WO2022107101A1

WO2022107101A1 - Bovine integrator

Info

Publication number: WO2022107101A1
Application number: PCT/IB2021/060851
Authority: WO
Inventors: Guglielmo Buonamici
Original assignee: Food For Future S.r.l. Societa' Benefit
Priority date: 2020-11-23
Filing date: 2021-11-23
Publication date: 2022-05-27

Abstract

It is provided a bovine supplement characterized by extracts of Galega officinalis, Trifolium pratense, Silybum marianum, Moringa oleifera, Cnicus benedictus Gaertner, Carum carvi, lllicium anisatum, Foeniculum officinale, Pimpinella anisum, Urtica dioica eTrigonella foenum graecum.

Description

DESCRIPTION

BOVINE INTEGRATOR

The present invention relates to a bovine supplement, i.e. a food supplement for dairy cattle, of the type specified in the preamble of the first claim.

As is known about the zootechnical problems, with regard to the milk character, the feeding of dairy cattle plays a role of primary importance (it has been ascertained that it affects the manifestation of the milk character for about 90%).

Many studies have brought to light how the purchase of food of high genetic value is a waste if these animals are not placed in the best breeding conditions and in particular, if not subjected to a correct diet, not only in terms of the quantity of food to be administered, but also as their chemical composition.

Food errors affect not only productivity but also the health of the animals reared and consequently the business economy.

In fact, apart from the damage deriving from food shortages, there are several dysfunctions caused by an incorrect diet.

For example, by administering deteriorated fodder, or ration with insufficient energy content and high lipid content, ketosis or acetonemia can occur, which can cause serious damage to the animal's liver, with strong repercussions on the animal's productive capacity.

Other examples of incorrect nutrition are the excessive administration of foods rich in carbohydrates and the excess of concentrated feeds that can lead to the blocking of ruminal activity with consequent arrest of milk production.

In this situation, the technical task underlying the present invention is to devise a bovine supplement capable of substantially obviating at least part of the aforementioned drawbacks. Within the scope of said technical task, it is an important object of the invention to obtain a bovine supplement which, if added to a normal diet, allows to counterbalance nutritional imbalances guaranteeing the good health of the animal and therefore a production of milk characterized by high quantities and high quality. The technical task and the specified aims are achieved by a bovine supplement as claimed in the attached claim 1 . Examples of preferred embodiment are described in the dependent claims.

In the present document, the measurements, values, shapes and geometric references (such as perpendicularity and parallelism), when associated with words like “about” or other similar terms such as “approximately” or “substantially”, are to be considered as except for measurement errors or inaccuracies due to production and/or manufacturing errors, and, above all, except for a slight divergence from the value, measurements, shape, or geometric reference with which it is associated. For instance, these terms, if associated with a value, preferably indicate a divergence of not more than 10% of the value.

Moreover, when used, terms such as “first”, “second”, “higher”, “lower”, “main” and “secondary” do not necessarily identify an order, a priority of relationship or a relative position, but can simply be used to clearly distinguish between their different components.

The measurements and data reported in this text are to be considered, unless otherwise indicated, as carried out in the ICAO International Standard Atmosphere (ISO 2533).

The bovine supplement is configured to be integrated into a bovine diet in order to express an increase in prolactin and increased milk production.

As described in detail below, the supplement is configured to make amino acids available to the bovine in the intestine, which are essential for development, tissue reconstruction, anabolic metabolism and milk production. In detail, the bovine supplement is configured to ensure adequate availability of N and carbohydrates in the rumen to stabilize and increase the growth of rumen microorganisms and the production of microbial protein (MCP) and create favourable conditions for the use of the small intestine’s own amino acids intrinsic needs of the animal. More in detail, the bovine supplement is configured to promote digestion and absorption of nutrients and substances that increase milk production and quality and to intervene in the reduction of both nitrogen, phosphorus and calcium excretions in the faeces and gas emissions harmful both of the concentration of CO2, indole and other harmful elements.

The bovine supplement is configured to be mixed with other foods.

The bovine supplement can comprise extracts of Galega officinalis suitably deriving from the stem of Galega officinalis.

The extracts of Galega officinalis may include alkaloids (such as galegina, hydroxygalegina, galutolein).

Said extracts can also include at least one and in detail the totality of flavonic subderivatives, saponins, tannins, chromium salts (1 -5 ppm), vitamin C.

The content of Galega officinalis extracts can be substantially lower than 10 g/Kg in detail at 5 g/Kg and to be precise at 2.5g/Kg. It can be substantially comprised between 1 g/kg and 1 .5 g/kg.

In this document, the content of the various active ingredients is expressed as a g/kg ratio, i.e., the ratio between the weight of the ingredient (expressed in g) and the weight of the food (expressed in kg) administered to the animal.

The bovine supplement can comprise Trifolium pratense extracts suitably deriving from Trifolium pratense flower/inflorescences.

Trifolium pratense extracts may include isoflavones such as genistein and daidzein. Said extracts can also comprise at least one and in detail the totality of coumarin compounds, phenolic acids (salicidic acid), lucosides, cyanogenic acids, volatile acids, sitosterol, tocopherols, minerals such as calcium, copper, magnesium and phosphorus.

The content of Trifolium pratense extracts can be substantially higher than that of Galega officinalis extracts.

The content of Trifolium pratense extracts can be substantially at least equal to 10g/kg in detail substantially comprised between 10 g/kg and 50 g/kg. It can be substantially comprised between 20 g/Kg and 40g/Kg.

The bovine supplement may comprise Moringa oleifera extracts suitably derived from Moringa oleifera leaves, seeds, root and flowers.

Moringa oleifera extracts may include at least one and in detail the entirety of zeatin, quercetin, beta-sitosterol, caffeilchemical acid and k.empferol.

The content of Moringa oleifera extracts can be substantially lower than that of Galega officinalis extracts.

The content of Moringa oleifera extracts can be substantially lower than 5g/Kg and in detail at 1 ,5g/Kg. It can be substantially comprised between 0.5g/Kg and 0.9g/Kg. The bovine supplement can comprise extracts of Fucus vesiculosus suitably deriving from thallus of Fucus vesiculosus.

Fucus vesiculosus extracts may include left-handed vitamin C, alginic acid and marine pathogenic fighting bacteria responsible for the mastitis etiology of dairy cows.

Said extracts may also include at least one and in detail the totality of enzymes catalysing the metabolic processes and mineral salts such as sodium, potassium, phosphorus, calcium, magnesium, sulfur, chlorine, manganese, iodine, silicon, iron, copper, zinc, strontium, cobalt, nickel, molybdenum, lead, tin, bromine, silver, chromium, lithium.

The content of Fucus vesiculosus extracts can be substantially lower than that of Galega officinalis extracts.

The content of Fucus vesiculosus extracts can be substantially lower than 5g/Kg and in detail at 2g/Kg. It can be substantially comprised between 0,6g/Kg and 1 g/Kg. The bovine supplement may comprise Medicago sativa extracts suitably derived from Medicago sativa leaves.

Medicago sativa extracts may include isoflavones, policosanols, saponins and folic acid.

The content of Medicago sativa extracts can be substantially lower than that of Galega officinalis extracts.

The content of Medicago sativa extracts can be substantially lower than 3g/Kg and in detail at 1 g/Kg. It can be substantially comprised between 0.3 g/kg and 0.6 g/kg. The bovine supplement can include extracts of Urtica dioica L. (hereinafter simply Urtica dioica) suitably deriving from the stem of Urtica dioica.

The extracts of Urtica dioica can include at least one and in detail the totality of iron, calcium, silicon, magnesium, phosphorus, vitamins A, C and K, formic and gallic acids, chlorophyll, tannin, carotene and histamine.

The content of Urtica dioica extracts can be substantially lower than that of Galega officinalis extracts.

The content of Urtica dioica extracts can be substantially lower than 2g/Kg and in detail at 0.5g/Kg. It can be substantially comprised between 0.15 g/kg and 0.3g/kg. The bovine supplement may comprise wheat germ extracts.

Wheat germ extracts can include lecithin, octacosanol, vitamins of groups A, B and

D.

Said extracts can also include at least one and in detail all of calcium, potassium, silicon, phosphorus, sulfur, zinc, copper, iron magnesium, manganese, selenium and molybdenum.

The content of wheat germ extracts can be substantially higher than that of Galega officinalis extracts.

The content of wheat germ extracts can substantially be at least 50 g/kg substantially comprised between 100 g/kg and 500g/kg. It can be substantially comprised between 150 g/Kg and 300g/Kg.

The bovine supplement can comprise Glycine max extracts suitably derived from Glycine max seeds.

The extracts of Glycine max can comprise coenzyme Q10 and they can also comprise at least one and in detail the entirety of isoflavones and phytoestrogens.

The content of Glycine max extracts can be substantially lower than that of Galega officinalis extracts.

The content of Glycine max extracts can be substantially lower than 5g/Kg and in detail at 2g/Kg. It can be substantially comprised between 0,6g/Kg and 0,8g I Kg.

The bovine supplement can comprise extracts of Trigonella foenum graecum appropriately deriving from seeds of Trigonella foenum graecum.

The extracts of Trigonella foenum can include at least one and in detail the totality of carbohydrates, vitamins A, B, C, iron, volatile oils, betaine, calcium, choline alkaloid, diosgenin (estrogenic-like action), lecithin, mucilage, phosphates, proteins, trigonellin alkaloid, trimethylamine. The content of Trigonella foenum graecum extracts can be substantially equal to that of Galega officinalis extracts.

The content of Trigonella foenum graecum extracts can be substantially lower than 10 g/kg in detail at 5 g/kg and to be precise 3g/kg. It can be substantially comprised between 1 g/kg and 2 g/kg.

The bovine supplement may comprise Silybum marianum extracts suitably derived from Silybum marianum seeds.

Silybum marianum extracts may include bioflavonoids (phytoestrogens called flavolignans).

The content of Silybum marianum extracts can be substantially lower than that of Galega officinalis extracts.

The content of Silybum marianum extracts can be substantially lower than 5g/Kg and in detail at 2g/Kg. It can be substantially comprised between 0,6g/Kg and 1 ,2g/Kg.

The bovine supplement can comprise extracts of Cnicus benedictus Gaertner suitably deriving from stem of Cnicus benedictus Gaertner.

The extracts of Cnicus benedictus Gaertner can include at least one and in detail the totality of cnicin, the benedectin (bitter glycosides) resin, tannin, gum, mucilage, sugars, phytosterin, magnesium, potassium and vitamin B1.

The content of Cnicus benedictus Gaertner extracts can be substantially at least equal to that of Galega officinalis extracts.

The content of Cnicus benedictus Gaertner extracts can be substantially lower than 10g/Kg and in detail at 7.5g/Kg. It can be substantially comprised between 1 g/Kg and 4g/Kg.

The bovine supplement may comprise Carum carvi extracts suitably derived from Carum carvi fruit.

Carum carvi extracts may comprise essential oil comprising carvone and limonene, fatty acids, proteins, carbohydrates, tannin and cellulose.

The content of Carum carvi extracts can be substantially lower than that of Galega officinalis extracts.

The content of Carum carvi extracts can be substantially lower than 1 g/Kg and in detail at 0.3 g/Kg. It can be substantially comprised between 0.06 g/Kg and 0.15g/Kg.

The bovine supplement may comprise lllicium anisatum extracts suitably derived from lllicium anisatum seed. lllicium anisatum extracts may comprise trans-anethole.

Said extracts can furthermore comprise at least one and in detail the totality of phellandrene, limonene, cineole, estragolo, methylcarvicolo and anisic aldehyde.

The content of lllicium anisatum extracts can be substantially lower than that of Galega officinalis extracts.

The content of lllicium anisatum extracts can be substantially lower than 2g/Kg and in detail at 0.5g/Kg. It can be substantially comprised between 0.2 g/Kg and 0.3g/Kg. The bovine supplement can comprise extracts of Pimpinella anisum suitably deriving from fruits of Pimpinella anisum.

The extracts of Pimpinella anisu can include at least one and in detail the totality of anethole, coumarins, furocoumarins, flavonoids, triterpenes and polyphenols.

The content of Pimpinella anisum extracts can be substantially lower than that of Galega officinalis extracts.

The content of Pimpinella anisum extracts can be substantially lower than 2g/Kg and in detail at 0.5g/Kg. It can be substantially comprised between 0.2 g/Kg and 0.3g/Kg.

The bovine supplement can include extracts of Foeniculum officinale appropriately derived from roots and fruits of Foeniculum officinale.

The extracts of Foeniculum officinale can include at least one and in detail the totality of anethole, fencone, anisic ketone, dipinene, camphene, fellandrene, dipentene and methylcavicular acid.

The content of Foeniculum officinale extracts can be substantially lower than that of Galega officinalis extracts.

The content of Foeniculum officinale extracts can be substantially lower than 2g/Kg and in detail at 0.5g/Kg. It can be substantially comprised between 0.15 g/kg and 0.23 g/kg.

In a non-limiting example of formulation, the bovine supplement can have a content of said extracts of Galega officinalis which is substantially comprised between 1 g/kg and 1 .5 g/kg; a content of said Trifolium pratense extracts is substantially comprised between 20 g/kg and 40 g/kg; a content of said Moringa oleifera extracts is substantially comprised between 0.5 g/kg and 0.9 g/kg; a content of said Fucus vesiculosus extracts is substantially comprised between 0.6 g/kg and 1 g/kg; a content of said Medicago sativa extracts is substantially comprised between 0.3 g/kg and 0.6 g/kg; a content of said extracts of Urtica dioica is substantially comprised between 0.15 g/kg and 0.3 g/kg; a content of said wheat germ extracts is substantially comprised between 150 g/kg and 30 0 g/kg; a content of said max Wisteria extracts is substantially comprised between 0.6 g/kg and 0.8 g/kg; a content of said extracts of Trigonella foenum graecum is substantially comprised between 1 g/kg and 2 g/kg; a content of said extracts of Silybum marianum is substantially comprised between 0.6 g/kg and 1.2 g/kg; a content of said extracts of Cnicus enedictus Gaertner is substantially comprised between 1 g/kg and 4 g/kg; a content of said Carum carvi extracts is substantially comprised between 0.06 g/kg and 0.15 g/kg; a content of said lllicium anisatum extracts is substantially comprised between 0.2 g/kg and 0.3 g/kg; a content of said Pimpinella anisum extracts is substantially comprised between 0.2 g/kg and 0.3 g/kg; and a content of said Foeniculum officinale extracts is substantially comprised between 0.15 g/kg and 0.23 g/kg.

The extracts described above are obtainable, preferably, by reflux extraction of the enedic type and in particular, with ultrasounds or with supercritical gases, and the addition of sulfur dioxide as a solvent. Preferably, these extracts are obtained by the enedic method under reflux with methanol. This method involves fermentation and hydrolysis of the plant part (for example fruit, flower or leaf) from which to obtain the extracts with the addition of yeast suitably Saccharomycetaceae (such as Saccharomyces cerevisiae) and preferably operating at Ph 7 for about 4 days; evaporation and centrifuge to eliminate the solvent from the solution obtained above; enedic extraction; elimination by heating to boiling point of methanol and then its extraction by evaporation.

It is highlighted how other methods configured to have the described above extracts containing said active ingredients can be adopted.

The operation of the bovine supplement described above is as follows.

The bovine supplement, suitably added to the normal diet of the animal, expresses an important action favouring the reconstruction of tissues, anabolic metabolism and milk production.

In fact, the presence of the extracts of Galega officinalis gives the bovine supplement the protective capacity of the mammary gland and the tonicity of the breast and also an important galactogenic action through its dopamine antagonist action and causing an increase in prolactin.

The protective action of the gland of the extracts of Galega officinalis can be assisted by the extracts of Fucus vesiculosus which expresses a defence action against pathogens responsible for the mastitis etiology of dairy cows and the elimination of milk suspensions. Added to this are the extracts of Medicago sativa which increase the animal’s defences thanks to their energetic action and increase the resistance of the organism.

The aforementioned galactogenic action is innovatively synergistic with the principles contained in Moringa oleifera which, in addition to significantly increasing antioxidants, improves lactation and prolactin levels.

Furthermore, the galactogenic action is also expressed thanks to the active ingredients of the extracts of Silybum marianum, Trigonella foenum graecum, Urtica dioica, Cnicus enedictus Gaertner, of Carum carvi, lllicium anisatum, Pimpinella anisum and Foeniculum officinale.

The aforementioned action of the bovine supplement favouring the production of milk is favoured by the estrogen-like effects, typical of some selected extracts, assisting the above-described milk production. In detail, the extracts of Trifolium pratense, of Silybum marianume appropriately of Glicine max carry out an estrogenic-like action to restore functional metabolic balance and therefore improve milk production. This action is assisted by the dioecious Urtica which, thanks to its creatine content, helps digestion and assimilation of food with a consequent positive impact on functional metabolic balance and milk production.

The bovine supplement according to the invention achieves important advantages.

In fact, thanks to the particular selection of extracts, the bovine supplement expresses important actions capable of both promoting the metabolism and the animal's defences, avoiding a reduction in milk production and quality.

In detail, the bovine supplement promotes digestion and absorption of nutrients and substances that increase the production and quality of milk and intervenes in the reduction of both nitrogen, phosphorus and calcium excretions in the faeces, both emissions of harmful gases and concentration, of CO2, indole and other harmful elements.

The invention is susceptible of variants falling within the scope of the inventive concept defined by the claims. In this context, all the details can be replaced by equivalent elements and the materials, shapes and dimensions can be any.

Claims

1. Bovine supplement characterized by including extracts of Galega officinalis, Trifolium pratense, Silybum marianum, Moringa oleifera, Cnicus benedictus Gaertner. Carum carvi, lllicium anisatum, Foeniculum officinale, Pimpinella anisum, Urtica dioica and Trigonella foenum graecum.

2. Bovine supplement according to claim 1 , in which the content of said extracts of Galega officinalis is substantially lower than 2.5 g/kg; the content of said extracts of Trifolium pratense is substantially at least equal to 10 g/kg in detail substantially is between 10 g/kg and 50 g/kg; the content of said Moringa oleifera extracts is substantially lower than 1.5 g/kg; the content of said extracts of Urtica dioica is substantially lower than 0.5 g/kg; content of said extracts of Trigonella foenum graecum is substantially lower than 5 g/kg; content of said extracts of Silybum marianum is substantially lower than 2 g/kg; content of said extracts of Cnicus benedictus Gaertner is substantially lower than 7.5g/kg ; content of said Carum carvi extracts is substantially lower than 0.3 g/kg; content of said lllicium anisatum extracts is substantially lower than 0.5 g/kg; content of said extracts of Pimpinella anisum is substantially lower than 0.5 g/kg; the content of said extracts of Foeniculum officinale is substantially lower than 0.5 g/kg.

3. Bovine supplement according to at least one previous claim, comprising Fucus vesiculosus extracts.

4. Bovine supplement according to the previous claim, in which the content of said Fucus vesiculosus extracts is substantially lower than 5 g/kg and in detail at 2 g/kg.

5. Bovine supplement according to at least one preceding claim, comprising Medicago sativa extracts.

6. Bovine supplement according to the preceding claim, in which the content of said Medicago sativa extracts is substantially lower than 3 g/kg and in detail at 1 g/kg.

7. Bovine supplement according to at least one preceding claim, comprising wheat germ extracts.

8. Bovine supplement according to the preceding claim, in which the content of said wheat germ extracts is substantially at least equal to 50 g/kg is substantially between 100 g/kg and 500 g/kg.

9. Bovine supplement according to at least one preceding claim, comprising Glicine max extracts; and in which the content of said max Wisteria extracts is substantially lower than 2 g/kg.

10. Bovine supplement according to claims 1 -9, wherein said content of said extracts of Galega officinalis is substantially between 1 g/kg and 1.5 g/kg; said content of said Trifolium pratense extracts is substantially between 20 g/kg and 40 g/kg; said content of said Moringa oleifera extracts is substantially between 0.5 g/kg and 0.9 g/kg; said content of said Fucus vesiculosus extracts is substantially between 0.6 g/kg and 1 g/kg; said content of said Medicago sativa extracts is substantially between 0.3 g/kg and 0.6 g/kg; said content of said extracts of Urtica dioica is substantially between 0.15 g/kg and 0.3 g/kg; said content of said wheat germ extracts is substantially comprised between 150 g/kg and 300 g/kg; said content of said max Wisteria extracts is substantially between 0.6 g/kg and 0.8 g/kg; said content of said extracts of Trigonella foenum graecum is substantially between 1 g/kg and 2 g/kg; said content of said Silybum marianum extracts is substantially between 0.6 g/kg and 1.2 g/kg; said content of said Cnicus benedictus Gaertner extracts is substantially between 1 g/kg and 4 g/kg; said content of said Carum carvi extracts is substantially between 0.06 g/kg and 0.15 g/kg; said content of said lllicium anisatum extracts is substantially between 0.2 g/kg and 0.3 g/kg; said content of said extracts of Pimpinella anisum is substantially between 0.2 g/kg and 0.3 g I kg; and said content of said extracts of Foeniculum officinale is substantially between 0.15 g/kg and 0.23 g/kg.

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