WO2022109792A1 - 闭环超声刺激控制排尿功能的装置 - Google Patents

闭环超声刺激控制排尿功能的装置 Download PDF

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Publication number
WO2022109792A1
WO2022109792A1 PCT/CN2020/131180 CN2020131180W WO2022109792A1 WO 2022109792 A1 WO2022109792 A1 WO 2022109792A1 CN 2020131180 W CN2020131180 W CN 2020131180W WO 2022109792 A1 WO2022109792 A1 WO 2022109792A1
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Prior art keywords
module
ultrasonic
stimulation
ultrasonic stimulation
closed
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PCT/CN2020/131180
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English (en)
French (fr)
Inventor
牛丽丽
郑海荣
孟龙
邹俊杰
易沙沙
黄小伟
陈厚民基
钟永盛
周伟
Original Assignee
中国科学院深圳先进技术研究院
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Priority to PCT/CN2020/131180 priority Critical patent/WO2022109792A1/zh
Publication of WO2022109792A1 publication Critical patent/WO2022109792A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy

Definitions

  • the present application relates to the technical field of medical devices, and more particularly, to a device for controlling urination function by closed-loop ultrasonic stimulation.
  • neuromodulation technology is a cutting-edge technology that regulates nerve function by acting on nerve tissue through energy such as electricity, magnetism, light, sound and heat.
  • Ultrasound stimulation is a new generation of non-invasive and safe neuromodulation, and its effects on central and peripheral nerves have been extensively studied.
  • peripheral nerves with scattered locations and different depths, so it is difficult to achieve the treatment of different diseases with a universal ultrasonic stimulation tool.
  • the bladder is one of the most important organs of the human body. Cells are metabolized all the time, and the metabolites of the cells flow to the kidneys through the blood, and then the bilateral kidneys are processed and then flowed into the bladder. Finally, the bladder is responsible for passing the body's metabolites through the urine. Excretion out, the urination activity that the bladder participates in is of great significance.
  • the purpose of the embodiments of the present application is to provide a closed-loop ultrasonic stimulation device for controlling urination function, which aims to solve the problem that in the prior art, patients who have difficulty urinating use a catheter to conduct urine, and long-term catheterization is prone to urinary tract infection and affects the patient's urination function. technical issues.
  • a pressure sensing device comprising:
  • a closed-loop ultrasonic stimulation device for controlling urination function, comprising:
  • the imaging detection module is configured to image the bladder, obtain the imaging picture, and is configured to measure the urine volume value in the bladder;
  • an ultrasonic stimulation module configured to output ultrasonic nerve stimulation signals
  • control module is connected to the imaging detection module and the ultrasonic stimulation module respectively, and is configured to control the ultrasonic stimulation module to control the detection of all samples according to the imaging picture acquired by the imaging detection module and the acquired urine volume value.
  • the bladder outputs ultrasonic nerve stimulation signals.
  • the apparatus further includes a feedback module, the feedback module is connected with the imaging detection module and the control module, and the feedback module is configured to receive the real-time acquisition of the imaging detection module by the imaging detection module.
  • the ultrasonic stimulation module outputs the bladder imaging picture and urine volume value stimulated by the ultrasonic nerve stimulation signal, and sends the signal to the control module, and the control module controls the ultrasonic stimulation module to continue to output the ultrasonic nerve according to the signal sent by the feedback module. Stimulate the signal or stop outputting the ultrasonic nerve stimulation signal.
  • the apparatus further includes a fixed mobile module configured to be fixed on the abdomen of a patient, the fixed mobile module being connected to the ultrasound stimulation module and the control module, the control module being based on the imaging
  • the imaging picture acquired by the detection module controls the position of the ultrasonic stimulation module on the fixed moving module, and then adjusts the position of the ultrasonic stimulation module on the patient.
  • the ultrasonic stimulation module is arranged on the fixed moving module through a transmission device.
  • the device further includes a housing disposed outside the imaging detection module and the ultrasound stimulation module.
  • a signal transmission port is provided on the casing, and the signal transmission port is used for electrical connection with the terminal device.
  • the signal transmission port is connected with the terminal device in a wired manner or a wireless manner.
  • the imaging detection module includes:
  • an imaging unit for acquiring imaging pictures of the bladder
  • the calculation unit is used to obtain and calculate the urine volume value in the bladder.
  • the ultrasound stimulation module is a focused ultrasound transducer or a multi-array circular ultrasound transducer.
  • the imaging detection unit is a high frequency ultrasound transducer.
  • the fixed moving module is connected with the housing through the transmission device.
  • the fixed moving module is a fixed belt, and a wear-resistant material layer is provided on the fixed belt.
  • the device further includes a coupling layer disposed between the ultrasound stimulation module and the patient's skin.
  • the beneficial effect of the device for controlling urination function by closed-loop ultrasonic stimulation provided by the present application is that, compared with the prior art, the device for controlling urination function by closed-loop ultrasonic stimulation of the present application can be directly placed on the skin of the patient's lower abdomen, and detected by imaging.
  • the module obtains bladder imaging pictures and urine volume values
  • the control module controls the ultrasonic stimulation module to output ultrasonic nerve stimulation signals to the patient's bladder according to the imaging pictures and urine volume values obtained by the imaging detection module, so as to adjust the contraction function of the bladder and greatly reduce the current situation.
  • the examinee can move appropriately while being stimulated by ultrasound, which greatly increases the comfort of the examinee.
  • FIG. 1 is a schematic structural diagram of a device for controlling urination function by closed-loop ultrasonic stimulation provided by an embodiment of the present application;
  • FIG. 2 is a schematic diagram of a use state of a device for controlling urination function by closed-loop ultrasonic stimulation provided by an embodiment of the present application;
  • FIG. 3 is a schematic diagram of another use state of the device for controlling urination function by closed-loop ultrasonic stimulation provided by an embodiment of the present application to a patient;
  • FIG. 4 is a schematic diagram of the principle of a device for controlling urination function by closed-loop ultrasonic stimulation provided by an embodiment of the present application;
  • FIG. 5 is a schematic diagram of an imaging detection module of an apparatus for controlling urination function by closed-loop ultrasonic stimulation provided by an embodiment of the present application;
  • FIG. 6 is a schematic diagram of a signal principle of a device for closed-loop ultrasonic stimulation to control urination function provided by an embodiment of the present application;
  • FIG. 7 is a schematic diagram of a terminal device provided by an embodiment of the present application.
  • 1-imaging detection module 2-ultrasound stimulation module; 3-control module; 4-feedback module; 5-fixed moving module; 6-housing; 7-signal transmission port; 8-coupling layer;
  • the term “if” may be contextually interpreted as “when” or “once” or “in response to determining” or “in response to detecting” .
  • the phrases “if it is determined” or “if the [described condition or event] is detected” may be interpreted, depending on the context, to mean “once it is determined” or “in response to the determination” or “once the [described condition or event] is detected. ]” or “in response to detection of the [described condition or event]”.
  • the mobile terminals described in the embodiments of the present application include, but are not limited to, other portable devices such as mobile phones, laptop computers or tablet computers with touch-sensitive surfaces (eg, touch screen displays and/or touch pads).
  • other portable devices such as mobile phones, laptop computers or tablet computers with touch-sensitive surfaces (eg, touch screen displays and/or touch pads).
  • touch-sensitive surfaces eg, touch screen displays and/or touch pads.
  • the above-described devices are not portable communication devices, but rather desktop computers with touch-sensitive surfaces (eg, touch screen displays and/or touch pads).
  • a mobile terminal including a display and a touch-sensitive surface is described.
  • the mobile terminal may include one or more other physical user interface devices such as a physical keyboard, mouse and/or joystick.
  • the mobile terminal supports various applications such as one or more of the following: drawing application, presentation application, word processing application, website creation application, disc burning application, spreadsheet application, gaming application, telephone Apps, Video Conferencing Apps, Email Apps, Instant Messaging Apps, Workout Support Apps, Photo Management Apps, Digital Camera Apps, Digital Video Camera Apps, Web Browsing Apps, Digital Music Player Apps and/or digital video player applications.
  • Various applications that may be executed on the mobile terminal may use at least one common physical user interface device, such as a touch sensitive surface.
  • a touch sensitive surface One or more functions of the touch-sensitive surface and corresponding information displayed on the terminal may be adjusted and/or changed between applications and/or within respective applications.
  • the common physical architecture of the terminal eg, touch-sensitive surface
  • first and second are only used for descriptive purposes, and should not be construed as indicating or implying relative importance or implying the number of indicated technical features. Thus, a feature defined as “first” or “second” may expressly or implicitly include one or more of that feature.
  • plurality means two or more, unless otherwise expressly and specifically defined.
  • an embodiment of the present application provides a closed-loop ultrasonic stimulation device 100 for controlling urination function, including an imaging detection module 1 , an ultrasonic stimulation module 2 and a control module 3 , and the imaging detection module 1 is configured to
  • the bladder 300 performs imaging, acquires imaging pictures, and is configured to measure the urine volume value in the bladder 300;
  • the ultrasound stimulation module 2 is configured to output ultrasound nerve stimulation signals;
  • the control module 3 is respectively connected with the imaging detection module 1 and the ultrasound
  • the stimulation module 2 is connected and configured to control the ultrasonic stimulation module 2 to output an ultrasonic nerve stimulation signal to the bladder 300 according to the imaging picture obtained by the imaging detection module 1 and the obtained urine volume value.
  • the device for controlling the urination function by closed-loop ultrasonic stimulation provided by the embodiment of the present application can be directly placed on the skin of the lower abdomen of the patient, and the imaging detection module 1 obtains the imaging picture of the bladder 300 and the urine volume value, and the control module 3 is based on the imaging detection module 1.
  • the acquired imaging picture and the acquired urine volume value control the ultrasonic stimulation module 2 to output ultrasonic nerve stimulation signals to the patient's bladder 300, adjust the contraction function of the bladder 300, and greatly reduce the surgical implantation of electrodes or catheters in the prior art.
  • the examinee can move appropriately while the ultrasound is being stimulated, which greatly increases the comfort of the examinee.
  • the ultrasonic stimulation module 2 is an ultrasonic transducer, the ultrasonic transducer can output an ultrasonic nerve stimulation signal, and the working parameters of the ultrasonic nerve stimulation signal (for example, power, frequency and waveform, etc.) can be preset, And can be a variety of ultrasonic nerve stimulation signals.
  • an ultrasound transducer also referred to as an ultrasound probe
  • an ultrasound probe is an important part of medical ultrasound equipment, which can perform conversion between electrical and mechanical energy.
  • the device further includes a feedback module 4, the feedback module 4 is connected to the imaging detection module 1 and the control module 3, and the The feedback module 4 is configured to receive the imaging picture and urine volume value of the bladder 300 after being stimulated by the ultrasonic nerve stimulation signal output by the ultrasonic stimulation module 2 acquired in real time by the imaging detection module 1, and send the signal to the control module 3,
  • the control module 3 controls the ultrasound stimulation module 2 to continue outputting the ultrasound nerve stimulation signal or stop outputting the ultrasound nerve stimulation signal according to the signal sent by the feedback module 4 .
  • the real-time monitoring data of the imaging detection module 1 can be used to judge the effect of the ultrasonic stimulation through the feedback module 4, and the effect can be sent in a timely manner.
  • the control module 3 controls the ultrasound stimulation module 2 to continue outputting the ultrasound nerve stimulation signal or stop outputting the ultrasound nerve stimulation signal according to the transmission signal, and can also control the output frequency of the ultrasound stimulation module 2, and can observe the safety and reliability of ultrasound in real time. Stimulate the response, make the ultrasonic regulation more flexible, effective and safe, and ensure its safety and real-time.
  • the device further includes a fixed moving module 5 configured to be fixed on the abdomen of the patient, the fixed moving module 5 and the ultrasonic stimulation module 2 is connected with the control module 3, the control module 3 controls the position of the ultrasonic stimulation module 2 in the fixed moving module 5 according to the imaging picture obtained by the imaging detection module 1, and then adjusts the position of the ultrasonic stimulation module 2 in the fixed moving module 5; position on the patient.
  • a fixed moving module 5 configured to be fixed on the abdomen of the patient
  • the fixed moving module 5 and the ultrasonic stimulation module 2 is connected with the control module 3
  • the control module 3 controls the position of the ultrasonic stimulation module 2 in the fixed moving module 5 according to the imaging picture obtained by the imaging detection module 1, and then adjusts the position of the ultrasonic stimulation module 2 in the fixed moving module 5; position on the patient.
  • the ultrasonic stimulation module 2 is arranged on the fixed moving module 5 through a transmission device.
  • the fixed moving module 5 is a fixed belt, and a wear-resistant material layer is provided on the fixed belt.
  • the device is fixed on the lower abdomen of the patient by fixing the moving module 5, and then the bladder 300 is imaged by the imaging detection module 1, so that the target position can be accurately located, and the position of the bladder 300 can be identified non-invasively and quickly.
  • the position of the ultrasonic stimulation module 2 that is, the position of the ultrasonic stimulation module 2 on the fixed belt can be adjusted to accurately correspond to the position of the patient's bladder 300
  • the transmission device can be the bearing transmission mode in the prior art , it can also be a chain transmission mode, or it can be other transmission modes in the prior art, which will not be repeated here.
  • the device further includes a housing 6 disposed outside the imaging detection module 1 and the ultrasonic stimulation module 2 .
  • the shell 6 can choose resin, plastic and peek (Peek materials, polyetheretherketone) and other materials with good histocompatibility, but not limited to other materials such as metals.
  • the fixed moving module 5 is connected with the housing 6 through the transmission device.
  • the fixed belt can be connected to the casing 6 through a transmission device, which is convenient to adjust the position of the ultrasonic stimulation module 2 inside the casing 6 on the lower abdomen of the patient.
  • the transmission device can be a bearing transmission method in the prior art, or a chain type
  • the transmission mode may also be other transmission modes in the prior art, which will not be repeated here.
  • the casing 6 is provided with a signal transmission port 7 , and the signal transmission port 7 is used for electrical connection with the terminal device.
  • the signal transmission port 7 is connected with the terminal device in a wired or wireless manner.
  • the ultrasound imaging data of the imaging detection module 1 can be transmitted to the computer operation terminal, which is convenient for technicians and doctors to judge the condition of the patient's bladder 300 and urinary tract through the image.
  • the preset ultrasonic parameters can be transmitted to the ultrasonic transducer (ultrasonic stimulation module 2 ) through the signal transmission port 7 .
  • control module 3 can be optionally integrated into the device and run in the form of a chip, but considering the cost requirement, the processor can be set outside and transmit signals through the signal transmission port 7 .
  • the imaging detection module 1 includes: an imaging unit 101 for acquiring an imaging picture of the bladder 300 ; a computing unit 102 for acquiring and calculating the urine output value. and transmit the acquired imaging picture and urine volume value to the control module 3 and the feedback module 4, specifically, the imaging ultrasonic transducer, through the ultrasonic scattered waves emitted by the imaging ultrasonic transducer, can penetrate human skin and other The tissue reaches a certain depth, observe the reflected signal to observe the position of the bladder 300, and by collecting the echo of the water signal in the bladder 300, determine the urine volume in the bladder 300, and send the above data to the control module 3, and the control module 3 according to the The data is controlled and the ultrasonic stimulation module 2 outputs the ultrasonic nerve stimulation signal.
  • the ultrasonic stimulation module 2 is a focused ultrasonic transducer or a multi-array circular ultrasonic transducer. According to the needs of research and treatment, ultrasonic transducers with different frequencies, different focusing effects, different output energies, and different focal spot sizes and focal lengths can be selected. Preferably, a low-intensity focused ultrasonic transducer with a fundamental frequency of 200kHz-4MHz is used. But not limited to the above parameters. On the ultrasonic transducer material, it is preferably a magnetically compatible material, but is not limited to other materials.
  • the ultrasonic stimulation module 2 is also an ultrasonic transducer. According to the needs of research and treatment, ultrasonic transducers with different array elements can be selected. Individually commanded to emit ultrasound from different directions, ultimately reaching the depth of the target area.
  • the ultrasonic stimulation module 2 is also an ultrasonic transducer. According to the needs of research and treatment, it is preferable to select a detachable ultrasonic transducer.
  • the ultrasonic transducer can be disassembled in the housing 6, so that the needs to be replaced, but an integrated ultrasound transducer can also be used.
  • the imaging detection unit is a high frequency ultrasonic transducer. According to the needs of research and treatment, ultrasonic transducers of different sizes and materials can be selected. The high-frequency ultrasound transducer commonly used in clinic is preferred.
  • the device further includes a coupling layer 8 , and the coupling layer 8 is disposed between the ultrasonic stimulation module 2 and the skin of the patient.
  • the coupling layer 8 is disposed in the gap between the ultrasonic transducer and the skin, and the coupling layer 8 can be filled with a solid or liquid coupling material, so that the ultrasonic energy can better reach the target area.
  • the device for controlling the urination function by closed-loop ultrasonic stimulation of the present application can be directly placed on the skin of the lower abdomen of the patient, and the imaging detection module 1 obtains the imaging picture of the bladder 300 and the urine volume value, and the control module 3 is based on the imaging detection module.
  • the acquired imaging pictures and the acquired urine volume value control the ultrasonic stimulation module 2.
  • ultrasound can be applied directly to the skin of the lower abdomen, which greatly reduces the adverse reactions associated with surgical implantation of electrical implants.
  • the target position can be accurately positioned, the position of the bladder 300 can be identified non-invasively and quickly, and the ultrasound can be guided to regulate the function of the bladder 300 .
  • the device for controlling urination function by closed-loop ultrasonic stimulation provided by the present application can receive treatment of other parts during ultrasonic stimulation, and the examinee can move appropriately while the ultrasonic stimulation is performed, which greatly increases the comfort of the examinee.
  • the present application is provided with a feedback module 4, which can observe the safety and stimulation response of ultrasound in real time, making ultrasound regulation more flexible, effective and safe.
  • the terminal device 200 may be a computing device such as a desktop computer, a notebook computer, a palmtop computer, and a cloud server.
  • the terminal device may include, but is not limited to, the processor 201 and the memory 202 .
  • FIG. 7 is only an example of the terminal device 200, and does not constitute a limitation on the terminal device 200. It may include more or less components than the one shown, or combine some components, or different components
  • the terminal device may further include an input and output device, a network access device, a bus, and the like.
  • the so-called processor 201 may be a central processing unit (Central Processing Unit, CPU), and may also be other general-purpose processors, digital signal processors (Digital Signal Processors, DSP), application specific integrated circuits (Application Specific Integrated Circuit, ASIC), Field-Programmable Gate Array (FPGA) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc.
  • a general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.
  • the memory 202 may be an internal storage unit of the terminal device 200 , such as a hard disk or a memory of the terminal device 200 .
  • the memory 202 may also be an external storage device of the terminal device 200, for example, a plug-in hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) equipped on the terminal device 200 card, Flash Card, etc.
  • the memory 202 may also include both an internal storage unit of the terminal device 200 and an external storage device.
  • the memory 202 is used for storing the computer program and other programs and data required by the terminal device.
  • the memory 202 may also be used to temporarily store data that has been output or is to be output.
  • the disclosed apparatus/terminal device and method may be implemented in other manners.
  • the apparatus/terminal device embodiments described above are only illustrative.
  • the division of the modules or units is only a logical function division. In actual implementation, there may be other division methods, such as multiple units. Or components may be combined or may be integrated into another system, or some features may be omitted, or not implemented.
  • the shown or discussed mutual coupling or direct coupling or communication connection may be through some interfaces, indirect coupling or communication connection of devices or units, and may be in electrical, mechanical or other forms.
  • the units described as separate components may or may not be physically separated, and components displayed as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution in this embodiment.
  • each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically alone, or two or more units may be integrated into one unit.
  • the above-mentioned integrated units may be implemented in the form of hardware, or may be implemented in the form of software functional units.
  • the integrated modules/units if implemented in the form of software functional units and sold or used as independent products, may be stored in a computer-readable storage medium.
  • the present application can implement all or part of the processes in the methods of the above embodiments, and can also be completed by instructing the relevant hardware through the computer program 203, and the computer program can be stored in a computer-readable storage medium, the When the computer program is executed by the processor, the steps of the above method embodiments can be implemented.
  • the computer program includes computer program code, and the computer program code may be in the form of source code, object code, executable file or some intermediate form, and the like.
  • the computer-readable medium may include: any entity or device capable of carrying the computer program code, recording medium, U disk, removable hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM, Read-Only Memory) , Random Access Memory (RAM, Random Access Memory), electric carrier signal, telecommunication signal and software distribution medium, etc. It should be noted that the content contained in the computer-readable media may be appropriately increased or decreased according to the requirements of legislation and patent practice in the jurisdiction, for example, in some jurisdictions, according to legislation and patent practice, the computer-readable media Electric carrier signals and telecommunication signals are not included.

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Abstract

本申请公开一种闭环超声刺激控制排尿功能的装置（100），适用于医疗器械技术领域，该装置（100）中成像检测模块（1）被配置为对膀胱（300）获取成像图片，且被配置为测量膀胱（300）中尿量值；超声刺激模块（2）被配置为输出超声神经刺激信号；控制模块（3）被配置为根据成像检测模块（1）获取的成像图片和获取的尿量值，控制超声刺激模块（2）对膀胱输出超声神经刺激信号。本申请的装置，可直接放在患者的下腹部皮肤上，通过成像检测模块（1）获取膀胱（300）成像图片和尿量值，控制模块（3）根据其成像图片和尿量值控制超声刺激模块（3）对患者的膀胱进行输出超声神经刺激信号，调节膀胱（300）的收缩功能，提高了被检查者的舒适性。

Description

闭环超声刺激控制排尿功能的装置 技术领域
本申请涉及医疗器械技术领域，更具体地说，是涉及一种闭环超声刺激控制排尿功能的装置。
 背景技术
目前，神经调控技术是通过电、磁、光、声和热等能量作用于神经组织中，调节神经功能的前沿技术。超声刺激是新一代无创的、安全的神经调控方式，其对中枢及外周神经的作用己经得到广泛的研究。但是，外周神经种类繁多，位置分散，深浅不一，难以通过通用的超声刺激工具实现对不同疾病的治疗。
膀胱是人体重要的器官之一，细胞无时无刻都在进行代谢，而细胞的代谢产物通过血液流到肾脏，然后双侧肾脏进行处理后汇入膀胱，最后，膀胱负责将人体的代谢产物通过尿液排泄出去，膀胱参与的排尿活动有着重要的意义。
在临床中，多种神经源性疾病会影响着膀胱的功能，由于神经功能衰弱，使膀胱排尿的功能受到严重影响，例如，神经源性膀胱无力导致的尿潴留；还有孕妇产后也容易产生尿潴留的现像。对于尿潴留患者，临床常用的方法是通过导尿管导出尿液，但是导尿会容易损伤尿路，同时，长期导尿容易发生尿道感染，对于长期卧床或者体质虚弱的患者，这会引起一系列其它并发症，有可能影响患者的生命健康。此外，对于一些需要排尿训练的患者，需要在尿液积累到一定量的时候提醒患者排尿，而导尿管的长期使用，则会使该部分患者的排尿功能进一步下降，影响患者的健康安全。
 技术问题
本申请实施例的目的在于提供一种闭环超声刺激控制排尿功能的装置，旨在解决现有技术中对排尿困难的患者采用导尿管导尿，长期导尿容易发生尿道感染及影响患者排尿功能的技术问题。
 技术解决方案
为解决上述技术问题，本申请实施例采用的技术方案是：
第一方面，提供了一种压力感应装置，包括：
提供一种闭环超声刺激控制排尿功能的装置，包括：
成像检测模块，被配置为对膀胱进行成像，并获取成像图片，且被配置为测量膀胱中尿量值；
超声刺激模块，被配置为输出超声神经刺激信号；
控制模块，所述控制模块分别与所述成像检测模块和超声刺激模块连接，被配置为根据所述成像检测模块获取的成像图片和获取的所述尿量值，控制所述超声刺激模块对所述膀胱输出超声神经刺激信号。
在一个实施例中，所述装置还包括反馈模块，所述反馈模块与所述成像检测模块和所述控制模块连接，所述反馈模块被配置为接收所述成像检测模块实时获取的被所述超声刺激模块输出超声神经刺激信号刺激后的膀胱成像图片和尿量值，并发送信号至所述控制模块，所述控制模块根据所述反馈模块的发送信号控制所述超声刺激模块继续输出超声神经刺激信号或停止输出超声神经刺激信号。
在一个实施例中，所述装置还包括固定移动模块，被配置为固定在患者的腹部，所述固定移动模块与所述超声刺激模块和所述控制模块连接，所述控制模块根据所述成像检测模块获取的成像图片，控制所述超声刺激模块在固定移动模块的位置，进而调整所述超声刺激模块在患者身上的位置。
在一个实施例中，所述超声刺激模块通过传动装置设置于所述固定移动模块上。
在一个实施例中，所述装置还包括设置于所述成像检测模块和超声刺激模块外侧的壳体。
在一个实施例中，所述壳体上设置有信号传输端口，所述信号传输端口用于与终端设备电连接。
在一个实施例中，所述信号传输端口通过有线方式或无线方式与所述终端设备连接。
在一个实施例中，
所述成像检测模块包括：
成像单元，用于获取膀胱的成像图片；
计算单元，用于获取计算膀胱中的尿量值。
在一个实施例中，所述超声刺激模块为聚焦超声换能器或多阵圆超声换能器。
在一个实施例中，所述成像检测单元为高频超声换能器。
在一个实施例中，所述固定移动模块与所述壳体通过所述传动装置连接。
在一个实施例中，所述固定移动模块为固定带，所述固定带上设置有耐磨材料层。
在一个实施例中，所述装置还包括耦合层，所述耦合层设置于所述超声刺激模块与患者的皮肤之间。
 有益效果
本申请提供的闭环超声刺激控制排尿功能的装置的有益效果在于：与现有技术相比，本申请的闭环超声刺激控制排尿功能的装置，可以直接放置在患者的下腹部皮肤上，通过成像检测模块获取膀胱成像图片和尿量值，控制模块根据成像检测模块获取的成像图片和获取的尿量值控制超声刺激模块对患者的膀胱进行输出超声神经刺激信号，调节膀胱的收缩功能，大大减少现有技术中通过手术植入电极或导尿管的相关的不良反应，被检查者在超声刺激同时可以适当的活动，大大地增加了被检查者的舒适性。
 附图说明
图1是本申请的一个实施例提供的闭环超声刺激控制排尿功能的装置的结构示意图；
图2是本申请的一个实施例提供的闭环超声刺激控制排尿功能的装置对患者的一种使用状态示意图；
图3是本申请的一个实施例提供的闭环超声刺激控制排尿功能的装置对患者的另一种使用状态示意图；
图4是本申请的一个实施例提供的闭环超声刺激控制排尿功能的装置的原理示意图；
图5是本申请的一个实施例提供的闭环超声刺激控制排尿功能的装置的成像检测模块的原理示意图；
图6是本申请的一个实施例提供的闭环超声刺激控制排尿功能的装置的信号原理示意图；
图7是本申请实施例提供的终端设备的示意图。
上述附图所涉及的标号明细如下：
100-闭环超声刺激控制排尿功能的装置；
1-成像检测模块；2-超声刺激模块；3-控制模块；4-反馈模块；5-固定移动模块；6-壳体；7-信号传输端口；8-耦合层；
101-成像单元；102-计算单元；
200-终端设备；201-处理器；202-存储器；203-计算机程序；
300-膀胱。
 本发明的实施方式
为了使本申请所要解决的技术问题、技术方案及有益效果更加清楚明白，以下结合附图及实施例，对本申请进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本申请，并不用于限定本申请。
需要说明的是，当元件被称为“固定于”或“设置于”另一个元件，它可以直接在另一个元件上或者间接在该另一个元件上。当一个元件被称为是“连接于”另一个元件，它可以是直接连接到另一个元件或间接连接至该另一个元件上。
应当理解，当在本说明书和所附权利要求书中使用时，术语“包括”指示所描述特征、整体、步骤、操作、元素和/或组件的存在，但并不排除一个或多个其它特征、整体、步骤、操作、元素、组件和/或其集合的存在或添加。
还应当理解，在此本申请说明书中所使用的术语仅仅是出于描述特定实施例的目的而并不意在限制本申请。如在本申请说明书和所附权利要求书中所使用的那样，除非上下文清楚地指明其它情况，否则单数形式的“一”、“一个”及“该”意在包括复数形式。
还应当进一步理解，在本申请说明书和所附权利要求书中使用的术语“和/或”是指相关联列出的项中的一个或多个的任何组合以及所有可能组合，并且包括这些组合。
如在本说明书和所附权利要求书中所使用的那样，术语“如果”可以依据上下文被解释为“当...时”或“一旦”或“响应于确定”或“响应于检测到”。类似地，短语“如果确定”或“如果检测到[所描述条件或事件]”可以依据上下文被解释为意指“一旦确定”或“响应于确定”或“一旦检测到[所描述条件或事件]”或“响应于检测到[所描述条件或事件]”。
具体实现中，本申请实施例中描述的移动终端包括但不限于诸如具有触摸敏感表面(例如，触摸屏显示器和/或触摸板)的移动电话、膝上型计算机或平板计算机之类的其它便携式设备。还应当理解的是，在某些实施例中，上述设备并非便携式通信设备，而是具有触摸敏感表面(例如，触摸屏显示器和/或触摸板)的台式计算机。
在接下来的讨论中，描述了包括显示器和触摸敏感表面的移动终端。然而，应当理解的是，移动终端可以包括诸如物理键盘、鼠标和/或控制杆的一个或多个其它物理用户接口设备。
移动终端支持各种应用程序，例如以下中的一个或多个：绘图应用程序、演示应用程序、文字处理应用程序、网站创建应用程序、盘刻录应用程序、电子表格应用程序、游戏应用程序、电话应用程序、视频会议应用程序、电子邮件应用程序、即时消息收发应用程序、锻炼支持应用程序、照片管理应用程序、数码相机应用程序、数字摄影机应用程序、web浏览应用程序、数字音乐播放器应用程序和/或数字视频播放器应用程序。
可以在移动终端上执行的各种应用程序可以使用诸如触摸敏感表面的至少一个公共物理用户接口设备。可以在应用程序之间和/或相应应用程序内调整和/或改变触摸敏感表面的一个或多个功能以及终端上显示的相应信息。这样，终端的公共物理架构(例如，触摸敏感表面)可以支持具有对用户而言直观且透明的用户界面的各种应用程序。
此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。在本申请的描述中，“多个”的含义是两个或两个以上，除非另有明确具体的限定。
为了说明本申请所述的技术方案，以下结合具体附图及实施例进行详细说明。
如图1至图6所示，本申请的一个实施例提供了闭环超声刺激控制排尿功能的装置100，包括成像检测模块1、超声刺激模块2和控制模块3，成像检测模块1被配置为对膀胱300进行成像，并获取成像图片，且被配置为测量膀胱300中尿量值；超声刺激模块2被配置为输出超声神经刺激信号；所述控制模块3分别与所述成像检测模块1和超声刺激模块2连接，被配置为根据所述成像检测模块1获取的成像图片和获取的所述尿量值，控制所述超声刺激模块2对所述膀胱300输出超声神经刺激信号。
本申请的实施例提供的闭环超声刺激控制排尿功能的装置，可以直接放置在患者的下腹部皮肤上，通过成像检测模块1获取膀胱300成像图片和尿量值，控制模块3根据成像检测模块1获取的成像图片和获取的尿量值控制超声刺激模块2对患者的膀胱300进行输出超声神经刺激信号，调节膀胱300的收缩功能，大大减少现有技术中通过手术植入电极或导尿管的相关的不良反应，被检查者在超声刺激同时可以适当的活动，大大地增加了被检查者的舒适性。
需要说明的是，超声刺激模块2为超声换能器，超声换能器可以输出超声神经刺激信号，超声神经刺激信号的工作参数(例如，功率、频率和波形等)可以是预先设定的，并可以是多样化的超声神经刺激信号。应理解的是，超声换能器(也被称为，超声探头)是医学超声仪器设备的重要组成部分，其能完成在电能与机械能之间转换。
在本申请的上述实施例中，可选地，如图4所示，所述装置还包括反馈模块4，所述反馈模块4与所述成像检测模块1和所述控制模块3连接，所述反馈模块4被配置为接收所述成像检测模块1实时获取的被所述超声刺激模块2输出超声神经刺激信号刺激后的膀胱300成像图片和尿量值，并发送信号至所述控制模块3，所述控制模块3根据所述反馈模块4的发送信号控制所述超声刺激模块2继续输出超声神经刺激信号或停止输出超声神经刺激信号。
在该实施例中，在通过超声刺激模块2对膀胱300输出超声神经刺激信号后，通过成像检测模块1的实时监测数据，可通过反馈模块4判断超声刺激的作用效果，将该效果及时发送信号至控制模块3，控制模块3根据该发送信号控制超声刺激模块2继续输出超声神经刺激信号或停止输出超声神经刺激信号，也可以控制超声刺激模块2的输出频率，可以实时观察超声的安全性及刺激反应，使超声调控更加灵活、有效和安全，保证其安全和实时性。
在本申请的一些实施例中，可选地，如图3所示，所述装置还包括固定移动模块5，被配置为固定在患者的腹部，所述固定移动模块5与所述超声刺激模块2和所述控制模块3连接，所述控制模块3根据所述成像检测模块1获取的成像图片，控制所述超声刺激模块2在固定移动模块5的位置，进而调整所述超声刺激模块2在患者身上的位置。
可选地，所述超声刺激模块2通过传动装置设置于所述固定移动模块5上。
进一步地，所述固定移动模块5为固定带，所述固定带上设置有耐磨材料层。
在该实施例中，通过固定移动模块5将该装置固定在患者的下腹部上，进而通过成像检测模块1对膀胱300的成像，可以准确地定位目标位置，无创、快速得识别膀胱300的位置，进而调整超声刺激模块2的位置，也就是可以调整超声刺激模块2在固定带上的位置，使其准确地对应患者膀胱300的位置，其中，传动装置可以是现有技术中的轴承传动方式，也可以是链式传动方式，也可以是现有技术其他的传动方式，在此就不一一赘述。
在本申请的一些实施例中，可选地，如图1所示，所述装置还包括设置于所述成像检测模块1和超声刺激模块2外侧的壳体6。
在该实施例中，通过壳体6的设置，可以对壳体6内部的各个模块起到保护作用和散热作用，使成像检测模块1和超声刺激检测模块正常运行。另外，壳体6可以选用树脂、塑料及peek（     Peek materials，聚醚醚酮）等组织相容性好的材料，但不限于如金属等其它材料。
可选地，所述固定移动模块5与所述壳体6通过所述传动装置连接。固定带可以通过传动装置与壳体6传动连接，方便调整壳体6内部超声刺激模块2在患者下腹部的位置，其中，传动装置可以是现有技术中的轴承传动方式，也可以是链式传动方式，也可以是现有技术其他的传动方式，在此就不一一赘述。
在本申请的上述实施例中，可选地，如图1和图6所示，所述壳体6上设置有信号传输端口7，所述信号传输端口7用于与终端设备电连接。
进一步地，所述信号传输端口7通过有线方式或无线方式与所述终端设备连接。
在该实施例中，通过信号传输端口7，可以将成像检测模块1的超声成像的数据传送到电脑操作端，方便技术人员及医生通过图像判断患者膀胱300及尿路情况。并可以通过该信号传输端口7，将预设的超声参数传送到超声换能器（超声刺激模块2）中。
需要说明的是，控制模块3可选择集成与装置之中，以芯片的形式进运行，但考虑到成本需要，可以将处理器设置在外部，通过信号传输端口7传送信号。
在本申请的一些实施例中，可选地，如图5所示，所述成像检测模块1包括：成像单元101用于获取膀胱300的成像图片；计算单元102用于获取计算膀胱300中的尿量值。并将获取的成像图片和尿量值传输到控制模块3和反馈模块4中，具体地，成像超声换能器，通过成像超声换能器发射出的超声散射波，可以穿透人体皮肤及其它组织到达一定深度，观察反射的信号观察到膀胱300的位置，并通过收集膀胱300内水信号的回声，判断膀胱300内的尿量，并将上述数据发送至控制模块3，控制模块3根据该数据进行控制超声刺激模块2输出超声神经刺激信号。
可选地地，所述超声刺激模块2为聚焦超声换能器或多阵圆超声换能器。根据研究与治疗需要，可以选择不同频率、不同聚焦效果，不同输出能量和不同焦斑大小和焦距的超声换能器，优选的，使用基频为200kHz-4MHz的低强度聚焦超声换能器，但不限于上述的参数。在超声换能器材料上，优选为磁兼容材料，但不限于选择其它材料。
可选地，超声刺激模块2也就是超声换能器，根据研究和治疗的需要，可以选择不同阵元的超声换能器，优选的是多阵元可调节换能器，每个阵元可以单独接受指令，从不同的方向发射超声，最终达到目标区域的深度。
可选地，超声刺激模块2也就是超声换能器，根据研究和治疗的需要，优选得选择可拆卸的超声换能器，超声换能器可以在壳体6内进行拆卸，这样可以根据治疗的需要进行更换，但也可以使用集成的超声换能器。
进一步地，所述成像检测单元为高频超声换能器。根据研究与治疗需要，可以选择不同大小，不同材料的超声换能器。优选临床上常用的高频超声换能器。
在本申请的一些实施例中，可选地，如图2所示，所述装置还包括耦合层8，所述耦合层8设置于所述超声刺激模块2与患者的皮肤之间。
在该实施例中，耦合层8设置于超声换能器与皮肤之间的间隙，耦合层8可以选择固体或液体的耦合材料制成填充，使超声波能更好地达到目标区域。
综上所述，本申请的闭环超声刺激控制排尿功能的装置，可以直接放置在患者的下腹部皮肤上，通过成像检测模块1获取膀胱300成像图片和尿量值，控制模块3根据成像检测模块1获取的成像图片和获取的尿量值控制超声刺激模块2对患者的膀胱300进行输出超声神经刺激信号，调节膀胱300的收缩功能，大大减少现有技术中通过手术植入电极或导尿管的相关的不良反应，被检查者在超声刺激同时可以适当的活动，大大地增加了被检查者的舒适性。具备无创，安全，准确、满足个性化操作及治疗的需求。由于超声刺激的无创性，超声能直接应用在下腹部皮肤上，大大减少与手术植入电及的相关的不良反应。通过超声成像，可以准确定位于目标位置，无创、快速得识别膀胱300的位置，引导超声调控膀胱300的功能。本申请的提供的闭环超声刺激控制排尿功能的装置能在超声刺激的同时，接受其它部位治疗，并且被检查者在超声刺激同时可以适当的活动，大大地增加了被检查者的舒适性。另外，本申请中带有反馈模块4，可以实时观察超声的安全性及刺激反应，使超声调控更加灵活、有效和安全。
需要说明的是，如图7所示，所述终端设备200可以是桌上型计算机、笔记本、掌上电脑及云端服务器等计算设备。所述终端设备可包括，但不仅限于，处理器201、存储器202。本领域技术人员可以理解，图7仅仅是终端设备200的示例，并不构成对终端设备200的限定，可以包括比图示更多或更少的部件，或者组合某些部件，或者不同的部件，例如所述终端设备还可以包括输入输出设备、网络接入设备、总线等。
所称处理器201可以是中央处理单元(Central Processing Unit，CPU)，还可以是其他通用处理器、数字信号处理器 (Digital Signal Processor，DSP)、专用集成电路 (Application Specific Integrated Circuit，ASIC)、现场可编程门阵列 (Field-Programmable Gate Array，FPGA) 或者其他可编程逻辑器件、分立门或者晶体管逻辑器件、分立硬件组件等。通用处理器可以是微处理器或者该处理器也可以是任何常规的处理器等。
所述存储器202可以是所述终端设备200的内部存储单元，例如终端设备200的硬盘或内存。所述存储器202也可以是所述终端设备200的外部存储设备，例如所述终端设备200上配备的插接式硬盘，智能存储卡（Smart Media Card, SMC），安全数字（Secure Digital, SD）卡，闪存卡（Flash Card）等。进一步地，所述存储器202还可以既包括所述终端设备200的内部存储单元也包括外部存储设备。所述存储器202用于存储所述计算机程序以及所述终端设备所需的其他程序和数据。所述存储器202还可以用于暂时地存储已经输出或者将要输出的数据。
所属领域的技术人员可以清楚地了解到，为了描述的方便和简洁，仅以上述各功能单元、模块的划分进行举例说明，实际应用中，可以根据需要而将上述功能分配由不同的功能单元、模块完成，即将所述装置的内部结构划分成不同的功能单元或模块，以完成以上描述的全部或者部分功能。实施例中的各功能单元、模块可以集成在一个处理单元中，也可以是各个单元单独物理存在，也可以两个或两个以上单元集成在一个单元中，上述集成的单元既可以采用硬件的形式实现，也可以采用软件功能单元的形式实现。另外，各功能单元、模块的具体名称也只是为了便于相互区分，并不用于限制本申请的保护范围。上述系统中单元、模块的具体工作过程，可以参考前述方法实施例中的对应过程，在此不再赘述。
在上述实施例中，对各个实施例的描述都各有侧重，某个实施例中没有详述或记载的部分，可以参见其它实施例的相关描述。
本领域普通技术人员可以意识到，结合本文中所公开的实施例描述的各示例的单元及算法步骤，能够以电子硬件、或者计算机软件和电子硬件的结合来实现。这些功能究竟以硬件还是软件方式来执行，取决于技术方案的特定应用和设计约束条件。专业技术人员可以对每个特定的应用来使用不同方法来实现所描述的功能，但是这种实现不应认为超出本申请的范围。
在本申请所提供的实施例中，应该理解到，所揭露的装置/终端设备和方法，可以通过其它的方式实现。例如，以上所描述的装置/终端设备实施例仅仅是示意性的，例如，所述模块或单元的划分，仅仅为一种逻辑功能划分，实际实现时可以有另外的划分方式，例如多个单元或组件可以结合或者可以集成到另一个系统，或一些特征可以忽略，或不执行。另一点，所显示或讨论的相互之间的耦合或直接耦合或通讯连接可以是通过一些接口，装置或单元的间接耦合或通讯连接，可以是电性，机械或其它的形式。
所述作为分离部件说明的单元可以是或者也可以不是物理上分开的，作为单元显示的部件可以是或者也可以不是物理单元，即可以位于一个地方，或者也可以分布到多个网络单元上。可以根据实际的需要选择其中的部分或者全部单元来实现本实施例方案的目的。
另外，在本申请各个实施例中的各功能单元可以集成在一个处理单元中，也可以是各个单元单独物理存在，也可以两个或两个以上单元集成在一个单元中。上述集成的单元既可以采用硬件的形式实现，也可以采用软件功能单元的形式实现。
所述集成的模块/单元如果以软件功能单元的形式实现并作为独立的产品销售或使用时，可以存储在一个计算机可读取存储介质中。基于这样的理解，本申请实现上述实施例方法中的全部或部分流程，也可以通过计算机程序203来指令相关的硬件来完成，所述的计算机程序可存储于一计算机可读存储介质中，该计算机程序在被处理器执行时，可实现上述各个方法实施例的步骤。其中，所述计算机程序包括计算机程序代码，所述计算机程序代码可以为源代码形式、对象代码形式、可执行文件或某些中间形式等。所述计算机可读介质可以包括：能够携带所述计算机程序代码的任何实体或装置、记录介质、U盘、移动硬盘、磁碟、光盘、计算机存储器、只读存储器（ROM，Read-Only Memory）、随机存取存储器（RAM，Random Access Memory）、电载波信号、电信信号以及软件分发介质等。需要说明的是，所述计算机可读介质包含的内容可以根据司法管辖区内立法和专利实践的要求进行适当的增减，例如在某些司法管辖区，根据立法和专利实践，计算机可读介质不包括电载波信号和电信信号。
以上所述仅为本申请的可选实施例而已，并不用以限制本申请，凡在本申请的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本申请的保护范围之内。

Claims (13)

  1. 一种闭环超声刺激控制排尿功能的装置，其特征在于，包括：
    成像检测模块，被配置为对膀胱进行成像，并获取成像图片，且被配置为测量膀胱中尿量值；
    超声刺激模块，被配置为输出超声神经刺激信号；
    控制模块，所述控制模块分别与所述成像检测模块和超声刺激模块连接，被配置为根据所述成像检测模块获取的成像图片和获取的所述尿量值，控制所述超声刺激模块对所述膀胱输出超声神经刺激信号。
  2. 如权利要求1所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述装置还包括反馈模块，所述反馈模块与所述成像检测模块和所述控制模块连接，所述反馈模块被配置为接收所述成像检测模块实时获取的被所述超声刺激模块输出超声神经刺激信号刺激后的膀胱成像图片和尿量值，并发送信号至所述控制模块，所述控制模块根据所述反馈模块的发送信号控制所述超声刺激模块继续输出超声神经刺激信号或停止输出超声神经刺激信号。
  3. 如权利要求1所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述装置还包括固定移动模块，被配置为固定在患者的腹部，所述固定移动模块与所述超声刺激模块和所述控制模块连接，所述控制模块根据所述成像检测模块获取的成像图片，控制所述超声刺激模块在固定移动模块的位置，进而调整所述超声刺激模块在患者身上的位置。
  4. 如权利要求3所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述超声刺激模块通过传动装置设置于所述固定移动模块上。
  5. 如权利要求4所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述装置还包括设置于所述成像检测模块和超声刺激模块外侧的壳体。
  6. 如权利要求5所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述壳体上设置有信号传输端口，所述信号传输端口用于与终端设备电连接。
  7. 如权利要求6所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述信号传输端口通过有线方式或无线方式与所述终端设备连接。
  8. 如权利要求1所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述成像检测模块包括：
    成像单元，用于获取膀胱的成像图片；
    计算单元，用于获取计算膀胱中的尿量值。
  9. 如权利要求1所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述超声刺激模块为聚焦超声换能器或多阵圆超声换能器。
  10. 如权利要求1所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述成像检测单元为高频超声换能器。
  11. 如权利要求1所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述固定移动模块与所述壳体通过所述传动装置连接。
  12. 如权利要求11所述的闭环超声刺激控制排尿功能的装置，其特征在于，所述固定移动模块为固定带，所述固定带上设置有耐磨材料层。
  13. 如权利要求1所述的闭环超声刺激控制排尿功能的装置，所述装置还包括耦合层，所述耦合层设置于所述超声刺激模块与患者的皮肤之间。
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CN102307618A (zh) * 2008-12-09 2012-01-04 内费拉有限公司 泌尿系统的刺激
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CN102307618A (zh) * 2008-12-09 2012-01-04 内费拉有限公司 泌尿系统的刺激
CN103611218A (zh) * 2013-10-25 2014-03-05 中国医学科学院生物医学工程研究所 超声三维影像引导的膀胱自主排尿系统
CN107949421A (zh) * 2015-05-21 2018-04-20 多伦多大学管理委员会 用于治疗泌尿功能障碍的系统和方法
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