WO2022135649A1 - Dispositif d'inhalation et procédé d'exécution d'inhalation - Google Patents

Dispositif d'inhalation et procédé d'exécution d'inhalation Download PDF

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Publication number
WO2022135649A1
WO2022135649A1 PCT/EA2020/050006 EA2020050006W WO2022135649A1 WO 2022135649 A1 WO2022135649 A1 WO 2022135649A1 EA 2020050006 W EA2020050006 W EA 2020050006W WO 2022135649 A1 WO2022135649 A1 WO 2022135649A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
aerosol generation
inhalation
processing
data
Prior art date
Application number
PCT/EA2020/050006
Other languages
English (en)
Russian (ru)
Inventor
Олег Раджабович АБДИЕВ
Андрей Геннадьевич ОГИЕНКО
Original Assignee
Общество с ограниченной ответственностью "Научно-производственный Инновационный внедренческий центр"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество с ограниченной ответственностью "Научно-производственный Инновационный внедренческий центр" filed Critical Общество с ограниченной ответственностью "Научно-производственный Инновационный внедренческий центр"
Publication of WO2022135649A1 publication Critical patent/WO2022135649A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators

Definitions

  • the technical solution relates to the field of medicine, in particular, to a device and method for carrying out an inhalation procedure, which ensures the stability of the characteristics of the generated aerosol throughout the entire inhalation procedure.
  • an inhalation device including a communication means that allows data exchange with a personal computer to control the conduct of inhalation, a drug chamber, an aerosol generation mechanism with a grid, and a gas flow channel.
  • the device also includes sensors for recording inhalations and exhalations for the purpose of subsequent correction of aerosol generation and instructing patients to conduct an effective inhalation procedure.
  • a technical solution is known, selected as the closest analogue, which is an inhalation device for delivering a sprayed aerosol to a patient, containing an aerosol generator with a vibration mesh, a reservoir for the liquid to be sprayed, which is in fluid communication with the vibration mesh, and a gas flow channel.
  • the device also includes a base unit including an electronic controller for controlling the aerosol generator, wherein the operation of the aerosol generator includes continuous vibration of the vibrating grid.
  • the liquid to be sprayed enters the device immediately by pouring into the tank.
  • Distinctive features of the proposed solution are: the execution of the processor unit for processing and transmitting data associated with the database, the presence of a compartment for loading the cartridge with the liquid to be sprayed, the content of the liquid presence sensor and the tilt angle sensor associated with the processor unit for processing and transmitting data.
  • the effectiveness of the inhalation procedure is due, in particular, to the economical consumption of the drug and the achievement of the maximum amount of active medicinal substances delivered to the patient, with the possibility of controlling the dose of such substances, by stopping the generation of aerosol or notifying the patient in case of incorrect operation of the inhalation device and the possibility of adjusting the inhalation parameters depending on external source data.
  • the inhalation device contains a processing unit for receiving, processing and transmitting data, an aerosol generation module, including a housing, a reservoir for placing a liquid to be sprayed in it, configured to be connected to a node for installing a mesh membrane, and an aerosol generation mechanism , configured to actuate the mesh membrane, connected to the processor unit for processing and transmitting data, while the processor unit for receiving, processing and transmitting data is connected to the database, the housing contains a compartment for loading a cartridge with a liquid to be sprayed into it, in the housing contains a liquid presence sensor and an inclination angle sensor connected to the processor unit for processing and transmitting data.
  • an aerosol generation module including a housing, a reservoir for placing a liquid to be sprayed in it, configured to be connected to a node for installing a mesh membrane, and an aerosol generation mechanism , configured to actuate the mesh membrane, connected to the processor unit for processing and transmitting data, while the processor unit for receiving, processing and transmitting data is connected to the database
  • the housing
  • the housing may contain a sensor for measuring the flow rate and/or a differential pressure gauge associated with the processing unit for data processing and transmission.
  • the inhalation device may include a patient identification device and a cartridge identification device connected to the data processing unit, while the data acquisition processing unit is configured to determine whether the drug and dose match the patient and issue an appropriate command to the aerosol generation mechanism.
  • a device for heating the liquid to be sprayed can be installed in the housing.
  • a liquid temperature sensor can be installed in the housing.
  • the sufficiency of the volume of liquid for generating an aerosol in the reservoir is determined by means of a liquid presence sensor, data is obtained from the angle sensor slope, send a signal to start aerosol generation to the aerosol generation mechanism, receive data from a sensor for measuring the flow rate and/or a differential pressure gauge, determine data on breathing parameters by means of a processor unit for processing and transmitting data, and implementing algorithms for stopping generation by a processor unit for processing and transmitting data depending on on the indicators of the sensors, in which, when fixing the fact of the presence of a deviation of the inhalation device at an angle exceeding the allowable for stable generation of aerosol and / or the absence of liquid in the reservoir, a signal is sent to the aerosol generation mechanism to stop the generation of aerosol or a signal informing about the incorrect operation of the device, to based on the parameters of respiration, the beginning of the next breath of the patient is predicted and a signal about the beginning of aerosol generation is sent to the aerosol generation mechanism,
  • the sufficiency of the volume of liquid for inhalation can be further determined by the cartridge identification device based on information read from a machine-readable label placed on the cartridge.
  • the parameters of the liquid to be sprayed can be determined by means of a cartridge identification device based on information read from a machine-readable label placed on the cartridge.
  • the liquid to be sprayed can be heated by means of a device for heating the liquid, while the temperature of the liquid is regulated to the temperature optimal for spraying by means of a processing unit for processing and transmitting data that receives data on the temperature of the liquid determined by the temperature sensor liquid and transmitting the appropriate signals to the device for heating the liquid.
  • the liquid presence sensor and the tilt angle sensor installed in the housing, connected to the processing unit for processing and transmitting data, provide registration of the fact of the inclined position of the device or the absence of medicine in the reservoir. This function allows you to control the correct operation of the device in in accordance with its technical characteristics, spraying stability at acceptable tilt angles, spraying off at an unacceptable tilt angle.
  • the execution of the processing unit for processing and transmitting data associated with the database allows you to adjust the parameters of the inhalation procedure, stop or prevent its implementation, depending on the external initial data stored in the database, such as information about the patient, drug, indicators of the mesh membrane and etc.
  • the compartment for loading the cartridge with the liquid to be sprayed eliminates the need to manually deliver the drug to the reservoir, which ensures maximum consumption of the liquid to be sprayed during inhalation.
  • the identification device installed in the housing provides the ability to obtain data on the drug loaded into the cartridge, such as name, volume, etc., contained on the cartridge label.
  • the execution of the processor unit for receiving, processing and transmitting data connected to the database with the possibility of identifying the patient by means of the identification device, allows you to determine the correspondence between the prescription of the drug and the patient, to allow or prohibit the procedure.
  • a sensor for measuring the flow rate and/or a differential pressure gauge installed in the body and connected to the processing unit for processing and transmitting data make it possible to control the generation of an aerosol and to calculate and control the flow rate of doses of the liquid to be sprayed, depending on the parameters of the patient's breathing. Intermittent generation allows you to calculate the exact dose of the drug taken by the patient during one breath. Another advantage of intermittent generation is the absence of condensate on the walls of the inhalation tube and the patient's face.
  • the inhalation device may include a device for heating the liquid to be sprayed, allowing you to control the quality of the generated aerosol, depending on the instructions for the corresponding inhalation procedure.
  • the liquid heated to optimal temperatures cooled by cool inlet air, passes into condensate to a lesser extent, but on the contrary, evaporates, while the small drops formed in the full amount of the required dose penetrate the patient's respiratory tract.
  • some types of drugs have viscous consistency at room temperature, hindering efficient aerosol generation.
  • the inhalation device advantageously includes a liquid temperature sensor for adjusting the optimum temperature of the inhaled drug.
  • a liquid temperature sensor for adjusting the optimum temperature of the inhaled drug.
  • FIG. 1 shows a general view of the inhalation device.
  • FIG. 1 shows an inhalation device (1) with a processing unit (2) for receiving, processing and transmitting data and an aerosol generation module (3).
  • the inhalation device (1) contains a processor unit (2) for receiving, processing and transmitting data associated with a remote or local database.
  • the processing unit (2) for receiving, processing and transmitting data is equipped with software containing information about prescribed procedures, parameters of medicines used in procedures, data on procedures performed, etc.
  • the inhalation device (1) also includes an aerosol generation module (3), which includes a housing containing a compartment for loading a cartridge with a liquid to be sprayed into it, a reservoir for accommodating liquid coming from the cartridge, configured to be connected to a unit for installing a mesh membranes and an aerosol generation mechanism configured to actuate the mesh membrane, connected to the processing unit (2) for receiving, processing and transmitting data.
  • an aerosol generation module (3) which includes a housing containing a compartment for loading a cartridge with a liquid to be sprayed into it, a reservoir for accommodating liquid coming from the cartridge, configured to be connected to a unit for installing a mesh membranes and an aerosol generation mechanism configured to actuate the mesh membrane, connected to the processing unit (2) for receiving, processing and transmitting data.
  • the housing contains a liquid presence sensor and an inclination angle sensor connected to the processing unit (2) for receiving, processing and transmitting data.
  • the tilt angle sensor can be made in the form of an electronic gyroscope.
  • the housing also contains a sensor for measuring the flow rate and/or a differential pressure gauge connected to the processing unit (2) for receiving, processing and transmitting data.
  • a device for heating the liquid to be sprayed and a liquid temperature sensor can be installed in the housing.
  • the inhalation device (1) includes a patient identification device and a drug identification device connected to the processing unit (2) for receiving, processing and transmitting data, while the processing unit (2) for receiving, processing and transmitting data is configured to determine the compliance of the drug means and doses with the patient, and giving the appropriate command to the aerosol generation mechanism.
  • the processing unit (2) for receiving, processing and transmitting data can be equipped with a fingerprint scanner, with which the patient is identified from the list of prescribed procedures.
  • the inhalation device (1) can also be equipped with means for ionizing the sprayed aerosol so that its drops do not stick together and deposit less on the mouthpiece and mask used with the inhalation device (1).
  • the method of inhalation is carried out as follows.
  • the inhalation procedure After insertion and opening of the liquid cartridge, and also, preferably, after identification and comparison of the medicinal product with the patient, the inhalation procedure is started.
  • the presence of deviation of the inhalation device (1) at an angle exceeding the allowable for stable generation of aerosol is fixed, and data on breathing parameters are determined by means of a processor unit (2) for receiving, processing and transmitting data.
  • the adequacy of the volume of liquid for inhalation may further be determined by the cartridge identification device based on information read from a machine-readable label placed on the cartridge.
  • parameters of the liquid to be sprayed are determined by means of a cartridge identification device based on information read from a machine-readable label placed on the cartridge.
  • the liquid to be sprayed is heated by means of a liquid heating device, while the liquid temperature is regulated to the temperature optimal for spraying by means of a processor unit (2) for receiving, processing and transmitting data, receiving data on the temperature of the liquid, determined by the temperature sensor of the liquid and transmitting the corresponding signals to the device for heating the liquid.
  • the processing unit (2) for receiving, processing and transmitting data implements algorithms for stopping generation depending on the indicators of the sensors and sends signals to start or stop aerosol generation to the aerosol generation mechanism.
  • Aerosol generation occurs at the moment of inhalation and stops at the moment of exhalation. This measures the exact volume of the active substance received by the patient in the form of an aerosol based on data on the characteristics of the generated aerosol and data on breathing parameters and/or the duration of inhalation and exhalation in real time. After receiving statistics on the breathing profile, a forecast of the beginning and end of inspiration is performed.
  • the claimed technical solution can be used in medicine, in particular, as a device for carrying out an inhalation procedure for respiratory therapy of a wide range of diseases in adults and children.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif d'inhalation comprenant une unité de processeur reliée à une base de données, un module de génération d'aérosol comprenant un corps, un réservoir de liquide à pulvériser venant se connecter à une unité d'installation d'une membrane réticulée, et un mécanisme de génération d'aérosol. Le corps comprend une section de chargement de cartouche, des capteurs de présence de liquide et d'angle d'inclinaison, de mesure de vitesse de flux et/ou un dynamomètre et/ou un dispositif de chauffage de liquide et/ou un capteur de température de liquide. Lors de la réalisation d'une inhalation, on détermine la quantité nécessaire du volume de liquide, on obtient des données depuis le capteur d'angle d'inclinaison, on envoie un signal de début de génération d'aérosol, on obtient des données depuis le capteur de mesure de vitesse de flux et/ou du dynamomètre, on détermine des données sur les paramètres de respiration, et on exécute des algorithmes de génération d'aérosol.
PCT/EA2020/050006 2020-12-25 2020-12-29 Dispositif d'inhalation et procédé d'exécution d'inhalation WO2022135649A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EA202092905 2020-12-25
EA202092905 2020-12-25

Publications (1)

Publication Number Publication Date
WO2022135649A1 true WO2022135649A1 (fr) 2022-06-30

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PCT/EA2020/050006 WO2022135649A1 (fr) 2020-12-25 2020-12-29 Dispositif d'inhalation et procédé d'exécution d'inhalation

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WO (1) WO2022135649A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117679591A (zh) * 2023-12-27 2024-03-12 华中科技大学同济医学院附属同济医院 一种雾化系统及其控制方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016048435A1 (fr) * 2014-09-22 2016-03-31 Qualcomm Incorporated Inhalateur avec capteur d'orientation
WO2016049066A1 (fr) * 2014-09-23 2016-03-31 Oscillari Llc Capteur de vibrations à base d'un dispositif de surveillance de l'administration de médicaments
RU2707892C2 (ru) * 2015-09-01 2019-12-02 Аир Лтд Система электронного испарителя
RU2709926C2 (ru) * 2014-12-05 2019-12-23 Джуул Лэбз, Инк. Контроль калиброванной дозы

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016048435A1 (fr) * 2014-09-22 2016-03-31 Qualcomm Incorporated Inhalateur avec capteur d'orientation
WO2016049066A1 (fr) * 2014-09-23 2016-03-31 Oscillari Llc Capteur de vibrations à base d'un dispositif de surveillance de l'administration de médicaments
RU2709926C2 (ru) * 2014-12-05 2019-12-23 Джуул Лэбз, Инк. Контроль калиброванной дозы
RU2707892C2 (ru) * 2015-09-01 2019-12-02 Аир Лтд Система электронного испарителя

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117679591A (zh) * 2023-12-27 2024-03-12 华中科技大学同济医学院附属同济医院 一种雾化系统及其控制方法
CN117679591B (zh) * 2023-12-27 2024-04-26 华中科技大学同济医学院附属同济医院 一种雾化系统及其控制方法

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