WO2022103064A1 - Composition comprenant une hormone de libération de la corticotropine en tant que principe actif pour favoriser la formation de neurosphères - Google Patents
Composition comprenant une hormone de libération de la corticotropine en tant que principe actif pour favoriser la formation de neurosphères Download PDFInfo
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- YNJORDSKPXMABC-UHFFFAOYSA-N sodium;2-hydroxypropane-2-sulfonic acid Chemical compound [Na+].CC(C)(O)S(O)(=O)=O YNJORDSKPXMABC-UHFFFAOYSA-N 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000009168 stem cell therapy Methods 0.000 description 1
- 238000002660 stem cell treatment Methods 0.000 description 1
- 238000009580 stem-cell therapy Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 210000003242 unipolar neuron Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/85—Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C12N2501/855—Corticotropin [ACTH]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system
Definitions
- the present invention provides a kit for forming nerve cell cells, comprising corticotropin-releasing hormone (CRH) as an active ingredient.
- CHL corticotropin-releasing hormone
- the composition may be a composition for adding a medium, but is not limited thereto.
- the kit according to the present invention may include instructions describing the procedure for carrying out the above-described method according to the present invention.
- cellular therapeutic agent refers to cells and tissues isolated from humans, cultured, and manufactured through special manipulation, and is a drug (US FDA regulations) used for the purpose of treatment, diagnosis, and prevention. Or through a series of actions such as proliferating and selecting living autologous, allogeneic, or xenogeneic cells in vitro or changing the biological properties of cells in other ways to restore tissue function, these cells can be used in the treatment, diagnosis and prevention of diseases. Drugs used for that purpose.
- composition may be administered by any device capable of transporting a cell therapy agent to a target cell.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Developmental Biology & Embryology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne une composition comprenant une hormone de libération de la corticotropine comme principe actif pour favoriser la formation de neurosphères. Les présents inventeurs proposent une technique de formation d'une neurosphère, qui est un groupe de cellules souches neurales, à l'aide de CRH. Ils ont identifié que, non seulement les neurosphères peuvent être simplement formées mais que le nombre et la taille de neurosphères peuvent également être augmentés en ajoutant uniquement de la CRH. Un grand nombre de neurosphères peut être fixé à l'aide de la CRH. Le résultat escompté serait de pouvoir utiliser par la suite les cellules souches neuronales produites pour traiter efficacement des troubles neurodégénératifs.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200151491A KR102551880B1 (ko) | 2020-11-13 | 2020-11-13 | 부신피질자극호르몬분비호르몬을 유효성분으로 포함하는 신경세포구 형성 촉진용 조성물 |
| KR10-2020-0151491 | 2020-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022103064A1 true WO2022103064A1 (fr) | 2022-05-19 |
Family
ID=81601501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2021/015834 WO2022103064A1 (fr) | 2020-11-13 | 2021-11-04 | Composition comprenant une hormone de libération de la corticotropine en tant que principe actif pour favoriser la formation de neurosphères |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR102551880B1 (fr) |
| WO (1) | WO2022103064A1 (fr) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030186867A1 (en) * | 2000-03-31 | 2003-10-02 | Laura Facci | Use of crf receptor agonists for the treatment or prophylaxis of diseases, for example neurodegenerative diseases |
| KR20070042546A (ko) * | 2004-07-08 | 2007-04-23 | 아임스코 리미티드 | 약제 |
| KR20080026786A (ko) * | 2006-09-21 | 2008-03-26 | 부산대학교 산학협력단 | 피부 유래 줄기세포를 함유하는 신경질환 치료용세포치료제 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007320031B2 (en) | 2006-10-06 | 2013-05-02 | University Of Virginia Patent Foundation | Methods and compositions useful for diabetic wound healing |
| US9480695B2 (en) | 2011-09-29 | 2016-11-01 | The University Of Tokyo | Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder |
-
2020
- 2020-11-13 KR KR1020200151491A patent/KR102551880B1/ko active IP Right Grant
-
2021
- 2021-11-04 WO PCT/KR2021/015834 patent/WO2022103064A1/fr active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030186867A1 (en) * | 2000-03-31 | 2003-10-02 | Laura Facci | Use of crf receptor agonists for the treatment or prophylaxis of diseases, for example neurodegenerative diseases |
| KR20070042546A (ko) * | 2004-07-08 | 2007-04-23 | 아임스코 리미티드 | 약제 |
| KR20080026786A (ko) * | 2006-09-21 | 2008-03-26 | 부산대학교 산학협력단 | 피부 유래 줄기세포를 함유하는 신경질환 치료용세포치료제 |
Non-Patent Citations (2)
| Title |
|---|
| KOUTMANI Y, GAMPIERAKIS IA, POLISSIDIS A, XIMERAKIS M, KOUTSOUDAKI PN, POLYZOS A, AGROGIANNIS G, KARALIOTA S, THOMAIDOU D, RUBIN : "CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus", CELL REPORTS, vol. 29, no. 4, 22 October 2019 (2019-10-22), pages 932 - 945.e7, XP055932108, DOI: 10.1016/j.celrep.2019.09.037 * |
| SUGA HIDETAKA: "Differentiation of Pluripotent Stem Cells into Hypothalamic and Pituitary Cells", NEUROENDOCRINOLOGY, vol. 101, no. 1, 2 April 2015 (2015-04-02), S.KARGER, BASEL., CH, pages 18 - 24, XP055932103, ISSN: 0028-3835, DOI: 10.1159/000369821 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220065216A (ko) | 2022-05-20 |
| KR102551880B1 (ko) | 2023-07-05 |
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