WO2021249544A1 - 超声波振动装置和液体混合系统 - Google Patents

超声波振动装置和液体混合系统 Download PDF

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Publication number
WO2021249544A1
WO2021249544A1 PCT/CN2021/099735 CN2021099735W WO2021249544A1 WO 2021249544 A1 WO2021249544 A1 WO 2021249544A1 CN 2021099735 W CN2021099735 W CN 2021099735W WO 2021249544 A1 WO2021249544 A1 WO 2021249544A1
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WIPO (PCT)
Prior art keywords
groove
diameter
mixing tank
hole
liquid
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PCT/CN2021/099735
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English (en)
French (fr)
Inventor
陈思
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杭州准芯生物技术有限公司
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Publication of WO2021249544A1 publication Critical patent/WO2021249544A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F2035/98—Cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F2035/99—Heating

Definitions

  • This application relates to liquid detection, in particular to ultrasonic vibration devices and liquid mixing systems.
  • samples and multiple reagents need to be added to the mixing chamber, such as a test tube.
  • These samples can be human and animal samples, such as whole blood, plasma, serum, urine, saliva, feces, cerebrospinal fluid or lavage fluid, wax-sealed tissues and sections, tissue homogenates, and can also be plants, including traditional Chinese medicine, food Raw materials, processed foods, meats, beverages and alcoholic beverages, and raw materials and semi-finished products obtained in the beverage manufacturing process. It can also be cell culture or virus culture.
  • the types of components analyzed include minerals, inorganic substances, organic substances, nucleic acid DNA, RNA, protein or fat. At present, the following methods are mainly used for liquid mixing:
  • the mixing tank cannot be fixed, needs to be moved around, cannot realize integrated operation, and the work efficiency is low; the mechanical oscillation platform is large in volume; the mixing effect is poor.
  • the volume of the mixing tank is small, the rotating space of the stirrer is limited, the mixing effect is poor, and the device is large in volume.
  • the present application provides an ultrasonic vibration device with a simple structure and a small volume.
  • the ultrasonic vibrating piece and the vibrating rod; the ultrasonic vibrating device further includes:
  • a housing the housing has a hollow inside, one end has a through hole, and the other end is fixed with a fixing member; the diameter of the through hole is smaller than the diameter of the hollow part; the vibrating rod passes through the hollow part and the through hole and extends to Outside the shell
  • a first extension part, the middle part of the vibrating rod has an outward first extension part; the diameter of the hollow part is not less than the diameter of the first extension part;
  • a second extension part the outer edge of the first extension part has a second extension part extending in a direction parallel to the axial direction of the vibrating rod, and the vibrating rod, the first extension part and the second extension part are enclosed in a ring shape Groove; the outer diameter of the second extension is greater than the diameter of the through hole, not greater than the diameter of the hollow portion;
  • the elastic body is located between the fixing member and the vibrating rod.
  • the purpose of this application is also to provide a liquid mixing system using the above-mentioned ultrasonic vibration device, which is achieved through the following technical solutions:
  • a liquid mixing system includes a mixing tank and a stirrer; the liquid mixing system further includes:
  • the vibration unit adopts the above-mentioned ultrasonic vibration device and is arranged on the lower side of the mixing tank; the end of the vibration rod abuts against the bottom end of the mixing tank.
  • the liquid mixing system of the present application has a simple structure and a small volume; the ultrasonic vibration technology is used to realize the vibration mixing of the liquid in the mixing tank.
  • the ultrasonic vibration device has a simple structure, small occupation volume, fixed installation of the mixing tank and no need to move; the mixing effect is good; the use of small amplitude Ultrasonic vibration, combined with the agitator in the mixing tank, achieves the purpose of uniform mixing and high efficiency; the design of the inner diameter of the mixing tank with the upper width and the lower narrow reduced to further improve the mixing effect; the design of the extension part, the first part and the second part,
  • the vibration effect is further improved, that is, the liquid mixing effect is improved; multi-function; the temperature control unit realizes the heating and cooling of the liquid in the mixing tank, with small volume and good temperature control effect; the shape of the temperature control unit and the mixing tank are matched to further improve The effect of temperature control.
  • FIG. 1 is a schematic diagram of the structure of the ultrasonic vibration device of this application.
  • Fig. 1 schematically shows a basic structure diagram of an ultrasonic vibration device according to an embodiment of the present application.
  • the ultrasonic vibration device includes:
  • Ultrasonic oscillating plate 11, vibrating rod 21-22; ultrasonic oscillating plate and vibrating rod are existing technologies in this field, and the specific structure and working mode are not repeated here;
  • the housing 31 has a hollow interior, one end has a through hole 33, and the other end has a fixing member 51.
  • the fixing member 51 is fixed to the housing 31 by bolts or the like; the diameter of the through hole 33 is smaller than that of the hollow portion 32 Diameter; the vibrating rod 21-22 passes through the hollow portion 32 and the through hole 33, and extends to the outside of the housing 31;
  • the first extension 41, the middle of the vibrating rod has an outward first extension 41; the diameter of the hollow portion 32 is not less than the diameter of the first extension 41, so that the first extension 41 is in the housing Within 31;
  • the second extension 42 the outer edge of the first extension 41 has a second extension 42 extending parallel to the axial direction of the vibrating rod, the vibrating rod 21-22, the first extension 41 and the second extension 42
  • the extension portion 42 encloses an annular groove; the outer diameter of the second extension portion 42 is greater than the diameter of the through hole 33 and not greater than the diameter of the hollow portion 32, so that the second extension portion 42 is restricted to the housing Within 31, the through hole 33 cannot be passed through;
  • the elastic body 61 is located between the fixing member 51 and the vibrating rod 21.
  • the first extension portion extends along the radial direction of the vibrating rod.
  • the vibrating rod includes:
  • the first part 21 is arranged along the direction from the fixing member 51 to the elastic body 61, the first part 21 and the second part 22 are arranged in sequence, and the diameter of the first part 21 is larger than the second part 22;
  • the second part 22, the second part 22 extends to the outside of the housing 31, and the end shape matches the object to be vibrated.
  • the shape of the end portion is a concave curved surface.
  • one end of the vibrating rod and/or the fixing member has a groove, and one end of the elastic body is in the groove.
  • the liquid mixing system includes:
  • the mixing tank is made of plastic material, from top to bottom, the inner diameter of the mixing tank gradually becomes smaller, and the outer wall of the bottom end is a convex curved surface;
  • the stir bar uses magnetic beads;
  • a temperature control unit adopts a metal material and is sleeved outside the mixing tank in a ring shape, the inner wall matches the outer wall (convex curved surface) of the mixing tank, and an electric heating body is arranged in the temperature control unit ;
  • the bottom end of the mixing tank extends to the lower side of the temperature control unit; the cold end of the TEC refrigerator is attached to the temperature control unit, and the hot end is attached to the radiator; the airflow generated by the fan sweeps the radiator;
  • Ultrasonic vibration device including:
  • the ultrasonic oscillating sheet 11, the ultrasonic oscillating sheet 11 is an existing technology in the field, and the specific structure and working mode are not repeated here;
  • a vibrating rod, the vibrating rod includes:
  • the second part 22, the second part 22 extends to the outside of the housing 31, and the end is a concave curved surface, which matches the shape of the bottom end of the mixing tank, so that the end of the second part 22 firmly resists the mixing The bottom of the pool is not loose;
  • the housing 31 has a hollow interior, one end has a through hole 33, and the other end has a fixing member 51; the diameter of the through hole 33 is smaller than the diameter of the hollow portion 32; the vibrating rod 22 passes through the hollow portion 32 and the through hole 33, extending to the outside of the housing 31;
  • the first extension 41, the middle part of the vibrating rod 21 has a first extension 41 outward along the radial direction of the vibrating rod; the diameter of the hollow part 32 is not less than the diameter of the first extension 41, so that The first extension 41 is in the housing 31;
  • the second extension 42, the outer edge of the first extension 41 has a second extension 42 extending parallel to the axial direction of the vibrating rod 21, the vibrating rod 21, the first extension 41 and the second extension
  • the outer diameter of the second extension portion 42 is greater than the diameter of the through hole 33 and not greater than the diameter of the hollow portion 32, so that the second extension portion 42 is restricted to the housing 31 Inside, cannot pass through the through hole 33;
  • the elastic body 61 adopts a spring.
  • the elastic body 61 is located between the fixing member 51 and the vibrating rod 21.
  • One end of the vibrating rod 21 and one end of the fixing member 51 respectively have grooves suitable for accommodating the elastic body 61.
  • the liquid mixing system further includes:
  • a frame which is used to carry components such as chips and guide rails;
  • a carrier the carrier is arranged on the frame and is suitable for carrying a chip; for example, the bottom end of the carrier is two V-shaped detection grooves suitable for the two V-shaped detection cavities of the chip Insertion and fixation;
  • a fixed plate the fixed plate has a first through hole and a third through hole, and is arranged on the guide rail by a sliding member; when the fixed plate is in the working position, from top to bottom, the third through hole and the The first groove (first matching portion) of the linkage part of the chip on the carrier (with the safety pin removed) corresponds up and down;
  • a guide rail, the guide rail is horizontally arranged at the top end of the frame and extends along the front-to-rear direction;
  • a first motor the first motor is fixed on the fixed plate, and drives the connecting member to move up and down, thereby driving the moving member to move up and down;
  • a connecting piece the upper part of the connecting piece is on the upper side of the fixed plate, the lower part passes through the first through hole of the fixed plate, and is connected with the moving part on the lower side of the fixed plate;
  • a moving part is arranged on the lower side of the fixed plate, and the upper side of the chip moves up and down under the drive of the connecting part;
  • a second motor the second motor is fixed on the fixing plate, and the encoder is connected with the rotation shaft of the second motor, and is used to determine the position of the rotation shaft of the second motor;
  • the transmission member passes through the third through hole, and the transmission member is driven by the second motor; when the fixed plate is in the working position, the key (second mating portion) at the bottom end of the transmission member is in contact with the
  • the first groove of the linkage part of the chip is matched; in the vertical direction, the bottom end position of the transmission member is not lower than the height of the first groove, and not higher than the height of the top end of the linkage part; when the fixing When the plate moves forward along the guide rail, the bottom end of the transmission member moves forward in the second groove of the cover body and snaps into the first groove; when the fixed plate moves along the guide rail When moving backward, the bottom end of the transmission member is sequentially moved out of the first groove and the second groove, so that the detected chip is taken out and a new chip is installed;
  • a guide, at least two cylindrical guides are fixed on the upper end of the moving part
  • Guide holes, guide holes matching the number of the guide pieces are provided on the fixing plate, and are suitable for the passage of the guide pieces;
  • the chip includes a cover, a housing, a first base, a second base, and a storage device arranged from top to bottom;
  • a housing the housing has a cylindrical channel, a plurality of liquid cavities are arranged around the cylindrical channel, and are respectively used for accommodating samples and reagents, and the bottom of the liquid cavity has outlets distributed along the outer side of the cylindrical channel, such as On concentric circles or non-same circles, each outlet has a film that closes the liquid cavity;
  • the housing has a closing piece that closes multiple liquid cavities from the upper part, and the closing piece has a through hole that communicates with the inside of the liquid cavity and is suitable for adding samples Wait;
  • the safety pin has a horizontal part, the length of the horizontal part is greater than the length of the second groove, that is, the horizontal part extends outside the second groove, and is suitable for the operator to pull out the safety pin; the edge of the horizontal part
  • the two opposite sides extending in the length direction have strip-shaped protrusions extending outward, such as at the bottom end of the two sides (the left and right sides of the horizontal part, not the upper and lower sides and the front and rear sides)
  • the middle part has a strip-shaped protrusion that extends continuously or intermittently along the length direction;
  • the two side parts have a first set of grooves suitable for the end of the elastic part to be inserted into, such as Vertical grooves or inclined grooves extending up and down; the width of the end of the horizontal part becomes smaller, which is suitable for inserting into the first groove of the linkage part; in order to be beautiful and prevent dust from falling into the cylindrical channel,
  • the upper end of the end portion also has a sheet-like protrusion extending outward and along the
  • the cover is located on the upper side of the housing and closes the through hole at the upper end of the housing, such as by inserting a protrusion into the through hole to seal, so that the liquid cavity in the housing becomes a closed environment;
  • There is a second groove the second groove extends to the cylindrical channel; the linkage part of the rotating body of the first base passes through the cylindrical channel, and the upper end is in the second groove; the second groove
  • the two opposite walls of the groove have opposite wings, and the distance between the two wings is smaller than the width of the second groove; the second groove is suitable for the strip-shaped protrusion to be locked in, and the two wings block The strip-shaped protrusion moves upward, that is, prevents the housing from moving downward.
  • the horizontal part is inserted between the two wing parts; the side parts of the two wing parts facing the safety pin respectively have suspended elastic parts,
  • the elastic part processed on the wing part in the free state, the distance between the two opposite elastic parts is smaller than the width of the part with the strip-shaped protrusion of the horizontal part, when the horizontal part is inserted into the second
  • the gradually smaller width of the horizontal part passes between the two elastic parts, the distance between the two elastic parts is gradually enlarged, and finally it is locked into the first of the two side parts.
  • the first base has a fifth through hole, a second opening, and a third opening.
  • the bottom end of the first base has a concentric first opening and a first set of openings surrounding the fifth through hole.
  • the second group of openings and the eighth opening of the through holes are concentric or not on the same circumference.
  • the upper end of the second group of openings has a hollow tip-shaped protrusion, which is suitable for puncturing the film and inserting into the outlet at the lower end of the liquid cavity;
  • a base has a plurality of mutually isolated channels for communicating with the first group of openings and the second group of openings respectively, so that the first group of openings correspond to the liquid cavity in a one-to-one correspondence, and the internal communication; the first opening and the eighth opening are connected;
  • the inner diameter of the channel is small, so that the liquid in the liquid cavity cannot flow autonomously to the first set of outlets only by its own gravity;
  • the first base also has a second opening and a third opening, which are respectively connected to the eighth The outlet is connected;
  • the lower end of the first base has a fifth groove, such as a circular groove, and the fifth through hole is in the fifth groove;
  • a multi-channel directional valve includes a rotating body, and the rotating body includes:
  • the upper end of the part has a first groove; in order to cooperate with the transmission member, preferably, in the extension direction of the horizontal second groove, the width of the first groove becomes larger: the rotating disk includes a larger radius (larger than the fifth The first part of the through hole) and the second part with a smaller radius, the first part and the second part are accommodated in the fifth groove; the upper end of the rotating disk has a fourth opening, and the inside of the rotating disk has the second passage and the inside of the rotating part.
  • the second base the lower end of the second base has the mixing tank, the cross-sectional area of the mixing tank gradually increases from bottom to top;
  • the second base at the upper part of the mixing tank has a sixth through hole, and the upper end has a surrounding first A circular groove with six through holes;
  • a rubber O-ring is sleeved on the rotating part and is in the circular groove to achieve a seal between the rotating part and the mixing tank;
  • the circular groove has an annular protrusion on the periphery, the The second part is in the space enclosed by the annular protrusion and the second base, the first part is blocked by the annular protrusion;
  • the annular protrusion is in the fifth groove, and the rotating disk is in the fifth groove and the annular protrusion,
  • the rotating member extends through the sixth through hole into the mixing tank, and the distance between the bottom end of the rotating member and the bottom wall of the mixing tank is less than 1mm, such as 0.5mm; the first outside the mixing tank
  • the storage device includes a main body and a film.
  • the main body has a V-shaped detection cavity, and the film is attached to both sides of the main body;
  • the main body has a convex sixth opening and a convex seventh opening communicating with the detection cavity respectively; the sixth opening and the first The seven openings are inserted into the flexible material in the fourth groove and communicate with the second opening and the third opening;
  • the distance between the housing and the first base is greater than zero, and the second set of openings are not connected to the liquid chamber; at the same time, since the safety pin is inserted into the first groove of the linkage part, the housing Can't move down
  • a light source which emits light of multiple wavelengths
  • a first selection module configured to select excitation lights of different wavelengths from the light of multiple wavelengths, and the excitation lights are respectively incident into the V-shaped detection cavity in the V-shaped detection groove;
  • a second selection module is used to select outgoing light of different wavelengths from the light outgoing in the detection cavity;
  • a detector which converts the emitted light of different wavelengths into electrical signals
  • An incident optical fiber transmits the light emitted by different light sources into the detection cavity, and the output end of the incident optical fiber is fixed on the V-shaped groove;
  • the exit fiber transmits the light in the detection cavity to different detectors, and the input end of the exit fiber is fixed on the V-shaped groove.
  • the working mode of the above-mentioned mixing system includes a preparation phase, a mixing phase, a conveying phase, and a detection phase; the preparation phase includes the following steps:
  • the safety pin is separated from the first groove and the second groove of the cover.
  • the distance between the housing and the first base is greater than zero.
  • the liquid channel, such as the first channel, is not connected to the liquid cavity in the housing, and then the chip is placed on the carrier on the lower side of the fixed plate, and the two V-shaped grooves of the carrier carry the two V-shaped detection cavities of the storage device;
  • the transmission member passing through the fixed plate moves forward in a direction parallel to the extension direction of the guide rail, and the bottom end of the transmission member moves forward in the second groove, thereby snapping into the multi-channel selection
  • the first motor rotates to drive the moving part to move down, thereby pushing the cover to move down.
  • the lowered housing and the fixed first base are buckled together, and the second set of openings enters the outlet of the liquid chamber , Puncture the film to make the liquid channel in the first base communicate with the liquid cavity in the housing;
  • the mixing stage includes the following steps:
  • the second motor uses the transmission member to drive the linkage part, the rotating disk and the rotating member to rotate, and uses the encoder to position, so that the fourth opening on the rotating disk selectively communicates with the first group of openings; in this state, the liquid chamber is selected It is in communication with the second set of openings, the first set of openings, the fourth opening, the channel in the rotating disc and the rotating part, and the mixing tank.
  • the liquid cannot flow out of the liquid chamber to the liquid chamber by gravity alone.
  • the first group of openings at the same time, the liquid in the liquid cavity that is not in communication with the fourth opening cannot flow out to the first group of openings by relying solely on its own gravity;
  • the gas in the mixing tank is discharged from the third channel and the fifth opening in sequence, and the mixing tank becomes negative pressure;
  • the liquid in the liquid cavity sequentially breaks through and passes through the second set of openings, the channel in the first base,
  • the first set of openings, the fourth opening, the second channel and the inner channel of the rotating member enter the mixing tank, so that multiple liquids (samples and reagents) are selectively drawn from the liquid cavity and mixed in the mixing tank;
  • the temperature control unit maintains the set temperature of the mixed liquid through the heater and the refrigerator;
  • the ultrasonic vibration device is used to realize the full mixing of the liquid in the mixing tank.
  • the delivery stage includes the following steps:
  • the second motor drives the linkage part to rotate, and through the positioning of the encoder, the fourth opening on the rotating rotating disk is connected to the first opening;
  • Gas is injected into the mixing tank through the air pump and the fifth opening.
  • the liquid level in the mixing tank is positive, and the mixed liquid in the mixing tank is forced to pass through the hollow rotating member, the second channel, the fourth opening, and the first The opening, the first channel and the eighth opening, and then enter the V-shaped detection cavity in the storage device through the second opening and the third opening;
  • the detection stage includes the following steps:
  • the excitation light of different wavelengths emitted by multiple light sources is injected into each detection cavity through the incident fiber, and the first switching module is used to make part of the excitation light output by the different light sources enter the detection cavity respectively; through the second switching module, The emitted light in different detection cavities enters the detector to receive, and the parameters of the sample are obtained after analysis;
  • the electric heater is used to increase the temperature of the liquid in the detection chamber, and the airflow generated by the fan is used to reduce the temperature of the liquid in the detection chamber, so that the liquid in the detection chamber maintains a set temperature.
  • the liquid mixing system includes an ultrasonic vibration device, a temperature control unit, a mixing tank and a stirrer, and also includes:
  • a chip comprising a cover, a housing, a first base, a second base, and a storage device arranged from top to bottom;
  • Each outlet has a film that closes the liquid cavity
  • the housing has a closure piece that closes multiple liquid cavities from the upper part, and the closure piece has a through hole that communicates with the inside of the liquid cavity and is suitable for adding samples, etc.;
  • the safety pin has a horizontal part, the length of the horizontal part is greater than the length of the second groove, that is, the horizontal part extends outside the second groove, and the operator pulls out the safety pin; the edge of the horizontal part
  • the two opposite sides extending in the length direction have strip-shaped protrusions extending outward, such as at the bottom end of the two sides (the left and right sides of the horizontal part, not the upper and lower sides and the front and rear sides)
  • the middle part has a strip-shaped protrusion that extends continuously or intermittently along the length direction;
  • the two side parts have a first set of grooves suitable for the end of the elastic part to be inserted into, such as The vertical groove or the inclined groove extending in the up and down direction; the width of the end of the horizontal part becomes smaller, which is suitable for being inserted into the first groove of the linkage part; the upper end of the end has an outward and along the length
  • the top of the sheet-shaped protrusion further has a plurality of
  • the cover is located on the upper side of the housing and closes the through hole at the upper end of the housing, such as by inserting a protrusion into the through hole to seal, so that the liquid cavity in the housing becomes a closed environment;
  • There is a second groove the second groove extends to the cylindrical channel; the linkage part of the rotating body of the first base passes through the cylindrical channel, and the upper end is in the second groove; the second groove
  • the two opposite walls of the groove have opposite wings, and the distance between the two wings is smaller than the width of the second groove; the second groove is suitable for the strip-shaped protrusion to be locked in, and the two wings block The strip-shaped protrusion moves upward, that is, prevents the housing from moving downward.
  • the horizontal part is inserted between the two wing parts; the side parts of the two wing parts facing the safety pin respectively have suspended elastic parts,
  • the elastic part processed on the wing part in the free state, the distance between the two opposite elastic parts is smaller than the width of the part with the strip-shaped protrusion of the horizontal part, when the horizontal part is inserted into the second
  • the gradually smaller width of the horizontal part passes between the two elastic parts, and the distance between the two elastic parts is gradually enlarged, and finally it snaps into the first of the two side parts.
  • the first base has a fifth through hole, a second opening, and a third opening.
  • the bottom end of the first base has a concentric first opening and a first set of openings surrounding the fifth through hole.
  • the second group of openings and the eighth opening of the through holes are concentric, and the upper end of the second group of openings has a hollow tip-shaped protrusion, which is suitable for puncturing the film and inserting into the outlet at the lower end of the liquid cavity;
  • the first base has A plurality of mutually isolated channels are used to connect the first group of openings and the second group of openings respectively, so that the first group of openings correspond to the liquid cavity one-to-one and communicate with each other; the inner diameter of the channels is small, so that the liquid in the liquid cavity cannot be solely Flow to the first set of outlets autonomously by its own gravity;
  • the upper end of the first base also has a ninth opening and a tenth opening.
  • the two openings are connected through a channel in the first base, the tenth opening and the third opening are connected through a channel in the first base; the upper end of the first base has an annular protrusion, the second set of openings, the eighth opening, The ninth opening and the tenth opening are in the third groove surrounded by the annular protrusion; one side of the connecting piece has a "Y"-shaped groove, which is inverted in the third groove, so that the eighth opening and the ninth opening , The tenth opening forms a "Y"-shaped channel isolated from the outside; the second opening and the third opening are set in the fourth groove at the lower end of the first base, and outside the radius of rotation of the rotating disk, in the fourth groove Has a flexible material; the lower end of the first base has a fifth groove, and the fifth through hole is in the fifth groove;
  • a multi-channel directional valve includes a rotating body, and the rotating body includes:
  • the upper end of the part has a first groove; in the extension direction of the horizontal second groove, the width of the first groove becomes larger: in this application example, the linkage part is cylindrical and has two grooves with different widths
  • the rotating disk includes a first part with a larger radius (larger than the fifth through hole) and a second part with a smaller radius.
  • the first and second parts are accommodated in the fifth groove;
  • the upper end of the rotating disk has a fourth opening, which rotates
  • the end of the horizontal part is inserted into the first groove of the linkage part: firstly insert the groove with the larger width, then insert the groove with the smaller width, and fix it in
  • the safety pin in the second groove prevents the housing from moving downward, and the sheet-like protrusion covers the top end of the linkage part;
  • the second base the lower end of the second base has a mixing tank, from bottom to top, the cross-sectional area of the mixing tank gradually becomes larger;
  • the circular groove; the rubber O-ring is sleeved on the rotating part and is in the circular groove to realize the seal between the rotating part and the mixing tank;
  • the circular groove has an annular protrusion on the periphery, and the second part is in the annular convex In the space enclosed by the second base, the first part is blocked by the annular protrusion;
  • the annular protrusion is in the fifth groove, the rotating disk is in the fifth groove and the annular protrusion, and the second base surrounds
  • the rotating part extends into the mixing tank through the sixth through hole, and the distance between the bottom end of the rotating part and the bottom wall of the mixing tank is less than 1mm, such as 0.5mm;
  • the lower end of the second base outside the mixing tank has A convex fifth opening with a filter membrane at the fifth opening, and a third channel in the second base for connecting
  • the storage device includes a main body and a film.
  • the main body has a V-shaped detection cavity, and the film is attached to both sides of the main body;
  • the main body has a convex sixth opening and a convex seventh opening communicating with the detection cavity respectively; the sixth opening and the first The seven openings are inserted into the flexible material in the fourth groove and communicate with the second opening and the third opening;
  • the distance between the housing and the first base is greater than zero, and the second set of openings are not connected to the liquid chamber; at the same time, since the safety pin is inserted into the groove of the linkage part, the housing cannot be lowered. shift;
  • a frame the frame is used to carry the chip, the fixing plate and other components;
  • a carrier the carrier is arranged on the frame and is suitable for carrying the chip; the bottom end of the carrier is two V-shaped detection grooves, suitable for the two V-shaped detection cavities of the storage device Insertion and fixation;
  • a fixed plate the fixed plate has a third through hole and a first through hole, and is arranged on the guide rail by a sliding member; when the fixed plate is in the working position, the third through hole and the chip on the carrier (The safety pin is unplugged) the first groove corresponds up and down;
  • a guide rail, the guide rail is horizontally arranged at the top end of the frame and extends along the front-to-rear direction;
  • a second motor the second motor is fixed on the fixing plate, and the encoder is connected with the rotation shaft of the second motor, and is used to determine the position of the rotation shaft of the second motor;
  • the transmission member passes through the third through hole, and the transmission member is driven by the second motor; when the fixed plate is in the working position, the bottom end of the transmission member is clamped into the first groove; Corresponding to the first groove, in the horizontal direction, the width from one end to the other end of the bottom end of the transmission member becomes larger; in the vertical direction, the position of the bottom end of the transmission member is not lower than the first The height of a groove, and not higher than the height of the top of the linkage part; when the fixed plate moves forward along the guide rail, the bottom end of the transmission member moves forward in the second groove and Clamp into the first groove; when the fixed plate moves backward along the guide rail, the bottom end of the transmission member moves out of the first groove and the second groove in turn, so as to take out the detected chip , And load a new chip;
  • a first motor, the first motor is fixed on the fixing plate;
  • a connecting plate the upper part of the connecting plate is on the upper side of the fixed plate and has a second through hole (rectangular through hole), and the lower part passes through the first through hole of the fixed plate and is fixedly connected to the movable plate on the lower side of the fixed plate;
  • the eccentric wheel is arranged in the second through hole, and the rotating shaft of the first motor is connected to the eccentric wheel; the rotating eccentric wheel drives the connecting plate to move up and down: When the bottom wall of the through hole rotates, the connecting plate and the moving plate are driven to move down, and when the eccentric wheel rotates against the top wall of the second through hole, the connecting plate and the moving plate are driven to move;
  • a moving plate the moving plate is arranged on the lower side of the fixed plate, and the upper side of the chip has a fourth through hole suitable for the transmission member to pass through;
  • a guide, at least two cylindrical guides are fixed on the upper end of the moving plate;
  • Guide holes, guide holes matching the number of the guide pieces are provided on the fixing plate, and are suitable for the passage of the guide pieces;
  • a guide part is arranged on the upper side of the fixed plate, and the guide part is adapted to pass through the guide hole and the inside of the guide part, so as to limit the moving plate to only move up and down perpendicular to the guide part;
  • the first selection module and the second selection module are shared, and the first selection module includes:
  • a rotating part the rotating part having installation positions distributed in a concentric circle around the rotation axis;
  • a third motor drives the rotating member to rotate
  • each group of detection units includes:
  • a transmitting module and a detecting module, the transmitting module and the detecting module are respectively fixed on the installation position; the light source, the collimating lens group and the filter are respectively arranged in the transmitting module, the collimating lens group, the filter and The detector is arranged in the detection module; when the emission module that rotates with the rotating member corresponds to the incident optical fiber, the adjacent detection module corresponds to the emission optical fiber; the emission modules of each group of detection units emit excitation light of different wavelengths;
  • An incident optical fiber transmits the light emitted by the light sources in different emission modules into the detection cavity, and the output end of the incident optical fiber is fixed on the V-shaped groove;
  • the exit fiber which transmits the light in the detection cavity to different detection modules, and the input end of the exit fiber is fixed on the V-shaped groove; through rotation, the different detection units correspond to the incident fiber and the exit fiber, respectively, That is, the excitation light of different wavelengths enters the detection cavity through the incident fiber, and the fluorescence of different wavelengths excited in the detection cavity is sent to the detection module through the exit fiber to receive; in this embodiment, four groups of detection units are used to make four different wavelengths The excitation light is incident into the two detection cavities respectively, and the fluorescence of different wavelengths emitted by the detection cavities is received by the detection module respectively.
  • the working method of the liquid mixing system of this application example includes a preparation phase, a mixing phase, a conveying phase, and a detection phase; the preparation phase includes the following steps:
  • the safety pin is separated from the first groove and the second groove of the cover. The distance between the housing and the first base is greater than zero. The liquid channel and the liquid cavity in the casing are not connected, and then the chip is placed on the carrier on the lower side of the fixed plate, and the two V-shaped grooves of the carrier carry the two V-shaped detection cavities of the storage device;
  • the transmission member passing through the fixed plate moves forward in a direction parallel to the extension direction of the guide rail, and the bottom end of the transmission member moves forward in the second groove, thereby snapping into the multi-channel selection
  • the first motor rotates, driving the eccentric wheel to rotate against the bottom wall of the second through hole of the connecting plate, pushing the connecting plate down, thereby pushing the moving plate and the cover to move down, and the moving shell and the fixed part are not fixed.
  • the movable first base is buckled together, and the second set of openings enters the outlet of the liquid cavity, puncturing the film, so that the liquid channel in the first base communicates with the liquid cavity in the housing;
  • the mixing stage includes the following steps:
  • the second motor uses the transmission member to drive the linkage part, the rotating disk and the rotating member to rotate, and uses the encoder to position, so that the fourth opening on the rotating disk selectively communicates with the first group of openings; in this state, the liquid chamber is selected It is in communication with the second set of openings, the first set of openings, the fourth opening, the channel in the rotating disc and the rotating part, and the mixing tank.
  • the liquid cannot flow out of the liquid chamber to the liquid chamber by gravity alone.
  • the first group of openings at the same time, the liquid in the liquid cavity that is not in communication with the fourth opening cannot flow out to the first group of openings by relying solely on its own gravity;
  • the gas in the mixing tank is discharged from the third channel and the fifth opening in sequence, and the mixing tank becomes negative pressure;
  • the liquid in the liquid cavity sequentially breaks through and passes through the second set of openings, the channel in the first base,
  • the first set of openings, the fourth opening, the second channel and the inner channel of the rotating member enter the mixing tank, so that multiple liquids (samples and reagents) are selectively drawn from the liquid cavity and mixed in the mixing tank;
  • the temperature control unit maintains the set temperature of the mixed liquid through the heater and the refrigerator;
  • the magnetic beads are adsorbed by an electromagnet, and the magnetic beads are concentrated at the bottom of the mixing tank; and the concentrated magnetic beads are dispersed by an ultrasonic vibration device.
  • the delivery stage includes the following steps:
  • the second motor drives the linkage part to rotate, and through the positioning of the encoder, the fourth opening on the rotating rotating disk is connected to the first opening;
  • Gas is injected into the mixing tank through the air pump and the fifth opening.
  • the liquid level in the mixing tank is positive, and the mixed liquid in the mixing tank is forced to pass through the hollow rotating member, the second channel, the fourth opening, and the first The opening, the first channel and the eighth opening, and then enter the detection cavity in the storage device through the ninth opening, the tenth opening, the second opening and the third opening;
  • the detection stage includes the following steps:
  • the third motor drives the rotating member to rotate so that the detection units of different groups correspond to the incident fiber and the exit fiber, respectively.
  • the excitation light of different wavelengths output by each transmitter module is injected into the detection cavity through the incident fiber, and the detection cavity
  • the light emitted from the inside is respectively transmitted to each detection module through the output fiber, and the parameters of the sample are obtained after analysis;
  • the electric heater is used to increase the temperature of the liquid in the detection chamber, and the airflow generated by the fan is used to reduce the temperature of the liquid in the detection chamber, so that the liquid in the detection chamber maintains a set temperature.
  • the design of the guide part and the guide hole connected with the moving part ensure the downward translation of the housing, improve the stability and accuracy of the fit between the housing and the first base, that is, accurately and reliably realize the internal liquid The conduction of the flow path;
  • the mobile platform of this patent application the combination of the fixed plate, the sliding part and the horizontal guide rail realizes the automatic buckling of the housing and the first base, and at the same time realizes the accurate connection and disconnection between the transmission part and the chip, and facilitates the insertion of the chip And take out
  • the cover has a second groove extending to the rotating part, which is suitable for inserting and pulling out the safety pin and realizes the safety function; on the other hand, it is suitable for the bottom end of the transmission part to move back and forth in the second groove;
  • the bottom end of the transmission member passes through the second groove first, and then cooperates with the rotating member to drive the multi-channel selector valve to work;
  • the bottom end of the transmission member moves out of the rotating member and the first Two grooves, so as to take out the used chips and put in the new chips, the coordination is fast and accurate, without manual alignment;
  • the design with different widths of the first mating part and the corresponding design with different widths of the second mating part help the transmission part to cooperate with the rotating part and fit closely, and improve the positioning accuracy of the multi-channel directional valve.
  • An annular groove is arranged on the periphery of the sixth through hole, and the sealing member is in the annular groove and is sleeved outside the rotating member.
  • the end of the horizontal part of the safety pin far from the end inserted into the first groove has a vertical part.
  • the vertical part is exposed, which is convenient for the operator to grasp and pull.
  • the first switching module uses a combination of multiple mirrors to combine the excitation lights with different wavelengths output by the multiple emission modules.
  • the combined light is coupled into the emission fiber, and the incident fiber is split into each detection cavity. ;
  • By switching the power supply of the light source light of different wavelengths can be selectively incident into the detection cavity;
  • the output fibers corresponding to each detection cavity are combined, and then divided into multiple beams by an optical beam splitter.
  • the optical beam splitter uses a combination of a mirror and a transflective mirror, and the detection module is placed on each optical path after the beam splitting; There is an optical switch on the optical fiber, which realizes the switching function; compared with the switching of embodiment 4, no moving parts are used, which improves the stability and reliability of operation.
  • the first matching part uses a groove
  • the second matching part uses a key
  • the first matching part uses a key
  • the second matching part uses a groove

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Abstract

一种超声波振动装置和液体混合系统。超声波振动装置包括超声波震荡片（11）、振动杆（21,22）；壳体（31）内部中空，一端具有通孔（33），另一端具有固定件（51）；通孔（33）的直径小于中空部分（32）的直径；振动杆（21,22）穿过中空部分（32）和通孔（33），延伸到壳体（31）外；振动杆（21,22）的中部具有向外的第一延伸部（41）；中空部分（32）的直径不小于第一延伸部（41）的直径；第一延伸部（41）的外缘具有沿着平行于振动杆（21,22）的轴向延伸的第二延伸部（42），振动杆（21,22）、第一延伸部（41）和第二延伸部（42）围成环形凹槽；第二延伸部（42）的外径大于通孔（33）的直径，并不大于中空部分（32）的直径；弹性体（61）处于固定件（51）和振动杆（21,22）之间。以及包含超声波振动装置的液体混合系统。

Description

超声波振动装置和液体混合系统
相关申请的交叉引用
本申请要求杭州准芯生物技术有限公司于2020年06月12日提交的、发明名称为“超声波振动装置和液体混合系统”的、中国专利申请号“2020105377796”的优先权。
技术领域
本申请涉及液体检测，特别涉及超声波振动装置及液体混合系统。
背景技术
在各类分析中，需要将样本以及多种试剂分别加到混合腔内，如试管中。这些样本可以是人类和动物的样本，如全血、血浆、血清、尿液、唾液、粪便、脑脊液或灌洗液，蜡封组织以及切片、组织匀浆液，还可以是植物，包括中药、食品原料、加工食品、肉类、饮料酒类以及饮品制造工艺中得原料以及半成品，还可以是细胞培养液或病菌病毒培养液，分析的成分种类包括矿物质、无机物质、有机物质、核酸DNA、RNA、蛋白质或脂肪。目前，液体混合主要采用以下手段：
1.机械振荡，将混合池放置在机械振荡平台上，来回晃荡混合池，使得混合池内的多种液体混合均匀。这种方案的不足在于：
混合池无法固定，需要移来移去，无法实现一体化操作，工作效率低；机械振荡平台体积大；混合效果较差。
2.电磁搅拌；混合池内设置搅拌子，利用电磁方式驱动搅拌子搅拌液体。该方案的不足主要在于：
混合池的体积较小，搅拌子旋转空间有限，混合效果差；装置体积大。
发明内容
为了解决上述现有技术方案中的不足，本申请提供了一种结构简单、体积小的超声波振动装置。
根据本申请的超声波振动装置，所述超声波震荡片、振动杆；所述超声波振动装置还包括：
壳体，所述壳体内部中空，一端具有通孔，另一端固定有固定件；所述通孔的直径小于中空部分的直径；所述振动杆穿过所述中空部分和通孔，延伸到壳体外；
第一延伸部，所述振动杆的中部具有向外的第一延伸部；所述中空部分的直径不小于所 述第一延伸部的直径；
第二延伸部，所述第一延伸部的外缘具有沿着平行于振动杆的轴向的方向延伸的第二延伸部，所述振动杆、第一延伸部和第二延伸部围成环形凹槽；所述第二延伸部的外径大于所述通孔的直径，并不大于所述中空部分的直径；
弹性体，所述弹性体处于所述固定件和振动杆之间。
本申请的目的还在于提供了应用上述超声波振动装置的液体混合系统，该目的是通过以下技术方案得以实现的：
液体混合系统，所述液体混合系统包括混合池和搅拌子；所述液体混合系统还包括：
振动单元，所述振动单元采用上述的超声波振动装置，并设置在所述混合池的下侧；所述振动杆的端部抵住所述混合池的底端。
本申请的液体混合系统结构简单、体积小；利用超声波振动技术实现混合池内液体的振动混合，超声波振动装置结构简单，占用体积小，混合池固定设置，无需移动；混合效果好；利用小幅度的超声波振动，配合混合池内的搅拌子，实现混合均匀、高效的目的；混合池的上宽下窄的内径变小设计，进一步地提高了混合效果；延伸部、第一部分和第二部分的设计，进一步提高了振动效果，也即提高了液体混合效果；多功能；温控单元实现了混合池内液体的加热和制冷，体积小、控温效果好；温控单元与混合池的形状匹配，进一步提高了温控效果。
附图说明
图1为本申请的超声波振动装置的结构简图。
具体实施方式
图1和以下说明描述了本申请的可选实施方式以教导本领域技术人员如何实施和再现本申请。为了教导本申请技术方案，已简化或省略了一些常规方面。本领域技术人员应该理解源自这些实施方式的变型或替换将在本申请的范围内。本领域技术人员应该理解下述特征能够以各种方式组合以形成本申请的多个变型。由此，本申请并不局限于下述可选实施方式，而仅由权利要求和它们的等同物限定。
实施例1：
图1示意性地给出了本申请实施例的超声波振动装置的基本结构图，如图1所示，所述超声波振动装置包括：
超声波震荡片11、振动杆21-22；超声波震荡片和振动杆是本领域的现有技术，具体结构和工作方式在此不再赘述；
壳体31，所述壳体31内部中空，一端具有通孔33，另一端具有固定件51，固定件51通过螺栓等固定在壳体31上；所述通孔33的直径小于中空部分32的直径；所述振动杆21-22穿过所述中空部分32和通孔33，延伸到壳体31外；
第一延伸部41，所述振动杆的中部具有向外的第一延伸部41；所述中空部分32的直径不小于所述第一延伸部41的直径，使得第一延伸部41处于壳体31内；
第二延伸部42，所述第一延伸部41的外缘具有沿着平行于振动杆的轴向延伸的第二延伸部42，所述振动杆21-22、第一延伸部41和第二延伸部42围成环形凹槽；所述第二延伸部42的外径大于所述通孔33的直径，并不大于所述中空部分32的直径，使得第二延伸部42被限制在壳体31内，无法穿过所述通孔33；
弹性体61，所述弹性体61处于所述固定件51和振动杆21之间。
为了便于制造，在本申请的一个实施例中，所述的第一延伸部沿着振动杆的径向延伸。
为了增大振动振幅，在本申请的一个实施例中，所述振动杆包括：
第一部分21，沿着固定件51到弹性体61的方向上，第一部21分和第二部分22依次设置，第一部分21直径大于所述第二部分22；
第二部分22，所述第二部分22延伸到所述壳体31外，端部形状与待振动对象匹配。
为了稳固地连接，防止振动中错位，在本申请的一个实施例中，所述端部形状为内凹的曲面。
为了提高振动中的可靠性，防止错位，在本申请的一个实施例中，所述振动杆和/或固定件的一端具有凹槽，所述弹性体的一端处于该凹槽内。
实施例2：
根据本申请实施例1的超声波振动装置在液体混合系统中的应用例。
在本应用例中，如图1所示，所述液体混合系统包括：
混合池和搅拌子；混合池为塑料材质，自上而下地，所述混合池的内径逐渐变小，底端外壁为外凸的曲面；搅拌子采用磁珠；
温控单元，所述温控单元采用金属材质，呈环形套在所述混合池外，内壁与所述混合池的外壁(外凸的曲面)匹配，电加热体设置在所述温控单元内；混合池的底端延伸到温控单元下侧；TEC制冷器的冷端贴着所述温控单元，热端贴着散热器；风扇产生的气流吹扫所述散热器；
超声波振动装置，包括：
超声波震荡片11，超声波震荡片11是本领域的现有技术，具体结构和工作方式在此不再赘述；
振动杆，所述振动杆包括：
第一部分21，沿着固定件51到弹性体61的方向上，第一部分21和第二部分22依次设置，第一部分21直径大于所述第二部分22；
第二部分22，所述第二部分22延伸到所述壳体31外，端部为内凹的曲面，与混合池的底端形状匹配，使得第二部分22的端部牢固地抵住混合池的底端而不松脱；
壳体31，所述壳体31内部中空，一端具有通孔33，另一端具有固定件51；所述通孔33的直径小于中空部分32的直径；所述振动杆22穿过所述中空部分32和通孔33，延伸到壳体31外；
第一延伸部41，所述振动杆21的中部具有沿着振动杆的径向向外的第一延伸部41；所述中空部分32的直径不小于所述第一延伸部41的直径，使得第一延伸部41处于壳体31内；
第二延伸部42，所述第一延伸部41的外缘具有沿着平行于振动杆21的轴向延伸的第二延伸部42，所述振动杆21、第一延伸部41和第二延伸部42围成环形凹槽；所述第二延伸部42的外径大于所述通孔33的直径，并不大于所述中空部分32的直径，使得第二延伸部42被限制在壳体31内，无法穿过所述通孔33；
弹性体61，采用弹簧，所述弹性体61处于所述固定件51和振动杆21之间，振动杆21的一端和固定件51的一端分别具有适于容纳弹性体61的凹槽。
实施例3：
根据本申请实施例2的液体混合系统的应用例，所述液体混合系统还包括：
框架，所述框架用于承载芯片、导轨等部件；
承载件，所述承载件设置在所述框架上，并适于承载芯片；如，所述承载件的底端为二个V形检测槽，适于所述芯片的二个V形检测腔的插入和固定；
固定板，所述固定板具有第一通孔和第三通孔，并通过滑动件设置在导轨上；当所述固定板处于工作位时，自上而下地，所述第三通孔和处于承载件上的芯片(拔掉了安全销)的联动部分的第一凹槽(第一配合部)上下对应；
导轨，所述导轨水平地设置在所述框架的顶端，并沿着前后方向延伸；
第一电机，所述第一电机固定在所述固定板上，驱动连接件上下移动，进而带动移动件上下运动；
连接件，所述连接件的上部处于固定板上侧，下部穿过固定板的第一通孔，并与固定板下侧的移动件连接；
移动件，所述移动件设置在所述固定板的下侧，所述芯片的上侧，在连接件的驱动下上下移动；
第二电机，所述第二电机固定在所述固定板上，编码器与第二电机的转动轴连接，用于 确定第二电机的转轴的位置；
传动件，所述传动件穿过所述第三通孔，传动件被所述第二电机驱动；当所述固定板处于工作位时，传动件的底端的键(第二配合部)与所述芯片的联动部分的第一凹槽配合；在竖直方向上，所述传动件的底端位置不低于第一凹槽的高度，且不高于联动部分的顶端高度；当所述固定板沿着所述导轨向前移动时，所述传动件的底端在盖体的第二凹槽内向前移动并卡入所述第一凹槽；当所述固定板沿着所述导轨向后移动时，所述传动件的底端依次移出第一凹槽和第二凹槽，从而拿出检测过的芯片，并装入新的芯片；
导向件，至少二个圆柱状的导向件固定在所述移动件的上端；
导向孔，与所述导向件数量匹配的导向孔设置在所述固定板上，适于所述导向件的穿过；
所述芯片包括自上而下地设置的盖体、壳体、第一基座、第二基座和存储装置；
壳体，所述壳体内具有柱形通道，多个液体腔围绕柱形通道设置，分别用于容纳样本和试剂，液体腔的底部具有沿着所述柱形通道的外侧分布的出口，如呈同心圆或非同一圆周上，每个出口处具有封闭液体腔的薄膜；壳体具有的封闭件从上部封闭多个液体腔，所述封闭件具有通孔与液体腔内部连通，适于加入样本等；
安全销，所述安全销具有水平部分，水平部分的长度大于第二凹槽的长度，也即水平部分延伸到第二凹槽外，适于操作者拉出安全销；所述水平部分的沿着长度方向延伸的位置相对的二个侧部具有向外延伸的条状凸起，如在二个侧部(水平部分的左右二个侧部，非上下侧部和前后侧部)的底端或中部具有条状凸起，所述条状凸起沿着所述长度方向连续或间断地延伸；所述二个侧部具有适于弹性部的端部卡入的第一组凹槽，如上下方向延伸的竖直凹槽或倾斜凹槽；所述水平部分的端部的宽度变小，适于插入联动部分的第一凹槽；为了美观及防止灰尘等落入柱形通道内，所述端部的上端还具有向外及沿着长度方向延伸的片状凸起；为了便于抽出安全销，片状凸起的顶端进一步具有与所述长度方向垂直(即宽度方向)延伸的多条凸起；所述水平部分采用非实心的中空结构；固定在第二凹槽内的安全销阻止了壳体的向下移动，所述片状凸起遮盖了联动部分的顶端；
盖体，所述盖体处于所述壳体的上侧，封闭壳体的上端通孔，如利用凸起插入通孔内封闭，使得壳体内的液体腔内成为封闭的环境；所述盖体内具有第二凹槽，所述第二凹槽延伸到所述柱形通道；第一基座的旋转体的联动部分穿过所述柱形通道，上端处于第二凹槽；所述第二凹槽的相对的两壁具有相对设置的翼部，二个翼部间的距离小于第二凹槽的宽度；第二凹槽适于所述条状凸起的卡入，二个翼部阻挡了条状凸起向上移动，也即阻止了壳体的向下移动，所述水平部分插入所述二个翼部之间；二个翼部临着安全销的侧部分别具有悬空的弹性部，如翼部上加工出的弹性部，在自由状态下，位置相对的二个弹性部之间的距离小于所述水平部分的具有条状凸起的部分的宽度，当所述水平部分插入第二凹槽内时， 水平部分的宽度逐渐变小的部分从二个弹性部的之间穿过，二个弹性部之间的距离逐渐被撑大，最后卡入所述二个侧部的第一组凹槽内；
第一基座具有第五通孔、第二开口和第三开口，第一基座的底端具有环绕第五通孔的呈同心圆的第一开口和第一组开口，上端具有环绕第五通孔的呈同心圆或非同一圆周上的第二组开口和第八开口，第二组开口上端具有中空的尖端状凸起，适于戳破薄膜，并插入液体腔下端的出口内；第一基座内具有多个相互隔离的通道，用于分别连通第一组开口和第二组开口，使得第一组开口与液体腔一一对应，内部连通；第一开口和第八开口连通；通道内径较小，使得液体腔内的液体不能仅依靠自身重力而自主地流到第一组出口处；所述第一基座上还具有第二开口和第三开口，分别与所述第八出口连通；第一基座的下端具有第五凹槽，如圆形凹槽，所述第五通孔处于所述第五凹槽内；
多通道选向阀，所述多通道选向阀包括旋转体，所述旋转体包括：
自上而下的中心轴线共线的联动部分、旋转盘和空心转动件；联动部分穿过所述第五通孔并处于所述柱形通道内；所述联动部分的处于第二凹槽内的部分上端具有第一凹槽；为了与传动件配合，优选地，在水平的第二凹槽延伸方向上，所述第一凹槽的宽度变大：旋转盘包括半径较大(大于第五通孔)的第一部分和半径较小的第二部分，第一部分和第二部分容纳在第五凹槽内；旋转盘的上端具有第四开口，旋转盘内部具有第二通道与转动件的内部连通；当旋转盘转动时，第四开口分别与第一开口、第一组开口连通，实现了选择性地连通第一开口、第一组开口，也即实现转动件内部选择性地与液体腔连通；
第二基座，第二基座的下端具有所述混合池，自下而上地，混合池的截面积逐渐变大；混合池上部的第二基座具有第六通孔、上端有围绕第六通孔的圆形凹槽；橡胶O形圈套在转动件上并处于该圆形凹槽内，实现了转动件和混合池间的密封；该圆形凹槽外围具有环形凸起，所述第二部分处于环形凸起和第二基座围成的空间内，所述第一部分被环形凸起阻挡；环形凸起处于第五凹槽内，旋转盘处于第五凹槽和环形凸起、第二基座围出的空间内；转动件穿过第六通孔伸入到混合池内，转动件的底端和混合池的底壁间的距离小于1mm，如0.5mm；混合池外的第二基座的下端具有第五开口，第五开口处具有过滤膜，第二基座内具有第三通道，用于连通所述混合池和第五开口；
气泵，所述气泵连连通所述第五开口；
存储装置包括主体和薄膜，主体内具有V形检测腔，薄膜贴在主体两侧；主体上具有分别与检测腔连通的凸起状第六开口和凸起状第七开口；第六开口和第七开口插入第四凹槽内的柔性材料内，并与第二开口、第三开口连通；
在正式检测前，所述壳体和第一基座间的距离大于零，第二组开口与液体腔室不连通的；同时，鉴于安全销插入联动部分的第一凹槽内，使得壳体无法下移；
光源，所述光源发出多种波长的光；
第一选择模块，所述第一选择模块用于在所述多种波长的光中选择出不同波长的激发光，激发光分别入射进所述V形检测槽内的V形检测腔内；
第二选择模块，所述第二选择模块用于在所述检测腔内出射的光中选择出不同波长的出射光；
探测器，所述探测器将不同波长的出射光转换为电信号；
入射光纤，所述入射光纤将不同光源发出的光传输到所述检测腔内，入射光纤的输出端固定在V形槽上；
出射光纤，所述出射光纤将所述检测腔内的光传输到不同探测器，出射光纤的输入端固定在V形槽上。
上述混合系统的工作方式包括准备阶段、混合阶段、输送阶段和检测阶段；所述准备阶段包括以下步骤：
(A1)向后推动固定板，所述固定板沿着导轨向后运动；
拉出芯片上的安全销，所述安全销先后脱离第一凹槽和盖体的第二凹槽，所述壳体和第一基座间的距离大于零，所述第一基座内的液体通道如第一通道和所述壳体内的液体腔不连通，之后将芯片放置在固定板下侧的承载件上，承载件的二个V形槽承载存储装置的二个V形检测腔；
(A2)向前拉动所述固定板，所述固定板沿着所述导轨向前运动；
穿过所述固定板的传动件沿着平行于所述导轨的延伸方向的方向向前移动，所述传动件的底端在所述第二凹槽内向前运动，从而卡入多通道选向阀的联动部分的上端的第一凹槽，使得第二电机通过所述传动件驱动所述联动部分、旋转盘旋转；
(A3)第一电机转动，驱动移动件下移，从而推动盖体向下移动，下移的壳体和固定不动的第一基座扣在一起，第二组开口进入液体腔的出口内，戳破薄膜，使得所述第一基座内的液体通道和所述壳体内的液体腔连通；
所述混合阶段包括以下步骤：
所述第二电机利用所述传动件驱动联动部分、旋转盘和转动件转动，利用编码器定位，使得旋转盘上的第四开口选择性地连通第一组开口；此状态下，液体腔选择性地与第二组开口、第一组开口、第四开口、旋转盘和转动件内通道、混合池是连通的，但鉴于窄小通道的阻力，液体未能仅依靠重力而流出液体腔到第一组开口；同时，未与第四开口连通的液体腔内的液体也未能仅依靠自身重力而流出到第一组开口；
气泵工作，混合池内的气体依次从所述第三通道、第五开口排出，所述混合池内成为负压；液体腔内的液体依次突破并穿过第二组开口、第一基座内通道、第一组开口、第四开 口、第二通道和转动件内通道而进入混合池内，从而实现了多种液体(样本和试剂)分别从液体腔内选择性地抽出，并在混合池内混合；
在混合池内的混合液体反应过程中，温控单元通过加热器和制冷器使得混合液体维持设定温度；
利用超声波振动装置实现了混合池内液体的充分混合。
所述输送阶段包括以下步骤：
第二电机驱动所述联动部分转动，通过编码器的定位，使得转动的旋转盘上的第四开口连通第一开口；
通过所述气泵和所述第五开口向所述混合池内注入气体，混合池内液面上为正压，压迫混合池内的混合液体依次穿过空心转动件、第二通道、第四开口、第一开口、第一通道和第八开口，再通过第二开口和第三开口进入存储装置内的V形检测腔内；
所述检测阶段包括以下步骤：
(B1)多个光源发出的不同波长的激发光通过入射光纤射入各个检测腔内，利用第一切换模块，使得部分不同光源输出的激发光分别进入检测腔内；通过第二切换模块，使得不同检测腔内的出射光进入检测器接收，通过分析后获得样本的参数；
利用电加热片提升检测腔内的液体温度，利用风机产生的气流降低检测腔内的液体温度，使得检测腔内的液体维持设定的温度。
实施例4：
根据本申请实施例3的液体混合系统在荧光定量PCR中的应用例。
在该应用例中，液体混合系统包括超声波振动装置、温控单元、混合池和搅拌子，还包括：
芯片，所述芯片包括自上而下地设置的盖体、壳体、第一基座、第二基座和存储装置；
壳体，所述壳体内具有圆柱形通道，多个液体腔围绕该圆柱形通道设置，分别用于容纳样本和试剂，液体腔的底部具有沿着所述圆柱形通道的中心轴线呈同心圆分布的出口，每个出口处具有封闭液体腔的薄膜；壳体具有的封闭件从上部封闭多个液体腔，所述封闭件具有通孔与液体腔内部连通，适于加入样本等；
安全销，所述安全销具有水平部分，水平部分的长度大于第二凹槽的长度，也即水平部分延伸到第二凹槽外，并与操作者拉出安全销；所述水平部分的沿着长度方向延伸的位置相对的二个侧部具有向外延伸的条状凸起，如在二个侧部(水平部分的左右二个侧部，非上下侧部和前后侧部)的底端或中部具有条状凸起，所述条状凸起沿着所述长度方向连续或间断地延伸；所述二个侧部具有适于弹性部的端部卡入的第一组凹槽，如上下方向延伸的竖直凹槽或倾斜凹槽；所述水平部分的的端部的宽度变小，适于插入联动部分的第一凹 槽；所述端部的上端具有向外及沿着长度方向延伸的片状凸起；为了便于抽出安全销，片状凸起的顶端进一步具有与所述长度方向垂直(即宽度方向)延伸的多条凸起；所述水平部分采用非实心的中空结构；
盖体，所述盖体处于所述壳体的上侧，封闭壳体的上端通孔，如利用凸起插入通孔内封闭，使得壳体内的液体腔内成为封闭的环境；所述盖体内具有第二凹槽，所述第二凹槽延伸到所述圆柱形通道；第一基座的旋转体的联动部分穿过所述圆柱形通道，上端处于第二凹槽；所述第二凹槽的相对的两壁具有相对设置的翼部，二个翼部间的距离小于第二凹槽的宽度；第二凹槽适于所述条状凸起的卡入，二个翼部阻挡了条状凸起向上移动，也即阻止了壳体的向下移动，所述水平部分插入所述二个翼部之间；二个翼部临着安全销的侧部分别具有悬空的弹性部，如翼部上加工出的弹性部，在自由状态下，位置相对的二个弹性部之间的距离小于所述水平部分的具有条状凸起的部分的宽度，当所述水平部分插入第二凹槽内时，水平部分的宽度逐渐变小的部分从二个弹性部的之间穿过，二个弹性部之间的距离逐渐被撑大，最后卡入所述二个侧部的第一组凹槽内；
第一基座具有第五通孔、第二开口和第三开口，第一基座的底端具有环绕第五通孔的呈同心圆的第一开口和第一组开口，上端具有环绕第五通孔的呈同心圆的第二组开口和第八开口，第二组开口上端具有中空的尖端状凸起，适于戳破薄膜，并插入液体腔下端的出口内；第一基座内具有多个相互隔离的通道，用于分别连通第一组开口和第二组开口，使得第一组开口与液体腔一一对应，内部连通；通道内径较小，使得液体腔内的液体不能仅依靠自身重力而自主地流到第一组出口处；第一基座上端还具有第九开口和第十开口，第八开口与第一开口通过第一基座内的通道连通，第九开口与第二开口通过第一基座内的通道连通，第十开口与第三开口通过第一基座内的通道连通；第一基座上端具有环形凸起，所述第二组开口、第八开口、第九开口和第十开口处于环形凸起围出的第三凹槽内；连接件的一侧具有“Y”形凹槽，倒扣在第三凹槽内，使得第八开口与第九开口、第十开口间形成与外界隔离的“Y”形通道；第二开口和第三开口设置第一基座下端的第四凹槽内，并在旋转盘的旋转半径外，第四凹槽内具有柔性材料；第一基座的下端具有第五凹槽，所述第五通孔处于所述第五凹槽内；
多通道选向阀，所述多通道选向阀包括旋转体，所述旋转体包括：
自上而下的中心轴线共线的联动部分、旋转盘和空心转动件；联动部分穿过所述第五通孔并处于所述圆柱形通道内；所述联动部分的处于第二凹槽内的部分上端具有第一凹槽；在水平的第二凹槽延伸方向上，所述第一凹槽的宽度变大：本应用例中，联动部分为筒状，具有二个宽度不同的凹槽；旋转盘包括半径较大(大于第五通孔)的第一部分和半径较小的第二部分，第一部分和第二部分容纳在第五凹槽内；旋转盘的上端具有第四开口，旋转 盘内部具有第二通道与转动件的内部连通；当旋转盘转动时，第四开口分别与第一开口、第一组开口连通，实现了选择性地连通第一开口、第一组开口，也即实现转动件内部选择性地与液体腔连通；所述水平部分的端部插入所述联动部分的第一凹槽内：先插入宽度较大的槽，再插入宽度较小的槽，固定在第二凹槽内的安全销阻止了壳体的向下移动，所述片状凸起遮盖了联动部分的顶端；
第二基座，第二基座的下端具有混合池，自下而上地，混合池的截面积逐渐变大；混合池上部的第二基座具有第六通孔、围绕第六通孔的圆形凹槽；橡胶O形圈套在转动件上并处于圆形凹槽内，实现了转动件和混合池间的密封；圆形凹槽外围具有环形凸起，所述第二部分处于环形凸起和第二基座围成的空间内，所述第一部分被环形凸起阻挡；环形凸起处于第五凹槽内，旋转盘处于第五凹槽和环形凸起、第二基座围出的空间内；转动件穿过第六通孔伸入到混合池内，转动件的底端和混合池的底壁间的距离小于1mm，如0.5mm；混合池外的第二基座的下端具有凸起状的第五开口，第五开口处具有过滤膜，第二基座内具有第三通道，用于连通所述混合池和第五开口；
气泵，所述气泵连连通所述第五开口；
存储装置包括主体和薄膜，主体内具有V形检测腔，薄膜贴在主体两侧；主体上具有分别与检测腔连通的凸起状第六开口和凸起状第七开口；第六开口和第七开口插入第四凹槽内的柔性材料内，并与第二开口、第三开口连通；
在正式检测前，所述壳体和第一基座间的距离大于零，第二组开口与液体腔室不连通的；同时，鉴于安全销插入联动部分的凹槽内，使得壳体无法下移；
框架，所述框架用于承载所述芯片、固定板等部件；
承载件，所述承载件设置在所述框架上，并适于承载所述芯片；所述承载件的底端为二个V形检测槽，适于所述存储装置的二个V形检测腔的插入和固定；
固定板，所述固定板具有第三通孔和第一通孔，并通过滑动件设置在导轨上；当所述固定板处于工作位时，所述第三通孔和处于承载件上的芯片(拔掉了安全销)的所述第一凹槽上下对应；
导轨，所述导轨水平设置在所述框架的顶端，并沿着前后方向延伸；
第二电机，所述第二电机固定在所述固定板上，编码器与第二电机的转动轴连接，用于确定第二电机的转轴的位置；
传动件，所述传动件穿过所述第三通孔，传动件被所述第二电机驱动；当所述固定板处于工作位时，传动件的底端卡入所述第一凹槽；与所述第一凹槽相对应的，在水平方向上，所述传动件的底端的一端到另一端的宽度变大；在竖直方向上，所述传动件的底端位置不低于第一凹槽的高度，且不高于联动部分的顶端高度；当所述固定板沿着所述导轨向前移 动时，所述传动件的底端在所述第二凹槽内向前移动并卡入所述第一凹槽；当所述固定板沿着所述导轨向后移动时，所述传动件的底端依次移出第一凹槽和第二凹槽，从而拿出检测过的芯片，并装入新的芯片；
第一电机，所述第一电机固定在所述固定板上；
连接板，所述连接板的上部处于固定板上侧，且具有第二通孔(矩形通孔)，下部穿过固定板的第一通孔，并与固定板下侧的移动板固定连接；
偏心轮，所述偏心轮设置在所述第二通孔内，所述第一电机的转轴连接所述偏心轮；旋转的偏心轮驱动所述连接板的上下移动：当偏心轮顶着第二通孔的底壁转动时，驱动连接板和移动板下移，当偏心轮顶着第二通孔的顶壁转动时，驱动连接板和移动板上移；
移动板，所述移动板设置在所述固定板的下侧，所述芯片的上侧，具有适于所述传动件穿过的第四通孔；
导向件，至少二个圆柱状的导向件固定在所述移动板的上端；
导向孔，与所述导向件数量匹配的导向孔设置在所述固定板上，适于所述导向件的穿过；
导向部件，所述导向部件设置在所述固定板的上侧，导向件适于穿过导向孔和导向部件内部，从而限定移动板仅能垂直于导向件地上下移动；
第一选择模块和第二选择模块共用，第一选择模块包括：
旋转件，所述旋转件具有绕着转动轴呈同心圆分布的安装位；
第三电机，所述第三电机驱动所述旋转件转动；
多组检测单元，每组检测单元包括：
一个发射模块和一个探测模块，所述发射模块和探测模块分别固定在所述安装位上；光源、准直透镜组和滤光片分别设置在发射模块内，准直透镜组、滤光片和探测器设置在所述探测模块内；当随着旋转件转动的发射模块与入射光纤对应时，相邻的探测模块与出射光纤对应；每一组检测单元的发射模块出射不同波长的激发光；
入射光纤，所述入射光纤将不同发射模块内的光源发出的光传输到所述检测腔内，入射光纤的输出端固定在V形槽上；
出射光纤，所述出射光纤将所述检测腔内的光传输到不同探测模块内，出射光纤的输入端固定在V形槽上；通过旋转，使得不同检测单元分别与入射光纤、出射光纤对应，也即，不同波长的激发光通过入射光纤进入检测腔内，检测腔内激发出的不同波长的荧光通过出射光纤送检测模块接收；本实施例中，采用四组检测单元，使得四种不同波长的激发光分别入射到二个检测腔中，检测腔出射的不同波长的荧光分别被探测模块接收。
本应用例的液体混合系统的工作方法，包括准备阶段、混合阶段、输送阶段和检测阶段；所述准备阶段包括以下步骤：
(A1)向后推动固定板，所述固定板沿着导轨向后运动；
拉出芯片上的安全销，所述安全销先后脱离第一凹槽和盖体的第二凹槽，所述壳体和第一基座间的距离大于零，所述第一基座内的液体通道和所述壳体内的液体腔不连通，之后将芯片放置在固定板下侧的承载件上，承载件的二个V形槽承载存储装置的二个V形检测腔；
(A2)向前拉动所述固定板，所述固定板沿着所述导轨向前运动；
穿过所述固定板的传动件沿着平行于所述导轨的延伸方向的方向向前移动，所述传动件的底端在所述第二凹槽内向前运动，从而卡入多通道选向阀的联动部分的上端的第一凹槽，使得第二电机通过所述传动件驱动所述联动部分的旋转；
(A3)第一电机转动，驱动偏心轮顶着连接板的第二通孔的底壁旋转，推动连接板下移，从而推动移动板和盖体向下移动，下移的壳体和固定不动的第一基座扣在一起，第二组开口进入液体腔的出口内，戳破薄膜，使得所述第一基座内的液体通道和所述壳体内的液体腔连通；
所述混合阶段包括以下步骤：
所述第二电机利用所述传动件驱动联动部分、旋转盘和转动件转动，利用编码器定位，使得旋转盘上的第四开口选择性地连通第一组开口；此状态下，液体腔选择性地与第二组开口、第一组开口、第四开口、旋转盘和转动件内通道、混合池是连通的，但鉴于窄小通道的阻力，液体未能仅依靠重力而流出液体腔到第一组开口；同时，未与第四开口连通的液体腔内的液体也未能仅依靠自身重力而流出到第一组开口；
气泵工作，混合池内的气体依次从所述第三通道、第五开口排出，所述混合池内成为负压；液体腔内的液体依次突破并穿过第二组开口、第一基座内通道、第一组开口、第四开口、第二通道和转动件内通道而进入混合池内，从而实现了多种液体(样本和试剂)分别从液体腔内选择性地抽出，并在混合池内混合；
在混合池内的混合液体反应过程中，温控单元通过加热器和制冷器使得混合液体维持设定温度；
混合液体中有磁珠(搅拌子)，利用电磁铁吸附磁珠，磁珠集聚在混合池的底部；利用超声波振动装置驱散集聚的磁珠。
所述输送阶段包括以下步骤：
第二电机驱动所述联动部分转动，通过编码器的定位，使得转动的旋转盘上的第四开口连通第一开口；
通过所述气泵和所述第五开口向所述混合池内注入气体，混合池内液面上为正压，压迫混合池内的混合液体依次穿过空心转动件、第二通道、第四开口、第一开口、第一通道和 第八开口，再通过第九开口、第十开口、第二开口和第三开口进入存储装置内的检测腔内；
所述检测阶段包括以下步骤：
(B1)第三电机驱动旋转件转动，使得不同组的检测单元分别与入射光纤和出射光纤对应，各个发射模块输出的不同波长的激发光分别通过入射光纤射入检测腔内，所述检测腔内出射的光分别通过出射光纤传输到各个检测模块，通过分析后获得样本的参数；
利用电加热片提升检测腔内的液体温度，利用风机产生的气流降低检测腔内的液体温度，使得检测腔内的液体维持设定的温度。
根据本申请实施例达到的益处在于：
1.自动化扣合；
在加入样本后，拉出安全销，利用第一电机、连接单元和移动件的组合，利用下移的移动件推动壳体下移，壳体和第一基座扣合，内部流路连通，实现了自动化扣合，且不影响多通道选向阀内部件的转动，无需人工按压，自动、耗时短、准确；
与移动件连接的导向件以及导向孔的设计，保证了壳体的向下平移，提高了壳体和第一基座间配合的稳定性和准确性，也即准确、可靠地实现了内部液体流路的导通；
2.结构简单；
本专利申请的移动平台：固定板、滑动件和水平导轨的组合，实现了壳体和第一基座的自动化扣合，同时实现了传动件和芯片间准确连接与脱离，便于芯片的放入和取出；
3.工作效率高；
盖体上具有延伸到转动件的第二凹槽，一方面适于安全销的插入和拉出，实现了安全功能，另一方面适于传动件的底端在第二凹槽内前后移动；当正向移动时，传动件的底端先穿过第二凹槽，再与转动件配合，进而驱动多通道选向阀工作；当反向移动时，传动件的底端移出转动件和第二凹槽，从而取出用过的芯片，放入新的芯片，配合快捷、准确，无需人工对准；
4.工作性能好；
第一配合部的宽度不同的设计，以及对应的第二配合部的宽度不同的设计，有助于传动件配合转动件并紧密配合，提高了多通道选向阀的定位精度。
实施例5：
根据本申请实施例3的液体混合系统在荧光定量PCR中的应用例，与实施例4不同的是：
1.各个液体腔的底端开口非同心圆分布，第一组开口也非同心圆分布。
2.在第六通孔的外围设置环形槽，密封件处于环形槽内，且套在转动件外。
3.安全销的水平部分的远离插入第一凹槽的端部的端部还有竖直部分，当安全销插入第二凹槽内时，竖直部分外露，便于操作人员握持外拉。
4.第一切换模块采用多个反射镜的组合，用于将多个发射模块输出的波长不同的激发光合束，合束光被耦合进入射光纤，入射光纤分束后入射到各个检测腔内；通过开关光源的电源实现不同波长光选择性地入射到检测腔内；
对应各个检测腔的出射光纤合束，再经过光分束器分为多束，光分束器采用反射镜和透反镜的组合，检测模块分别放置在分束后的每个光路上；出射光纤上具有光开关，实现了切换功能；与实施例4的切换相比，不再使用运动部件，提高了运行稳定性和可靠性。
上述实施例中，第一配合部采用凹槽，第二配合部采用键，当然还可以互换，第一配合部采用键，第二配合部采用凹槽。

Claims (10)

  1. 一种超声波振动装置，所述超声波震荡片、振动杆；其特征在于：所述超声波振动装置还包括：
    壳体，所述壳体内部中空，一端具有通孔，另一端固定有固定件；所述通孔的直径小于中空部分的直径；所述振动杆穿过所述中空部分和通孔，延伸到壳体外；
    第一延伸部，所述振动杆的中部具有向外的第一延伸部；所述中空部分的直径不小于所述第一延伸部的直径；
    第二延伸部，所述第一延伸部的外缘具有沿着平行于振动杆的轴向的方向延伸的第二延伸部，所述振动杆、第一延伸部和第二延伸部围成环形凹槽；所述第二延伸部的外径大于所述通孔的直径，并不大于所述中空部分的直径；
    弹性体，所述弹性体处于所述固定件和振动杆之间。
  2. 根据权利要求1所述的超声波振动装置，其特征在于：所述第一延伸部沿着振动杆的径向延伸。
  3. 根据权利要求1或2所述的超声波振动装置，其特征在于：所述振动杆包括：
    第一部分，沿着固定件到弹性体的方向上，第一部分和第二部分依次设置，第一部分直径大于所述第二部分；
    第二部分，所述第二部分延伸到所述壳体外，端部形状与待振动对象匹配。
  4. 根据权利要求3所述的超声波振动装置，其特征在于：所述端部形状为内凹的曲面。
  5. 根据权利要求1-4中任意一项所述的超声波振动装置，其特征在于：所述振动杆和/或固定件的一端具有凹槽，所述弹性体的一端处于该凹槽内。
  6. 液体混合系统，所述液体混合系统包括混合池和搅拌子；其特征在于：所述液体混合系统还包括：
    振动单元，所述振动单元采用权利要求1-5任一所述的超声波振动装置，并设置在所述混合池的下侧；所述振动杆的端部抵住所述混合池的底端。
  7. 根据权利要求6所述的液体混合系统，其特征在于：自上而下地，所述混合池的内径变小；所述混合池的底端为外凸的曲面，所述振动杆的顶端为内凹的曲面，与所述外凸的曲面匹配。
  8. 根据权利要求6或7所述的液体混合系统，其特征在于：所述液体混合系统还包括：
    温控单元，所述温控单元套在所述混合池外，内壁与所述混合池的外壁匹配，加热体设置在所述温控单元内。
  9. 根据权利要求8所述的液体混合系统，其特征在于：所述温控单元还包括：
    TEC制冷器，所述制冷器的冷端贴着所述温控单元，热端贴着散热器；
    风扇，所述风扇产生的气流吹扫所述散热器。
  10. 根据权利要求6-9中任意一项所述的液体混合系统，其特征在于：所述搅拌子为磁珠。
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