WO2022109907A1

WO2022109907A1 - Method and storage medium for precise acquisition of stenotic lesion range

Info

Publication number: WO2022109907A1
Application number: PCT/CN2020/131703
Authority: WO
Inventors: 王鹏; 刘广志; 王之元; 徐磊
Original assignee: 苏州润迈德医疗科技有限公司
Priority date: 2020-11-25
Filing date: 2020-11-26
Publication date: 2022-06-02
Also published as: CN112419280A

Abstract

Provided are a method and storage medium for the precise acquisition of a stenotic lesion range, comprising: performing three-dimensional modeling according to a real-time vessel diameter Dt, a vessel centerline length L, and a stenosis range to form a mathematical model having a narrow lesion range (S100); preliminary determination to obtain a first stenotic lesion range (S200); removing erroneously determined stenotic regions from the first stenotic lesion range to obtain a second stenotic lesion range (S300). In the method and storage medium for the precise acquisition of a stenotic lesion range, by means of modeling a vascular wall in three dimensions after refitting, and further correcting for coarse-precision vascular stenosis, the accuracy of a narrow lesion range is ensured.

Description

Method and storage medium for accurately obtaining stenotic lesion interval

technical field

The invention relates to the technical field of coronary medicine, in particular to a method and a storage medium for accurately acquiring a stenotic lesion interval.

Background technique

The deposition of lipids and carbohydrates in human blood on the blood vessel wall will form plaques on the blood vessel wall, which will then lead to vascular stenosis; especially the vascular stenosis near the coronary arteries of the heart will lead to insufficient blood supply to the heart muscle and induce coronary heart disease. , angina pectoris and other diseases pose a serious threat to human health. According to statistics, there are about 11 million coronary heart disease patients in my country, and the number of patients treated with cardiovascular interventional surgery is increasing by more than 10% every year.

Although conventional medical detection methods such as coronary angiography (CAG) and computed tomography (CT) can display the severity of coronary artery stenosis, they cannot accurately evaluate coronary ischemia. In order to improve the accuracy of coronary vascular function evaluation, in 1993, Pijls proposed a new index for calculating coronary vascular function through pressure measurement - Fractional Flow Reserve (FFR). After long-term basic and clinical research, FFR It has become the gold standard for functional evaluation of coronary stenosis.

FFR is one of the coronary vascular evaluation parameters, and the microcirculation resistance index IMR belongs to the coronary vascular evaluation parameters.

Although the existing technology can obtain the stenotic lesion interval through different methods, all of them are by defining the stenotic position, extending from the stenotic position to both ends, and extending to the preset parameters to obtain the starting position and ending position of the stenotic lesion, thereby obtaining the stenotic lesion. interval. In practice, the fixed preset parameters are unable to cope with the diversity of blood vessels, resulting in insufficient intensive reading of the stenotic lesion interval.

SUMMARY OF THE INVENTION

The present invention provides a method and a storage medium for accurately acquiring stenotic lesion intervals, so as to solve the problem of insufficient precision of stenotic lesion intervals due to the inability of fixed preset parameters to deal with the diversity of blood vessels.

In order to achieve the above object, in a first aspect, the present application provides a method for accurately obtaining a narrow lesion interval, including:

According to the real-time diameter D _t of the blood vessel, the length L of the center line of the blood vessel and the stenosis interval, three-dimensional modeling is performed to form a mathematical model with stenotic lesion interval;

Preliminary judgment to obtain the first stenotic lesion interval;

The misjudged stenotic region is removed from the first stenotic lesion interval to obtain a second stenotic lesion interval.

Optionally, in the above-mentioned method for accurately obtaining a narrow lesion interval, the preliminary judgment, the method for obtaining the first narrow lesion interval, includes:

Fit the normal blood vessel diameter and obtain the fitted diameter curve;

Obtain the real pipe diameter curve according to the mathematical model;

According to the fitted diameter curve and the real diameter curve, the first stenosis lesion interval is obtained.

Optionally, in the above-mentioned method for accurately obtaining a stenotic lesion interval, the method for fitting a normal blood vessel diameter and obtaining a fitting diameter curve includes:

According to the fitting cost function, the fitted pipe diameter is obtained, and the specific formula is:

Among them, i represents the curve sampling point of the ith pipe diameter; n represents the sum of the number of pipe diameter curve sampling; _xi represents the length of the curve sampling point of the ith pipe diameter; y _i represents the pipe diameter at _xi ;

Corresponding each of the fitted pipe diameters to a coordinate system to obtain a corresponding pipe diameter point, and smoothly connecting the pipe diameter points in turn to obtain the fitted pipe diameter curve.

Optionally, in the above-mentioned method for accurately obtaining a stenotic lesion interval, the method for obtaining the first stenosis position according to the fitted diameter curve and the real diameter curve includes:

Obtain the true diameter of the blood vessel;

Corresponding the real pipe diameter to the coordinate system of the fitted pipe diameter curve;

Obtain the true pipe diameter curve, and the intersection of the true pipe diameter curve and the fitted pipe diameter curve;

If the real pipe diameter at a point before the intersection is larger than the fitted pipe diameter, the intersection is the first entry point of the narrow area, otherwise, the intersection is the first exit of the narrow area point;

The curve between the first entry point and the first exit point is the preliminarily determined stenosis position, that is, the first stenotic lesion interval.

Optionally, in the above-mentioned method for accurately obtaining a narrow lesion interval, the method for removing a misjudged narrow lesion area from the first narrow lesion interval to obtain a second narrow lesion interval includes;

Calculate stenosis;

calculating the length L of the blood vessel centerline of the first stenotic lesion interval;

The misjudged stenosis region is removed from the first stenotic lesion interval according to the stenosis degree and the length of the blood vessel center line to obtain a second stenotic lesion interval.

Optionally, in the above-mentioned method for accurately obtaining a stenotic lesion interval, the method for calculating a stenosis degree includes:

Among them, A represents the stenosis degree of the blood vessel, D _min represents the minimum diameter of the blood vessel between the first entry point and the first exit point, D _in and D _out represent the vessel diameter of the first entry point and the first exit point, respectively vascular diameter.

Optionally, in the above-mentioned method for accurately obtaining a stenotic lesion interval, the method for obtaining a second stenotic lesion interval by removing a misjudged stenotic area from the first stenotic lesion interval according to the stenosis degree and the length of the blood vessel centerline include:

If A<0.2, it is judged as a misjudged area, and the fitted pipe diameter curve in this area is used to replace the real pipe diameter curve in the misjudged area;

If L<5mm, it is judged as a misjudged area, and the fitted pipe diameter curve in this area is used to replace the real pipe diameter curve in the misjudged area;

The stenotic area obtained after removing the misjudged area is the second stenotic lesion interval.

Optionally, the above-mentioned method for accurately obtaining a narrow lesion interval further includes:

Take the area between 1-3 cm before the first entry point and 1-3 cm after the first exit point, and re-fit the pipe diameter interval curve according to the fitting cost function;

Obtain the point with the smallest pipe diameter in the refitted pipe diameter interval curve as the narrow point;

On both sides of the narrow point, the two points where the fitted pipe diameter interval curve and the real pipe diameter curve intersect are a second entry point and a second exit point, and the second entry point and the second The interval between the exit points is the third stenotic lesion interval.

Optionally, the above-mentioned method for accurately obtaining the stenotic lesion interval, the method for performing three-dimensional modeling according to the real-time diameter D _t of the blood vessel, the blood vessel centerline length L and the stenotic interval to form a mathematical model with the stenotic lesion interval, includes:

3D modeling is carried out according to the real-time diameter D _t of the blood vessel, the length L of the blood vessel center line and the stenosis interval to form a 3D vessel model with stenotic lesion interval;

N-edge meshing is performed along the circumference of the three-dimensional blood vessel model with stenotic lesions to form a single-layer mesh model, where N≥6;

The surface layering process is performed on the single-layer grid model to form a double-layer grid model, that is, a blood vessel mathematical model.

Optionally, in the above-mentioned method for accurately obtaining stenotic lesion intervals, N-edge meshing is performed along the circumference of the three-dimensional blood vessel model with stenotic lesion intervals to form a single-layer grid model, where N≥ 6 methods include:

along the circumference of the three-dimensional blood vessel model with the stenotic lesion interval, meshing is performed with triangles as the smallest unit;

According to the sequence, every N triangle combination is converted into an N-sided shape to form an N-sided initial mesh;

The connecting lines inside each N-gon in the N-sided initial grid are deleted to form a single-layer N-sided grid model, where N≥6.

Optionally, in the above-mentioned method for accurately acquiring stenotic lesion intervals, the method for meshing along the circumference of the three-dimensional blood vessel model with stenotic lesion intervals using triangles as the smallest unit includes:

segmenting the three-dimensional vessel model with stenotic lesion intervals into K segments,

On the circumferential surface of the three-dimensional blood vessel model in each segment, a triangle is used as the smallest unit for mesh division.

Optionally, in the above-mentioned method for accurately obtaining a stenotic lesion interval, the method for performing surface layering processing on the single-layer grid model to form a double-layer grid model, that is, a blood vessel mathematical model, includes:

Obtain the vessel wall thickness h;

Three-dimensional modeling is performed according to the blood vessel wall thickness h, the blood vessel _starting diameter D, the blood vessel ending diameter _D and the blood vessel centerline length L, and a three-dimensional truncated truncated model is formed on the inner surface or outer surface of the single-layer mesh model;

According to the method for obtaining the single-layer grid model, N-edge grid division is performed along the circumference of the three-dimensional truncated truncated model to form another single-layer grid model;

Two layers of the single-layer grid model and the blood vessel wall thickness h form the double-layer grid model, that is, the blood vessel mathematical model.

In a second aspect, the present application provides a computer storage medium, and when the computer program is executed by a processor, the above-mentioned method for accurately acquiring a narrow lesion interval can be implemented.

The beneficial effects brought by the solutions provided in the embodiments of the present application include at least:

The present application provides a method and a storage medium for accurately obtaining a stenosis lesion interval, and further corrects the vascular stenosis with coarse precision by refitting the three-dimensional modeling of the vessel wall to ensure the accuracy of the stenosis lesion interval.

Description of drawings

The accompanying drawings described herein are used to provide further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the attached image:

FIG. 1 is a flowchart of an embodiment of a method for accurately obtaining a narrow lesion interval according to the present application;

Fig. 2 is the flow chart of S100 of this application;

3 is a flowchart of S120 of the application;

4 is a flowchart of S130 of the application;

Fig. 5 is the flow chart of S200 of this application;

6 is a flowchart of S210 of the application;

FIG. 7 is a flowchart of S230 of the application;

8 is a flowchart of S300 of the application;

9 is a flowchart of S330 of the application;

FIG. 10 is a flowchart of another embodiment of the method for accurately obtaining a stenotic lesion interval according to the present application.

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the specific embodiments of the present invention and the corresponding drawings. Obviously, the described embodiments are only some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

Various embodiments of the present invention will be disclosed in the drawings below, and for the sake of clarity, many practical details will be described together in the following description. It should be understood, however, that these practical details should not be used to limit the invention. That is, in some embodiments of the invention, these practical details are unnecessary. In addition, for the purpose of simplifying the drawings, some well-known structures and components will be shown in a simple schematic manner in the drawings.

Example 1:

As shown in FIG. 1 , the present application provides a method for accurately obtaining a narrow lesion interval, including:

S100 , as shown in FIG. 2 , three-dimensional modeling is performed according to the real-time diameter D _t of the blood vessel, the length L of the blood vessel centerline and the stenosis interval, to form a mathematical model with a stenotic lesion interval, including:

S110, perform three-dimensional modeling according to the real-time diameter D _t of the blood vessel, the length L of the blood vessel center line and the stenosis interval, to form a three-dimensional blood vessel model with a stenotic lesion interval;

S120 , as shown in FIG. 3 , N-edge meshing is performed along the circumference of the three-dimensional blood vessel model with stenotic lesions to form a single-layer mesh model, where N≥6, including:

S121 , along the circumference of the three-dimensional blood vessel model with the stenotic lesion interval, perform grid division with triangles as the smallest unit, including: dividing the three-dimensional blood vessel model with the narrow lesion interval into K segments, and in each segment of the three-dimensional blood vessel model On the circumferential surface, the triangle is used as the smallest element for mesh division.

S122, according to the sequence, every N triangle combination is converted into an N-sided shape to form an N-sided initial mesh;

S123 , delete the connecting lines inside each N-gon in the N-sided initial grid to form a single-layer N-sided grid model, where N≥6.

S130, as shown in FIG. 4, the surface layering process is performed on the single-layer grid model to form a double-layer grid model, that is, a blood vessel mathematical model, including:

S131, obtaining the blood vessel wall thickness h;

S132, perform three-dimensional modeling according to the blood vessel wall thickness h, the blood vessel _starting diameter D, the blood vessel ending diameter _D and the blood vessel centerline length L, and form a three-dimensional truncated truncated model on the inner surface or outer surface of the single-layer mesh model;

S133, according to the obtaining method of the single-layer mesh model, carry out N-edge mesh division along the circumferential surface of the three-dimensional truncated truncated model to form another single-layer mesh model;

S134, the two-layer single-layer grid model and the blood vessel wall thickness h form a double-layer grid model, that is, a blood vessel mathematical model.

S200, as shown in Fig. 5, preliminarily judges and obtains the first stenotic lesion interval, including:

S210, as shown in FIG. 6, fitting a normal blood vessel diameter, and obtaining a fitting diameter curve, including:

S211, according to the fitting cost function, obtain the fitting pipe diameter, and the specific formula is:

S212: Corresponding each fitted pipe diameter to a coordinate system to obtain a corresponding pipe diameter point, and smoothly connecting the pipe diameter points in turn to obtain a fitted pipe diameter curve.

S220, obtaining the real pipe diameter curve according to the mathematical model;

S230, as shown in FIG. 7, according to the fitted diameter curve and the real diameter curve, obtain a first stenosis lesion interval, including:

S231, obtain the real diameter of the blood vessel;

S232, corresponding the real pipe diameter to the coordinate system of the fitted pipe diameter curve;

S233, obtaining the real pipe diameter curve and the intersection point of the real pipe diameter curve and the fitted pipe diameter curve;

S234, if the real pipe diameter at the point before the intersection is larger than the fitted pipe diameter, the intersection is the first entry point of the narrow area, otherwise, the intersection is the first exit point of the narrow area;

S235, the curve between the first entry point and the first exit point is the initially determined stenosis position, that is, the first stenotic lesion interval.

S300 , as shown in FIG. 8 , the misjudged stenosis area is removed from the first stenotic lesion interval to obtain a second stenotic lesion interval, including:

S310, calculate the stenosis, and the specific formula is:

S320, calculating the length L of the center line of the blood vessel in the first stenotic lesion interval;

S330 , as shown in FIG. 9 , according to the stenosis degree and the length of the blood vessel centerline, the misjudged stenosis area is removed from the first stenotic lesion interval, and the second stenotic lesion interval is obtained, including:

S331, if A<0.2, it is judged as a misjudged area, and the fitted pipe diameter curve in this area is used to replace the real pipe diameter curve in the misjudged area;

S332, if L<5mm, it is judged as a misjudged area, and the fitted pipe diameter curve in this area is used to replace the real pipe diameter curve in the misjudged area;

S333 , the stenotic area obtained again after removing the misjudged area is the second stenotic lesion interval.

Example 2:

As shown in FIG. 10 , on the basis of Embodiment 1, a method for accurately obtaining a narrow lesion interval provided by the present application further includes:

S400, take the area between 1-3 cm before the first entry point and 1-3 cm after the first exit point, and re-fit the pipe diameter interval curve according to the fitting cost function;

S500, obtaining the point with the smallest pipe diameter in the re-fitted pipe diameter interval curve as the narrow point;

S600, on both sides of the narrow point, the two points where the fitted pipe diameter interval curve and the real pipe diameter curve intersect are the second entry point and the second exit point, and the interval between the second entry point and the second exit point is the second entry point and the second exit point. Three stenotic lesions.

The present application provides a computer storage medium, and when the computer program is executed by a processor, the above-mentioned method for accurately acquiring a narrow lesion interval can be implemented.

As will be appreciated by one skilled in the art, various aspects of the present invention may be embodied as a system, method or computer program product. Accordingly, various aspects of the present invention may be embodied in the form of an entirely hardware implementation, an entirely software implementation (including firmware, resident software, microcode, etc.), or a combination of hardware and software aspects, It may be collectively referred to herein as a "circuit," "module," or "system." Furthermore, in some embodiments, various aspects of the present invention may also be implemented in the form of a computer program product on one or more computer-readable media having computer-readable program code embodied thereon. Implementation of the method and/or system of embodiments of the invention may involve performing or completing selected tasks manually, automatically, or a combination thereof.

For example, hardware for performing selected tasks according to embodiments of the invention may be implemented as a chip or a circuit. As software, selected tasks according to embodiments of the invention may be implemented as a plurality of software instructions executed by a computer using any suitable operating system. In an exemplary embodiment of the invention, one or more tasks in accordance with exemplary embodiments of methods and/or systems as herein are performed by a data processor, such as a computing platform for executing a plurality of instructions. Optionally, the data processor includes volatile storage for storing instructions and/or data and/or non-volatile storage for storing instructions and/or data, such as a magnetic hard disk and/or a Move media. Optionally, a network connection is also provided. A display and/or user input device, such as a keyboard or mouse, is optionally also provided.

Any combination of one or more computer readable may be utilized. The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. The computer-readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus or device, or a combination of any of the above. More specific examples (non-exhaustive list) of computer-readable storage media would include the following:

Electrical connection with one or more wires, portable computer disk, hard disk, random access memory (RAM), read only memory (ROM), erasable programmable read only memory (EPROM or flash memory), optical fiber, portable compact disk Read only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination of the above. In this document, a computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.

A computer-readable signal medium may include a propagated data signal in baseband or as part of a carrier wave, with computer-readable program code embodied thereon. Such propagated data signals may take a variety of forms including, but not limited to, electromagnetic signals, optical signals, or any suitable combination of the foregoing. A computer-readable signal medium can also be any computer-readable medium other than a computer-readable storage medium that can transmit, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device .

Program code embodied on a computer-readable medium may be transmitted using any suitable medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.

For example, computer program code for performing operations for various aspects of the present invention may be written in any combination of one or more programming languages, including object-oriented programming languages such as Java, Smalltalk, C++, and conventional procedural programming languages, such as The "C" programming language or similar programming language. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer, or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any kind of network - including a local area network (LAN) or wide area network (WAN) - or may be connected to an external computer (eg using an Internet service provider via Internet connection).

It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to the processor of a general purpose computer, special purpose computer or other programmable data processing apparatus to produce a machine that causes the computer program instructions when executed by the processor of the computer or other programmable data processing apparatus , resulting in means for implementing the functions/acts specified in one or more blocks of the flowchart and/or block diagrams.

These computer program instructions can also be stored on a computer readable medium, the instructions cause a computer, other programmable data processing apparatus, or other device to operate in a particular manner, whereby the instructions stored on the computer readable medium produce the An article of manufacture of instructions implementing the functions/acts specified in one or more blocks of the flowcharts and/or block diagrams.

Computer program instructions can also be loaded on a computer (eg, a coronary artery analysis system) or other programmable data processing device to cause a series of operational steps to be performed on the computer, other programmable data processing device or other device to produce a computer-implemented process , such that instructions executing on a computer, other programmable apparatus, or other device provide a process for implementing the functions/acts specified in the flowchart and/or one or more block diagram blocks.

The above specific examples of the present invention further describe the purpose, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above are only specific embodiments of the present invention, and are not intended to limit the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

A method for accurately obtaining a stenotic lesion interval, comprising:

According to the real-time diameter D t of the blood vessel, the length L of the center line of the blood vessel and the stenosis interval, three-dimensional modeling is performed to form a mathematical model with stenotic lesion interval;

Preliminary judgment to obtain the first stenotic lesion interval;

The misjudged stenotic region is removed from the first stenotic lesion section to obtain a second stenotic lesion section.
The method for accurately obtaining a narrow lesion interval according to claim 1, wherein the preliminary judgment, the method for obtaining the first narrow lesion interval, comprises:

Fit the normal blood vessel diameter and obtain the fitted diameter curve;

Obtain the real pipe diameter curve according to the mathematical model;

According to the fitted diameter curve and the real diameter curve, the first stenosis lesion interval is obtained.
The method for accurately obtaining a stenotic lesion interval according to claim 2, wherein the method for fitting a normal blood vessel diameter and obtaining a fitting diameter curve comprises:

According to the fitting cost function, the fitted pipe diameter is obtained, and the specific formula is:

Among them, i represents the curve sampling point of the ith pipe diameter; n represents the sum of the number of pipe diameter curve sampling; xi represents the length of the curve sampling point of the ith pipe diameter; y i represents the pipe diameter at xi ;

Corresponding each of the fitted pipe diameters to a coordinate system to obtain a corresponding pipe diameter point, and smoothly connecting the pipe diameter points in turn to obtain the fitted pipe diameter curve.
The method for accurately obtaining a stenotic lesion interval according to claim 3, wherein the method for obtaining the first stenosis position according to the fitted diameter curve and the real diameter curve comprises:

Obtain the true diameter of the blood vessel;

Corresponding the real pipe diameter to the coordinate system of the fitted pipe diameter curve;

Obtain the true pipe diameter curve, and the intersection of the true pipe diameter curve and the fitted pipe diameter curve;

If the real pipe diameter at a point before the intersection is larger than the fitted pipe diameter, the intersection is the first entry point of the narrow area, otherwise, the intersection is the first exit of the narrow area point;

The curve between the first entry point and the first exit point is the preliminarily determined stenosis position, that is, the first stenotic lesion interval.
The method for accurately obtaining a stenotic lesion interval according to claim 4, wherein the method for obtaining a second stenotic lesion interval by removing a misjudged stenotic area from the first stenotic lesion interval comprises;

Calculate stenosis;

calculating the length L of the blood vessel centerline of the first stenotic lesion interval;

The misjudged stenosis region is removed from the first stenotic lesion interval according to the stenosis degree and the length of the blood vessel center line to obtain a second stenotic lesion interval.
The method for accurately obtaining a stenotic lesion interval according to claim 5, wherein the method for calculating the stenosis degree comprises:

Among them, A represents the stenosis degree of the blood vessel, D min represents the minimum diameter of the blood vessel between the first entry point and the first exit point, D in and D out represent the vessel diameter of the first entry point and the first exit point, respectively vascular diameter.
The method for accurately obtaining a stenosis lesion section according to claim 6, wherein the stenosis region that is misjudged from the first stenosis lesion section is removed according to the stenosis degree and the length of the blood vessel centerline to obtain the second stenosis Methods of lesion interval include:

If A<0.2, it is judged as a misjudged area, and the fitted pipe diameter curve in this area is used to replace the real pipe diameter curve in the misjudged area;

If L<5mm, it is judged as a misjudged area, and the fitted pipe diameter curve in this area is used to replace the real pipe diameter curve in the misjudged area;

The stenotic area obtained after removing the misjudged area is the second stenotic lesion interval.
The method for accurately obtaining a narrow lesion interval according to claim 4, further comprising:

Take the area between 1-3 cm before the first entry point and 1-3 cm after the first exit point, and re-fit the pipe diameter interval curve according to the fitting cost function;

Obtain the point with the smallest pipe diameter in the refitted pipe diameter interval curve as the narrow point;

On both sides of the narrow point, the two points where the fitted pipe diameter interval curve and the real pipe diameter curve intersect are a second entry point and a second exit point, and the second entry point and the second The interval between the exit points is the third stenotic lesion interval.
The method for accurately obtaining a stenotic lesion interval according to claim 1, wherein the three-dimensional modeling is performed according to the real-time blood vessel diameter D t , the blood vessel centerline length L and the stenotic interval to form a mathematical model with a stenotic lesion interval. methods, including:

3D modeling is carried out according to the real-time diameter D t of the blood vessel, the length L of the blood vessel center line and the stenosis interval to form a 3D vessel model with stenotic lesion interval;

N-edge meshing is performed along the circumference of the three-dimensional blood vessel model with stenotic lesions to form a single-layer mesh model, where N≥6;

The surface layering process is performed on the single-layer grid model to form a double-layer grid model, that is, a blood vessel mathematical model.
The method for accurately obtaining a stenotic lesion interval according to claim 9, wherein the N-edge meshing is performed along the circumference of the three-dimensional blood vessel model with the stenotic lesion interval to form a single-layer grid model , where N≥6 methods include:

along the circumference of the three-dimensional blood vessel model with the stenotic lesion interval, meshing is performed with triangles as the smallest unit;

According to the sequence, every N triangle combination is converted into an N-sided shape to form an N-sided initial mesh;

The connecting lines inside each N-gon in the N-sided initial grid are deleted to form a single-layer N-sided grid model, where N≥6.
The method for accurately obtaining a stenotic lesion section according to claim 10, wherein the method for meshing along the circumference of the three-dimensional blood vessel model with the stenotic lesion section takes triangles as the smallest unit include:

segmenting the three-dimensional vessel model with stenotic lesion intervals into K segments,

On the circumferential surface of the three-dimensional blood vessel model in each segment, a triangle is used as the smallest unit for mesh division.
The method for accurately obtaining a stenotic lesion interval according to claim 11, wherein the method for performing surface layering processing on the single-layer grid model to form a double-layer grid model, that is, a blood vessel mathematical model, comprises the following steps: :

Obtain the vessel wall thickness h;

Three-dimensional modeling is performed according to the blood vessel wall thickness h, the blood vessel starting diameter D, the blood vessel ending diameter D and the blood vessel centerline length L, and a three-dimensional truncated truncated model is formed on the inner surface or outer surface of the single-layer mesh model;

According to the method for obtaining the single-layer grid model, N-edge grid division is performed along the circumference of the three-dimensional truncated truncated model to form another single-layer grid model;

Two layers of the single-layer grid model and the blood vessel wall thickness h form the double-layer grid model, that is, the blood vessel mathematical model.
A computer storage medium, characterized in that, when the computer program is executed by a processor, the method for accurately acquiring a narrow lesion interval according to any one of claims 1 to 12 is implemented.