WO2022148842A1 - Vitrectomy device - Google Patents
Vitrectomy device Download PDFInfo
- Publication number
- WO2022148842A1 WO2022148842A1 PCT/EP2022/050275 EP2022050275W WO2022148842A1 WO 2022148842 A1 WO2022148842 A1 WO 2022148842A1 EP 2022050275 W EP2022050275 W EP 2022050275W WO 2022148842 A1 WO2022148842 A1 WO 2022148842A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inner tube
- outer tube
- vitrectomy
- opening
- vitrectomy device
- Prior art date
Links
- 238000000034 method Methods 0.000 claims abstract description 13
- 238000005520 cutting process Methods 0.000 claims description 112
- 239000000463 material Substances 0.000 claims description 11
- 239000000975 dye Substances 0.000 claims description 3
- 229940023490 ophthalmic product Drugs 0.000 claims description 3
- 230000002207 retinal effect Effects 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 5
- 239000000835 fiber Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
- A61F9/00763—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments with rotating or reciprocating cutting elements, e.g. concentric cutting needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
- A61B2017/00544—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated pneumatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2217/00—General characteristics of surgical instruments
- A61B2217/002—Auxiliary appliance
- A61B2217/005—Auxiliary appliance with suction drainage system
Definitions
- the present invention relates to ophthalmic surgical devices, systems, and methods, in particular to vitrectomy device with a rotating inner tube.
- Microsurgical procedures frequently require precision cutting and/or removing of various body tissues.
- vitrectomy devices are made of an immobile outer tube with an opening on the side and an inner tube that moves up and down working as a guillotine knife to cut the vitreous (vertical cutters).
- the innertube movement is typically a pneumatically driven spring-return system and maximal cutting speeds of about 10.000 cuts per minute can be obtained with this technology.
- dual cutting ports have been invented, effectively doubling cutting speed and maintaining a 100% open duty cycle (opening of the cutter port) increasing flow capacity and decreasing particle size of the vitreous material. This however does not suffices to perform a traction free vitrectomy.
- An ophthalmic surgical system may include a vitrectomy probe having a housing sized and shaped for grasping by a user.
- the vitrectomy probe may also include a cutter extending from the housing and being sized to penetrate and treat a patient eye.
- the cutter may include an outer cutting tube coupled to the housing.
- the outer cutting tube may have an outer port formed therein that is sized and shaped to receive tissue.
- the cutter may include a rotatable inner cutting member disposed within the outer cutting tube.
- the inner cutting member may include a first cutting surface that rotates across the outer port to cut the tissue when the inner cutting member is rotated.
- the vitrectomy probe may include a pneumatic vane actuator positioned within the housing and configured to rotate the inner cutting member.
- a disadvantage of this invention is that the device is used only for cutting or aspiration and excludes multifunctional use.
- WO2018178804 discloses vitrectomy probes and methods related thereto are disclosed herein.
- the disclosure describes various example vitrectomy probes having a rotational helical cutter.
- An example helical cutter includes an outer cutter portion and an inner cutter portion received therewithin.
- the inner cutter portion is operable to rotationally reciprocate within the outer cutter portion about a longitudinal axis thereof.
- a helical shearing surface formed at a distal end of the inner cutter portion is operable to sever material entering the cutter via a port formed in the outer cutter portion.
- a disadvantage of this invention is that the device is used only for cutting or aspiration and excludes multifunctional use.
- the present invention provides for a vitrectomy device comprising a housing and a cutter, wherein the cutter comprising an outer tube coupled to the housing, an inner tube disposed within the outer tube, the inner tube is rotatable about a longitudinal axis thereof, a drive system positioned within the housing is coupled to the inner tube and configured to rotate the inner tube, the inner tube comprises at least one opening with at least one cutting edge at the wall of the inner tube at the distal end of said inner tube, the outer tube comprises an opening with a cutting edge at the wall of the outer tube at the distal end of said outer tube, characterized in that the inner tube comprises a plurality of openings with a plurality of cutting edges at the wall of the inner tube at the distal end of said inner tube, the cutting edges of the inner tube and the cutting edge of the outer tube are configured to form an angle with respect to one another by rotation of the inner tube.
- the inner tube has a plurality of cutting edges spaced from one another, configured to create a variable open surface opening during rotation in the overlap between the opening of the outer tube and the plurality of openings of the inner tube.
- the inner tube is configured to create contact between the cutting edges of the outer tube and the cutting edges of the inner tube at any time during the rotation of the inner tube.
- variable open surface of opening is between 50-150% of a diameter of the outer tube.
- the drive system of the cutter of the vitrectomy device comprises a motor, a drive shaft and a revolving cylinder.
- the inner tube is removable.
- the revolving cylinder of the drive system of the cutter comprises multiple chambers, wherein at least one of said chambers holds the inner tube.
- the revolving cylinder of the drive system of the cutter may further comprise a vitrectomy tool selected from a flute needle, a soft tipped needle / retinal dyes / intra- ocular medication.
- the motor is selected from a pneumatically driven sterilizable air- motor with high-speed rotation of at least 80.000 rpm or an electric motor with high-speed rotation of at least 80.000 rpm.
- the outer tube is open at the distal end.
- At least one cutting edge of the opening of the inner tube is vertical. In a following embodiment, at least one cutting edge of the opening of the inner tube is oblique.
- the opening of the outer tube is not restricted to a particular shape.
- the opening of the outer tube is substantially (semi)-circular.
- the cutting edge of the opening of the outer tube is substantially (semi)-circular.
- the inner tube is configured as an aspiration passageway arranged to aspirate tissue from the eye.
- the present invention provides a method of a vitrectomy using a vitrectomy device according to any one of the previous claims comprising the steps of inserting the vitrectomy device into a vitreous cavity of the eye; turning-on a drive system of the cutter of the vitrectomy device to rotate the inner tube of the cutter of the vitrectomy device; cutting the vitreous material by the cutter, - removing vitreous material from said vitreous cavity by aspiration; characterized in that the cutting is achieved by an angle formed between the cutting edges of the inner tube and the cutting edge of the outer tube.
- the inner tube has a plurality of cutting edges spaced from one another, creating a variable aspiration space, i.e. creating a variable open surface opening, during rotation in the overlap between the opening of the outer tube and at least one opening of the inner tube.
- Fig. 1a is a side view of a schematic representation of the direction of the incisions of the vitreous material.
- Fig. 2 is a side view of a vitrectomy device, according to an embodiment of the present invention.
- Fig. 3A is a side view of an outer tube of a vitrectomy device, according to an embodiment of the present invention.
- Fig. 3B is a side view of an inner tube of a vitrectomy device, according to an embodiment of the present invention.
- Fig. 4 is a side view of a vitrectomy device, according to an embodiment of the present invention.
- Fig. 5 is a side view of a vitrectomy device, according to an embodiment of the present invention.
- Fig. 6 shows a detailed side view of a distal end of a cutter, according to an embodiment of the present invention.
- distal end is to be understood as the end located away from the center of the device along a longitudinal axis of said device.
- the term “distal” can be generally understood in the field to mean away from the surgeon's side of the apparatus and close to the patient's side.
- the term “revolving” is to be understood as something that moves around a longitudinal axis thereof.
- the term “removable” is to be understood as something that can easily be moved from its place or position.
- drive system is to be understood as a system that drives the internal parts of a vitrectomy device, e.g. gives rotation to revolving cylinder and/or the inner tube.
- vitrectomy tools may be used in one vitrectomy device to perform not only cutting but also other vitrectomy procedures, what increases the speed of the vitrectomy operation.
- cutting edge is constantly active due to the respective configuration and the location of the cutting edges of the inner and the outer tubes.
- the vitrectomy device has a continuous open aspiration port due to the respective configuration and the location of the cutting edges of the inner and the outer tubes.
- FIG 1 showing a side view of a schematic representation of the direction of the cuts 115 of the vitreous material, represented schematically in the form of fibers 116.
- This figure clearly shows that the vitreous material is not cut along the fiber 116, as when using vertical cutters with horizontal cutting edges, and not across the fiber 116, as when using rotary cutters with vertical cutting edges, but the cut 115 extends at an angle to the surface of the fiber 116 in several places (locations).
- the vitrectomy device 100 comprises an outer tube 103 and an inner tube 106 (indicated also by a dotted line) with openings at their walls.
- the outer tube 103 has an opening 104 at its distal end.
- the outer tube 103 has the opening 104 at its wall and is closed at its end.
- the outer tube 103 can be open at its end.
- the shape of the opening 104 is at least substantially semi-circular and the cutting edge 105 of the outer tube 103 is also at least substantially semi-circular.
- the opening 104 can be substantially circular.
- the cutting edge 105 can be also substantially circular.
- the term “semi-circular” should be understood as an object or arrangement of objects in the form of a half circle. For example, when a circle is cut into two halves or when the circumference of a circle is divided by 2, we get semi-circular shape.
- the term “(semi)-circular” is meant to include both semi-circular and circular arrangements.
- Substantially semi-circular and substantially circular indicates that the shape is not restricted to semi-circles or circles but includes any overall round - semi-round shape, such as an (semi)-oval, (semi)-egg shape, (semi)-ellipsoid, and the like.
- the inner tube 106 comprises a plurality of openings 107 with a plurality of cutting edges 108 at the wall of the inner tube 106 at the distal end of said inner tube 106.
- the inner tube 106 is closed at the distal end.
- the cutting edges 108 of the openings 107 of the rotating inner tube 106 are oblique with respect to the longitudinal axis LA of said inner tube.
- Fig. 3A illustrates a separate side view of an outer tube 103 of a vitrectomy device 100 with a semi-circular cutting edge 105, according to an embodiment of the present invention.
- Fig. 3B illustrates a separate side view of an inner tube 103 of a vitrectomy device 100, according to an embodiment of the present invention. This figure clearly shows that the inner tube comprises a plurality of openings 107 with a plurality of cutting edges 108 at the wall of the inner tube 106.
- FIG 4 showing a side view of a vitrectomy device 100, according to an embodiment of the present invention.
- the vitrectomy device 100 comprises an outer tube 103 and an inner tube 106 (indicated also by a dotted line) with openings at their walls.
- the outer tube 103 has an opening 104 at its distal end.
- the opening 104 is semi-circular and the cutting edge 105 of the outer tube 103 is also semicircular.
- the inner tube comprises a plurality of openings 107 with a plurality of cutting edges 108 at the wall of the inner tube 106 at the distal end of said inner tube 106.
- the opening 107 between the cutting edges 108 can be of different widths.
- the theoretical advantage of this embodiment is that by aligning the largest opening 107 of the inner tube 106 with the opening 104 in the outer tube 103, a larger flow rate can be achieved by merely applying suction without cutting.
- the inner tube 106 is closed at the distal end.
- the cutting edge 108 of the opening 107 of the rotating inner tube 106 is oblique with respect to the longitudinal axis (LA) of said inner tube.
- the vitrectomy device 100 comprises a housing 101 , that is sized and shaped for grasping by a hand of a user, and a cutter 102, configured for insertion into the eye of a patient.
- the cutter 102 extends from a distal portion 114 of the housing 101 along a longitudinal axis (LA).
- the cutter 102 comprises an outer tube 103 coupled to and extending from the housing 101 .
- the outer tube 103 has an opening 104 on the wall at the distal end.
- the outer tube 103 is complete open at the distal end.
- the outer tube 103 is closed at the distal end.
- the cutter 102 comprises further an inner tube 106 disposed within the outer tube 103, the inner tube 106 is rotatable about a longitudinal axis thereof, which in this implementation, is coaxial with the longitudinal axis LA.
- the inner tube 106 and outer tube 103 fit together tightly.
- the inner tube 106 comprises at least one opening 107 with at least one cutting edge 108 at the wall of the inner tube 106 at the distal end of said inner tube 106.
- the inner tube 106 comprises a plurality of openings 107 with a plurality of cutting edges 108 at the wall of the inner tube 106 at the distal end of said inner tube 106.
- the plurality cutting edges 108 of the inner tube 106 are spaced from one another.
- the inner tube 106 is configured to create a variable open surface of the opening 104 during rotation in the overlap between the opening 104 of the outer tube 103 and the plurality of openings 107 of the inner tube 106.
- at least one cutting edge 108 of the opening 107 of the rotating inner tube 106 may be vertical, i.e. along or oblique with respect to the longitudinal axis of the inner tube Alternatively all of the cutting edges 108 of the plurality of openings 107 of the rotating inner tube 106 may be parallel with one another, along or oblique with respect to the longitudinal axis of the inner tube.
- at least one cutting edge 108 of the opening 107 of the rotating inner tube 106 may be slightly curved, i.e.
- all of the cutting edges 108 of the plurality of openings 107 of the rotating inner tube 106 may be slightly curved, i.e. smoothly rounded with respect to the longitudinal axis of the inner tube, in particular in a parallel orientation to one another. Said vertical and/or slightly curved orientations of the cutting edges 108 of the openings107 of the rotating inner tube 106 improve the cutting movement.
- the plurality of the cutting edges 108 of the opening 107 of the inner tube 106 is oblique with respect to the longitudinal axis of the inner tube.
- the outer tube 103 comprises an opening 104 with a cutting edge 105 at the wall of the outer tube 103 at the distal end of said outer tube 103.
- the opening 104 of the outer tube 103 is semi-circular; in particular the cutting edge 105 of the outer tube 103 is semi-circular.
- the opening 104 can be substantially circular.
- the cutting edge 105 can be also substantially circular.
- the inner tube 106 of the cutter 102 is in an extreme position characterized by the fact that the distal end of the inner tube 106 does not extend beyond the distal end of the outer tube 103, and therefore the cutting edges 108 of the inner tube 106 and the cutting edge 105 of the outer tube 103 form an angle a (shown in fig.
- the inner tube 106 is configured to create contact, i.e. form the angle a, between the cutting edges 105 of the outer tube 103 and at least one of the cutting edges 108 of the inner tube 106 at any time during the rotation of the inner tube 106.
- the plurality of openings 107 with a plurality of cutting edges 108 at the wall of the inner tube 106 are preferably configured to create contact between the cutting edges 105 of the outer tube 103 and at least one of the cutting edges 108 of the inner tube 106 at any turning position of the inner tube with respect to the outer tube.
- Such configuration provides cutting conditions at any turning position, enabling a continuous cutting at any time during the rotation of the inner tube 106.
- the distance between the openings 107 in the inner tube 106 and/or the orientation of the cutting edges 108 can allow such a continuous cutting at any time of the rotation of the inner tube 106.
- the openings 107 are arranged in such a way that at least two cutting edges 108 of the inner tube 106 form an angle a with respect to the cutting edge 105 of the outer tube 103. Therefore, the continuous cutting is achieved by two cuttings with every rotation of the inner tube 106.
- the angle a is variable and is between 90° at the beginning of the cutting, when the cutting edge 108 of the inner tube 106 first contacts the cutting edge 105 of the outer tube 103, and 180° at the end of the cutting, when the cutting edge 108 of the inner tube 106 touches the last point of the cutting edge 105 of the outer tube 103, since the cutting follows the shape of the opening 104.
- the cutting edges 108 of the plurality of openings 107 of the rotating inner tube 106 are parallelly spaced from one another in an oblique or slightly curved orientation, and the cutting edge 105 of the outer tube 103 is substantially (semi)-circular, wherein the openings 107 are arranged in such a way that at least two cutting edges 108 of the inner tube 106 form an angle a with respect to the cutting edge 105 of the outer tube 103. It has been observed that such a configuration provides the best result in cutting and fast aspiration of fibrous vitreous material as it is being pulled towards the aspiration passageway of the inner tube 106.
- the inner tube 106 is removable.
- the vitrectomy device 100 comprises further a drive system 109 positioned within the housing 101 , the drive system 109 coupled to the inner tube 106 and configured to rotate the inner tube 106.
- the drive system 109 of the cutter 102 comprises a motor 110, a drive shaft 111 and a revolving cylinder 112.
- the revolving cylinder 112 of the drive system 109 of the cutter 102 comprises multiple chambers 113, located symmetrically about its longitudinal axis. In this example the revolving cylinder 112 comprises four chambers 113, wherein one of said chambers 113 holds the inner tube 106.
- the revolving cylinder 112 may further comprise a vitrectomy tool selected for example from a flute needle, a soft tipped needle / retinal dyes / intra-ocular medication etc.
- the inner tube 106 may be replaced with this vitrectomy tool in the outer tube 103 to perform other surgical procedures.
- the motor 110 of the drive system 109 is for example selected from a pneumatically driven sterilizable air-motor with high-speed rotation of at least 80.000 rpm or an electric motor with high-speed rotation of at least 80.000 rpm.
- the plurality of cutting edges 108 of the inner tube 106 spaced from one another creates a variable aspiration space during rotation in the overlap between the opening 104 of the outer tube 103 and the openings 107 of the inner tube 106.
- the variable open surface of the opening 104 is between 50-150% of a diameter of the outer tube 103.
- the inner tube 106 is an aspiration passageway arranged to aspirate tissue from the eye.
- FIG 6 showing a detailed side view of a distal end of a cutter 102, according to an embodiment of the present invention.
- the inner tube 106 comprises a plurality of openings 107 with a plurality of cutting edges 108 at the wall of the inner tube 106 at the distal end of said inner tube 106 and that the plurality of the cutting edges 108 of the opening 107 of the rotating inner tube 106 is oblique with respect to the longitudinal axis of the inner tube.
- the cutting edges 108 of the inner tube 106 and the cutting edge 105 of the outer tube 103 form an angle a with respect to one another by rotation of the inner tube 106.
- the method of a vitrectomy using a vitrectomy device 100 is carried out as follows.
- the vitrectomy device 100 inserts into a vitreous cavity of the eye.
- a drive system of the cutter 102 of the vitrectomy device 100 turns on to rotate the inner tube 106 of the cutter 102 of the vitrectomy device.
- the vitreous material is cut by the cutter 102 and then is removed from said vitreous cavity by aspiration.
- the cutting is achieved by an angle a formed between the cutting edges 108 of the inner tube 106 and the cutting edge 105 of the outer tube 103.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202280015293.3A CN116887793A (en) | 2021-01-07 | 2022-01-07 | Vitrectomy device |
US18/260,431 US20240065890A1 (en) | 2021-01-07 | 2022-01-07 | Vitrectomy device |
EP22700063.5A EP4274528A1 (en) | 2021-01-07 | 2022-01-07 | Vitrectomy device |
JP2023541534A JP2024506796A (en) | 2021-01-07 | 2022-01-07 | vitrectomy device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21150592 | 2021-01-07 | ||
EP21150592.0 | 2021-01-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022148842A1 true WO2022148842A1 (en) | 2022-07-14 |
Family
ID=74141380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2022/050275 WO2022148842A1 (en) | 2021-01-07 | 2022-01-07 | Vitrectomy device |
Country Status (5)
Country | Link |
---|---|
US (1) | US20240065890A1 (en) |
EP (1) | EP4274528A1 (en) |
JP (1) | JP2024506796A (en) |
CN (1) | CN116887793A (en) |
WO (1) | WO2022148842A1 (en) |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013009576A1 (en) * | 2011-07-08 | 2013-01-17 | Doheny Eye Institute | Ocular lens cutting device |
US20140171997A1 (en) * | 2012-12-18 | 2014-06-19 | Alcon Research, Ltd. | Multi-Port Vitrectomy Probe with Dual Cutting Edges |
US20170333252A1 (en) * | 2016-05-17 | 2017-11-23 | Novartis Ag | Vitrectomy probe with end tissue cutter and associated devices, systems, and methods |
WO2018011699A2 (en) | 2016-07-11 | 2018-01-18 | Novartis Ag | Vitrectomy probe with rotary cutter and associated devices, systems, and methods |
WO2018178804A1 (en) | 2017-03-27 | 2018-10-04 | Novartis Ag | Vitrectomy probe with rotational helical cutter |
DE102017221017A1 (en) * | 2017-11-24 | 2019-05-29 | Geuder Ag | Device for cutting and aspirating tissue from the human or animal eye |
US20190314201A1 (en) * | 2018-04-11 | 2019-10-17 | Alcon Inc. | Vitrectomy instrument with multiple rotating cutting edges |
ES2777881A1 (en) * | 2020-02-25 | 2020-08-06 | Weyezer Solutions Sl | VITRECTOMY PROBE (Machine-translation by Google Translate, not legally binding) |
-
2022
- 2022-01-07 JP JP2023541534A patent/JP2024506796A/en active Pending
- 2022-01-07 CN CN202280015293.3A patent/CN116887793A/en active Pending
- 2022-01-07 WO PCT/EP2022/050275 patent/WO2022148842A1/en active Application Filing
- 2022-01-07 EP EP22700063.5A patent/EP4274528A1/en active Pending
- 2022-01-07 US US18/260,431 patent/US20240065890A1/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013009576A1 (en) * | 2011-07-08 | 2013-01-17 | Doheny Eye Institute | Ocular lens cutting device |
US20140171997A1 (en) * | 2012-12-18 | 2014-06-19 | Alcon Research, Ltd. | Multi-Port Vitrectomy Probe with Dual Cutting Edges |
US20170333252A1 (en) * | 2016-05-17 | 2017-11-23 | Novartis Ag | Vitrectomy probe with end tissue cutter and associated devices, systems, and methods |
WO2018011699A2 (en) | 2016-07-11 | 2018-01-18 | Novartis Ag | Vitrectomy probe with rotary cutter and associated devices, systems, and methods |
WO2018178804A1 (en) | 2017-03-27 | 2018-10-04 | Novartis Ag | Vitrectomy probe with rotational helical cutter |
DE102017221017A1 (en) * | 2017-11-24 | 2019-05-29 | Geuder Ag | Device for cutting and aspirating tissue from the human or animal eye |
US20190314201A1 (en) * | 2018-04-11 | 2019-10-17 | Alcon Inc. | Vitrectomy instrument with multiple rotating cutting edges |
ES2777881A1 (en) * | 2020-02-25 | 2020-08-06 | Weyezer Solutions Sl | VITRECTOMY PROBE (Machine-translation by Google Translate, not legally binding) |
Also Published As
Publication number | Publication date |
---|---|
EP4274528A1 (en) | 2023-11-15 |
CN116887793A (en) | 2023-10-13 |
JP2024506796A (en) | 2024-02-15 |
US20240065890A1 (en) | 2024-02-29 |
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