WO2022064608A1

WO2022064608A1 - Hydrous adhesive patch for non-medical product

Info

Publication number: WO2022064608A1
Application number: PCT/JP2020/036081
Authority: WO
Inventors: 眞金箱
Original assignee: ニチバン株式会社
Priority date: 2020-09-24
Filing date: 2020-09-24
Publication date: 2022-03-31
Also published as: JPWO2022064608A1

Abstract

[Problem] To provide a hydrous adhesive patch which retains adhesive force even after the water contained in the pressure-sensitive adhesive layer has volatilized off. [Solution] A hydrous adhesive patch for non-medical products which includes a pressure-sensitive adhesive layer including an emulsion of an alkyl acrylate copolymer in a proportion of 20 mass% or higher but less than 70 mass%, the alkyl acrylate copolymer being a copolymer of a monomer mixture comprising monomer A and monomer B. The monomer A is a monomer which, when homopolymerized, forms a polymer having a glass transition temperature (Tg) of 270K or higher, and the monomer B is a monomer which, when homopolymerized, forms a polymer having a glass transition temperature (Tg) of 220K or lower.

Description

Non-pharmaceutical water-containing patch

The present invention relates to a non-pharmaceutical water-containing patch, and more specifically, a water-containing patch that maintains high adhesive strength even after the water in the pressure-sensitive adhesive layer is volatilized and has low skin irritation. Regarding the agent.

A patch using a water-containing adhesive base, which is also generally referred to as a "pap agent" (referred to as a water-containing adhesive in the present specification), has a plaster layer (adhesive layer) as a woven fabric, knitted fabric, non-woven fabric, or the like. It is a kind of patch to be provided on the support of. Since the poultice uses an adhesive base containing water in the plaster layer, the adhesive strength is weak although the skin irritation is low, and the adhesive strength decreases with time, especially with the volatilization of water in the plaster layer. The problem was that it was easy to peel off from the skin.
In order to solve these problems, an emulsion (also called emulsion) base in which an acrylic acid alkyl ester copolymer known as one component constituting a non-aqueous (hydrophobic or lipophilic) adhesive is dispersed is used. A technique of blending a water-containing patch into a plaster layer (adhesive layer) is known.

For example, Patent Document 1 aims to provide a water-containing patch having excellent adhesive force and re-sticking force even after long-term sticking, and suppressing hardening and suppleness due to loss of water. 5.0% by mass or more and 10% by mass or less of the methyl acrylate / 2-ethylhexyl acrylate copolymer and 0.01% by mass or more of the water-dispersible surfactant with respect to the entire composition for a water-containing external patch. A patch containing 10.0% by mass or less is disclosed.
Further, in Patent Document 2, a polyacrylic acid neutralized product and the neutralized product 2. A poultice containing 5 to 10 times by mass (5 to 25% by mass based on a plaster) of a methyl acrylate / 2-ethylhexyl acrylate copolymer and polyacrylic acid is disclosed.
Patent Document 3 contains poly (methyl acrylate / 2-ethylhexyl acrylate) and a monofatty acid ester of polyethylene glycol as a surfactant for the purpose of providing a poultice that can peel off a peeling liner with a smaller force. Pap agents are disclosed.

Patent No. 5650684 Patent No. 5921779 Patent No. 6469136

As described above, it is known that an acrylic acid alkyl ester copolymer such as a methyl acrylate / 2-ethylhexyl acrylate copolymer is blended in the pressure-sensitive adhesive layer in order to enhance the adhesive durability of the water-containing patch. ing.
However, in the water-containing adhesives proposed so far, the adhesive strength after the moisture in the adhesive layer is volatilized is not sufficiently satisfactory as compared with the tape agent.
In addition, conventionally, hydrophilic acrylic pressure-sensitive adhesives (polyacrylic acid partially neutralized products (manufactured by Showa Denko Corporation, Viscomate (registered trademark) NP-800, etc.), etc.) and stickiness constituting the pressure-sensitive adhesive layer of water-containing patches have been used. Since the thickening agent (sodium carmellose, etc.) is usually a highly hydrophilic high molecular compound, lumps may occur when it is directly put into water. In addition, when it is necessary to suppress the dissolution of a cross-linking agent (dihydroxyaluminum aminoacetate (manufactured by Kyowa Chemical Industry Co., Ltd., glycinal, etc.) so as not to dissolve in water and lose its function). There is. For this reason, a method of dispersing these components in a wetting agent containing almost no water and adding the components to a composition forming a pressure-sensitive adhesive layer is generally practiced in the production of a poultice. However, when the emulsion is blended in a proportion of 20% by mass or more, a water-free wetting agent (concentrated) that plays a role of dispersing the above-mentioned hydrophilic acrylic pressure-sensitive adhesive, thickening agent and cross-linking agent in the pressure-sensitive adhesive layer. The amount of glycerin, etc.) is relatively small. Therefore, these components cannot be sufficiently dispersed in the pressure-sensitive adhesive layer, and as a result, there is a problem that lumps are generated in the pressure-sensitive adhesive.
Further, when an acrylic acid alkyl ester copolymer such as a methyl acrylate / 2-ethylhexyl acrylate copolymer is blended in an amount of 20% or more, the blending amount of other components is reduced, the cross-linking reaction becomes difficult, and the shape is retained. There was a problem that I couldn't keep my sex.

As a result of diligent research to solve the above problems, the present inventors have made a glass transition when homopolymerized as an acrylic acid alkyl ester-based copolymer on the pressure-sensitive adhesive layer of a non-pharmaceutical water-containing patch. A copolymer emulsion obtained by copolymerizing a monomer having a temperature (Tg) of 270 K or more and a polymer having a Tg of 220 K or less when homopolymerized is 20% by mass or more 70, which far exceeds the conventional amount. By blending in a proportion of less than mass%, the generation of lumps during the formation of the pressure-sensitive adhesive layer is suppressed, the crosslinkability and shape retention are not impaired, and the adhesive strength even after the moisture in the pressure-sensitive adhesive layer is volatilized. The present invention has been completed by finding that the polymer does not decrease, but rather improves significantly, and that the skin irritation is also low.

That is, the present invention is:
[1]
A non-pharmaceutical water-containing patch comprising a support, an adhesive layer provided on the support, and a release liner.
The pressure-sensitive adhesive layer
1) Acrylic hydrophilic adhesive,
2) Acrylic acid alkyl ester-based copolymer emulsion,
3) Crosslinking agent,
4) Condensing agent,
5) Wetting agents containing little water, and 6) water,
Contains,
The acrylic acid alkyl ester copolymer is a copolymer of a monomer mixture composed of monomer A and monomer B.
The monomer A is a polymer having a glass transition temperature (Tg) of 270 K or higher when the monomer A is homopolymerized.
The monomer B is a polymer having a glass transition temperature (Tg) of 220 K or less when the monomer B is homopolymerized.
The acrylic acid alkyl ester-based copolymer emulsion is contained in a proportion of 20% by mass or more and less than 70% by mass with respect to the total mass of the pressure-sensitive adhesive layer.
Water-containing patch for non-pharmaceutical products.

Further, according to the present invention, the following embodiments are further provided.
[2]
The non-pharmaceutical water-containing patch according to [1], which comprises one or more of the following (a) to (c).
a) The acrylic acid alkyl ester-based copolymer is an acrylic acid alkyl ester-based copolymer in which the proportion of the monomer A is 30% by mass or more and 50% by mass or less with respect to the total mass of the monomer mixture. ..
b) The pressure-sensitive adhesive layer has a pH of 2 to 4.
c) The mass ratio of the total amount of the hydrophilic acrylic pressure-sensitive adhesive, the thickening agent, and the cross-linking agent to the amount of the wetting agent (moisture 16% or less) containing almost no water is (total). Blending amount) / (the wetting agent) = 7.25 / 25 to 7.25 / 10.
[3]
The wetting agent containing almost no water is concentrated glycerin, glycerin, D-sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, liquid paraffin, 1,3-propanediol, 1,4-butanediol, and martitol. The non-pharmaceutical water-containing patch according to [1] or [2], which is selected from the group consisting of, and xylitol.
[4]
The pressure-sensitive adhesive layer is
It has a peel adhesive strength of 1N / 15 mm or more after storage at 50 ° C. for 16 hours from the date of manufacture of the patch.
Immediately after the patch is manufactured, it has a probe tack of 0.7 N / mmφ or more and has a probe tack.
The probe tack value of the pressure-sensitive adhesive layer immediately after the production of the patch is 1.8 times or more the probe tack value of the pressure-sensitive adhesive layer after storage at 50 ° C. for 16 hours from the date of manufacture of the patch.
The non-pharmaceutical water-containing patch according to any one of [1] to [3].
[5]
The pressure-sensitive adhesive layer is further 7) a cooling agent 8) an organic solvent,
9) pH regulator,
10) Chelating agent,
The non-pharmaceutical water-containing patch according to any one of [1] to [4].

According to the present invention, a monomer mixture consisting of a monomer A having a glass transition temperature (Tg) of 270 K or more at the time of homopolymerization and a monomer B having a Tg of 220 K or less at the time of homopolymerization. By blending the emulsion of the acrylic acid alkyl ester-based copolymer as the polymer in the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch in an amount of 20% by mass or more and less than 70% by mass, and in a preferred embodiment, a. ) Adopt an acrylic acid alkyl ester-based copolymer in which the proportion of the monomer A is 30% by mass or more and 50% by mass or less with respect to the total mass of the monomer mixture, or b) the pressure-sensitive adhesive layer has a pH of 2 to 4. Or c) Total amount of hydrophilic polymer (hydrophilic acrylic pressure-sensitive adhesive and thickening agent) and cross-linking agent / mass of amount of wetting agent containing almost no water (concentrated glycerin, etc.) By setting the ratio to 7.25 / 25 to 7.25 / 10, the generation of lumps during the formation of the pressure-sensitive adhesive layer can be suppressed, and the adhesive strength can be maintained even after the water content in the pressure-sensitive adhesive layer is volatilized. , A non-pharmaceutical water-containing patch having low skin irritation can be provided.

As described above, acrylics such as methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion (trade name: Nicazole TS-620, Nippon Carbide Industries Co., Ltd.), etc., in order to enhance the durability of the adhesive strength of the water-containing patch. Proposals have been made to blend an acid alkyl ester copolymer emulsion into the pressure-sensitive adhesive layer and to increase the blending amount. However, in the proposals so far, even when the blending amount of the copolymer is increased, the adhesive strength after the water in the pressure-sensitive adhesive layer is volatilized (after water volatilization) is sufficiently sufficient as compared with the tape agent. I couldn't say that.
The present inventors have encountered the above-mentioned problems in an amount of 20% by mass or more and less than 70% by mass, which exceeds the amount previously proposed, and is an emulsion of a copolymerized resin emulsion of methyl acrylate and 2-ethylhexyl acrylate (hereinafter, co-weight). By blending (also referred to as a coalesced emulsion) in the pressure-sensitive adhesive layer, it is possible to provide a non-pharmaceutical water-containing patch which can maintain the adhesive strength even after the water in the pressure-sensitive adhesive layer is volatilized and has low skin irritation. I found.
Hereinafter, the configuration of the non-pharmaceutical water-containing patch of the present invention will be described.

The non-pharmaceutical water-containing patch of the present invention (hereinafter, also simply referred to as “patch”) comprises a support, a pressure-sensitive adhesive layer provided on the support, and a release liner.
The shape of the patch, particularly the support, and the preparation portion consisting of the pressure-sensitive adhesive layer provided on the support is not particularly limited, and is rectangular (square, rectangle, etc.), quadrangular (trapezoid, rhombus, etc.), polygonal. , Circular, oval, semi-circular, triangular, crescent-shaped, and a combination of these, etc., various shapes can be selected according to the attachment location.
The area of the patch (particularly the above-mentioned pharmaceutical product portion) can be appropriately determined, and can be, for example, in the range of 2 to 300 cm ² in consideration of the purpose of use of the patch.

[Adhesive layer]
The non-pharmaceutical water-containing patch of the present invention generally constitutes a non-aqueous acrylic pressure-sensitive adhesive in addition to the hydrophilic acrylic pressure-sensitive adhesive described later for the water-containing pressure-sensitive adhesive layer. It is characterized by blending an emulsion of an ester-based copolymer.
Generally, the pressure-sensitive adhesive used for the pressure-sensitive adhesive layer (plaster layer) of a water-containing patch includes polyacrylic acid, partially neutralized polyacrylic acid, sodium polyacrylate, and N-vinylacetamide / sodium acrylate copolymer. Hydrophilic acrylic pressure-sensitive adhesives such as resins are widely used. From the viewpoint of having high affinity with the above-mentioned hydrophilic acrylic pressure-sensitive adhesive and being able to be kneaded uniformly, the non-water-based pressure-sensitive adhesive to be blended in the water-containing pressure-sensitive adhesive layer of the water-containing patch includes acrylic and methacrylic adhesives. An emulsion-type pressure-sensitive adhesive is preferably blended.
In the present specification, the "acrylic acid alkyl ester-based copolymer" is intended to contain both acrylic acid and methacrylic acid alkyl esters, and the "acrylic adhesive" is also an acrylic pressure-sensitive adhesive and methacrylic acid. It is intended to contain both of the adhesives.

<Acrylic acid alkyl ester-based copolymer>
The acrylic acid alkyl ester-based copolymer (non-aqueous pressure-sensitive adhesive base) constituting the non-aqueous acrylic pressure-sensitive adhesive has an alkyl ester having 2 to 9 carbon atoms as a component that exhibits adhesive strength, and is homopolymerized. A monomer having a glass transition temperature (Tg) of −55 ° C. (218K) or less when allowed to grow, and a polymer having a Tg of 8 to 165 ° C. (281 to 438K) when homopolymerized as a component for improving aggregation power. It is a copolymer composed of a monomer having a above-mentioned monomer and a monomer having a functional group such as a cross-linking point such as a carboxyl group or a hydroxy group if necessary (an example of the monomer is given in Table 1).
The acrylic acid alkyl ester-based copolymer used in the present invention has a monomer A which is a polymer having a glass transition temperature (Tg) of 270 K or more when homopolymerized, and a glass transition temperature (Tg) of 220 K or less when homopolymerized. It is a copolymer of a monomer mixture composed of a monomer B as a polymer. The upper limit of the glass transition temperature Tg of the homopolymer of the monomer A is about 500 K, and the lower limit of the glass transition temperature Tg of the homopolymer of the monomer B is about 200 K.

It should be noted that homopolymers obtained by polymerizing only a monomer that exhibits adhesive strength are said to have high adhesive strength but weak mechanical strength, and in general, copolymerization with a monomer that improves cohesive strength improves mechanical strength. The coalescence is used as an adhesive.
As mentioned as the monomer exhibiting the adhesive strength shown in Table 1 above, in the present invention, as a monomer having a higher adhesive strength, acrylic acid having a Tg of 220 K or less when the monomer is homopolymerized (homopolymer). Butyl acrylate, 2-ethylhexyl acrylate, octyl acrylate, isononyl acrylate and the like are used. Of these, butyl acrylate and 2-ethylhexyl acrylate are preferable, and 2-ethylhexyl acrylate, which has a proven track record as a pharmaceutical additive and has high adhesive strength (low homopolymer Tg), can be preferably used. ..
Examples of the monomers that improve the aggregating power (the homopolymer Tg is 270 K or more) include the monomers listed in Table 1. Among these, methyl acrylate, methyl methacrylate, ethyl methacrylate and n-butyl methacrylate are preferable. In the present invention, methyl acrylate, which has high mechanical strength and does not significantly reduce the adhesiveness (the Tg of the homopolymer is relatively low), is particularly preferable.

As mentioned in the prior art, as an emulsion of a commercially available acrylic acid alkyl ester-based copolymer used for a patch, Nikazole (registered trademark) TS-620 (methyl acrylate) manufactured by Nippon Carbide Co., Ltd. -There is a 2-ethylhexyl acrylate copolymer resin emulsion). The methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is listed in the pharmaceutical additive standard. According to the Pharmaceutical Additives Standard (2018), when Nikazole TS-620 is evaporated to dryness on a water bath and then dried at 105 ° C. for 3 hours, the amount of evaporation residue is 57 to 61%.
In the above copolymer, by setting the proportion of the monomer A in which the Tg of the homopolymer is 270 K or more to 30% by mass or more and 50% by mass or less, improvement in the adhesive strength of the pressure-sensitive adhesive layer at the time of water dispersal can be expected. ..

In the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention, the blending amount of the acrylic acid alkyl ester-based copolymer emulsion is 20% by mass based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. It can be more than 70% by mass and 20% by mass or more and 60% by mass or less. The mixing ratio with the acrylic hydrophilic pressure-sensitive adhesive, which will be described later, can be, for example, an acrylic acid alkyl ester-based copolymer emulsion: acrylic-based hydrophilic pressure-sensitive adhesive = 5: 1 to 15: 1 in terms of mass ratio. ..
The blending amount (solid content equivalent amount) of the acrylic acid alkyl ester-based copolymer is, for example, 0.1% by mass or more and 40% by mass or less, based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. It can be 10% by mass or more and 37% by mass or less. The mixing ratio with the acrylic hydrophilic pressure-sensitive adhesive described later is, for example, in terms of mass ratio, acrylic acid alkyl ester-based copolymer (solid content equivalent amount): acrylic hydrophilic pressure-sensitive adhesive = 10: 1 to 1:10, The same = 5: 1 to 1: 5, the same = 3: 1 to 1: 2, the same = 2: 1 to 1: 1 and the like.

<Acrylic hydrophilic adhesive>
The pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention contains an acrylic hydrophilic pressure-sensitive adhesive.
Examples of the acrylic hydrophilic pressure-sensitive adhesive include water-soluble (meth) acrylic polymers. The water-soluble (meth) acrylic polymer is a polymer obtained by polymerizing a (meth) acryloyl group-containing monomer having a functional group (hydrophilic group) having water solubility, and can be blended with water in the pressure-sensitive adhesive layer. , Demonstrates adhesiveness. Examples of the water-soluble (meth) acrylic polymer include homopolymers such as polyacrylic acid and a neutralized product of polyacrylic acid; and copolymers such as N-vinylacetamide / sodium acrylate copolymer resin.
The polyacrylic acid neutralized product may be a completely neutralized product of polyacrylic acid, a partially neutralized product of polyacrylic acid, or a mixture thereof. The neutralized polyacrylic acid means a polyacrylic acid salt, and for example, sodium salt, potassium salt, calcium salt, ammonium salt and the like can be used.

The blending amount of the acrylic hydrophilic pressure-sensitive adhesive is, for example, 0.1% by mass or more and 10% by mass or less and 1% by mass or more and 8% by mass or less based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. can do.

<Crosslinking agent>
The pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention further contains a cross-linking agent. Examples of the cross-linking agent include polyvalent metal salts, and examples thereof include polyvalent metal compounds containing aluminum. As an example, hydroxides such as aluminum hydroxide and alumina magnesium hydroxide; aluminum chloride, aluminum sulfate, potassium aluminum sulfate, aluminum glycinate (dihydroxyaluminum aminoacetal), dihydroxyaluminum aminoacetate, synthetic aluminum silicate, dry hydroxide. Positive salts of inorganic or organic acids such as aluminum gel, kaolin and aluminum stearate or basic salts thereof; re-salts such as aluminum myoban; aluminate such as aluminate; inorganic aluminum complex salts and organic aluminum chelate compounds. Examples thereof include polyvalent metal compounds such as synthetic hydrotalcite, magnesium aluminate silicate, and magnesium aluminate metasilicate, and these can be used alone or in combination of two or more.

The amount of the cross-linking agent to be blended may be appropriately selected in consideration of the degree of cross-linking that may contribute to the residual adhesive on the skin and the adhesiveness. For example, the blending amount is, for example, 0.01% by mass or more and 6.0% by mass or less, 0.01% by mass or more and 4.0% by mass or less, based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. Alternatively, the range of 0.01% by mass or more and 2.0% by mass or less can be mentioned.

<Thickening agent>
The pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention contains a thickening agent, which is expected to function as improving the shape retention and the tackiness of the pressure-sensitive adhesive. Examples of the thickening agent include celluloses such as ethyl cellulose, sodium carmerol, hydroxyethyl cellulose, hydroxypropyl cellulose, hypromellose and methyl cellulose, polysaccharides such as sodium alginate, carrageenan, xanthan gum and sodium hyaluronate, gelatin and urea. Can be mentioned. Of these, carmellose sodium, which has thixotopy properties and improves ductility, is preferable. These can be used alone or in combination of two or more.
The blending amount of the thickening agent is usually, for example, 0.1% by mass or more and 10% by mass or less, 0.5% by mass or more and 20% by mass, based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. Below, or in the range of 1.0% by mass or more and 10% by mass or less.

<Wetting agent>
The pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention contains a wetting agent (also referred to as a moisturizing agent). The wetting agent has a function of suppressing evaporation of water over time, and can be directly mixed with water such as a water-soluble polymer such as a hydrophilic acrylic pressure-sensitive adhesive, a thickening agent such as carmellose sodium, and a cross-linking agent. It is expected to have a function of suppressing thickening due to lump generation and cross-linking. For the reason of avoiding the latter direct addition to water, it is desirable to use a wetting agent that contains almost no water. That is, at the time of forming the pressure-sensitive adhesive layer, the hydrophilic acrylic pressure-sensitive adhesive, the thickening agent, etc. By blending a cross-linking agent or the like to prepare a pre-formation and then mixing it with other components constituting the pressure-sensitive adhesive layer, lump generation and thickening can be suppressed. Examples of such wetting agents include concentrated glycerin, glycerin, D-sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, liquid paraffin, 1,3-propanediol, 1,4-butanediol, and martitol. , Polyhydric alcohols such as xylitol. These can be used alone or in combination of two or more.
In addition, for the reason of suppressing the evaporation of water over time of the former, a wetting agent containing water can be preferably blended. For example, the D-sorbitol solution, which is usually used as a 70% aqueous solution, contains water, so that it is difficult to use it for suppressing the generation of lumps and thickening (preparation of the above-mentioned preform), but it is mixed with other components thereafter. It is possible to mix them together.
The blending amount of the wetting agent (the total amount of the wetting agent containing almost no water and the wetting agent containing water) is usually set based on, for example, the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. It can be in the range of 0% by mass or more and 70% by mass or less, 5.0% by mass or more and 60% by mass or less, or 10% by mass or more and 60% by mass or less.
In addition, the total amount <A> of the above-mentioned hydrophilic acrylic pressure-sensitive adhesive, the thickening agent, and the cross-linking agent and the amount <B> mass ratio of the wetting agent containing almost no water (for example, concentrated glycerin) are set. By blending these as <A> / <B> = 7.25 / 25 to 7.25 / 10, it is preferable because it can be expected that lumps do not occur and uniform kneading can be performed.

<Water>
As described above, the non-pharmaceutical water-containing patch of the present invention contains water (moisture) in the pressure-sensitive adhesive layer. In the present specification, the "water" contained in the pressure-sensitive adhesive layer includes not only water separately added as water at the time of forming the pressure-sensitive adhesive layer, but also water contained in the form of an emulsion or an aqueous solution.
The blending amount of water is not particularly limited, but based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch, for example, 10% by mass or more and 90% by mass or less, 15% by mass or more and 70% by mass or less, 20% by mass. It can be in the range of 50% by mass or less. It should be noted that this water content is a value at the time of preparing the patch or before the patch is applied, and is not limited to the case where water volatilizes from the adhesive layer with the progress of the application.

<Refreshing agent>
In the non-pharmaceutical water-containing patch of the present invention, a cooling agent can be added to the pressure-sensitive adhesive layer. Examples of the refreshing agent include l-menthol, dl-camphor, kehi oil, geraniol, peppermint oil, bergamot oil, d-borneol, eucalyptus oil and the like, and these may be used alone or in combination of two or more. can.
When a refreshing agent is blended, the blending amount may be appropriately selected in consideration of developing a refreshing sensation at the time of application. For example, the blending amount of l-menthol as a refreshing agent is, for example, 0.01% by mass or more and 4.0% by mass or less, 0.01% by mass, based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. The range of% or more and 3.0% by mass or less can be mentioned.

<Organic solvent>
The pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention may further contain an organic solvent. The organic solvent blended in the pressure-sensitive adhesive layer may have a role of assisting the dissolution of each compounding component and preventing the precipitation of each compounding component from the pressure-sensitive adhesive layer. As such an organic solvent (solubilizing agent), crotamitone; N-methyl-2-pyrrolidone; polyalkylene glycol such as macrogol 400 (polyethylene glycol) and polybutylene glycol; diethyl adipate, diisopropyl adipate, diethyl sebacate , Fatty esters such as diisopropyl sebacate, isopropyl myristate, isopropyl palmitate, oleyl oleate; sorbitan esters such as polyoxyalkylene fatty acid esters; polyhydric alcohols such as 1,3-butanediol; dimethylformamide; dimethylsulfoxide, etc. Can be mentioned. These can be used alone or in combination of two or more.

The blending amount of the organic solvent is, for example, 0.1% by mass or more and 20% by mass or less, 0.5% by mass or more and 10% by mass or less, or 1 based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. It can be in the range of 0.0% by mass or more and 5% by mass or less.

<pH regulator>
The pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention may further contain a pH adjuster. As the pH adjuster, either an organic acid or an inorganic acid can be used, and these may be used in combination.
Examples of the organic acid include citric acid, lactic acid, tartrate acid, gluconic acid, glycolic acid, malic acid, fumaric acid, metasulfonic acid, maleic acid, acetic acid and the like, and these may be used alone or in combination of two or more. Can be done. Of the organic acids, hydroxy acids such as lactic acid also have the effect of improving the solubility of the sparingly soluble aluminum compound (crosslinking agent).
Examples of the inorganic acid include hydrochloric acid, boric acid, phosphoric acid, sulfuric acid and the like, and these can be used alone or in combination of two or more.
The blending amount of the organic acid can be, for example, in the range of 0.01% by mass or more and 5% by mass or less based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch.
The blending amount of the inorganic acid can be, for example, in the range of 0.1% by mass or more and 1.2% by mass or less based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch.

<Chelating agent>
A chelating agent can be added to the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention in order to control the dissolution rate of the poorly soluble aluminum compound (crosslinking agent).
Examples of the chelating agent include sodium edetate (ethylenediaminetetraacetic acid disodium salt).
The blending amount of the chelating agent is usually in the range of 0.01% by mass or more and 1% by mass or less based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch.

<Other optional ingredients>
In the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention, as other optional components other than the above, a water-soluble polymer compound, a surfactant, a stabilizer (antioxidant, an ultraviolet absorber, etc.), an inorganic substance, etc. Ingredients that can be generally blended in the pressure-sensitive adhesive layer of conventional water-containing patches (pups) or non-aqueous patches (tapes), such as powders, colorants, fragrances, and preservatives, can be blended. These optional components can be used alone or in combination of two or more.

<Water-soluble polymer compound>
Examples of the water-soluble polymer compound include polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, sucrose fatty acid ester and the like. These can be used alone or in combination of two or more.
The blending amount of the water-soluble polymer compound is usually 1.0% by mass or more and 30% by mass or less and 3.0% by mass or more and 20% by mass based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. It can be in the range of% or less, or 5.0% by mass or more and 20% by mass or less.

<Surfactant>
Examples of the surfactant include polyoxyethylene fatty acid esters such as polyoxyethylene monolaurate, polyoxyethylene monostearate, polyoxyethylene monooleate, polyethylene glycol distearate, polyethylene glycol dilate, and polypropylene glycol dioleate. Sorbitan monocaprylate, sorbitan monolaurate, sorbitan monomillistate, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, sorbitan tristearate, sorbitan monoolate, sorbitan triolate, sorbitan monosesquiolate, and Solbitan fatty acid esters such as these polyethylene oxide adducts; polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monooleate, Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan triolate and polyoxyethylene sorbitan triisostearate; polyoxyethylene dodecyl ether (polyoxyethylene lauryl ether), polyoxyalkylene lauryl ether, polyoxyethylene tridecyl ether, Polyoxyalkylene tridecyl ether, polyoxyethylene myristyl ether, polyoxyethylene cetyl ether, polyoxyethylene oleyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene-2-ethylhexyl ether, polyoxyethylene iso Polyoxyethylene alkyl ethers such as decyl ether; polyoxyethylene alkylphenol ethers such as polyoxyethylene styrene phenyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene disstyrene phenyl ether, and polyoxyethylene tribenzylphenyl ether; Glycerin fatty acid esters such as glycerin stearate and glycerin monooleate; nonionic surfactants such as polyethylene glycol, polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil and lecithin can be mentioned. These can be used alone or in combination of two or more.
The blending amount of these surfactants is, for example, 0.001% by mass or more and 10% by mass or less, 0.01% by mass or more and 5% by mass or less, based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch. Can be a range.

<Stabilizer>
A stabilizer can be added to the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention in order to improve the storage stability of the ingredients against light (particularly ultraviolet rays), heat or oxygen. ..
Examples of the stabilizer include an antioxidant such as dibutylhydroxytoluene (BHT); an ultraviolet absorber such as a benzoylmethane derivative; and the like.
The blending amount of the stabilizer is usually in the range of 0.01% by mass or more and 1% by mass or less based on the total mass of the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch.

<Inorganic powder>
As the inorganic powder, calcium carbonate, magnesium carbonate, silicate, zinc oxide, titanium oxide, magnesium sulfate, calcium sulfate and the like can be blended.

[Support]
Examples of the support used for the non-pharmaceutical water-containing patch of the present invention include flexible supports such as films, non-woven fabrics, Japanese papers, cotton cloths, knitted fabrics, woven fabrics, and laminated composites of non-woven fabrics and films. These supports are preferably made of a flexible material that can adhere to the skin and can follow the movement of the skin, and a material that can suppress the occurrence of skin irritation after long-term application. Examples of the material of these supports include polyethylene, polypropylene, polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polystyrene, nylon, cotton, acetate rayon, rayon, rayon / polyethylene terephthalate composite, polyacrylonitrile, polyvinyl alcohol, and the like. Acrylic polyurethane, ester polyurethane, ether polyurethane, styrene-isoprene-styrene copolymer, styrene-butadiene-styrene copolymer, styrene-ethylene-propylene-styrene copolymer, styrene-butadiene rubber, ethylene-vinyl acetate Examples thereof include copolymers, cellophane and the like as essential components.

In addition, the support such as cloth can be colored with a colorant to a color tone such as skin color to reduce the difference from the skin color at the time of application. Further, in that the color tone of the skin under the application can be easily seen through, the form of a plastic film having excellent transparency can be adopted.

The thickness of the support is usually about 5 μm to 1 mm. When the support is a cloth, its thickness is preferably 50 μm to 1 mm, more preferably 100 to 800 μm, and further preferably 200 to 700 μm. When the support is a plastic film, its thickness is preferably 10 to 300 μm, more preferably 12 to 200 μm, and even more preferably 15 to 150 μm. When the thickness of the support is as thin as about 5 μm to 30 μm, if a peelable carrier film layer is provided on the surface opposite to the pressure-sensitive adhesive layer formed on the support, the handleability as a patch can be improved. It is preferable because it improves. However, if the thickness of the support is smaller than 5 μm, the strength and handleability of the patch will decrease, making it difficult to stick to the skin, tearing due to contact with other members, or with water for bathing, etc. It may peel off from the skin in a short time due to contact. In addition, if the thickness of the support is too large (more than 1 mm), it becomes difficult for the patch to follow the movement of the skin, and it becomes easy to form a trigger for peeling off at the edge of the patch, so that the patch can be peeled off from the skin in a short time. There is a risk of peeling or an increase in discomfort during application.
When the support is a film, one or both sides of the support may be sandblasted, corona-treated, or the like for the purpose of improving the anchoring property of the adhesive and the support.
Further, in order to facilitate removal from the packaging material, unevenness may be provided on one side or both sides of the support by a method other than sandblasting.

[Peeling liner]
The release liner (also referred to as release layer / release paper) used in the non-pharmaceutical water-containing patch of the present invention is preferably made of a material that does not easily absorb or adsorb drugs or the like in the pressure-sensitive adhesive layer. Conventional ones can be used in the field.
For example, plastic films such as polyester (polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, etc.), polypropylene (non-stretched, stretched, etc.), polyethylene, polyurethane, polyvinyl chloride, polystyrene, etc .; high-quality paper, glassin paper, parchment paper, craft Paper such as paper and synthetic paper; peeling processed paper in which the plastic film, paper or synthetic paper, synthetic fiber and the like are coated with a release agent having peeling performance such as silicone resin and fluororesin; aluminum foil; various films and sheets are used. Examples thereof include colorless or colored sheets such as laminated laminated paper and laminated peeled paper obtained by coating the laminated paper with a release agent. The release liner can also be provided with irregularities so that it can be easily taken out from the packaging material.
The thickness of these release liners is not particularly limited, but is usually in the range of 10 μm to 1 mm, for example, 20 μm to 500 μm, preferably 40 μm to 200 μm.
The shape of the release liner can be a square, a rectangle, a circle, or the like, and if desired, a shape with rounded corners can be used. The size may be the same as or slightly larger than the size of the support in the patch. The peeling liner may be composed of one or a plurality of strips, and the cut may be formed of a straight line, a wavy line, or a sewing machine line, or a part of the peeling liners may overlap each other.

[Manufacturing method of non-pharmaceutical water-containing patch]
The non-pharmaceutical water-containing patch of the present invention can be produced by a conventionally known method. For example, it can be manufactured through the following steps i) or ii).
i) A step of applying the pressure-sensitive adhesive layer forming composition on the support to form the pressure-sensitive adhesive layer, and a step of bonding the pressure-sensitive adhesive layer formed on the support and the release liner.
ii) A step of applying the pressure-sensitive adhesive layer forming composition on the release liner to form the pressure-sensitive adhesive layer, and a step of bonding the pressure-sensitive adhesive layer formed on the release liner and the support.
The thickness of the pressure-sensitive adhesive layer is not particularly limited, but is usually 10 μm to 1000 μm, for example, about 20 μm to 800 μm.

The pressure-sensitive adhesive layer-forming composition includes various components contained in the above-mentioned pressure-sensitive adhesive layer: acrylic hydrophilic pressure-sensitive adhesive, acrylic acid alkyl ester-based copolymer, cross-linking agent, thickening agent, wetting agent, and water. It is a semi-solid composition which may contain a cooling agent, an organic solvent, a pH adjuster and a chelating agent, and may further contain any other component.
It is preferable to set the pH of the pressure-sensitive adhesive layer forming composition to 2 to 4 because good crosslinkability and shape retention can be expected.

The non-pharmaceutical water-containing patch of the present invention is characterized in that the adhesive strength is maintained when it contains water (immediately after application) and when it does not contain water (after the water volatilizes after application), and it also has skin irritation. It is a low patch.
For example, the pressure-sensitive adhesive layer of the non-pharmaceutical water-containing patch of the present invention has i) a peel adhesive strength of 1 N / 15 mm or more after storage at 50 ° C. for 16 hours from the date of manufacture of the patch, and ii) the patch. Immediately after the manufacture of the adhesive, it has a probe tack of 0.7 N / mmφ or more, and iii) the probe tack value of the pressure-sensitive adhesive layer immediately after the manufacture of the patch is 50 ° C. for 16 hours from the date of manufacture of the patch. It is preferable that the pressure-sensitive adhesive layer has an adhesive strength such that the probe tack value after storage is 1.8 times or more.

The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these examples.

<Making a patch>
The patches of Examples and Comparative Examples were manufactured by the following procedure.

Example 1:
1 part by mass of polyvinyl alcohol was dissolved in 10 parts by mass of purified water by heating at 70 ° C., and then cooled to room temperature (preliminary preparation 1).
Next, 3 parts by mass of Macrogol (registered trademark) 400 and 1 part by mass of lactic acid were added to 1 part by mass of l-menthol, dissolved at 40 ° C., and then cooled to room temperature (preliminary preparation 2).
Further, 4 parts by mass of the partially neutralized polyacrylic acid, 3 parts by mass of sodium carmellose, and 0.25 parts by mass of dihydroxyaluminum aminoacetate were uniformly dispersed in 25 parts by mass of concentrated glycerin (preliminary preparation 3).
In a stirrer, preform 1, methyl acrylate / 2-ethylhexyl acrylate copolymer emulsion (solid content 60%, polyoxyethylene nonylphenyl ether (30EO) trace amount contained in the emulsion), 20 parts by mass, sodium edetate water. 0.2 parts by mass of Japanese product, 25 parts by mass of D-sorbitol 70% aqueous solution and 0.4 parts by mass of hydrochloric acid were added in this order, and the mixture was uniformly dispersed or dissolved under degassing conditions. The pre-formal product 2 was added thereto and kneaded uniformly under degassing conditions. Further, the preform 3 is added, the mass is corrected with purified water so as to have a total of 100 parts by mass, and then the mixture is uniformly kneaded under degassing conditions to obtain the pressure-sensitive adhesive layer forming composition (plaster) of Example 1. Obtained.
The obtained pressure-sensitive adhesive layer-forming composition is spread on the silicone surface of a liner (pete (75 μm) treated with silicone on one side) with a spreading machine adjusted to a slit width of 0.5 mm, and a knit support (made of polyester) is formed. After laminating, it was punched into an arbitrary shape, sealed in an aluminum bag, and aged at 40 ° C. for 1 week to obtain the formulation of Example 1.

Example 2:
Same as Example 1 except that the amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer emulsion was changed to 30 parts by mass (solid content 60%) and the amount of the D-sorbitol 70% aqueous solution was changed to 20 parts by mass. The preparation of Example 2 was obtained.

Example 3:
Same as Example 1 except that the compounding amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer emulsion was changed to 40 parts by mass (solid content 60%) and the compounding amount of the 70% aqueous solution of D-sorbitol was changed to 15 parts by mass. The preparation of Example 3 was obtained.

Example 4:
The amount of methyl acrylate / 2-ethylhexyl acrylate copolymer compounded emulsion is 50 parts by mass (solid content 60%), the amount of D-sorbitol 70% aqueous solution is 10 parts by mass, and the amount of concentrated glycerin is 20 parts by mass. The pharmaceutical product of Example 4 was obtained in the same manner as in Example 1 except that it was changed.

Example 5:
The amount of methyl acrylate / 2-ethylhexyl acrylate copolymer compounded emulsion is 60 parts by mass (solid content 60%), the amount of D-sorbitol 70% aqueous solution is 0 parts by mass, and the amount of concentrated glycerin is 20 parts by mass. The pharmaceutical product of Example 5 was obtained in the same manner as in Example 1 except that it was changed.

Comparative Example 1:
A pharmaceutical product of Comparative Example 1 was obtained in the same manner as in Example 1 except that the blending amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer emulsion was changed to 7 parts by mass (solid content 60%).

Comparative Example 2:
A pharmaceutical product of Comparative Example 2 was obtained in the same manner as in Example 1 except that the blending amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer emulsion was changed to 10 parts by mass (solid content 60%).

Comparative Example 3:
The amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer emulsion was changed to 70 parts by mass (solid content 60%), the amount of the D-sorbitol solution was changed to 0 parts by mass, and the amount of concentrated glycerin was changed to 10 parts by mass. Except for the above, an attempt was made to obtain a pressure-sensitive adhesive layer-forming composition in the same manner as in Example 1, but a large amount of lumps were generated in the obtained pressure-sensitive adhesive layer-forming composition, and the subsequent spread to the liner was not achieved. The formulation could not be obtained.

Test Example 1 (Adhesive layer (adhesive layer forming composition (plaster))
With respect to the formulations of Examples 1 to 5 and Comparative Examples 1 and 2 when they contained water (after aging) and when they did not contain water (after aging, the liner was peeled off to expose the pressure-sensitive adhesive layer). After drying at 50 ° C. for 16 hours), the color of the pressure-sensitive adhesive layer (the pressure-sensitive adhesive layer forming composition) was visually evaluated. The results obtained are shown in Table 2.

Test Example 2 (Cross-linked state of adhesive layer (adhesive layer forming composition (plaster)))
The formulations (after aging) of Examples 1 to 5 and Comparative Examples 1 to 3 were cut into 1 cm × 5 cm and immersed in 50 mL of purified water at room temperature (23 ° C. ± 5 ° C.). After 16 hours from the immersion, the swelling state of the pressure-sensitive adhesive layer (the pressure-sensitive adhesive layer forming composition) was visually evaluated, and the cross-linked state of the pressure-sensitive adhesive layer (the pressure-sensitive adhesive layer forming composition) was evaluated according to the following evaluation criteria. The results obtained are shown in Table 2.
<Evaluation criteria>
-: No cross-linking (adhesive layer (adhesive layer forming composition) dissolved)
+: Cross-linked (adhesive layer (adhesive layer forming composition) does not dissolve and swells greatly)
++: Strong cross-linking (adhesive layer (adhesive layer forming composition) does not dissolve and swells moderately)
+++: Very strong cross-linking (adhesive layer (adhesive layer forming composition) does not dissolve and swells small)
In addition, the pressure-sensitive adhesive layer-forming composition evaluated as “-” (without cross-linking) may dissolve a polymer compound such as a hydrophilic acrylic pressure-sensitive adhesive, and as the dissolution progresses, it may be deposited on the bottom of the immersed container. On the other hand, as the evaluation changes from "+" to "+++", the swelling of the polymer compound decreases, and it can be confirmed that the pressure-sensitive adhesive layer-forming composition is in a strong crosslinked state.

Test Example 3 (Adhesive strength test)
<Test product>
For the formulations of Examples 1 to 5, Comparative Example 1 and Comparative Example 2, water-containing (after aging) and water-free (after aging, the liner was removed to expose the pressure-sensitive adhesive layer, and the temperature was 50 ° C. for 16 hours. After drying in storage), the two types were set as the initial stage.
In addition, the "moisture-containing" preparations (after aging and in an aluminum bag) of Examples 1 to 5, Comparative Example 1 and Comparative Example 2 were stored at 60 ° C. for 1 week.
The following tests 1) to 3) were carried out for the "initial" (moisture-containing, moisture-free) and "60 ° C. for 1 week storage" (moisture-containing) of all the above-mentioned preparations.

<Adhesive strength test>
1) Ball tack adhesive strength test: Japan-wide general test method 6.12 Adhesive strength test method 3.2 The ball tack test method was carried out according to the tilted ball tack test method.
2) Peel adhesive strength test: Japan-wide general test method 6.12 Adhesive strength test method 3.1 The peel adhesive strength test method was carried out.
3) Probe tack adhesive strength test: Japan-wide general test method 6.12 Adhesive strength test method 3.4 The probe tack test method was carried out.
The results obtained are shown in Table 3.

<Test results (Table 2)>
As shown in Table 2, a pressure-sensitive adhesive layer-forming composition containing 7% by mass to 60% by mass of a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion (Nicazole) (Examples 1 to 5, Comparative Example 1). In (2), the preparation could be produced without causing lumps during production. Further, as the blending amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion increased, the color of the pressure-sensitive adhesive layer forming composition became cloudy. The white turbidity of the pressure-sensitive adhesive layer-forming composition disappears due to the volatilization of water, and in all the formulations prepared in the range of 7% by mass to 60% by mass of the 2-ethylhexyl acrylate copolymer resin emulsion, after drying. The color of the pressure-sensitive adhesive layer-forming composition became transparent.
On the other hand, as described above, the pressure-sensitive adhesive layer-forming composition of Comparative Example 3 in which the blending amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion was increased to 70% by mass caused a large amount of lumps to be generated in the formulation. It was impossible to manufacture.

Further, it was confirmed that the pressure-sensitive adhesive layer-forming composition in which the amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion was 7% by mass to 60% by mass was crosslinked, and the amount of the emulsion was increased. As a result, the cross-linked state tended to become stronger.

As shown in Table 3, in the results of ball tack adhesive strength, the formulations of Examples 1 to 5 were No. 1 in terms of water content (initial stage). The number was 21 or more, and no decrease with time was observed. In addition, the ball tack adhesive strength after the water volatilized tended to increase from the time when the water volatilized.
On the other hand, the formulations of Comparative Examples 1 and 2 decreased with time when they contained water, and at 60 ° C. and 1 W, No. It was 17 or less.

In addition, as a result of the peel adhesive strength, the formulations of Examples 1 to 5 showed 1 N / 15 mm or more after the water volatilization, and depended on the blending amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion. Therefore, the value of peel adhesive strength increased.
On the other hand, in the formulations of Comparative Example 1 to Comparative Example 2, the peel adhesive strength was less than 1N / 15 mm even after the water volatilized.

Further, as a result of the probe tack adhesive strength, the formulations of Examples 1 to 5 showed 1 N / 5 mmφ or more after the water volatilization, and depended on the blending amount of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion. As a result, the value of probe tack adhesive strength increased.
In the formulations of Comparative Example 1 to Comparative Example 2, the probe tack adhesive strength after water volatilization exceeded 1 N / 5 mmφ, but the value was lower than that of the examples.

From the above results, the formulations of Examples 1 to 5 are higher in both water-containing and water-free (after water volatilization) in the ball tack and probe tack than the formulations of Comparative Examples 1 and 2. The value was shown, and the peel adhesive strength was significantly higher than that after the water volatilization.
As described above, based on the results of Examples, according to the present invention, the blending amount of the acrylic acid alkyl ester-based copolymer emulsion is 20% by mass or more and less than 70% by mass with respect to the total mass of the pressure-sensitive adhesive layer, thereby containing water. It was confirmed that it is possible to provide a non-pharmaceutical water-containing patch having low skin irritation while maintaining high adhesiveness during time and drying.

Claims

A non-pharmaceutical water-containing patch comprising a support, an adhesive layer provided on the support, and a release liner.
The pressure-sensitive adhesive layer
1) Acrylic hydrophilic adhesive,
2) Acrylic acid alkyl ester-based copolymer emulsion,
3) Crosslinking agent,
4) Condensing agent,
5) a wetting agent containing a wetting agent containing almost no water, and 6) a wetting agent containing water,
The acrylic acid alkyl ester copolymer is a copolymer of a monomer mixture composed of monomer A and monomer B.
The monomer A is a polymer having a glass transition temperature (Tg) of 270 K or higher when the monomer A is homopolymerized.
The monomer B is a polymer having a glass transition temperature (Tg) of 220 K or less when the monomer B is homopolymerized.
The acrylic acid alkyl ester-based copolymer emulsion is contained in a proportion of 20% by mass or more and less than 70% by mass with respect to the total mass of the pressure-sensitive adhesive layer.
Water-containing patch for non-pharmaceutical products.
The water-containing patch for non-pharmaceutical products according to claim 1, which comprises one or more of the following (a) to (c).
a) The acrylic acid alkyl ester-based copolymer is an acrylic acid alkyl ester-based copolymer in which the proportion of the monomer A is 30% by mass or more and 50% by mass or less with respect to the total mass of the monomer mixture. ..
b) The pressure-sensitive adhesive layer has a pH of 2 to 4.
c) The mass ratio of the total amount of the hydrophilic acrylic pressure-sensitive adhesive, the thickening agent, and the cross-linking agent to the amount of the wetting agent containing almost no water is (total amount) / (the above). Wetting agent) = 7.25 / 25 to 7.25 / 10.
The wetting agent containing almost no water is concentrated glycerin, glycerin, D-sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, liquid paraffin, 1,3-propanediol, 1,4-butanediol, and martitol. , And the non-pharmaceutical water-containing patch according to claim 1 or 2, selected from the group consisting of xylitol.
The pressure-sensitive adhesive layer is
It has a peel adhesive strength of 1N / 15 mm or more after storage at 50 ° C. for 16 hours from the date of manufacture of the patch.
Immediately after the patch is manufactured, it has a probe tack of 0.7 N / mmφ or more and has a probe tack.
The probe tack value of the pressure-sensitive adhesive layer immediately after the production of the patch is 1.8 times or more the probe tack value of the pressure-sensitive adhesive layer after storage at 50 ° C. for 16 hours from the date of manufacture of the patch.
The water-containing patch for non-pharmaceutical products according to any one of claims 1 to 3.
The pressure-sensitive adhesive layer is further 7) a cooling agent 8) an organic solvent,
9) pH regulator,
10) Chelating agent,
The water-containing patch according to any one of claims 1 to 4, which comprises.