WO2022105383A1 - 试剂盒 - Google Patents

试剂盒 Download PDF

Info

Publication number
WO2022105383A1
WO2022105383A1 PCT/CN2021/117656 CN2021117656W WO2022105383A1 WO 2022105383 A1 WO2022105383 A1 WO 2022105383A1 CN 2021117656 W CN2021117656 W CN 2021117656W WO 2022105383 A1 WO2022105383 A1 WO 2022105383A1
Authority
WO
WIPO (PCT)
Prior art keywords
nozzle
hole
flow channel
air inlet
sealing
Prior art date
Application number
PCT/CN2021/117656
Other languages
English (en)
French (fr)
Inventor
郝书顺
眭彦军
陈立柱
邢士元
姚召辉
Original Assignee
石家庄禾柏生物技术股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 石家庄禾柏生物技术股份有限公司 filed Critical 石家庄禾柏生物技术股份有限公司
Publication of WO2022105383A1 publication Critical patent/WO2022105383A1/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the present invention relates to a kit.
  • Kits are common laboratory supplies used in the preservation of reaction reagents.
  • the reagents used in laboratories and testing instruments are extracted from the reagent box using a pipette or a syringe.
  • the pipette tip needs to be replaced, or the syringe and needle need to be cleaned, which is cumbersome and time consuming.
  • the amount of extraction is easily affected by the operator's operation method, which is not conducive to converting it into an automated instrument for operation.
  • the purpose of the present invention is to provide a reagent kit with a compact structure and suitable for automatic liquid extraction.
  • the present invention adopts following technical scheme:
  • a test kit which comprises a box body, an air inlet and a liquid outlet arranged on the side of the box body, and a liquid storage tank arranged on the box body; The other end of the liquid storage tank is connected with a liquid outlet, the air inlet is connected with an air inlet port, and the liquid outlet is connected with a liquid outlet device.
  • the elongated flow channel includes a first flow channel and a fourth flow channel arranged on the lower bottom surface of the box body and a second flow channel and a third flow channel arranged on the top surface of the box body.
  • the first flow channel, The second flow channel, the third flow channel, and the fourth flow channel are connected in sequence; a gas-liquid isolation trap is arranged between the liquid storage tank and the elongated flow channel;
  • the gas-liquid isolation trap includes a first trap groove set between the third flow channel and the fourth flow channel and a second trap groove set between the fourth flow channel and the liquid storage tank.
  • a first air column is provided, a second air column is arranged in the second trap groove, the third flow channel communicates with the first trap groove through the first air column, and the fourth flow channel communicates with the second air column Second trap slot.
  • the air inlet interface includes an air inlet connecting pipe communicating with the air inlet and a blocking pipe arranged at the other end of the air inlet connecting pipe, and a gas nozzle plug is arranged in the blocking pipe in an interference fit, and the gas
  • the nozzle plug is provided with an air intake blind hole along the axis, and the open end of the air intake blind hole faces the air intake connecting pipe.
  • the air inlet blind hole includes a frustum-shaped air inlet hole and a cylindrical air inlet hole that communicate with each other.
  • the air intake holes are connected, and the large bottom end of the frustum-shaped air intake holes is an open end.
  • the liquid outlet device includes a nozzle connected to the liquid outlet and a nozzle arranged at the end of the nozzle;
  • the nozzle includes a nozzle main body, a nozzle hole arranged in the axial direction of the nozzle main body, and a magnet bar arranged in the nozzle hole.
  • the inner wall of the nozzle hole is evenly provided with a number of retaining bars along the nozzle hole axis.
  • One end of each of the baffles is provided with a shoulder extending toward the center of the spray hole, and the magnet bar moves along the axial direction of the spray hole in the space enclosed by the shoulder and the baffle.
  • the nozzle includes an annular sleeve, an end plate arranged at one end of the annular sleeve, a nozzle tube arranged in the center of the end plate, and a conical spout arranged at the end of the nozzle tube, and the end plate is also provided with a surrounding
  • a liquid channel communicating with the inside of the annular sleeve is arranged in the nozzle tube and the conical nozzle, and an annular groove is formed between the nozzle tube and the annular rib; the annular groove is formed.
  • the casing is screwed or clamped with the main body of the nozzle.
  • a sealing valve is arranged in the annular sleeve;
  • the sealing valve comprises a sealing valve body and a cylindrical valve hole arranged on the sealing valve body, the bottom end of the valve hole is provided with a frustum hole, the cone
  • the truncated hole and the valve hole are coaxially arranged, the small bottom end of the truncated cone hole is communicated with the bottom end of the valve hole; the valve hole is communicated with the spray hole, and the truncated cone hole is communicated with the liquid channel.
  • a sealing cover is provided outside the nozzle tube, the sealing cover includes a sealing cover body and a nozzle sealing hole with a blind end provided on the sealing cover body, and an annular sealing groove is arranged on the outer periphery of the nozzle sealing hole, The side wall of the annular sealing groove is provided with an annular sealing boss extending into the groove, the nozzle sealing hole is adapted to the nozzle tube and the conical spout, and the annular sealing groove is adapted to the annular retaining edge.
  • the beneficial effects of the present invention are that the structure of the present invention is compact and reasonable, the liquid discharge is stable, and it is suitable for automatic liquid taking of instruments.
  • FIG. 1 is a schematic structural diagram of the upper top surface of the kit.
  • FIG. 2 is a schematic structural diagram of the lower bottom surface of the kit.
  • FIG. 3 is a schematic structural diagram of an air inlet port.
  • FIG. 4 is a schematic structural diagram of a liquid outlet device.
  • FIG. 5 is a schematic view of the structure of the sealing cover.
  • a kit includes a box body 1-1, an air inlet 1-2 arranged on the side of the box body 1-1, a liquid outlet 1-3, and a box body 1-1.
  • the liquid port 1-3, the air inlet port 1-2 is connected with an air inlet port, and the liquid outlet port 1-3 is connected with a liquid outlet device.
  • the elongated flow channel includes a first flow channel 1-5 and a fourth flow channel 1-6 arranged on the bottom surface of the box body 1-1 and a second flow channel 1-7 arranged on the top surface of the box body 1-1. and the third flow channel 1-8, the first flow channel 1-5, the second flow channel 1-7, the third flow channel 1-8, and the fourth flow channel 1-6 are sequentially connected.
  • the first flow channel 1-5, the second flow channel 1-7 and the third flow channel 1-8 are all back-folded flow channels, and specifically, an S-shape connected end to end may be used.
  • the gas After the gas passes through the slender flow channel, the gas changes its direction and flows repeatedly, which can prolong the time for the gas to reach the liquid storage tank and ensure the uniform and stable pressure of the liquid storage tank, so as to make the liquid output stable and avoid the unstable pressure of the input gas at the air inlet.
  • a gas-liquid isolation trap is arranged between the liquid storage tank 1-4 and the elongated flow channel; the gas-liquid isolation trap includes a third flow channel 1-8 and a fourth flow channel 1-6.
  • the reagent in the liquid storage tank flows back to the slender flow channel, it will first be poured into the second trap tank through the fourth flow channel.
  • the second gas column is higher than the bottom surface of the second trap tank, and only the After the liquid level reaches a certain height, it will reach the top opening of the air column, and then continue to flow back into the third flow channel.
  • the first trap groove is connected to the third flow channel. As mentioned above, the liquid level needs to exceed the first air column to Continuing forward, reverse flow occurs, so the gas-liquid isolation trap prevents liquid from flowing back into the air intake.
  • the box body 1-1 is provided with an air intake silo 1-13 communicating with the air inlet 1-2, and the air intake silo 1-13 passes through the air storage silo 1- 14 communicates with the first flow channels 1-5.
  • the gas enters the air intake chamber from the air inlet and then enters the slender flow channel through the air storage chamber.
  • the air intake chamber and the air storage chamber play the role of the first pressure equalization.
  • the function of the overflow groove is also to further prevent the liquid reagent from continuing to flow backward.
  • the overflow groove 1-15 communicates with the second flow channel 1-7 through a third trap groove 1-16 arranged on the top surface of the box body 1-1, and the third trap groove 1-16 is provided with a third trap groove.
  • the overflow groove 1-15 communicates with the third trap groove 1-16 through the third air column 1-17.
  • the third trap here has the same function as the aforementioned first and second traps.
  • the second flow channel 1-7 communicates with the third flow channel 1-8 through a sponge groove 1-18 arranged on the top surface of the box body 1-1, and a water-absorbing sponge is arranged in the sponge groove 1-18.
  • the absorbent sponge can filter the gas, and at the same time, when the liquid reagent is sucked into the sponge tank, the absorbent sponge will absorb the liquid reagent to improve the anti-reflux effect.
  • the second trap tank 1-10 communicates with the liquid storage tank 1-4 through the connecting flow channel 1-19.
  • the connecting flow channel can improve the difficulty of liquid sucking back, and on the other hand, it can further play the role of gas pressure equalization.
  • the kit as shown in Figure 1 and Figure 2 there are two liquid storage tanks, which are respectively connected to the gas storage chamber through the same structure. Second, enter their respective runners.
  • the gas first enters the overflow groove from the first flow channel, and the overflow grooves can be a plurality of consecutive ones, and then enter the third trap groove through the third gas column after passing through the continuous overflow grooves.
  • the gas continues forward from the third trap groove, enters the sponge groove after passing through the second flow channel, and then enters the third flow channel from the sponge groove.
  • the third flow channel is connected to the first air column to introduce the gas into the first trap groove.
  • the gas then passes through the first trap groove through the fourth flow channel into the second gas column and enters the second trap groove, and finally communicates with the liquid storage tank through the connecting flow channel.
  • Each flow channel and compartment of the present invention are separated by arranging partitions inside the box body, the upper top surface or the lower bottom surface, and by covering the partitions with plastic sealing films, because the volume of the liquid storage tank is relatively large. , when the liquid is filled, the plastic film will be lifted up and bulged, so a support plate 1-20 is arranged in the liquid storage tank, and the top of the support plate is fixed with the plastic film.
  • the air inlet interface includes an air inlet connecting pipe 2-1 and a blocking pipe 2-2 arranged at one end of the air inlet connecting pipe 2-1, and the blocking pipe 2-2 has an interference fit inside.
  • a gas nozzle plug 2-3 is provided, and the gas nozzle plug 2-3 is provided with an air intake blind hole along the axis, and the open end of the air intake blind hole faces the air intake connecting pipe 2-1.
  • the air inlet connecting pipe 2-1 and the blocking pipe 2-2 are annular pipes, and the gas nozzle plug 2-3 is a cylinder.
  • a sealing boss 2-4 is provided on the outer side wall of the gas nozzle plug 2-3 along the circumferential direction. There are two sealing bosses 2-4.
  • the air inlet pipe is communicated with the air inlet 1-2 of the box body 1-1, and the air nozzle plug seals the blocking pipe to block the air inlet pipe from communicating with the outside world.
  • the air needle is pierced through the air nozzle plug to connect the air intake with the air intake connecting pipe.
  • the sealing boss presses the inner side wall of the blocking tube outward to achieve sealing.
  • the air inlet blind hole includes a frustoconical air inlet hole 2-5 and a cylindrical air inlet hole 2-6 which communicate with each other.
  • the cylindrical air inlet hole 2-6 has a blind end, and the frustoconical air inlet hole 2
  • the small bottom end of the -5 is connected with the cylindrical air intake hole 2-6, and the large bottom end of the frustoconical air intake hole 2-5 is an open end.
  • the diameter of the small bottom end of the frustoconical air inlet hole 2-5 is equal to the diameter of the cylindrical air inlet hole 2-6.
  • the tip of the gas needle pierces the middle of the gas nozzle plug, and after the gas needle passes through the blind end of the cylindrical air inlet hole, it enters the air inlet connection pipe from the cylindrical air inlet hole and the truncated cone-shaped air inlet hole.
  • the air inlet communicates with the cartridge air inlet.
  • the air inlet blind hole makes the middle thickness of the air nozzle plug thinner, and it is easy for the needle of the air needle to pierce in.
  • the cylindrical air intake hole is convenient for positioning during puncture, and the frustum-shaped air intake hole has a larger opening to avoid the left and right shaking of the gas needle during the puncture process. blocked. It should be noted that the outer circular portion of the valve plug cannot be thinned, which will degrade its sealing performance.
  • the liquid outlet device includes a nozzle and a nozzle disposed at the end of the nozzle.
  • the nozzle includes a nozzle main body 3-1, a nozzle hole 3-2 arranged in the axial direction of the nozzle main body 3-1, and a magnet bar 3-3 arranged in the nozzle hole 3-2.
  • the nozzle hole 3- The inner wall of 2 is evenly provided with a number of retaining bars 3-4 along the axial direction of the injection hole 3-2, and one end of each retaining bar 3-4 is provided with a shoulder 3-4 extending toward the center of the injection hole 3-2. 5.
  • the magnet bar 3-3 moves along the axial direction of the spray hole 3-2 in the space enclosed by the shoulder 3-5 and the stop bar 3-4.
  • the main body of the nozzle is fixedly connected with the reagent box, and the nozzle hole in the main body of the nozzle is communicated with the liquid outlet hole 1-3 of the box body 1-1 of the reagent box.
  • the end of the nozzle main body 3-1 where the shoulder 3-5 is located is the liquid inlet end, and the liquid reagent in the kit flows from the liquid inlet end into the nozzle holes of the nozzle main body.
  • the inner diameter of the circular section enclosed by the plurality of shoulders 3-5 is smaller than the outer diameter of the section of the magnet bar 3-3, and the inner diameter of the circular section enclosed by the plurality of bars 3-4 is larger than that of the magnet bar 3-3.
  • the shoulder blocks the movement of the magnet bar toward the liquid outlet of the reagent cartridge, preventing the magnet bar from blocking the liquid outlet.
  • An air groove is formed between adjacent bars, and the liquid reagent can flow in the nozzle hole through the air groove without being affected by the magnet bar.
  • the nozzle includes an annular sleeve 4-1, an end plate 4-2 disposed at one end of the annular sleeve 4-1, a nozzle pipe 4-3 disposed in the center of the end plate 4-2, and a nozzle pipe 4-3 disposed in the center of the end plate 4-2.
  • the conical spout 4-4 at the end of the nozzle pipe 4-3, the end plate 4-2 is also provided with an annular retaining edge 4-5 surrounding the outer circumference of the nozzle pipe 4-3.
  • the conical nozzle 2-4 is provided with a liquid channel 4-6 communicating with the inside of the annular sleeve 2-1, and an annular groove 4-7 is formed between the nozzle pipe 4-3 and the annular retaining edge 4-5.
  • the conical spout of the nozzle is designed with a conical surface to prevent the liquid from dripping.
  • the nozzle tube 4-3 is in the shape of a truncated cone or a cylinder, and the outer side of the nozzle tube is provided with an annular rib and an annular groove to prevent the slender nozzle tube from being damaged by external forces. Make the sealing cover not easy to fall off.
  • the annular sleeve 4-1 is clamped to the nozzle main body 3-1.
  • the nozzle main body 3-1 is provided with a connecting ring platform 3-7 on the outside of the other end opposite to the shoulder platform 3-5, and an annular boss 3-8 is arranged on the outer side of the connecting ring platform 3-7
  • the open end of the annular sleeve 4-1 is provided with an annular groove 4-8 which is matched with the annular boss 3-8.
  • the nozzle is matched with the annular boss on the main body of the nozzle, and the connecting ring is inserted into the annular sleeve, which is convenient and direct to install and not easy to fall off.
  • the liquid reagent is ejected from the liquid channel in the nozzle after passing through the liquid outlet of the kit and the nozzle.
  • a sealing valve is arranged in the annular sleeve 4-1. It includes a sealing valve body 5-1 and a cylindrical valve hole 5-2 arranged on the sealing valve body 5-1.
  • the bottom end of the valve hole 5-2 is provided with a frustum hole 5-3.
  • the hole 5-3 is coaxial with the valve hole 5-2, and the small bottom end of the frustum hole 5-3 communicates with the bottom end of the valve hole 5-2.
  • the sealing valve body 5-1 is a cylinder, and the material is an elastic sealing material, such as rubber, preferably silica gel.
  • the placement direction of the sealing valve is that the small bottom side of the conical hole is close to the nozzle, and the large bottom side of the conical hole is close to the nozzle.
  • the valve hole communicates the nozzle hole of the nozzle pipe and the liquid channel of the nozzle.
  • the connecting end of the nozzle body and the annular sleeve has no shoulder, and the magnet bar can interfere with the sealing valve.
  • the sealing valve is made of silicone material and has elasticity. After being squeezed by the magnet bar, the valve hole is blocked to achieve a sealing effect, thereby blocking the liquid reagent from entering the nozzle and achieving the effect of stopping the liquid discharge.
  • the conical hole in the sealing valve can store a part of the liquid reagent, which is used to infiltrate the nozzle and prevent the liquid from rapidly volatilizing and crystallizing at the conical nozzle and blocking the nozzle.
  • the magnet bar 3-3 is cylindrical. There are more than three stop bars 3-4, which are evenly distributed on the inner wall of the spray hole, preferably six. Too few bars (one or two) will cause the magnet bar to stick to the inner wall of the nozzle hole during the movement. Too many bars will make the air grooves between adjacent bars too narrow, which will cause the flow resistance to change. big.
  • an electromagnet can be set on the liquid inlet end of the nozzle body, and a permanent magnet ring can be set on the outside of the connecting ring of the nozzle body.
  • the permanent magnet ring and the magnet rod have opposite polarities to attract the magnet The rod blocks the nozzle and stops the liquid discharge.
  • the electromagnet is energized, the magnetic force of the electromagnet is greater than the magnetic force of the permanent magnet ring, the magnet bar is attracted to the liquid inlet end, the shoulder is against the magnet bar, and the liquid reagent enters the nozzle through the air tank and is discharged.
  • a sealing cover is provided on the outer side of the nozzle, which includes a sealing cover body 6-1 and a nozzle sealing hole with a blind end provided on the sealing cover body 6-1.
  • the outer periphery of the nozzle sealing hole is An annular sealing groove 6-2 is provided, and the side wall of the annular sealing groove 6-2 is provided with an annular sealing boss 6-3 extending into the groove.
  • the nozzle sealing hole is located at the center of the annular sealing groove 6-2.
  • the nozzle sealing hole includes a connecting hole 6-4 and a blind end hole 6-5.
  • the blind end holes 6-5 are truncated cones.
  • the connecting hole 6-4 is cylindrical.
  • the sealing cover body 6-1 is cylindrical.
  • the sealing cap is made of an elastomeric sealing material, such as rubber.
  • the sealing cover is integrally formed with a silicone material as a whole.
  • the cylindrical connecting hole 6-4 cooperates with the cylindrical nozzle pipe 4-3, and the frustum-shaped blind end hole cooperates with the conical nozzle 4-4 to realize the nozzle Seal the connection.
  • the annular sealing groove cooperates with the annular retaining edge, and the annular sealing boss in the annular sealing groove presses the annular retaining edge.
  • the sealing cover forms double sealing protection for the nozzle nozzle and the annular rib of the nozzle, which is not easy to leak liquid.
  • the annular sealing boss in the annular sealing groove and the annular rib of the nozzle are squeezed tightly, which not only ensures the tightness, And make the sealing cover not easy to fall off.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

本发明涉及一种试剂盒，其包括盒体、设置在盒体侧部的进气口、出液口以及设置在盒体上的储液槽；所述储液槽的一端通过细长流道与进气口连通，所述储液槽的另一端连通有出液口，所述进气口连通有进气接口，所述出液口连通有出液装置。本发明结构紧凑，出液稳定，适合自动化取液。

Description

试剂盒 技术领域
本发明涉及一种试剂盒。
 背景技术
试剂盒是实验室常见的实验用品，用于反应试剂的保存。现在实验室和检测仪器使用试剂都是采用移液器或注射器将试剂从试剂盒抽出使用，抽取不同的试剂时还需要更换移液器吸头，或需要清洗注射器及针头，操作繁琐，浪费时间，抽取的量容易受到操作人操作手法的影响，不利于转化为自动化仪器进行操作。
 技术问题
本发明的目的是提供一种结构紧凑，适合自动化取液的试剂盒。
 技术解决方案
本发明采用如下技术方案：
一种试剂盒，其包括盒体、设置在盒体侧部的进气口、出液口以及设置在盒体上的储液槽；所述储液槽的一端通过细长流道与进气口连通，所述储液槽的另一端连通有出液口，所述进气口连通有进气接口，所述出液口连通有出液装置。
进一步的，所述细长流道包括设置在盒体下底面的第一流道和第四流道以及设置在盒体上顶面的第二流道和第三流道，所述第一流道、第二流道、第三流道、第四流道依次连通；所述储液槽与细长流道之间设置有气液隔离陷阱；
所述气液隔离陷阱包括设置第三流道与第四流道之间的第一陷阱槽以及设置在第四流道与储液槽之间的第二陷阱槽，所述第一陷阱槽内设置有第一气柱、所述第二陷阱槽内设置有第二气柱，所述第三流道通过第一气柱连通第一陷阱槽，所述第四流道通过第二气柱连通第二陷阱槽。
进一步的，所述进气接口包括与进气口连通的进气连接管以及设置在进气连接管另一端的封堵管，所述封堵管内过盈配合设置有气嘴塞，所述气嘴塞沿轴线设置有进气盲孔，所述进气盲孔的开口端朝向进气连接管。
进一步的，所述进气盲孔包括相互连通的锥台形进气孔以及圆柱形进气孔，所述圆柱形进气孔具有盲端，所述锥台形进气孔的小底端与圆柱形进气孔连接，所述锥台形进气孔的大底端为开口端。
进一步的，所述出液装置包括与出液口连接的喷管以及设置在喷管端部的喷嘴；
所述喷管包括喷管主体、沿喷管主体轴向设置的喷孔以及设置在喷孔内的磁铁棒，所述喷孔的内壁上均匀设置有若干个沿喷孔轴向的档条，每个所述档条的一端设置有向喷孔中心延伸的肩台，所述磁铁棒在由肩台和档条围合的空间内沿喷孔的轴向移动。
进一步的，所述喷嘴包括环形套管、设置在环形套管一端的端板、设置在端板中心的喷嘴管以及设置在喷嘴管端部的锥形喷口，所述端板上还设置有环绕在喷嘴管外周的环形档边，所述喷嘴管与锥形喷口内设置有与环形套管内部连通的液体通道，所述喷嘴管与环形档边之间围合形成环形沟槽；所述环形套管与喷管主体螺纹连接或卡接。
进一步的，所述环形套管内设置有密封阀；所述密封阀包括密封阀主体以及设置在密封阀主体上的圆柱形阀孔，所述阀孔的底端设置有锥台孔，所述锥台孔与阀孔同轴设置，所述锥台孔的小底一端与阀孔的底端连通；所述阀孔与喷孔相连通，所述锥台孔与液体通道连通。
进一步的，所述喷嘴管外设置有密封盖，所述密封盖包括密封盖本体以及设置在密封盖本体上的带有盲端的喷嘴密封孔，所述喷嘴密封孔的外周设置有环形密封槽，所述环形密封槽的侧壁设置有向槽内延伸的环形密封凸台，所述喷嘴密封孔与喷嘴管以及锥形喷口相适配，所述环形密封槽与环形档边相适配。
 有益效果
本发明的有益效果在于，本发明的结构紧凑、合理，出液稳定，适用于仪器自动化取液。
 附图说明
图1为试剂盒的上顶面的结构示意图。
图2为试剂盒的下底面的结构示意图。
图3为进气接口的结构示意图。
图4为出液装置的结构示意图。
图5为密封盖的结构示意图。
 本发明的实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整的描述。
如图1和图2所示，一种试剂盒，其包括盒体1-1、设置在盒体1-1侧部的进气口1-2、出液口1-3以及设置在盒体1-1上的储液槽1-4；所述储液槽1-4的一端通过细长流道与进气口1-2连通，所述储液槽1-4的另一端连通有出液口1-3，所述进气口1-2连通有进气接口，所述出液口1-3连通有出液装置。
所述细长流道包括设置在盒体1-1下底面的第一流道1-5和第四流道1-6以及设置在盒体1-1上顶面的第二流道1-7和第三流道1-8，所述第一流道1-5、第二流道1-7、第三流道1-8、第四流道1-6依次连通。所述第一流道1-5、第二流道1-7和第三流道1-8均为回折形流道，具体可采用首尾相连的S形。气体经细长流道后，气体经反复变向流动，可延长气体到达储液槽的时间同时保证储液槽的压力均匀稳定，从而使得出液稳定，避免进气口输入气体的压力不稳造成的出液流量不稳定的问题。
所述储液槽1-4与细长流道之间设置有气液隔离陷阱；所述气液隔离陷阱包括设置在第三流道1-8与第四流道1-6之间的第一陷阱槽1-9以及设置在第四流道1-6与储液槽1-4之间的第二陷阱槽1-10，所述第一陷阱槽1-9内设置有第一气柱1-11，所述第二陷阱槽1-10内设置有第二气柱1-12，所述第三流道1-8通过第一气柱1-11连通第一陷阱槽1-9，所述第四流道1-6通过第二气柱1-12连通第二陷阱槽1-10。一旦储液槽内的试剂倒流回细长流道，首先会通过第四流道灌入第二陷阱槽内，此时第二气柱高于第二陷阱槽的底面，只有第二陷阱槽内的液面到达一定高度后才会到达气柱的顶部开口，进而继续倒流入第三流道，第一陷阱槽与第三流道连通，如前所述，液面需要超过第一气柱才会继续向前发生倒流，因此，气液隔离陷阱可避免液体倒流回进气口。
所述盒体1-1上设置有与进气口1-2连通的进气仓1-13，所述进气仓1-13通过设置在盒体1-1下底面的储气仓1-14连通第一流道1-5。气体由进气口进入进气仓再经储气仓进入细长流道，进气仓和储气仓起到第一次均压的作用。
所述第一流道1-5与第二流道1-7之间通过设置在盒体1-1下底面的溢流槽1-15连通。溢流槽的作用同样是进一步避免液体试剂继续向前倒流。
所述溢流槽1-15通过设置在盒体1-1上顶面的第三陷阱槽1-16与第二流道1-7连通，所述第三陷阱槽1-16内设置有第三气柱1-17，所述溢流槽1-15通过第三气柱1-17连通第三陷阱槽1-16。此处的第三陷阱与前述第一和第二陷阱的功能相同。
所述第二流道1-7通过设置在盒体1-1上顶面的海绵槽1-18与第三流道1-8连通，所述海绵槽1-18内设置有吸水海绵。吸水海绵可以过滤气体，同时，当液体试剂倒吸入海绵槽时，吸水海绵会吸收液体试剂，提高防回流效果。
所述第二陷阱槽1-10通过连接流道1-19连通储液槽1-4。连接流道一方面可以提高液体倒吸的难度，另一方面可以进一步起到气体均压的作用。
对于如图1和图2所示的试剂盒，其储液槽为两个，其分别通过相同的结构与储气仓连接，气体由进气口经进气仓进入储气仓后一分为二，分别进入各自的流道。气体首先由第一流道进入溢流槽，溢流槽可以为多个连续，经连续的溢流槽后通过第三气柱进入第三陷阱槽。气体由第三陷阱槽继续向前，经第二流道后进入海绵槽，再由海绵槽进入第三流道，第三流道连通第一气柱将气体引入第一陷阱槽内。气体再由第一陷阱槽经第四流道通入第二气柱进入第二陷阱槽，最终由连接流道与储液槽连通。
当然，储液槽也可以是多个，分别经相同结构与储气仓连接，细长流道以及气液隔离陷阱的设置有效避免回流的发生，即便发生回流，多种试剂也难以相互混合，实现一个试剂盒储存多种试剂的效果。
本发明的各个流道和隔仓均是通过在盒体内部、上顶面或下底面设置隔板分隔而成，在通过在隔板上覆盖塑封膜而成，由于储液槽的容积较大，在充入液体时会将塑封膜顶起而鼓包，因而在储液槽内设置有支撑板1-20，支撑板的顶部与塑封膜固定。
如图3所示，所述进气接口包括进气连接管2-1以及设置在进气连接管2-1一端的封堵管2-2，所述封堵管2-2内过盈配合设置有气嘴塞2-3，所述气嘴塞2-3沿轴线设置有进气盲孔，所述进气盲孔的开口端朝向进气连接管2-1。
所述进气连接管2-1和封堵管2-2为环形管，所述气嘴塞2-3为圆柱体。所述气嘴塞2-3的外侧壁沿周向设置有密封凸台2-4。所述密封凸台2-4为两条。
所述进气管与盒体1-1的进气口1-2连通，气嘴塞将封堵管封堵，阻断进气管与外界连通。使用时将气针刺穿气嘴塞，使进气与进气连接管连通。密封凸台向外挤压封堵管的内侧壁，实现密封。
所述进气盲孔包括相互连通的锥台形进气孔2-5以及圆柱形进气孔2-6，所述圆柱形进气孔2-6具有盲端，所述锥台形进气孔2-5的小底端与圆柱形进气孔2-6连接，所述锥台形进气孔2-5的大底端为开口端。所述锥台形进气孔2-5的小底端的直径与圆柱形进气孔2-6的直径相等。
气针穿刺时，气针的尖端刺入气嘴塞的中部，气针穿过圆柱形进气孔的盲端后，由圆柱形进气孔和锥台形进气孔进入进气连接管，完成进气与试剂盒进气口的连通。进气盲孔使气嘴塞的中间厚度变薄，容易使气针的针头穿刺进去。圆柱形进气孔方便进行穿刺时的定位，锥台形进气孔的开口较大，避免穿刺过程中气针的左右晃动造成气针针头插入到进气盲孔的侧壁上，造成气针的堵塞。应注意的是，气嘴塞的外圆部分不能变薄，这会使其密封性能下降。
如图4所示，所述出液装置包括喷管以及设置在喷管端部的喷嘴。
所述喷管包括喷管主体3-1、沿喷管主体3-1轴向设置的喷孔3-2以及设置在喷孔3-2内的磁铁棒3-3，所述喷孔3-2的内壁上均匀设置有若干个沿喷孔3-2轴向的档条3-4，每个所述档条3-4的一端设置有向喷孔3-2中心延伸的肩台3-5，所述磁铁棒3-3在由肩台3-5和档条3-4围合的空间内沿喷孔3-2的轴向移动。
喷管主体与试剂盒固定连接，喷管主体内的喷孔与试剂盒盒体1-1的出液孔1-3相连通。所述喷管主体3-1中肩台3-5所处的一端为进液端，试剂盒内的液体试剂从进液端流入喷管主体的喷孔中。
若干个所述肩台3-5围合的圆形截面内径小于磁铁棒3-3的截面外径，若干个所述档条3-4围合的圆形截面内径大于磁铁棒3-3的截面外径。肩台可阻挡磁铁棒向试剂盒的出液孔移动，以防止磁铁棒封堵出液口。相邻档条之间形成气槽，液体试剂可通过气槽在喷孔内流动而不受磁铁棒的影响。
如图4所示，所述喷嘴包括环形套管4-1、设置在环形套管4-1一端的端板4-2、设置在端板4-2中心的喷嘴管4-3以及设置在喷嘴管4-3端部的锥形喷口4-4，所述端板4-2上还设置有环绕在喷嘴管4-3外周的环形档边4-5，所述喷嘴管2-3与锥形喷口2-4内设置有与环形套管2-1内部连通的液体通道4-6，所述喷嘴管4-3与环形档边4-5之间围合形成环形沟槽4-7。
喷嘴的锥形喷口处为锥面设计，防止液体挂滴。所述喷嘴管4-3为锥台形或圆柱形，喷嘴管外侧有环形档边和环形沟槽，防止细长喷嘴管被外力破坏，沟槽还可以在安装密封盖时，卡住密封盖，使密封盖不易脱落。
所述环形套管4-1与喷管主体3-1卡接。具体的，所述喷管主体3-1在与肩台3-5相对的另一端外侧设置有连接环台3-7，所述连接环台3-7的外侧设置有环形凸台3-8，所述环形套管4-1的开口端设置有与所述环形凸台配合3-8的环形凹槽4-8。喷嘴与喷管主体上的环形凸台相配合，连接环台插入环形套管内，安装方便直接，不易脱落。液体试剂经试剂盒的出液口和喷管后，由喷嘴内的液体通道喷出。
所述环形套管4-1内设置有密封阀。其包括密封阀主体5-1以及设置在密封阀主体5-1上的圆柱形阀孔5-2，所述阀孔5-2的底端设置有锥台孔5-3，所述锥台孔5-3与阀孔5-2同轴设置，所述锥台孔5-3的小底一端与阀孔5-2的底端连通。所述密封阀主体5-1为圆柱体，材料选用弹性密封材料，如橡胶，优选为硅胶。
密封阀的放置方向为锥形孔的小底一侧靠近喷管，锥形孔的大底一侧靠近喷嘴，密封阀主体与环形套管过盈配合，实现密封，防止液体从缝隙处漏出。阀孔将喷管的喷孔以及喷嘴的液体通道连通。喷管主体与环形套管的连接端并无肩台，磁铁棒可以抵触密封阀。密封阀为硅胶材料，具有弹性，受磁铁棒挤压后，阀孔被堵住，达到密封作用，从而阻断液体试剂进入喷嘴中，达到停止出液的效果。
密封阀中的锥形孔可存储一部分液体试剂，用来浸润喷嘴，防止锥形喷口处液体快速挥发结晶而堵塞喷嘴。
所述磁铁棒3-3为圆柱形。所述档条3-4为三个以上，均匀分布在喷孔内壁上，优选为6个。档条的数量过少（一个或两个）会导致磁铁棒在运动过程中贴在喷孔内壁上，过多则会使相邻的档条间的气槽过窄，均会造成流动阻力变大。
为了实现磁铁棒在喷孔内的运动，可以在喷管主体的进液端外套装电磁铁，喷管主体的连接环台外套置永磁铁圈，永磁铁圈与磁铁棒极性相反，吸引磁铁棒封堵喷嘴，停止出液。当需要排出液体时，电磁铁通电，电磁铁的磁力大于永磁铁圈的磁力，磁铁棒被吸引至进液端，肩台抵住磁铁棒，液体试剂通过气槽进入喷嘴后排出。
如图5所示，所述喷嘴外侧配合设置有密封盖，其包括密封盖本体6-1以及设置在密封盖本体6-1上的带有盲端的喷嘴密封孔，所述喷嘴密封孔的外周设置有环形密封槽6-2，所述环形密封槽6-2的侧壁设置有向槽内延伸的环形密封凸台6-3。所述喷嘴密封孔位于环形密封槽6-2的中心处。
所述喷嘴密封孔包括连接孔6-4以及盲端孔6-5。所述盲端孔6-5为锥台形。所述连接孔6-4为圆柱形。所述密封盖本体6-1为圆柱形。所述密封盖由弹性体密封材料制得，如橡胶。优选的，所述密封盖整体采用硅胶材质一体成型。
当喷嘴与密封盖组合实现密封时，圆柱形的连接孔6-4与圆柱形的喷嘴管4-3进行配合，锥台形的盲端孔与锥形喷口4-4与进行配合，实现喷嘴的密封连接。所述环形密封槽与环形档边相互配合，环形密封槽内的环形密封凸台压紧环形档边。密封盖对喷嘴的喷口及喷嘴的环形档边形成双重密封保护，不易漏液，另外，在环形密封槽内的环形密封凸台与喷嘴的环形档边挤压过盈，既保证了密封性，又使密封盖不易脱落。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (8)

  1. 一种试剂盒，其特征在于，其包括盒体（1-1）、设置在盒体（1-1）侧部的进气口（1-2）、出液口（1-3）以及设置在盒体（1-1）上的储液槽（1-4）；所述储液槽（1-4）的一端通过细长流道与进气口（1-2）连通，所述储液槽（1-4）的另一端连通有出液口（1-3），所述进气口（1-2）连通有进气接口，所述出液口（1-3）连通有出液装置。
  2. 根据权利要求1所述的一种试剂盒，其特征在于，所述细长流道包括设置在盒体（1-1）下底面的第一流道（1-5）和第四流道（1-6）以及设置在盒体（1-1）上顶面的第二流道（1-7）和第三流道（1-8），所述第一流道（1-5）、第二流道（1-7）、第三流道（1-8）、第四流道（1-6）依次连通；所述储液槽（1-4）与细长流道之间设置有气液隔离陷阱；
    所述气液隔离陷阱包括设置在第三流道（1-8）与第四流道（1-6）之间的第一陷阱槽（1-9）以及设置在第四流道（1-6）与储液槽（1-4）之间的第二陷阱槽（1-10），所述第一陷阱槽（1-9）内设置有第一气柱（1-11），所述第二陷阱槽（1-10）内设置有第二气柱（1-12），所述第三流道（1-8）通过第一气柱（1-11）连通第一陷阱槽（1-9），所述第四流道（1-6）通过第二气柱（1-12）连通第二陷阱槽（1-10）。
  3. 根据权利要求1所述的一种试剂盒，其特征在于，所述进气接口包括与进气口（1-2）连通的进气连接管（2-1）以及设置在进气连接管（2-1）另一端的封堵管（2-2），所述封堵管（2-2）内过盈配合设置有气嘴塞（2-3），所述气嘴塞（2-3）沿轴线设置有进气盲孔，所述进气盲孔的开口端朝向进气连接管（2-1）。
  4. 根据权利要求3所述的一种试剂盒，其特征在于，所述进气盲孔包括相互连通的锥台形进气孔（2-5）以及圆柱形进气孔（2-6），所述圆柱形进气孔（2-6）具有盲端，所述锥台形进气孔（2-5）的小底端与圆柱形进气孔（2-6）连接，所述锥台形进气孔（2-5）的大底端为开口端。
  5. 根据权利要求1所述的一种试剂盒，其特征在于，所述出液装置包括与出液口（1-3）连接的喷管以及设置在喷管端部的喷嘴；
    所述喷管包括喷管主体（3-1）、沿喷管主体（3-1）轴向设置的喷孔（3-2）以及设置在喷孔（3-2）内的磁铁棒（3-3），所述喷孔（3-2）的内壁上均匀设置有若干个沿喷孔（3-2）轴向的档条（3-4），每个所述档条（3-4）的一端设置有向喷孔（3-2）中心延伸的肩台（3-5），所述磁铁棒（3-3）在由肩台（3-5）和档条（3-4）围合的空间内沿喷孔（3-2）的轴向移动。
  6. 根据权利要求5所述的一种试剂盒，其特征在于，所述喷嘴包括环形套管（4-1）、设置在环形套管（4-1）一端的端板（4-2）、设置在端板（4-2）中心的喷嘴管（4-3）以及设置在喷嘴管（4-3）端部的锥形喷口（4-4），所述端板（4-2）上还设置有环绕在喷嘴管（4-3）外周的环形档边（4-5），所述喷嘴管（4-3）与锥形喷口（4-4）内设置有与环形套管（4-1）内部连通的液体通道（4-6），所述喷嘴管（4-3）与环形档边（4-5）之间围合形成环形沟槽（4-7）；
    所述环形套管（4-1）与喷管主体（3-1）螺纹连接或卡接。
  7. 根据权利要求6所述的一种试剂盒，其特征在于，所述环形套管（4-1）内设置有密封阀；所述密封阀包括密封阀主体（5-1）以及设置在密封阀主体（5-1）上的圆柱形阀孔（5-2），所述阀孔（5-2）的底端设置有锥台孔（5-3），所述锥台孔（5-3）与阀孔（5-2）同轴设置，所述锥台孔（5-3）的小底一端与阀孔（5-2）的底端连通；所述阀孔（5-2）与喷孔（3-2）相连通，所述锥台孔（5-3）与液体通道（4-6）连通。
  8. 根据权利要求6所述的一种试剂盒，其特征在于，所述喷嘴管外设置有密封盖，所述密封盖包括密封盖本体（6-1）以及设置在密封盖本体（6-1）上的带有盲端的喷嘴密封孔，所述喷嘴密封孔的外周设置有环形密封槽（6-2），所述环形密封槽（6-2）的侧壁设置有向槽内延伸的环形密封凸台（6-3），所述喷嘴密封孔与喷嘴管（4-3）以及锥形喷口（4-4）相适配，所述环形密封槽（6-2）与环形档边（4-5）相适配。
     
PCT/CN2021/117656 2020-11-23 2021-09-10 试剂盒 WO2022105383A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202011317091.3 2020-11-23
CN202011317091.3A CN112526153A (zh) 2020-11-23 2020-11-23 试剂盒

Publications (1)

Publication Number Publication Date
WO2022105383A1 true WO2022105383A1 (zh) 2022-05-27

Family

ID=74992498

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2021/117656 WO2022105383A1 (zh) 2020-11-23 2021-09-10 试剂盒

Country Status (2)

Country Link
CN (1) CN112526153A (zh)
WO (1) WO2022105383A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112520182A (zh) * 2020-11-23 2021-03-19 石家庄禾柏生物技术股份有限公司 一种试剂盒进气结构
CN112455872A (zh) * 2020-11-23 2021-03-09 石家庄禾柏生物技术股份有限公司 一种带有气液隔离陷阱的试剂盒
CN112429399A (zh) * 2020-11-23 2021-03-02 石家庄禾柏生物技术股份有限公司 一种密封盖
CN112526153A (zh) * 2020-11-23 2021-03-19 石家庄禾柏生物技术股份有限公司 试剂盒
CN112547329A (zh) * 2020-11-23 2021-03-26 石家庄禾柏生物技术股份有限公司 一种试剂盒出液装置
CN115217670B (zh) * 2022-05-24 2024-04-26 中国民用航空飞行学院 一种三涵道超声速喷管构型的设计方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106226545A (zh) * 2016-07-06 2016-12-14 苏州大学 具有可编程进样功能的微流控三维芯片
CN111175528A (zh) * 2019-12-19 2020-05-19 石家庄禾柏生物技术股份有限公司 一种新型试剂添加系统
CN111308111A (zh) * 2019-12-20 2020-06-19 石家庄禾柏生物技术股份有限公司 一种试剂盒
CN111308110A (zh) * 2019-12-19 2020-06-19 石家庄禾柏生物技术股份有限公司 一种新型试剂盒
CN111351940A (zh) * 2020-02-21 2020-06-30 南京岚煜生物科技有限公司 一种新型冠状病毒IgG检测试剂、试剂卡、试剂盒及其制备方法
CN112455872A (zh) * 2020-11-23 2021-03-09 石家庄禾柏生物技术股份有限公司 一种带有气液隔离陷阱的试剂盒
CN112526153A (zh) * 2020-11-23 2021-03-19 石家庄禾柏生物技术股份有限公司 试剂盒

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106226545A (zh) * 2016-07-06 2016-12-14 苏州大学 具有可编程进样功能的微流控三维芯片
CN111175528A (zh) * 2019-12-19 2020-05-19 石家庄禾柏生物技术股份有限公司 一种新型试剂添加系统
CN111308110A (zh) * 2019-12-19 2020-06-19 石家庄禾柏生物技术股份有限公司 一种新型试剂盒
CN111308111A (zh) * 2019-12-20 2020-06-19 石家庄禾柏生物技术股份有限公司 一种试剂盒
CN111351940A (zh) * 2020-02-21 2020-06-30 南京岚煜生物科技有限公司 一种新型冠状病毒IgG检测试剂、试剂卡、试剂盒及其制备方法
CN112455872A (zh) * 2020-11-23 2021-03-09 石家庄禾柏生物技术股份有限公司 一种带有气液隔离陷阱的试剂盒
CN112526153A (zh) * 2020-11-23 2021-03-19 石家庄禾柏生物技术股份有限公司 试剂盒

Also Published As

Publication number Publication date
CN112526153A (zh) 2021-03-19

Similar Documents

Publication Publication Date Title
WO2022105383A1 (zh) 试剂盒
JP3130132B2 (ja) 加圧液体の微生物試験のための方法及び装置
CN204177629U (zh) 一种便捷式采液器
JP4639371B2 (ja) 微生物学的解析組立体および方法
CN106902902B (zh) 一种微流体芯片进样系统及适配管
WO2023221392A1 (zh) 一种粪便取样检测装置
CN214201511U (zh) 试剂盒
US11779941B2 (en) Sealing valve, and liquid outlet structure comprising same
US10677811B2 (en) Sample receptacle, sample container and method of use
JP2023041884A (ja) 生体液試料を回収する方法および生体液回収デバイス
CN112986603A (zh) 一种抗原检测防漏试剂滴管及生物采样方法
WO2022105388A1 (zh) 一种试剂盒出液装置
CN108729143A (zh) 一种洗涤添加剂盒安装结构
WO2020088222A1 (zh) 流体控制结构与微流控芯片及芯片操作方法
CN214622701U (zh) 一种抗原检测防漏试剂滴管
CN202070211U (zh) 一种封闭/开放兼用的无菌检查薄膜过滤器
WO2021004298A1 (zh) 净水装置
CN213590513U (zh) 一种新式尿沉渣试管
CN215110524U (zh) 一种包含密封阀的出液结构
CN214373536U (zh) 一种采样管
CN214106781U (zh) 一种混合头
CN203929724U (zh) 一次性钳口色谱过滤进样瓶
CN216987746U (zh) 一种可拆卸式乳化沥青存储稳定性试管
LU500082B1 (en) A device for culturing animal muscle cells
CN214637399U (zh) 一种试剂盒出液装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21893534

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21893534

Country of ref document: EP

Kind code of ref document: A1