WO2022029037A1 - Procédé pour la prévention de myopathies chez les volailles et compositions utiles à cet effet - Google Patents

Procédé pour la prévention de myopathies chez les volailles et compositions utiles à cet effet Download PDF

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Publication number
WO2022029037A1
WO2022029037A1 PCT/EP2021/071436 EP2021071436W WO2022029037A1 WO 2022029037 A1 WO2022029037 A1 WO 2022029037A1 EP 2021071436 W EP2021071436 W EP 2021071436W WO 2022029037 A1 WO2022029037 A1 WO 2022029037A1
Authority
WO
WIPO (PCT)
Prior art keywords
poultry
feed
vitamin
dihydroxy
myopathies
Prior art date
Application number
PCT/EP2021/071436
Other languages
English (en)
Inventor
Kathrin BÜHLER
Jan Dirk Van Der Klis
Ricardo LOSA
Original Assignee
Herbonis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Herbonis Ag filed Critical Herbonis Ag
Publication of WO2022029037A1 publication Critical patent/WO2022029037A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Definitions

  • the invention relates generally to poultry farming and its related constraints, in particular to methods and compositions suitable to obviate metabolic disorders affecting poultry muscle growth in such conditions, including feeds, feed or diet additives or compositions enabling the improvement of the quality of poultry meat subject to industrial processing.
  • Poultry farming is today one of the best ways to efficiently convert feed into high quality meat, i.e., with a beneficial protein/fat ratio.
  • the necessity to genetically improve yields as efficiently as possible, while shortening simultaneously the time spent to reach slaughter weight is leading to problems which, if not adequately solved, might affect seriously this type of farming due to impaired product quality.
  • Wooden breast is characterized by abnormal hardness and rigidity of the breast muscle, which can be in the form of a single focal lesion or in more severe cases throughout the whole muscle.
  • White striping is characterized by white striations parallel to the muscle fibers
  • Spaghetti meat is characterized by a loss of structural integrity of the breast muscle, leading to friability and loosening of the muscle fibers.
  • processing follows slaughtering and comprises detachment of the meat from the carcass, meat cutting, meat freezing, meat drying, meat storing or meat cooking.
  • Selection programs are focused to continuously improve the production traits of poultry or chicken and to develop high growth rates and breast-yield hybrids. These selection programs coincided with increased occurrence of said abnormalities. In view of this, several attempts have been made already to alleviate this problem focusing on nutrition and poultry growth rates, as selection programs were not able to reduce the incidence of said abnormalities yet.
  • a first object of the invention is a composition for use in a method for the prevention of myopathies in poultry which comprises as active ingredient 1,25- dihydroxy-vitamin D3-glycosides or any source of same, and more specifically a feed material or a feed component or a feed additive or a feed or diet or a water supplement comprising 1,25-dihydroxy-vitamin D3-glycosides or any source of same as active ingredient.
  • Another object of the invention is a poultry feed or diet for use in a method for preventing myopathies in poultry which comprises a composition as identified above.
  • Still another object of the invention is a method for preventing myopathies in poultry which comprises feeding the poultry by means of a poultry feed or diet as identified here above.
  • poultry covers most of the birds grown in farms and used for their meat, namely chicken, broilers, broiler breeders, ducks, turkeys, ostriches, geese, guinea fowl, quails.
  • Chicken or broilers, especially meat producing (fattening) poultry represents the category most frequently met within the frame of the invention.
  • myopathies is also not limitative as it concerns in particular myopathies affecting breast meat like Wooden breast, Spaghetti meat and White striping - see introduction here above.
  • abnormalities or “structural abnormalities” or “impaired meat structure” or “impaired breast meat structure” means structural defects of muscle tissue like those described here above.
  • high quality parts for human consumption means certain items of the carcass, which have a high economical value for the producer and are the preferred choice of the customer.
  • the high-quality parts of the carcass consist mainly but not exclusively of breast and leg meat. They are easy to cook and/or preferably used in convenience food.
  • feed or diet are deemed to cover any suitable feed or diet component or fed or diet supplement or feed or diet additive, or any suitable composition or ingredient in drinking water designed for use in poultry feed or diet.
  • the above feed or diet can be provided to the poultry over the entire growth period or, depending on specific conditions from day one to the day muscle growth rate has reached a plateau or also only during the first feeding phase.
  • the man skilled in the art benefits of a wide flexibility thanks to the information provided here below and can adjust the feed or diet composition to parameters such e.g., the type of poultry selected for farming, its genetics (natives or hybrids), environmental or climate factors, etc.
  • 1,25-dihydroxy-vitamin D3-glycosides defines a chemical entity wherein the term “glycosides” encompasses glucoside, fructoside, galactoside or any number of hexose and pentose units bound to the aglycon.
  • Sources of 1,25-dihydroxy-vitamin D3-glycosides comprise preparations made of or constituted by either the whole plant or any part of same, e.g., roots, leaves, and buds and obtained from but not limited to plants such as Solanum glaucophyllum, Cestrum diurnum, Trisetum flavescens and Nierembergia veitchii.
  • Solanum glaucophyllum plant material represents a preferred source of 1,25- dihydroxy-vitamin D3-glycosides. This plant material is provided either from wild or cultivated plants or hybrids of same like e.g., HERVIT® according to Plant Variety Certificate EU 25473.
  • any part of the plant defined here above preferably dried leaves of said plant.
  • 1,25-dihydroxy-vitamin D3-glycosides are provided to poultry, namely meat producing (fattening) poultry or broilers by means of their feed or diet containing the relevant active ingredient, in proportions able to achieve an average daily dose of about 0.1 pg to about 100 pg of 1,25- dihydroxy-vitamin D3-glycosides per kg poultry feed.
  • the said 1,25-dihydroxy-vitamin D3-glycosides can be incorporated to any feed dedicated to any state of development of the birds i.e., either as starter or grower or finisher poultry feed or diet or as a supplement to water or to water for drinking.
  • This incorporation is performed according to the techniques usually applied in this field for producing pellets or crumbles or mash or similar feed material, namely expansion, extrusion, coating, spraying, etc., to provide a solid feed or diet material - see examples below.
  • the said 1,25-dihydroxy-vitamin D3- glycosides can be conveniently provided to the poultry in the form of water or water for drinking supplement.
  • Panbonis® Plant based carrier(s) is intimately mixed with dried leaves of Solanum glaucophyllum and then processed until obtaining of a homogeneous powdered material.
  • the analytical content may vary according to the following range: 8 - 15 % (weight) of crude fibers, 14-30 % (weight) of starch and 0.001 - 0.006 % (weight) of 1,25-dihydroxy-vitamin D3-glycosides.
  • Panbonis® is a commercial product provided by Herbonis Animal Health GmbH - Rheinstrasse 30 - AUGST (Switzerland) and comprises of a defined amount of 1,25-dihydroxy-vitamin D3-glycosides.
  • a selected batch of dry leaves of Solanum glaucophyllum has been macerated under agitation at 40 - 60 °C for about 24 hours with the 5 to 12 liter per kg of a water/ethanol mixture.
  • the collected water / ethanol extracts were then combined and added with ascorbic acid in a ratio of 0.25 % by weight and pH of same was adjusted to 5 - 6.5 by means of a food-compatible acid, citric acid in this particular case.
  • the stabilized extract was then filtered and concentrated to approx. 30 to 50 % of dry matter content by means of vacuum drying technique and the resulting concentrated was poured onto a cationic exchanger resin equilibrated in its H + form.
  • the collected effluent was filtered and then subjected to UHT sterilization (125 °C for 1 min).
  • a specific amount of excipient preferable maltodextrin, lactose or corn starch, is added to the sterilized material in order to standardize the final content of active ingredients in the plant extract - 100 ppm of 1,25- dihydroxy-vitamin D3-glycosides.
  • Pre-trial 780 male Ross 308 broilers (2 treatments; 13 replicates; 30 broilers per replicate), during a 42 days growth cycle. Birds were fed a 3-phase diet (starter 0-13 days; grower 14-21 days; finisher 22-42 days).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Fodder In General (AREA)

Abstract

L'invention concerne un procédé pour la prévention de myopathies chez les volailles, comprenant l'alimentation des volailles au moyen d'une alimentation ou d'un régime qui comprend une substance d'alimentation, un composant d'alimentation ou un additif d'alimentation ou un supplément d'eau comprenant des 1,25-dihydroxy-vitamine D3-glycosides en tant que principe actif ou une quelconque source de ceux-ci. Le procédé est bien adapté à l'élevage des volailles et plus précisément à la prévention de myopathies de la poitrine chez les volailles d'engraissement et permet, par conséquent, une amélioration importante de la qualité de la viande de volaille, à savoir de ses propriétés sensorielles, texturales et nutritionnelles.
PCT/EP2021/071436 2020-08-06 2021-07-30 Procédé pour la prévention de myopathies chez les volailles et compositions utiles à cet effet WO2022029037A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20189739.4 2020-08-06
EP20189739 2020-08-06

Publications (1)

Publication Number Publication Date
WO2022029037A1 true WO2022029037A1 (fr) 2022-02-10

Family

ID=71994311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2021/071436 WO2022029037A1 (fr) 2020-08-06 2021-07-30 Procédé pour la prévention de myopathies chez les volailles et compositions utiles à cet effet

Country Status (1)

Country Link
WO (1) WO2022029037A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009129818A1 (fr) * 2008-04-21 2009-10-29 Herbonis Ag Préparation et utilisation d'un extrait végétal de solanum glaucophyllum possédant une teneur enrichie en glycosides de 1,25-dihydroxyvitamine d<sb>3</sb> et glycosides de quercétine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009129818A1 (fr) * 2008-04-21 2009-10-29 Herbonis Ag Préparation et utilisation d'un extrait végétal de solanum glaucophyllum possédant une teneur enrichie en glycosides de 1,25-dihydroxyvitamine d<sb>3</sb> et glycosides de quercétine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GILI VALERIA ET AL: "In vitroeffects of 1[alpha],25(OH)2D3-glycosides from Solbone A (Solanum glaucophyllumleaves extract; Herbonis AG) compared to synthetic 1[alpha],25(OH)2D3on myogenesis", STEROIDS, vol. 109, 2016, pages 7 - 15, XP029498495, ISSN: 0039-128X, DOI: 10.1016/J.STEROIDS.2016.03.002 *
LON-WO ESMERALDA ET AL: "Evaluation of Cestrum diurnum as an alternative of vitamin D-3 in broiler feeding", CUBAN JOURNAL OF AGRICULTURAL SCIENCE, INSTITUTO DE CIENCIA ANIMAL, CU, vol. 29, no. 3, 1 January 1995 (1995-01-01), pages 349 - 354, XP009080332, ISSN: 0864-0408 *
MATHIS G ET AL: "Safety profile of 1,25-dihydroxyvitamin D3 of herbal origin in broiler chicken", SCHWEIZER ARCHIV FUER TIERHEILKUNDE., vol. 158, no. 12, 5 December 2016 (2016-12-05), CH, pages 819 - 826, XP055795941, ISSN: 0036-7281, Retrieved from the Internet <URL:https://sat.gstsvs.ch/fileadmin/datapool_upload/IgJournal/Artikel/pdf/SAT_12_2016_Mathis.pdf> DOI: 10.17236/sat00097 *
V. GILI ET AL., STEROIDS, vol. 109, 2016

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