WO2022079626A1 - Composition antimicrobienne, en particulier bactéricide, virucide, fongicide et mycobactérienne pour le nettoyage de surfaces contaminées et son utilisation - Google Patents

Composition antimicrobienne, en particulier bactéricide, virucide, fongicide et mycobactérienne pour le nettoyage de surfaces contaminées et son utilisation Download PDF

Info

Publication number
WO2022079626A1
WO2022079626A1 PCT/IB2021/059393 IB2021059393W WO2022079626A1 WO 2022079626 A1 WO2022079626 A1 WO 2022079626A1 IB 2021059393 W IB2021059393 W IB 2021059393W WO 2022079626 A1 WO2022079626 A1 WO 2022079626A1
Authority
WO
WIPO (PCT)
Prior art keywords
copper
composition
based compounds
antimicrobial composition
composition according
Prior art date
Application number
PCT/IB2021/059393
Other languages
English (en)
Inventor
Michele Manica
Original Assignee
MANICA S.p.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MANICA S.p.A. filed Critical MANICA S.p.A.
Priority to EP21802420.6A priority Critical patent/EP4228407A1/fr
Publication of WO2022079626A1 publication Critical patent/WO2022079626A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/046—Salts

Definitions

  • the present invention relates to an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces and to the use of the same.
  • the surfaces of objects and articles ranging from floors, ceilings, door panels, glass windows to, e.g., medical devices, systems, machinery, kitchen worktops, kitchen equipment, can all be contaminated or colonized by microorganisms such as viruses, bacteria, mold, fungi, and in fact, if left dirty, are almost always contaminated with microbes to some degree.
  • Known antimicrobial compositions such as, e.g., commercially available disinfectants, soaps, detergents and sanitizing agents used to fight against contamination of solutions and surfaces with pathogens such as viruses or bacteria are only partly effective in reducing or preventing contamination of any nature, whether viral, microbial, fungal or mycobacterial.
  • DBPs Disinfection Byproducts
  • QACs quaternary ammonium compounds
  • QACs are highly toxic to numerous aquatic organisms, comprising fish, daphnids, algae, rotifers, and other utilized microorganisms, as well as to the environment and humans.
  • Improved or new antimicrobial compositions and disinfectants, soaps, detergents and sanitizing agents are more efficient, more effective and/or safer when considering the duration of prevention against contamination and/or when considering the degree of decontamination and/or when considering the risk to human health or to the environment.
  • a first object of the invention is to provide an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces and its use, with an improved antimicrobial activity against microbes such as viruses, bacteria, fungi and mycobacteria, without posing an unacceptable risk to the environment or human health.
  • a second object of the invention is to provide an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces, which has improved as far as killing microbes, preferably viruses, bacteria, fungi and mycobacteria is concerned, and/or the prevention of the microbial growth on a surface, which, in contrast to known state-of-the-art antimicrobial compositions, does not contain compounds which may cause adverse consequences for the environment and human health, and which is sufficiently effective at eliminating contamination.
  • Another object of the present invention is to devise an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces and its use which allows the mentioned drawbacks of the prior art to be overcome within a simple, rational, easy and effective to use as well as affordable solution.
  • Figures 1-3 are representative graphs of bactericidal efficacy tests and of the duration of the bactericidal action over time.
  • the present invention relates to an antimicrobial composition, particularly bactericidal, virucidal, fungicidal and mycobacterial for the cleaning of contaminated surfaces.
  • antimicrobial activity has its normal scientific meaning throughout the text, and here relates to the activity that kills or blocks the growth of microorganisms.
  • carrier as used herein has its normal scientific meaning throughout the text and here relates to anything in which or on which contaminants, such as microorganisms, i.e. microbes such as bacteria, may be present and/or grow.
  • such a carrier is an aqueous solution, a gas such as air, an object, or a surface such as the surface of an object, such as, e.g., the surface of a ceiling, wall, floor, table, kitchen worktop, machinery, etc.
  • surface has its normal scientific meaning throughout the text, and here relates to any part of an object that constitutes its outer layer, comprising the flat surfaces such as e.g. floors, ceilings, door panels, glass panes, etc., but also other objects such as, e.g., medical devices, systems, machinery, kitchen equipment, etc.
  • contamination as used herein relates to the undesirable presence of pathogens inside or on an object, in an aqueous solution or in a gas such as air.
  • infectious agent has its normal scientific meaning throughout the text, and herein relates to a biocidal antimicrobial agent or an antimicrobial or biocidal solution which is, e.g., applied to the surface of inanimate objects or to a gas such as air, or, in order to destroy living microorganisms on such objects or to prevent contamination of such objects by microbes such as bacteria, viruses, fungi and mycobacteria.
  • the composition comprises: one or more copper-based compounds; one or more surfactants; and an aqueous solution.
  • one or more copper-based compounds indicates that the composition may comprise a plurality of copper-based compounds, either belonging to the same chemical type or belonging to different chemical types.
  • one or more surfactants indicates that the composition may comprise a plurality of surfactants, either belonging to the same chemical type or belonging to different chemical types.
  • the one or more copper-based compounds are present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 0.0001% and 50%.
  • the one or more copper-based compounds are present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 5% and 20%.
  • the one or more copper-based compounds are present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 10% and 15%.
  • each of the one or more copper-based compounds comprise a concentration by weight of copper metal, estimated with respect to the total weight of the one or more copper-based compounds, comprised between 0.0001% and 50%.
  • the one or more copper-based compounds comprise copper sulfate.
  • the one or more copper-based compounds comprise pentahydrate copper sulfate.
  • the one or more surfactants are present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 1% and 40%.
  • composition according to the present invention comprises at least one surfactant present in a concentration by weight comprised between 10% and 20%.
  • the latter comprises a mixture of surfactants present in an overall concentration by weight comprised between 20% and 35%.
  • the aforementioned surfactants are of the ionic and/or non-ionic type.
  • composition according to the invention comprises hydrochloric acid present in a concentration by weight, estimated with respect to the total weight of the composition, comprised between 0.5% and 15%.
  • composition according to the invention comprises one or more chelating agents of the one or more copper-based compounds.
  • the presence of the aforementioned chelating agents is adapted to allow avoiding the precipitation of the one or more copper-based compounds inside the antimicrobial composition and, at the same time, to allow the maintenance thereof in solution.
  • the present invention relates to a disinfectant product, comprising: a) the antimicrobial composition as described above; and b) a thinner, preferably water.
  • the disinfectant product comprises the antimicrobial composition in a concentration by weight, estimated with respect to the total weight of the product, comprised between 0.01% and 5%.
  • the antimicrobial composition according to the present invention has a concentration comprised between 10 mL/L of water and 17 mL/L of water, preferably 15 mL/L of water.
  • the disinfectant product has a pH comprised between 0 and 14.
  • the disinfectant product has a pH comprised between 3 and 6.
  • the aforementioned acid pH allows, in combination with the chelating agents, chelating only a minimum percentage of copper ions, thus ensuring that the latter remain active and persistent on the treated surfaces.
  • the disinfectant product comprises at least one of: one or more antifoaming agents or one or more pH adjusting agents.
  • the present invention relates to the use of the antimicrobial composition in the decontamination of a surface contaminated by a microbe such as a bacterium, virus, or fungus, or a mycobacterium in which the antimicrobial composition is added to the aqueous solution at a concentration of at least 0.01% by weight of the antimicrobial composition based on the total weight of the aqueous solution.
  • a microbe such as a bacterium, virus, or fungus
  • mycobacterium in which the antimicrobial composition is added to the aqueous solution at a concentration of at least 0.01% by weight of the antimicrobial composition based on the total weight of the aqueous solution.
  • the aforementioned protocol was set up by employing the disinfectant product (PRODUCT) with three different concentrations of the antimicrobial composition (COMPOSITION) according to the present invention.
  • the antimicrobial composition employed in the aforementioned experimental protocol comprises: pentahydrate copper sulfate present in a concentration by weight substantially equal to 13.5%; surfactants present in an overall concentration by weight substantially equal to 33.6%; hydrochloric acid present in a concentration by weight substantially equal to 8.9%; water present in a concentration by weight substantially equal to 43.2%.
  • the disinfectant product thus prepared was sprayed as follows: a surface (worktop) made of monolithic stoneware has been artificially contaminated by spraying with waste water (the same water and the same level of spraying will be used);
  • the copper ions released in water, by means of ionic bonds form the protective film having considerable effectiveness and duration over time compared to the currently known antimicrobial compositions and disinfectant products.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne une composition antimicrobienne, en particulier bactéricide, virucide, fongicide et mycobactérienne pour le nettoyage de surfaces contaminées, comprenant : un ou plusieurs composés à base de cuivre ; un ou plusieurs tensioactifs ; et une solution aqueuse.
PCT/IB2021/059393 2020-10-14 2021-10-13 Composition antimicrobienne, en particulier bactéricide, virucide, fongicide et mycobactérienne pour le nettoyage de surfaces contaminées et son utilisation WO2022079626A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP21802420.6A EP4228407A1 (fr) 2020-10-14 2021-10-13 Composition antimicrobienne, en particulier bactéricide, virucide, fongicide et mycobactérienne pour le nettoyage de surfaces contaminées et son utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102020000024271A IT202000024271A1 (it) 2020-10-14 2020-10-14 Composizione antimicrobica, particolarmente battericida, virucida, fungicida e micobatterica per la detersione di superfici contaminate e relativo uso
IT102020000024271 2020-10-14

Publications (1)

Publication Number Publication Date
WO2022079626A1 true WO2022079626A1 (fr) 2022-04-21

Family

ID=74068488

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2021/059393 WO2022079626A1 (fr) 2020-10-14 2021-10-13 Composition antimicrobienne, en particulier bactéricide, virucide, fongicide et mycobactérienne pour le nettoyage de surfaces contaminées et son utilisation

Country Status (3)

Country Link
EP (1) EP4228407A1 (fr)
IT (1) IT202000024271A1 (fr)
WO (1) WO2022079626A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030157188A1 (en) * 2002-02-20 2003-08-21 Global Microbio Products, L.L.C. Bactericide solution and method of making same
US20080015140A1 (en) * 2002-06-28 2008-01-17 Veckis Industries Ltd. Disinfecting composition
US7465697B1 (en) * 2006-11-02 2008-12-16 Ohsoclean, Inc. Essential oils based cleaning and disinfecting compositions
US20180263245A1 (en) * 2015-02-12 2018-09-20 Christian CREMONA Water-based disinfectant
US10440958B1 (en) * 2014-12-05 2019-10-15 Pen Inc. Disinfectant material comprising a copper halide salt and surfactant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030157188A1 (en) * 2002-02-20 2003-08-21 Global Microbio Products, L.L.C. Bactericide solution and method of making same
US20080015140A1 (en) * 2002-06-28 2008-01-17 Veckis Industries Ltd. Disinfecting composition
US7465697B1 (en) * 2006-11-02 2008-12-16 Ohsoclean, Inc. Essential oils based cleaning and disinfecting compositions
US10440958B1 (en) * 2014-12-05 2019-10-15 Pen Inc. Disinfectant material comprising a copper halide salt and surfactant
US20180263245A1 (en) * 2015-02-12 2018-09-20 Christian CREMONA Water-based disinfectant

Also Published As

Publication number Publication date
EP4228407A1 (fr) 2023-08-23
IT202000024271A1 (it) 2022-04-14

Similar Documents

Publication Publication Date Title
Dvorak Disinfection 101
US8940792B2 (en) Antimicrobial composition and methods for using same
Oule et al. Akwaton, polyhexamethylene-guanidine hydrochloride-based sporicidal disinfectant: a novel tool to fight bacterial spores and nosocomial infections
Trueman The halogens
WO2004003121A1 (fr) Composition désinfectante
Ni et al. Application of slightly acidic electrolyzed water for decontamination of stainless steel surfaces in animal transport vehicles
Thorn et al. Comparative antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and electrochemically activated solutions evaluated using a novel standardized assay
Ni et al. Reduction of microbial contamination on the surfaces of layer houses using slightly acidic electrolyzed water
US20200128822A1 (en) Hyperprotonation Compositions And Methods Of Use For Cleaning, Disinfection, And Sterilization
Tango et al. Application of electrolyzed water on environment sterilization
KR100669204B1 (ko) 소독 및 탈취제 조성물 및 이의 제조방법
US11279902B2 (en) Hyperprotonation cleaning, disinfection, and sterilization compositions and methods
WO2020144522A1 (fr) Composition antimicrobienne, procédé de préparation, désinfectant, détergent et assainisseur la contenant et leur utilisation
Ahmed et al. Efficacy of chlorine dioxide gas in reducing Escherichia coli and Salmonella from broiler house environments
WO2022079626A1 (fr) Composition antimicrobienne, en particulier bactéricide, virucide, fongicide et mycobactérienne pour le nettoyage de surfaces contaminées et son utilisation
JP2001181115A (ja) 殺菌組成物及びその使用方法
Konopka et al. Disinfection of meat industry equipment and production rooms with the use of liquids containing silver nano-particles
Alpysbayeva et al. Development of a Disinfectant Composition Based on Hydrogen Peroxide
RU2711293C1 (ru) Дезинфицирующее средство
WO2016128868A1 (fr) Désinfectant à base d'eau
Dvorak et al. Sanitation and disinfection
Bennett The importance of biosecurity in the modern day hatchery
MADUBUCHI ETOPIC APPLICATION OF LIQUID DISINFECTANTS IN THE TREATMENT OF WOUNDS USING ANIMAL MODELS (ALBINO RATS)
Yan et al. New Clinical Applications of Electrolyzed Water: A Review. Microorganisms 2021, 9, 136
RU2224544C1 (ru) Дезинфицирующее средство

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21802420

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2021802420

Country of ref document: EP

Effective date: 20230515