WO2022171126A1 - Composé cyclique fusionné utilisé comme inhibiteur de wee-1 - Google Patents
Composé cyclique fusionné utilisé comme inhibiteur de wee-1 Download PDFInfo
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- WO2022171126A1 WO2022171126A1 PCT/CN2022/075655 CN2022075655W WO2022171126A1 WO 2022171126 A1 WO2022171126 A1 WO 2022171126A1 CN 2022075655 W CN2022075655 W CN 2022075655W WO 2022171126 A1 WO2022171126 A1 WO 2022171126A1
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- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- halogen
- heterocycloalkyl
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- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
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- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 239000011975 tartaric acid Substances 0.000 description 1
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- 229960001367 tartaric acid Drugs 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000000101 thioether group Chemical group 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
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- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- UAEJRRZPRZCUBE-UHFFFAOYSA-N trimethoxyalumane Chemical compound [Al+3].[O-]C.[O-]C.[O-]C UAEJRRZPRZCUBE-UHFFFAOYSA-N 0.000 description 1
- 229950002929 trinitrophenol Drugs 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne un composé cyclique fusionné utilisé en tant qu'inhibiteur de Wee-1. Plus particulièrement, la présente invention concerne un composé représenté par la formule générale (1) et un procédé de préparation associé, ainsi qu'une utilisation du composé de formule générale (1) et d'isomères, de formes cristallines, d'hydrates, de solvates ou de sels pharmaceutiquement acceptables de ceux-ci en tant qu'inhibiteurs de Wee-1 dans la préparation d'un médicament antitumoral.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202280012622.9A CN116848117A (zh) | 2021-02-09 | 2022-02-09 | 作为Wee-1抑制剂的稠环化合物 |
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CN202110179656.4 | 2021-02-09 | ||
CN202110179656 | 2021-02-09 | ||
CN202110757479.3 | 2021-07-05 | ||
CN202110757479 | 2021-07-05 |
Publications (1)
Publication Number | Publication Date |
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WO2022171126A1 true WO2022171126A1 (fr) | 2022-08-18 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/CN2022/075655 WO2022171126A1 (fr) | 2021-02-09 | 2022-02-09 | Composé cyclique fusionné utilisé comme inhibiteur de wee-1 |
Country Status (2)
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CN (1) | CN116848117A (fr) |
WO (1) | WO2022171126A1 (fr) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101432284A (zh) * | 2006-04-27 | 2009-05-13 | 万有制药株式会社 | 二氢吡唑并嘧啶酮衍生物 |
EP2213673A1 (fr) * | 2007-10-23 | 2010-08-04 | Banyu Pharmaceutical Co., Ltd. | Dérivé de dihydropyrazolopyrimidinone substitué par pyridone |
WO2018011569A1 (fr) * | 2016-07-12 | 2018-01-18 | Almac Discovery Limited | Composés de pyrazolopyrimidinone inhibant la wee -1 |
WO2019037678A1 (fr) * | 2017-08-24 | 2019-02-28 | 上海迪诺医药科技有限公司 | Dérivé de pyrazolo[3,4-d]pyrimidin-3-one, composition pharmaceutique et utilisation associée |
WO2019074979A1 (fr) * | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | Composés hétérocycliques et leurs utilisations |
CN111718348A (zh) * | 2019-03-22 | 2020-09-29 | 首药控股(北京)有限公司 | Wee1抑制剂及其制备和用途 |
CN111902413A (zh) * | 2018-03-09 | 2020-11-06 | 里科瑞尔姆Ip控股有限责任公司 | 取代的1,2-二氢-3H-吡唑并[3,4-d]嘧啶-3-酮 |
-
2022
- 2022-02-09 WO PCT/CN2022/075655 patent/WO2022171126A1/fr active Application Filing
- 2022-02-09 CN CN202280012622.9A patent/CN116848117A/zh active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101432284A (zh) * | 2006-04-27 | 2009-05-13 | 万有制药株式会社 | 二氢吡唑并嘧啶酮衍生物 |
EP2213673A1 (fr) * | 2007-10-23 | 2010-08-04 | Banyu Pharmaceutical Co., Ltd. | Dérivé de dihydropyrazolopyrimidinone substitué par pyridone |
WO2018011569A1 (fr) * | 2016-07-12 | 2018-01-18 | Almac Discovery Limited | Composés de pyrazolopyrimidinone inhibant la wee -1 |
WO2019037678A1 (fr) * | 2017-08-24 | 2019-02-28 | 上海迪诺医药科技有限公司 | Dérivé de pyrazolo[3,4-d]pyrimidin-3-one, composition pharmaceutique et utilisation associée |
WO2019074979A1 (fr) * | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | Composés hétérocycliques et leurs utilisations |
CN111902413A (zh) * | 2018-03-09 | 2020-11-06 | 里科瑞尔姆Ip控股有限责任公司 | 取代的1,2-二氢-3H-吡唑并[3,4-d]嘧啶-3-酮 |
CN111718348A (zh) * | 2019-03-22 | 2020-09-29 | 首药控股(北京)有限公司 | Wee1抑制剂及其制备和用途 |
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