WO2022111642A9 - Method for preparing acylated derivative of insulin or of analog thereof - Google Patents
Method for preparing acylated derivative of insulin or of analog thereof Download PDFInfo
- Publication number
- WO2022111642A9 WO2022111642A9 PCT/CN2021/133639 CN2021133639W WO2022111642A9 WO 2022111642 A9 WO2022111642 A9 WO 2022111642A9 CN 2021133639 W CN2021133639 W CN 2021133639W WO 2022111642 A9 WO2022111642 A9 WO 2022111642A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- insulin
- analog
- acylated derivative
- preparing
- preparing acylated
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present disclosure provides a method for preparing an acylated derivative of insulin or of an analog thereof, comprising the step of reacting insulin or an analog thereof with the compound of formula (I), and also provides the compound of formula (I) and a method for preparation thereof. The method of the present disclosure has a high yield and a stable process, can significantly reduce the cost of production of acylated derivatives of insulin or its analogs, and enables commercial production on a large scale.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202180079085.5A CN116583531A (en) | 2020-11-27 | 2021-11-26 | Method for preparing acylated derivatives of insulin or analogues thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011355289.0 | 2020-11-27 | ||
| CN202011355289 | 2020-11-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2022111642A1 WO2022111642A1 (en) | 2022-06-02 |
| WO2022111642A9 true WO2022111642A9 (en) | 2022-07-07 |
Family
ID=81755327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2021/133639 WO2022111642A1 (en) | 2020-11-27 | 2021-11-26 | Method for preparing acylated derivative of insulin or of analog thereof |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN116583531A (en) |
| TW (1) | TW202229324A (en) |
| WO (1) | WO2022111642A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1969004T3 (en) * | 2005-12-28 | 2012-01-31 | Novo Nordisk As | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| CN106496322A (en) * | 2015-09-07 | 2017-03-15 | 江苏恒瑞医药股份有限公司 | The preparation method of the acylated derivatives of insulin human or its analog |
| WO2018024186A1 (en) * | 2016-08-02 | 2018-02-08 | 江苏恒瑞医药股份有限公司 | Acylated derivative of human insulin or analogue thereof |
| MX2020008129A (en) * | 2018-02-01 | 2020-09-18 | Jiangsu Hengrui Medicine Co | Pharmaceutical composition comprising acylated derivative of human insulin analog and preparation method thereof. |
-
2021
- 2021-11-26 CN CN202180079085.5A patent/CN116583531A/en active Pending
- 2021-11-26 TW TW110144275A patent/TW202229324A/en unknown
- 2021-11-26 WO PCT/CN2021/133639 patent/WO2022111642A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| TW202229324A (en) | 2022-08-01 |
| CN116583531A (en) | 2023-08-11 |
| WO2022111642A1 (en) | 2022-06-02 |
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