less than 0.2 mm, less than 0.4 mm, less than 0.6 mm, less than 0.8 mm, less than 1.0 mm, less than 1.2 mm or less than 1.5 mm, for example having a radius of 0.1, 0.2, Radius of 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4 or 1.5 mm ( Figure 3C and 3D).
  • the second specified power has a first add power of +1.00D or more with respect to the first specified power.
  • the first add power is less than +10.00D.
  • the first add power is selected from +1.20D to +8.00D.
  • the first add power is selected from +1.50D to +6.00D.
  • the first add power is selected from +2.00 to +4.00D.
  • the first add power is +2.75D.
  • the present invention may also add one or more specified powers between the first specified power and the second specified power. Adding multiple progressive power regions can make the lens of the present invention have better adaptability, and can further optimize MTF and negative field curvature. Accordingly, in some embodiments, the lens also includes at least one additional specified power between the optical center and the edge of its optic zone, the additional specified power having the first specified power relative to the first specified power Two add powers, and the second add power is less than the first add power (FIGS. 3B and 3D).
  • the incident surface of the optical zone is an axisymmetric aspheric surface, and the aspheric surface is obtained by rotating one or more continuous conic curves around the optical axis.
  • the e-values of the one or more continuous conic sections are each independently selected from 0.2 to 1.8, preferably 0.4 to 1.6, more preferably 0.8 to 1.4, and most preferably 1 to 1.2.
  • a specified power may also be used to refer to a lens location or area having the specified power.
  • an area other than 2.5mm from the center of the lens can be the first specified power; within the range of 1.5mm to 2.5mm from the center of the lens, the first specified power can pass through
  • the aspheric surface gradually changes to the third specified power, and its e value is e1; within the range of 1.0mm to 1.5mm from the center of the lens, from the third specified power to the fourth specified power through the aspheric surface, its e value is e2; in the range of 0-1.0mm from the center of the lens, from the fourth specified power to the second specified power through the aspheric surface, the e value is e3; e1, e2 and e3 can be the same or different from each other.
  • the first specified power is a negative power for myopia correction, such as -5.00D
  • the second specified power (lens center) is -2.00D (ie, the first additional power is +3.00D)
  • the third specified power is -4.00D
  • the fourth specified power is -3.00D.
  • Figure 4 shows the field curvature and MTF curve calculated by the optical simulation software OpticStudio Zemax when contact lenses with different e values are placed on the surface of the model eye Liou & Brenna. It shows the variation of field curvature (left column) and MTF (right column) for different e values in CN lenses.
  • the central power is uniformly set to -3D unchanged, but the peripheral is prescribed power (focusing with peripheral light) and the contact lens is designed for continuous progressive focus.
  • the field curvature (including the meridional field curvature (solid line) and the sagittal field curvature (dotted line)) gradually moves to the negative direction.
  • the degree to which the field curvature moves in the direction of negative value is the degree of nearsightedness and defocusing.
  • Conic -0.8 or less, both the meridional field curvature and the sagittal field curvature are negative and continue to move in the negative direction.
  • the low-frequency part of MTF reflects the transmission of object outlines; the intermediate-frequency part reflects the optical object-level transmission; the high-frequency part reflects the transmission of object details.
  • the MTF gradually decreases, especially the high-frequency part decreases, that is, the imaging quality gradually decreases.
  • Figure 5 shows the field curvature and MTF curves calculated by the optical simulation software OpticStudio Zemax when contact lenses with different e values are placed on the surface of the model eye Liou & Brenna. It shows the variation of field curvature (left column) and MTF (right column) for different e values in CD lenses. Among them, the central power is also set to -3D unchanged, and the center is the prescription power (focusing with the central light).
  • the meridional field curvature gradually moves to the negative direction, and the sagittal field curvature moves very slowly.
  • the lens of the present invention has a wider range of e-value options, and the negative field curvature is more obvious, and both the meridional field curvature and the sagittal field curvature have Obvious negative field curvature. Because human eyes may have various differences, a stronger negative field curvature can cover more people.
  • the shape of the back surface of the lens of the present invention is not particularly limited, and it may take any one or a combination of spherical, aspherical, toric, or inverse geometric designs.
  • the back surface of the lenses of the present invention is spherical.
  • the posterior surfaces of the lenses of the present invention have axes in different directions, and the curvatures vary across the axes.
  • the lenses of the present invention further include one or more stabilizing features adapted to automatically adjust the ophthalmic lens to a recommended posture under gravity when worn.
  • the lens designs of the present invention may also be used in scleral lenses, spectacle lenses, intraocular lenses or corneal inlays, and the like.
  • the lens of the present invention was tested for retardation of myopia progression in a pilot study consisting of 8 myopic patients.
  • the patients had an average age of 15.5 years and used contact lenses with a base arc radius of 8.6 mm and a diameter of 14.5 mm.
  • the lenses used had an average spherical power of -4.22D and an average add power of +2.75D in the central optical zone.
  • the patient wears the lens of the present invention every day, checks every 3 months and replaces the new lens. After wearing for one year, no patient has the situation of deepening myopia.
  • the average spherical refractive power of the lens used is still -4.22D, and the average BCVA 0.125LogMAR, the same as when the experiment started. According to the literature, the average annual progression of myopia is -0.75D.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Eyeglasses (AREA)
  • Rehabilitation Tools (AREA)

Abstract

L'invention concerne une lentille ophtalmique pour prévenir la myopie ou ralentir la progression de la myopie. La lentille ophtalmique a une région optique, et la région optique a une première puissance spécifiée au niveau d'un bord et une seconde puissance spécifiée au niveau d'un centre optique, la seconde puissance spécifiée ayant une première puissance supplémentaire supérieure à +1,00 D par rapport à la première puissance spécifiée. Une telle lentille ophtalmique peut former une défocalisation de myopie devant les yeux d'un utilisateur, et peut améliorer la défocalisation de la myopie en utilisant l'excentricité dynamique provoquée par le mouvement de la lentille pendant le port, ce qui permet de mettre en œuvre une prévention efficace de la myopie et une régulation de la progression.
PCT/CN2022/075849 2021-02-10 2022-02-10 Lentille ophtalmique pour prévenir la myopie ou ralentir la progression de la myopie WO2022171175A1 (fr)

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CN202110183145.X 2021-02-10
CN202110183145.XA CN114911071B (zh) 2021-02-10 2021-02-10 用于预防近视或延缓近视发展的眼科镜片

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CN115407525A (zh) * 2022-08-30 2022-11-29 北京天明眼科新技术开发公司 离焦镜片及离焦眼镜
CN115951507A (zh) * 2022-12-01 2023-04-11 北京同仁医学科技有限责任公司 一种可减少散射光的渐变式离焦近视防控镜片
CN116699871A (zh) * 2023-05-29 2023-09-05 江苏全真光学科技股份有限公司 一种多点离焦变色眼镜片及其制备方法
WO2023221085A1 (fr) * 2022-05-20 2023-11-23 菲特兰有限公司 Lentille ophtalmique ayant une position d'addition de clé

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US20010033363A1 (en) * 2000-01-14 2001-10-25 Nicolas Chateau Pair of ophthalmic lenses, range of ophthalmic lenses and method for prescribing a pair of ophthalmic lenses
US20020044255A1 (en) * 2000-08-17 2002-04-18 Ming Ye Lens design to enhance vision quality
CN101688983A (zh) * 2007-05-21 2010-03-31 庄臣及庄臣视力保护公司 防止近视发展的眼用透镜
CN101784943A (zh) * 2007-08-22 2010-07-21 诺瓦提斯公司 老花眼治疗系统
CN105445959A (zh) * 2014-08-29 2016-03-30 庄臣及庄臣视力保护公司 用于预防和/或减慢近视发展的自由曲面镜片设计和方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023221085A1 (fr) * 2022-05-20 2023-11-23 菲特兰有限公司 Lentille ophtalmique ayant une position d'addition de clé
CN115407525A (zh) * 2022-08-30 2022-11-29 北京天明眼科新技术开发公司 离焦镜片及离焦眼镜
CN115407525B (zh) * 2022-08-30 2023-10-17 北京天明眼科新技术开发公司 离焦镜片及离焦眼镜
CN115951507A (zh) * 2022-12-01 2023-04-11 北京同仁医学科技有限责任公司 一种可减少散射光的渐变式离焦近视防控镜片
CN115951507B (zh) * 2022-12-01 2023-08-18 北京同仁医学科技有限责任公司 一种可减少散射光的渐变式离焦近视防控镜片
CN116699871A (zh) * 2023-05-29 2023-09-05 江苏全真光学科技股份有限公司 一种多点离焦变色眼镜片及其制备方法
CN116699871B (zh) * 2023-05-29 2023-11-10 江苏全真光学科技股份有限公司 一种多点离焦变色眼镜片及其制备方法

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