WO2022099959A1

WO2022099959A1 - Cleaning station structure for preventing liquid hanging from sampling needle

Info

Publication number: WO2022099959A1
Application number: PCT/CN2021/081005
Authority: WO
Inventors: 吴国银; 胡统号; 吴冬
Original assignee: 苏州长光华医生物医学工程有限公司
Priority date: 2020-11-13
Filing date: 2021-03-16
Publication date: 2022-05-19
Also published as: CN112547699B; CN112547699A

Abstract

A cleaning structure for preventing liquid hanging from a sampling needle, the cleaning structure comprising an upper body (1), a middle body (2), a lower body (3), a system liquid connector (4) and a reinforced cleaning liquid connector (5). The upper body (1) comprises first threaded holes (11) and a small cavity hole (12), the first threaded holes (11) are formed on two side surfaces of the upper body (1), the small cavity hole (12) is formed on an inner side of the upper body (1), two air holes (13) are symmetrically formed on two sides of the small cavity hole (12) and on the inner side of the upper body (1), and through holes (131) are provided at the positions where the two air holes (13) penetrate the small cavity hole (12). The cleaning structure for preventing liquid hanging from a sampling needle can effectively prevent liquid hanging from a needle tip after cleaning, has a good cleaning effect and a high cleaning efficiency, reduces the usage amount of the cleaning liquid, saves on time and labor, and has a good working effect.

Description

A cleaning station structure that avoids liquid hanging on sampling needles

technical field

The invention relates to the technical field of cleaning structures, in particular to a cleaning structure for avoiding liquid hanging on a sampling needle.

Background technique

In the fully automatic chemiluminescence immunoassay analyzer, after the reagent needle and the sample needle are loaded, in order to avoid the interaction between different samples and reagents, when the next sample is collected or the next reagent is added, the sample needle needs to be adjusted. Cleaning, whether cleaning is clean or not directly affects the experimental results.

At present, the sample needle or reagent needle is usually cleaned by water column flushing. The cleaning method of flushing the needle tip by water column has the following defects:

(1) It is necessary to accurately adjust the relative position of the needle tip and the water column to ensure that the needle tip and the area above (the part immersed in the sample or reagent during sampling) are fully wrapped by the water column to ensure cleaning, which increases the difficulty of coordinate debugging;

(2) When the needle tip is flushed with one side of the water column, the needle tip on the opposite side of the water column cannot be effectively flushed, and the flushing effect is poor, resulting in occasional unclean cleaning;

(3) It takes a long time to flush the needle tip, the flushing efficiency is poor, the cleaning solution is wasted, and the cleaning time is long;

(4) Water column flushing, the water flow is unstable, and the needle tip hangs seriously after cleaning.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a cleaning structure that avoids liquid hanging on the sampling needle in order to solve the above problems.

The present invention realizes above-mentioned purpose through following technical scheme:

A cleaning structure for avoiding liquid hanging on a sampling needle, comprising an upper body, a middle body, a lower body, a system liquid joint, a strengthening cleaning liquid joint, an air flow joint, and a waste liquid joint;

Small cavity holes are formed on the inner side of the upper body, air holes are formed on both sides of the small cavity holes and on the inner side of the upper body, the air holes are communicated with the small cavity holes, and the lower part of the small cavity holes is formed. and a large cavity hole is formed on the inner side of the upper body, the top of the large cavity hole is formed with a dome, and the air hole is connected with an air flow joint;

The middle body is installed under the upper body, the middle body includes a cleaning pool, the cleaning pool is communicated with the large cavity, the bottom of the cleaning pool is formed with a spherical bottom, and the bottom of the middle body is formed. A first waste liquid collection cavity is formed inside, the upper edge of the cleaning tank adjacent to the first waste liquid collection cavity is formed with a diversion notch, and the outer side of the cleaning tank is provided with a waste liquid collection hole. The waste liquid collection hole is connected to the first waste liquid collection cavity, and the system liquid joint and the enhanced cleaning liquid joint are installed on the middle body;

The lower body is installed below the middle body, the inner side of the lower body is formed with a second waste liquid collection cavity, and the lower body is connected with a waste liquid joint.

Preferably, a cleaning structure of the present invention for avoiding liquid hanging on the sampling needle is characterized in that:

Both sides of the upper body are formed with first threaded holes, and the air flow joints are connected through the first threaded holes;

A second threaded hole is formed on the side of the middle body, the second threaded hole penetrates the cleaning pool, and a third threaded hole is formed on the other side of the middle body, and the third threaded hole penetrates the cleaning pool a tank, the system fluid connector is installed on the second threaded hole, and the enhanced cleaning fluid connector is installed on the third threaded hole;

A fourth threaded hole is formed below the second waste liquid collection chamber, and a waste liquid connector is installed on the fourth threaded hole.

The bottom of the upper body is provided with a first cylindrical shaft, the first cylindrical shaft is integrally formed with the upper body, and the outer side of the first cylindrical shaft is formed with a first sealing groove, which is installed in the first sealing groove with sealing ring;

The upper step hole is arranged on the upper end face of the middle body, the cleaning pool is formed at the center of the bottom of the upper step hole, and the lower step hole is formed at the bottom of the middle body;

The lower body includes a second cylindrical shaft and a second sealing groove, the top of the lower body is provided with the second cylindrical shaft, the second cylindrical shaft is integrally formed on the lower body, and the second cylindrical shaft is The outer side of the casing is formed with the second sealing groove, and a sealing rubber ring is installed in the second sealing groove;

The upper body is inserted into the upper stepped hole through the first cylindrical shaft, and the lower body is inserted into the lower stepped hole through the second cylindrical shaft.

The bottom four corners of the upper body are formed with first screw holes, the top four corners of the middle body are formed with second screw holes, the upper end four corners of the lower body are formed with countersunk holes, and the lower four corners of the lower body are formed with countersunk holes. Fixed U hole;

The upper body and the middle body can be connected by screws through the first screw holes and the second screw holes, and the lower body and the middle body can be connected by screws through the second screw holes and countersunk heads. holes are connected, and the fixing U holes are used for fixing the lower body.

Preferably, a cleaning structure of the present invention for avoiding liquid hanging of a sampling needle is characterized in that: the upper body, the middle body and the lower body are made of alkali-resistant materials, ABS or PP or PEI or PTFE or PEEK.

Preferably, the cleaning structure of the present invention for avoiding liquid hanging on the sampling needle is characterized in that: the number of waste liquid collection holes is 2-8.

Preferably, the cleaning structure of the present invention for avoiding liquid hanging on the sampling needle is characterized in that the included angle between the axes of the two air holes and the axis of the small cavity hole is both 45 degrees.

Preferably, a cleaning structure of the present invention that avoids liquid hanging on the sampling needle is characterized in that: the upper body, the middle body, and the lower body are fastened and connected by screws.

Compared with the prior art, the beneficial effects of the present invention are as follows:

The cleaning structure can effectively avoid liquid hanging after the needle tip is cleaned, has good cleaning effect, high cleaning efficiency, reduces the amount of cleaning liquid, saves time and effort, and has high work efficiency.

Description of drawings

In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the following briefly introduces the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only These are some embodiments of the present invention, and for those of ordinary skill in the art, other drawings can also be obtained from these drawings without any creative effort.

1 is a front cross-sectional view of a cleaning structure for avoiding liquid hanging on a sampling needle according to the present invention;

Fig. 2 is a front cross-sectional view of the upper body of the cleaning structure for avoiding liquid hanging on the sampling needle according to the present invention;

3 is a schematic structural diagram of the upper body of the cleaning structure for avoiding liquid hanging on the sampling needle according to the present invention;

4 is a front cross-sectional view of a body in a cleaning structure for avoiding liquid hanging of a sampling needle according to the present invention;

5 is a schematic structural diagram of a body in a cleaning structure for avoiding liquid hanging on a sampling needle according to the present invention;

6 is a front cross-sectional view of the lower body of a cleaning structure for avoiding liquid hanging on the sampling needle according to the present invention;

7 is a schematic structural diagram of a body under a cleaning structure for avoiding liquid hanging on the sampling needle according to the present invention;

Fig. 8 is the first structural schematic diagram of the use state of the cleaning structure for avoiding liquid hanging on the sampling needle according to the present invention;

9 is a second structural schematic diagram of the use state of a cleaning structure for avoiding liquid hanging on the sampling needle according to the present invention;

FIG. 10 is a third structural schematic diagram of the use state of the cleaning structure for avoiding liquid hanging on the sampling needle according to the present invention.

The reference numerals are explained as follows:

1. Upper body; 11. The first threaded hole; 12. Small cavity hole; 13. Air hole; 131. Through hole; 14. Large cavity hole; 141. Dome; 15. The first cylindrical shaft; Slot; 16, the first screw hole; 2, the middle body; 21, the upper step hole; 22, the cleaning pool; 221, the guide slot; 222, the spherical bottom; 23, the second threaded hole; 24, the third threaded hole ; 25, the lower step hole; 26, the waste liquid collection hole; 27, the first waste liquid collection chamber; 28, the second screw hole; 3, the lower body; 31, the second cylindrical shaft; 311, the second sealing groove; 32 , the fourth threaded hole; 33, the second waste liquid collection chamber; 34, the countersunk head hole; 35, the fixed U hole; 4, the system liquid joint; 5, the enhanced cleaning liquid joint; 8. Sealing ring.

Detailed ways

In the description of the present invention, it should be understood that the terms "center", "portrait", "horizontal", "top", "bottom", "front", "rear", "left", "right", " The orientation or positional relationship indicated by vertical, horizontal, top, bottom, inner, outer, etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and The description is simplified rather than indicating or implying that the device or element referred to must have a particular orientation, be constructed and operate in a particular orientation, and therefore should not be construed as limiting the invention. In addition, the terms "first", "second", etc. are used for descriptive purposes only, and should not be construed as indicating or implying relative importance or implying the number of indicated technical features. Thus, a feature defined as "first", "second", etc., may expressly or implicitly include one or more of that feature. In the description of the present invention, unless otherwise specified, "plurality" means two or more.

In the description of the present invention, it should be noted that the terms "installed", "connected" and "connected" should be understood in a broad sense, unless otherwise expressly specified and limited, for example, it may be a fixed connection or a detachable connection Connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood through specific situations.

The present invention will be further described below in conjunction with the accompanying drawings:

As shown in Fig. 1-Fig. 10, a cleaning structure to avoid liquid hanging on the sampling needle includes an upper body 1, a middle body 2, a lower body 3, a system fluid connector 4, and an enhanced cleaning fluid connector 5. The upper body 1 includes a first The threaded hole 11 and the small cavity hole 12, the two sides of the upper body 1 are formed with a first threaded hole 11, the inner side of the upper body 1 is formed with a small cavity hole 12, the two sides of the small cavity hole 12 are on the inner side of the upper body 1 Two air holes 13 are symmetrically formed, and a through hole 131 is provided at the penetration of the two air holes 13 and the small cavity hole 12 , and a large cavity hole 14 is formed under the small cavity hole 12 and inside the upper body 1 , and the air hole 13 penetrates through the large cavity 13 . The cavity 14, the top of the large cavity 14 is formed with a dome 141, the bottom of the upper body 1 is provided with a first cylindrical shaft 15, the first cylindrical shaft 15 is integrally formed with the upper body 1, and the outer side of the first cylindrical shaft 15 is formed with a The first sealing groove 151, the bottom four corners of the upper body 1 are formed with first screw holes 16, the sealing ring 8 is installed in the first sealing groove 151, the air flow joint 6 is installed on the two first threaded holes 11, and the upper body 1 The middle body 2 is installed below;

The middle body 2 includes an upper step hole 21 and a cleaning pool 22, the upper step hole 21 is arranged on the upper end face of the middle body 2, a cleaning pool 22 is formed at the bottom center of the upper step hole 21, and a second thread is formed on the side of the middle body 2. Hole 23, the upper edge of the cleaning pool 22 is symmetrically formed with two diversion slots 221, the bottom of the cleaning pool 22 is formed with a spherical bottom 222, the second threaded hole 23 runs through the cleaning pool 22, and the other side of the middle body 2 is formed with The third threaded hole 24 , the third threaded hole 24 penetrates the cleaning tank 22 , the bottom of the middle body 2 is formed with a lower step hole 25 , and a first waste liquid collection cavity 27 is formed above the lower step hole 25 and inside the middle body 2 , the outside of the cleaning tank 22 is provided with a waste liquid collection hole 26, the waste liquid collection hole 26 is connected to the first waste liquid collection cavity 27, the top four corners of the middle body 2 are formed with second screw holes 28, and the second threaded holes 23 are installed with The system fluid connector 4, the reinforced cleaning fluid connector 5 is installed on the third threaded hole 24, and the lower body 3 is installed under the middle body 2;

The lower body 3 includes a second cylindrical shaft 31 and a second sealing groove 311. The top end of the lower body 3 is provided with a second cylindrical shaft 31. The second cylindrical shaft 31 is integrally formed on the lower body 3, and the outer side of the second cylindrical shaft 31 is formed with a The second sealing groove 311, a sealing rubber ring is installed in the second sealing groove 311, the inner side of the lower body 3 is formed with a second waste liquid collection cavity 33, the second waste liquid collection cavity 33 penetrates the second cylindrical shaft 31, the second waste liquid collection cavity 33 A fourth threaded hole 32 is formed below the liquid collection chamber 33 , a countersunk hole 34 is formed at four corners of the upper end of the lower body 3 , a fixed U hole 35 is formed at the lower four corners of the lower body 3 , and the fourth threaded hole 32 is installed with waste liquid Connector 7.

Preferably: the upper body 1, the middle body 2 and the lower body 3 are made of alkali-resistant materials, ABS or PP or PEI or PTFE or PEEK; the number of waste liquid collection holes 26 is 2-8; The included angles between the axes of the cavity holes 12 are all 45 degrees; the upper body 1 , the middle body 2 and the lower body 3 are fastened and connected by screws.

The working principle and use method of the present invention: after the needle is filled with the sample, the needle tip is aligned with the small cavity hole 12 and lowered to the designated height in the cleaning pool 22, the needle is opened for cleaning, and the inner wall of the needle is cleaned with the system cleaning solution. The liquid is injected into the cleaning tank 22, and after the cleaning liquid fills the cleaning tank 22, it flows into the waste liquid collection hole 26 through the diversion slot 221;

After the inner cleaning for a certain period of time, the inner cleaning is turned off, and the intensive cleaning is turned on. The intensive cleaning liquid is injected into the cleaning pool 22 through the intensive cleaning liquid joint 5. When the intensive cleaning liquid is injected, the water flow hits the spherical bottom 222 at the bottom of the cleaning pool 22, which acts as an upward surge. After filling the cleaning tank 22 with the enhanced cleaning liquid, it flows into the waste liquid collection hole 26 through the diversion notch 221, and when the enhanced cleaning liquid flows out of the waste liquid tank, the residual sample or reagent spit out from the first needle is washed once the role of;

At the same time of strengthening cleaning, turn on the syringe pump, inhale the strengthening cleaning solution into the needle, and then spit out the strengthening cleaning solution after an interval of 0.5-1s. The function of soaking is to destroy the residual protein on the inner wall of the needle to facilitate cleaning. Adjust the soaking time as needed. The number of soaking can also be increased;

After the intensive cleaning for a period of time, turn off the intensive cleaning, then turn on the inner cleaning of the needle again, the system fluid is spit out from the needle, and the inner wall of the needle is cleaned again. Perform external cleaning. This step of cleaning not only cleans the needle tip, but also removes the residue of the enhanced cleaning solution. The enhanced cleaning solution is a strong alkali. If it is not cleaned, it is easy to damage the protein in the sample or reagent, which will affect the next experimental results, or even destroy it. patient samples;

After using the system fluid for both internal and external cleaning, turn off the ordinary external cleaning, the needle internal cleaning is still carried out, open the air valve, let the high-pressure gas pass through the air flow joint 6, and blow into the small cavity hole 12 under the action of the air hole 13. At this time, the needle is lifted, Raised to a certain height, at this position, the needle tip should be separated from the liquid level of the system fluid in the cleaning tank 22, and lower than the air hole 13, at this time, close the needle for cleaning;

After closing the inner cleaning, the needle continues to be lifted at a slow speed. During the needle lifting process, the airflow is blown to the needle, which has a drying effect on the needle, so as to avoid liquid hanging on the needle tip until the needle is lifted to the designated position higher than the through hole 131 at the bottom of the air hole 13. , the needle returns to the home position at a relatively fast speed, then close the air valve and stop blowing air. From the designated position to the home position, the air blowing has a drying effect on the residual system liquid on the inner wall of the small cavity hole 12.

The foregoing has shown and described the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above-mentioned embodiments, and the descriptions in the above-mentioned embodiments and the description are only to illustrate the principle of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have Various changes and modifications fall within the scope of the claimed invention.

Claims

A cleaning structure for avoiding liquid hanging on a sampling needle, characterized in that it comprises an upper body (1), a middle body (2), a lower body (3), a system fluid connector (4), an enhanced cleaning fluid connector (5), an air flow joint (6), waste liquid joint (7);

Small cavity holes (12) are formed on the inner side of the upper body (1), and air holes (13) are formed on both sides of the small cavity hole (12) and on the inner side of the upper body (1). (13) communicates with the small cavity hole (12), a large cavity hole (14) is formed under the small cavity hole (12) and inside the upper body (1), and the large cavity hole ( 14) The top end is formed with a dome (141), and the air hole (13) is connected with an air flow joint (6);

The middle body (2) is installed below the upper body (1), the middle body (2) includes a cleaning pool (22), and the cleaning pool (22) communicates with the large cavity (14) , the bottom of the cleaning tank (22) is formed with a spherical bottom (222), and a first waste liquid collection cavity (27) is formed inside the middle body (2), and the cleaning tank (22) and the A diversion notch (221) is formed on the adjacent upper edge of the first waste liquid collection cavity (27), and a waste liquid collection hole (26) is provided on the outer side of the cleaning tank (22), and the waste liquid collection hole ( 26) communicating with the first waste liquid collection chamber (27), and the system liquid joint (4) and the enhanced cleaning liquid joint (5) are installed on the middle body (2);

The lower body (3) is installed below the middle body (2), a second waste liquid collecting cavity (33) is formed on the inner side of the lower body (3), and the lower body (3) is connected with a waste liquid collecting cavity (33). Fluid connection (7).
A cleaning structure for avoiding liquid hanging on the sampling needle according to claim 1, characterized in that:

First threaded holes (11) are formed on both sides of the upper body (1), and the air flow joint (6) is connected through the first threaded holes (11);

The side surface of the middle body (2) is formed with a second threaded hole (23), the second threaded hole (23) penetrates the cleaning pool (22), and the other side surface of the middle body (2) is formed with a second threaded hole (23). A third threaded hole (24), the third threaded hole (24) penetrates the cleaning tank (22), the second threaded hole (23) is provided with the system fluid connector (4), the The enhanced cleaning fluid joint (5) is installed on the three threaded holes (24);

A fourth threaded hole (32) is formed under the second waste liquid collection chamber (33), and a waste liquid joint (7) is installed on the fourth threaded hole (32).
A cleaning structure for avoiding liquid hanging on the sampling needle according to claim 1, characterized in that:

The bottom of the upper body (1) is provided with a first cylindrical shaft (15), the first cylindrical shaft (15) is integrally formed with the upper body (1), and the outer side of the first cylindrical shaft (15) A first sealing groove (151) is formed, and a sealing ring (8) is installed in the first sealing groove (151);

The upper step hole (21) is arranged on the upper end face of the middle body (2), the cleaning pool (22) is formed at the center of the bottom of the upper step hole (21), and the bottom of the middle body (2) is formed with the cleaning pool (22). A lower step hole (25) is formed;

The lower body (3) includes a second cylindrical shaft (31) and a second sealing groove (311), the top end of the lower body (3) is provided with the second cylindrical shaft (31), and the second cylindrical shaft (31) The shaft (31) is integrally formed on the lower body (3), the second sealing groove (311) is formed on the outer side of the second cylindrical shaft (31), and a second sealing groove (311) is installed in the second sealing groove (311). sealing ring;

The upper body (1) is inserted into the upper stepped hole (21) through the first cylindrical shaft (15), and the lower body (3) is connected to the lower stepped hole (21) through the second cylindrical shaft (31). The stepped hole (25) is inserted.
A cleaning structure for avoiding liquid hanging on the sampling needle according to claim 3, characterized in that:

The four corners of the bottom of the upper body (1) are formed with first screw holes (16), the four corners of the top of the middle body (2) are formed with second screw holes (28), and the four corners of the upper end of the lower body (3) A countersunk hole (34) is formed, and a fixed U hole (35) is formed at the lower four corners of the lower body (3);

The upper body (1) and the middle body (2) can be connected by screws passing through the first screw holes (16) and the second screw holes (28), and the lower body (3) and the middle body (2) can be connected by screws. The body (2) can be connected through the second screw hole (28) and the countersunk hole (34) by screws, and the fixing U hole (35) is used for fixing the lower body (3).
A cleaning structure for avoiding liquid hanging on a sampling needle according to claim 1, characterized in that: the upper body (1), the middle body (2), and the lower body (3) are made of alkali-resistant materials Material, ABS or PP or PEI or PTFE or PEEK.
The cleaning structure for avoiding liquid hanging on the sampling needle according to claim 1, wherein the number of the waste liquid collection holes (26) is 2-8.
A cleaning structure for avoiding liquid hanging on the sampling needle according to claim 1, characterized in that the included angle between the axes of the two air holes (13) and the axis of the small cavity hole (12) is both 45 degree.
A cleaning structure for avoiding liquid hanging of a sampling needle according to claim 1, characterized in that: the upper body (1), the middle body (2), and the lower body (3) are fastened and connected by screws .