WO2022111497A1

WO2022111497A1 - Application of iodine in preparation of drugs for preventing and treating respiratory tract infectious diseases

Info

Publication number: WO2022111497A1
Application number: PCT/CN2021/132640
Authority: WO
Inventors: 金玉东
Original assignee: 金玉东
Priority date: 2020-11-27
Filing date: 2021-11-24
Publication date: 2022-06-02
Also published as: CN112791097A

Abstract

An application of iodine in preparation of drugs for preventing and treating respiratory tract infectious diseases. Iodine is separately dissolved in pure water and an oily solvent to prepare two types of low-concentration iodine solutions, so as to obtain two types of iodine solution spray agents, which are nebulized into an iodine-containing aerosol by a nebulizer and then inhaled into respiratory tracts.

Description

Application of iodine in the preparation of medicines for the prevention and treatment of respiratory infectious diseases

technical field

The invention relates to the technical field of medicine, in particular to the application of iodine in the preparation of a medicine for preventing and treating respiratory infectious diseases.

Background technique

The respiratory tract is composed of the nasal cavity, throat, trachea, bronchioles, respiratory bronchioles, alveolar ducts, and alveoli. During inhalation, gas enters the alveoli from the nasal cavity, conducts gas exchange, and then exhales. Pathogens attack from the nasal cavity to the alveoli, resulting in rhinitis (common cold), pharyngitis, tracheo-bronchitis, and pneumonia. Common pathogens that cause respiratory tract infections include viruses, bacteria, mycoplasma, chlamydia, and fungi. Viruses include respiratory syncytial virus, adenovirus, rhinovirus, coronavirus, influenza A virus, influenza B virus, SARS virus, avian influenza virus, new coronavirus, etc.

For respiratory viral infections, there is a worldwide lack of effective treatments. There is a large-scale outbreak of new coronary pneumonia in the world. The virus invades the nasal mucosa to multiply in the alveoli. Humans are helpless, watching the new coronary pneumonia from mild to severe, critical, and dying. Respiratory tract infections caused by bacteria, mycoplasma, chlamydia, fungi, etc. can be resisted by antibiotics, but with the continuous emergence of drug-resistant bacteria, it has become a difficult problem in modern medicine.

The new coronavirus (2019-nCoV) is a new strain of coronavirus. After infecting the human body, symptoms such as fever, cough, shortness of breath, and dyspnea can occur, which can lead to pneumonia, acute respiratory distress syndrome, renal failure, etc., and even death. There is currently no effective treatment for the new coronavirus. In the "Diagnosis and Treatment Program for Novel Coronavirus Infected Pneumonia (Trial Version 4)" issued by the state, the use of interferon inhalation, lopinavir and ritonavir antiviral therapy was considered, but the efficacy was poor. Due to the lack of effective drugs for the treatment of new coronary pneumonia, drug development is particularly important.

Iodine is a strong oxidant, which can halogenate the proteins of pathogenic microorganisms such as viruses, bacteria, fungi, etc., destroy their protoplasmic protein active groups, and combine with the amino acids of proteins to denature them and lose their activity. It has a strong killing effect. Moreover, iodine has a very strong penetrating power to viruses, bacteria, etc., and has a rapid effect. If iodine is used to kill respiratory infectious viruses, including the new coronavirus, there will be surprises. However, after oral administration or injection of iodine, it is quickly reduced to iodine ions and loses biological activity, so it cannot reach the lungs with blood circulation to function. Therefore, iodine has not been clinically used in the treatment of respiratory infectious diseases. However, respiratory virus infections, such as new coronary pneumonia, bird flu, influenza A, influenza B and other severe infectious diseases, and the lack of effective therapeutic drugs, pose a great threat to human life safety. Bacterial, mycoplasma, chlamydia, and fungal respiratory infections are particularly intractable due to drug resistance. There is an urgent need for a specific drug that can quickly kill respiratory infectious pathogenic microorganisms. If iodine is prepared into aerosols and inhaled, tens of billions of active iodine molecules are directly pushed into the respiratory tract to deal with millions of viruses. To easily kill the virus in the trachea and alveoli, the key is to prepare iodine so that it has no stimulating effect on the mucous membrane of the respiratory tract. So far, this iodine preparation that can be inhaled by aerosol is still blank in the world.

Iodine is a disinfectant and corrosion drug, and there are currently three preparations: cidi iodine lozenges, iodine glycerin and iodine tincture. Cidi iodine is composed of iodine molecules. Each tablet contains 1.5mg of iodine, a very small amount. It is taken orally. It is used to treat chronic pharyngitis, oral ulcers, chronic gingivitis, and periodontitis. It has been used clinically for decades. It has been proved that this dose of iodine taken orally is safe for the human body, and it is not irritating to the mucous membranes. Iodine glycerin contains 10mg of iodine per milliliter. It is applied to the oral mucosa for the treatment of oral ulcers, gingivitis, and periodontitis. It has also been used for decades, indicating that it is safe. The effective concentration of iodine to kill pathogenic microorganisms is 0.001%, which reduces the iodine content of iodine glycerol by 100 times, that is, 0.01%, which is 10 times the effective concentration. Kill pathogenic microorganisms, and this low-concentration iodine solution has little irritation to mucous membranes, and can be safely inhaled through the respiratory tract to kill pathogens through atomization, filling the gap in the treatment of respiratory infectious diseases.

In iodine-containing disinfectant, iodine tincture concentration: 2%, formula: iodine, alcohol, potassium iodide, water; iodine glycerol concentration: 1%, formula: iodine, potassium iodide, glycerin, water; iodine water (now discarded) concentration: 1%, formula: iodine, potassium iodide, water, but the effective concentration of iodine to kill pathogenic microorganisms is 0.001%. The concentration of iodine tincture is 2,000 times of the effective concentration, and the killing of pathogens is overwhelming. The preparation of iodine into a disinfectant with a common concentration of 0.015% can not only effectively kill pathogens, but also greatly reduce irritation, which is a great innovation in the application of iodine disinfectant.

In view of the above description, there is an urgent need to prepare a medicine that can efficiently kill pathogens that cause respiratory tract infections, and a safer low-concentration iodine disinfectant.

SUMMARY OF THE INVENTION

In order to solve one or more problems existing in the prior art, the present invention provides an application of iodine in the preparation of a medicament for preventing and treating respiratory infectious diseases.

The technical scheme adopted by the present invention to achieve the above purpose is as follows: the present invention proposes an application of iodine in the preparation of a medicament for preventing and treating respiratory infectious diseases.

In some embodiments, the respiratory tract infection refers to respiratory tract infections caused by viruses, bacteria, mycoplasma, chlamydia, and fungi, including common cold, pharyngitis, tracheo-bronchitis, pneumonia, influenza A, influenza B, Avian flu and COVID-19.

In some embodiments, the iodine is an element or molecule of iodine, and the element or molecule of iodine is made into a low-concentration iodine solution.

The invention also proposes an application of iodine in preparing low-concentration iodine disinfectant.

In some embodiments, the concentration of the low-concentration iodine disinfectant is lower than 0.5%.

The present invention also provides a method for preparing a small particle size iodine-containing aerosol, which comprises atomizing or granulating it.

In some embodiments, the atomizing includes:

Step S11: mixing elemental iodine and purified water;

Step S12: preparing the iodine element and purified water into an iodine solution;

Step S13: passing the iodine solution through an atomizing device to form a small particle size iodine-containing aerosol;

Step S14: inhaling the atomized iodine-containing aerosol into the alveoli;

Step S15: The iodine in the iodine-containing aerosol kills pathogenic microorganisms.

In some embodiments, the common concentration of the iodine solution is 0.015%.

In some embodiments, the granulating comprises:

Step S21: mixing iodine element and oily liquid;

Step S22: preparing the iodine element and the oily liquid into an iodine solution;

Step S23: atomizing the iodine solution by an electronic atomizer to form a small particle size iodine-containing aerosol;

Step S24: inhaling the atomized iodine-containing aerosol into the alveoli;

Step S25: the iodine in the iodine-containing aerosol kills pathogenic microorganisms.

In some embodiments, the step 21 is carried out according to the ratio of mixing 20 mg of iodine element per 1 ml of oily liquid.

The beneficial effects of the invention are: iodine can efficiently kill various pathogens, and it was mainly used in the sterilization of skin and oral mucosa in the human body before. In the present invention, iodine is prepared into a low-concentration iodine solution as an atomizing agent, which is atomized into an iodine-containing aerosol and inhaled into the respiratory tract, which can not only ensure the killing of pathogenic microorganisms, but also minimize the stimulating effect on the mucous membrane, so that iodine can be applied to respiratory tract infections. Treatment of sexually transmitted diseases becomes a reality. Through aerosol inhalation, iodine quickly and efficiently kills pathogenic microorganisms that multiply abnormally in the respiratory tract, and becomes a special medicine for respiratory infectious diseases. At present, there is a lack of effective drugs for respiratory viral infections in the world, and the successfully prepared low-concentration iodine aerosol is a special drug. After inhalation, it can easily kill various viruses and quickly control influenza A and B. Influenza, bird flu, new coronary pneumonia and other serious infectious diseases. Especially for the new coronary pneumonia, low-concentration iodine aerosol inhalation is used to inhale the alveoli, and active iodine vigorously kills the new coronavirus, so that mild cases can be quickly recovered, and severe and critical cases can be quickly out of danger, saving countless lives. Even if the new coronavirus mutates greatly in the future, or other respiratory infectious diseases appear, it can be solved by inhalation of low-concentration iodine aerosol to avoid panic. Low-concentration iodine aerosol inhalation also provides an efficient and simple treatment method for other pathogens such as common viruses and bacteria in the respiratory tract, and can also solve the problem of drug resistance. It is a subversive revolution in the treatment of respiratory infectious diseases. In the face of any respiratory infectious disease in the future, human beings can be calm, because they have a powerful weapon to efficiently eliminate pathogens.

The prepared low-concentration iodine disinfectant is less irritating, safer and has a wider application range.

Description of drawings

Fig. 1 is the flow chart of a kind of method of preparing low particle size iodine-containing aerosol of the preferred embodiment of the present invention;

2 is a flow chart of a method for preparing a low particle size iodine-containing aerosol according to another preferred embodiment of the present invention.

Detailed ways

In order to make the objects, features and advantages of the present invention more comprehensible, the specific embodiments of the present invention are described in detail with reference to the accompanying drawings, and many specific details are set forth so as to be fully understood. The present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make corresponding improvements without departing from the connotation of the present invention. Therefore, the present invention is not limited by the specific embodiments disclosed below.

The invention proposes the application of iodine in the preparation of medicines for preventing and treating respiratory infectious diseases.

Specifically, in this scheme, iodine is dissolved in pure water and glycerin, and two types of iodine solution atomizers are respectively prepared, which are atomized into iodine-containing aerosols by the atomizer and inhaled into the respiratory tract to kill pathogens quickly and efficiently. It is the only specific drug for the treatment of respiratory viral infections, and provides more effective and convenient therapeutic drugs for respiratory bacteria, mycoplasma, fungi and other infections.

In some embodiments, the respiratory tract infection refers to respiratory tract infections caused by viruses, bacteria, mycoplasma, chlamydia, fungi, etc., including common cold, pharyngitis, tracheo-bronchitis, pneumonia, influenza A, influenza B , bird flu, new coronary pneumonia, and other respiratory infectious diseases in the future.

The invention also proposes the application of iodine in the preparation of low-concentration disinfectant.

In some embodiments, the concentration of the low-concentration iodine disinfectant is lower than 0.5%, and the common concentration is 0.015%.

Referring to Figure 1, the atomization includes:

In some embodiments, the atomizing includes:

Step S11: iodine elemental substance and pure water are mixed;

Step S12: iodine elemental substance and pure water are prepared into iodine solution;

Step S13: the iodine solution is formed into a small particle size iodine-containing aerosol by atomizing device;

Step S14: the iodine-containing aerosol after the atomization is inhaled into the alveoli;

In some embodiments, the concentration of the iodine solution is 0.015%.

Specifically, in this embodiment, iodine is dissolved in pure water, and it is prepared into a 0.015% low-concentration iodine solution, which is atomized and inhaled three times a day. Compression nebulizer is selected, the fog particles are fine and the median particle size (MMD) is about 2.2μm to ensure that a certain proportion of aerosol can reach the alveoli. The iodine is prepared into a very low concentration solution of 0.015%, and then atomized into an aerosol, which greatly reduces the density of iodine, greatly reduces the irritation of iodine, and can safely enter the respiratory tract.

Referring to Figure 2, the granulation includes:

In some embodiments, the granulating comprises:

Step S21: mixing elemental iodine and glycerol;

Step S22: preparing an iodine solution from elemental iodine and glycerol;

Step S23: atomizing the iodine solution by an electronic atomizer to form a low particle size iodine-containing aerosol;

Step S24: inhaling the atomized iodine-containing aerosol into the alveoli;

In some embodiments, the step 21 is performed according to the ratio of mixing 20 mg of iodine element per 1 ml of glycerol.

The diameter of the particles entering the alveoli needs to be less than 2.25 μm. Since the compressed atomization inhalation cannot fully meet this requirement, some iodine cannot enter the alveoli.

In this embodiment, an electronic atomizer is used to turn the glycerol-iodine solution into a smoke-like aerosol with a particle size of less than 2.25 μm, which can smoothly enter the alveoli and greatly improve the therapeutic effect of pulmonary infection.

Specifically, in this embodiment, iodine and glycerin are mixed in a ratio of 20mg: 1ml to prepare a glycerol-iodine solution, which is transformed into a smoke-like iodine-containing aerosol by an electronic atomizer. Three times a day. 2ml of glycerol-iodine solution can suck 400 large mouths. This method can ensure that most of the iodine-containing aerosol enters the alveoli, allowing iodine to fully exert its killing effect. The preparation of iodine into aerosol can greatly reduce the density of iodine, greatly reduce the irritation, and make it a reality that iodine molecules enter the respiratory tract to kill pathogens. The small particle size iodine-containing aerosol can reach the alveoli and directly kill the pathogens in the alveoli, so that the critical and severe cases of pulmonary infection can be quickly out of danger, and mild cases can be cured quickly.

Cidi iodine lozenges are composed of a single iodine molecule. Dissolve two tablets in 20ml of sterile water to prepare a 0.015% solution, and inhale into the respiratory tract three times a day. It has been used in the treatment of common cold, influenza A, influenza B, bronchial Inflammation, pneumonia, etc., the effect is rapid.

The clinical treatment of 162 patients was summarized, as follows:

Basic conditions: aged 6-78 years, 106 males and 56 females, disease duration: 1-5 days, and none of them had underlying respiratory diseases.

Symptoms: fever, cough, sore throat, shortness of breath, etc.

Treatment method: stop other drugs, give 0.015% iodine solution atomization inhalation, 20ml each time, 3 times a day. Pneumonia patients were inhaled with glycerol-iodine solution, 20 large mouthfuls each time, three times a day.

Efficacy evaluation: All the above-mentioned symptoms disappeared or were significantly relieved on the first day of treatment in all cases, the pneumonia was cured in 5 days, and the other cases were cured in 1-3 days.

Analysis of Treatment of 162 Cases of Respiratory Infectious Diseases

	总人数total people	发热fever	咳嗽cough	咽喉疼痛sore throat	气急shortness of breath	缓解天数Remission days	痊愈天数recovery days
感冒cold	5353	3838	2828	2828	00	11	1-21-2
咽喉炎sore throat	22twenty two	55	1818	22twenty two	00	11	1-21-2
支气管炎bronchitis	5454	3232	5454	3030	00	11	1-21-2
肺炎pneumonia	66	66	66	33	33	1-31-3	4-54-5
甲流A stream	1515	1515	1111	1515	11	1-21-2	2-42-4
乙流B stream	1212	1212	88	1111	00	1-21-2	2-32-3

Note: It can be seen from the table that the curative effect is very ideal, and the patient recovers quickly.

To sum up, iodine can effectively kill various pathogens. It was mainly used in the sterilization of skin and oral mucosa in the human body. The present invention prepares iodine into a low-concentration atomizer, which is atomized into aerosol for inhalation, which can not only ensure the effective killing of pathogenic microorganisms, but also minimize the irritation to the respiratory mucosa, making the application of iodine in the treatment of respiratory infectious diseases a reality. . At present, there is a lack of effective drugs for respiratory viral infections in the world, and the prepared low-concentration iodine aerosol can easily kill various viruses after inhalation, and quickly control influenza A, influenza B, avian influenza, and new crowns. Severe infectious diseases such as pneumonia. Especially for new coronary pneumonia, low-concentration iodine solution and glycerol-iodine solution are used to atomize and inhale the alveoli, and active iodine vigorously kills the new coronavirus in the alveoli, so that mild cases can be quickly recovered, and severe and critical cases can be quickly removed from the danger of life, saving countless lives. Even if the new coronavirus mutates greatly in the future, or other respiratory infectious diseases appear, they can be used to solve the problem and avoid panic. Inhalation of iodine-containing aerosols also provides an efficient and simple treatment method for other pathogens such as common viruses and bacteria in the respiratory tract, and can also solve the problem of drug resistance. It is a subversive revolution in the treatment of respiratory infectious diseases. In the face of any respiratory infectious disease in the future, human beings can be calm, because they have mastered a powerful weapon to efficiently eliminate pathogens.

The prepared low-concentration iodine disinfectant is less irritating and safer.

The above-mentioned embodiments only represent two embodiments of the present invention, and the descriptions thereof are specific and detailed, but should not be construed as a limitation on the scope of the invention patent. It should be pointed out that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can also be made, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention should be subject to the appended claims.

Claims

The application of iodine in the preparation of medicaments for preventing and treating respiratory infectious diseases.
The application of iodine in the preparation of a medicine for preventing and treating respiratory infectious diseases according to claim 1, wherein the iodine is a simple substance or a molecule of iodine, and is applied in the preparation of a medicine for preventing and treating respiratory infectious diseases.
The application of iodine according to claim 1 or 2 in the preparation of a medicine for preventing and treating respiratory infectious diseases, it is characterized in that, the elemental iodine is directly dissolved in pure water to prepare an iodine solution for preventing and treating respiratory infectious diseases, as Nebulizer, inhaled into the respiratory tract through a nebulizer. The concentration of the iodine aqueous solution is not higher than the solubility of iodine in water, and the most suitable concentration of iodine is about 0.015%.
The application of iodine according to claim 1 and 2 in the preparation of a medicine for preventing and treating respiratory infectious diseases, it is characterized in that, the iodine element is mixed with oily solvent, and the iodine solution for preventing and treating respiratory infectious diseases is prepared as a mist. The nebulizer is inhaled into the respiratory tract through a nebulizer. The preparation ratio of the lipiodol solution is determined according to the specific situation, and it is most suitable to carry out according to the ratio of mixing about 20 mg of iodine element per 1 ml of oily solvent.
The application of iodine according to claim 1 or 2 in the preparation of a medicine for preventing and treating respiratory infectious diseases, it is characterized in that, an iodine-containing atomizer is prepared with iodine element, and the iodine-containing concentration of the atomizer is adjusted according to specific conditions It is used to treat severe respiratory infectious diseases such as new coronary pneumonia, influenza A, influenza B, and avian influenza.