WO2021244676A1

WO2021244676A1 - Novel composition for enamel remineralization

Info

Publication number: WO2021244676A1
Application number: PCT/CN2021/109928
Authority: WO
Inventors: 王音特; 杨骁�; 孙亨; 周立文
Original assignee: 艾博莱特（苏州）科技有限公司
Priority date: 2020-06-02
Filing date: 2021-07-31
Publication date: 2021-12-09
Also published as: CN111700810A

Abstract

A novel composition for enamel remineralization. The composition is viscous paste. Components of the composition mainly comprise a nanometer compound, and the nanometer compound contains amorphous phosphate, an amphoteric high-molecular surfactant and β-tricalcium phosphate, wherein the amorphous phosphate is selected from amorphous calcium phosphate, amorphous fluorinated calcium phosphate or combinations thereof. The viscous paste as a linking agent or a binder can enable nanoscale ACP-APS or/and ACFP-APS and β-TCP to be adhered onto the surfaces of teeth, and then calcium in the dental enamel can be chemically bonded with the nanoscale ACP-APS or/and ACFP-APS and β-TCP compounds, so as to allow more remineralization components to be released in the oral cavity in a controlled manner. Also disclosed in the present invention is a use method of the composition.

Description

Novel composition for remineralizing tooth enamel

Technical field

The present invention relates to a composition, which is mainly composed of amorphous calcium phosphate (ACP) and/or amorphous calcium fluoride phosphate (ACFP), β-tricalcium phosphate (β-TCP) and an amphoteric polymer as a remineralizing agent It is composed of a nanocomposite formed by the association or combination of surfactants (APS) and a viscous paste containing hydrophobic anionic polymers. It also includes the combination of the composition and an orthodontic appliance. When a subject wears the appliance, the sustained release and remineralization can also be carried out.

Background technique

Excessive demineralization of tooth hard tissues can lead to caries damage and promote the remineralization of demineralized tooth enamel, which is one of the important methods to prevent and treat early caries. On the surface of tooth enamel, calcium ions and phosphate ions are in a state of dynamic equilibrium: when the pH value of the local microenvironment of tooth enamel drops, the hydroxyapatite (HA) crystals in hard tissues are dissolved and destroyed; when the concentration of calcium ions and phosphate ions is higher At high levels, minerals will re-precipitate, crystallize and remineralize, forming HA crystals.

The ratio between remineralization and demineralization determines the hardness and strength of the tooth structure. When the demineralization rate exceeds the remineralization rate, caries white spots and cavities usually appear after months or years. The remineralization of tooth enamel refers to the process of providing calcium and phosphate ions from sources outside the tooth structure to restore the mineral ions in the demineralized tooth enamel. A series of remineralization methods based on calcium phosphate have been developed for clinical application. One technology is bioglass containing calcium sodium phosphate (NOVAMINTM), the second is unstabilized amorphous calcium phosphate (ACP, ENAMELONTM), and the third is stable amorphous calcium phosphate containing casein titanium phosphate ( CPP-ACP; RECALDENTTM).

Amorphous calcium phosphate (ACP) compounds are an ideal source of calcium phosphate ions due to their high solubility. Amorphous calcium phosphate (ACP) is an unstable calcium phosphate system that has been developed and commercialized. U.S. Patent 5,427,768 (cited here as a whole) discloses a calcium phosphate solution that is supersaturated with respect to calcium carbonate solids and carbon dioxide. The solution deposits fluorine-containing or non-fluorine-containing calcium phosphate compounds on tooth defects, such as caries, exposed roots or dentin. U.S. Patent Nos. 5,037,639 and 5,268,167 (each of which are cited herein as a whole) discloses the use of amorphous calcium compounds, such as amorphous calcium phosphate (ACP), amorphous calcium fluoride phosphate (ACFP), amorphous calcium carbonate phosphate (ACCP) ) Carry out mineralization, fluorination and calcification of the organization. Amorphous calcium phosphate is added to Arm&Hammer's enamel care toothpaste, Discus Dental's Nite White bleaching gel, and Premier Dental's professional enamel polishing paste. In order to prevent the calcium ion and phosphate from reacting with each other before use, the above-mentioned products are stored in a double-pipe system or a low-moisture active carrier.

However, the ACP compound is unstable when it comes into contact with saliva in the oral environment, and will quickly transform into a stable crystalline state, with low solubility, and therefore poor bioavailability. Insoluble calcium phosphate is not easy to be applied. It cannot effectively accumulate on the tooth surface and requires acid dissolution to generate ions that can diffuse to the damage on the lower surface of the tooth enamel. On the other hand, due to the inherent insolubility of calcium phosphate, especially calcium fluoride phosphate, soluble calcium and phosphate ions can only be used at very low concentrations. The soluble calcium and phosphate ions basically do not penetrate into the dental plaque, nor do they collect on the surface of the tooth to generate an effective concentration gradient to drive the diffusion of the ions to the lower surface of the tooth enamel. The clinical use of remineralization of calcium and phosphate ions has not been successful in the past. The remineralization effect of ACP/ACFP is still questionable, because ACP/ACFP is transformed into an insoluble phase in saliva, and this may also cause dental calculus . In recent years, several methods have been developed to enhance the remineralization of ACP/ACFP in tooth enamel.

Casein is the main protein group found in milk, accounting for about 80% of the total protein. The casein titanium phosphate (CPP) obtained by trypsin digestion has been proven to stabilize amorphous calcium phosphate (ACP) and amorphous calcium fluoride phosphate (ACFP) by binding calcium ions and phosphate ion clusters on the calcium surface. Prevent calcium and phosphate ion clusters from growing to the critical size of the crystal nucleus shape and then undergo a phase change. Reynolds et al. applied for CPP-stabilized ACP complex (CPP-ACP) and CPP-stabilized ACFP complex (CPP- ACFP) patent. A lot of scientific evidence shows that CPP-ACP and CPP-ACFP can promote the remineralization of the subsurface damage of tooth enamel and prevent demineralization, because these compounds provide a high concentration of biologically acceptable source of calcium and phosphate ions, and these ions Can spread into tooth enamel. In addition, they can also bind to the surface of dental calculus to prevent or reduce further growth. Commercially available Trident Xtra Care sugar-free chewing gum, Recaldent tooth protector (Tooth Mousse and Tooth Mousse Plus, MI Paste and MI Paste Plus) all add these compounds. However, because casein can cause milk protein allergy, the use of CPP-ACP/CPP-ACFP is still limited.

On the other hand, a new type of remineralization material based on tricalcium phosphate (TCP) gives a special form of phosphate, which can significantly increase the bioavailability of calcium and phosphate ions in the local oral environment, thereby enhancing Remineralization effect.

TCP is a synthetic inorganic biological material with good biocompatibility and biological activity, and has the property of promoting the remineralization of tooth enamel. It is also often used to repair damaged bone tissue. TCP usually exists in two forms, namely α-TCP and β-TCP, in which β-TCP has low solubility, and β-TCP is often regarded as typical in the oral cavity due to its excellent osteoconductivity and bioabsorbability. Bone substitutes are used in various bone regeneration techniques and have achieved good results. β-TCP has not been reported in the existing clinical treatment in the field of preventing dental tissue demineralization. Some experts have confirmed through in vitro genotoxicity studies that β-TCP has no toxic effect on human peripheral blood cultures in vitro, and no toxic reaction occurs even when the dosage reaches the highest concentration, indicating that β-TCP has better biological safety.

β-TCP is a calcium phosphate system that exhibits crystal-modified structural defects in structure, which can promote the combination with other substances. Therefore, although TCP can effectively increase the calcium content in the surface of demineralized enamel and saliva, when fluoride ions are present in the oral environment, early reactions between calcium ions and fluoride ions in calcium phosphate are prone to occur, which will lead to bioavailable fluoride ions. Loss. In order to solve the problem of incompatibility between calcium phosphate and fluoride ions, TCP must be processed and activated to form functionalized β-tricalcium phosphate (fTCP). fTCP is a material obtained by coupling β-TCP with organic and/or inorganic moieties (such as surfactants such as carboxylic acid and fumaric acid). After TCP interacts with organic materials, the calcium phosphate in it is protected by the organic materials, so that the calcium ions, phosphate ions and fluoride ions of TCP can coexist in a water-soluble environment, which prevents the early interaction between these ions and fluoride. When the TCP component reaches the tooth surface, the affinity organic material on the tooth surface forms a barrier. When it comes into contact with saliva, it ruptures and releases calcium ions. This surfactant brings calcium ions to the tooth surface and combines with fluoride ions. Increase the bioavailability of fluoride and calcium on the surface of the lesion, and then diffuse to the lesion to promote remineralization. This reaction process also creates opportunities for remineralization of the enamel below the surface. Compared with the effect of pure fluoride, fTCP helps to increase the number of P-O bonds and P-F bonds, and improve the remineralization ability of fluoride. fTCP can also deliver calcium and phosphate to the enamel, thereby increasing the deposition of organic matter on the enamel surface and promoting remineralization. Due to the addition of TCP, the remineralization effect of fluoride is not limited, and the demineralization prevention effect is synergistically enhanced.

Summary of the invention

The purpose of the present invention is to provide a novel composition for remineralizing tooth enamel.

In order to achieve the above objective, the technical solution adopted by the present invention is:

A new type of composition for remineralizing tooth enamel. The composition is a viscous paste, and its composition mainly includes a nanocomposite containing amorphous phosphate and amphoteric polymer surfactants And β-tricalcium phosphate; wherein the amorphous phosphate is selected from amorphous calcium phosphate, amorphous calcium fluoride phosphate or a combination thereof.

The relevant content in the above technical solution is explained as follows:

1. In the above solution, a viscous paste is also included.

2. In the above solution, the viscous paste contains a hydrophobic anionic polymer.

The viscous paste is used to combine the calcium ions in the nanocomposite with the calcium in the tooth enamel, so as to achieve the sustained release of ACP and/or ACFP and β-TCP within a limited period of time.

3. In the above scheme, the composition contains a hydrophobic anionic polymer in a weight ratio of 0.2-2%.

4. In the above solution, the water content of the composition is less than 15% (weight ratio), and it is most preferable that the water content is less than 5% (weight ratio).

5. In the above scheme, the composition contains a desensitizer selected from potassium nitrate, sodium citrate, calcium nitrate, potassium hydroxide, magnesium hydroxide, sodium chloride, calcium phosphate, silver nitrate , Sodium citrate or a combination thereof.

6. In the above solution, the composition contains an evaporable temporary solvent. The temporary solvent is preferably ethanol or propanol. The temporary solvent is used to dissolve the hydrophobic anionic polymer, and the polymer is preferably polylactic acid.

7. In the above solution, the composition contains a thickener selected from carrageenan, carboxyvinyl polymer, hydroxyethyl cellulose, clay, karaya gum, xanthan gum, gum arabic , Tragacanth gum, colloidal magnesium aluminum silicate, silicon dioxide or a combination thereof.

8. In the above solution, the composition contains a liquid dispersant selected from glycerin, propylene glycol, polyethylene glycol or a combination thereof. The polyethylene glycol can be PEG200, PEG400, PEG600.

9. In the above solution, the composition contains a fluoride selected from sodium fluoride, stannous fluoride or a combination thereof.

10. In the above solution, the composition contains a chelating copolymer to stabilize the fluoride, and the fluoride is selected from alkyl vinyl ether, maleic anhydride or a combination thereof.

In order to achieve the above objective, another technical solution adopted by the present invention is:

A method of applying a composition that remineralizes tooth enamel to an orthodontic appliance during orthodontics, including:

Apply a layer of composition that remineralizes tooth enamel before wearing the orthodontic appliance; or directly add the composition to the orthodontic appliance before wearing the appliance;

After the treatment, remove the orthodontic appliance and rinse with water to remove the residual tooth remineralization composition in the orthodontic appliance;

The composition is a viscous paste, and its ingredients mainly include a nanocomposite, which contains an amorphous phosphate, an amphoteric polymer surfactant and β-tricalcium phosphate; wherein the amorphous The phosphate is selected from amorphous calcium phosphate, amorphous calcium fluoride phosphate, or a combination thereof.

The relevant content in the above technical solution is explained as follows:

1. In the above scheme, the orthodontic appliance is a device for treating malocclusion.

2. In the above solution, the composition is applied to the surface of the tooth from the orthodontic appliance during orthodontic treatment.

3. In the above-mentioned solution, the time that the composition stays on the tooth surface is limited, so during the orthodontic treatment, the orthodontic appliance is used to maintain its continuous remineralization.

4. In the above scheme, the application method is performed every time the orthodontic appliance is put on or taken off.

5. In the above solution, the composition further includes a viscous paste.

6. In the above solution, the viscous paste contains a hydrophobic anionic polymer.

The above technical solutions are further explained as follows:

The present invention relates to a composition, which is mainly composed of amorphous calcium phosphate (ACP) and/or amorphous calcium fluoride phosphate (ACFP), β-tricalcium phosphate (β-TCP) and an amphoteric polymer as a remineralizing agent The nanocomposite formed by the association or combination of surfactant (APS) and a viscous paste containing hydrophobic anionic polymer.

The invention can be applied to oral care for remineralization of tooth enamel.

In an embodiment, a composition for remineralizing tooth enamel is disclosed, wherein the composition is a viscous paste containing a nanocomposite, the nanocomposite containing an amorphous phosphate, an amphoteric polymer Surfactant and β-tricalcium phosphate, wherein the amorphous phosphate is selected from amorphous calcium phosphate (ACP), amorphous calcium fluoride phosphate (ACFP) or a combination thereof.

In related aspects, the composition further comprises a viscous paste. Specifically, the viscous paste contains a hydrophobic anionic polymer. On the other hand, the hydrophobic anionic polymer contains polylactic acid (PLA). The β-TCP is coupled with an amphoteric polymer surfactant to obtain functionalized β-tricalcium phosphate (fTCP).

In one aspect, the hydrophobic anionic polymer is preferably polylactic acid (PLA). High-molecular-weight PLA can be degraded in the human body. The body erosion mechanism is considered to be the main way of degradation of PLA and PLGA, and the hydrolysis of the ester bond on the polymer chain is the root cause. Studies have also shown that the terminal carboxyl groups (introduced and degraded by polymerization) in PLA polymers catalyze their hydrolysis. As the degradation progresses, the amount of terminal carboxyl groups increases and the degradation speeds up, which is the so-called autocatalysis phenomenon. The final degradation products of PLA are lactic acid that can be metabolized by living cells.

On the one hand, the viscous paste combines the calcium in the tooth enamel with the calcium ions in the nanocomposite, thereby achieving sustained release of ACP and/or ACFP and β-TCP within a limited period of time.

On the other hand, the hydrophobic anionic polymer accounts for 0.2% to 2% of the total weight of the composition.

On the one hand, the water content of the composition is less than 15% (weight ratio), and it is most preferred that the water content is less than 5% (weight ratio). In another aspect, the composition contains a desensitizer selected from potassium nitrate, sodium citrate, calcium nitrate, potassium hydroxide, magnesium hydroxide, sodium chloride, calcium phosphate, silver nitrate or a combination thereof.

On the other hand, the composition contains selected from carrageenan, carboxyvinyl polymer, hydroxyethyl cellulose (HEC), (natural and synthetic) clay, karaya, xanthan gum, acacia, tragacanth, Thickener for colloidal magnesium aluminum silicate, (finely divided) silicon dioxide, or a combination thereof.

In one aspect, the composition contains a liquid dispersant selected from glycerin, propylene glycol, polyethylene glycol (PEG200, PEG400, PEG600) or a combination thereof.

In the embodiment, a method for applying a composition that remineralizes enamel to an orthodontic appliance during orthodontics is disclosed, which includes: applying a layer to the tooth surface before wearing the orthodontic appliance. Enamel remineralization composition; or directly add the composition to the orthodontic appliance before wearing the appliance; after the treatment, remove the orthodontic appliance and wash away the residual teeth in the orthodontic appliance with water. Remineralization化Composition.

In a related aspect, in orthodontic treatment, the remineralizing composition is applied to the surface of the teeth in the orthodontic appliance.

On the one hand, the time that the remineralizing composition stays on the tooth surface is limited, so it is passed through an orthodontic appliance during orthodontic treatment to maintain its continuous remineralization.

On the other hand, the application method is performed every time the orthodontic appliance is put on or taken off.

In one aspect, the composition also includes a viscous paste.

In a related aspect, the viscous paste comprises a hydrophobic anionic polymer.

Specifically, the molecular weight of amphoteric polymer surfactants (APS) is between 500 and 500,000 kDa.

The present invention provides a composition, including a nanocomposite, the nanocomposite is mainly composed of an amorphous phosphate selected from the group consisting of amorphous calcium phosphate (ACP), amorphous calcium fluoride phosphate (ACFP) or a combination of both, It is composed of β-tricalcium phosphate (β-TCP) and amphoteric polymer surfactant. Due to the use of amphoteric polymer surfactants as nanocarriers for ACP and TCP, the composition does not have potential milk protein allergies. In an aqueous solution, the amphoteric polymer surfactant forms a nano-component of a micelle structure composed of a hydrophobic core, which is surrounded by a hydrophilic macromolecular shell. APS micelles act as a nano-dispersant that prevents the aggregation of ACP and/or ACFP and TCP and a nano-carrier that promotes the combination or association of polymers with ACP and/or ACFP and TCP. Therefore, they can stabilize ACP and/or ACFP and TCP. It is not transformed into a crystalline form.

detailed description

The present invention will be further described below in conjunction with embodiments:

Examples: Before describing the composition, method, and methodology of the present invention, it should be understood that the present invention is not limited to the specific composition, method, and experimental conditions, as such compositions, methods, and conditions can vary. It should also be understood that the terms used herein are only for describing specific embodiments, not for limitation, because the scope of the present invention is limited only in the appended claims.

As used in this specification and appended claims, unless the context clearly dictates otherwise, the singular forms "a", "an" and "such" include plural references. Therefore, for example: when referring to "nucleic acid", it includes one or more nucleic acids, and/or the type of composition described herein, which is useful to those skilled in the art reading this disclosure or the like Obvious.

Unless otherwise defined, all technical and scientific terms used herein are the same as understood by those of ordinary skill in the art to which the present invention belongs. Any methods and materials similar or equivalent to those described herein can be used in the practice and testing of the present invention, which can be understood because the spirit and scope of the present invention include modifications and changes.

As used herein, "approximately", "approximately", "substantially", "obviously", those of ordinary skill in the art can understand these words, but their meanings will be different to some extent according to the context in which they are used. If a person of ordinary skill in the art is not clear about the use of terms in the article, "about" and "approximately" mean less than the addition or subtraction of the specific term by 10%, and "substantially" and "obviously" mean more than the addition or subtraction of the specific term. 10%. In the embodiments, the composition may "comprise", "include" or "essentially consist of a specific component of a set of components", and the skilled artisan will understand that the latter means specific materials within the scope of the claims. And steps, these will not substantially affect the basic and novel features of the invention.

As used herein, "sticky" means glue-like texture-sticky. For example, the viscous paste may contain negatively charged polymers (hydrophobic anionic polymers), abrasive silica, nano-sized silica, or a combination thereof.

Nano-scale silica is preferred, and the size of the nanoparticles reaches 194nm, which can enter and fill the dentin tubules (2-4 microns).

The composition of the present invention is mainly composed of amorphous phosphate, β-tricalcium phosphate (β-TCP) and amphoteric polymer surfactants associating or complexing with amorphous calcium phosphate, amorphous calcium fluoride phosphate or a combination thereof It is composed of nanocomposite and viscous paste. By associating or complexing with amphoteric polymer surfactants, ACP and/or ACFP can maintain stability to prevent conversion into crystalline apatite. TCP's calcium ion and phosphate ion and fluoride ion can also coexist in a water-soluble environment , And then the bioadhesive can be combined with ACP and/or ACFP, β-TCP on the tooth surface, so the enamel remineralization of ACP and/or ACFP, β-TCP is enhanced.

"Amphoteric polymer" refers to molecules that can both attract and repel water. Amphoteric polymer surfactants contain two parts, hydrophilic and hydrophobic. Since amphoteric polymers can reduce surface tension, they are generally used as surfactants. "Amphoteric polymer" and "amphoteric polymer surfactant" can be used interchangeably in the present invention.

The association or combination of ACP and/or ACFP and β-TCP with amphoteric polymers as nanocarriers can further stabilize ACP and/or ACFP to prevent conversion to crystalline apatite. At the same time, the calcium ions and phosphate ions of TCP are combined with Fluoride ions can also coexist in a water-soluble environment, so the remineralization of tooth enamel is enhanced. Based on the above-mentioned mechanism, the ideal requirement for dispersants is to have the ability to stabilize ACP and/or ACFP and prevent them from agglomerating into large particles and transforming into a crystalline form. In addition, the viscous paste can be used as a connecting agent or adhesive to attach nano-level ACP or ACFP and β-TCP to the surface of the tooth, and combine nano-level ACP-APS or ACFP-APS and β-TCP-APS composite The calcium ions in the enamel chemically bond with the calcium in the tooth enamel, so that ACP and/or ACFP and β-TCP can be released from the composition continuously over time, including those that may be combined with, for example, orthodontic appliances. In this case, when a subject wears the appliance, the above-mentioned continuous release and remineralization can also be carried out.

Other devices that may be used with the composition, such as, but not limited to, toothbrushes, tongue scrapers, dental floss, toothpicks, mouth guards, and orthodontic devices, such as brackets and retainers. The appliances used in the oral cavity are not limited to cleaning and orthodontic devices. Other devices include objects designed to be used in the oral cavity, such as pacifiers and chew toys for toddlers and babies, such as rubber rings.

Such a device can be combined with the composition of the present invention. When the surface of the device is exposed in the oral cavity, the composition on the surface of the device will be released into the oral cavity.

Adding the composition directly to the device can also be done through porous materials. The device can be made of porous material or coated with it. Generally, this material contains pores into which the composition can be accommodated. When the device is used, for example in the oral cavity, the composition is released. If the pores release the composition contained therein, the porous material can be exposed to the composition to fill the pores to treat the porous material. Thus, the composition can be released through the pores, or can enter the pores.

Amphoteric polymers meet the above requirements. Moreover, amphoteric polymer surfactants (APS) can prevent ACP and/or ACFP from agglomerating into large particles, stabilize ACP and/or ACFP, prevent conversion to a stable crystalline form, and can enhance ACP and/or ACFP molecules and amphoteric high The binding or association of molecular surfactants.

At the same time, amphoteric polymer surfactants (APS) enable TCP’s calcium ions, phosphate ions, and fluoride ions to coexist in a water-soluble environment, which prevents the early interaction between these ions and fluoride. When the TCP component reaches the tooth surface, the tooth The organic material with affinity on the surface forms a barrier. When it comes into contact with saliva, it breaks and releases calcium ions. This surfactant brings calcium ions to the tooth surface and binds to fluoride ions, thereby increasing the fluoride and calcium on the surface of the disease. The bioavailability of it, then spread to the lesion to promote remineralization.

On the other hand, APS is selected from non-ionic polymer surfactants and ionic polymer surfactants, and combinations of both. Non-ionic polymer surfactants include (but are not limited to) diblock polyethylene oxide and polypropylene oxide (PEO-PPO) copolymers (PPO is the hydrophobic block and PEO is the hydrophilic block); diblock polycyclic Ethylene oxide and polybutylene oxide copolymer (PEO-PBO) (using PBO as the hydrophobic block and PEO as the hydrophilic block); triblock PEO-PPO-PEO copolymer; triblock PEO-PBO- PEO copolymer and so on. The ionic surfactant is selected from (but not limited to) polyalkylene acrylic acid, polyalkylene maleic anhydride, polyalkylene polyacrylic acid, polyalkylene maleic acid, polyalkylene sulfonic acid maleic acid , And polystyrene acrylic acid, polystyrene maleic anhydride, polystyrene polyacrylic acid, polystyrene maleic acid, polystyrene sulfonic acid maleic acid. The ionic surfactant can also be a polycationic polymer, such as polyalkylene polyamine, polystyrene polyamine, copolymer composed of cationic polyamine, chitosan and its derivatives.

On the other hand, the molecular weight of APS is between 500 and 500,000 kDa.

As mentioned above, the disclosed composition includes a viscous paste, more specifically, a viscous paste including a hydrophobic anionic polymer. In an embodiment, the hydrophobic anionic polymer may be polylactic acid (PLA).

In the embodiment, at least one optional desensitizer is contained, including potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate, strontium salt or mixtures thereof.

The following examples will further describe the present invention, but at the same time do not constitute any restriction on it.

Example 1. Remineralized paste composition 1

Example 2. Remineralized paste composition 2

The water content in the paste is less than 2%. The viscosity was measured with a Brookfield rheometer. The viscosity is between 5000 centipoise and 20000 centipoise (cps).

It should be understood that the above-mentioned composition or formulation is only an example of the type of formulation. The scope of the invention disclosed and defined is all alternative combinations of two or more individual features mentioned or obvious in the text. All combinations constitute various optional points of the present invention.

The above-mentioned embodiments are only to illustrate the technical concept and characteristics of the present invention, and their purpose is to enable those familiar with the technology to understand the content of the present invention and implement them accordingly, and cannot limit the protection scope of the present invention. All equivalent changes or modifications made in accordance with the spirit of the present invention should be covered by the protection scope of the present invention.

Claims

A novel composition for remineralizing tooth enamel, which is characterized in that: the composition is a viscous paste, and its ingredients mainly include a nanocomposite, which contains amorphous phosphate, amphoteric high Molecular surfactants and β-tricalcium phosphate; wherein the amorphous phosphate is selected from amorphous calcium phosphate, amorphous calcium fluoride phosphate or a combination thereof.
The composition of claim 1, further comprising a viscous paste.
The composition of claim 2, wherein the viscous paste contains a hydrophobic anionic polymer.
The composition according to claim 2, wherein the composition contains a hydrophobic anionic polymer in a weight ratio of 0.2-2%.
The composition according to claim 1, wherein the water content of the composition is less than 15%.
The composition according to claim 1, wherein the composition contains a desensitizer selected from potassium nitrate, sodium citrate, calcium nitrate, potassium hydroxide, magnesium hydroxide, chlorine Sodium phosphate, calcium phosphate, silver nitrate, sodium citrate or a combination thereof.
The composition according to claim 1, wherein the composition contains a thickener selected from the group consisting of carrageenan, carboxyvinyl polymer, hydroxyethyl cellulose, clay, karaya Gum, xanthan gum, acacia gum, tragacanth gum, colloidal magnesium aluminum silicate, silicon dioxide, or a combination thereof.
The composition according to claim 1, wherein the composition contains a liquid dispersant selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, or a combination thereof.
The composition according to claim 1, wherein the composition contains a fluoride selected from sodium fluoride, stannous fluoride or a combination thereof.
The composition according to claim 1, wherein the composition contains a chelating copolymer to stabilize the fluoride, and the fluoride is selected from the group consisting of alkyl vinyl ether, maleic anhydride or a combination thereof.
A method for applying a composition for remineralizing tooth enamel to an orthodontic appliance during orthodontics, which is characterized in that it comprises:

Apply a layer of composition that remineralizes tooth enamel before wearing the orthodontic appliance; or directly add the composition to the orthodontic appliance before wearing the appliance;

After the treatment, remove the orthodontic appliance and rinse with water to remove the residual tooth remineralization composition in the orthodontic appliance;

The composition is a viscous paste, and its ingredients mainly include a nanocomposite, which contains an amorphous phosphate, an amphoteric polymer surfactant and β-tricalcium phosphate; wherein the amorphous The phosphate is selected from amorphous calcium phosphate, amorphous calcium fluoride phosphate, or a combination thereof.