WO2021251925A1 - Herbal supplement cream used in cancer patients - Google Patents

Herbal supplement cream used in cancer patients Download PDF

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Publication number
WO2021251925A1
WO2021251925A1 PCT/TR2021/050348 TR2021050348W WO2021251925A1 WO 2021251925 A1 WO2021251925 A1 WO 2021251925A1 TR 2021050348 W TR2021050348 W TR 2021050348W WO 2021251925 A1 WO2021251925 A1 WO 2021251925A1
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WO
WIPO (PCT)
Prior art keywords
cream
cancer patients
relates
herbal supplement
oil
Prior art date
Application number
PCT/TR2021/050348
Other languages
French (fr)
Inventor
Enes Emre AKMAN
Original Assignee
CABIOĞLU, Neslihan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CABIOĞLU, Neslihan filed Critical CABIOĞLU, Neslihan
Publication of WO2021251925A1 publication Critical patent/WO2021251925A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

  • This invention relates to an herbal supplement cream that is used in cancer patients, and wherein the required ingredients and their weight ratios are as follows:

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to an herbal supplement cream that has treatment-related supplementary skin care and wound healing properties in cancer patients, and it is used in cancer patients with its content of bitter squash extract, oil, vaseline, Stearic acid, alcohol, Isopropyl Myristate, glycerine and water.

Description

HERBAL SUPPLEMENT CREAM USED IN CANCER PATIENTS
Technical Field
This invention relates to an herbal supplement cream that is used in cancer patients for the purpose of assisting skin care and supporting the wound healing and the reduction of inflammation.
Background of the Invention
Cancer patients experience many problems due to the adverse effects of cancer treatment along with the process of disease. Cancer treatments can affect the physical appearance. For example, loss of hair and eyebrow, changes in nail and skin and facial swelling are among the adverse effects of the treatments. Cancer treatments such as chemotherapy may dry the skin much and leave an adverse effect on the skin. Some adverse effects may develop in the skin tissue in the region where radiotherapy treatment is applied. These adverse effects start with mild rashes such as sunburn and may go up to wet, open wounds.
Cancer patients have high level of need for help in coping with the disease and treatment. Cancer patients need professional care aimed at contributing to the quality of life. This care primarily provides maximum symptom control and minimizes the physical and emotional suffering of the patients.
In the current situation, patients use skin care products for their skins that exhibit change. During this period, patients use products such as skin care products, cleansers and moisturisers, etc. These products are Neutrogena Soothing Clear Moisturiser, Nature's Secrets Golden Turmeric Facial Cream, Flametan, Flametol, Bepanthen plus, Madecassol. The invention is a skin care and anti-inflammatory cream as a supplement to treatment in cancer patients. It heals wounds resulting from skin problems such as skin redness and irritation in cancer patients who are undergoing radiotherapy treatment. It has a supportive effect on the healing of wounds and rashes on the breast skin in patients with breast cancer.
The structural and characteristic features and all advantages of the invention will be understood more clearly through the detailed statement written below. For this reason, the evaluation should be performed by considering the detailed statements written below.
Detailed Description of the Invention
In this detailed statement, the present invention is explained in a way that the herbal supplement cream that can be used in cancer patients during cancer treatments does not have any limiting effect.
This invention relates to an herbal supplement cream that is used in cancer patients, and wherein the required ingredients and their weight ratios are as follows:
• 5-50% of Bitter squash extract,
• 1-30% of Turmeric oil,
• 1-10% of Olelim nigellae sativae (Black cumin oil),
• 0.1 -0.5% of Black pepper oil,
• 2-10% of Vaseline,
• 1-5% of PEG100 (Polyethylene Glycol Stearate), Glyceryl stearate
• 1 -7% of Stearic acid,
• 1 -7% of Cetyl alcohol,
• 1-5% of Paraffin oil, • 1 -5% of Isopropyl Myristate,
• 1 -7% of Shea Butter,
• 1-5% of Coconut oil,
• 1-10% of Glycerine,
• 0.01 -0.5% of Benzyl Alcohol,
• 0.5-2% of Phenoxyethanol,
• 0.01-1% of TriEthanolAmine,
• 30-70% of Water,
• Or 0.1-1% of colouring agent,
• Or 0.1-1% of odorizer.
The process steps of herbal supplement cream used in cancer patients are as follows:
• Collecting the bitter squash fruit before it is ripe, separating it from its pulp with an industrial type of fruit press and obtaining the bitter squash extract by filtering the juice of the fruit,
• Oils; obtaining the oils in the formulation by cold pressing, infusion method with water vapour distillation or maceration method,
• Melting and mixing substances in oil phase in a container (beaker) within a water bath at 50-80Q C,
• Mixing substances in water phase in a separate container (beaker) within a water bath at 50-80Q C,
• Keeping the substances in both containers (beakers) within a water bath at 50-80Q C for 10-45 minutes against possible microbial effects,
• Removing the substances from both containers (beakers) and by keeping them at room temperature, reaching the range of 50-75Q C in a cold room or within cold water bath,
• Transferring the beaker with water phase to the container (beaker) that contains the oil phase, among two phases reached to the appropriate temperature, and decanting it,
• Obtaining a fixed form by mixing the combined phases with a suitable mixer until the cream form is formed,
• Adding preservatives and/or colouring and odoring agents during mixing within the range of 30-50Q C,
• Resting for approximately 10 minutes after obtaining the fixed form.
With the Turmeric Oil in the invention, the skin problems caused by the Anti-cancer effect as a result of radiation therapy are eliminated. Olelim nigellae sativae heals wounds and performs skin care. The effect of black pepper oil improves by exhibiting combined effect with turmeric oil. Vaseline increases the absorption time on the skin barrier. PEG100 Stearate and Glyceryl Stearate act as a stabilizer for the Oil/water emulsion. Stearic acid is Co-emulsifier solvent and Cetyl alcohol is Emulsifier solvent. Paraffin oil and coconut oil facilitate skin care by increasing the absorption time. The content of Isopropyl Myristate exhibits softening and lubricating characteristics. Shea butter is moisturising and contains essential minerals for skin care. Glycerin has moisturising characteristics and Benzyl alcohol, Phenoxyethanol have protective characteristics. TriEthanolAmine Surfactant stabilizes the surface tension.
It is obvious that a person skilled in the art can demonstrate the novelty revealed in the invention by using similar embodiments and/or can apply this embodiment in other areas of similar purpose used in the art. It is therefore obvious that such embodiments will not accommodate the criterion of overcoming novelty and in particular the known status of art.

Claims

1. The invention relates to a herbal supplement cream used in cancer patients, and characterized in that it contains the following ratios;
• 5-50% of Bitter squash extract,
• 1-30% of Turmeric oil,
• 1 -10% of Olelim nigellae sativae
• 0.1 -0.5% of Black pepper oil, · 2-10% of Vaseline,
• 1-5% of PEG100 (Polyethylene Glycol Stearate), Glyceryl stearate
• 1 -7% of Stearic acid,
• 1 -7% of Cetyl alcohol,
• 1-5% of Paraffin oil, · 1-5% of Isopropyl Myristate,
• 1 -7% of Shea Butter,
• 1-5% of Coconut oil,
• 1-10% of Glycerine,
• 0.01 -0.5% of Benzyl alcohol, · 0.5-2% of Phenoxyethanol,
• 0.01-1% of TriEthanolAmine,
• 30-70% of Water.
2. According to Claim 1 , the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains turmeric oil that eliminates the skin problems with its Anti-cancer effect as a result of radiation therapy.
3. According to Claim 1 , the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains olelim nigellae sativae that heals the wounds and performs skin care.
4. According to Claim 1 or 2, the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains blackpepper oil that improves its effect in combination with turmeric oil.
5. According to Claim 1 , the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains Vaseline, Paraffin oil and coconut oil having an effect to increase the absorption time on the skin barrier.
6. According to Claim 1 , the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains PEG100 Stearate and Glyceryl Stearate acting as a stabilizer for the Oil/water emulsion.
7. According to Claim 1 , the invention relates to a herbal supplement cream that is used in cancer patients, and characterized in that it contains Stearic acid as Co-emulsifier solvent and Cetyl alcohol as Emulsifier solvent.
8. According to Claim 1 , the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains Isopropyl Myristate exhibiting softening and lubricating characteristics.
9. According to Claim 1 , the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains moisturiser Shea butter and glycerine that are essential minerals for skin care.
10. According to Claim 1 , the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains Benzyl alcohol, Phenoxyethanol that have protective characteristics.
11. According to Claim 1 , the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains TriEthanolAmine Surfactant stabilizing the surface tension.
12. According to Claim 1, the invention relates to an herbal supplement cream that is used in cancer patients, and characterized in that it contains 0.1-1% of colouring agent or 0.1-1% of odorizer as an option.
13. The invention relates to a herbal supplement cream used in cancer patients, and characterized in;
• Collecting the bitter squash fruit before it is ripe, separating it from its pulp with an industrial type of fruit press and obtaining the bitter squash extract by filtering the juice of the fruit,
• Oils; obtaining the oils in the formulation by cold pressing, infusion method with water vapour distillation or maceration method,
• Melting and mixing substances in oil phase in a container (beaker) within a water bath at 50-80Q C,
• Mixing substances in water phase in a separate container (beaker) within a water bath at 50-80Q C
• Keeping the substances in both containers (beakers) within a water bath at 50- 80Q C for 10-45 minutes against possible microbial effects,
• Removing the substances from both containers (beakers) and by keeping them at room temperature, reaching the range of 50-75Q C in a cold room or within cold water bath,
• Transferring the beaker with water phase to the container (beaker) that contains the oil phase, among two phases reached to the appropriate temperature, and decanting it,
• Obtaining a fixed form by mixing the combined phases with a suitable mixer until the cream form is formed,
• Adding preservatives and/or colouring and odoring agents during mixing within the range of 30-50Q C,
• Resting for approximately 10 minutes after obtaining the fixed form.
PCT/TR2021/050348 2020-06-12 2021-04-13 Herbal supplement cream used in cancer patients WO2021251925A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2020/09159A TR202009159A2 (en) 2020-06-12 2020-06-12 HERBAL REINFORCED CREAM USED IN CANCER PATIENTS
TR2020/09159 2020-06-12

Publications (1)

Publication Number Publication Date
WO2021251925A1 true WO2021251925A1 (en) 2021-12-16

Family

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Application Number Title Priority Date Filing Date
PCT/TR2021/050348 WO2021251925A1 (en) 2020-06-12 2021-04-13 Herbal supplement cream used in cancer patients

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TR (1) TR202009159A2 (en)
WO (1) WO2021251925A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1205202A (en) * 1997-07-16 1999-01-20 安仁县中医院 Face beauty powder made of natural plants
IN2013MU01940A (en) * 2013-06-04 2015-05-29 C Badwaik Gopesh

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1205202A (en) * 1997-07-16 1999-01-20 安仁县中医院 Face beauty powder made of natural plants
IN2013MU01940A (en) * 2013-06-04 2015-05-29 C Badwaik Gopesh

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
INDRAWATI TETI, HAJARD ISMAYANTI, PRATAMI DIAH KARTIKA: "SKINCARE CREAM PREPARATION AND EVALUATION OF PARE (MOMORDICA CHARANTIA) LEAVES USING THREE DIFFERENCE BASE", INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICS, vol. 12, no. 6, 1 January 2020 (2020-01-01), pages 162 - 166, XP055885892, DOI: 10.22159/ijap.2020v12i6.37921 *

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