WO2022097064A1 - Inhalateur médical pouvant être activé au moyen de la respiration - Google Patents

Inhalateur médical pouvant être activé au moyen de la respiration Download PDF

Info

Publication number
WO2022097064A1
WO2022097064A1 PCT/IB2021/060224 IB2021060224W WO2022097064A1 WO 2022097064 A1 WO2022097064 A1 WO 2022097064A1 IB 2021060224 W IB2021060224 W IB 2021060224W WO 2022097064 A1 WO2022097064 A1 WO 2022097064A1
Authority
WO
WIPO (PCT)
Prior art keywords
inhaler
housing
manual
low
medical
Prior art date
Application number
PCT/IB2021/060224
Other languages
English (en)
Inventor
Alessandro GUGLIETTA
Original Assignee
Guglietta Alessandro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guglietta Alessandro filed Critical Guglietta Alessandro
Publication of WO2022097064A1 publication Critical patent/WO2022097064A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Definitions

  • the present invention relates to a breath-activated medical inhaler that can be used with manually-activated metered-dose spray inhaler devices.
  • the invention moreover regards a system and a kit for converting a manually-activated inhaler into a breath-activated inhaler device.
  • Drug inhalers are very common for the treatment of obstructive/restrictive pathological conditions of the airways, such as for instance chronic obstructive pulmonary disease (COPD), asthma, or cystic fibrosis.
  • COPD chronic obstructive pulmonary disease
  • asthma asthma
  • cystic fibrosis cystic fibrosis
  • metered-dose spray inhalers or pMDIs (pressurized Metered- Dose Inhalers), drypowder inhalers (DPIs), and nebulizers.
  • pMDIs have become an industrial standard for the treatment of the most widespread respiratory diseases.
  • Manually-activated metered-dose aerosol inhalers comprising a spray canister and a mouthpiece holder.
  • the spray canister comprises a pressure canister of small dimensions, for example made of aluminium or glass, designed to contain a propellant fluid or gas and the medical formulation to be sprayed, a metering valve connected to the pressure canister, as well as a spray nozzle with a pressure actuator arranged on the outside of the canister and connected to the metering valve via a tubular stem.
  • the mouthpiece holder forms a seat for the canister that houses partially the spray canister with the pressure actuator leaning, on the inside, against a bottom wall of the mouthpiece holder and with the spray nozzle facing a mouthpiece opening of the mouthpiece holder that is to be surrounded by the mouth of the user.
  • An upper portion (or bottom) of the pressure canister, extending out of the mouthpiece holder on a side opposite to the bottom wall of the mouthpiece holder, and the bottom wall can be manually pressed towards one another to operate the pressure actuator and deliver the aerosol spray into the oral cavity of the user.
  • This operating mechanism requires a high degree of co-ordination between the user’s hand and the breathing action so that the mist of aerosolized drug will be emitted at the exact moment when the user starts inhaling, and will then reach the inside of the entire bronchial tree to achieve the therapeutic aim.
  • the patient dispenses the drug with a delay or in advance with respect to the start of the inhalation action, the dose administered in depth to the bronchi and to the lungs is reduced, and hence the therapeutic effectiveness. It is therefore of fundamental importance that these known devices are used with an active and co-ordinated participation of the patient.
  • BAIs breath-activated inhalers
  • Known devices such as Autohaler® (3M Company) or Easi-Breathe® (Teva Pharmaceutical Industries) or K-Haler® (Mundipharma) comprise levers or mechanical flaps for detecting the presence of an intensity of inhalation flow higher than a pre-set threshold value for activation of a delivery mechanism.
  • dispensers with a safety blocking device necessarily entail a manual release operation prior to delivery.
  • the object of the present invention is consequently to provide a medical inhaler that can be activated via breathing by the user, having characteristics such that at least some of the drawbacks of the prior art can be overcome.
  • Particular objects of the invention are to provide a breath-activated medical inhaler, having characteristics such as to:
  • Figure 1 is a perspective view of a medical inhaler according to an embodiment of the invention.
  • Figure 2 is a perspective view of the inhaler of Figure 1 , with a part of the housing removed, where a manual pressurized metered-dose inhaler (pMDI) is housed in a removable way in the device;
  • pMDI manual pressurized metered-dose inhaler
  • Figure 3 is a further perspective view of the inhaler of Figure 1 ;
  • Figure 4 is a longitudinal cross-sectional view of the medical inhaler of Figure 1 , loaded with a manual pressurized metered-dose inhaler (pMDI);
  • pMDI manual pressurized metered-dose inhaler
  • Figures 5, 6, and 7 are perspective views of the inhaler of Figure 2, where an external housing is completely removed to render visible the internal components;
  • Figures 8, 9, and 10 are perspective views of a system for operating the inhaler according to one embodiment
  • Figures 11 , 12, and 13 are a perspective view, a lateral view, and a top plan view, respectively, of a spacer element for dimensional adaptation of the inhaler to a type of manual inhaler;
  • Figures 14, 15, and 16 are a perspective view, a lateral view, and a bottom plan view, respectively, of a spacer element for dimensional adaptation of the inhaler to a further type of manual inhaler;
  • Figure 17 shows a known manual pressurized metered-dose inhaler (pMDI).
  • a medical inhaler 1 activatable via breathing by the user, comprises:
  • a housing 2 which can be opened and closed and forms a mouthpiece portion 3 delimiting an outlet opening 4;
  • a dispenser seat 5 formed within the housing 2 to receive a pressure-activatable manual inhaler 6;
  • an electromechanical actuation system 8 arranged within the housing 2 and having a thrust member 11 extending in the dispenser seat 5 to be able to compress or activate by thrust the pressure-activatable manual inhaler 6;
  • a low-pressure detector 10 connected to/in the housing 2 and connected to the electrical control circuit 9, which activates the electromechanical actuation system 8 in response to detection of low pressure by the low-pressure detector 10;
  • the inhalation chamber 7 as a closed chamber, even very weak inhalation actions can generate a low pressure that can be detected by the low-pressure detector 10, allowing use of the inhaler 1 even by persons with low respiratory strength.
  • the low-pressure detector 10 comprises an elastic membrane 10’ integrated in a wall of the housing 2 and elastically deformable in response to a difference in pressure between the environment external to the housing 2 and the inhalation chamber 7 inside it.
  • the elastic membrane 10’ acts upon a switch or microswitch of the electrical control circuit 9, thus causing activation of the electromechanical actuation system 8.
  • the low-pressure detector 10 may comprise a sliding piston 10”, which is elastically withheld in a neutral position in a piston seat formed in a wall of the housing 2 and can be displaced with respect to the neutral position in response to a difference in pressure between the environment external to the housing 2 and the inhalation chamber 7 inside it.
  • the sliding piston 10 acts on a switch or microswitch of the electrical control circuit 9, thus causing activation of the electromechanical actuation system 8.
  • the low-pressure detector 10 may comprise a piezoelectric detector 10”’ deformable in response to a difference in pressure between the environment external to the housing 2 and the inhalation chamber 7 inside it.
  • the piezoelectric detector 10”’ as it undergoes deformation, generates and transmits to the electrical control circuit 9 an electrical signal, thus causing activation of the electromechanical actuation system 8.
  • the compliance (and hence the detection sensitivity) of the low-pressure detector 10 can be selected and set (for example, during manufacture of the inhaler 1) for different breathing intensities.
  • the compliance (and hence the detection sensitivity) of the low-pressure detector 10 can be adjusted via a detector adjustment system 12, for example via a membrane-tensioning mechanism or via a mechanism of elastic pre-loading of the sliding piston or of the piezoelectric sensor.
  • the medical inhaler 1 comprises a manually-activated pushbutton 13 emerging on the outside of the housing 2 and in operative connection with the electromechanical actuation system 8, so that it is possible to operate the manual inhaler 6 housed in the dispenser seat 5, when the manually-activated pushbutton 13 is manually pressed.
  • the manually-activated pushbutton 13 is located on a top wall 14 of the housing 2, opposite to a bottom wall 15 thereof in the vicinity of which, or in a position corresponding to which, the mouthpiece portion 3 extends.
  • the manually-activated pushbutton 13 is located in a position corresponding to the low-pressure detector 10, in particular the elastic membrane 10’, for example in such a way as to cover and protect the low-pressure detector 10 from outside, and possibly mechanically coupled to the low-pressure detector 10.
  • connection rod 16 Mechanical coupling between the manually-activated pushbutton 13 and the low-pressure detector 10, for example the elastic membrane 10’, can be obtained by means of a connection rod 16.
  • the low-pressure detector 10 carries out a movement similar to the one resulting from a low pressure in the inhalation chamber 7 and, consequently, the electrical control circuit 9 controls the electromechanical actuation system 8 to operate the pressure-activatable manual inhaler 6.
  • the user or another person can use the manually-activated pushbutton 13 in the event of emergency to deliver the medical spray even in the absence of a minimal inhalation flow (for example, in the event of a serious asthma attack).
  • the patient’s mouth does not close in a completely hermetic way around the mouthpiece portion 3 and a partial inhalation flow may be created, additional to that through the outlet opening 4.
  • a partial inhalation flow may be created, additional to that through the outlet opening 4.
  • the patient feels the spray of the medicament entering his mouth, he instinctively detaches his lips at least slightly from the mouthpiece portion 3. This would make it possible for the user to breathe in completely and deeply even with the inhalation chamber 7 closed.
  • the medical inhaler 1 may comprise an auxiliary opening system 17, which is operatively connected to at least one of the electromechanical actuation system 8, the electrical control circuit 9, and the low-pressure detector 10, and is configured for opening at least one auxiliary inlet opening 18 in the housing 2 in response to detection of the inhalation action.
  • the auxiliary inlet opening 18 is in communication with the inhalation chamber 7 and temporarily allows a flow of air that passes from outside the housing 2, through the auxiliary inlet opening 18 into the inhalation chamber 7, where it laps a dispensing area 19 of the manual inhaler 6 housed in the dispenser seat 5, and through the outlet opening 4 into the oral cavity of the patient.
  • the auxiliary inlet opening 18 is formed in a rear wall 20 of the housing 2, opposite to a front wall 21 from which the mouthpiece portion 3 extends.
  • the one or more auxiliary inlet openings 18 comprise an inlet window, which is formed in an outer wall of the housing 2 and can be opened/closed via a plate-like or butterfly-like open/close member connected to a thrust mechanism 22 of the electromechanical actuation system 8.
  • the housing 2 forms one or more dose-counter windows 23, which are transparent or made of transparent material, in a wall (preferably a front wall 21 ) of the housing 2 that delimits the dispenser seat 5, wherein the manual inhaler 6 can be inserted and blocked in the dispenser seat 5 with a dose-counter display 24 of the manual inhaler 6 directly facing the dose-counter window 23.
  • a plurality of transparent dose-counter windows 23 may be provided in different positions corresponding to the positioning of the dose-counter display 24 of different types or sizes of manual inhaler 6.
  • the dispenser seat 5 comprises a first end portion 25 (or bottom end portion) that is designed to receive the dispensing area 19 of the manual inhaler 6 and a second end portion 26 (or top end portion) that is opposite to the first end portion 25 and is designed to receive a bottom 27 of the manual inhaler 6.
  • the medical inhaler 1 comprises one or more removable spacers 28, 28’, which have external dimensions corresponding to the internal dimensions of the second end portion 26 of the dispenser seat 5 and internal dimensions corresponding to the external dimensions of the bottom 27 of the manual inhaler 6.
  • the selected spacer 28, 28’ is arranged between the second end portion 26 of the dispenser seat 5 and the bottom 27 of the manual inhaler 6.
  • the removable spacer 28, 28’ comprises at least one U-shaped side wall 29 for adaptation of the dispenser seat 5 to the diametral dimension of the manual inhaler 6 and, optionally, a bottom wall 30, the thickness of which adapts the dispenser seat 5 to the length of the manual inhaler 6.
  • the spacer 28, 28’ may be made of transparent plastic material and form the dose-counter window 23 or be inserted with shape fit in the dose-counter window 23 of the housing 2.
  • the housing 2 and the spacer 28, 28’ are preferably made of plastic material, advantageously of transparent material so that the manual inhaler 6 and the label/trademark/indication of the medicament will be visible from outside the housing 2.
  • the elastic membrane 10’ is preferably made of elastomeric material.
  • the mouthpiece portion 3 can be protected via a removable protective cap 31 , which is also preferably made of plastic material.
  • the manually-activated pushbutton 13 may in turn be protected by means of a protective cap 32, which is also made of plastic.
  • the electromechanical actuation system 8 comprises an electric motor 33, for example a 9 V electric motor, that can be supplied by means of a battery 34, for example a 9 V battery that is preferably replaceable and/or rechargeable.
  • the battery 34, the electric motor 33, and the dispenser seat 5 are arranged on top of one another in a column that extends from a top wall 14 to an opposite bottom wall 15 of the housing, preferably on a front side of the inhaler 1 from which the mouthpiece portion 3 extends.
  • the manually-activated pushbutton 13 (if envisaged), the low- pressure detector 10, the battery 34, the electric motor 33, and the dispenser seat 5 are arranged on top of one another in a column that extends from a top wall 14 to an opposite bottom wall 15 of the housing, preferably on a front side of the inhaler 1 from which the mouthpiece portion 3 extends.
  • the electromechanical actuation system 8 further comprises a thrust mechanism 22, for example a gearing with a lifting cam 35, connected between the electric motor 33 and the thrust member 11 .
  • the thrust mechanism 22 is set laterally with respect to the electric motor 33 and with respect to the dispenser seat 5, preferably on a rear side of the inhaler 1 opposite to the mouthpiece portion 3.
  • the thrust member 22 may be configured like a lifter fork bent at an angle, possibly translatable via the cam 35 and guided, at least in part, by the housing 2.
  • the manual inhaler 6 may, for example, be a manually-activated metered-dose inhaler of aerosol spray, comprising a spray canister 6.1 and a mouthpiece holder 6.2.
  • the spray canister 6.1 contains a propellant fluid and the medical formulation to be sprayed and has a metering valve 6.3 and a spray nozzle 6.4 with a pressure actuator 6.5.
  • the mouthpiece holder 6.2 houses in part the spray canister 6.1 with the pressure actuator 6.5 leaning, inside, against the mouthpiece holder 6.2 and with the spray nozzle 6.4 facing a mouthpiece opening 6.6 of the mouthpiece holder 6.2.
  • a top portion of the spray canister 6.1 , extending out of the mouthpiece holder 6.2, and the mouthpiece holder 6.2 can be compressed towards one another to operate the pressure actuator 6.5 and deliver the spray of aerosol out of the mouthpiece opening 6.6.
  • the manual inhaler 6 is inserted in the dispenser seat 5, with the mouthpiece opening 6.6 facing the outlet opening 4 of the automatic inhaler 1 .
  • the automatic inhaler 1 During use of the automatic inhaler 1 , the user breathes in, gripping the mouthpiece portion 3 between his lips. A low pressure is thus generated in the inhalation chamber 7 that bends the elastic membrane 10’ inwards and causes activation of the electromechanical actuation system 8.
  • the thrust member 11 compresses the manual inhaler 6, causing delivery of a dose of nebulized drug. Displacement of the thrust mechanism 22 frees the auxiliary inlet opening 18 allowing passage of a flow of air through the inhalation chamber 7 that carries the nebulized drug into the oral cavity of the user.
  • Resetting (i.e., re-initialization) of the electromechanical actuation system 8, possibly with reclosing of the auxiliary inlet opening 18, may be obtained via completion of a cycle of movement of the electric motor 33 or by way of the elastic action of return of the manual inhaler 6 and/or via a return spring of the thrust mechanism 22, such as to bring the thrust mechanism 22, and hence the automatic inhaler 1 , back into the detection configuration.
  • the housing 2 may comprise two half-shells that can be connected together via snap action or via screw/screws, and/or may comprise one or more detachable lids, or hinged lids, or sliding lids, which can be closed via snap action or via screw/screws to enable replacement of the manual inhaler 6 and/or of the battery 34.
  • control circuit 9 comprises an electronic control unit with communication interface (for example, USB port, micro-USB port, wireless transmitter or transceiver) for data connection with a portable electronic device (for example, a tablet or else a smartphone) in which a software for monitoring a therapy schedule of the user can be uploaded.
  • a portable electronic device for example, a tablet or else a smartphone
  • the automatic inhaler 1 may be suited to just one size of manual inhaler 6, and hence without spacers 28, 28’ in order to minimize the external dimensions of the housing 2.
  • the battery 34 may be electrically connected to (and rechargeable via) a port, for example a USB or micro-USB port, integrated in the housing 2. This port can function also as communication interface of the electrical control circuit 9.
  • the automatic inhaler 1 can be used in a versatile way with numerous commercially available manual inhalers 6 thanks to adjustment of the shape and size of the dispenser seat 5 obtained by means of the spacers 28, 28’.
  • the automatic inhaler 1 preserves the possibility of viewing the dosecounter mechanisms integrated in manual inhalers 6.
  • the automatic inhaler 1 overcomes the risk of any accidental delivery, even in the absence of a purposely provided blocking mechanism, and is in any case immediately ready for use.
  • the automatic inhaler 1 functions even in the presence of very low respiratory intensities, such as in the very elderly or in young children.
  • the automatic inhaler 1 functions irrespective of the specific pharmacological composition and is hence suitable for the treatment of different pathological conditions.
  • the automatic inhaler 1 optimizes intake of the drug and has very low production costs.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nozzles (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Inhalateur médical (1), qui peut être activé par la respiration de l'utilisateur, comprenant un boîtier (2) présentant une partie embout buccal (3) délimitant une ouverture de sortie (4), un siège de distributeur (5) formé à l'intérieur du boîtier (2) pour recevoir un inhalateur manuel pouvant être activé par pression (6), un système d'actionnement électromécanique (8) présentant un élément de poussée (11) s'étendant dans le siège de distributeur (5) pour comprimer, au moyen d'une poussée, l'inhalateur manuel (6), un circuit de commande électrique (9) pour assurer l'alimentation électrique et le fonctionnement du système d'actionnement électromécanique (8), un détecteur de basse pression (10) relié au circuit de commande électrique (9) qui actionne le système d'actionnement électromécanique (8) en réponse à une détection d'une basse pression du détecteur de basse pression (10), et une chambre d'inhalation (7) en communication avec le détecteur de basse pression (10), le siège de distributeur (5) et l'ouverture de sortie (4). Dans une configuration de détection, l'ouverture de sortie (4) constitue l'unique communication de flux de la chambre d'inhalation (7) avec l'extérieur du boîtier (2), de telle sorte qu'une action d'inhalation de l'utilisateur, par le biais de la partie embout buccal (3), génère une basse pression dans la chambre d'inhalation (7).
PCT/IB2021/060224 2020-11-05 2021-11-04 Inhalateur médical pouvant être activé au moyen de la respiration WO2022097064A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102020000026449 2020-11-05
IT102020000026449A IT202000026449A1 (it) 2020-11-05 2020-11-05 Inalatore medicale attivabile tramite il respiro

Publications (1)

Publication Number Publication Date
WO2022097064A1 true WO2022097064A1 (fr) 2022-05-12

Family

ID=74194971

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2021/060224 WO2022097064A1 (fr) 2020-11-05 2021-11-04 Inhalateur médical pouvant être activé au moyen de la respiration

Country Status (2)

Country Link
IT (1) IT202000026449A1 (fr)
WO (1) WO2022097064A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000770A1 (fr) * 1990-07-09 1992-01-23 Minnesota Mining And Manufacturing Company Inhalateur
US5743252A (en) * 1991-03-05 1998-04-28 Aradigm Corporation Method for releasing controlled amount of aerosol medication
US20190022339A1 (en) * 2015-12-21 2019-01-24 3M Innovative Properties Company Auto-reset dose release firing systems, medicinal inhalers comprising same, and methods of using same
US20200086069A1 (en) * 2015-07-20 2020-03-19 Pearl Therapeutics, Inc. Aerosol delivery systems

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994016759A1 (fr) * 1991-03-05 1994-08-04 Miris Medical Corporation Systeme et procedes de liberation automatique de medicament en aerosol

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000770A1 (fr) * 1990-07-09 1992-01-23 Minnesota Mining And Manufacturing Company Inhalateur
US5743252A (en) * 1991-03-05 1998-04-28 Aradigm Corporation Method for releasing controlled amount of aerosol medication
US20200086069A1 (en) * 2015-07-20 2020-03-19 Pearl Therapeutics, Inc. Aerosol delivery systems
US20190022339A1 (en) * 2015-12-21 2019-01-24 3M Innovative Properties Company Auto-reset dose release firing systems, medicinal inhalers comprising same, and methods of using same

Also Published As

Publication number Publication date
IT202000026449A1 (it) 2022-05-05

Similar Documents

Publication Publication Date Title
US11865250B2 (en) Inhalator device and method
JP7508520B2 (ja) 電子インジケータを備えた呼吸治療システム
US6672304B1 (en) Inhalation actuated device for use with metered dose inhalers (MDIs)
US6357442B1 (en) Inhalation actuated device for use with metered dose inhalers (MDIS)
US20060254581A1 (en) Dose counting in metered dose inhaler
CN113382762B (zh) 与吸入同步的流体产品分配装置及组装装置的方法
US20080173301A1 (en) Variable dose aerosol drug canister
AU2005227849A1 (en) Inhalation actuated device for use with metered dose inhalers (MDIs)
JP7427681B2 (ja) 吸気同期式の流体製品吐出装置
EP3272380B1 (fr) Nébuliseur portatif
CN113382760B (zh) 与吸入同步分配流体产品的流体产品分配装置
AU777964C (en) Inhalation actuated device for use with metered dose inhalers (MDIs)
WO2022097064A1 (fr) Inhalateur médical pouvant être activé au moyen de la respiration

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21816151

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21816151

Country of ref document: EP

Kind code of ref document: A1