WO2022129059A1 - Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one citric acid ester - Google Patents
Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one citric acid ester Download PDFInfo
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- WO2022129059A1 WO2022129059A1 PCT/EP2021/085710 EP2021085710W WO2022129059A1 WO 2022129059 A1 WO2022129059 A1 WO 2022129059A1 EP 2021085710 W EP2021085710 W EP 2021085710W WO 2022129059 A1 WO2022129059 A1 WO 2022129059A1
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- alkyl group
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- 239000000203 mixture Substances 0.000 title claims abstract description 141
- 239000002537 cosmetic Substances 0.000 title claims abstract description 30
- DZVCFNFOPIZQKX-LTHRDKTGSA-M merocyanine Chemical compound [Na+].O=C1N(CCCC)C(=O)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 DZVCFNFOPIZQKX-LTHRDKTGSA-M 0.000 title claims abstract description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 title claims description 19
- -1 citric acid ester Chemical class 0.000 title description 100
- 150000002148 esters Chemical class 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 30
- 102000011782 Keratins Human genes 0.000 claims abstract description 23
- 108010076876 Keratins Proteins 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 20
- 230000008569 process Effects 0.000 claims abstract description 17
- 150000001875 compounds Chemical class 0.000 claims description 63
- 239000003795 chemical substances by application Substances 0.000 claims description 48
- 238000012216 screening Methods 0.000 claims description 43
- 229920000642 polymer Polymers 0.000 claims description 35
- 125000004432 carbon atom Chemical group C* 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 22
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 238000002844 melting Methods 0.000 claims description 14
- 230000008018 melting Effects 0.000 claims description 14
- 150000001298 alcohols Chemical class 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 150000003628 tricarboxylic acids Chemical class 0.000 claims description 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 6
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical group OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 6
- 125000001931 aliphatic group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 claims description 4
- 125000002757 morpholinyl group Chemical group 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 3
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 239000000178 monomer Substances 0.000 claims description 3
- 125000005936 piperidyl group Chemical group 0.000 claims description 3
- NPNDSRGIZUPLNP-PEZBUJJGSA-N 2-ethoxyethyl (2z)-2-cyano-2-[3-(3-methoxypropylamino)cyclohex-2-en-1-ylidene]acetate Chemical compound CCOCCOC(=O)C(\C#N)=C1\CCCC(NCCCOC)=C1 NPNDSRGIZUPLNP-PEZBUJJGSA-N 0.000 claims 1
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 abstract description 10
- 230000001225 therapeutic effect Effects 0.000 abstract description 8
- 239000003921 oil Substances 0.000 description 51
- 235000019198 oils Nutrition 0.000 description 50
- 239000012071 phase Substances 0.000 description 50
- 239000000047 product Substances 0.000 description 47
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 45
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 41
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 23
- 239000000049 pigment Substances 0.000 description 23
- 210000003491 skin Anatomy 0.000 description 23
- 229920001296 polysiloxane Polymers 0.000 description 21
- 239000000839 emulsion Substances 0.000 description 20
- 239000002904 solvent Substances 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 239000006185 dispersion Substances 0.000 description 17
- 235000014113 dietary fatty acids Nutrition 0.000 description 15
- 239000000194 fatty acid Substances 0.000 description 15
- 229930195729 fatty acid Natural products 0.000 description 15
- 235000014692 zinc oxide Nutrition 0.000 description 14
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 13
- 229930195733 hydrocarbon Natural products 0.000 description 13
- 150000002430 hydrocarbons Chemical class 0.000 description 13
- 239000011787 zinc oxide Substances 0.000 description 13
- 239000004215 Carbon black (E152) Substances 0.000 description 12
- 239000008346 aqueous phase Substances 0.000 description 12
- 150000004665 fatty acids Chemical class 0.000 description 12
- 239000000377 silicon dioxide Substances 0.000 description 12
- 239000000126 substance Substances 0.000 description 12
- 230000005855 radiation Effects 0.000 description 11
- 239000002245 particle Substances 0.000 description 10
- 150000003254 radicals Chemical class 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 9
- 238000003756 stirring Methods 0.000 description 9
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 8
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- 229920001577 copolymer Polymers 0.000 description 8
- 210000004209 hair Anatomy 0.000 description 8
- 239000011572 manganese Substances 0.000 description 8
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- 239000002585 base Substances 0.000 description 7
- 150000002191 fatty alcohols Chemical class 0.000 description 7
- 229910044991 metal oxide Inorganic materials 0.000 description 7
- 150000004706 metal oxides Chemical class 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 229920002545 silicone oil Polymers 0.000 description 7
- 239000004408 titanium dioxide Substances 0.000 description 7
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 7
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 6
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 239000007983 Tris buffer Substances 0.000 description 6
- 239000000443 aerosol Substances 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 230000003711 photoprotective effect Effects 0.000 description 6
- 229920005862 polyol Polymers 0.000 description 6
- 239000001993 wax Substances 0.000 description 6
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 5
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 5
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 5
- HEAHZSUCFKFERC-IWGRKNQJSA-N [(2e)-2-[[4-[(e)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid Chemical group CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)\C2=C\C(C=C1)=CC=C1\C=C/1C(=O)C2(CS(O)(=O)=O)CCC\1C2(C)C HEAHZSUCFKFERC-IWGRKNQJSA-N 0.000 description 5
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 5
- 235000015165 citric acid Nutrition 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 description 5
- 238000000113 differential scanning calorimetry Methods 0.000 description 5
- 150000002170 ethers Chemical class 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- 125000001153 fluoro group Chemical group F* 0.000 description 5
- 238000006116 polymerization reaction Methods 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- OIQXFRANQVWXJF-QBFSEMIESA-N (2z)-2-benzylidene-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical class CC1(C)C2CCC1(C)C(=O)\C2=C/C1=CC=CC=C1 OIQXFRANQVWXJF-QBFSEMIESA-N 0.000 description 4
- UWNADWZGEHDQAB-UHFFFAOYSA-N 2,5-dimethylhexane Chemical group CC(C)CCC(C)C UWNADWZGEHDQAB-UHFFFAOYSA-N 0.000 description 4
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 4
- CYPRITPRLKLGLB-UHFFFAOYSA-N 3-(3-methoxypropylamino)cyclohex-2-en-1-one Chemical compound COCCCNC1=CC(=O)CCC1 CYPRITPRLKLGLB-UHFFFAOYSA-N 0.000 description 4
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 150000001335 aliphatic alkanes Chemical class 0.000 description 4
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 4
- 229940063655 aluminum stearate Drugs 0.000 description 4
- 229940064734 aminobenzoate Drugs 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000004305 biphenyl Substances 0.000 description 4
- 235000010290 biphenyl Nutrition 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- DENRZWYUOJLTMF-UHFFFAOYSA-N diethyl sulfate Chemical compound CCOS(=O)(=O)OCC DENRZWYUOJLTMF-UHFFFAOYSA-N 0.000 description 4
- 229940008406 diethyl sulfate Drugs 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 4
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 4
- HUVYTMDMDZRHBN-UHFFFAOYSA-N drometrizole trisiloxane Chemical compound C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)CC(C)CC1=CC(C)=CC(N2N=C3C=CC=CC3=N2)=C1O HUVYTMDMDZRHBN-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 210000000720 eyelash Anatomy 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 229960001679 octinoxate Drugs 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 4
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 4
- 229920000058 polyacrylate Polymers 0.000 description 4
- 150000003077 polyols Chemical class 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 239000003380 propellant Substances 0.000 description 4
- 210000004761 scalp Anatomy 0.000 description 4
- 229940057429 sorbitan isostearate Drugs 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- 238000005292 vacuum distillation Methods 0.000 description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 3
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 description 3
- KXTAOXNYQGASTA-UHFFFAOYSA-N 2-benzylidenepropanedioic acid Chemical class OC(=O)C(C(O)=O)=CC1=CC=CC=C1 KXTAOXNYQGASTA-UHFFFAOYSA-N 0.000 description 3
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 description 3
- 229940095095 2-hydroxyethyl acrylate Drugs 0.000 description 3
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 3
- 241001562081 Ikeda Species 0.000 description 3
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 3
- 208000012641 Pigmentation disease Diseases 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 125000005907 alkyl ester group Chemical group 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 229960005193 avobenzone Drugs 0.000 description 3
- 239000002610 basifying agent Substances 0.000 description 3
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 description 3
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
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- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical class OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 229960004624 perflexane Drugs 0.000 description 1
- ZJIJAJXFLBMLCK-UHFFFAOYSA-N perfluorohexane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F ZJIJAJXFLBMLCK-UHFFFAOYSA-N 0.000 description 1
- NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229920001523 phosphate polymer Polymers 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940120149 polyglyceryl-3 ricinoleate Drugs 0.000 description 1
- 229920006389 polyphenyl polymer Chemical group 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- XATKDVHSLQMHSY-RMKNXTFCSA-N propan-2-yl (e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound COC1=CC=C(\C=C\C(=O)OC(C)C)C=C1 XATKDVHSLQMHSY-RMKNXTFCSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 239000010493 quinoa oil Substances 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000004170 rice bran wax Substances 0.000 description 1
- 235000019384 rice bran wax Nutrition 0.000 description 1
- 239000010666 rose oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- NHZIBLPDGIARQC-UHFFFAOYSA-N sodium;4-hydroxy-5-(2-hydroxy-4-methoxybenzoyl)-2-methoxybenzenesulfonic acid Chemical compound [Na+].OC1=CC(OC)=CC=C1C(=O)C1=CC(S(O)(=O)=O)=C(OC)C=C1O NHZIBLPDGIARQC-UHFFFAOYSA-N 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 239000003890 substance P antagonist Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000012749 thinning agent Substances 0.000 description 1
- ODBLHEXUDAPZAU-UHFFFAOYSA-N threo-D-isocitric acid Natural products OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- JLGLQAWTXXGVEM-UHFFFAOYSA-N triethylene glycol monomethyl ether Chemical compound COCCOCCOCCO JLGLQAWTXXGVEM-UHFFFAOYSA-N 0.000 description 1
- OYOGCAUNFUJOMO-UHFFFAOYSA-N trimethyl(octyl)silane Chemical compound CCCCCCCC[Si](C)(C)C OYOGCAUNFUJOMO-UHFFFAOYSA-N 0.000 description 1
- SCRSFLUHMDMRFP-UHFFFAOYSA-N trimethyl-(methyl-octyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C SCRSFLUHMDMRFP-UHFFFAOYSA-N 0.000 description 1
- PGRZLADNCDNGTC-UHFFFAOYSA-N trimethyl-(methyl-propyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C PGRZLADNCDNGTC-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- RSJKGSCJYJTIGS-UHFFFAOYSA-N undecane Chemical compound CCCCCCCCCCC RSJKGSCJYJTIGS-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical class [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Definitions
- Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one citric acid ester
- the present invention relates to a composition, preferably a cosmetic or dermatological composition, comprising at least one merocyanine of formula (1 ) or (2) that will be defined below in detail and at least one oily phase comprising at least one ester of a di- or tricarboxylic acid and of C1-C24 alcohols.
- the present invention also relates to a non-therapeutic cosmetic process for caring for and/or making up a keratin material, comprising the application, to the surface of said keratin material, of at least one composition according to the invention as defined above.
- the invention also relates to a non-therapeutic cosmetic process for limiting the darkening of the skin and/or improving the colour and/or uniformity of the complexion, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.
- the invention also relates to a non-therapeutic cosmetic process for preventing and/or treating the signs of ageing of a keratin material, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.
- UVA rays with wavelengths of between 320 and 400 nm penetrate more deeply into the skin than UVB rays. UVA rays cause immediate and persistent browning of the skin. Daily exposure to UVA rays, even of short duration, under normal conditions can result in damage to the collagen fibres and the elastin, which is reflected by a modification of the microrelief of the skin, the appearance of wrinkles and uneven pigmentation (liver spots, heterogeneity of the complexion).
- UVA and UVB radiation Protection against UVA and UVB radiation is therefore necessary.
- An effective photoprotective product must protect against both UVA and UVB radiation.
- photoprotective compositions have been proposed to date to overcome the effects induced by UVA and/or UVB radiation. They generally contain organic UV-screening agents and/or inorganic UV-screening agents, which function according to their own chemical nature and according to their own properties by absorption, reflection or scattering of the UV radiation. They generally contain mixtures of liposoluble organic screening agents and/or of water-soluble UV-screening agents combined with metal oxide pigments such as titanium dioxide or zinc oxide.
- compositions intended to limit darkening of the skin, and to improve the colour and uniformity of the complexion have been proposed to date. It is well known in the field of antisun products that such compositions can be obtained by using UV-screening agents, and in particular UVB- screening agents. Some compositions may also contain UVA-screening agents. This screening system must cover UVB protection for the purpose of limiting and controlling the neosynthesis of melanin promoting overall pigmentation, but must also cover UVA protection in order to limit and control the oxidation of the already existing melanin resulting in darkening of the skin colour.
- compositions containing a particular combination of UV-screening agents that would be specially suitable for photoprotection of the skin and particularly for an improvement in the quality of the skin both in terms of the colour and in terms of its mechanical elasticity properties.
- this improvement is particularly desired on skin that is already pigmented, for the purpose of not increasing either the pigmentary melanin load or the structure of the melanin already present within the skin.
- the majority of organic UV-screening agents consist of aromatic compounds which absorb in the wavelength range between 280 and 370 nm.
- the desired photoprotective compounds must also have good cosmetic properties, good solubility in the usual solvents and in particular in fatty substances such as oils, and also good photostability alone or in combination with other UV-screening agents. They must also be colourless or at least have a colour that is cosmetically acceptable for consumers.
- compositions in particular a cosmetic or dermatological composition, comprising at least one merocyanine of formula (1 ) or (2) that will be defined below in detail and at least one oily phase comprising at least one ester of C2-C22 di- or tricarboxylic acids and of C1-C24 alcohols.
- esters of C2- C22 di- or tricarboxylic acids and of C1-C24 alcohols it was possible to substantially improve the solubility of these merocyanines in an oily phase, even in the presence of additional organic UV-screening agents.
- the present invention also relates to a non-therapeutic cosmetic process for caring for and/or making up a keratin material, comprising the application, to the surface of said keratin material, of at least one composition according to the invention as defined above.
- the invention also relates to a non-therapeutic cosmetic process for limiting the darkening of the skin and/or improving the colour and/or uniformity of the complexion, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.
- the invention also relates to a non-therapeutic cosmetic process for preventing and/or treating the signs of ageing of a keratin material, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.
- composition according to the invention is intended for topical application and thus contains a physiologically acceptable medium.
- physiologically acceptable medium means here a medium that is compatible with keratin materials.
- the term “keratin material” notably means the skin, the scalp, keratin fibres such as the eyelashes, the eyebrows, head hair, bodily hair, the nails, and mucous membranes such as the lips, and more particularly the skin and the mucous membranes (of the body, face, area around the eyes, eyelids, lips, preferably of the body, face and lips).
- the term "preventing” or “prevention” is intended to mean reducing the risk of occurrence or slowing down the occurrence of a given phenomenon, namely, according to the present invention, the signs of ageing of a keratin material.
- the merocyanine compounds in accordance with the invention correspond to formula (1 ) or (2) below:
- Ri and R2 independently of each other, are hydrogen; a C1-C22 alkyl group, a C2-C22 alkenyl group, or a C2-C22 alkynyl group, these groups possibly being substituted with at least one hydroxyl group or else interrupted with at least one -O-; or else R1 and R2 form, together with the nitrogen atom which links them, a -(CH2)n- ring which may be optionally interrupted with -0- or -NH-;
- Re is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said groups possibly being substituted with one or more OH;
- R4 and R5 are hydrogens; or R4 and R5 form a -(CH2)n- ring which may be substituted with a C1-C4 alkyl group and/or interrupted with one or more -0- or with -NH-; n is a number between 2 and 7;
- R7 and Rs independently of each other, are hydrogen; a C1-C22 alkyl group, a C2- C22 alkenyl group, a C2-C22 alkynyl group, said groups possibly being interrupted with one or more 0 and/or substituted with one or more OH; a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said groups possibly being interrupted with one or more -O-; or else R7 and Rs form, together with the nitrogen which links them, a -(CH2)n- ring which may be interrupted with one or more -O-;
- R9 and R10 are hydrogen; or R9 and R10 form a -(CH2)n- ring potentially substituted with a C1-C4 alkyl and/or interrupted with an -0- or -NH-;
- A is -O-; or -NH;
- R11 is a C1-C22 alkyl group; a C2-C22 alkenyl group; a C2-C22 alkynyl group; a C3- C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said groups possibly being interrupted with one or more O; or a C1-C22 alkyl group or a C2-C22 alkenyl group which is substituted with a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said C3-C22 cycloalkyl group or C3-C22 cycloalkenyl group possibly being interrupted with one or more -O-.
- the compounds of formula (1 ) or (2) have the following characteristics:
- R1 denotes a hydroxyethyl
- R2 does not denote a hydrogen, a methyl or an ethyl or a hydroxyethyl
- R1 denotes hydrogen
- R2 is not 1- hydroxy-3-methylbut-2-yl
- Re is substituted with one or more OH, one from among R1 and R2 is a C4-C22 alkyl group; or else R1 and R2 form, together with the nitrogen to which they are bonded, a piperidyl or morpholinyl radical;
- the preferred compounds are those of formula (1 ) or (2) in which:
- R1 and R2 independently of each other, are hydrogen; a C4-C12 alkyl group; or a C3-C12 hydroxyalkyl group; or at least one of R1 or R2 is a C3-C12 hydroxyalkyl; and
- R3, R4 and R5 have the same meanings indicated previously.
- the preferred compounds are also those of formula (1 ) in which: Re is a C1-C12 alkyl group, which may be potentially substituted with one or more hydroxyls.
- Re is a C1-C12 alkyl group, which may be substituted with one or more hydroxyls; one of the radicals R1 or R2 is a C4-C22 alkyl group; or else R1 and R2 form, together with the nitrogen which links them, a -(CH2)n- ring which may be interrupted with - 0- and/or -NH-; and
- R4 and R5 and n have the same meanings indicated previously.
- R11 is a -(CH2)m-O-R-i2 radical, in which
- R12 is a C1-C12 alkyl group; or a C-i-Ce alkoxy-C-i-Ce alkyl group; m is a number from 1 to 5; and
- R7, Rs, R9, R10 and A have the same meanings indicated previously.
- R1 and R2 on the one hand, and R7 and Rs, on the other hand, respectively form, together with the nitrogen atom to which they are respectively bonded, a piperidyl radical or a morpholinyl radical.
- the preferred compounds are also those of formula (1 ) and (2) in which:
- R4 and R5 and R9 and R10 respectively form a carbon-based ring which contains 6 carbon atoms.
- R1 and R2 independently of each other, are a hydrogen; or a C1-C22 alkyl group; or a C1-C22 hydroxyalkyl group; or R1 and R2 form, together with the nitrogen to which they are bonded, a piperidyl or morpholinyl radical;
- Re is a C1-C22 alkyl group, which may be substituted with one or more -OH; R4 and R5 are a hydrogen; or R4 and R5 are linked together to form a carbon-based ring which contains 6 carbon atoms.
- R1 and R2 independently of each other, are a hydrogen; or a C1-C22 hydroxyalkyl group; in which at least one of the radicals R1 and R2 is a C1-C22 hydroxyalkyl group;
- Re is a C1-C22 alkyl group
- R4 and R5 are hydrogens; or R4 and R5 are bonded together to form a carbonbased ring which contains 6 carbon atoms.
- R7 and Rs independently of each other, are a hydrogen or a C-i-Ce alkyl group, which may be interrupted with one or more -O-;
- A is -0- or -NH
- R11 is a C1-C22 alkyl
- R9 and R10 are a hydrogen; or R9 and R10 are bonded together to form a carbonbased ring which contains 6 carbon atoms.
- R7 and Re form, together with the nitrogen atom to which they are bonded, a morpholinyl or piperidyl radical;
- A is -O- or -NH
- R11 is a C1-C22 alkyl group, which may be interrupted with one or more -O-;
- R9 and R10 are hydrogens; or R9 and R10 are bonded together to form a carbonbased ring which contains 6 carbon atoms.
- R11 is a -(CH2)m-O-Ri2 radical, in which R12 is a C1-C4 alkyl group; or a C1-C4 alkoxy-Ci-C4 alkyl group; m is a number from 1 to 3; and
- R7 and Rs independently of each other, are a hydrogen; a C1-C12 alkyl group, which may be interrupted with one or more O; or R7 and Rs form, together with the nitrogen atom to which they are bonded, a morpholinyl or piperidyl radical;
- R9 and R10 are hydrogens or together form a carbon-based ring which contains 6 carbon atoms
- A is -O- or -NH.
- the merocyanine compounds of the invention may be for example in the E/E, E/Z or Z/Z geometric isomer form.
- alkyl, cycloalkyl, alkenyl, alkylidene or cycloalkenyl chains may be linear or branched, monocyclic or polycyclic chains.
- a C1-C22 alkyl group is, for example, a methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, 2-pentyl, 3-pentyl, 2,2- dimethylpropyl, n-hexyl, n-octyl, 1 ,1 ,3,3-tetramethylbutyl, 2-ethylhexyl, nonyl, decyl, n-octadecyl, eicosyl or dodecyl.
- a substituted alkyl group is, for example, a methoxyethyl, ethoxypropyl, 2-ethylhexyl, hydroxyethyl, chloropropyl, N,N-diethylaminopropyl, cyanoethyl, phenethyl, benzyl, p-tert-butylphenethyl, p-tert-octylphenoxyethyl, 3-[2,4- bis(tert-amyl)phenoxy]propyl, ethoxycarbonylmethyl-2-(2- hydroxyethoxy)ethyl or 2-fury lethy I .
- a hydroxy-substituted alkyl group is, for example, a hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, hydroxypentyl, hydroxyhexyl, hydroxyheptyl, hydroxyoctyl, hydroxynonyl or hydroxydecyl.
- a C2-C22 alkenyl group is, for example, a linear C2-C12 alkenyl chain or preferentially a branched C3-C12 alkenyl chain.
- a C2-C22 alkenyl is, for example, a vinyl, allyl, 2-propen-2-yl, 2-buten-1-yl, 3-buten-1-yl, 1 ,3-butadien-2-yl, 2- cyclobuten-1 -yl, 2-penten-1-yl, 3-penten-2-yl, 2-methyl-1-buten-3-yl, 2- methyl-3-buten-2-yl, 3-methyl-2-buten-1-yl, 1 ,4-pentadien-3-yl, 2- cyclopenten-1 -yl, 2-cyclohexen-1-yl, 3-cyclohexen-1 -yl, 2,4-cyclohexadien-1- yl, 1 -p-menthen-8-yl, 4(10)-thu
- a C3-C12 cycloalkyl group is, for example, a cyclopropyl, cyclobutyl, cyclopentyl, trimethylcyclohexyl or, preferentially, a cyclohexyl.
- Examples of merocyanines according to the present invention are listed in Table 1 :
- A is -0- or -NH
- R is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said groups possibly being interrupted with one or more 0.
- the merocyanine compounds of the invention may be in the E/E- or E/Z geometric isomer forms thereof:
- A is -O-;
- R is a C1-C22 alkyl, which may be interrupted with one or more 0.
- the E/Z form has the following structure:
- the E/E form has the following structure:
- the screening merocyanines in accordance with the invention may be present in the compositions according to the invention in a concentration ranging from 0.1 % to 15% by weight, and preferentially from 0.2% to 10% by weight and even better still from 0.5% to 5% by weight relative to the total weight of the composition.
- the compounds of formulae (1 ) and (2) and especially of formula (3) may be prepared according to known processes, as described, for example, in J. Org. Chem. USSR (English Translation) 26(8), page 1562f (1990); J. Heterocycl. Chem. 33(3), pages 763-766 (1996); Khimiya Geterotsiklicheskikh Soedinenii 11 , pages 1537-1543 (1984); Khimiya Geterotsiklicheskikh Soedinenii 3, pages 397-404 (1982); Chem. Heterocycl. Comp. (English Translation) 24(8), 914-919 (1988) and in Synthetic Communications Vol. 33, No. 3, 2003, pages 367-371.
- the compounds of formula (1 ) or (2) in which R4 and R5, on the one hand, or R9 and R10, on the other hand, together form a carbocyclic ring containing 6 carbon atoms, respectively, may be prepared according to the protocols described in patent application WO 2007/071582, in IP.com Journal (2009), 9(5A), 29-30 IPCOM000182396D under the title “Process for producing 3- amino-2-cyclohexan-1-ylidene compounds” and in US-A-4,749,643 on col. 13, line 66 - col. 14, line 57 and the references cited in this regard.
- the compounds of formula (3) such as compound 2-ethoxyethyl (2Z)-cyano ⁇ 3-[(3-methoxypropyl)amino]cyclohex-2-en-1 - ylidenejethanoate (25) can be synthesized according to the synthesis scheme described in the publication by B. Winkler et al., Tetrahedron Letters, 55 (2014) 1749-1751 , which is intitled « A cyclic merocyanine UV- A absorber : mechanism of formation and crystal structure » and shown below, for the compounds of formula (3) : [formula 8 bis]
- composition in accordance with the invention comprises at least one ester of C2-C22 di- or tricarboxylic acid and of C1-C24 alcohols.
- the C2-C22 di- or tricarboxylic acids are in particular chosen from citric acid, malic acid, malonic acid, succinic acid, adipic acid, maleic acid, fumaric acid, tartaric acid, isocitric acid, and mixtures thereof.
- the acids are preferably citric acid and adipic acid, and even more preferentially the acid is citric acid.
- the C1-C24 alcohols are not oxyalkylenated. They may be aliphatic, cyclic or aromatic, having from 1 to 24 carbon atoms. They are in particular chosen from phenol, benzyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, methanol, ethanol, propanol, n-butanol, t-butanol, pentanol and hexanol.
- the alcohol(s) is/are C-i-Ce alcohol(s) and can be chosen from methanol, ethanol, propanol, n-butanol, t-butanol, pentanol, hexanol, and even more preferentially the alcohol is ethanol.
- ester(s) of C2-C22 di- or tricarboxylic acid and of C1-C24 alcohols can be mono- or polyesterified.
- Monoesterified is understood to mean that only one of the two or three carboxylic acid functions is esterified.
- Polyesterified is understood to mean that at least two carboxylic acid functions are esterified.
- the di- or tricarboxylic acid can be esterified with a number of different alcohols. It is preferably esterified with just one alcohol.
- the composition comprises at least one ester of C3-C22 tricarboxylic acid and of C1-C24, preferably C-i-Ce, alcohols. This/these ester(s) can be mono-, di- or triesterified.
- Monoesterified is understood to mean that only one of the three carboxylic acid functions is esterified. Diesterified is understood to mean that two of the three carboxylic acid functions are esterified. Triesterified is understood to mean that all three carboxylic acid functions are esterified.
- ester(s) of C3- C22 tricarboxylic acid and of C-i-Ce alcohols are triesterified.
- ester(s) of C3- C22 tricarboxylic acid and of C-i-Ce alcohols are chosen from the compounds of formula (9) below:
- R1, R2 and R3 represent, independently of each other, a hydrogen atom or a monovalent, saturated or unsaturated, aliphatic, cyclic or aromatic hydrocarbon- based group having from 1 to 6 carbon atoms;
- R represents a hydrogen atom or a hydroxyl radical.
- R1, R2 and R3 represent, independently of each other, a hydrogen atom or a linear or branched, substituted or unsubstituted, preferably unsubstituted, C-i-Ce alkyl radical, and in particular a radical chosen from methyl, ethyl, propyl, n-butyl, t-butyl, pentyl and hexyl radicals.
- R1, R2 and R3 are chosen, independently of each other, from a hydrogen atom and methyl, ethyl, propyl, n-butyl and t-butyl radicals.
- the radicals R1, R2 and R3 are identical and are chosen from C-i-Ce, preferably C1-C4, alkyl radicals and even more preferentially are ethyl radicals.
- R represents a hydroxyl radical.
- the ester of tricarboxylic acid and of C-i-Ce alcohols has the following formula:
- esters of di- or tricarboxylic acid and of C1 -C24 alcohols as defined above are generally present in the composition according to the invention in concentrations ranging from 0.1 % to 98% by weight, more particularly from 0.5% to 50% by weight, preferably from 1 % to 20% by weight, and even more preferentially from 1 % to 15% by weight, better still from 1 % to 10% by weight, relative to the total weight of the composition.
- the composition according to the invention comprises : a) at least one merocyanine corresponding to formula (3) below, and also the geometric isomer forms, notably the E/E- or E/Z-geometric isomer forms, thereof:
- A is -O- or -NH;
- R is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said groups possibly being interrupted with one or more 0 ; and b) at least one ester of tricarboxylic acid and of C-i-Ce alcohols having the following formula:
- R1, R2 and R3 represent, independently of each other, a hydrogen atom or a monovalent, saturated or unsaturated, aliphatic, cyclic or aromatic hydrocarbon- based group having from 1 to 6 carbon atoms;
- R represents a hydrogen atom or a hydroxyl radical.
- the composition according to the invention comprises : a) at least one merocyanine corresponding to formula (3) below, and also the geometric isomer forms, notably the E/E- or E/Z-geometric isomer forms, thereof:
- A is -0- or -NH
- R is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said groups possibly being interrupted with one or more 0 ; and b) the ester of tricarboxylic acid and of C-i-Ce alcohols has the following formula: [Formula 10]
- the composition comprises at least one polymer comprising monomer units of formulae (A) and (B) defined below:
- R1 is chosen from alkyl or alkylene radicals, and at least 60% by weight of the Ri groups are radicals chosen from stearyl and behenyl radicals, the percentage by weight relating to the sum of all the Ri groups present in the polymer, and the weight ratio of the sum of all the hydroxyethyl acrylate units to the sum of all the acrylate units bearing the Ri group ranges from 1 :30 to 1 :1 , and the sum of the total of units A and B is at least 95% by weight relative to the total weight of the polymer.
- Ri is constituted of alkyl radicals, preferably of C16-C22 alkyl radicals, and more preferentially of stearyl (Cis) radicals or of behenyl (C22) radicals.
- At least 70% by weight of the groups R1 are stearyl or behenyl radicals, preferentially at least 80% by weight and more preferentially at least 90% by weight.
- all the R1 groups are behenyl radicals.
- all the R1 groups are stearyl radicals.
- said weight ratio ranges from 1 :15 to 1 :1 and preferentially ranges from 1 :10 to 1 :4.
- the polymer units present in the polymer consist of the units (A) and (B) previously described.
- the polymer has a number-average molecular weight Mn ranging from 2000 to 9000 g/mol, preferably ranging from 5000 to 9000 g/mol.
- the numberaverage molecular weight may be measured via the gel permeation chromatography method, for example according to the method described in the example hereinbelow.
- the polymer has a melting point ranging from 40°C to 70°C and preferentially ranging from 45°C to 67°C.
- the melting point is measured by differential scanning calorimetry (DSC), for example according to the method described in the example hereinbelow.
- the polymer when the polymer is such that at least 60% by weight of the groups R1 are stearyl radicals, then the polymer preferably has a melting point ranging from 40 to 60°C, and preferentially ranging from 45 to 55°C.
- the polymer when the polymer is such that at least 60% by weight of the groups R1 are behenyl radicals, then the polymer has a melting point ranging from 60°C to 70°C, and preferentially ranging from 63°C to 67°C.
- the polymerization may be performed according to known methods, such as solution polymerization or emulsion polymerization.
- the polymerization is, for example, described in document US 2007/0264204.
- the acrylic polymer(s) as defined previously can be present in the composition according to the invention in a content of active material ranging from 0.05% to 10% by weight, relative to the total weight of the composition, preferably ranging from 0.1 % to 5% by weight and better still ranging from 0.2% to 3% by weight.
- composition in accordance with the invention comprises at least one oily phase.
- oil phase means a phase comprising at least one oil and all of the liposoluble and lipophilic ingredients and the fatty substances used for the formulation of the compositions of the invention.
- oil is intended to mean any fatty substance that is in liquid form at ambient temperature (20-25°C) and atmospheric pressure (760 mmHg).
- the oily phase may comprise, in addition to the merocyanine screening agent(s) and optionally the lipophilic additional screening agents and the ester(s) of di- or tricarboxylic acid according to the invention, at least one volatile or non-volatile hydrocarbon-based oil and/or one volatile and/or nonvolatile silicone oil and/or one volatile and/or non-volatile fluoro oil.
- silicon oil is understood to mean an oil comprising at least one silicon atom, and in particular at least one Si-0 group.
- hydrocarbon-based oil is intended to mean an oil mainly containing hydrogen and carbon atoms and optionally one or more heteroatoms, in particular nitrogen and oxygen.
- these oils may in particular contain one or more carboxy, ester, ether, hydroxyl functions.
- fluoro oil is intended to mean an oil comprising at least one fluorine atom.
- volatile oil is intended to mean an oil that is capable of evaporating on contact with the skin or the keratin fibre in less than one hour, at ambient temperature and atmospheric pressure.
- volatile oil(s) of the invention are volatile cosmetic oils, which are liquid at ambient temperature, having a non-zero vapour pressure, at ambient temperature and atmospheric pressure, ranging in particular from 0.13 Pa to 40 000 Pa (10 -3 to 300 mmHg), in particular ranging from 1.3 Pa to 13 000 Pa (0.01 to 100 mmHg) and more particularly ranging from 1.3 Pa to 1300 Pa (0.01 to 10 mmHg).
- non-volatile oil is understood to mean an oil which remains on the skin or the keratin fibre, at ambient temperature and atmospheric pressure, for at least several hours and which has in particular a vapour pressure of less than 10’ 3 mmHg (0.13 Pa).
- non-volatile hydrocarbon-based oils that may be used according to the invention, mention may notably be made of:
- hydrocarbon-based oils of plant origin such as glyceride triesters, which are generally triesters of fatty acids and of glycerol, the fatty acids of which can have varied chain lengths from C4 to C24, it being possible for these chains to be saturated or unsaturated and linear or branched; these oils are in particular wheatgerm oil, sunflower oil, grape seed oil, sesame oil, corn oil, apricot oil, castor oil, shea oil, avocado oil, olive oil, soybean oil, sweet almond oil, palm oil, rapeseed oil, cottonseed oil, hazelnut oil, macadamia oil, jojoba oil, alfalfa oil, poppy oil, pumpkin oil, marrow oil, blackcurrant oil, evening primrose oil, millet oil, barley oil, quinoa oil, rye oil, safflower oil, candlenut oil, passionflower oil and musk rose oil; or else caprylic/capric acid triglycerides, such as those sold by
- synthetic esters such as the oils of formula RCOOR' in which R represents a linear or branched fatty acid residue comprising from 1 to 40 carbon atoms and R' represents a hydrocarbon-based chain that is especially branched, containing from 1 to 40 carbon atoms, with the proviso that R + R' > 10, for instance Purcellin oil (cetostearyl octanoate), isopropyl myristate, isopropyl palmitate, C12-C15 alkyl benzoate, such as the product sold under the trade name Finsolv TN® or Witconol TN® by the company Witco orTegosoft TN® by the company Evonik Goldschmidt, 2-ethylphenyl benzoate, such as the commercial product sold under the name X- Tend 226® by the company ISP, isopropyl lanolate, hexyl laurate, diisopropyl adipate, isononyl isononan
- fatty alcohols that are liquid at ambient temperature, containing a branched and/or unsaturated carbon-based chain containing from 12 to 26 carbon atoms, for instance octyldodecanol, isostearyl alcohol, oleyl alcohol, 2-hexyldecanol, 2- butyloctanol or 2-undecylpentadecanol;
- C12-C22 higher fatty acids such as oleic acid, linoleic acid or linolenic acid
- carbonates such as dicaprylyl carbonate, such as the product sold under the name Cetiol CC® by the company Cognis; and mixtures thereof.
- non-volatile hydrocarbon-based oils that may be used according to the invention, preference will be given more particularly to glyceride triesters and in particular to caprylic/capric acid triglycerides, synthetic esters and in particular diisopropyl adipate, diisopropyl sebacate, isopropyl palmitate, dicaprylyl carbonate, isononyl isononanoate, oleyl erucate, C12-C15 alkyl benzoate, 2-ethylphenyl benzoate and fatty alcohols, in particular octyldodecanol.
- the non-volatile hydrocarbon-based oils are chosen from diisopropyl adipate, diisopropyl sebacate, isopropyl palmitate and dicaprylyl carbonate.
- hydrocarbon-based oils that may be used according to the invention, mention may be made in particular of hydrocarbon-based oils containing from 8 to 16 carbon atoms and in particular of branched Cs-C alkanes, such as Cs-C isoalkanes of petroleum origin (also known as isoparaffins), such as isododecane (also known as 2, 2, 4,4,6- pentamethylheptane), isodecane or isohexadecane, the oils sold under the Isopar or Permethyl trade names, branched Cs-C esters, isohexyl neopentanoate, and mixtures thereof.
- Cs-C isoalkanes of petroleum origin also known as isoparaffins
- isododecane also known as 2, 2, 4,4,6- pentamethylheptane
- isodecane or isohexadecane the oils sold under the Isopar or Permethyl trade names
- volatile hydrocarbon-based oils for instance petroleum distillates, in particular those sold under the name Shell Solt® by the company Shell, may also be used.
- the volatile solvent is chosen from volatile hydrocarbon-based oils containing from 8 to 16 carbon atoms, and mixtures thereof.
- the non-volatile silicone oils may be notably chosen from non-volatile polydimethylsiloxanes (PDMSs), polydimethylsiloxanes including alkyl or alkoxy groups which are pendent and/or at the end of the silicone chain, these groups each containing from 2 to 24 carbon atoms, or phenyl silicones, such as phenyl trimethicones, phenyl dimethicones, phenyltrimethylsiloxydiphenylsiloxanes, diphenyl dimethicones, diphenylmethyldiphenyltrisiloxanes or 2-phenylethyl trimethylsiloxysilicates.
- PDMSs non-volatile polydimethylsiloxanes
- phenyl silicones such as phenyl trimethicones, phenyl dimethicones, phenyltrimethylsiloxydiphenylsiloxanes, diphenyl dimethicones, diphen
- volatile silicone oils examples include volatile linear or cyclic silicone oils, in particular those with a viscosity ⁇ 8 centistokes (8x1 O’ 6 m 2 /s) and especially containing from 2 to 7 silicon atoms, these silicones optionally comprising alkyl or alkoxy groups containing from 1 to 10 carbon atoms.
- volatile silicone oils that may be used in the invention, mention may notably be made of octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, heptamethyloctyltrisiloxane, hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane and dodecamethylpentasiloxane, and mixtures thereof.
- R represents an alkyl group containing from 2 to 4 carbon atoms and of which one or more hydrogen atoms may be substituted with a fluorine or chlorine atom.
- oils of general formula (11 ) mention may be made of:
- Use may also be made of volatile fluoro oils, such as nonafluoromethoxybutane, decafluoropentane, tetradecafluorohexane, dodecafluoropentane, and mixtures thereof.
- volatile fluoro oils such as nonafluoromethoxybutane, decafluoropentane, tetradecafluorohexane, dodecafluoropentane, and mixtures thereof.
- An oily phase according to the invention may also comprise other fatty substances, mixed with or dissolved in the oil.
- Another fatty substance that may be present in the oily phase may be, for example:
- waxes such as lanolin, beeswax, carnauba or candelilla wax, rice bran wax, paraffin waxes, lignite waxes, microcrystalline waxes, ceresin or ozokerite, or synthetic waxes, such as polyethylene waxes or Fischer-Tropsch waxes;
- a pasty compound such as polymeric or non-polymeric silicone compounds, esters of a glycerol oligomer, arachidyl propionate, fatty acid triglycerides and derivatives thereof;
- the overall oily phase including all the lipophilic substances of the composition capable of being dissolved in this same phase, represents from 5% to 95% by weight and preferentially from 10% to 80% by weight, relative to the total weight of the composition.
- composition in accordance with the invention may additionally comprise at least one aqueous phase.
- the aqueous phase contains water and optionally other water-soluble or water-miscible organic solvents.
- An aqueous phase that is suitable for use in the invention may comprise, for example, a water chosen from a natural spring water, such as water from La Roche-Posay, water from Vittel, water from Saint Gervais Mont Blanc or waters from Vichy, or a floral water.
- a natural spring water such as water from La Roche-Posay, water from Vittel, water from Saint Gervais Mont Blanc or waters from Vichy, or a floral water.
- the water-soluble or water-miscible solvents that are suitable for use in the invention comprise short-chain monoalcohols, for example C1-C4 monoalcohols, such as ethanol or isopropanol; diols or polyols, such as ethylene glycol, 1 ,2-propylene glycol, 1 ,3-butylene glycol, hexylene glycol, diethylene glycol, dipropylene glycol, 2-ethoxyethanol, diethylene glycol monomethyl ether, triethylene glycol monomethyl ether, glycerol and sorbitol, and mixtures thereof.
- C1-C4 monoalcohols such as ethanol or isopropanol
- diols or polyols such as ethylene glycol, 1 ,2-propylene glycol, 1 ,3-butylene glycol, hexylene glycol, diethylene glycol, dipropylene glycol, 2-ethoxyethanol, diethylene glycol monomethyl ether, triethylene
- use may more particularly be made of ethanol, propylene glycol, glycerol, and mixtures thereof.
- the overall aqueous phase including all the hydrophilic substances of the composition capable of being dissolved in this same phase, represents from 5% to 95% by weight and preferentially from 10% to 80% by weight, relative to the total weight of the composition.
- compositions according to the invention may also contain one or more additional UV-screening agents chosen from hydrophilic, lipophilic or insoluble organic UV-screening agents and/or one or more mineral pigments. It will preferentially be constituted of at least one hydrophilic, lipophilic or insoluble organic UV-screening agent.
- hydrophilic UV-screening agent is intended to mean any cosmetic or dermatological organic or inorganic compound for screening out UV radiation, which can be fully dissolved in molecular form in a liquid aqueous phase or else which can be dissolved in colloidal form (for example in micellar form) in a liquid aqueous phase.
- lipophilic screening agent is intended to mean any cosmetic or dermatological organic or inorganic compound for screening out UV radiation, which can be fully dissolved in molecular form in a liquid fatty phase or else which can be dissolved in colloidal form (for example in micellar form) in a liquid fatty phase.
- insoluble UV-screening agent is intended to mean any cosmetic or dermatological organic or inorganic compound for screening out UV radiation which has a solubility in water of less than 0.5% by weight and a solubility of less than 0.5% by weight in the majority of organic solvents such as liquid paraffin, fatty alcohol benzoates and fatty acid triglycerides, for example Miglyol 812® sold by the company Dynamit Nobel.
- This solubility determined at 70°C, is defined as the amount of product in solution in the solvent at equilibrium with an excess of solid in suspension after returning to ambient temperature. It may be readily evaluated in the laboratory.
- the additional organic UV-screening agents are chosen in particular from cinnamic compounds; anthranilate compounds; salicylic compounds; dibenzoylmethane compounds; benzylidenecamphor compounds; benzophenone compounds; (3, [3-diphenylacrylate compounds; triazine compounds; benzotriazole compounds; benzalmalonate compounds, in particular those cited in patent US 5 624 663; benzimidazole derivatives; imidazoline compounds; bis-benzazolyl compounds, as described in patents EP 669 323 and US 2 463 264; p-aminobenzoic (PABA) compounds; methylenebis(hydroxyphenylbenzotriazole) compounds, as described in patent applications US 5 237 071 , US 5 166 355, GB 2 303 549, DE 197 26 184 and EP 893 119; benzoxazole compounds, as described in patent applications EP 0 832 642, EP 1 027 883, EP 1 300 137 and DE 101
- organic photoprotective agents mention may be made of those denoted hereinbelow under their INCI name.
- Cinnamic compounds are Cinnamic compounds:
- Ethylhexyl methoxycinnamate sold in particular under the trade name Parsol MCX® by DSM Nutritional Products,
- Neo Heliopan E 1000® Isoamyl p-Methoxycinnamate, sold under the trade name Neo Heliopan E 1000® by Symrise,
- Butyl Methoxydibenzoylmethane sold in particular under the trade name Parsol 1789® by DSM Nutritional Products,
- Ethylhexyl Dimethyl PABA sold in particular under the name Escalol 507® by ISP,
- PEG-25 PABA sold under the name llvinul P 25® by BASF.
- Ethylhexyl Salicylate sold under the name Neo Heliopan OS® by Symrise
- Dipropylene Glycol Salicylate sold under the name Dipsal® by Scher
- TEA Salicylate sold under the name Neo Heliopan TS® by Symrise.
- Diphenyl acrylate compounds :
- Octocrylene sold in particular under the trade name llvinul N 539® by BASF
- Etocrylene sold in particular under the trade name llvinul N 35® by BASF.
- Benzophenone-1 sold under the trade name Uvinul 400® by BASF,
- Benzophenone-2 sold under the trade name Uvinul D 50® by BASF,
- Benzophenone-3 or Oxybenzone sold under the trade name Uvinul M 40® by BASF,
- Benzophenone-4 sold under the trade name Uvinul MS 40® by BASF,
- Benzophenone-6 sold under the trade name Helisorb 11® by Norquay,
- Benzophenone-8 sold under the trade name Spectra-Sorb UV-24® by American Cyanamid,
- Benzophenone-9 sold under the trade name Uvinul DS 49® by BASF,
- Benzophenone-12, n-Hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate sold under the trade name Uvinul A Plus® or, as a mixture with octyl methoxycinnamate, under the trade name Uvinul A Plus B® by the company BASF,
- Camphor Benzalkonium Methosulfate manufactured under the name Mexoryl SO® by Chimex,
- Phenylbenzimidazole Sulfonic Acid sold in particular under the trade name Eusolex 232® by Merck.
- Neo Heliopan AP® Disodium Phenyl Dibenzimidazole Tetrasulfonate sold under the trade name Neo Heliopan AP® by Haarmann and Reimer.
- Methylene bis-Benzotriazolyl Tetramethylbutylphenol in particular in solid form, such as the product sold under the trade name Mixxim BB/100® by Fairmount Chemical, or in the form of an aqueous dispersion of micronized particles with a mean particle size ranging from 0.01 to 5 pm, more preferentially from 0.01 to 2 pm and more particularly from 0.020 to 2 pm, with at least one alkylpolyglycoside surfactant having the structure C n H2n+iO(C6Hio05)xH, in which n is an integer from 8 to 16 and x is the mean degree of polymerization of the (CeH Os) unit and ranges from 1 .4 to 1 .6, as described in patent GB-A-2 303 549, sold in particular under the trade name Tinosorb M® by BASF, or in the form of an aqueous dispersion of micronized particles with a mean particle size ranging from 0.02 to 2 pm, more preferentially from 0.01 to 1.5
- Neo Heliopan MA® Menthyl anthranilate, sold under the trade name Neo Heliopan MA® by Symrise.
- Polyorganosiloxane comprising benzalmalonate functions such as Polysilicone-15, sold under the trade name Parsol SLX® by Hoffmann-La Roche.
- the preferential organic screening agents are chosen from:
- the particularly preferred organic screening agents are chosen from:
- Drometrizole Trisiloxane and mixtures thereof.
- the inorganic UV-screening agents used in accordance with the present invention are metal oxide pigments. More preferentially, the inorganic UV- screening agents of the invention are metal oxide particles with a mean elementary particle size of less than or equal to 0.5 pm, more preferentially between 0.005 and 0.5 pm, even more preferentially between 0.01 and 0.2 pm, better still between 0.01 and 0.1 pm and more particularly between 0.015 and 0.05 pm.
- They may be chosen in particular from titanium oxide, zinc oxide, iron oxide, zirconium oxide and cerium oxide, or mixtures thereof.
- Such coated or uncoated metal oxide pigments are described in particular in patent application EP-A-0 518 773.
- Commercial pigments that may be mentioned include the products sold by the companies Sachtleben Pigments, Tayca, Merck and Degussa.
- the metal oxide pigments may be coated or uncoated.
- the coated pigments are pigments that have undergone one or more surface treatments of chemical, electronic, mechanochemical and/or mechanical nature with compounds such as amino acids, beeswax, fatty acids, fatty alcohols, anionic surfactants, lecithins, sodium, potassium, zinc, iron or aluminium salts of fatty acids, metal alkoxides (of titanium or aluminium), polyethylene, silicones, proteins (collagen, elastin), alkanolamines, silicon oxides, metal oxides or sodium hexametaphosphate.
- compounds such as amino acids, beeswax, fatty acids, fatty alcohols, anionic surfactants, lecithins, sodium, potassium, zinc, iron or aluminium salts of fatty acids, metal alkoxides (of titanium or aluminium), polyethylene, silicones, proteins (collagen, elastin), alkanolamines, silicon oxides, metal oxides or sodium hexametaphosphate.
- coated pigments are more particularly titanium oxides that have been coated:
- silica such as the product Sunveil® from the company Ikeda
- alumina and aluminum stearate such as the products Microtitanium Dioxide MT 100 T®, MT 100 TX®, MT 100 Z® and MT-01® from the company Tayca, the products Solaveil CT-10 W® and Solaveil CT 100® from the company Uniqema and the product Eusolex T-AVO® from the company Merck,
- iron oxide and iron stearate such as the product Microtitanium Dioxide MT 100 F® from the company Tayca,
- a silicone such as the products Microtitanium Dioxide MT 600 SAS®, Microtitanium Dioxide MT 500 SAS® or Microtitanium Dioxide MT 100 SAS® from the company Tayca, - with silica, alumina and aluminum stearate and treated with a silicone, such as the product STT-30-DS® from the company Titan Kogyo,
- TiO2 pigments doped with at least one transition metal such as iron, zinc or manganese and more particularly manganese.
- said doped pigments are in the form of an oily dispersion.
- the oil present in the oily dispersion is preferably chosen from triglycerides including those of capric/caprylic acids.
- the oily dispersion of titanium oxide particles may also comprise one or more dispersants, for instance a sorbitan ester, for instance sorbitan isostearate, or a polyoxyalkylenated fatty acid ester of glycerol, for instance TRI-PPG-3 myristyl ether citrate and polyglyceryl-3 polyricinoleate.
- the oily dispersion of titanium oxide particles includes at least one dispersant chosen from polyoxyalkylenated fatty acid esters of glycerol. Mention may be made more particularly of the oily dispersion of TiO2 particles doped with manganese in capric/caprylic acid triglyceride in the presence of TRI-PPG-3 myristyl ether citrate and polyglyceryl-3 polyricinoleate and sorbitan isostearate having the INCI name: titanium dioxide (and) TRI-PPG-3 myristyl ether citrate (and) polyglyceryl-3 ricinoleate (and) sorbitan isostearate, for instance the product sold under the trade name Optisol TD50® by the company Croda.
- the uncoated titanium oxide pigments are sold, for example, by the company Tayca under the trade names Microtitanium Dioxide MT 500 B or Microtitanium Dioxide MT 600 B®, by the company Degussa under the name P 25, by the company Wackher under the name Transparent titanium oxide PW®, by the company Miyoshi Kasei under the name LIFTR®, by the company Tomen under the name ITS® and by the company Tioxide under the name Tioveil AQ®
- the uncoated zinc oxide pigments are, for example:
- Nanox® those sold under the name Nanox® by the company Elementis;
- Nanogard WCD 2025® those sold under the name Nanogard WCD 2025® by the company Nanophase Technologies.
- coated zinc oxide pigments are for example:
- Daitopersion Zn-30® and Daitopersion Zn-50® sold under the name Daitopersion Zn-30® and Daitopersion Zn-50® by the company Daito (dispersions in cyclopolymethylsiloxane/oxyethylenated polydimethylsiloxane, containing 30% or 50% of zinc oxides coated with silica and polymethylhydrosiloxane);
- Nanox Gel TN® those sold under the name Nanox Gel TN® by the company Elementis (ZnO dispersed at 55% in C12-C15 alkyl benzoate with hydroxystearic acid polycondensate).
- the uncoated cerium oxide pigments may be, for example, those sold under the name Colloidal Cerium Oxide® by the company Rhone-Poulenc.
- the uncoated iron oxide pigments are sold, for example, by the company Arnaud under the names Nanogard WCD 2002® (FE 45B®), Nanogard Iron FE 45 BL AQ, Nanogard FE 45R AQ® and Nanogard WCD 2006® (FE 45R®) or by the company Mitsubishi under the name TY-220®.
- the coated iron oxide pigments are sold, for example, by the company Arnaud under the names Nanogard WCD 2008 (FE 45B FN)®, Nanogard WCD 2009® (FE 45B 556®), Nanogard FE 45 BL 345® and Nanogard FE 45 BL® or by the company BASF under the name Transparent Iron Oxide®.
- metal oxides especially of titanium dioxide and of cerium dioxide, including the equal-weight mixture of titanium dioxide and cerium dioxide coated with silica, sold by the company Ikeda under the name Sunveil A®, and also the mixture of titanium dioxide and zinc dioxide coated with alumina, silica and silicone, such as the product M 261® sold by the company Sachtleben Pigments, or coated with alumina, silica and glycerol, such as the product M 211® sold by the company Sacht
- coated or uncoated titanium oxide pigments are particularly preferred.
- the additional UV-screening agents according to the invention can be present in the composition according to the invention in a content ranging from 0.1 % to 60% by weight and in particular from 5% to 30% by weight relative to the total weight of the composition.
- composition in accordance with the present invention may also comprise conventional cosmetic adjuvants chosen in particular from organic solvents, ionic or non-ionic thickeners, softeners, humectants, opacifiers, stabilizers, emollients, silicones, antifoams, fragrances, preservatives, anionic, cationic, non-ionic, zwitterionic or amphoteric surfactants, active agents, fillers, polymers, propellants, basifying or acidifying agents or any other ingredient commonly used in the cosmetic and/or dermatological field.
- conventional cosmetic adjuvants chosen in particular from organic solvents, ionic or non-ionic thickeners, softeners, humectants, opacifiers, stabilizers, emollients, silicones, antifoams, fragrances, preservatives, anionic, cationic, non-ionic, zwitterionic or amphoteric surfactants, active agents, fillers, polymers, propellants
- C1-C4 monoalkanols as defined above and in particular short-chain C2-C8 polyols, such as glycerol or diols, such as caprylyl glycol, 1 ,2-pentanediol, propanediol, butanediol, glycols and glycol ethers, such as ethylene glycol, propylene glycol, butylene glycol, dipropylene glycol or diethylene glycol
- carboxyvinyl polymers such as the Carbopols® (Carbomers) and the Pemulens, such as Pemulen TR1® and Pemulen TR2® (acrylate/C10-C30 alkyl acrylate copolymer); polyacrylamides, for instance the crosslinked copolymers sold under the names Sepigel 305® (CTFA name: polyacrylamide/Ci3-i4 isoparaffin/Laureth 7) or Simulgel 600 (CTFA name: acrylamide/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate 80) by the company SEPPIC; 2- acrylamido-2-methylpropanesulfonic acid polymers and copolymers, optionally crosslinked and/or neutralized, such as the poly(2-acrylamido-2- methylpropanesulfonic acid) sold by the company Hoechst under the trade name Hostacerin AMPS®
- carboxyvinyl polymers such as the
- acidifying agents examples that may be mentioned include mineral or organic acids, for instance hydrochloric acid, orthophosphoric acid, sulfuric acid, carboxylic acids, for instance acetic acid, tartaric acid, citric acid or lactic acid, and sulfonic acids.
- mineral or organic acids for instance hydrochloric acid, orthophosphoric acid, sulfuric acid, carboxylic acids, for instance acetic acid, tartaric acid, citric acid or lactic acid, and sulfonic acids.
- basifying agents examples that may be mentioned include aqueous ammonia, alkali metal carbonates, alkanolamines, such as mono-, di- and triethanolamines and derivatives thereof, sodium hydroxide or potassium hydroxide.
- the cosmetic composition comprises one or more basifying agents chosen from alkanolamines, in particular triethanolamine, and sodium hydroxide.
- the pH of the composition in accordance with the invention is generally between 3 and 12 approximately, preferably between 5 and 11 approximately, and even more particularly from 5.5 to 8.
- active agents for caring for keratin materials such as the skin, the lips, the scalp, the hair, the eyelashes or the nails
- compositions according to the invention may be prepared according to the techniques that are well known to those skilled in the art. They may in particular be in the form of a simple or complex emulsion (O/W, W/O, O/W/O or W/O/W), such as a cream, a milk or a cream gel.
- a simple or complex emulsion O/W, W/O, O/W/O or W/O/W
- anhydrous composition is intended to mean a composition containing less than 1 % by weight of water, or even less than 0.5% water, and especially free of water, the water not being added during the preparation of the composition but corresponding to the residual water provided by the mixed ingredients. They may optionally be packaged in aerosol form and may be in the form of a mousse or a spray.
- the emulsification processes that may be used are of the paddle or impeller, rotor-stator and HPH type.
- the emulsions generally contain at least one emulsifier chosen from amphoteric, anionic, cationic or non-ionic emulsifiers, used alone or as a mixture.
- the emulsifiers are chosen in an appropriate manner according to the emulsion to be obtained (W/O or O/W emulsion).
- W/O emulsifying surfactants examples include alkyl esters or ethers of sorbitan, of glycerol, of polyol, of glycerol or of sugars; silicone surfactants, for instance dimethicone copolyols, such as the mixture of cyclomethicone and of dimethicone copolyol, sold under the name DC 5225 C® by the company Dow Coming, and alkyldimethicone copolyols such as laurylmethicone copolyol sold under the name Dow Coming 5200 Formulation Aid by the company Dow Coming; cetyldimethicone copolyol, such as the product sold under the name Abil EM 90R® by the company Goldschmidt, and the mixture of cetyldimethicone copolyol, of polyglyceryl isostearate (4 mol) and of hexyl laurate, sold under the name Abil WE 09® by the company Goldschmid
- non-silicone emulsifying surfactants in particular alkyl esters or ethers of sorbitan, of glycerol, of polyol or of sugars.
- Polyol alkyl esters that may in particular be mentioned include polyethylene glycol esters, for instance PEG-30 dipolyhydroxystearate, such as the product sold under the name Arlacel P135® by the company ICI.
- examples of glycerol and/or sorbitan esters that may be mentioned include polyglyceryl isostearate, such as the product sold under the name Isolan Gl 34® by the company Goldschmidt; sorbitan isostearate, such as the product sold under the name Arlacel 987® by the company ICI; sorbitan glyceryl isostearate, such as the product sold under the name Arlacel 986® by the company ICI, and mixtures thereof.
- non-ionic emulsifying surfactants examples include polyoxyalkylenated (more particularly polyoxyethylenated and/or polyoxypropylenated) esters of fatty acids and of glycerol; oxyalkylenated esters of fatty acids and of sorbitan; polyoxyalkylenated (in particular polyoxyethylenated and/or polyoxypropylenated) esters of fatty acids, optionally in combination with an ester of a fatty acid and of glycerol, such as the PEG-100 stearate/glyceryl stearate mixture sold, for example, by the company ICI under the name Arlacel 165; oxyalkylenated (oxyethylenated and/or oxypropylenated) ethers of fatty alcohols; esters of sugars, such as sucrose stearate; or ethers of fatty alcohol and of sugar, in particular
- the mixture of the alkyl polyglucoside as defined above with the corresponding fatty alcohol may be in the form of a self-emulsifying composition, for example as described in the document WO-A-92/06778.
- the aqueous phase of this emulsion may comprise a non-ionic vesicular dispersion prepared according to known processes (Bangham, Standish and Watkins, J. Mol. Biol. 13, 238 (1965), FR 2 315 991 and FR 2 416 008).
- the compositions according to the invention find their application in a large number of treatments, in particular cosmetic treatments, for the skin, the lips and the hair, including the scalp, in particular for protecting and/or caring for the skin, the lips and/or the hair, and/or for making up the skin and/or the lips.
- compositions according to the invention as defined above for the manufacture of products for the cosmetic treatment of the skin, the lips, the nails, the hair, the eyelashes, the eyebrows and/or the scalp, in particular care products, antisun products and makeup products.
- the cosmetic compositions according to the invention may be used, for example, as a makeup product.
- Another subject of the present invention is constituted of a non- therapeutic cosmetic process for caring for and/or making up a keratin material, which consists in applying, to the surface of said keratin material, at least one composition according to the invention as defined above.
- the cosmetic compositions according to the invention may be used, for example, as a care product and/or antisun product for the face and/or body, with a liquid to semi-liquid consistency, such as milks, more or less smooth creams, cream gels or pastes. They may optionally be packaged in aerosol form and may be in the form of a mousse or a spray.
- compositions according to the invention in the form of vaporizable fluid lotions in accordance with the invention are applied to the skin or hair in the form of fine particles by means of pressurizing devices.
- the devices in accordance with the invention are well known to those skilled in the art and comprise non-aerosol pumps or "atomizers", aerosol containers comprising a propellant and aerosol pumps using compressed air as propellant. These devices are described in patents US 4 077 441 and US 4 850 517.
- compositions packaged in aerosol form in accordance with the invention generally contain conventional propellants, for instance hydrofluoro compounds, dichlorodifluoromethane, difluoroethane, dimethyl ether, isobutane, n-butane, propane or trichlorofluoromethane. They are preferably present in amounts ranging from 15% to 50% by weight relative to the total weight of the composition.
- the invention also relates to a cosmetic assembly comprising: i) a container delimiting one or more compartments, said container being closed by a closing member and optionally being unsealed; and ii) a makeup and/or care composition in accordance with the invention placed inside said compartment(s).
- the container may be, for example, in the form of a jar or a box.
- the closing member may be in the form of a lid comprising a cap mounted so as to be able to move by translation or by pivoting relative to the container housing said makeup and/or care composition(s).
- composition ingredients are given as % by weight of starting materials, relative to the total weight of the composition.
- the completion of the alkylation reaction can be monitored for example by methods such as TLC, GC or HPLC.
- the crude product (15) is obtained in the form of a dark brown oil.
- the sample is prepared by preparing a solution of the polymer at 10 mg/ml in tetrahydrofuran. The sample is placed in an oven at 54°C for 10 minutes and then in an oscillating shaker for 60 minutes to aid dissolution. After visual inspection, the sample appears to be totally dissolved in the solvent.
- the sample prepared was analysed using two polypore 300x7.5 mm columns (manufactured by Agilent Technologies), a Waters 2695 chromatographic system, a tetrahydrofuran mobile phase and detection by refractive index.
- the sample was filtered through a 0.45 pm nylon filter, before being injected into the liguid chromatograph.
- the standards used for the calibration are the Easi Vial narrow polystyrene (PS) standards from Agilent Technologies.
- Polystyrene standards ranging from 2 520 000 to 162 daltons were used for the calibration.
- the system is eguipped with a PSS SECcurity 1260 Rl detector.
- the polystyrene calibration curve was used to determine the average molecular weight.
- the recording of the diagrams and the determination of the various molecular weights were performed by the Win GPC Unichrom 81 program.
- This method describes the general procedure for determining the melting point of polymers by differential scanning calorimetry. This method is based on the standards ASTM E791 and ASTM D 34182 and the DSC calibration is performed according to standard ASTM E 9672.
- the solvent was then removed by vacuum distillation, 1 g of dilauryl peroxide was then added and the reaction was continued for 60 minutes at 110°C. The step was repeated. The mixture was then cooled to 90°C, a stream of demineralized water was added and the mixture was then stirred. The water was removed by vacuum distillation.
- the solvent was then removed by vacuum distillation, 1 g of dilauryl peroxide was then added and the reaction was continued for 60 minutes at 125°C. The step was repeated. The mixture was then cooled to 90°C, a stream of demineralized water was added and the mixture was then stirred. The water was removed by vacuum distillation.
- solubility of merocyanine in the oily solutions can be evaluated macroscopically and/or microscopically. It is considered that the merocyanine is soluble if, at ambient temperature, the solution appears to the eye to be clear and translucent, and it does not have any visible crystals under a whitelight or polarized-light microscope (objective *20 to *40).
- the solubility is evaluated macroscopically. It is evaluated at ambient temperature, on the day the solution is prepared and then over time. During this time period, the solutions are stored at ambient temperature or at 4°C.
- compositions described in Examples 1 and 9 are prepared in the following way: the screening agents and the oils are introduced successively into a container, before being stirred by means of a magnetic stirrer and being heated at from 80 to 90°C for between 10 min and 1 hour, until the merocyanine has dissolved.
- the aqueous phase A is prepared by mixing all the starting materials at 65°C until a homogeneous phase is obtained.
- Phase B is mixed in several stages: phase B1 is mixed at 80°C until a homogeneous phase is obtained.
- Phase B2 is then introduced at 75°C, and then phase B3 at 65°C.
- the emulsion is prepared by introducing phase B into phase A with vigorous stirring for 10 min at 65°C.
- Phase C is then introduced at 55°C and the mixture is left to homogenize for 5 minutes.
- Phase D is then introduced at 25°C.
- the aqueous phase A is prepared by mixing all the starting materials at 65°C until a homogeneous phase is obtained.
- Phase B is mixed in several stages: phase B1 is mixed at 80°C until a homogeneous phase is obtained.
- Phase B2 is then introduced at 65°C.
- the emulsion is prepared by introducing phase B into phase A with vigorous stirring for 10 minutes at 65°C.
- the emulsion is then cooled to 35°C, while maintaining stirring, and then phase C is introduced (stirring for 10 minutes).
- Phase D is then added, then phase E, with stirring.
- phase F is introduced at 25°C.
- the final emulsion is characterized by drops of 1 pm to 20 pm.
- aqueous phase A is prepared by mixing all the starting materials at 65°C until a homogeneous phase is obtained.
- Phase B is mixed in several stages: phase B1 is mixed at 80°C until a homogeneous phase is obtained.
- phase B2 is added and then phase B3 at65°C.
- the emulsion is prepared by introducing phase B into phase A with vigorous stirring for 10 minutes at 65°C.
- the emulsion is then cooled to 25°C, while maintaining stirring, and then phase C is introduced.
- the final emulsion is characterized by drops of 1 pm to 20 pm.
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Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21836527.8A EP4262719A1 (en) | 2020-12-18 | 2021-12-14 | Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one citric acid ester |
MX2023007261A MX2023007261A (en) | 2020-12-18 | 2021-12-14 | Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one citric acid ester. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FRFR2013605 | 2020-12-18 | ||
FR2013605A FR3117824A1 (en) | 2020-12-18 | 2020-12-18 | Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one citric acid ester |
Publications (1)
Publication Number | Publication Date |
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WO2022129059A1 true WO2022129059A1 (en) | 2022-06-23 |
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ID=74759027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2021/085710 WO2022129059A1 (en) | 2020-12-18 | 2021-12-14 | Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one citric acid ester |
Country Status (4)
Country | Link |
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EP (1) | EP4262719A1 (en) |
FR (1) | FR3117824A1 (en) |
MX (1) | MX2023007261A (en) |
WO (1) | WO2022129059A1 (en) |
Citations (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2463264A (en) | 1942-12-23 | 1949-03-01 | Ciba Ltd | Derivatives of cyclic amidines and process of making same |
FR2315991A1 (en) | 1975-06-30 | 1977-01-28 | Oreal | METHOD OF MANUFACTURING AQUEOUS DISPERSIONS OF LIPID SPHERULES AND CORRESPONDING NEW COMPOSITIONS |
US4077441A (en) | 1976-08-16 | 1978-03-07 | National Instrument Company | Convertible filling machine |
FR2416008A1 (en) | 1978-02-02 | 1979-08-31 | Oreal | LIPOSOME LYOPHILISATES |
US4195999A (en) | 1977-04-15 | 1980-04-01 | Fuji Photo Film Co., Ltd. | Silver halide photographic material containing ultraviolet light absorbing agent |
EP0133981A2 (en) | 1983-08-05 | 1985-03-13 | Siemens Aktiengesellschaft | Mechanical overload protection |
US4749643A (en) | 1985-09-03 | 1988-06-07 | Agfa Gevaert Aktiengesellschaft | Photographic recording element containing a UV absorbent and a silver halide emulsion layer |
US4850517A (en) | 1985-09-27 | 1989-07-25 | Airspray International B.V. | Pressurized spray dispenser having valved mixing chamber |
WO1992006778A1 (en) | 1990-10-17 | 1992-04-30 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Use of fatty alcohol based compositions for preparing emulsions, method of preparing emulsions and emulsions so obtained |
US5166355A (en) | 1991-02-04 | 1992-11-24 | Fairmount Chemical Co., Inc. | Process for preparing substituted 2,2'-methylene-bis-[6-(2H-benzotriazol-2-yl)-4-hydrocarbyl-phenols] |
EP0518773A1 (en) | 1991-06-14 | 1992-12-16 | L'oreal | Cosmetic composition containing a blend of metallic oxids nanopigments and melanic pigments |
WO1993004665A1 (en) | 1991-08-29 | 1993-03-18 | L'oreal | Filtering cosmetic composition containing a liposoluble filter polymer with hydrocarbonated structure and a filter silicone |
US5237071A (en) | 1991-01-22 | 1993-08-17 | Fairmount Chemical Company, Inc. | Process for preparing 2,2'-methylene-bis(6-(2H-benzotriazol-2-yl)-4-hydrocarbyl phenols) |
EP0669323A1 (en) | 1994-02-24 | 1995-08-30 | Haarmann & Reimer Gmbh | Utilization of benzazols as UV-absorbers, new benzazoles and process for their preparation |
GB2303549A (en) | 1995-07-22 | 1997-02-26 | Ciba Geigy Ag | Micronising organic UV absorbers with alkyl polyglucosides |
US5624663A (en) | 1987-08-28 | 1997-04-29 | L'oreal | Photostable cosmetic filter composition cotaining a UV-A filter and a substituted dialkylbenzalmalonate, the use of substituted dialkylbenzalmalonates in cosmetics as broad-band solar filters and novel substituted dialkyl malonates |
EP0832642A2 (en) | 1996-09-13 | 1998-04-01 | 3V SIGMA S.p.A | Derivatives of Benzoxazole useful as uv filters |
EP0841341A1 (en) | 1996-11-08 | 1998-05-13 | L'oreal | Sunscreen agents, and cosmetic compositions containing them |
DE19726184A1 (en) | 1997-06-20 | 1998-12-24 | Beiersdorf Ag | Oil-in-water or multiple emulsion with high concentration of suspended UVB filter |
EP0893119A1 (en) | 1997-07-26 | 1999-01-27 | Ciba SC Holding AG | UV-protection formulation |
DE19746654A1 (en) | 1997-08-13 | 1999-02-18 | Basf Ag | Use of 4,4-di:aryl-butadiene derivatives as photostable UV filter compounds |
DE19755649A1 (en) | 1997-12-15 | 1999-06-17 | Basf Ag | Use of 4,4-diarylbutadienes as photostable UV filters in cosmetics |
EP0967200A1 (en) | 1998-06-26 | 1999-12-29 | Basf Aktiengesellschaft | 4,4-Diarylbutadienes as water soluble, photostable UV-filters for cosmetic and pharmaceutical preparations |
DE19855649A1 (en) | 1998-12-03 | 2000-06-08 | Basf Ag | Dimeric alpha-alkyl-styrene derivatives as photostable UV filters in cosmetic and pharmaceutical preparations |
EP1008586A1 (en) | 1998-12-11 | 2000-06-14 | Basf Aktiengesellschaft | Oligomeric diarylbutadienes |
EP1027883A2 (en) | 1999-01-11 | 2000-08-16 | 3V SIGMA S.p.A | Combinations of sunscreen agents with UV-A and UV-B filtering properties |
US6225467B1 (en) | 2000-01-21 | 2001-05-01 | Xerox Corporation | Electroluminescent (EL) devices |
EP1133980A2 (en) | 2000-03-15 | 2001-09-19 | Basf Aktiengesellschaft | Use of combinations of photoprotectors comprising as essential components aminosubstituted hydroxybenzophenones as photostable UV-filters in cosmetic and pharmaceutical preparations |
WO2002034710A2 (en) | 2000-10-26 | 2002-05-02 | Centre National De La Recherche Scientifique (Cnrs) | Novel intermediates for use in retinoid synthesis |
EP1300137A2 (en) | 2001-10-02 | 2003-04-09 | 3V SIGMA S.p.A | Combinations of sunscreens |
DE10162844A1 (en) | 2001-12-20 | 2003-07-03 | Beiersdorf Ag | Cosmetic and dermatological light protection formulations containing bis-resorcinyltriazine derivatives and benzoxazole derivatives |
US20030181483A1 (en) | 2002-03-25 | 2003-09-25 | Akihiko Ikegawa | Method for producing delta-aminopentadienoate derivatives |
WO2004006878A1 (en) | 2002-07-10 | 2004-01-22 | Ciba Specialty Chemicals Holding Inc. | Merocyanine derivatives for cosmetic use |
WO2004085412A2 (en) | 2003-03-24 | 2004-10-07 | Ciba Specialty Chemicals Holding Inc. | Symmetrical triazine derivatives |
WO2006035007A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | Cosmetic light-block preparation made from micropigments |
WO2006034985A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | O/w emulsion comprising inorganic uv filter pigments and alkyl sulfate |
WO2006035000A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | Sun protection emulsion comprising a high fraction of sun protection filter pigments |
WO2006034991A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | W/o emulsion comprising uv filter pigments |
WO2006034992A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | Cosmetic sunscreen emulsions containing organic micropigments |
WO2006034982A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | Light-block concentrate with organic micropigments |
WO2007068371A1 (en) | 2005-12-14 | 2007-06-21 | Cognis Ip Management Gmbh | Method for producing hydrocarbons |
WO2007071584A2 (en) | 2005-12-21 | 2007-06-28 | Ciba Holding Inc. | Use of transmission dyes for protecting human skin from browning and ageing |
WO2007071582A1 (en) | 2005-12-20 | 2007-06-28 | Ciba Holding Inc. | Merocyanine derivatives |
US20070264204A1 (en) | 2006-05-11 | 2007-11-15 | Air Products And Chemicals, Inc. | Personal care compositions containing functionalized polymers |
WO2008155059A2 (en) | 2007-06-19 | 2008-12-24 | Cognis Ip Management Gmbh | Hydrocarbon mixtures and use thereof |
WO2009063392A2 (en) | 2007-11-12 | 2009-05-22 | Basf Se | Ultraviolet absorber water-dispersed composition |
WO2013011094A2 (en) | 2011-07-21 | 2013-01-24 | L'oreal | Cosmetic and/or dermatological composition containing a merocyanine derivative comprising specific polar groups consisting of hydroxyl- and ether-functionalities |
FR3046929A1 (en) * | 2016-01-26 | 2017-07-28 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AN OILY PHASE COMPRISING AT LEAST ONE DI OR TRICARBOXYLIC ACID ESTER |
-
2020
- 2020-12-18 FR FR2013605A patent/FR3117824A1/en active Pending
-
2021
- 2021-12-14 WO PCT/EP2021/085710 patent/WO2022129059A1/en active Application Filing
- 2021-12-14 EP EP21836527.8A patent/EP4262719A1/en active Pending
- 2021-12-14 MX MX2023007261A patent/MX2023007261A/en unknown
Patent Citations (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2463264A (en) | 1942-12-23 | 1949-03-01 | Ciba Ltd | Derivatives of cyclic amidines and process of making same |
FR2315991A1 (en) | 1975-06-30 | 1977-01-28 | Oreal | METHOD OF MANUFACTURING AQUEOUS DISPERSIONS OF LIPID SPHERULES AND CORRESPONDING NEW COMPOSITIONS |
US4077441A (en) | 1976-08-16 | 1978-03-07 | National Instrument Company | Convertible filling machine |
US4195999A (en) | 1977-04-15 | 1980-04-01 | Fuji Photo Film Co., Ltd. | Silver halide photographic material containing ultraviolet light absorbing agent |
FR2416008A1 (en) | 1978-02-02 | 1979-08-31 | Oreal | LIPOSOME LYOPHILISATES |
EP0133981A2 (en) | 1983-08-05 | 1985-03-13 | Siemens Aktiengesellschaft | Mechanical overload protection |
US4749643A (en) | 1985-09-03 | 1988-06-07 | Agfa Gevaert Aktiengesellschaft | Photographic recording element containing a UV absorbent and a silver halide emulsion layer |
US4850517A (en) | 1985-09-27 | 1989-07-25 | Airspray International B.V. | Pressurized spray dispenser having valved mixing chamber |
US5624663A (en) | 1987-08-28 | 1997-04-29 | L'oreal | Photostable cosmetic filter composition cotaining a UV-A filter and a substituted dialkylbenzalmalonate, the use of substituted dialkylbenzalmalonates in cosmetics as broad-band solar filters and novel substituted dialkyl malonates |
WO1992006778A1 (en) | 1990-10-17 | 1992-04-30 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Use of fatty alcohol based compositions for preparing emulsions, method of preparing emulsions and emulsions so obtained |
US5237071A (en) | 1991-01-22 | 1993-08-17 | Fairmount Chemical Company, Inc. | Process for preparing 2,2'-methylene-bis(6-(2H-benzotriazol-2-yl)-4-hydrocarbyl phenols) |
US5166355A (en) | 1991-02-04 | 1992-11-24 | Fairmount Chemical Co., Inc. | Process for preparing substituted 2,2'-methylene-bis-[6-(2H-benzotriazol-2-yl)-4-hydrocarbyl-phenols] |
EP0518773A1 (en) | 1991-06-14 | 1992-12-16 | L'oreal | Cosmetic composition containing a blend of metallic oxids nanopigments and melanic pigments |
WO1993004665A1 (en) | 1991-08-29 | 1993-03-18 | L'oreal | Filtering cosmetic composition containing a liposoluble filter polymer with hydrocarbonated structure and a filter silicone |
EP0669323A1 (en) | 1994-02-24 | 1995-08-30 | Haarmann & Reimer Gmbh | Utilization of benzazols as UV-absorbers, new benzazoles and process for their preparation |
GB2303549A (en) | 1995-07-22 | 1997-02-26 | Ciba Geigy Ag | Micronising organic UV absorbers with alkyl polyglucosides |
EP0832642A2 (en) | 1996-09-13 | 1998-04-01 | 3V SIGMA S.p.A | Derivatives of Benzoxazole useful as uv filters |
EP0841341A1 (en) | 1996-11-08 | 1998-05-13 | L'oreal | Sunscreen agents, and cosmetic compositions containing them |
DE19726184A1 (en) | 1997-06-20 | 1998-12-24 | Beiersdorf Ag | Oil-in-water or multiple emulsion with high concentration of suspended UVB filter |
EP0893119A1 (en) | 1997-07-26 | 1999-01-27 | Ciba SC Holding AG | UV-protection formulation |
DE19746654A1 (en) | 1997-08-13 | 1999-02-18 | Basf Ag | Use of 4,4-di:aryl-butadiene derivatives as photostable UV filter compounds |
DE19755649A1 (en) | 1997-12-15 | 1999-06-17 | Basf Ag | Use of 4,4-diarylbutadienes as photostable UV filters in cosmetics |
EP0967200A1 (en) | 1998-06-26 | 1999-12-29 | Basf Aktiengesellschaft | 4,4-Diarylbutadienes as water soluble, photostable UV-filters for cosmetic and pharmaceutical preparations |
DE19855649A1 (en) | 1998-12-03 | 2000-06-08 | Basf Ag | Dimeric alpha-alkyl-styrene derivatives as photostable UV filters in cosmetic and pharmaceutical preparations |
EP1008586A1 (en) | 1998-12-11 | 2000-06-14 | Basf Aktiengesellschaft | Oligomeric diarylbutadienes |
EP1027883A2 (en) | 1999-01-11 | 2000-08-16 | 3V SIGMA S.p.A | Combinations of sunscreen agents with UV-A and UV-B filtering properties |
US6225467B1 (en) | 2000-01-21 | 2001-05-01 | Xerox Corporation | Electroluminescent (EL) devices |
EP1133980A2 (en) | 2000-03-15 | 2001-09-19 | Basf Aktiengesellschaft | Use of combinations of photoprotectors comprising as essential components aminosubstituted hydroxybenzophenones as photostable UV-filters in cosmetic and pharmaceutical preparations |
WO2002034710A2 (en) | 2000-10-26 | 2002-05-02 | Centre National De La Recherche Scientifique (Cnrs) | Novel intermediates for use in retinoid synthesis |
EP1300137A2 (en) | 2001-10-02 | 2003-04-09 | 3V SIGMA S.p.A | Combinations of sunscreens |
DE10162844A1 (en) | 2001-12-20 | 2003-07-03 | Beiersdorf Ag | Cosmetic and dermatological light protection formulations containing bis-resorcinyltriazine derivatives and benzoxazole derivatives |
US20030181483A1 (en) | 2002-03-25 | 2003-09-25 | Akihiko Ikegawa | Method for producing delta-aminopentadienoate derivatives |
WO2004006878A1 (en) | 2002-07-10 | 2004-01-22 | Ciba Specialty Chemicals Holding Inc. | Merocyanine derivatives for cosmetic use |
WO2004085412A2 (en) | 2003-03-24 | 2004-10-07 | Ciba Specialty Chemicals Holding Inc. | Symmetrical triazine derivatives |
WO2006034985A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | O/w emulsion comprising inorganic uv filter pigments and alkyl sulfate |
WO2006035000A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | Sun protection emulsion comprising a high fraction of sun protection filter pigments |
WO2006034991A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | W/o emulsion comprising uv filter pigments |
WO2006034992A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | Cosmetic sunscreen emulsions containing organic micropigments |
WO2006034982A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | Light-block concentrate with organic micropigments |
WO2006035007A1 (en) | 2004-09-27 | 2006-04-06 | Beiersdorf Ag | Cosmetic light-block preparation made from micropigments |
WO2007068371A1 (en) | 2005-12-14 | 2007-06-21 | Cognis Ip Management Gmbh | Method for producing hydrocarbons |
WO2007071582A1 (en) | 2005-12-20 | 2007-06-28 | Ciba Holding Inc. | Merocyanine derivatives |
WO2007071584A2 (en) | 2005-12-21 | 2007-06-28 | Ciba Holding Inc. | Use of transmission dyes for protecting human skin from browning and ageing |
US20070264204A1 (en) | 2006-05-11 | 2007-11-15 | Air Products And Chemicals, Inc. | Personal care compositions containing functionalized polymers |
WO2008155059A2 (en) | 2007-06-19 | 2008-12-24 | Cognis Ip Management Gmbh | Hydrocarbon mixtures and use thereof |
WO2009063392A2 (en) | 2007-11-12 | 2009-05-22 | Basf Se | Ultraviolet absorber water-dispersed composition |
WO2013011094A2 (en) | 2011-07-21 | 2013-01-24 | L'oreal | Cosmetic and/or dermatological composition containing a merocyanine derivative comprising specific polar groups consisting of hydroxyl- and ether-functionalities |
FR3046929A1 (en) * | 2016-01-26 | 2017-07-28 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AN OILY PHASE COMPRISING AT LEAST ONE DI OR TRICARBOXYLIC ACID ESTER |
Non-Patent Citations (12)
Title |
---|
B. WINKLER ET AL., TETRAHEDRON LETTERS, vol. 55, 2014, pages 1749 - 1751 |
BANGHAMSTANDISHWATKINS, J. MOL. BIOL., vol. 13, 1965, pages 238 |
CHEM. HETEROCYCL. COMP. (ENGLISH TRANSLATION, vol. 24, no. 8, 1988, pages 914 - 919 |
EUR. J. ORG. CHEM., 2003, pages 2250 - 2253 |
J. HETEROCYCL. CHEM., vol. 33, no. 3, 1996, pages 763 - 766 |
J. HETEROCYCLIC CHEM., vol. 27, 1990, pages 1143 - 1151 |
J. MED. CHEM., vol. 39, 1996, pages 1112 - 1124 |
J. ORG. CHEM. USSR (ENGLISH TRANSLATION, vol. 26, no. 8, 1990, pages 1562f |
J. ORG. CHEM., vol. 37, no. 8, 1972, pages 1141 - 1145 |
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, vol. 11, 1984, pages 1537 - 1543 |
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, vol. 3, 1982, pages 397 - 404 |
SYNTHETIC COMMUNICATIONS, vol. 33, no. 3, 2003, pages 367 - 371 |
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