WO2022105848A1

WO2022105848A1 - Laser thermoplasty treatment device for bronchial asthma

Info

Publication number: WO2022105848A1
Application number: PCT/CN2021/131616
Authority: WO
Inventors: 毕勇; 孙礼朋
Original assignee: 毕勇; 孙礼朋
Priority date: 2020-11-20
Filing date: 2021-11-19
Publication date: 2022-05-27
Also published as: CN112494135A

Abstract

A laser thermoplasty treatment device for bronchial asthma, comprising: a laser source (10), a catheter (20) and a balloon (30) arranged at one end of the catheter (20). An optical fiber is provided in the catheter (20). A first end of the optical fiber is used as a laser input end to connect to the laser source (10). A second end of the optical fiber is positioned in the balloon (30) and is used as a laser output end for irradiating the laser light emitted by the laser source (10) into biological tissue. In the process of thermal ablation of biological tissue by means of thermal effect, the present laser thermoplasty treatment device has advantages such as high safety, high accuracy, high efficiency, and low cost.

Description

A laser thermoforming treatment device for bronchial asthma

technical field

The present application relates to the technical field of medical devices. More specifically, it relates to a laser-based laser thermoforming device for bronchial asthma.

Background technique

At present, the treatment of some diseases requires the use of radiofrequency thermoplasty. Take the use of radiofrequency thermoforming devices for bronchial asthma as an example:

Bronchial asthma (Asthma) is a common chronic airway inflammatory disease characterized by reversible airflow limitation. According to statistics, 300 million people worldwide are sick, and more than 10 million people are sick in China. The etiology and pathogenesis of bronchial asthma are very complex and have not yet been fully elucidated. At present, asthma patients often use hormones, β2-receptor agonists, leukotriene modifiers, etc. to control their disease, but 5%-10% of patients cannot be relieved by conventional treatment. Although such patients use a large amount of inhaled hormones, even oral administration Hormones are still not well controlled, and there are still acute exacerbations, namely severe asthma (severe asthma).

The role of airway smooth muscle (ASM) in the pathogenesis of asthma has received increasing attention. Airway narrowing due to ASM hyperplasia is one of the main pathogenesis of asthma. If the lungs are frequently irritated, both the number and volume of ASMs can change, resulting in a thickening of the ASM layer and narrowing of the airways.

The principle of bronchial thermoplasty (BT) is mainly to precisely control the release of energy at the designated site, and to achieve the purpose of removing the hyperplasia of ASM and restoring the patency of the airway after reaching the required temperature and action time. Existing technical solutions (such as the AlairTM system developed by Asthmatx in the United States) mainly use the method of radiofrequency ablation (RFA), which is called radiofrequency thermoplasty. Electromagnetic waves, through radio frequency, make the charged ions in the tissue oscillate to generate heat, transfer heat to the airway smooth muscle, and reduce the contractility and hyperresponsiveness of the airway smooth muscle (reduce the number of airway smooth muscle) by means of temperature regulation treatment. The cells of hypertrophic smooth muscle coagulate and necrosis, and finally achieve the purpose of ablating the airway smooth muscle layer, reducing airway reactivity, and partially reversing the remodeling of airway structure.

The existing RF thermoplasty solutions mainly have the following problems:

First, radiofrequency thermoplasty is a direct contact treatment method. During the surgical operation, the radiofrequency electrode is in close contact with the inner wall of the human trachea after being electrified and heated, which can easily damage the tracheal intima, resulting in infection or scarring and easy generation. Granulation, which poses additional risks and side effects to the patient.

Second, the use of radiofrequency thermoplasty to treat severe asthma has a long treatment cycle, which virtually increases the physical pain and economic burden of the patient. The whole lung treatment process is divided into three stages: the right lower lobe, the left lower lobe, and the left and right upper lobes, and each stage is treated 3 weeks apart. In each treatment, electrodes are used to introduce AC electromagnetic waves into the airway smooth muscle to stimulate the charged ions in the tissue to oscillate and generate heat, so as to achieve the purpose of thermal ablation of the smooth muscle tissue. The treatment time of each stage lasts 30 minutes or longer, and the treatment cycle is too long and the efficiency is low.

Third, radiofrequency thermoplasty is constrained by the structure of the inner wall of the airway, and the treatment area is limited. Radiofrequency thermoplasty is an energy coupling method that uses four electrode contacts to contact the inner wall of the trachea. When the airway smooth muscle is severely contracted or has an irregular shape, the four electrodes may not be in complete contact with the inner wall of the airway, resulting in inability to Effective use of thermoplasty for surgical treatment.

Fourth, the electrodes in radiofrequency thermoplasty, as disposable medical consumables, are expensive.

SUMMARY OF THE INVENTION

The purpose of the present application is to provide a laser thermoforming treatment device for bronchial asthma to solve at least one of the problems existing in the prior art.

In order to achieve the above object, the application adopts the following technical solutions:

A first aspect of the present application provides a laser thermoforming treatment device for bronchial asthma, comprising: a laser light source, a catheter, and a balloon disposed at one end of the catheter, and an optical fiber is disposed in the catheter; a first end of the optical fiber As a laser input end, it is connected to the laser light source; the second end of the optical fiber is located in the balloon and serves as a laser output end, used for irradiating the biological tissue with the laser light emitted by the laser light source.

In a possible implementation manner, the device further includes an optical shaping module disposed between the laser light source and the optical fiber, for shaping the laser light emitted by the laser light source so that the irradiation spot of the laser light is Ring-shaped or multi-lobed.

In a possible implementation manner, the optical shaping module includes a first optical device arranged in sequence along the optical path for compressing the irradiation spot size of the laser light, and for shaping the irradiation spot of the laser into an annular or multi-lobed shape. The second optical device and the third optical device for coupling laser light, wherein the first optical device is a stepped mirror or a rhombus prism group, the second optical device is a conical mirror, and the third optical device is a conical lens or a pyramid lens.

In a possible implementation, the device further includes a temperature sensor for sensing the temperature in the vicinity of the biological tissue.

In a possible implementation, the device further includes an image capturer for capturing an image of the front of the balloon.

In a possible implementation manner, the wavelength range of the laser light emitted by the laser light source is 380 nm˜2100 nm.

In a possible implementation manner, the temperature sensor is a thermocouple temperature sensor or a platinum resistance temperature sensor.

In a possible implementation manner, the apparatus further includes a control module, configured to adjust the output power of the laser light source according to the temperature sensed by the temperature sensor.

In a possible implementation manner, the apparatus further includes a display module, configured to display the temperature sensed by the temperature sensor, the image collected by the image collector, the output power of the laser light source, and the duration of the laser irradiation. at least one of.

In a possible implementation manner, the device further includes a manipulation handle device for manipulating the movement of the balloon.

The beneficial effects of the present invention are as follows:

Compared with the existing radio frequency thermoplasty, the "laser thermoplasty" adopted in the technical solution of the present invention has many advantages such as high safety, high accuracy, high efficiency, low cost, and the like.

Description of drawings

The specific embodiments of the present application will be described in further detail below with reference to the accompanying drawings.

FIG. 1 shows a schematic diagram of a laser thermoforming device for bronchial asthma provided by an embodiment of the present application.

Figure 2 shows a schematic diagram of an optical shaping module.

In FIG. 3 , 3-a shows a schematic diagram of a ring-shaped light spot, and 3-b shows a schematic diagram of a multi-lobed light spot.

Figure 4 shows a schematic diagram showing the entry of a balloon from the oral cavity into the airways of the lungs.

Figure 5. Schematic diagram of laser irradiation of airway smooth muscle in the airway of the lung.

Detailed ways

In order to illustrate the present application more clearly, the present application will be further described below with reference to the embodiments and the accompanying drawings. Similar parts in the figures are denoted by the same reference numerals. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present application.

In order to solve the problems of low safety, long treatment period, low efficiency, low effectiveness and precision, and high cost of existing radio frequency thermoforming devices, an embodiment of the present application provides a laser-based thermoforming device. forming device.

As shown in FIG. 1 , the laser thermoforming treatment device for bronchial asthma provided in this embodiment includes: a laser light source 10, a catheter 20, and a balloon 30 arranged at one end of the catheter 20. An optical fiber is arranged in the catheter 20; The second end of the optical fiber is located in the balloon 30 and serves as a laser output end, which is used to make the laser emitted from the laser light source 10 irradiate the biological tissue, so as to realize thermal ablation of the biological tissue through thermal effect. .

In some embodiments, the laser thermoforming device for bronchial asthma provided in this embodiment further includes a control module 40 for controlling the laser light source 10 to emit laser light.

In one specific example, the balloon 30 may be made of silicone, polyurethane, nitinol material or other superelastic material, and has a conical or cylindrical shape. The light-emitting device in the laser light source 10 can be a semiconductor laser, an all-solid-state laser, a fiber laser, a gas laser, etc., preferably a semiconductor laser; the average output power of the laser light source 10 is adjustable, and the adjustment range of the average power can be set to 0-20W ; The modulation mode of the control module 40 for the laser light source 10 can be current value adjustment (the current adjustment accuracy is, for example, 0.1A), or PWM modulation; the laser light emitted by the laser light source 10 can be a continuous laser or a discontinuous laser; The laser light emitted by the light source 10 may be visible light or infrared light (including near-infrared light and mid-infrared light), and the wavelength range of the laser light emitted by the laser light source 10 is 380 nm˜2100 nm. The optical fiber can be a silica optical fiber, a glass optical fiber, etc.; the core diameter of the optical fiber ranges from 50 microns to 500 microns;

Continuing from the foregoing example, the laser thermoforming device for bronchial asthma provided in this embodiment is used to thermally ablate the proliferated airway smooth muscle to treat bronchial asthma. That is, the above-mentioned biological tissue is airway smooth muscle. When the balloon 30 enters the airway tube through the patient's nasal cavity or oral cavity and reaches the position of the airway smooth muscle, the laser light emitted by the laser light source 10 is transmitted through the optical fiber in the catheter 20 to illuminate the airway smooth muscle. , to achieve thermal ablation of airway smooth muscle through thermal effect, thereby treating bronchial asthma.

In some embodiments, the laser thermoforming treatment device for bronchial asthma provided in this embodiment further includes a manipulation device 50 for manipulating the movement of the balloon 30 .

Continuing the previous example, the balloon 30 is disposed at the top of the catheter 20, and the catheter 20 is a hollow thin tube (typically a bronchoscope) with a degree of bending. The optical fibers also follow the balloon 30 into the airway. The laser output end of the optical fiber is not only located in the balloon 30 , but also can be arranged such that the optical fiber passes through the balloon 30 so that the laser output end of the optical fiber is located in front of the balloon 30 . The control device 50 is, for example, a handle or a joystick, or a touch module implemented by a touch screen, which can control the movement of the balloon 30 and the catheter 20, including the movement distance (forward distance, backward distance), movement direction (turning distance). )Wait. In addition to controlling the movement of the balloon 30 and the catheter 20, the manipulation device 50 can also control the opening or closing of the balloon 30. For example, in order to further improve safety, when the laser output end of the optical fiber is located in the balloon 30, The manipulation device 50 can control the closing of the balloon 30 during the process of controlling the movement of the balloon 30 and the catheter 20, and when the balloon 30 reaches a predetermined position, that is, when the laser output end of the optical fiber is facing the airway smooth muscle to be ablated, the balloon 30 is controlled. Open to expose the laser output end of the fiber.

In some embodiments, the laser thermoforming treatment device for bronchial asthma provided in this embodiment further includes a temperature sensor for sensing the temperature near the biological tissue. Therefore, the thermal ablation effect can be determined according to the temperature near the biological tissue sensed by the temperature sensor, which provides a basis for controlling the temperature of thermal ablation by manually or automatically controlling the output power of the laser light source 10 . Further, the temperature sensor can be a thermocouple temperature sensor, a platinum resistance temperature sensor, and a thermistor temperature sensor. Among them, a thermocouple temperature sensor or a platinum resistance temperature sensor is preferably used, which has the advantages of high precision and high stability, and the precision is 0.1 ℃ or so. Continuing from the previous example, the temperature sensor is used to sense the temperature near the airway smooth muscle to be ablated. For the airway smooth muscle to be ablated, the set target temperature for thermal ablation through thermal effect is between 55°C and 65°C, and a thermocouple is used. A temperature sensor or platinum resistance temperature sensor can meet requirements such as accuracy. It can be understood that the temperature sensor may be positioned close to the laser output end of the optical fiber. In addition, for the case where the laser output end of the optical fiber is located in the balloon 30, the temperature sensor can also be arranged outside the front of the balloon 30, so that the temperature sensor is closer to the airway smooth muscle to be ablated.

In some embodiments, the control module 40 is configured to adjust the output power of the laser light source 10 according to the temperature sensed by the temperature sensor. Therefore, the control module 40 can sense the temperature near the biological tissue through the temperature sensor, and perform closed-loop control of the output power of the laser light source 10, so as to perform thermal ablation of the biological tissue more accurately and controllably, and improve the safety and effectiveness of the treatment. sex, to ensure the therapeutic effect.

In some embodiments, the laser thermoforming device for bronchial asthma provided in this embodiment further includes an image acquisition device for acquiring an image of the front of the balloon 30 . Further, the image collector may be an endoscopic camera or a miniature camera. As a result, an endoscopic view can be provided, enabling more precise movements and viewing thermal ablation effects on biological tissue. Continuing from the previous example, the image acquisition device is a CMOS device, which can be disposed outside the front of the balloon 30 . On the one hand, the image collected by the image collector can be used to provide a real-time picture of the moving position in the process of controlling the movement of the balloon 30 and the catheter 20 through the manipulation device 50, so as to assist the manipulation and achieve more accurate movement of the balloon 30 to the position of the catheter 20. The position of the airway smooth muscle to be ablated, so that the laser output end of the optical fiber can be more accurately aligned with the airway smooth muscle to be ablated; on the other hand, users such as doctors can also view the airway according to the images collected by the image collector. The thermal ablation effect of smooth muscle can be used to determine whether to increase/decrease the output power of the laser light source, prolong the laser irradiation time, etc., so as to ensure the therapeutic effect.

With reference to the foregoing examples, the control module 40 may control the laser light source 10 through signals or instructions in response to an input control command or based on preset control parameters, so as to adjust the driving current of the laser light source 10 to control the laser light source 10 to emit laser light, The control module 40 can be equipped with operating devices such as emergency stop switch and foot switch controller; The change of the above-mentioned temperature value automatically adjusts the driving current value of the laser light source 10 or the duty cycle of the PWM control signal, thereby controlling the output power of the laser light source 10 to achieve stable control of the temperature of the inner wall of the bronchus irradiated by the laser (for example, set The predetermined target temperature is between 55°C and 65°C, and the output power of the laser light source 10 is controlled by comparing the temperature value sensed by the temperature sensor with the target temperature, so that the temperature of the thermal ablation position is controlled at 55°C-65°C between, that is, the temperature of the airway smooth muscle at the place where the laser is irradiated reaches the optimal therapeutic temperature value); the thermal ablation of the airway smooth muscle in the bronchus can also be realized according to the received endoscopic image of the trachea collected by the image collector. Real-time monitoring of status.

In a specific example, the temperature sensor and the image collector may be connected to the control module 40 through cables, respectively, and the two cables may be respectively disposed in the conduit 20 . For example, the catheter 20 is provided with an optical fiber, a connection cable for the temperature sensor, and a connection cable for the image acquisition device. It should be noted that, in this case, in combination with the foregoing examples, the laser output end of the optical fiber can be set at the opening of the balloon 30 After the balloon 30 is opened, the laser output end of the optical fiber is located in the center of the bronchial airway, which is convenient to achieve centering, wherein the laser output end of the optical fiber and the balloon 30 can adopt an integrated design.

In some embodiments, the laser thermoforming treatment device for bronchial asthma provided in this embodiment further includes a display module 60 for displaying the temperature sensed by the temperature sensor, the image collected by the image collector, the output power of the laser light source 10, the laser At least one of the irradiation durations may also display other information such as the drive current value of the laser light source 10 . In addition, information such as the temperature sensed by the above temperature sensor, the image collected by the image collector, the output power of the laser light source 10, and the duration of laser irradiation can also be stored in the memory.

In a specific example, the control module 40, the manipulation module 50 and the display module 60 can be integrated into a terminal device, wherein the manipulation module 50 and the display module 60 can be integrated into the touch screen of the terminal device, and the control module 40 can be used to control the When the laser light source 10 is turned on/off, or parameters such as the output power of the laser light source 10 are controlled, the touch screen can also be used for input. The terminal device can be various electronic devices, including but not limited to personal computers, tablet computers, medical instruments and so on.

In some embodiments, as shown in FIGS. 1 and 2 , the laser thermoforming treatment device for bronchial asthma provided in this embodiment further includes an optical shaping module 70 disposed between the laser light source 10 and the optical fiber 80 , and is used for aligning the laser light source. 10. The outgoing laser light is shaped so that the irradiation spot of the laser light is annular or multi-lobed. As a result, the uniformity of the laser light irradiated on the biological tissue can be improved, and the therapeutic effect can be ensured.

Further, as shown in FIG. 2 , the optical shaping module 70 includes a rhombus prism group 701 arranged in sequence along the optical path for compressing the size of the irradiation spot of the laser light, and for shaping the irradiation spot of the laser into an annular or multi-lobed shape. The conical mirror 702 and the lens group 703 for coupling laser light, wherein the annular light spot is shown as 3-a in FIG. 3 , and the multi-lobed light spot is shown as 3-b in FIG. 3 . In a specific example, the rhombus prism group 701 is, for example, a pair of glued rhombus prisms as shown in FIG. 2 . After the laser light emitted from the laser light source 10 passes through the rhombus prism group 701 , the spot size is compressed, and the laser light with the compressed spot size passes through the rhombus prism group 701 . The conical mirror 702 becomes the laser light of the annular spot, and the laser light of the annular spot is coupled into the optical fiber 80 after passing through the lens group 703 . The materials of the optical devices of the rhombus prism group 701 , the conical mirror 702 and the lens group 703 may be optical glass, optical resin material, or the like. Lens group 703 may include conical lenses or pyramid lenses.

In addition, the rhombic prism group 701 can also be replaced by a stepped mirror, that is, the stepped mirror is used to compress the irradiation spot size of the laser light.

Continuing the previous example, the workflow of the laser thermoforming treatment device for bronchial asthma provided in this embodiment is, for example: through the catheter 20, the optical fiber is put into the bronchi of the patient, the operation device 40 controls the balloon 30, and the laser light source 10 is emitted The laser light shaped by the optical shaping module 70 is transmitted to the affected part of the bronchus through the optical fiber to achieve centering, and the formed annular light spot or multi-lobed light spot is used to irradiate the inner wall of the bronchus and generate a thermal effect, thereby coagulating the hyperplasia and hypertrophy smooth muscle cells. , necrosis, to achieve the purpose of ablating the airway smooth muscle layer, reducing airway reactivity, so as to achieve the effect of treating bronchial asthma. Among them, the laser shaped by the optical shaping module 70 forms a ring-shaped light spot or a multi-lobed light spot with uniform energy distribution and no gap, which can completely irradiate and cover the inner wall of the bronchus, and will not be unable to be treated due to severe contraction or deformation of the airway smooth muscle. The laser has the advantages of high energy, good directionality, high efficiency, and significant thermal effect when interacting with biological tissues, and can rapidly heat up in a short time. Laser thermoforming avoids contact with biological tissue, does not cause damage and side effects caused by contact, and is safer.

In another description, the operation method of the laser thermoforming device for bronchial asthma provided by this embodiment is, for example: inserting the catheter 20 → turning on the low-power mode of the laser light source 10 and guiding the balloon 30 and the laser output end of the optical fiber On the affected area → turn on the treatment mode of the laser light source 10 → output the annular light spot to irradiate the affected area (airway smooth muscle), and operate continuously to treat the entire bronchus. Among them, the local treatment temperature is between 55°C and 65°C, and each treatment part (affected part) is maintained for about 10 seconds; the patient moves from the distal affected part to the proximal affected part, and the above operations are repeated until the entire treatment process or operation is over. More specifically, the process includes: after the patient is anesthetized, lie down on the operating table, the balloon 30 and the catheter 20 enter the airway tube through the nasal cavity or the oral cavity, as shown in FIG. 4 , the balloon 30 is closed at this time; The module 50 controls the movement of the balloon 30, collects images in the airway in real time through the image collector and transmits them to the control module 40, and is displayed by the display module 60; after reaching the designated patient, the balloon 30 is opened through the operation module 50, and the display is displayed. The module 60 displays the setting interface; the ablation temperature is set at 65 degrees Celsius and the duration is 10s, the control module 40 controls the laser light source 10 to emit laser light, which is shaped by the optical shaping module 70 and output from the laser output end of the optical fiber, as shown in FIG. The light spot on the airway wall tissue is an annular light spot. The control module 40 adjusts the driving current value of the laser light source 10 according to the change of the temperature value sensed by the temperature sensor, so as to achieve stable temperature control in the human body, and the display module 60 displays the image of the irradiated tissue collected by the image collector in real time, so as to achieve disease control. Thermal ablation of affected tissue. By operating the module 50, the balloon 30 is moved, so that the formed annular light spot reaches the next patient position, and the treatment is continued.

After the treatment, the driving current of the laser light source 10 is adjusted to 0A by the control module 40 to turn off the laser light source 10; the balloon 30 is closed by the operation module 50, and the catheter 20 is pulled out to complete the treatment.

The specific experimental data of the laser light source based on blue semiconductor laser is shown in Table 1:

Table 1

Based on the above experimental data, it can be seen that when 442nm blue light semiconductor laser is used to irradiate tracheal tissue, when the power density is 8.92W/cm ² , it takes 6s for the tracheal tissue to heat up from the initial temperature to about 50°C, and it takes 6s to heat up to about 60°C. 10s.

In the actual treatment process, the local treatment temperature is controlled between 55°C and 65°C, and the treatment time for each part lasts about 10s. It can be performed one by one from far to near from the airway patient with a diameter of more than 3 mm to avoid repeated or missed treatment. Compared with radiofrequency thermoplasty, this embodiment greatly shortens the treatment time, which can reduce the pain and burden of the patient.

To sum up, the laser thermoforming treatment device for bronchial asthma provided in this embodiment utilizes the advantages of high efficiency, miniaturization, low cost, non-contact, and significant thermal effect in interaction with biological tissues, using laser as an energy source. thermoplasty to treat bronchial asthma and other diseases. At the same time, using the integration of catheter, balloon and optical fiber, as well as high-precision temperature sensing and feedback control system, a convenient, precise and controllable, safe and effective "laser thermoplasty" for the treatment of bronchial asthma is realized and other disease devices.

Continuing from the previous example, when used for thermal ablation of hyperplastic airway smooth muscle, compared with the existing radiofrequency thermoforming device, the most prominent advantages of the laser thermoforming device for bronchial asthma provided in this embodiment are reflected in the following two: aspect:

The first aspect, non-contact treatment, has high safety:

The "laser thermoplasty" used in this embodiment uses a laser as an energy source to couple the laser light emitted by the laser light source into a conducting fiber. The fiber enters the trachea along with the catheter and the balloon, and the laser output from the laser output end of the fiber forms a ring. It can irradiate the inner wall of the bronchus, so that the contracted smooth muscle tissue absorbs light energy and is heated, so that the smooth muscle cells coagulate and necrosis, so as to achieve the purpose of treatment. In this process, the contact between the therapeutic instrument and the human tissue is avoided, the damage and side effects caused by the contact will not be caused, and the safety is high.

The second aspect, the treatment efficiency is high and the time is short:

Laser has the advantages of high energy and good directionality, and has a significant thermal effect when interacting with smooth muscle tissue. It can heat up rapidly in a short time, and the treatment efficiency is high.

For a more clear and intuitive description, the laser thermoforming device for bronchial asthma provided in this example (referred to as laser thermoforming in Table 2) and the existing radio frequency thermoforming device (referred to as radio frequency thermoforming in Table 2) are shown in Table 2. The effect of molding) is compared to show:

Table 2

In the description of this application, it should be noted that the orientation or positional relationship indicated by the terms "upper", "lower", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the application and simplifying the description, Rather than indicating or implying that the referred device or element must have a particular orientation, be constructed and operate in a particular orientation, it should not be construed as a limitation on the application. Unless otherwise expressly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense, for example, it may be a fixed connection, a detachable connection, or an integral connection; it may be a mechanical connection, It can also be an electrical connection; it can be a direct connection, an indirect connection through an intermediate medium, or an internal connection between two components. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific situations.

It should also be noted that, in the description of this application, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply these There is no such actual relationship or sequence between entities or operations. Moreover, the terms "comprising", "comprising" or any other variation thereof are intended to encompass a non-exclusive inclusion such that a process, method, article or device that includes a list of elements includes not only those elements, but also includes not explicitly listed or other elements inherent to such a process, method, article or apparatus. Without further limitation, an element qualified by the phrase "comprising a..." does not preclude the presence of additional identical elements in a process, method, article or apparatus that includes the element.

Obviously, the above-mentioned embodiments of the present application are only examples for clearly illustrating the present application, rather than limiting the implementation of the present application. Changes or changes in other different forms cannot be exhausted here, and all obvious changes or changes derived from the technical solutions of the present application are still within the scope of protection of the present application.

Claims

A laser thermoforming treatment device for bronchial asthma, characterized in that it comprises: a laser light source, a catheter and a balloon arranged at one end of the catheter, an optical fiber is arranged in the catheter; the first end of the optical fiber is used as a laser input The second end of the optical fiber is located in the balloon, and serves as a laser output end, used for irradiating the biological tissue with the laser light emitted by the laser light source.
The device according to claim 1, characterized in that, the device further comprises an optical shaping module arranged between the laser light source and the optical fiber, for shaping the laser light emitted by the laser light source to make the The irradiation spot of the laser is annular or multi-lobed.
The device according to claim 2, wherein the optical shaping module comprises a first optical device arranged in sequence along the optical path for compressing the irradiation spot size of the laser light, and for shaping the irradiation spot of the laser into a ring or A multilobe second optical device and a third optical device for coupling laser light, wherein the first optical device is a stepped mirror or a rhombus prism group, the second optical device is a conical mirror, and the third optical device is a cone shape lens or pyramid lens.
The apparatus of claim 1, further comprising a temperature sensor for sensing a temperature near the biological tissue.
The device of claim 1, further comprising an image capturer for capturing an image of the front of the balloon.
The device according to claim 1, wherein the wavelength range of the laser light emitted by the laser light source is 380 nm to 2100 nm.
The device according to claim 4, wherein the temperature sensor is a thermocouple temperature sensor or a platinum resistance temperature sensor.
The device according to claim 4, characterized in that, the device further comprises a control module for adjusting the output power of the laser light source according to the temperature sensed by the temperature sensor.
The device according to any one of claims 1-8, characterized in that, the device further comprises a display module for displaying the temperature sensed by the temperature sensor, the image collected by the image collector, the laser At least one of the output power of the light source and the duration of laser irradiation.
The device of claim 1, further comprising a manipulation handle device for manipulating the movement of the balloon.