WO2022015275A1

WO2022015275A1 - Herbal composition that provides protection against viruses and has medicinal and pharmacological properties

Info

Publication number: WO2022015275A1
Application number: PCT/TR2021/050735
Authority: WO
Inventors: Belkıs YAŞA
Original assignee: Bursa Tekni̇k Üni̇versi̇tesi̇ Rektörlüğü
Priority date: 2020-07-17
Filing date: 2021-07-16
Publication date: 2022-01-20
Also published as: TR202011358A2

Abstract

The invention particularly relates to the herbal composition containing Artemisia annua extract and the powder of Artemisia annua herb and the production method of the mentioned herbal composition, which provides the immune system modulation to normalize again, while providing an antiviral effect, thus enabling the treatment of the disease and the prevention of its contagiousness.

Description

Herbal composition that provides protection against viruses and has medicinal and pharmacological properties

Technical Field

The invention is related to medicinal pharmacological herbal composition for pandemic diseases and respiratory viral infections caused by SARS, MERS-COV, SARS-COV-2, influenza etc.

Prior Art

Viral infection is a general name for diseases caused by various strains of viruses. Viruses can cause contagious diseases such as common cold, influenza, flu or wart besides serious diseases such as HIV and AIDS, smallpox or hemorrhagic fever.

Viruses may infect a suitable host cell or cells and replicate themselves within the cell for the replication of their DNA or RNA and protein can. Once they have infected the host cell, they control the cell and use it to replicate their genetic material namely their DNA or RNA. The replicated DNA or RNA as well as protein are then assembled into virus particles.

After the virus has used the host cell for its ends, the cell bursts other nearby cells can be infected with the new viruses. Some viruses change the cell functions after infection, instead of causing it to burst. Some viruses cause the cell to lose its control on normal cell division, which lead it to divide uncontrollably and to become cancerous.

Sometimes certain viruses leave just their genetic material in the host cell, which remains dormant within the cell (Latent infection). When the immune system weakens, the replication process of the genetic material begins and certain diseases can afflict the person.

Depending on the strain, viruses tend to infect certain types of cells for example, the virus causing common cold infect the cells in the upper respiratory tract. They may also distinguish between humans and certain types of animals, plants when they infect the cell. In some cases, it may be difficult to determine if a disease is due to viral or bacterial causes, because certain diseases such as pneumonia, meningitis or diarrhea can be caused either by viruses or bacteria. The most important difference which lies in the viral and bacterial diseases is the treatment of bacterial diseases with antibiotics. Here one should note that antibiotics don’t have any effect on viruses. It may be difficult to treat any viral diseases because viruses are alive mostly inside the cell and more inside the circulatory system.

Only a few medications are known to be effective for the treatment of viral diseases. Also there are some vaccines that protect against certain kinds of the viruses.

One of the virus types causing social problems is corona virus that most people encounter in their daily lives. They generally cause mild to moderate infections in the upper respiratory tract. There are four known genome for coronavirus: alpha, beta, gamma and delta coronavirus. Middle East respiratory syndrome (MERS-COV), severe acute respiratory syndrome (SARS-COV) and common cold are some of the diseases that coronavirus (COV) causes.

The subtypes of coronavirus found in humans such as HCOV-229E, HCOV-OC43, HCOV- NC63 and HKU1-COV mostly cause common cold. SARS-COV was first identified in 2003 as the public health emergency of international concern and led Hundreds of people to die. After almost 10 years MERS-COV infection of humans was first detected in Saudi Arabia in September 2002. But it later turned out that the first cases of infection were actually reported at a hospital in Zarqa Jordan in April 2012. Because of unsettling experiences with SARS, public fears arose. In December 2019, pneumonia cases were reported by WHO. In January 2020 it was found to be a new coronavirus (2019-NCOV), which was not seen in humans until then.

The name was later changed from 2019-NCOV to COVID-19/SARS-COV. This type of virus infects people with upper respiratory diseases of mild to moderate severity. The symptoms of COVID-19 infections are low-grade fever, dry cough, labored breathing and respiratory symptoms. In severe cases the virus can lead to pneumonia, severe acute respiratory infection, kidney failure and maybe death. Nevertheless, based on available data no definitive comment about the severity of the infection can be made.

Currently there is no specific treatment method for the COVID-19 infection. Generally the symptoms disappear without any intervention. Specialist doctors try to alleviate symptoms by prescribing painkillers and antifebriles. Improving indoor humidity conditions and taking a warm shower are helpful to reduce cough and relieve a sore throat. Drinking plenty of fluids, taking a rest and getting enough sleep are beneficial for the treatment of the infection. When the symptoms worsen and become more severe than those of the common cold, then other treatment methods are applied under the supervision of the specialist doctor. The research on effective vaccines, medications and treatment methods for COVID-19 infection is still going on.

Some applications have been encountered related to compositions developed for use in the treatment of COVID-19 infection in the prior art. One of these is the patent application numbered TR 2020 04066. This application is about antiviral medicinal herbal composition made up of olive oil, clove oil and black cumin oil which is also used for disease of the gingiva and the peptic ulcer when taken orally.

The patent application numbered TR 2020 05519, there is an anise roots cure that protects human health because it inhibits the replication of coronavirus in the viral and bacterial infection of upper respiratory tract. This cure mainly consists of volatile fatty acids cyclopentenyl and anise root. In the patent application, there is also an explanation of how to use this cure.

Artemisia annua, which has another name in the colloquial language, is instrumental in reducing fever and has a strengthening and gastroprotective effect. Due to the substance artemisinin it is important for medicinal use and treatment of certain diseases and infections. There are some research on its regulatory effect on the production of immune medicators, besides its antiviral effects. One in vitro reported that Artemisia annua has the most antiviral and antiherpetic effect among other homogenized methanolic artemisia extracts (1). Similarly pure artemisinin was proved to be effective at fighting against bovine viral diarrhea virus from family of flaviviridae treated with artemisinin which was found to have an inhibiting effect on the infectious agent (2). In another study conducted in 2005, which showed the antiviral effect of the Artemisia annua, effective substances with antiviral activities against Hepatitis B virus were divided into 4 groups, it was reported that artemisinin is the most powerful substance in terms of acting as viral inhibitors. It has reduced Hepatitis B surface antigen depending on the optimum dose designed not to damage the host cells (3). The studies that examine whether Artemisia annua can be used in the treatment for contagious viral infections are still going on. Yet, there is no study examining whether it can be used in the treatment for contagious viral infections caused by influenza, SARS, MERS-COV, SARS- COV-2 and for the diseases affecting immune system. As a result, due to the aforementioned negativities and deficiencies, there has been a need to make an innovation in the relevant technical field.

The Aim of the Invention

The present invention relates to a herbal composition that provides protection against viruses and has medicinal and pharmacological properties that meets the aforementioned requirements, eliminates the all disadvantages and brings some additional advantages.

The aim of the invention is to present a completely herbal composition for use in infectious viral infections and diseases affecting the immune system caused by influenza, SARS, MERS-CoV, SARS-CoV-2 viruses.

The aim of the invention is to present a composition that does not adversely affect human health, improves the bad course of the disease, thanks to its herbal content, and reduces the side effects of the drugs given and the infectious potential of the disease.

The aim of the invention is to demonstrate the utility of Artemisia annua in the medical treatment of COVID-19 infection caused by SARS-CoV-2 viruses.

The aim of the invention is to accelerate the recovery with existing treatments, thanks to the positive synergistic effect of the phytochemicals in Artemisia annua in viral diseases.

The aim of the invention is to increase the awareness and use of Artemisia annua for effective and less toxic medicine.

The aim of the invention is to ensure the effective use of our national resources in the health industry during and after the pandemic.

In order to reach the aims mentioned above, this invention is an antiviral composition with medicinal and pharmacological properties, which protects against viral and pandemic diseases that threaten human health, like respiratory infections of influenza, SARS, MERS- COV, SARS-COV-2 etc. this composition produced with the intention of fulfilling the abovementioned goals contains Artemisia-annua extract and the powder of Artemisia annua herb, which bring the immune system modulation back to normal, while also having an antiviral effect. The herbal composition production method in order to fulfill the aims of the invention comprising the following process steps,

• In order to obtain Artemisia annua extract, 80-96% (volume) ethyl alcohol by volume is added to the above-ground part of Artemisia annua at a ratio of 1:2 to 1:5 and kept at 20-25 °C for at least 24 hours, at most 96 hours and then applying filtration, filtration, evaporation processes,

• To obtain the Artemisia-annua powder, the leaves and flowers of this herb are pulverized into powder,

• Mixing the obtained Artemisia annua extract and the powder of Artemisia annua herb.

The structural and characteristic features and all of the advantages of the invention will be understood more clearly by means of the detailed description given below and therefore evaluation should be made by taking this detailed description into consideration.

Detailed Description of the Invention

In this detailed description, a herbal composition that provides protection against viruses and has medicinal and pharmacological properties is described only for a better understanding of the subject and without any limiting effect.

The invention is related to medicinal pharmacological herbal composition for pandemic diseases and respiratory viral infections caused by SARS, MERS-COV, SARS-COV-2, influenza etc. The feature of the invention is that it contains Artemisia annua extract and the powder of Artemisia annua herb, which provides antiviral effect and normalizes the modulation of the immune system, thus making it possible to treat the disease and prevent its contagiousness.

The inventive formulation of the herbal composition ;

Artemisia annua extract contains compounds that provide antiviral effects and optimize immune system modulation. As Artemisia annua extract, this rich content can be obtained more intensely. Phytochemicals and volatile substances in the Artemisia annua extract, which undergo a change due to the processes applied can be preserved in the original proportions of the herbal composition and in the natural structure of the herb. The compounds preserved in the powder of the herb contribute to this invention.

The positive synergetic effect of the phytochemicals in Artemisia annua together with the existing treatment methods for the viral infections accelerates the recovery process of patients. Artemisia annua is antiviral, antimicrobial and activates several pathways in the immune system. All these make a synergetic effect possible due to the special combination of such volatile terpen and terpenoid compounds in Artemisia annua as Camphene, Artemisia ketone, Linalool, Artemisia alcohol, 1,8 Cineole as well as sesquiterpene lactone, flavonoids, coumarin groups.

The production method of the herbal composition subject to the invention is as follows;

Artemisia annua extract is obtained by extracting the aboveground part of Artemisia annua in the ethyl alcohol 80-96% (volume) ethyl alcohol is added to this part of the herb with a proportion of 1:2 to 1:5, which is then left to rest for min. 24, max. 96 hours at a temperature of 20-25 °C during this time, it should be shaken at regular intervals. After 96 hours of resting, it is filtered and evaporated in succession. At the end of these processes Artemisia annua extract is obtained. To have Artemisia annua powder, the leaves and flowers of Artemisia annua herb are brought into a powder form. At the end the extract and powder forms are mixed.

The herbal composition produced through the abovementioned method is in solid form and should be used orally, one to three times a day in the treatment of affecting immune system and of contagious viral infections caused by influenza, SARS, MERS-COV, SARS-COV-2.

REFERENCES Karamoddini MK, Emami SA, Ghannad MS, Sani EA, Sahebkar A. Antiviral activities of aerial subsets of Artemisia species against Herpes simplex virus Type 1 (HSV1) in vitro. Asian Biomedicine 2011 , 5:63. Romero RM, Serrano MA, Vallejo M, Efferth T, Alvarez M, Marin JJG. Antiviral Effect of Artemisinin from Artemisia annua against a Model Member of the Flaviviridae Family, the Bovine Viral Diarrhoea Virus (BVDV). Planta Medica 2006, 72(13) 1169-1174. Romero RM, Efferth T, Serrano MA, Castano B, Macias RIR, Briz O, Marin JJG. Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an “in vitro” replicative system. Antiviral Research 2005, 68:75-83.

Claims

1. This invention is an antiviral composition with medicinal and pharmacological properties, which protects against viral and pandemic diseases that threaten human health, like respiratory infections of influenza, SARS, MERS-COV, SARS-COV-2 etc. this composition produced with the intention of fulfilling the abovementioned goals contains Artemisia-annua extract and the powder of Artemisia annua herb, which bring the immune system modulation back to normal, while also having an antiviral effect thus curing the disease and preventing infections.

2. A herbal composition according to claim 1, characterized in that it comprises 50-90% by weight Artemisia annua extract, 10-%50 by weight Artemisia annua herbal powder.

3. A production method for herbal composition suitable for any of preceding claims characterized in that comprising steps of;

4. A herbal composition obtained with a method according to claim 3, characterized in that; is in solid form.

5. A herbal composition obtained with a method according to claim 3, characterized in that; used orally one to three times a day for the treatment of infectious viral diseases such as influenza, SARS, MERS-COV, SARS-COV-2 diseases affecting the immune system.