CN113875782A - Externally applied spray for killing new coronavirus - Google Patents
Externally applied spray for killing new coronavirus Download PDFInfo
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- CN113875782A CN113875782A CN202111184334.5A CN202111184334A CN113875782A CN 113875782 A CN113875782 A CN 113875782A CN 202111184334 A CN202111184334 A CN 202111184334A CN 113875782 A CN113875782 A CN 113875782A
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- potassium
- kelp
- iodine
- exchange resin
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/03—Algae
Abstract
The invention relates to an external spray for killing new coronavirus, which comprises the following components: firstly preparing low-potassium kelp powder, and according to the cause of death caused by the new coronarism, the low-potassium kelp powder is prepared by the following steps: the other method is that iodine simple substance is extracted from cydiodine tablets or extracted from kelp laver and is prepared together with low-potassium kelp powder, turmeric and onion to prepare an external spray for killing the new crown virus, and according to the reference information report on 11 pages of < partial plant can inhibit the propagation of the new crown virus > at the technical frontier of 2021 year, 9 month and 29 days, turmeric extract curcumin obviously inhibits the propagation capacity of the new crown virus.
Description
Technical Field
The invention relates to the field of biological medicine, in particular to an external spray for killing new coronavirus.
Background
The novel coronavirus (Corona Virus Disease 2019) is an infectious Disease caused by the infection of a human body by the novel coronavirus (SARS-Cov-2), the symptoms of the coronavirus mainly comprise symptoms such as fever, cough, breathlessness, dyspnea and the like, and pneumonia, acute respiratory distress syndrome, renal failure and the like can be caused, and even death can be caused. Coronaviruses belong to the family coronaviridae in phylogenetic classification. The coronavirus is a positive strand single strand RNA virus with an outer mantle (envelope), the diameter of the coronavirus is about 80-120 nm, the genetic material of the coronavirus is the largest of all RNA viruses, and the coronavirus can only infect human, mouse, pig, cat, dog and poultry vertebrates generally.
The novel coronavirus enters a human body from a respiratory tract, the respiratory tract consists of a nasal cavity, a throat, a trachea, a bronchiole, a respiratory bronchiole, a alveolar duct and alveoli, and when the novel coronavirus breathes in, gas enters the alveoli from the nasal cavity to exchange gas and then is exhaled. From the nasal cavity to the alveolus, the pathogenic agent attacks the lung, causing rhinitis (common cold), pharyngolaryngitis, tracheobronchitis and pneumonia.
Although respiratory tract infection caused by bacteria, mycoplasma, chlamydia, fungi and the like can be resisted by antibiotics, the occurrence of drug-resistant bacteria is a difficult problem in modern medicine.
In view of the above, it is highly desirable to prepare a spray for external use which can kill pathogens causing respiratory tract infection with high efficiency, and kill new coronavirus more safely and rapidly.
Disclosure of Invention
The invention aims at the mutation Deltay of the current new coronavirus, C1.1.2 virus rampant, and discloses an external spray for killing the new coronavirus, which comprises the following components in part by weight: preparing low-potassium kelp powder, extracting iodine from cydiodine tablets, or extracting iodine from kelp or laver by using ion exchange resin, and combining with curcumin extracted from turmeric to prepare the external spray for killing the new coronavirus, wherein the new coronavirus in the environment is killed. The cause of death of people caused by the new coronary pneumonia is as follows: pulmonary fibrosis and hemagglutination death, the low-potassium kelp powder has the functions of softening blood vessels, preventing hemagglutination, supplementing potassium and discharging sodium, and the self-rescue of patients is achieved.
The invention has three technical characteristics:
firstly, the low-potassium kelp powder is adopted, potassium is supplemented and sodium is discharged, the principle is recognized by global medical scientists, when the low-potassium kelp powder is absorbed by a human body, the low-potassium kelp powder has the functions of supplementing potassium and discharging sodium, the maximum technical bright point of the low-potassium kelp powder has the function of softening blood vessels, preventing myocardial infarction and cerebral infarction, dredging blood vessel and preventing blood coagulation lumps, and removing impurities on blood vessel walls in main arteries, arterioles and capillaries of the human body, sodium attached to the blood vessel walls is subjected to displacement reaction and changed into low-molecular sodium alginate, the low-molecular sodium alginate is discharged from the body along with the blood major circulation and the urinary system, potassium elements enter the blood vessel walls and then disperse lumps, coagulates, thrombus, blood fat and other impurities in the blood coagulation, and the purposes of supplementing potassium and discharging sodium, softening blood vessels and regulating blood pressure are achieved along with the discharge of the sodium alginate.
Finally, the blood vessel of the lung is softened and endowed with elasticity, and the blood vessel is not agglomerated and hardened, so that the pulmonary fibrosis of the young state of the blood vessel is avoided, the lung of a patient can self-breathe, a breathing machine is not needed, and the self-rescue aim is achieved.
Therefore, the effect of the low molecular state potassium alginate on hypertension, diabetes, hyperlipidemia, hyperuricemia, coronary heart disease, cerebrovascular disease and the like can not only improve symptoms, but also can completely eliminate disease roots with high possibility and high price.
The preparation method of the low-potassium kelp powder comprises the following steps:
the method comprises the following steps: after the kelp is cleaned, cellulase with the amount of 0.5 percent of the dry kelp is added to promote the enzymolysis of partial cell walls of the kelp into glucose micromolecules so as to improve the extraction rate of alginic acid.
Step two: adding Na with the mass fraction of 3 percent after the kelp is subjected to enzymolysis2CO3The solution is digested at 50 ℃ for 3 h; adding alkali solution to convert calcium alginate into soluble sodium alginate, adding hydrochloric acid, converting calcium alginate into alginic acid under the action of hydrochloric acid, adding edible potassium chloride into alginic acid at a ratio of potassium chloride to alginic acid of 0.1:300, and filtering to remove residue to obtain potassium alginate.
Step three: adding alginate lyase into potassium alginate for degradation to obtain filtrate, wherein the optimal enzymolysis reaction conditions are that the pH is 5.0, the temperature is 45 ℃, the reaction time is 18h, and the enzyme adding amount is 100U/g.
Step four: ultrafiltering the filtrate by membrane separation technology, adding anhydrous ethanol to precipitate flocculent potassium alginate, and drying to obtain micromolecular potassium alginate, i.e. low-potassium kelp powder.
Secondly, the iodine has strong sterilization and special functions of adsorption, oxidation, virus resistance, DNA interaction and the like. However, since iodine is easily sublimed, it is common to compound iodine with various substrates to improve its stability, and conventional iodine compounds such as iodophors, iodine tincture, iodine anid, and cydiodine tablets, etc. Wherein the iodine tincture: can be used for treating skin infection and disinfection. Iodine glycerin: can be used for treating oral ulcer, gingivitis, and pericoronitis. Cydiodine tablet for treating chronic pharyngolaryngitis, oral ulcer, chronic gingivitis and periodontitis.
Iodine is a strong oxidant, can halogenate proteins of pathogenic microorganisms such as viruses, bacteria, fungi and the like, destroys active groups of protoplasm proteins of the viruses, the bacteria, the fungi and the like, is combined with amino acid of the proteins to denature the proteins so as to lose activity, and has strong killing effect. Moreover, iodine has very strong penetrating power to virus, bacteria and the like, and has quick action. It is surprising that iodine is used to kill respiratory infectious viruses, including new corona viruses.
Iodine is iodine simple substance or molecule, and the iodine simple substance or molecule is dissolved in water to prepare low-concentration iodine solution.
The preparation method of the iodine simple substance comprises the following steps:
the method comprises the following steps: selecting dried seaweed plants, washing the seaweed plants, placing the washed seaweed plants in a high-pressure container, carrying out heating treatment, placing the seaweed plants in iodine-free water for leaching after the heating treatment, and keeping the iodine-free water at a constant temperature.
Step two: and (3) performing primary filtration to obtain a tawny filtrate, sequentially passing the filtrate through middle control fiber ultrafilters of different specifications to remove substances such as macromolecular protein, polysaccharide and the like, and performing vacuum concentration by using a rotary evaporator to obtain a concentrated solution.
Step three: respectively passing the concentrated solution through anion exchange resin and cation exchange resin, adjusting the pH value of the concentrated solution passing through the anion exchange resin, and collecting the effluent passing through the anion exchange resin; adjusting the pH value of the concentrated solution passing through the cation exchange resin, collecting the effluent passing through the cation exchange resin, respectively eluting the anion exchange resin and the cation exchange resin, and collecting the eluent.
Step four: and (4) iodolysis: firstly, sulfuric acid is dropped into the eluent to acidify the eluent, and then NaNO is dropped into the eluent2The solution, the eluent has brownish black precipitate.
Step five: centrifugal separation and refining: and (3) standing and clarifying the solution obtained in the fourth step, sucking out the supernatant, transferring the residual solution and the brownish black precipitate into a centrifugal test tube for centrifugal separation, sucking out the supernatant in the centrifugal test tube after centrifugal separation to obtain crude iodine, adding the crude iodine into concentrated sulfuric acid for melting, and cooling and crystallizing to obtain the pure iodine simple substance.
Further, the seaweed plant is one or more of kelp, laver and seaweed.
Further, the high-pressure container is a pressure cooker, and the pressure is one standard atmospheric pressure, namely 0.1 MPa.
Further, the heating temperature of the heating treatment was 120 ℃ and the heating time was 30 minutes.
Further, the leaching time was 12 hours.
Further, the constant temperature of the constant temperature is 49-51 ℃.
Further, the hollow fiber ultrafilter had a pass molecular weight of 80000, 30000, 10000, and 3000, respectively.
Further, the rotary evaporator was operated at 80 ℃ and vacuum concentration was carried out at a normal atmospheric pressure.
Further, the pH value of the concentrated solution passing through the anion exchange resin is 3-4, and the pH value of the concentrated solution passing through the cation exchange resin is 9-10.
Further, 6 ml of sulfuric acid was added dropwise, and the concentration of the NaNO2 solution was 10% added dropwise.
Thirdly, crushing turmeric into coarse powder, respectively taking 15 times of water, 70% ethanol, 80% ethanol and 90% ethanol as extraction solvents, heating and refluxing for 2 hours, and filtering; and then, heating and refluxing the mixture by taking water as an extraction solvent twice, wherein 2 hours are respectively carried out, 10 times of the amount of the mixture is added for the first time, 8 times of the mixture is added for the second time, the mixture is filtered, the three filtrates are combined, the filtrate is decompressed and concentrated at 50 ℃ until an extract with the relative density of 1.10-1.20 (room temperature) is obtained, and the turmeric extract is obtained after vacuum drying at the temperature below 50 ℃.
The invention has the beneficial effects that: can prevent and treat new coronavirus, is an ideal biological medical product, can be used in medical health systems, families and social public places, and benefits all mankind.
Drawings
FIG. 1 is a flow chart of the preparation method of the low-potassium kelp powder of the invention;
FIG. 2 is a flow chart of the method for preparing elemental iodine according to the present invention;
FIG. 3 is a molecular formula of the low-potassium kelp powder of the present invention;
fig. 4 is a flow chart of the preparation method of curcumin of the present invention.
Detailed Description
So that the manner in which the objects, features and advantages of the present invention are attained and can be understood in detail, a more particular description of the invention, briefly summarized above, may be had by reference to the appended drawings. The present invention will be described below with reference to specific examples, but the present invention is not limited thereto.
According to the reference information report of 9/29/2021, the turmeric extract curcumin remarkably inhibits the reproductive capacity of new coronavirus at 11 pages of section plant capable of inhibiting the reproduction of new coronavirus at the scientific leading edge.
[ Eiffel, Spanish, Valencia, 9 months, 26 days ] title: turmeric and mustard help inhibit the ability of new coronavirus to multiply.
A study conducted at the university of valencia, showed that the natural extracts of turmeric and mustard significantly inhibited the ability of the new coronavirus to multiply.
The research aims at the potential of various natural extracts for inhibiting the reproductive capacity of the virus, and the research determines that 17 plant products are expected to be inhibitors for inhibiting the activity of 3CLPro protease of the novel coronavirus.
Researchers at this university have shown that the results of this study are an initial assessment of the potential active compounds in various plant extracts to inhibit or block protease activity. They analyzed the potential of using various plant extracts and/or natural compounds as inhibitors of the activity of novel coronavirus proteases.
Researchers have shown that kara-Jiharo genetically encode a protease called 3CLPro, which is critical in the generation of new viruses, in the new coronavirus itself.
She supplements saying: "in view of its importance, this protease has been chosen in different studies as a target for the search for potential inhibitors (natural or synthetic) which can reduce their activity and thus the virus' ability to multiply".
In this study, the research team established that a total of 17 plant products present in modern and traditional gourmet "are expected to be inhibitors of the activity of the novel coronavirus 3CLPro protease".
Their results were based on studies previously published by other groups and computer modeling, which validated the potential ability of various molecules to inhibit proteases.
Jiharro indicates that: based on this information, we selected vegetable foods enriched with these previously identified molecules with inhibitory effect and evaluated the extracts obtained from them.
As a result, extracts of Curcuma longa, mustard and a wild crucifer were most effective in inhibiting proteases at the concentrations evaluated. Among them, turmeric extract produced the best effect.
Jiharlo representation: "previously, other studies have predicted the affinity of various compounds contained in turmeric (referred to as curcumin) for 3CLPro, i.e., their potential to be used as such protease inhibitors, by computer modeling.
The investigators evaluated the extract obtained from turmeric rhizomes, "and obtained a positive in vitro result with inhibited activity for the first time.
The Giharo explanation: "furthermore, we also obtained positive results when testing commercial products after curcumin purification. Thus, the results of this study are consistent with those presented by the computer model ".
The research team emphasized that this research opened the way for future research.
Giharo's summary says: "the results of this study are a preliminary assessment of the potential of various plant extracts and/or natural compounds therein as inhibitors of the activity of novel coronavirus proteases".
The embodiment of the invention relates to an external spray for killing new coronavirus, which aims at the mutation delta of the current new coronavirus, C1.1.2 virus rampant, and comprises the following components: preparing low-potassium kelp powder, extracting iodine from cydiodine tablets, or extracting iodine from kelp or laver by using ion exchange resin, and combining with curcumin extracted from turmeric to prepare the external spray for killing the new coronavirus, wherein the new coronavirus in the environment is killed.
The cause of death of people caused by the new coronary pneumonia is as follows: pulmonary fibrosis and hemagglutination death, the low-potassium kelp powder has the functions of softening blood vessels, preventing hemagglutination, supplementing potassium and discharging sodium, and the self-rescue of patients is achieved.
At present, a coronavirus universal vaccine is being developed, which is reported in website [ british "daily news bulletin" 8 month and 18 days ] subject: pioneering research may push out "ideal" vaccines to prevent future epidemics, and "several companies" are already in the "contract phase" of developing vaccines.
Researchers recruited 8 SARS convalescent, 10 healthy people and 10 new coronary pneumonia convalescent, and compared the immune response of the three groups of people before and after vaccination with the existing new coronary vaccine.
Researchers especially want to understand whether antibodies elicited in SARS survivors can eliminate SARS virus, new corona virus, and other Sarbecovirus (subgenus to which new corona virus belongs), including viruses that may be transmitted by animals.
Before vaccination, detectable neutralizing antibodies against SARS virus were present in SARS survivors, but no or only low levels of neutralizing antibodies against the new coronavirus.
After two doses of the pfeira mRNA vaccine, all showed high levels of neutralizing antibodies that were able to cope with the new coronaviruses as well as the SARS virus. Most importantly, only SARS survivors have extensive neutralizing antibodies present and can cope with 10 Sarbecovirus viruses that were selected for testing.
One of the authors of the research reports, the national center for infectious diseases in singapore, responsible for professor david rieger, provides a strategy for dealing with the immune evasion exhibited by emerging viral variants against first-generation vaccines.
Covid-19 is a bacterium that is exposed to radiation only. Care should be taken only in people with low immunity. This radiation also causes inflammation and hypoxia. The patient should take aspirin-100 mg and aprenix or acetaminophen 650 mg.
In view of the above description, no real radical cure method is found for the new coronavirus variation occurring in and out of the sea at present, and the invention has three technical characteristics:
firstly, adopting low-potassium kelp powder, supplementing potassium and discharging sodium, which is a principle recognized by global medical scientists, when low-molecular-state potassium alginate is absorbed by a human body, the low-molecular-state potassium alginate has the functions of supplementing potassium and discharging sodium, the maximum technical bright point of the low-molecular-state potassium alginate has the function of softening blood vessels, preventing myocardial infarction and cerebral infarction, dredging blood coagulation lumps, and removing impurities on blood vessel walls in main arteries, arterioles and capillaries of the human body, wherein sodium attached to the blood vessel walls is subjected to replacement reaction to become low-molecular-state sodium alginate which is discharged from the body along with the blood circulation and the urinary system, and potassium element enters the blood vessel walls to disperse lumps, thrombus, blood fat and other impurities in the blood coagulation, so as to achieve the purposes of supplementing potassium and discharging sodium, softening blood vessels and regulating blood pressure along with the discharge of the sodium alginate.
Finally, the blood vessel of the lung is softened and endowed with elasticity, and the blood vessel is not agglomerated and hardened, so that the pulmonary fibrosis of the young state of the blood vessel is avoided, the lung of a patient can self-breathe, a breathing machine is not needed, and the self-rescue aim is achieved.
Vitamin K is published in the website of Wei newspaper of England 6.5.month to resist new crown pneumonia, and can prevent respiratory distress and death caused by pulmonary fibrosis! Advocated Life conservation from the K-containing food cheese broccoli, Meibo, etc. through dietary impedance pulmonary fibers! The disease-treating theory is that K element can soften blood vessels in lung! The low-potassium kelp powder contains a large amount of K element, so that the sodium salt block attached to the capillary vessel wall in the lung can be separated by a replacement reaction and becomes sodium alginate which is discharged out of the body along with the blood flow of thrombus, the blood coagulation block is prevented, the K element is dissolved in the capillary vessel to make the capillary vessel soft and elastic and become vitality in a young state, the lung can gradually breathe in a self-control manner, the generation of pulmonary fibrosis and blood coagulation can not occur, the impedance of new coronary pneumonia can seriously occur, and after the kelp powder is used by normal people, the aim of preventing diseases can be fulfilled.
Sodium is one of the vital elements, is mainly present in extracellular fluid, and can maintain water balance in vivo and muscle excitability. The daily intake of sodium is preferably 1100-3300 mg. Most of the sodium in the diet is in the form of sodium chloride, which is the main component of common salt. In addition to sodium in common salt, sodium is present in almost all foods in varying amounts.
Excessive intake of sodium salts is a significant cause of the development of hypertension. When the concentration in the blood vessel is too high, part of sodium ions can adhere to the inner wall of the blood vessel along with other substances such as cholesterol and the like and gradually permeate into the blood vessel wall, so that on one hand, the blood vessel loses elasticity and becomes stiff, the blood pressure is increased, and finally, the cerebral vessels are ruptured and bleed; on the other hand, thrombus is formed on the basis of angiosclerosis, so that heart and cerebral embolism are caused, and coronary heart disease and cerebral infarction are formed.
The world health organization advocates: the daily intake of sodium salt should be controlled within 5-6 g, but the residents in China often exceed standards. The human body absorbs potassium ions, potassium and sodium are subjected to ion exchange, and the sodium ions are discharged out of the body, so that the concentration of the sodium ions in blood vessels is reduced, the blood pressure rise and the angiosclerosis are prevented, and the occurrence of hypertension and cardiovascular and cerebrovascular diseases is avoided. Potassium can also activate cardiac muscle function, and can effectively recover and strengthen the self-regulation function of human body to blood pressure.
The low potassium kelp powder improves microcirculation, which is related to the improvement of vegetative nerve function, because it changes the regulating function of nerve to microvasculature and solves the microcirculation disturbance. Modern medicine considers that: the development of hypertension, diabetes, hyperlipidemia, hyperuricemia are closely related to microcirculation disturbance. The disease roots of the above diseases can be removed as long as the microcirculation disturbance is completely removed, and the low-potassium kelp powder has the effect.
Therefore, the low-potassium kelp powder has the effects of improving symptoms and completely eliminating disease roots, and is more difficult and expensive to act on hypertension, diabetes, hyperlipidemia, hyperuricemia, coronary heart disease, cerebrovascular disease and the like.
Potassium supplement and sodium discharge: natural potassium is known as a long life factor for reducing hypertension and cardiovascular and cerebrovascular diseases of old people, and high-potassium low-sodium diet can obviously reduce the risk of hypertension and apoplexy of patients. The incidence of cardiovascular and cerebrovascular diseases and hypertension of local people in the Russian Gaogansu area, which is one of the five famous longevity countries in the world, is far lower than that of other areas in the world, and the root cause of the disease is that the local people are interested in eating the food pickled by sylvite with very high potassium content through expert investigation, so that the incidence of the hypertension and the cardiovascular and cerebrovascular diseases is greatly reduced, and the local people have long lives due to the fact that the latest scientific research shows that: natural high-quality potassium can inhibit sodium absorption and expel sodium ions in blood out of the body, so that the blood pressure of a human body is obviously reduced, the stroke probability of hypertension is greatly reduced, the potassium can soften and protect blood vessels, the arterial wall can be prevented from thickening, the phenomena of blood coagulation and the like can be prevented, cerebral blood in the brain of the human body is regulated, the cardiac muscle function is activated, the self-regulation function of the human body on the blood pressure is effectively recovered and strengthened, and therefore, potassium supplement and sodium discharge are advocated by the medical community as the most scientific, safe and efficient blood pressure reduction mode at present.
Maintenance of blood vessels, in particular prevention of stroke: the disease of cerebral apoplexy is caused by cerebrovascular occlusion and cerebrovascular rupture, while the low-potassium kelp powder can permeate into cerebral capillaries to remove free radicals, sodium ions and thrombus residues attached to the vessel wall in the cerebral vessels. The thrombus and blood clots are removed, and the residues enter the blood circulation of the aorta and are discharged outside the body. The kelp powder with low potassium has the functions of softening blood vessel, making blood vessel elastic, and preventing hard lump and rupture. The low-potassium kelp powder inhibits the concentration rise of free calcium ions in vascular smooth muscle cytoplasm by cleaning cholesterol impurities attached to the vascular wall, thereby preventing the synthesis of vascular smooth muscle DNA and protein and the thickening of the vascular wall, softening the blood vessel, discharging residues and blood clots in the blood vessel out of the body along with circulation and keeping the blood vessel of a human body in a young state.
Purifying blood: a large number of clinical trials prove that the low-potassium kelp powder can effectively reduce blood fat and blood sugar. The blood fat reducing effect is achieved by adsorbing cholesterol and triglyceride in blood flow through the low molecular state potassium alginate and discharging the cholesterol and triglyceride out of the body, the blood sugar reducing effect is that the low potassium kelp powder can compete with sugar more easily to a binding site of a-glycosidase, and when the site is occupied by the low molecular state potassium alginate, the blood sugar of a human body is adjusted to a normal level. In addition, the low molecular state potassium alginate with negative charges can break red blood pellets in blood, thereby obviously reducing blood viscosity blood clots of patients and preventing the formation of thrombus, and the low potassium kelp powder fundamentally purifies the blood environment of human bodies in various aspects.
And (3) cycle improvement: the low potassium kelp powder can improve the deformability of erythrocyte, increase oxygen and nutrient components in blood, and improve microcirculation.
The method replaces western medicines: the low-potassium kelp powder can be clinically shown to have the effect of inhibiting ACE vasodilatation similar to natural angiotensin converting enzyme, can reduce the level of aldehyde ketone in blood plasma, increase renal blood flow and reduce sodium retention, so that the low-potassium kelp powder has a very obvious blood pressure reducing effect through clinical verification, and indexes can be quantized and compared with any existing hypertension medicine.
Loosening bowel to relieve constipation: the low-potassium kelp powder contains hydroxyl fiber compounds, has the functions of wrapping water in intestinal tracts of human bodies and relaxing bowel, and accordingly solves the problem that old hypertension patients have constipation or cardiovascular and cerebrovascular accidents caused by the constipation.
And the pH value of the low-potassium kelp powder belongs to alkalescent medicines, so that the body constitution of a patient is alkaline after the patient eats the kelp powder for a long time, and the immunity is improved.
Through human body tests, the blood pressure of a tester at the moment is 180/110, the tester drops to 110/70 after eating the low-potassium kelp powder for one month, because the tester is older and uncomfortable, the blood pressure of the tester cannot drop too low, the tester is called to stop taking the kelp powder, the blood pressure of the tester rebounds to 130/90 after the test is ended for one month, the tester feels comfortable and normal to the tester, the tester trusts the curative effect of reducing the blood pressure, the tester cuts fingers in a kitchen to cut vegetables and before taking the low-potassium kelp powder, the blood viscosity is sticky, the blood viscosity tends to be normal after taking the kelp powder, the hemagglutination phenomenon can be prevented, in addition, a researcher who talks about Liu mr who is in the middle school, the body can bear any burden to carry out scientific research to obtain the cardiovascular and cerebrovascular diseases, the heart bridges, and the friend prepares the medicines for three months later, after one month, the blood pressure of the patient is obviously reduced, the pace-beating of the heart is normal, the patient uses the prepared medicine to treat the mother, the mother is a 90-month old person, the hypertension of the family history of the mother is reduced after the patient eats the medicine for one month, the patient is very cherished, and the patient does a blood type check to find that the blood pressure and the potassium elements of the patient are normal and can not cause the hypertension, so that the low-potassium kelp powder is very safe to the human body and can not cause the hyperkalemia!
The inventor of Liu Gong assist in the study of the fact that low molecular state potassium alginate has obvious curative effect requirements and continues to take the medicine, seriously declares that the kidney function and the heart and lung of the patient before taking the medicine are normal and the patient does not have hyperkalemia.
The potassium [ K + ] test result is 4.7mmol/L, and the reference value is 3.50mmol/L-5.50 mmol/L.
The method for researching the influence of the low-potassium kelp powder on the blood pressure of Spontaneous Hypertensive Rats (SHRs) and the pharmacokinetic law in mice adopts a tail pulse indirect pressure measurement method to measure the systolic pressure of the SHRs, and 40 rats are randomly divided into 5 groups: a blank solvent control group, a hydrochlorothiazide tablet group (6.25mg/kg), a low molecular state potassium alginate high dose, medium dose and low dose group (500, 250 and 100mg/kg), and the administration is performed by intragastric administration every day for 28 days continuously; measuring blood pressure every week, observing blood pressure changes of 3d and 6d after drug withdrawal, irrigating KM mice with 100mg/kg (74MBq/kg) of low-potassium kelp powder for 3 days, taking blood from tail parts of 2, 5, 10, 20, 30min and 1, 2, 4, 6, 12, 24, 48, 72, 96, 120 and 144h after drug administration, measuring sample radioactivity, fitting pharmacokinetic parameters of the low-potassium kelp powder orally administered in the mice by DAS2.0 software, and comparing the results with a solvent control group at the same period, the blood pressure levels of SHRs of 3 dose groups continuously administered with 21d and 28d, hydrochlorothiazide and low-potassium kelp powder are averagely reduced (P is less than 0.01); when stopping taking the medicines for 3d and 6d, the pressure reducing effect of 6.25mg/kg hydrochlorothiazide disappears (P is more than 0.05); when stopping for 3d, the systolic blood pressure of the high, medium and low 3 dosage groups of the low molecular state potassium alginate is averagely lower than that of the synchronous solvent control group (P <0.05 or P < 0.01); when the medicine is stopped for 6 days, 250 and 500mg/kg of low-potassium kelp powder can still reduce the blood pressure level (P is less than 0.01) of SHRs, the pharmacokinetics law of the low-potassium kelp powder in a mouse body after gastric lavage meets a biventricular model, the half-life period of an absorption phase is 2.76h, the half-life period of a distribution phase is 42.30h, the half-life period of an elimination phase is 42.31h, and the half-life period in the body is 36.28 h.
And (4) conclusion: continuous oral administration of low-potassium kelp powder can reduce SHRs blood pressure dose-dependently, and withdrawal of 6d still shows sustained blood pressure reducing effect, which may be related to slow in vivo elimination of low-potassium kelp powder after oral administration.
The preparation method of the low-potassium kelp powder comprises the following steps:
the method comprises the following steps: after the kelp is cleaned, cellulase with the amount of 0.5 percent of the dry kelp is added to promote the enzymolysis of partial cell walls of the kelp into glucose micromolecules so as to improve the extraction rate of alginic acid.
Step two: after kelp is subjected to enzymolysis, adding a Na2CO3 solution with the mass fraction of 3%, wherein the temperature is 50 ℃, and the digestion time is 3 hours; adding alkali solution to convert calcium alginate into soluble sodium alginate, adding hydrochloric acid, converting calcium alginate into alginic acid under the action of hydrochloric acid, adding edible potassium chloride into alginic acid at a ratio of potassium chloride to alginic acid of 0.1:300, and filtering to remove residue to obtain potassium alginate.
Step three: adding alginate lyase into potassium alginate for degradation to obtain filtrate, wherein the optimal enzymolysis reaction conditions are that the pH is 5.0, the temperature is 45 ℃, the reaction time is 18h, and the enzyme adding amount is 100U/g.
Step four: ultrafiltering the filtrate by membrane separation technology, adding anhydrous ethanol to precipitate flocculent potassium alginate, and drying to obtain micromolecular potassium alginate, i.e. low-potassium kelp powder.
Secondly, the iodine has strong sterilization and special functions of adsorption, oxidation, virus resistance, DNA interaction and the like. However, since iodine is easily sublimed, it is common to compound iodine with various substrates to improve its stability, and conventional iodine compounds such as iodophors, iodine tincture, iodine anid, and cydiodine tablets, etc. Wherein the iodine tincture: can be used for treating skin infection and disinfection. Iodine glycerin: can be used for treating oral ulcer, gingivitis, and pericoronitis. Cydiodine tablet for treating chronic pharyngolaryngitis, oral ulcer, chronic gingivitis and periodontitis.
Iodine is a strong oxidant, can halogenate proteins of pathogenic microorganisms such as viruses, bacteria, fungi and the like, destroys active groups of protoplasm proteins of the viruses, the bacteria, the fungi and the like, is combined with amino acid of the proteins to denature the proteins so as to lose activity, and has strong killing effect. Moreover, iodine has very strong penetrating power to virus, bacteria and the like, and has quick action. It is surprising that iodine is used to kill respiratory infectious viruses, including new corona viruses.
Iodine is iodine simple substance or molecule, and the iodine simple substance or molecule is dissolved in water to prepare low-concentration iodine solution.
The preparation method of the iodine simple substance comprises the following steps:
the method comprises the following steps: selecting dried herba Zosterae Marinae, washing, and treating in pressure cooker at 120 deg.C under 0.1MPa for 30 min. Then leaching the mixture in 10 times of iodine-free water for 12 hours, and keeping the temperature at about 50 ℃. Filtering to obtain a yellow brown filtrate.
Step two: the filtrate was passed through a hollow fiber ultrafilter having molecular weights of 80000, 30000, l0000, and 3000 in order to remove macromolecular proteins, polysaccharides, and the like. Then concentrated in vacuo using a rotary evaporator at 80 degrees, 0.1 MaP.
Step three: enabling the concentrated solution to pass through anion exchange resin and cation exchange resin, adjusting the pH of the concentrated solution to 3-4, enabling the concentrated solution to pass through the anion exchange resin, and collecting effluent liquid; adjusting the pH value of the effluent to 9-10, passing through a cation exchange column, and collecting the effluent (the effluent contains organic iodine).
Eluting with anion and cation exchange resin, and collecting eluate (containing inorganic iodine).
Step four: iodizing by adding 6M sulfuric acid dropwise into the eluate, adding 10% NaNO2 solution dropwise, and precipitating with brown black precipitate.
Step five: centrifugal separation and refining: standing the crude iodine solution for clarification, carefully sucking out the supernatant, transferring the residual solution and crude iodine into a centrifugal test tube for centrifugal separation, and sucking out the supernatant to obtain crude iodine. Adding the crude iodine into concentrated sulfuric acid for melting, cooling and crystallizing to obtain pure iodine simple substance.
The detection method comprises the following steps:
(1) sample treatment
Sample 2g (accurate to 0.1mg) is weighed into 500g of iodine-free salt and stirred well. Subpackaging into 50g bags for inspection.
(2) For submission
Detecting total iodine according to national standard GB 5009.267-2016; detecting potassium iodate according to the national standard GB5009.42-2016 (common salt detection method).
(3) Detection of iodine simple substance and potassium iodide
Weighing 10.0g of the sample to be detected, adding 40mL of iodine-free water, capping a triangular flask, shaking the flask at 50 ℃ for 60min, and filtering to obtain a constant volume of 50mL for later use.
Taking 5mL of the sample, adding 4 drops of sulfuric acid (1+3), and judging the existence form of iodine in the solution:
1. the method for judging the existence of the iodine simple substance comprises the following steps: 1 drop of 0.5% starch solution was added directly without turning blue. Indicating that no iodine exists in the solution.
2. The method for judging the existence of the iodide ions comprises the following steps: adding 1 drop of 0.5% starch solution, and then adding 0.5mol/L FeCl dropwise3The solution did not turn blue all the time during the dropping process. Indicating that no potassium iodide was present in the solution.
(4) Judgment of samples to be examined
If potassium iodate is not present in quantitative detection, iodine simple substance (I) is not present in qualitative analysis detection2) And no potassium iodide exists, so that the quality of the sample to be detected can be judged to be qualified.
If potassium iodate is present in quantitative detection, elemental iodine (I) is present in qualitative analysis detection2) And with potassium iodideIf any of the three items exists, the sample to be tested is unqualified.
(5) Calculation of the content of organic iodine
As in the above detection, no iodine element (I)2) Iodine ion (I-) and Iodate (IO)3-) So the organic iodine is indirectly measured by referring to the international common subtraction method:
organic iodine (total iodine) -inorganic iodine
Thirdly, crushing turmeric into coarse powder, respectively taking 15 times of water, 70% ethanol, 80% ethanol and 90% ethanol as extraction solvents, heating and refluxing for 2 hours, and filtering; and then, heating and refluxing the mixture by taking water as an extraction solvent twice, wherein 2 hours are respectively carried out, 10 times of the amount of the mixture is added for the first time, 8 times of the mixture is added for the second time, the mixture is filtered, the three filtrates are combined, the filtrate is decompressed and concentrated at 50 ℃ until an extract with the relative density of 1.10-1.20 (room temperature) is obtained, and the turmeric extract is obtained after vacuum drying at the temperature below 50 ℃.
Claims (4)
1. An external spray for killing new coronavirus is prepared from low-potassium kelp powder, iodine extracted from cydiodine tablet, or iodine extracted from kelp or laver by ion exchange resin, and curcumin extracted from curcuma longa through mixing.
2. The externally applied spray for killing new coronavirus according to claim 1, wherein the preparation method of the low-potassium kelp powder comprises the following steps:
the method comprises the following steps: after the kelp is cleaned, cellulase with the amount of 0.5 percent of the dry kelp is added to promote the enzymolysis of partial cell walls of the kelp into glucose micromolecules so as to improve the extraction rate of alginic acid.
Step two: adding Na with the mass fraction of 3 percent after the kelp is subjected to enzymolysis2CO3The solution is digested at 50 ℃ for 3 h; then adding alkali liquor to convert calcium alginate into soluble sodium alginate, adding hydrochloric acid, converting the calcium alginate into alginic acid under the action of the hydrochloric acid, and adding edible potassium chloride into the alginic acidAnd the ratio of the potassium chloride to the alginic acid is 0.1:300, and then filtering and removing residues to obtain the potassium alginate.
Step three: adding alginate lyase into the potassium alginate for degradation to obtain a filtrate, wherein the optimal enzymolysis reaction conditions are that the pH is 5.0, the temperature is 45 ℃, the reaction time is 18h, and the enzyme adding amount is 100U/g.
Step four: and ultrafiltering the filtrate by adopting a membrane separation nano technology, adding absolute ethyl alcohol to separate out flocculent potassium alginate, and drying to obtain micromolecule potassium alginate, namely the low-potassium kelp powder.
3. The external spray for killing the new coronavirus as claimed in claim 1, wherein the preparation method of the elementary iodine comprises the following steps:
the method comprises the following steps: selecting dried kelp, laver or seaweed, washing the kelp, laver or seaweed, placing the washed kelp, laver or seaweed in a pressure cooker, heating the kelp, laver or seaweed at 120 ℃ for 30 minutes, leaching the kelp, laver or seaweed in iodine-free water after the heating treatment, wherein the leaching time is 12 hours, and keeping the constant temperature of the iodine-free water at 49-51 ℃.
Step two: performing primary filtration to obtain a yellow brown filtrate, sequentially passing through medium control fiber ultrafilters with different specifications of molecular weights of 80000, 30000, 10000 and 3000 to remove macromolecular proteins, polysaccharides and other substances, and then using a rotary evaporator, wherein the working temperature of the rotary evaporator is 80 ℃, and performing vacuum concentration under a standard atmospheric pressure to obtain a concentrated solution.
Step three: respectively passing the concentrated solution through anion exchange resin and cation exchange resin, adjusting the pH value of the concentrated solution passing through the anion exchange resin, wherein the pH value of the concentrated solution passing through the anion exchange resin is 3-4, and collecting effluent liquid passing through the anion exchange resin; adjusting the pH value of the concentrated solution passing through the cation exchange resin to be 9-10, collecting effluent liquid passing through the cation exchange resin, respectively eluting the anion exchange resin and the cation exchange resin, and collecting eluent.
Step four: and (4) iodolysis: firstly, 6 ml of sulfuric acid is dripped into the eluent for acidification, and then 10 percent NaNO is dripped into the eluent2A solution in which a brownish black precipitate is present in the eluent.
Step five: centrifugal separation and refining: and C, standing and clarifying the solution obtained in the fourth step, sucking out the supernatant, transferring the residual solution and the brownish black precipitate into a centrifugal test tube for centrifugal separation, sucking out the supernatant in the centrifugal test tube after centrifugal separation to obtain crude iodine, adding the crude iodine into concentrated sulfuric acid for melting, and cooling and crystallizing to obtain the pure iodine simple substance.
4. The externally applied spray for killing the new coronavirus according to claim 1, wherein the curcumin is prepared by the following steps: pulverizing Curcuma rhizome into coarse powder, respectively extracting with 15 times of water, 70% ethanol, 80% ethanol, and 90% ethanol under reflux for 2 hr, and filtering; and then, heating and refluxing the mixture by taking water as an extraction solvent twice, wherein 2 hours are carried out each time, 10 times of the amount of the mixture is added for the first time, 8 times of the mixture is added for the second time, filtering is carried out, the three filtrates are combined, the filtrate is decompressed and concentrated at 50 ℃ until an extract with the relative density of 1.10-1.20 (room temperature) is obtained, and vacuum drying is carried out at the temperature below 50 ℃ to obtain the turmeric curcumin extract.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1597703A (en) * | 2004-08-20 | 2005-03-23 | 赵波 | Low molecular potassium alginate and its application |
| CN107149132A (en) * | 2017-04-29 | 2017-09-12 | 深圳震乾坤生物科技有限公司 | Low potassium Kelp Powder row's sodium salt and preparation method and application |
| CN112791097A (en) * | 2020-11-27 | 2021-05-14 | 金玉东 | Application of iodine in preparing medicament for preventing and treating respiratory infectious diseases and method for preparing low-particle-size iodine-containing aerosol |
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Patent Citations (3)
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|---|---|---|---|---|
| CN1597703A (en) * | 2004-08-20 | 2005-03-23 | 赵波 | Low molecular potassium alginate and its application |
| CN107149132A (en) * | 2017-04-29 | 2017-09-12 | 深圳震乾坤生物科技有限公司 | Low potassium Kelp Powder row's sodium salt and preparation method and application |
| CN112791097A (en) * | 2020-11-27 | 2021-05-14 | 金玉东 | Application of iodine in preparing medicament for preventing and treating respiratory infectious diseases and method for preparing low-particle-size iodine-containing aerosol |
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Application publication date: 20220104 |