WO2022041353A1 - 一种抗应激饲料添加剂及其制备方法、应用 - Google Patents

一种抗应激饲料添加剂及其制备方法、应用 Download PDF

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WO2022041353A1
WO2022041353A1 PCT/CN2020/116379 CN2020116379W WO2022041353A1 WO 2022041353 A1 WO2022041353 A1 WO 2022041353A1 CN 2020116379 W CN2020116379 W CN 2020116379W WO 2022041353 A1 WO2022041353 A1 WO 2022041353A1
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stress
feed additive
feed
stress feed
group
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PCT/CN2020/116379
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French (fr)
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王振华
杨锴
崔一
赵素娟
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河北科星药业有限公司
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/02—Breeding vertebrates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry

Definitions

  • the invention belongs to the field of animal feed additives, and relates to a feed additive, in particular to an anti-stress feed additive and a preparation method and application thereof.
  • Stress refers to the non-specific response of livestock and poultry to external stimuli. In the process of raising livestock and poultry, when encountering factors such as climate change, immunization, circle grouping, beak capture, high temperature and water shortage, it will lead to the occurrence of stress response, which will affect the growth and development, egg production and meat quality of livestock and poultry. cause adverse effects.
  • the Chinese invention patent with publication number CN 105519816B discloses an additive for improving the anti-stress ability of laying hens.
  • the additive of the invention is added with Chinese herbal medicines that are relatively expensive and affect palatability, and vitamins and amino acids with poor stability.
  • Substances for immunity of laying hens have the problems of poor palatability, high production cost and poor stability. Therefore, there is an urgent need to develop an anti-stress feed additive with good product palatability, low production cost and good stability.
  • the purpose of the present invention is to provide an anti-stress feed additive to solve the problems of poor palatability, poor stability and high production cost of feed additives in the prior art;
  • Another object of the present invention is to provide a preparation method of the above-mentioned anti-stress feed additive
  • Another object of the present invention is to provide an application of the above-mentioned anti-stress feed additive.
  • An anti-stress feed additive the raw materials for making its active ingredients include: arginine, lysine and histidine.
  • the raw materials for making its active ingredients include: 50-70 parts of arginine, 15-25 parts of lysine, and 10-15 parts of histidine.
  • the raw materials for making its active ingredients include: 66.7 parts of arginine, 22.2 parts of lysine, and 11.1 parts of histidine.
  • the invention also provides a preparation method of the above-mentioned anti-stress feed additive, which can be prepared by mixing all the raw materials and sieving.
  • the sieving particle size in the preparation process is 65-100 mesh, and the prepared anti-stress feed additive can be easily mixed and proportioned with the feed, and easily digested and absorbed by the body.
  • the present invention also provides an application of the above anti-stress feed additive, which is to add the anti-stress feed additive to the basal diet for alleviating the stress response of chickens.
  • the application is 1-5 days before the occurrence of stress conditions (such as vaccination, group transfer or beak cutting) or for 5-10 consecutive days from the day when the stress occurs.
  • stress conditions such as vaccination, group transfer or beak cutting
  • the added amount of the anti-stress feed additive during the application process is 0.05-0.15% of the weight of the basic diet.
  • the added amount of the anti-stress feed additive during the application process is 0.1% of the weight of the basic diet.
  • Arginine is a basic amino acid, an essential amino acid for protein synthesis in animals, the direct precursor of nitric oxide, urea, ornithine and myobutylamine, and the synthesis of myosin
  • arginine can regulate the growth of the body by regulating the endocrine pathway of the body.
  • arginine can directly stimulate the body to secrete growth hormone and insulin, and it can also generate ornithine through metabolism, and then generate glutamic acid, which promotes The release of growth hormone, in the state of immature development and infection, the body needs a large amount of arginine, supplementing an appropriate amount of arginine can effectively promote protein synthesis, enhance tissue repair, and inhibit inflammation; animal stress state It will induce the activation of nitric oxide synthase, synthesize a large amount of nitric oxide, produce cytotoxicity, and consume a large amount of arginine, resulting in nutritional deficiency. At this time, supplementing arginine can regulate the metabolism of arginine and maintain arginine. Endogenous stability, regulation of endocrine, and inhibition of inflammation, thereby alleviating stress response and reducing losses;
  • Histidine is a semi-essential amino acid and a basic amino acid. It has a certain effect on the absorption and metabolism of other nutrients and muscle development. Animals, especially young animals, have strong growth and metabolism. It cannot be synthesized by itself, and has a large nutritional demand for histidine. If it is not replenished in time, it is easy to suffer from a lack of histidine, which affects its growth; in addition, histidine can also reduce the acidity of gastric juice and inhibit autonomic nervousness. Digestive tract ulceration, relieve stress response;
  • Lysine is an essential basic amino acid, which can promote growth and development, help produce antibodies, hormones and enzymes, enhance immune function, and improve central nervous tissue function; lysine can improve gastric secretion. , enhance appetite, promote amino acid absorption, and improve the situation of animal feed intake and immunity under stress conditions;
  • arginine, lysine and histidine added in the present invention are all basic amino acids, and all three basic amino acids can be directly absorbed by the body, and can neutralize acidic substances in blood and tissues, Plays a chemical buffering effect, thereby alleviating the stress response;
  • the anti-stress feed additive prepared by the sieving mesh selected by the preparation method of the present invention has a particle size that makes it easy to mix with the feed, and is also easy to be digested and absorbed by the body;
  • the present invention only prepares anti-stress feed additives by adding arginine, lysine and histidine, and does not add Chinese herbal medicines that are expensive and affect palatability and vitamins with poor stability, and the preparation method is simple, The production cost is low, and the prepared anti-stress feed additive has good palatability and stability;
  • the present invention uses three basic amino acids of arginine, lysine and histidine as raw materials to prepare anti-stress feed additives. Growth and development, and improve feed utilization rate; the preparation method of the invention is simple, the production cost is low, and the prepared anti-stress feed additive has good palatability and stability.
  • the invention is suitable for preparing an anti-stress feed additive, which is suitable for chickens and other poultry to eat.
  • Embodiment 1 A kind of preparation method of anti-stress feed additive
  • This example is a preparation method of an anti-stress feed additive. Weigh 66.7 kg of arginine, 22.2 kg of lysine, and 11.1 kg of histidine respectively, mix them evenly, and pass through a 65-mesh sieve to prepare anti-stress Feed additives, labeled M1.
  • Examples 2-8 are respectively a preparation method of an anti-stress feed additive, and their preparation steps are basically the same as those in Example 1, and the difference is only in the amount of raw materials and process parameters, as shown in the following table:
  • the anti-stress feed additives M1-M8 provided in Examples 1-8 were respectively added to the common commercial chicken feed (compound feed for laying hens during the peak period), and the mixed chicken feed was marked as AM1-AM8 in one-to-one correspondence.
  • the added amount of anti-stress feed additives M1-M8 is 0.1% of the weight of ordinary commercial chicken feed (compound feed for laying hens at the peak period); the anti-stress feed additive M1 provided in Example 1 is added to the ordinary market.
  • the added amount of M1 is 0.05% and 0.15% of the weight of ordinary commercial chicken feed (compound feed during the peak period of laying hens), respectively.
  • the mixed chicken feeds are one by one. Correspondingly marked AM9 and AM10.
  • Hylan brown laying hens were selected and randomly divided into 11 groups with 250 hens in each group. They were the control group and the experimental group A1-A10. The control group was fed with common commercial chicken feed (peak laying hens). Groups A1-A10 were fed with AM1-AM10 chicken feed respectively, and were fed unlimited amounts throughout the day; the Hailan brown laying hens in this experiment were raised in the same house, and the feeding and management methods such as lighting and drinking water were consistent. The Hylan brown laying hens in this test were vaccinated at the age of 199 days (new tributaries, intramuscular injection in the chest), and the egg production rate before and after the immunization was counted. The results are shown in Table 2:
  • the anti-stress feed additives M1-M8 provided in Examples 1-8 were respectively added to the common commercial chicken feed (broiler chicken compound feed), and the mixed chicken feed was marked as BM1-BM8 in one-to-one correspondence.
  • the addition amount of the stress feed additives M1-M8 is 0.1% of the weight of the common commercially available chicken feed (broiler chick compound feed); the anti-stress feed additive M1 provided in Example 1 is added to the common commercially available chicken feed (broiler chick feed).
  • the addition amount of M1 was 0.05% and 0.15% of the weight of ordinary commercial chicken feed (broiler chicken compound feed) respectively, and the mixed chicken feed was marked as BM9 and BM10 in one-to-one correspondence.
  • AA broilers 1100 5-day-old AA broilers were selected and randomly divided into 11 groups, 100 in each group, the control group and the experimental group B1-B10 groups, of which the control group was fed ordinary commercial chicken feed (broiler chick compound feed), B1- Group B10 was fed BM1 ⁇ BM10 chicken feeds respectively, with unlimited feeding throughout the day; the AA broilers in this experiment were raised in the same house, and the feeding and management methods such as lighting and drinking water were the same; the AA broilers in this experiment were 7-day-old The new vaccine was injected intramuscularly, and the body weight before and after immunization was counted. The results are shown in Table 3:
  • Table 3 The average body weight (g) of each group before and after immunization
  • Example 10 The palatability test of anti-stress feed additives
  • the anti-stress feed additives M1-M8 provided in Examples 1 to 8 were respectively added to ordinary commercial chicken feed (chicken compound feed), and the mixed chicken feed was marked as CM1-CM8 in one-to-one correspondence.
  • the addition amount of feed additives M1-M8 is 0.1% of the weight of common commercially available chicken feed (chick compound feed); the anti-stress feed additive M1 provided in Example 1 is added to common commercially available chicken feed (chick compound feed) Among them, the addition amount of M1 is 0.05% and 0.15% of the weight of common commercial chicken feed (chick compound feed) respectively, and the mixed chicken feed is marked as CM9 and CM10 in one-to-one correspondence.
  • 1100 5-day-old AA broilers were selected and randomly divided into 11 groups, 100 in each group, the control group and the experimental group BC1-BC10 groups, of which the control group was fed with ordinary commercial chicken feed (chicken compound feed, 50Kg/bag). (net content)), B1 ⁇ B10 groups were fed SCM1 ⁇ SCM10 chicken feed respectively, chickens in each group were fed 5Kg feed at 8:00 a.m.

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Abstract

一种抗应激饲料添加剂及其制备方法、应用，属于动物饲料加工领域。以精氨酸、赖氨酸、组氨酸三种碱性氨基酸为原料，经混合、过筛制得所述抗应激饲料添加剂，三种碱性氨基酸相互配合，协同缓解应激反应，促进动物生长发育，提高饲料利用率；所述制备方法简单、生产成本低廉，制得的抗应激饲料添加剂适口性、稳定性良好，适用于鸡食用，用于缓解应激反应。

Description

一种抗应激饲料添加剂及其制备方法、应用 技术领域
本发明属于动物饲料添加剂领域，涉及一种饲料添加剂，具体地说是一种抗应激饲料添加剂及其制备方法、应用。
背景技术
应激是指畜禽对外界因素刺激所产生的非特异性反应。在畜禽饲养过程中，遇到气候骤变、免疫接种、转圈分群、捕捉断喙、高温缺水等因素时会导致应激反应的发生，对畜禽生长发育、产蛋及肉品质均会造成不良影响。
公开号为CN 105519816B的中国发明专利公开了一种提高蛋鸡抗应激能力的添加剂，该发明的添加剂中添加了价格较高且影响适口性的中草药、稳定性较差的维生素、氨基酸和改善蛋鸡免疫力的物质，存在适口性差、生产成本高、稳定性差的问题。因此，急需研发一种产品适口性良好、生产成本低廉、且稳定性良好的抗应激饲料添加剂。
发明内容
本发明的目的，是要提供一种抗应激饲料添加剂，以解决现有技术中饲料添加剂适口性差、稳定性差、生产成本高的问题；
本发明的另一个目的，是要提供上述抗应激饲料添加剂的一种制备方法；
本发明还有一个目的，是要提供上述抗应激饲料添加剂的一种应用。
为实现上述目的，本发明所采用的技术方案如下：
一种抗应激饲料添加剂，制成它的有效成分的原料包括：精氨酸、赖氨酸、组氨酸。
作为本发明的一种限定，以重量份数计，制成它的有效成分的原料包括：精氨酸 50-70份、赖氨酸15-25份、组氨酸10-15份。
作为本发明的另一种限定，以重量份数计，制成它的有效成分的原料包括：精氨酸66.7份、赖氨酸22.2份、组氨酸11.1份。
本发明还提供了上述抗应激饲料添加剂的一种制备方法，取所有原料混合、过筛即可制得。
作为本发明制备方法的一种限定，制备过程中的过筛的筛分粒度为65-100目，制得的所述抗应激饲料添加剂易与饲料混合配比，也易被机体消化吸收。
本发明也提供了上述抗应激饲料添加剂的一种应用，是取所述抗应激饲料添加剂添加至基础日粮中，用于缓解鸡的应激反应。
作为本发明应用的一种限定，该应用是于应激状况(如接种疫苗、转群或断喙)发生前1-5天或产生应激当日起连续用5-10天。
作为本发明应用的另一种限定，应用过程中该抗应激饲料添加剂的添加量为基础日粮重量的0.05-0.15％。
作为本发明应用的第三种限定，应用过程中该抗应激饲料添加剂的添加量为基础日粮重量的0.1％。
由于采用了上述的技术方案，本发明与现有技术相比，所取得的技术进步在于：
(1)精氨酸(Arginine，Arg)是一种碱性氨基酸，是动物体合成蛋白质的必需氨基酸，是一氧化氮、尿素、鸟氨酸及肌丁胺的直接前体，是合成肌肉素的重要原素，此外，精氨酸可以通过调控机体内分泌途径调控机体生长，如精氨酸可以直接刺激机体分泌生长激素和胰岛素，也可以通过代谢生成鸟氨酸，而后生成谷氨酸，促进生长激素的释放，在机体发育不成熟、感染状态下，机体对精氨酸的需求量较大，补充适量的精氨酸可以有效促进蛋白质合成、增强组织修复、抑制炎症；动物应激状态下会导致诱导一氧化氮合成酶活化，合成大量一氧化氮，产生细胞毒性，同时 消耗大量精氨酸，造成营养缺乏症，此时补充精氨酸可调控精氨酸的代谢、维持精氨酸内源稳定性、调控内分泌、抑制炎症，从而缓解应激反应、降低损失；
(2)组氨酸(Histidine，His)是一种半必需氨基酸，也是一种碱性氨基酸，对其他营养物质的吸收代谢、肌肉发育具有一定作用，动物特别是幼龄动物因生长代谢旺盛，自身不能合成，对组氨酸营养需求量较大，如不及时补充，极易出现组氨酸缺乏，影响其生长；此外，组氨酸还能降低胃液酸度,抑制由植物神经紧张而引起的消化道溃烂，缓解应激反应；
(3)赖氨酸(Lysine，Lys)是一种碱性必需氨基酸，能够促进生长发育，帮助产生抗体、激素和酶，增强免疫功能，提高中枢神经组织功能；赖氨酸可以提高胃液分泌功能，增强食欲、促进氨基酸吸收，改善应激情况下，动物采食量下降、免疫力降低的情况；
(4)应激状况下，动物会出现采食量下降、爬卧不动，机体正常代谢失常，短时间内会消耗机体内的糖，产生乳酸；另一方面，应激状况下还能够引起炎症，导致酸中毒；本发明添加的精氨酸、赖氨酸、组氨酸均为碱性氨基酸，三种碱性氨基酸均能够被机体直接吸收，在血液和组织中可中和酸性物质，发挥化学缓冲作用，从而缓解应激反应；
(5)本发明参考文献数据，考虑精氨酸-赖氨酸的拮抗作用，经多次试验探索得到三种氨基酸的适宜配比，开发出能够协同促进动物生长发育、提高饲料利用率的抗应激饲料添加剂；
(6)本发明制备方法选用的过筛目数制备所得抗应激饲料添加剂，其粒度使其易与饲料混合，同时也易被机体消化吸收；
(7)本发明仅通过添加精氨酸、赖氨酸、组氨酸混合制备抗应激饲料添加剂，未添加价格较高且影响适口性的中草药和稳定性较差的维生素，制备方法简单、生产成本低廉，制得的抗应激饲料添加剂适口性、稳定性良好；
综上所述，本发明以精氨酸、赖氨酸、组氨酸三种碱性氨基酸为原料制备抗应激饲料添加剂，三种碱性氨基酸相互配合，协同缓解应激反应，、促进动物生长发育，、提高饲料利用率；本发明的制备方法简单、生产成本低廉，制得的抗应激饲料添加剂适口性、稳定性良好。
本发明适用于制备一种抗应激饲料添加剂，该抗应激饲料添加剂适用于鸡及其他禽类食用。
具体实施方式
以下具体实施例对本发明作进一步的阐述，但不作为对本发明的限定。
实施例1一种抗应激饲料添加剂的制备方法
本实施例为一种抗应激饲料添加剂的制备方法，分别称取精氨酸66.7kg、赖氨酸22.2kg、组氨酸11.1kg，混合均匀后，过65目筛，制得抗应激饲料添加剂，标记为M1。
实施例2-8抗应激饲料添加剂的制备方法
实施例2-8分别为一种抗应激饲料添加剂的制备方法，它们的制备步骤与实施例1基本相同，不同之处仅在于原料用量及工艺参数的不同，具体见下表：
表1实施例2-8中各项原料用量及工艺参数一览表
Figure PCTCN2020116379-appb-000001
实施例9抗应激饲料添加剂的应用效果实验
一)抗应激饲料添加剂应用于海兰褐产蛋鸡的效果实验
实施例1～8所提供的抗应激饲料添加剂M1-M8，分别添加至普通市售鸡饲料(产蛋鸡高峰期配合饲料)中，混合而成的鸡饲料一一对应标记为AM1-AM8，抗应激饲料添加剂M1-M8的添加量为普通市售鸡饲料(产蛋鸡高峰期配合饲料)重量的0.1％；将实施例1所提供的抗应激饲料添加剂M1，添加至普通市售鸡饲料(产蛋鸡高峰期配合饲料)中，M1的添加量分别为普通市售鸡饲料重量(产蛋鸡高峰期配合饲料)的0.05％、0.15％，混合而成的鸡饲料一一对应标记为AM9和AM10。
选择2750只196日龄海兰褐产蛋鸡，随机分成11组，每组250只，分别为对照组和实验组A1～A10组，其中对照组饲喂普通市售鸡饲料(产蛋鸡高峰期配合饲料)，A1～A10组分别饲喂AM1～AM10鸡饲料，全天饲喂不限量；本次试验的海兰褐产蛋鸡在同一栋鸡舍饲养，光照、饮水等饲养管理方式一致；本次试验的海兰褐产蛋鸡在199日龄时接种疫苗(新支流，胸部肌肉注射)，统计免疫前后的产蛋率，结果如表2：
表2免疫前后各组产蛋率
Figure PCTCN2020116379-appb-000002
由表2可知，A1～A10组中鸡的产蛋率不同程度的高于对照组，以A1组为佳，说明本发明的抗应激饲料添加剂有助于减轻注射疫苗对产蛋鸡的应激压力，稳定产蛋率。
二)抗应激饲料添加剂应用于AA肉鸡的效果实验
实施例1～8所提供的抗应激饲料添加剂M1-M8，分别添加至普通市售鸡饲料(肉雏鸡配合饲料)中，混合而成的鸡饲料一一对应标记为BM1-BM8，抗应激饲料添加剂M1-M8的添加量为普通市售鸡饲料(肉雏鸡配合饲料)重量的0.1％；将实施例1所提供的抗应激饲料添加剂M1，添加至普通市售鸡饲料(肉雏鸡配合饲料)中，M1的添加量分别为普通市售鸡饲料(肉雏鸡配合饲料)重量的0.05％、0.15％，混合而成的鸡饲料一一对应标记为BM9和BM10。
选择1100只5日龄AA肉鸡，随机分成11组，每组100只，分别为对照组和实验组B1～B10组，其中对照组饲喂普通市售鸡饲料(肉雏鸡配合饲料)，B1～B10组分别饲喂BM1～BM10鸡饲料，全天饲喂不限量；本次试验的AA肉鸡在同一栋鸡舍饲养，光照、饮水等饲养管理方式一致；本次试验的AA肉鸡在7日龄时肌肉注射免疫新流苗，统计免疫前后的体重，结果如表3：
表3免疫前后各组平均体重(g)
日龄 对照组 B1组 B2组 B3组 B4组 B5组 B6组 B7组 B8组 B9组 B10组
5 141 140 139 141 139 140 138 140 140 139 138
6 164 165 166 165 164 165 164 164 164 166 164
7(免疫) 194 192 194 193 193 193 193 194 192 193 193
8 218 226 220 222 222 221 220 218 220 225 224
9 243 259 246 248 248 250 254 253 250 256 258
10 273 296 287 285 287 286 287 283 289 294 295
11 319 334 323 329 330 329 329 329 330 333 332
12 360 374 369 368 370 370 369 370 371 372 372
13 403 419 407 409 417 414 413 415 416 417 416
14 452 463 460 458 458 455 456 459 460 462 461
15 492 512 510 509 507 508 498 499 502 510 511
16 547 563 551 550 558 559 560 561 560 559 560
17 605 614 611 608 604 604 609 608 611 611 613
由表3可知，B1～B10组中鸡的增重不同程度的高于对照组，以B1组为佳，说明本发明的抗应激饲料添加剂有助于减轻注射疫苗对肉雏鸡的应激压力，保持鸡体的正常生长发育，提高饲料转化率。
实施例10抗应激饲料添加剂的适口性实验
实施例1～8所提供的抗应激饲料添加剂M1-M8，分别添加至普通市售鸡饲料(雏鸡配合饲料)中，混合而成的鸡饲料一一对应标记为CM1-CM8，抗应激饲料添加剂M1-M8的添加量为普通市售鸡饲料(雏鸡配合饲料)重量的0.1％；将实施例1所提供的抗应激饲料添加剂M1，添加至普通市售鸡饲料(雏鸡配合饲料)中，M1的添加量分别为普通市售鸡饲料(雏鸡配合饲料)重量的0.05％、0.15％，混合而成的鸡饲料一一对应标记为CM9和CM10。
选择1100只5日龄AA肉鸡，随机分成11组，每组100只，分别为对照组和实验组BC1～BC10组，，其中对照组饲喂普通市售鸡饲料(雏鸡配合饲料，50Kg/袋(净含量))，B1～B10组分别饲喂SCM1～SCM10鸡饲料，各组鸡每日早8点添加5Kg料，次日投喂前将剩余料收集并称重，计算每日采食量，连续观察5日；本次试验的AA肉鸡在同一栋鸡舍饲养，光照、饮水等饲养管理方式一致；本次试验的AA肉鸡在7日龄时肌肉注射免疫新流苗，统计免疫前后的每日体重采食量，结果如表34：
表4各组鸡平均采食量(g)
日龄 对照组 C1组 C2组 C3组 C4组 C5组 C6组 C7组 C8组 C9组 C10组
5 35 36 35 35 36 36 36 35 35 35 36
6 38 38 38 37 38 38 38 37 37 37 38
7(免疫) 37 40 39 39 38 39 38 38 38 39 38
8 40 43 41 42 42 43 42 41 41 42 41
9 43 46 45 45 45 46 45 45 45 45 46
由表4可知，对照组和C1～C10组鸡在5-6日龄时采食量基本无明显差异，表明添加本发明的抗应激饲料添加剂不影响饲料的适口性；对照组在免疫当天采食量略有下降，这可能是注射应激造成，而C1～C10组鸡在免疫当天采食量无明显变化，说明本发明的抗应激饲料添加剂能有效缓解应激造成鸡群采食量下降的问题。
需要说明的是，以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照上述实施例对本发明进行了详细的说明，对于本领域技术人员来说，其依然可以对上述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (10)

  1. 一种抗应激饲料添加剂，其特征在于，制成它的有效成分的原料包括：精氨酸、赖氨酸、组氨酸。
  2. 根据权利要求1所述的一种抗应激饲料添加剂，其特征在于，以重量份数计，制成它的有效成分的原料包括：精氨酸50-70份、赖氨酸15-25份、组氨酸10-15份。
  3. 根据权利要求1或2所述的一种抗应激饲料添加剂，其特征在于，以重量份数计，制成它的有效成分的原料包括：精氨酸66.7份、赖氨酸22.2份、组氨酸11.1份。
  4. 权利要求1-3任意一项所述抗应激饲料添加剂的一种制备方法，其特征在于，取所有原料混合、过筛，即得所述抗应激饲料添加剂。
  5. 根据权利要求4所述一种抗应激饲料添加剂的制备方法，其特征在于，所述过筛的筛分粒度为65-100目。
  6. 权利要求1-3任意一项所述抗应激饲料添加剂的一种应用，其特征在于，所述抗应激饲料添加剂添加至基础日粮中，饲喂鸡以缓解应激反应。
  7. 根据权利要求6所述一种抗应激饲料添加剂的应用，其特征在于，所述抗应激饲料添加剂于应激状况发生前1-5天或产生应激当日起连续用5-10天。
  8. 根据权利要求6或7所述一种抗应激饲料添加剂的应用，其特征在于，所述抗应激饲料添加剂的添加量为基础日粮重量的0.05-0.15％。
  9. 根据权利要求6或7所述一种抗应激饲料添加剂的应用，其特征在于，所述抗应激饲料添加剂的添加量为基础日粮重量的0.1％。
  10. 根据权利要求8所述一种抗应激饲料添加剂的应用，其特征在于，所述抗应激饲料添加剂的添加量为基础日粮重量的0.1％。
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