WO2022074157A1 - Substrat de formation d'aérosol - Google Patents
Substrat de formation d'aérosol Download PDFInfo
- Publication number
- WO2022074157A1 WO2022074157A1 PCT/EP2021/077782 EP2021077782W WO2022074157A1 WO 2022074157 A1 WO2022074157 A1 WO 2022074157A1 EP 2021077782 W EP2021077782 W EP 2021077782W WO 2022074157 A1 WO2022074157 A1 WO 2022074157A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aerosol
- percent
- weight
- forming substrate
- content
- Prior art date
Links
- 239000000758 substrate Substances 0.000 title claims abstract description 606
- 229920002678 cellulose Polymers 0.000 claims abstract description 91
- 239000001913 cellulose Substances 0.000 claims abstract description 91
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 91
- 238000005728 strengthening Methods 0.000 claims abstract description 91
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 79
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 79
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 79
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 79
- 239000000443 aerosol Substances 0.000 claims abstract description 78
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 53
- 235000010980 cellulose Nutrition 0.000 claims description 89
- 229920003043 Cellulose fiber Polymers 0.000 claims description 57
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 51
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 51
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 51
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 51
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 50
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 40
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 40
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 40
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 10
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 10
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 10
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 50
- 229960002715 nicotine Drugs 0.000 description 46
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 46
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 39
- 238000010438 heat treatment Methods 0.000 description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 12
- 230000001939 inductive effect Effects 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 229920001817 Agar Polymers 0.000 description 10
- 239000008272 agar Substances 0.000 description 10
- 238000009472 formulation Methods 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 230000001965 increasing effect Effects 0.000 description 8
- 235000019504 cigarettes Nutrition 0.000 description 7
- 239000002002 slurry Substances 0.000 description 7
- 238000012546 transfer Methods 0.000 description 7
- 150000001735 carboxylic acids Chemical class 0.000 description 6
- 229920002301 cellulose acetate Polymers 0.000 description 5
- 230000006698 induction Effects 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 125000006850 spacer group Chemical group 0.000 description 5
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000002788 crimping Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 102100033864 G-protein coupled receptor 84 Human genes 0.000 description 2
- 101001069589 Homo sapiens G-protein coupled receptor 84 Proteins 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000005672 electromagnetic field Effects 0.000 description 2
- 229940040102 levulinic acid Drugs 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 description 1
- SDVKWBNZJFWIMO-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.OC(=O)CC(O)(C(O)=O)CC(O)=O SDVKWBNZJFWIMO-UHFFFAOYSA-N 0.000 description 1
- VWTHFJXLFGINSW-PPHPATTJSA-N 2-hydroxypropanoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound CC(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 VWTHFJXLFGINSW-PPHPATTJSA-N 0.000 description 1
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- VAUQRLHPXWYZRZ-PPHPATTJSA-N benzoic acid 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)c1ccccc1.CN1CCC[C@H]1c1cccnc1 VAUQRLHPXWYZRZ-PPHPATTJSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- LDMPZNTVIGIREC-ZGPNLCEMSA-N nicotine bitartrate Chemical compound O.O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 LDMPZNTVIGIREC-ZGPNLCEMSA-N 0.000 description 1
- 229940069688 nicotine bitartrate Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/36—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring
- A24B15/40—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring having only oxygen or sulfur as hetero atoms
- A24B15/403—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring having only oxygen or sulfur as hetero atoms having only oxygen as hetero atoms
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D1/00—Cigars; Cigarettes
- A24D1/20—Cigarettes specially adapted for simulated smoking devices
Abstract
L'invention concerne un substrat de formation d'aérosol (1020) destiné à être utilisé dans un système de génération d'aérosol (2000). Le substrat de formation d'aérosol (1020) comprend : un ou plusieurs agents de formation d'aérosol ; de l'hydroxypropylméthyl cellulose ; et un ou plusieurs agents de renforcement à base de cellulose. Le substrat de formation d'aérosol (1020) a une teneur en agent de formation d'aérosol supérieure à 30 pour cent en poids. Le ou les agents de renforcement à base de cellulose comprennent de la poudre de cellulose. Le substrat de formation d'aérosol (1020) a une teneur en poudre de cellulose comprise entre environ 0,5 pour cent en poids et environ 50 pour cent en poids.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023520182A JP2023544038A (ja) | 2020-10-07 | 2021-10-07 | エアロゾル形成基体 |
| BR112023006128A BR112023006128A2 (pt) | 2020-10-07 | 2021-10-07 | Substrato formador de aerossol |
| MX2023003823A MX2023003823A (es) | 2020-10-07 | 2021-10-07 | Un sustrato formador de aerosol. |
| US18/247,294 US20230404132A1 (en) | 2020-10-07 | 2021-10-07 | An aerosol-forming substrate |
| IL301819A IL301819A (en) | 2020-10-07 | 2021-10-07 | A spray forming substrate |
| EP21782770.8A EP4225055A1 (fr) | 2020-10-07 | 2021-10-07 | Substrat de formation d'aérosol |
| KR1020237014419A KR20230080444A (ko) | 2020-10-07 | 2021-10-07 | 에어로졸 형성 기재 |
| AU2021357355A AU2021357355A1 (en) | 2020-10-07 | 2021-10-07 | An aerosol-forming substrate |
| CA3195031A CA3195031A1 (fr) | 2020-10-07 | 2021-10-07 | Substrat de formation d'aerosol |
| CN202180067167.8A CN116249457A (zh) | 2020-10-07 | 2021-10-07 | 气溶胶形成基质 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20200643 | 2020-10-07 | ||
| EP20200643.3 | 2020-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2022074157A1 true WO2022074157A1 (fr) | 2022-04-14 |
Family
ID=72801431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2021/077782 WO2022074157A1 (fr) | 2020-10-07 | 2021-10-07 | Substrat de formation d'aérosol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230404132A1 (fr) |
| EP (1) | EP4225055A1 (fr) |
| JP (1) | JP2023544038A (fr) |
| KR (1) | KR20230080444A (fr) |
| CN (1) | CN116249457A (fr) |
| AU (1) | AU2021357355A1 (fr) |
| BR (1) | BR112023006128A2 (fr) |
| CA (1) | CA3195031A1 (fr) |
| IL (1) | IL301819A (fr) |
| MX (1) | MX2023003823A (fr) |
| WO (1) | WO2022074157A1 (fr) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4333484A (en) * | 1978-08-02 | 1982-06-08 | Philip Morris Incorporated | Modified cellulosic smoking material and method for its preparation |
| WO1995027411A1 (fr) | 1994-04-08 | 1995-10-19 | Philip Morris Products Inc. | Systemes de chauffage par induction pour articles pour fumeurs |
| US20040247646A1 (en) * | 2003-03-26 | 2004-12-09 | The Procter & Gamble Company | Rapidly dissolving edible film compositions with improved film strength and stability |
| US20120199149A1 (en) * | 2003-11-07 | 2012-08-09 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| WO2015177255A1 (fr) | 2014-05-21 | 2015-11-26 | Philip Morris Products S.A. | Dispositif de chauffage par induction pour chauffer un substrat de formation d'aérosol |
| US20200281249A1 (en) * | 2019-03-06 | 2020-09-10 | R.J. Reynolds Tobacco Company | Aerosol delivery device with nanocellulose substrate |
| WO2021170670A1 (fr) | 2020-02-28 | 2021-09-02 | Philip Morris Products S.A. | Nouveau substrat de génération d'aérosol |
-
2021
- 2021-10-07 MX MX2023003823A patent/MX2023003823A/es unknown
- 2021-10-07 CN CN202180067167.8A patent/CN116249457A/zh active Pending
- 2021-10-07 US US18/247,294 patent/US20230404132A1/en active Pending
- 2021-10-07 IL IL301819A patent/IL301819A/en unknown
- 2021-10-07 JP JP2023520182A patent/JP2023544038A/ja active Pending
- 2021-10-07 KR KR1020237014419A patent/KR20230080444A/ko unknown
- 2021-10-07 EP EP21782770.8A patent/EP4225055A1/fr active Pending
- 2021-10-07 AU AU2021357355A patent/AU2021357355A1/en active Pending
- 2021-10-07 WO PCT/EP2021/077782 patent/WO2022074157A1/fr unknown
- 2021-10-07 BR BR112023006128A patent/BR112023006128A2/pt unknown
- 2021-10-07 CA CA3195031A patent/CA3195031A1/fr active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4333484A (en) * | 1978-08-02 | 1982-06-08 | Philip Morris Incorporated | Modified cellulosic smoking material and method for its preparation |
| WO1995027411A1 (fr) | 1994-04-08 | 1995-10-19 | Philip Morris Products Inc. | Systemes de chauffage par induction pour articles pour fumeurs |
| US20040247646A1 (en) * | 2003-03-26 | 2004-12-09 | The Procter & Gamble Company | Rapidly dissolving edible film compositions with improved film strength and stability |
| US20120199149A1 (en) * | 2003-11-07 | 2012-08-09 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| WO2015177255A1 (fr) | 2014-05-21 | 2015-11-26 | Philip Morris Products S.A. | Dispositif de chauffage par induction pour chauffer un substrat de formation d'aérosol |
| US20200281249A1 (en) * | 2019-03-06 | 2020-09-10 | R.J. Reynolds Tobacco Company | Aerosol delivery device with nanocellulose substrate |
| WO2021170670A1 (fr) | 2020-02-28 | 2021-09-02 | Philip Morris Products S.A. | Nouveau substrat de génération d'aérosol |
Non-Patent Citations (1)
| Title |
|---|
| S. KAMEL: "Pharmaceutical significance of cellulose: A review", EXPRESS POLYMER LETTERS, vol. 2, no. 11, 1 January 2008 (2008-01-01), pages 758 - 778, XP055224467, DOI: 10.3144/expresspolymlett.2008.90 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112023006128A2 (pt) | 2023-05-09 |
| CA3195031A1 (fr) | 2022-04-14 |
| US20230404132A1 (en) | 2023-12-21 |
| JP2023544038A (ja) | 2023-10-19 |
| MX2023003823A (es) | 2023-04-13 |
| IL301819A (en) | 2023-06-01 |
| KR20230080444A (ko) | 2023-06-07 |
| AU2021357355A1 (en) | 2023-05-04 |
| EP4225055A1 (fr) | 2023-08-16 |
| CN116249457A (zh) | 2023-06-09 |
| AU2021357355A9 (en) | 2024-05-02 |
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