WO2022130531A1 - 生体電極およびキャパシタ - Google Patents
生体電極およびキャパシタ Download PDFInfo
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- WO2022130531A1 WO2022130531A1 PCT/JP2020/046941 JP2020046941W WO2022130531A1 WO 2022130531 A1 WO2022130531 A1 WO 2022130531A1 JP 2020046941 W JP2020046941 W JP 2020046941W WO 2022130531 A1 WO2022130531 A1 WO 2022130531A1
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- Prior art keywords
- film
- hydrogel
- bioelectrode
- capacitor
- water
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- 239000003990 capacitor Substances 0.000 title claims description 49
- 239000000017 hydrogel Substances 0.000 claims abstract description 68
- 239000000463 material Substances 0.000 claims abstract description 35
- 230000001681 protective effect Effects 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000012528 membrane Substances 0.000 claims abstract description 27
- 239000000499 gel Substances 0.000 claims abstract description 19
- 230000036760 body temperature Effects 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 239000005871 repellent Substances 0.000 claims abstract description 8
- 230000008859 change Effects 0.000 claims description 37
- 108010010803 Gelatin Proteins 0.000 claims description 16
- 239000008273 gelatin Substances 0.000 claims description 16
- 229920000159 gelatin Polymers 0.000 claims description 16
- 235000019322 gelatine Nutrition 0.000 claims description 16
- 235000011852 gelatine desserts Nutrition 0.000 claims description 16
- 229920001661 Chitosan Polymers 0.000 claims description 15
- 229920006254 polymer film Polymers 0.000 claims description 11
- 230000008595 infiltration Effects 0.000 claims description 5
- 238000001764 infiltration Methods 0.000 claims description 5
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 4
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 4
- 235000013871 bee wax Nutrition 0.000 claims description 3
- 239000012166 beeswax Substances 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 230000007704 transition Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009545 invasion Effects 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 11
- 238000010521 absorption reaction Methods 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000010931 gold Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000000560 biocompatible material Substances 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000014121 butter Nutrition 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229920001940 conductive polymer Polymers 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 229920005597 polymer membrane Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000003075 superhydrophobic effect Effects 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000003501 hydroponics Substances 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002120 nanofilm Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/277—Capacitive electrodes
Definitions
- the present invention relates to bioelectrodes and capacitors using biocompatible materials.
- Non-Patent Document 1 and Non-Patent Document 2 exist as examples of capacitors using biocompatible materials.
- the purpose of these studies is to change the capacitance according to the pressure and pH in the body.
- the change in capacitance uses the change in the dielectric constant between the plates or the distance between the plates, and the conductive material and the dielectric material are all composed of biocompatible materials that are harmless in the body.
- Patent Document 1 using a gel exists, and a two-layer structure of a conductive layer and a gel layer is proposed.
- a gel to which sugar or salt is added is used for the electrode substrate, but in this configuration, if water is absorbed in contact with body fluid such as gastric juice, there is a concern that the electrode may be destroyed due to swelling of the gel or the like. .. On the other hand, using materials that are too difficult to break down in the body can affect the digestive process.
- the conventional technique cannot produce a capacitor that operates properly in the body.
- the purpose is to collect information in a specific place such as the stomach, small intestine, or large intestine
- the life of the capacitor cannot be controlled by the conventional technique, and the operation at a desired position cannot be guaranteed. Occurs.
- the present invention has been made to solve the above problems, and an object of the present invention is to enable the production of a capacitor that operates properly in the body.
- the bioelectrode according to the present invention has a first material that undergoes a solgel change at a temperature within a predetermined range centered on the body temperature of the living body and is compatible with the living body, and a second material that does not cause a solgel change at the temperature and is compatible with the living body. Suppresses the infiltration of water into the hydrogel membrane, which is composed of a mixture of and, which is compatible with living organisms, the conductive film formed on one surface of the hydrogel membrane, and the hydrogel membrane formed on the other surface of the hydrogel membrane. It is provided with a protective film.
- the capacitor according to the present invention uses the above-mentioned two bioelectrodes.
- the present invention comprises a mixture of a first material that causes a sol-gel change at a temperature within a predetermined range centered on the body temperature of a living body and a second material that does not cause a sol-gel change at a temperature. Since a protective film that suppresses the infiltration of water into the hydrogel film is formed on the other surface of the hydrogel film, a capacitor that operates properly in the body can be produced.
- FIG. 1 is a configuration diagram showing a configuration of a bioelectrode according to an embodiment of the present invention.
- FIG. 2A is an explanatory diagram illustrating a change in the hydrogel film 101 actually produced depending on the temperature.
- FIG. 2B is an explanatory diagram illustrating a change in the hydrogel film 101 actually produced depending on the temperature.
- FIG. 2C is an explanatory diagram illustrating a change in the hydrogel film 101 actually produced depending on the temperature.
- FIG. 2D is an explanatory diagram illustrating a change in the hydrogel film 101 actually produced depending on the temperature.
- FIG. 2E is an explanatory diagram illustrating a change in the hydrogel film 101 actually produced depending on the temperature.
- FIG. 2A is an explanatory diagram illustrating a change in the hydrogel film 101 actually produced depending on the temperature.
- FIG. 2B is an explanatory diagram illustrating a change in the hydrogel film 101 actually produced depending on the temperature.
- FIG. 2C is an explanatory diagram illustrating
- FIG. 3A is an explanatory diagram illustrating the relationship between the temperature and the hydrogel film 101.
- FIG. 3B is an explanatory diagram illustrating the relationship between the temperature and the hydrogel film 101.
- FIG. 4A is a photograph showing changes in the bioelectrode submerged in water at 40 ° C.
- FIG. 4B is a photograph showing changes in the bioelectrode submerged in water at 20 ° C.
- FIG. 5 is a photograph of a bioelectrode actually produced.
- FIG. 6 is a photograph showing the water-repellent state of the protective film.
- FIG. 7A is a configuration diagram showing a configuration of a capacitor according to an embodiment of the present invention.
- FIG. 7B is a photograph showing the appearance of the actually manufactured capacitor.
- FIG. 8A is a cross-sectional photograph showing a state of a polymer film arranged between two bioelectrodes constituting a capacitor.
- FIG. 8B is a cross-sectional photograph showing the state of the polymer film arranged between the two bioelectrodes constituting the capacitor.
- FIG. 8C is a cross-sectional photograph showing a state of a polymer film arranged between two bioelectrodes constituting a capacitor.
- FIG. 9A is a characteristic diagram showing an example of a measurement result using the capacitor according to the embodiment.
- FIG. 9B is a characteristic diagram showing an example of a measurement result using the capacitor according to the embodiment.
- FIG. 10 is a perspective view showing the configuration of another capacitor according to the embodiment.
- FIG. 11 is a perspective view showing the configuration of another capacitor according to the embodiment.
- the bioelectrode is composed of a hydrogel film 101, a conductive film 102, and a protective film 103.
- a conductive film 102 is formed on one surface of the hydrogel film 101, and a protective film 103 is formed on the other surface of the hydrogel film 101.
- the hydrogel membrane 101 comprises a first material that undergoes a solgel change at a temperature within a predetermined range centered on the body temperature of the living body and is compatible with the living body, and a second material that does not cause the solgel change at the above temperature and is compatible with the living body. It is composed of a mixture and is suitable for living organisms.
- the first material can be gelatin and the second material can be chitosan.
- the first material can be a material having a melting point near the body temperature, such as butter, cacao butter, shea butter, and coconut oil.
- the second material may be a material having a slightly high melting point such as agar or agar.
- the conductive film 102 can be, for example, a film (metal film) made of a metal such as Au. Further, the conductive film 102 may be made of a conductive polymer material.
- the protective film 103 is provided to suppress the infiltration of water into the hydrogel film 101.
- the protective film 103 can be made of a waterproof material or a water-repellent material.
- the protective film 103 can be, for example, an insoluble film composed of sodium alginate and calcium chloride, or a water-repellent film composed of beeswax.
- this bioelectrode uses a hydrogel membrane 101 as a support, which is composed of a mixture of a first material that causes a sol-gel change near body temperature and a second material that does not change the sol-gel, the disintegration time in the body is controlled. can do. Further, since the hydrogel film 101 composed of gelatin and chitosan has adhesive strength, a conductive film 102 made of an Au film formed on another substrate (glass substrate) by a sputtering method or the like can be easily placed on the hydrogel film 101. It can be transferred, facilitating the fabrication of bioelectrodes.
- the hydrogel membrane 101 alone swells and easily disintegrates, for example, by absorbing water in the body. Therefore, in the embodiment, the protective film 103 is formed by superimposing the protective film 103 on the hydrogel film 101 to suppress the absorption of water and control the time until the hydrogel film 101 collapses.
- the bioelectrode it is possible to prevent the bioelectrode from being immediately disintegrated in the body. Further, according to the embodiment, the bioelectrode can be in a state of gradually collapsing due to temperature.
- FIG. 2A is a result of observing the state after 1 minute while filling a rectangular parallelepiped cell with an aqueous solution of 25 wt% gelatin, solidifying it at room temperature, laying it on its side, and heating the lower part to 50 ° C.
- FIG. 2B shows the results of observing the state after 1 minute while filling an aqueous solution of 1 wt% chitosan and 24 wt% gelatin in a rectangular parallelepiped cell, solidifying it at room temperature, and then laying it on its side and heating the lower part to 50 ° C.
- FIG. 2C shows the results of observing the state after 1 minute while filling an aqueous solution of 2 wt% chitosan and 23 wt% gelatin in a rectangular parallelepiped cell, solidifying it at room temperature, laying it on its side, and heating the lower part to 50 ° C.
- FIG. 2D shows the results of stuffing an aqueous solution of 3 wt% chitosan and 22 wt% gelatin into a rectangular parallelepiped cell, solidifying it at room temperature, laying it on its side, and observing the state after 1 minute while heating the lower part to 50 ° C.
- FIG. 2C shows the results of observing the state after 1 minute while filling an aqueous solution of 2 wt% chitosan and 23 wt% gelatin in a rectangular parallelepiped cell, solidifying it at room temperature, laying it on its side, and heating the lower part to 50 ° C.
- FIG. 2C shows the results of observing the state after 1
- 2E shows the results of observing the state after 1 minute while filling a rectangular parallelepiped cell with an aqueous solution of 1 wt% chitosan, solidifying it at room temperature, laying it on its side, and heating the lower part to 50 ° C.
- gelatin changes from gel to sol, and while chitosan originally flows out because it is a solution, delay in liquefaction is observed by mixing gelatin and chitosan.
- the dotted line in the figure is the boundary line between the air and the sample. From these results, it can be said that the time for changing from gel to sol can be controlled by the mixing ratio of gelatin and chitosan.
- the change in solgel of gelatin can be quantitatively observed as a change in transmittance (wavelength 550 nm) with temperature, but Chitosan does not change. It can also be seen that the change in transmittance with temperature changes depending on the combination ratio of gelatin and chitosan. For example, in the case of chitosan 2 wt% and gelatin 23 wt%, and in the case of chitosan 1 wt% and gelatin 24 wt%, the ratio of gelatin is large and the gel / sol change can be followed.
- FIGS. 4A and 4B show changes in the bioelectrode submerged in water at 40 ° C.
- FIG. 4B shows changes in the bioelectrode submerged in water at 20 ° C.
- solification causes the hydrogel membrane to shatter into pieces, and the bioelectrode does not retain its initial structure.
- This bioelectrode is formed by transferring a gold film onto a hydrogel film made of gelatin and chitosan. Since the hydrogel film has flexibility, it can be easily peeled off from the glass plate on which the Au film was formed during transfer, and the patterned Au film can also be transferred.
- FIG. 6B is an enlargement of a part of FIG. 6A. Further, in FIG. 6A, 10 ⁇ L of water droplets are shown.
- FIG. 6 shows a cross-sectional view when a superhydrophobic structure made of beeswax is produced as an example of a protective film that suppresses water absorption.
- the hydrogel film absorbs a large amount of water.
- the insolubilizing film is formed as a protective film, the degree of water absorption in the hydrogel film can be suppressed to some extent.
- a water-repellent material or a superhydrophobic material is formed as a protective film, there is an effect of greatly suppressing the absorption of honey in the hydrogel film.
- Such a protective film is used to suppress the destruction of the bioelectrode due to the swelling of the hydrogel film.
- the protective film can be formed only on the other surface of the hydrogel film, and the protective film can be further formed on the surface of the conductive film formed on one of the hydrogel films.
- the conductive film when the conductive film is composed of a conductive polymer, the conductive film absorbs water, cracks are generated in the conductive film, or the conductive film is patterned to form a hydrogel.
- the conductive film When one surface of the film is partially exposed, it is important to form a protective film on the surface of the conductive film as well.
- a protective film is formed only between patterns or in gaps such as cracks.
- a film of a material to be a protective film can be formed only in the above-mentioned gaps by coating with a spotter, coating using the surface charge of a hydrogel film, or the like.
- This capacitor is configured by using the above-mentioned two bioelectrodes.
- the two bioelectrodes By arranging the two bioelectrodes at a distance from each other, it can be used as a capacitor.
- the first bioelectrode 100a and the second bioelectrode 100b are arranged so that the first conductive film 102a and the second conductive film 102b face each other.
- the first conductive film 102a is formed on one surface of the hydrogel film 101a
- the protective film 103a is formed on the other surface of the hydrogel film 101a.
- the second conductive film 102b is formed on one surface of the hydrogel film 101b
- the protective film 103b is formed on the other surface of the hydrogel film 101b.
- a film 104 made of an external stimulus-responsive substance such as a polymer film made of sodium polyacrylate between the first bioelectrode 100a and the second bioelectrode 100b, the first bioelectrode 100a and the second bioelectrode 100a are placed.
- the capacitance can be changed by changing the distance from the bioelectrode 100b.
- Sodium polyacrylate is a polymer material whose volume changes depending on its position in the body due to the difference in osmotic pressure between gastric juice and water. Therefore, the dielectric constant and the thickness of the film 104 change depending on the position in the body, and the capacity of the capacitor can be changed.
- FIG. 7B shows the appearance of a capacitor actually manufactured by using sodium polyacrylate (20 wt%) as the film 104.
- the thickness (t1, t2, t3) of the polymer film arranged between the two bioelectrodes described above changes depending on the environment.
- the thickness t1 (FIG. 8A) of the polymer membrane in the initial capacitor produced becomes as thin as t2 when the capacitor is immersed in artificial gastric juice (FIG. 8B).
- the polymer film becomes as thick as t3 (FIG. 8C).
- FIGS. 9A and 9B a measurement example using the above-mentioned capacitor will be described with reference to FIGS. 9A and 9B.
- a measurement frequency of 1 kHz the change in capacity due to the difference between gastric juice and water and the change in capacity due to the change in pressure applied to the capacitor are shown. Since the volume is measured at a low frequency, the value includes the volume of the solution containing water polarization and ions. Further, it can be seen that after the pressure is applied, the distance between the two bioelectrodes changes due to the restoration of the polymer membrane, and the capacitance approaches the original value.
- the capacitor when the capacitor changes the capacitance from the change in the permittivity between the two bioelectrodes without changing the distance between the two bioelectrodes, the capacitor makes a large difference in the permittivity between air (gas) and water. It can be used.
- C 0 be the capacity when an air layer having a thickness of 99 ⁇ m and a polymer film having a thickness of 1 ⁇ m are arranged between two bioelectrodes.
- the capacity when an air layer having a thickness of 90 ⁇ m and a polymer film having a thickness of 10 ⁇ m are arranged between the two bioelectrodes is defined as C 1 .
- the capacity when a polymer film having a thickness of 100 ⁇ m is placed between the two bioelectrodes is defined as C 2 .
- the permittivity of the polymer film is 5 and the permittivity of water is 80
- the permittivity of the mixture of air and the high-condensed molecular film is calculated from the ratio by the Maxwell- Garnett model.
- ⁇ gel ' 69.5
- the two bioelectrodes are composed of two conductive films 112a and 112b arranged apart from each other on the hydrogel film 111 with the hydrogel film 111 in common.
- a protective film 113 is formed on the back surface side of the hydrogel film 111.
- the distance between the conductive film 112a and the conductive film 112b is 50 ⁇ 10 -9 m.
- the thickness of the conductive film 112a and the conductive film 112b is limited to about 1 ⁇ m.
- the two conductive films 122a and 122b are each formed in the shape of comb teeth, and the comb teeth are alternately inserted and arranged so that the two conductive films are realistic. The distance between the films and the thickness of the conductive film can be designed.
- the capacitor having this configuration can also be detected as a change in capacitance by changing the dielectric constant between the two conductive films.
- the capacitors illustrated in FIGS. 10 and 11 have a structure in which the two conductive films can be brought into direct contact with an external liquid, and therefore, consideration is given to destruction due to swelling of the hydrogel film. It is necessary, but it can be expected to shorten the reaction time.
- a protective film that suppresses the infiltration of water into the hydrogel film is formed on the other surface of the formed hydrogel film, a capacitor that operates properly in the body can be produced.
- the disintegration time in the body can be controlled by using a hydrogel membrane in which a material that causes sol-gel change near body temperature and a material that does not change sol-gel are used.
- water absorption can be suppressed by stacking protective films.
- the bioelectrode can be made to not disintegrate immediately and gradually disintegrate with temperature, and a capacitor can be manufactured using this.
- the capacitor according to the present invention can read the change in resonance frequency from outside the body by magnetic field coupling, and can estimate the state inside the body.
- the application of the present invention is not limited to the body, and since a biodegradable material is used, measurement in water (select an external stimulus-responsive hydrogel membrane, for example, water quality survey, hydroponics, aquaculture, etc.) It can also be used for measuring ions, pH, etc. in the environment).
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Abstract
Description
Claims (8)
- 生体の体温を中心とした所定の範囲の温度でゾルゲル変化を起こし、前記生体に適合する第1材料と、前記温度でゾルゲル変化を起こさない、前記生体に適合する第2材料との混合体から構成され、前記生体に適合するヒドロゲル膜と、
前記ヒドロゲル膜の一方の面に形成された導電膜と、
前記ヒドロゲル膜の他方の面に形成された、前記ヒドロゲル膜への水の滲入を抑制する保護膜と
を備える生体電極。 - 請求項1記載の生体電極において、
前記保護膜は、防水材料または撥水材料から構成されていることを特徴とする生体電極。 - 請求項2項に記載の生体電極において、
前記保護膜は、アルギン酸ナトリウムと塩化カルシウムから構成された不溶化膜、または蜜ロウからなる撥水膜であることを特徴とする生体電極。 - 請求項1~3のいずれか1項に記載の生体電極において、
前記第1材料は、ゼラチンであり、前記第2材料は、キトサンであることを特徴とする生体電極。 - 請求項1~4のいずれかの生体電極を2つ用いたキャパシタ。
- 請求項5記載のキャパシタにおいて、
2つの生体電極は、各々の前記導電膜を向かい合わせて配置され、
2つの生体電極の間に配置されたポリアクリル酸ナトリウムからなる高分子膜を備える
ことを特徴とするキャパシタ。 - 請求項5記載のキャパシタにおいて、
2つの生体電極は、前記ヒドロゲル膜を共通として、前記ヒドロゲル膜の上に離間して配置された2つの前記導電膜から構成されていることを特徴とするキャパシタ。 - 請求項7記載のキャパシタにおいて、
2つの前記導電膜は、各々櫛歯状に形成され、各櫛歯が、交互に入り込んで配置されていることを特徴とするキャパシタ。
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Application Number | Priority Date | Filing Date | Title |
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PCT/JP2020/046941 WO2022130531A1 (ja) | 2020-12-16 | 2020-12-16 | 生体電極およびキャパシタ |
US18/257,799 US20240108269A1 (en) | 2020-12-16 | 2020-12-16 | Bioelectrode and capacitor |
JP2022569392A JP7537515B2 (ja) | 2020-12-16 | 2020-12-16 | キャパシタ |
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JP2015506913A (ja) * | 2011-11-23 | 2015-03-05 | プロテウス デジタル ヘルス, インコーポレイテッド | 保存安定性要素を含む組成物 |
JP2015142754A (ja) * | 2008-08-13 | 2015-08-06 | プロテウス デジタル ヘルス, インコーポレイテッド | 摂取可能デバイスおよびそれを生成する方法 |
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JP2015506913A (ja) * | 2011-11-23 | 2015-03-05 | プロテウス デジタル ヘルス, インコーポレイテッド | 保存安定性要素を含む組成物 |
WO2014162341A1 (ja) * | 2013-04-01 | 2014-10-09 | テルモ株式会社 | 体内水分計、検出装置、それらの制御方法、および記憶媒体 |
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