WO2022110019A1

WO2022110019A1 - Aortic pressure waveform image generation method and storage medium

Info

Publication number: WO2022110019A1
Application number: PCT/CN2020/132273
Authority: WO
Inventors: 徐磊; 刘广志; 王之元; 王鹏
Original assignee: 苏州润迈德医疗科技有限公司
Priority date: 2020-11-26
Filing date: 2020-11-27
Publication date: 2022-06-02
Also published as: CN112494021A

Abstract

An aortic pressure waveform image generation method and a storage medium, comprising: obtaining data of an aortic pressure Pa (S100); extracting a smooth pressure waveform according to the aortic pressure Pa (S200); setting a display interval of the smooth pressure waveform (S300); setting a data range of the smooth pressure waveform (S400); and generating an aortic pressure waveform image according to the display interval, the data range, and the smooth pressure waveform (S500). According to the aortic pressure waveform image generation method, an aortic pressure waveform image can be quickly, accurately and automatically generated from original aortic pressure data on the basis of a heartbeat cycle and a pressure transmission rate.

Description

Aortic pressure waveform image generation method and storage medium

technical field

The invention relates to the technical field of coronary medicine, in particular to a method for generating aortic pressure waveform images and a storage medium.

Background technique

The deposition of lipids and carbohydrates in human blood on the blood vessel wall will form plaques on the blood vessel wall, which will then lead to vascular stenosis; especially the vascular stenosis near the coronary arteries of the heart will lead to insufficient blood supply to the heart muscle and induce coronary heart disease. , angina pectoris and other diseases pose a serious threat to human health. According to statistics, there are about 11 million coronary heart disease patients in my country, and the number of patients treated with cardiovascular interventional surgery is increasing by more than 10% every year.

Although conventional medical detection methods such as coronary angiography (CAG) and computed tomography (CT) can display the severity of coronary artery stenosis, they cannot accurately evaluate coronary ischemia. In order to improve the accuracy of coronary vascular function evaluation, in 1993, Pijls proposed a new index for calculating coronary vascular function through pressure measurement - Fractional Flow Reserve (FFR). After long-term basic and clinical research, FFR It has become the gold standard for functional evaluation of coronary stenosis.

Fractional flow reserve (FFR) usually refers to the fraction of myocardial blood flow reserve, which is set as the ratio of the maximum blood flow that the diseased coronary artery can provide to the myocardium to the maximum blood flow when the coronary artery is completely normal. In the state, the ratio of blood flow can be replaced by the pressure value. That is, the measurement of the FFR value can be calculated by measuring the pressure at the distal stenosis of the coronary artery and the pressure at the proximal end of the coronary stenosis through the pressure sensor under the state of maximum coronary hyperemia.

In the current physical examination of patients, the brachial artery pressure is generally recorded to reflect the real-time changes in blood pressure. During the calculation of fractional flow reserve (FFR), brachial artery pressure cannot meet the calculation accuracy, so more accurate parameters that are closer to cardiovascular pressure are required. In the present invention, the aortic pressure is used to participate in the calculation, and the aortic pressure waveform image is automatically analyzed and obtained according to the aortic pressure waveform, which can present the important information required for the calculation more comprehensively, and can also help the doctor to grasp the change of the aortic pressure more intuitively. .

SUMMARY OF THE INVENTION

The invention provides a method for generating aortic pressure waveform images and a storage medium, so as to solve the problems that the brachial artery pressure cannot meet the calculation accuracy and the aortic pressure waveform is not intuitive enough.

In order to achieve the above objects, in a first aspect, the present application provides a method for generating an aortic pressure waveform image, including:

Obtain aortic pressure _Pa data;

extracting _a stable pressure waveform according to the aortic pressure Pa;

setting the display interval of the stable pressure waveform;

setting the data range of the smooth pressure waveform;

The aortic pressure waveform image is generated according to the display interval, the data range and the smooth pressure waveform.

Optionally, the above-mentioned method for generating aortic pressure waveform images, the method for acquiring aortic pressure _Pa data, includes:

Obtain aortic inlet pressure with a disposable blood pressure sensor.

Optionally, in the above-mentioned method for generating an aortic pressure waveform image, the method for extracting _a stable pressure waveform according to the aortic pressure Pa includes:

Set multiple index lists and physiological parameter thresholds;

Calculate the average pressure according to the index list, the physiological parameter threshold, and the aortic pressure data;

Obtain a pressure mean point according to the mean pressure;

Divide the data period according to the pressure mean point, and obtain the pressure parameters in each heartbeat period;

According to the pressure parameters, a stable pressure waveform is obtained.

Optionally, in the above-mentioned method for generating aortic pressure waveform images, the multiple index lists include: a temporary storage list, a save list, a mean point index list, a maximum value point index list, and a minimum value point index list.

Optionally, in the above-mentioned method for generating aortic pressure waveform images, the physiological parameter thresholds include: the number of heartbeat cycles C, the range from diastolic blood pressure to systolic blood pressure, the minimum pressure amplitude threshold, the fluctuation difference of systolic blood pressure or diastolic blood pressure, and the range of heart rate. , the number of pressures N _threshold , the upper limit of the number of files, the cut-off pressure threshold P- _cut , the cut-off heart rate threshold HR _cut -off, and the pressure transmission rate threshold V- _threshold .

Optionally, in the above-mentioned method for generating an aortic pressure waveform image, the method for calculating the average pressure from the aortic pressure data according to the index list and the physiological parameter threshold includes:

Obtain a heartbeat cycle time threshold according to the heart rate threshold;

Acquire the range of the number of data points in a described heartbeat cycle according to a described heartbeat cycle quantity C and a pressure transmission rate threshold;

A time period is defined according to the range of the number of data points. After each time period ends, the number of all data points is counted, and all acquired aortic pressures and acquired times are stored in the temporary stored in the list;

If the number of data in the temporary storage list is an integer multiple of the N _threshold , and is greater than the minimum threshold of the range of the number of data points, and less than the maximum threshold of the range of the number of data points, calculate the aorta in all temporary storage lists The average value of the pressure is the average pressure.

Optionally, in the above-mentioned method for generating an aortic pressure waveform image, the method for calculating the average pressure from the aortic pressure data according to the index list and the physiological parameter threshold further includes:

If the _n consecutive aortic pressures Pa in the temporary storage list are all smaller than the _cut -off pressure threshold Pt, the _n aortic pressures Pa are removed from the temporary storage list.

Optionally, the above-mentioned method for generating an aortic pressure waveform image, the method for obtaining a pressure mean point according to the mean pressure includes:

set mean point index list;

adding pressure mean points to the mean point index list;

Generate a pressure mean point curve according to the pressure mean point;

filtering pressure mean points on the pressure mean point curve;

Determine whether the number of the pressure mean points in the mean point index list meets the heartbeat cycle requirement, if not, repeat claim 7, and adjust the size of n until the heartbeat cycle requirement is met.

Optionally, in the above-mentioned method for generating aortic pressure waveform images, the method for adding pressure mean points to the mean point index list includes:

Compare the aortic pressure _Pa in the temporary storage list with the average pressure

Compare;

if

and

Then add PK to the mean point index list, wherein PK and _PK+1 represent the _Kth and _K +1th aortic pressures in the temporary storage list, respectively;

if

and

Then add _PK to the list of mean point indices.

Optionally, in the above-mentioned method for generating an aortic pressure waveform image, the method for filtering the pressure mean point on the pressure mean point curve includes:

According to D _n =P _n+1 -P _n , where P _n and P _n+1 represent the nth and n+1th aortic pressures in the mean point index list, respectively, and the D _n represents P _{n+ 1.} The pressure difference of P _n ;

According to HR _n =30/(D _n /n), obtain the heart rate frequency value HR _n in the nth half heartbeat cycle;

If HR _n <HR _cutoff , delete the mean pressure point corresponding to the HR _n from the mean point index list;

if

And after P _n m consecutive aortic pressures are greater than

and

Then, m consecutive pressure mean points after P _n are deleted from the mean point index list.

Optionally, in the above-mentioned method for generating aortic pressure waveform images, the method of judging whether the number of the pressure mean points in the mean point index list meets the requirements of the heartbeat cycle, if not, repeat the above method, and adjust the value of n. Sizes until the heartbeat cycle requirement is met include:

If the number of data N in the _mean point list is less than 2C+1, the heartbeat cycle requirement is not met, and the above method is repeated;

Adjust the size of n until N _is ≥ 2C+1.

Optionally, in the above-mentioned method for generating aortic pressure waveform images, the method for dividing a data period according to the pressure mean value point to obtain pressure parameters in each heartbeat period includes:

if

Extract the maximum pressure P _max in the heartbeat cycle where P _n is located and the position S _max where the maximum pressure P _max is located from the temporary storage list, and add the S _max and P _max to the diastolic pressure list in one-to-one correspondence ;

Obtain the average value of _Pmax in the diastolic blood pressure list, and obtain the diastolic blood pressure _Pshu ;

if

Extract the minimum pressure P _min in the heartbeat cycle where P _n is located and the position S _min where the minimum pressure P _min is located from the temporary storage list, and add the S _min and P _min to the systolic blood pressure list in one-to-one correspondence ;

Obtain the average value of P _min in the systolic blood pressure list to obtain the systolic blood pressure P _close .

Optionally, in the above-mentioned method for generating aortic pressure waveform images, if _Pshu is not within the range of diastolic blood pressure to systolic blood pressure, the temporary storage list is re-acquired.

Optionally, in the above-mentioned method for generating an aortic pressure waveform image, the method for re-acquiring the temporary storage list if P is not within the range of _diastolic blood pressure to systolic blood pressure includes: converting the first half of the temporary storage list into Part of the data is intercepted into the save list, if the number of data is greater than the upper limit of the save list, the first half of the data in the temporary storage list using the save list is directly replaced into the temporary storage list, and the Save the list.

Optionally, the above-mentioned method for generating an aortic pressure waveform image, the method for obtaining a stable pressure waveform according to the pressure parameter, includes:

Set the offset to _Vthreshold /a, and intercept the start point O and end point E;

The average point index list, the diastolic pressure list, and the systolic pressure list are all executed according to the above offset, start point O, and end point E, and output the stable pressure waveform, diastolic pressure waveform, and systolic pressure waveform.

Optionally, the above-mentioned method for generating an aortic pressure waveform image further includes: obtaining the heart rate HR according to the stable pressure waveform and HR=60V _threshold /(N _average /C).

Optionally, in the above-mentioned method for generating an aortic pressure waveform image, the method for setting the display interval of the stable pressure waveform includes:

setting the length W ₁ and the width H ₁ of the generated aortic pressure waveform image;

setting the outer frame length W ₂ and width H ₂ of the aortic pressure waveform image;

According to W=W ₁ -2W ₂ and H=H ₁ -2H ₂ , the length W and the width H of the display interval of the steady pressure waveform are obtained.

Optionally, in the above-mentioned method for generating an aortic pressure waveform image, the method for setting the data range of the stable pressure waveform includes:

Set the X-axis duty cycle threshold of the stable pressure waveform, and the interpolation number between the two intersection points of the stable pressure waveform and the X-axis; set the sampling interval time; by adjusting the interpolation number and the sampling interval time, to obtain the data range of the X-axis where the X-axis duty cycle of the stable pressure waveform is greater than or equal to the X-axis duty cycle threshold; and/or

Set the Y-axis duty cycle threshold to r, and set the ratio of the data range to the display space to be a; then the Y-axis data length is L=(P _Shu -P _Close )+(P _Shu -P _Close ) /r; the minimum value of the Y-axis data ymin =P _close- ( _Pshu - _Pclose )/ar; _the maximum value of the Y-axis data _ymax = _Pshu +( _Pshu - _Pclose )/ar; The Y-axis data range of the stationary pressure is [y _min , y _max ].

Optionally, in the above-mentioned method for generating an aortic pressure waveform image, the method for generating an aortic pressure waveform image according to the display interval, data range and stable pressure waveform includes:

Create a new image space with length W and width H;

Set the background color or background picture of the picture space, and add a border;

Set the color of (x, y) pixels;

The X-axis display pixel range is [W ₂ ,W ₁ -1-W ₂ ], and the Y-axis display pixel range is [H ₂ ,H ₁ -1-H ₂ ];

An aortic pressure waveform image is generated according to the (x, y) pixel points.

In a second aspect, the present application provides a computer storage medium, and when the computer program is executed by a processor, the above-mentioned method for generating an aortic pressure waveform image is implemented.

The beneficial effects brought by the solutions provided in the embodiments of the present application include at least:

The present application provides a method for generating an aortic pressure waveform image, which can quickly and intuitively display data, accurately participate in calculation, and help doctors grasp changes in aortic pressure.

Description of drawings

The accompanying drawings described herein are used to provide further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the attached image:

1 is a flowchart of a method for generating an aortic pressure waveform image according to the present application;

FIG. 2 is a flowchart of the application S200;

FIG. 3 is a flowchart of the application S220;

FIG. 4 is a flowchart of the application S230;

5 is a flowchart of the application S232;

6 is a flowchart of the application S234;

7 is a flowchart of the application S240;

FIG. 8 is a flowchart of the application S250;

9 is a flowchart of the application S300;

FIG. 10 is a flowchart of S400 of the application;

11 is a flowchart of the application S500;

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the specific embodiments of the present invention and the corresponding drawings. Obviously, the described embodiments are only some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

Various embodiments of the present invention will be disclosed in the drawings below, and for the sake of clarity, many practical details will be described together in the following description. It should be understood, however, that these practical details should not be used to limit the invention. That is, in some embodiments of the invention, these practical details are unnecessary. In addition, for the purpose of simplifying the drawings, some well-known structures and components will be shown in a simple schematic manner in the drawings.

Example 1:

As shown in FIG. 1 , in order to solve the above problems, the present application provides a method for generating an aortic pressure waveform image provided by the present application, including:

S100, acquire data of aortic pressure _Pa , including:

Obtain aortic inlet pressure with a disposable blood pressure sensor.

S200, as shown in Figure 2, extracts _a stable pressure waveform according to the aortic pressure Pa, including:

S210, setting multiple index lists and physiological parameter thresholds;

The multiple index lists include: a temporary storage list, a save list, a mean point index list, a maximum value point index list, and a minimum value point index list.

Physiological parameter thresholds include: number of heartbeat cycles C, diastolic to systolic pressure range, minimum pressure amplitude threshold, systolic or diastolic pressure fluctuation difference, heart rate range, pressure number N _threshold , upper limit of the number of files, _cut -off pressure threshold P, Cut-off heart rate threshold HR _cutoff , pressure transmission rate _{threshold Vthreshold} .

S220, as shown in FIG. 3, calculates the average pressure according to the index list, the physiological parameter threshold, and the aortic pressure data, including:

S221, obtaining a heartbeat cycle time threshold according to the heart rate threshold;

S222, obtain the data point number scope in a heartbeat cycle according to a heartbeat cycle quantity C and a pressure transmission rate threshold;

S223, define a time period according to the range of the number of data points, count the number of all data points every time a time period ends, and store all acquired aortic pressures and acquired times in a temporary storage list in one-to-one correspondence Inside;

If _n consecutive aortic pressures Pa in the temporary storage list are all smaller than the _cut -off pressure threshold Pt, then remove _n aortic pressures Pa from the temporary storage list, reduce the calculation amount, and improve the running speed.

S224, if the number of data in the temporary storage list is an integer multiple of the N _threshold , greater than the minimum threshold of the range of the number of data points, and less than the maximum threshold of the range of the number of data points, calculate the aortas in all the temporary storage lists The average value of the pressure is the average pressure.

S230, as shown in Figure 4, obtains the pressure mean point according to the mean pressure, including:

S231, set the mean point index list;

S232, as shown in Figure 5, adding pressure mean points to the mean point index list, including:

_S2321 , compare the aortic pressure Pa in the temporary storage list with the average pressure respectively

Compare;

S2322, if

and

Then add PK to the mean point index list, where PK and _PK+1 represent the _Kth and _K +1th aortic pressures in the temporary storage list, respectively;

S2323, if

and

Then add _PK to the list of mean point indices.

S233, generating a pressure mean point curve according to the pressure mean point;

S234, as shown in Figure 6, filter the pressure mean point on the pressure mean point curve, including:

S2341, according to D _n =P _n+1 -P _n , where P _n and P _n+1 represent the nth and n+1th aortic pressures in the mean point index list, respectively, and D _n represent P _n+1 , The pressure difference of P _n ;

S2342, according to HR _n =30/(D _n /n), obtain the heart rate frequency value HR _n in the nth half heartbeat cycle;

S2343, if HR _n <HR _cutoff , delete the mean pressure point corresponding to HR _n from the mean point index list;

S2344 if

And after P _n m consecutive aortic pressures are greater than

and

Then delete m consecutive pressure mean points after P _n from the mean point index list.

S235, determine whether the number of pressure mean points in the mean point index list meets the heartbeat cycle requirements, if not, repeat the above method, adjust the size of n, until the heartbeat cycle requirements are met, including:

Adjust the size of n until N _is ≥ 2C+1.

S240, as shown in FIG. 7, the data period is divided according to the pressure mean point, and the pressure parameters in each heartbeat period are obtained, including:

S241, if

Extract the maximum pressure P _max in the heartbeat cycle where P _n is located and the position S _max where the maximum pressure P _max is located from the temporary storage list, and add S _max and P _max to the diastolic pressure list in a one-to-one correspondence;

S242, obtain the average value of _Pmax in the diastolic blood pressure list, and obtain the diastolic blood pressure _Pshu ;

If _Pshu is not within the range of diastolic blood pressure to systolic blood pressure, re-acquire the temporary storage list, including: truncate the first half of the temporary storage list into the saved list. The first half of the data in the temporary storage list is directly replaced into the temporary storage list, and the save list is cleared.

S243 if

Extract the minimum pressure P _min in the heartbeat cycle where P _n is located and the position S _min where the minimum pressure P _min is located from the temporary storage list, and add S _min and P _min to the systolic blood pressure list in a one-to-one correspondence;

S244, obtain the average value of P _min in the systolic blood pressure list, and obtain the systolic blood pressure P _close .

S250, as shown in Fig. 8, obtains a stable pressure waveform according to the pressure parameters, including:

S251, set the offset to V _threshold /a, and intercept the starting point O and the ending point E;

S252: Execute the average point index list, the diastolic blood pressure list, and the systolic blood pressure list according to the above offset, start point O, and end point E, and output a stable pressure waveform, a diastolic pressure waveform, and a systolic pressure waveform.

S300, as shown in FIG. 9, setting the display interval of the smooth pressure waveform, including:

S310, setting the length W ₁ and the width H ₁ of the generated aortic pressure waveform image;

S320, setting the outer frame length W ₂ and width H ₂ of the aortic pressure waveform image;

S330, according to W=W ₁ -2W ₂ and H=H ₁ -2H ₂ , obtain the length W and the width H of the display interval of the stable pressure waveform.

S400, as shown in Figure 10, set the data range of the smooth pressure waveform, including:

S410, set the X-axis duty cycle threshold of the stable pressure waveform, and the interpolation number between the two intersection points of the stable pressure waveform and the X-axis; set the sampling interval; by adjusting the interpolation number and the X-axis Sampling interval time, to obtain the X-axis data range where the X-axis duty cycle of the stable pressure waveform is greater than or equal to the X-axis duty cycle threshold;

S420, set the Y-axis duty cycle threshold to r, and set the ratio of the data range to the display space to be a; then the Y-axis data length is L=( _Pshu - _Pclose )+( _Pshu -P The minimum value of _the Y-axis data y _min =P _close- (P _Shu -P _close )/ar; The Y-axis data maximum value y _max =P _Shu + (P _Shu - P _close )/ar ; The Y-axis data range of the steady pressure is [y _min , y _max ].

S500, as shown in FIG. 11, generate an aortic pressure waveform image according to the display interval, data range and stable pressure waveform, including:

S510, create a new image space with a length of W and a width of H;

S520, setting the background color or background picture of the picture space, and adding a border;

S530, set the color of the (x, y) pixel;

S540, the X-axis display pixel range is [W ₂ , W ₁ -1-W ₂ ], and the Y-axis display pixel range is [H ₂ , H ₁ -1-H ₂ ];

S550, generate an aortic pressure waveform image according to the (x, y) pixel points.

In an embodiment of the present application, the method further includes: obtaining the heart rate HR according to the stable pressure waveform and HR=60V _threshold /( _Naverage /C).

The present application provides a computer storage medium, and when the computer program is executed by a processor, the above-mentioned method for generating an aortic pressure waveform image is implemented.

As will be appreciated by one skilled in the art, various aspects of the present invention may be embodied as a system, method or computer program product. Accordingly, various aspects of the present invention may be embodied in the form of an entirely hardware implementation, an entirely software implementation (including firmware, resident software, microcode, etc.), or a combination of hardware and software aspects, It may be collectively referred to herein as a "circuit," "module," or "system." Furthermore, in some embodiments, various aspects of the present invention may also be implemented in the form of a computer program product on one or more computer-readable media having computer-readable program code embodied thereon. Implementation of the method and/or system of embodiments of the present invention may involve performing or completing selected tasks manually, automatically, or a combination thereof.

For example, hardware for performing selected tasks according to embodiments of the invention may be implemented as a chip or a circuit. As software, selected tasks according to embodiments of the invention may be implemented as a plurality of software instructions executed by a computer using any suitable operating system. In an exemplary embodiment of the invention, one or more tasks according to exemplary embodiments of a method and/or system as herein are performed by a data processor, such as a computing platform for executing a plurality of instructions. Optionally, the data processor includes volatile storage for storing instructions and/or data and/or non-volatile storage for storing instructions and/or data, such as a magnetic hard disk and/or a Move media. Optionally, a network connection is also provided. A display and/or user input device, such as a keyboard or mouse, is optionally also provided.

Any combination of one or more computer readable may be utilized. The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. The computer-readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus or device, or a combination of any of the above. More specific examples (non-exhaustive list) of computer-readable storage media would include the following:

Electrical connection with one or more wires, portable computer disk, hard disk, random access memory (RAM), read only memory (ROM), erasable programmable read only memory (EPROM or flash memory), optical fiber, portable compact disk Read only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination of the above. In this document, a computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.

A computer-readable signal medium may include a propagated data signal in baseband or as part of a carrier wave, with computer-readable program code embodied thereon. Such propagated data signals may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the foregoing. A computer-readable signal medium can also be any computer-readable medium other than a computer-readable storage medium that can transmit, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device .

Program code embodied on a computer-readable medium may be transmitted using any suitable medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.

For example, computer program code for performing operations for various aspects of the invention may be written in any combination of one or more programming languages, including object-oriented programming languages such as Java, Smalltalk, C++, and conventional procedural programming languages, such as The "C" programming language or similar programming language. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer, or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any kind of network - including a local area network (LAN) or a wide area network (WAN) - or may be connected to an external computer (eg using an Internet service provider via Internet connection).

It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to the processor of a general purpose computer, special purpose computer or other programmable data processing apparatus to produce a machine that causes the computer program instructions when executed by the processor of the computer or other programmable data processing apparatus , resulting in means for implementing the functions/acts specified in one or more blocks of the flowchart and/or block diagrams.

These computer program instructions can also be stored on a computer readable medium, the instructions cause a computer, other programmable data processing apparatus, or other device to operate in a particular manner, whereby the instructions stored on the computer readable medium produce the An article of manufacture of instructions implementing the functions/acts specified in one or more blocks of the flowcharts and/or block diagrams.

Computer program instructions can also be loaded on a computer (eg, a coronary artery analysis system) or other programmable data processing device to cause a series of operational steps to be performed on the computer, other programmable data processing device or other device to produce a computer-implemented process , such that instructions executing on a computer, other programmable apparatus, or other device provide a process for implementing the functions/acts specified in the flowchart and/or one or more block diagram blocks.

The above specific examples of the present invention further describe the purpose, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above are only specific embodiments of the present invention, and are not intended to limit the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

A method for generating an aortic pressure waveform image, comprising:

Obtain aortic pressure Pa data;

extracting a stable pressure waveform according to the aortic pressure Pa;

setting the display interval of the stable pressure waveform;

setting the data range of the smooth pressure waveform;

The aortic pressure waveform image is generated according to the display interval, the data range and the smooth pressure waveform.
The method for generating aortic pressure waveform images according to claim 1, wherein the method for acquiring data of aortic pressure Pa comprises:

Obtain aortic inlet pressure with a disposable blood pressure sensor.
The method for generating an aortic pressure waveform image according to claim 1, wherein the method for extracting a stable pressure waveform according to the aortic pressure Pa comprises:

Set multiple index lists and physiological parameter thresholds;

Calculate the average pressure according to the index list, the physiological parameter threshold, and the aortic pressure data;

Obtain a pressure mean point according to the mean pressure;

Divide the data period according to the pressure mean point, and obtain the pressure parameters in each heartbeat period;

According to the pressure parameters, a stable pressure waveform is obtained.
The method for generating an aortic pressure waveform image according to claim 3, wherein the multiple index lists include: a temporary storage list, a save list, an index list of mean points, a list of maximum point indexes, and a list of minimum values Point index list.
The method for generating an aortic pressure waveform image according to claim 3, wherein the physiological parameter threshold comprises: the number of heartbeat cycles C, the range from diastolic to systolic pressure, the minimum pressure amplitude threshold, the systolic or diastolic pressure Fluctuation difference, heart rate range, N threshold for the number of pressures, upper limit for the number of files, cut -off pressure threshold P, cut -off heart rate threshold HR, and pressure transmission rate threshold V threshold .
The method for generating an aortic pressure waveform image according to claim 3, wherein the method for calculating the average pressure from the aortic pressure data according to the index list and the physiological parameter threshold value comprises:

Obtain a heartbeat cycle time threshold according to the heart rate threshold;

Acquire the range of the number of data points in a described heartbeat cycle according to a described heartbeat cycle quantity C and a pressure transmission rate threshold;

A time period is defined according to the range of the number of data points. After each time period ends, the number of all data points is counted, and all acquired aortic pressures and acquired times are stored in the temporary stored in the list;

If the number of data in the temporary storage list is an integer multiple of the N threshold , and is greater than the minimum threshold of the range of the number of data points, and less than the maximum threshold of the range of the number of data points, calculate the aorta in all temporary storage lists The average value of the pressure is the average pressure.
The method for generating an aortic pressure waveform image according to claim 6, wherein the method for calculating the average pressure from the aortic pressure data according to the index list and the physiological parameter threshold further comprises:

If the n consecutive aortic pressures Pa in the temporary storage list are all smaller than the cut -off pressure threshold Pt, the n aortic pressures Pa are removed from the temporary storage list.
The method for generating an aortic pressure waveform image according to claim 6, wherein the method for obtaining a pressure mean point according to the mean pressure comprises:

set mean point index list;

adding pressure mean points to the mean point index list;

Generate a pressure mean point curve according to the pressure mean point;

filtering pressure mean points on the pressure mean point curve;

Determine whether the number of the pressure mean points in the mean point index list meets the heartbeat cycle requirement, if not, repeat claim 7, and adjust the size of n until the heartbeat cycle requirement is met.
The method for generating an aortic pressure waveform image according to claim 8, wherein the method for adding a pressure mean point to the mean point index list comprises:

Compare the aortic pressure Pa in the temporary storage list with the average pressure
Compare;

if
and
Then add PK to the mean point index list, wherein PK and PK+1 represent the Kth and K +1th aortic pressures in the temporary storage list, respectively;

if
and
Then add PK to the list of mean point indices.
The method for generating an aortic pressure waveform image according to claim 9, wherein the method for filtering the pressure mean point on the pressure mean point curve comprises:

According to D n =P n+1 -P n , where P n and P n+1 represent the nth and n+1th aortic pressures in the mean point index list, respectively, and the D n represents P n+ 1. The pressure difference of P n ;

According to HR n =30/(D n /n), obtain the heart rate frequency value HR n in the nth half heartbeat cycle;

If HR n <HR cutoff , delete the mean pressure point corresponding to the HR n from the mean point index list;

if
And after P n m consecutive aortic pressures are greater than
and
Then, m consecutive pressure mean points after P n are deleted from the mean point index list.
The method for generating an aortic pressure waveform image according to claim 10, wherein the determining whether the number of the pressure mean points in the mean point index list meets the heartbeat cycle requirement, and if not, repeating the Described claim 6, adjust the size of n, until the method that meets the heartbeat cycle requirement comprises:

If the number N of data in the mean point list is all <2C+1, the heartbeat cycle requirement is not met, and the claim 6 is repeated;

Adjust the size of n until N is ≥ 2C+1.
The method for generating an aortic pressure waveform image according to claim 11, wherein the method for obtaining the pressure parameters in each heartbeat cycle by dividing the data period according to the pressure mean point comprises:

if
Extract the maximum pressure P max in the heartbeat cycle where P n is located and the position S max where the maximum pressure P max is located from the temporary storage list, and add the S max and P max to the diastolic pressure list in one-to-one correspondence ;

Obtain the average value of Pmax in the diastolic blood pressure list, and obtain the diastolic blood pressure Pshu ;

if
Extract the minimum pressure P min in the heartbeat cycle where P n is located and the position S min where the minimum pressure P min is located from the temporary storage list, and add the S min and P min to the systolic blood pressure list in one-to-one correspondence ;

Obtain the average value of P min in the systolic blood pressure list to obtain the systolic blood pressure P close .
The method for generating an aortic pressure waveform image according to claim 12, wherein if Pshu is not within the range of diastolic blood pressure to systolic blood pressure, the temporary storage list is re-acquired.
The method for generating an aortic pressure waveform image according to claim 13, wherein the method for re-acquiring the temporary storage list if Pshu is not within the range of diastolic blood pressure to systolic blood pressure comprises: converting the The first half of the temporary storage list is intercepted into the storage list, and if the number of data is greater than the upper limit of the number of storage lists, the first half of the data in the temporary storage list using the storage list is directly replaced into the temporary storage list. , and clears the save list.
The method for generating an aortic pressure waveform image according to claim 13, wherein the method for obtaining a stable pressure waveform according to the pressure parameter comprises:

Set the offset to Vthreshold /a, and intercept the start point O and end point E;

The average point index list, the diastolic pressure list, and the systolic pressure list are all executed according to the above offset, start point O, and end point E, and output the stable pressure waveform, diastolic pressure waveform, and systolic pressure waveform.
The method for generating an aortic pressure waveform image according to claim 13, further comprising: obtaining the heart rate HR according to the stable pressure waveform and HR=60V threshold /( Naverage /C).
The method for generating an aortic pressure waveform image according to claim 1, wherein the method for setting the display interval of the stable pressure waveform comprises:

setting the length W 1 and the width H 1 of the generated aortic pressure waveform image;

setting the outer frame length W 2 and width H 2 of the aortic pressure waveform image;

According to W=W 1 -2W 2 and H=H 1 -2H 2 , the length W and the width H of the display interval of the steady pressure waveform are obtained.
The method for generating an aortic pressure waveform image according to claim 17, wherein the method for setting the data range of the stable pressure waveform comprises:

Set the X-axis duty cycle threshold of the stable pressure waveform, and the interpolation number between the two intersection points of the stable pressure waveform and the X-axis; set the sampling interval time; by adjusting the interpolation number and the sampling interval time, to obtain the data range of the X-axis where the X-axis duty cycle of the stable pressure waveform is greater than or equal to the X-axis duty cycle threshold; and/or

Set the Y-axis duty cycle threshold to r, and set the ratio of the data range to the display space to be a; then the Y-axis data length is L=(P Shu -P Close )+(P Shu -P Close ) /r; the minimum value of the Y-axis data ymin =P close- ( Pshu - Pclose )/ar; the maximum value of the Y-axis data ymax = Pshu +( Pshu - Pclose )/ar; The Y-axis data range of the stationary pressure is [y min , y max ].
The method for generating an aortic pressure waveform image according to claim 18, wherein the method for generating the aortic pressure waveform image according to the display interval, the data range and the stable pressure waveform comprises:

Create a new image space of length W and width H;

Set the background color or background picture of the picture space, and add a border;

Set the color of (x, y) pixels;

The X-axis display pixel range is [W 2 ,W 1 -1-W 2 ], and the Y-axis display pixel range is [H 2 ,H 1 -1-H 2 ];

The aortic pressure waveform image is generated according to the (x, y) pixel points.
A computer storage medium, characterized in that, when the computer program is executed by a processor, the method for generating an aortic pressure waveform image according to any one of claims 1 to 19 is implemented.