WO2021237317A1

WO2021237317A1 - Antiperspirant composition, process for its production and use thereof

Info

Publication number: WO2021237317A1
Application number: PCT/BR2020/050189
Authority: WO
Inventors: Bruna Rodrigues SALOMAO; Pedro Tupinamba Werneck Barroso
Original assignee: L'oreal
Priority date: 2020-05-29
Filing date: 2020-05-29
Publication date: 2021-12-02
Also published as: FR3110841A1; FR3110841B1; BR112022016710A2

Abstract

Antiperspirant compositions, in particular antiperspirant clear compositions, preferably in the form of a gel, having good sensorial perception, being non-irritant to the skin, presenting high antiperspirant efficacy and leaving no residue. The compositions comprise an antiperspirant active agent selected from aluminium zirconium octachlorohydrate, aluminium zirconium pentachlorohydrate, aluminium zirconium tetrachlorohydrex GLY or aluminium zirconium trichlorohydrate or a mixture thereof, a non- ionic surfactant, steareth-100/PEG-136/HDI copolymer thickening agent and at least 70 wt% water. Preferred nonionic surfactant is PPG-26-buteth-26 and PEG-40 hydrogenated castor oil. The present invention also discloses a process of manufacturing the antiperspirant compositions and uses of the antiperspirant compositions.

Description

ANTIPERSPIRANT COMPOSITION, PROCESS FOR ITS PRODUCTION AND USE

THEREOF

FIELD OF THE INVENTION

The present disclosure is directed to antiperspirant compositions. More specifically, the present disclosure is directed to antiperspirant compositions, preferably in a form of a clear gel, having good sensorial perception, moisturizer, transparent, non-irritant to the skin, presenting high antiperspirant efficacy, and no residue, comprising an antiperspirant active agent, a surfactant and a thickening agent. The present invention also discloses a process of manufacturing the antiperspirant compositions and uses of the antiperspirant compositions.

BACKGROUND OF THE INVENTION

The armpits as well as certain other parts of the body (hands and feet) are generally the place of several discomforts, which can come directly, or not from the phenomena of perspiration. These phenomena often lead to uncomfortable sensations, which are mainly due to the presence of perspiration, which in some cases, make the skin moist and wet clothes, especially in the armpits or back, leaving visible traces and, also, unpleasant odors. Finally, during its evaporation, sweat can also leave salts and/or proteins on the surface of the skin, thus creating whitish traces on clothing. Such discomforts are observed even in the case of moderate perspiration.

In the field of cosmetics, it is well known to use, in topical application, antiperspirant products containing substances, which have the effect of limiting or even suppressing the flow of sweat in order to remedy the problems mentioned above. These products are generally available in the form of aerosol sprays, solids, sticks and roll-ons.

The antiperspirant active agents generally consist of salts or complexes of aluminum and/or zirconium, such as aluminum chloride and aluminum hydroxyhalides. These substances help to reduce the flow of sweat.

However, to achieve a satisfactory antiperspirant effect it is needed to use high concentrations of antiperspirant active agents. Such high concentration of antiperspirant active agents affects the stabilization of the antiperspirant composition, especially gel compositions, as well as can cause irritation to the skin.

Therefore, there has been a need for antiperspirant compositions in order to overcome the current drawbacks of the state of the art mentioned above. In view of this, the inventors surprisingly achieved new antiperspirant compositions in the form of clear gel, comprising high concentration of antiperspirant active agents, while preserving the sensory perception, high antiperspirant efficacy and good stability of the composition, transparency, and not being irritant to the skin. Such properties are achieved due to the specific combination of an antiperspirant active agent, a surfactant and a thickening agent of the present invention.

Particularly, the antiperspirant compositions according to the present invention show high antiperspirant efficacy, faster drying with no residue, long lasting fragrance, fresh sensation, and clean feel all day long. In addition, the composition of the invention presents a unique sensation, being softness and non-irritant to the skin.

SUMMARY OF THE INVENTION

The present disclosure relates to antiperspirant compositions in the form of a clear gel, presenting good sensorial perception, non-irritant to the skin, presenting good stability, high antiperspirant efficacy, faster drying and no residue, long lasting fragrance, fresh sensation, and clear feel all day long, comprising an antiperspirant active agent, a surfactant and a thickening agent. The present invention also discloses a process of manufacturing the antiperspirant compositions and uses of the antiperspirant compositions.

Other features and advantages of the present invention will be apparent from the following more detailed description of the desirable embodiments which illustrates, by way of example, the principles of the invention.

DETAILED DESCRIPTION OF THE INVENTION

The antiperspirant compositions of the present invention can comprise, consist of, or consist essentially of the essential elements and limitations of the present invention described herein, as well as any of the additional or optional ingredients, components, or limitations described herein.

The terms “a”, “an”, and “the” are understood to encompass the plural as well as the singular.

As used herein, the expression “at least one” means one or more and thus includes individual components as well as mixtures/combinations.

As used herein, the expression “clear gel”, means a transparent or translucent gel. More precisely, refers to an antiperspirant cosmetic composition having a transmittance of at least 80% at a wavelength of 600 nm, for example measured using a Lambda 40 UV-visible spectrometer. The compositions may have, e.g., a transmittance of at least 80%, at least 90%, or at least 95% at a wavelength of 600 nm, measured, e.g., using a Lambda 40 UV-visible spectrometer. The term "transparent” can also mean that an article is visible to the human eye when looking through the antiperspirant cosmetic composition contained in a clear glass bottle. All ranges and values disclosed herein are inclusive and combinable.

For examples, any value or point described herein that falls within a range described herein can serve as a minimum or maximum value to derive a sub-range, etc.

Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions are to be understood as being modified in all instances by the term “about” which can encompass +/- 10%, +/- 8%, +/- 6%, +/- 5%, +/- 4%, +/- 3%, +/- 2%, +/- 1%, or +/- 0.5%.

In an embodiment, the antiperspirant composition of the present invention comprises: (a) at least 10% of an antiperspirant active agent, selected from aluminum and zirconium salts, such as aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrex GLY , aluminum zirconium trichlorohydrate or a mixture thereof;

(b) at least 1.5% of a nonionic surfactant; (c) at least 0.5% of a thickening agent, selected from steareth-

100/PEG-136/HDI copolymer; and

(d) at least 70% of water.

All the amounts mentioned above are based on the total weight of the composition. Additionally, the antiperspirant compositions of the present invention may comprise one active compound selected from the group consisting of antiperspirant active agents, deodorant active agents and mixtures thereof.

In a further embodiment, the antiperspirant compositions of the present invention may comprise propylene glycol in a range of about 1 to about 15%, preferably in a range of about 5% to about 13% and even more preferably of about 7% to about 10% based on the total weight of the composition.

The compositions according to the present invention present good sensory perception, high antiperspirant efficacy and good stability, transparency, not being irritant to the skin, faster drying with no residue, long lasting fragrance, fresh sensation and clean feel all day long.

In a preferred embodiment, the amount of antiperspirant active agent in the antiperspirant composition of the present invention is from about 10% by weight to about 25% by weight, preferably from about 15% by weight to about 25% by weight, more preferably from about 20% by weight to 25% by weight, relative to the total weight of the composition.

The nonionic surfactant according to the antiperspirant composition of the present invention is preferably the PPG-26-buteth-26 (and) PEG-40 hydrogenated castor oil.

The amount of nonionic surfactant in the antiperspirant composition of the present invention is preferably from about 1.5% by weight to about 10% by weight, relative to the total weight of the composition, more preferably from about 2.5% by weight to about 8% by weight, even more preferably from about 2.8% by weight to about 7% by weight, relative to the total weight of the composition.

In a preferred embodiment, the antiperspirant composition of the present invention has an amount of the thickening agent of at least 0.5% weight to about 10% by weight, more preferably from about 1.0% by weight to about 7% by weight, even more preferably from about 2.5% by weight to about 5% by weight, relative to the total weight of the composition.

In a preferred embodiment, the antiperspirant composition comprises water in an amount of at least about 70% by weight, relative to the total weight of the composition, preferably from about 70% by weight to about 90% by weight, more preferably from about 75% by weight to about 85% by weight, even more preferably from about 75% by weight to about 80% by weight, relative to the total weight of the composition.

The antiperspirant composition of the invention can be used as a daily product for the skin. In a preferred embodiment, the antiperspirant composition of the present invention is in the form of a transparent gel, more precisely, a water clear gel composition.

In a further embodiment, the antiperspirant composition of the invention has a pH value ranging from 3.4 to 3.9. Additionally, the viscosity of the composition is from 750 cP to 2800 cP. In another preferred embodiment, the present invention is related to the use of the antiperspirant composition for manufacturing a product for reducing, masking or absorbing human unpleasant body odors and/or reducing the secretion of sweat, which can be used as antiperspirant daily product. In a further preferred embodiment, the product is in the form of a transparent gel, which is non-irritant to the skin.

A preferential example of a suitable antiperspirant composition according to the present invention comprises:

(a) 20% to 25% of an antiperspirant active agent selected from aluminum zirconium pentachlorohydrate or aluminum zirconium tetrachlorohydrex

GLY or a mixture thereof;

(b) 2% to 10% of a nonionic surfactant, selected from PPG-26- buteth-26 (and) PEG-40 hydrogenated castor oil;

(c) 1% to 10% of a thickening agent, selected from selected from steareth-100/PEG-136/HDI copolymer; and

(d) 70% to 90% of water; wherein the amounts are based on the total weight of the composition.

The present invention is also related to a process of manufacturing an antiperspirant composition that provides for the consumer the properties described above. The process according to the present invention can be prepared as follows:

(a) mixturing the water, steareth-100/PEG-136/HDI copolymer under agitation (600 rpm) during 5 min to 10 min;

(b) adding to the mixture of step (a), the PPG-26-Buteth-26 (and) PEG-40 Hydrogenated castor oil and the preservative, under agitation during 10 min to 15 min; optionally, adding the propylene glycol;

(c) adding to the mixture of step (b) the Zinc PCA + aluminum salt under agitation (600 rpm), during 3 min to 8 min.

ANTIPERSPIRANT ACTIVE AGENTS The term “antiperspirant active agent” is understood to mean any substance capable of reducing the secretion of sweat. Antiperspirant active agents may also act as deodorant active agents.

The antiperspirant active agents which can be used according to the invention are preferably chosen from aluminum salts; complexes of zirconium chlorohydrate and of aluminum chlorohydrate with an amino acid. In a preferred embodiment, the antiperspirant active agents are selected from the group consisting of aluminum salts.

Mention may in particular be made, among the aluminum salts, of aluminum chlorohydrate in the activated or nonactivated form, aluminum chlorohydrex, taluminum chlorohydrex polyethylene glycol complex, aluminum chlorohydrex propylene glycol complex, aluminum dichlorohydrate, aluminum dichlorohydrex polyethylene glycol complex, aluminum dichlorohydrex propylene glycol complex, aluminum sesquichlorohydrate, aluminum sesquichlorohydrex polyethylene glycol complex, aluminum sesquichlorohydrex propylene glycol complex, or aluminum sulphate buffered by sodium aluminum lactate.

Mention may in particular be made, among the aluminum and zirconium salts, of aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrate or aluminum zirconium trichlorohydrate.

The complexes of zirconium chlorohydrate and of aluminum chlorohydrate with an amino acid are generally known under the name ZAG (when the amino acid is glycine). They are disclosed in particular in Patent US 3,792,068. The ZAG complexes usually exhibit an Al/Zr quotient ranging from approximately 1.67 to 12.5 and a Metal/Cl quotient ranging from approximately 0.73 to 1.93.

Mention may be made, among these products, of the aluminum zirconium octachlorohydrexglycine, aluminum zirconium pentachlorohydrex glycine, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrex glycine and aluminum zirconium trichlorohydrex glycine complexes. In a preferred embodiment, the amount of antiperspirant active agent in the antiperspirant composition of the present invention is from about 10% by weight to about 25% by weight, preferably from about 15% by weight to about 25% by weight, more preferably from about 20% by weight to 25% by weight, relative to the total weight of the composition. SURFACTANTS

The antiperspirant composition according to the present invention comprises at least one surfactant, which is preferably selected from the group consisting of nonionic surfactants. Non-limiting examples of nonionic surfactants useful in the present invention include, for example, alkyl- and polyalkyl- esters of glycerol, polyglycerol ester of fatty acids, mixtures of alkyl- and polyalkyl- esters of glycerol with polyglyceryl, such as polyglyceryl-3 methylglucose distearate, oxyalkylenated (more particularly polyoxyethylenated), fatty acid esters of glycerol; oxyalkylenated fatty acid esters of sorbitan; oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty acid esters; oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty alcohol ethers; sugar esters, for instance sucrose stearate; fatty alcohol ethers of sugars, especially alkyl polyglucosides (APGs) such as decyl glucoside, lauryl glucoside, cetostearyl glucoside, optionally as a mixture with cetostearyl alcohol, and also arachidyl glucoside, for example in the form of a mixture of arachidyl alcohol, behenyl alcohol and arachidyl glucoside. According to one particular embodiment of the invention, the mixture of the alkyl polyglucoside as defined above with the corresponding fatty alcohol may be in the form of a self-emulsifying composition Mention may also be made of lecithins and derivatives (e.g. Biophilic), sugar esters and sodium stearoyl lactylate.

Oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty alcohol ethers are preferably those having a number of ethylene or propylene oxide (EO/PO) units ranging from 2 to 200. Mention may be made to steareth 40, steareth 100, beheneth 40 and beheneth 100.

Alkyl- esters of glycerol includes glyceryl esters of fatty acids, such as glyceryl stearate (glyceryl mono-, di-, and/or tristearate), glyceryl laurate or glyceryl ricinoleate, and mixtures thereof. As polyoxyalkylenated derivatives thereof, mono-, di-, or triester of fatty acids with a polyoxyalkylenated glycerol (mono, di-, or triester of fatty acids with a polyalkylene glycol ether of glycerol) can be cited, preferably polyoxyethylenated glyceryl stearate (mono-, di-, and/or tristearate), such as PEG-20 glyceryl stearate (mono-, di-, and/or tristearate).

Polyglycerol esters of fatty acids may be selected from the group consisting of esters derived from the reaction of polyglycerol having from 2 to 12 glycerol units, preferably from 3 to 10 glycerol units and of at least one fatty acid comprising from 8 to 24 carbon atoms, preferably from 8 to 20 carbon atoms, preferably from 10 to 18 carbon atoms and more preferably 10 to 14 carbon atoms. Fatty acids containing from 8 to 24 carbon atoms may be linear or branched, saturated or unsaturated. The fatty acids may be selected from the group consisting of oleic acid, stearic acid, isostearic acid, lauric acid, palmitic acid, myristic acid, linoleic acid, capric acid, caprylic acid, or mixtures thereof.

According to a preferred embodiment, polyglycerol esters of fatty acid are selected from esters derived from the reaction of polyglycerol comprising 2 to 12 glycerol units, preferably from 4 to 10 glycerol units, and of at least a fatty acid having less than 16 carbon atoms, preferably less than 15 carbon atoms, for example from 8 to 16 carbon atoms and better still from 8 to 14 carbon atoms.

According to one embodiment, the polyglycerol ester of fatty acid is selected from the group consisting of polyglycerol esters derived from the reaction comprising 4 to 10 glycerol units and of at least one fatty acid comprising from 8 to 12 carbon atoms preferably 10 to 12 carbon atoms such as lauric acid and / or capric acid. There may be mentioned for example the ester from polyglyceryl-10 reaction (glycerol homopolymer comprising 10 glycerol units) and lauric acid (INCI name: polyglyceryl-10 laurate) such as that marketed by the company Dr Straetmans under the DERMOFEEL reference G 10 L, the ester from the reaction polyglycerol-4 (glycerol homopolymer comprising 4 glycerol units) and capric acid (INCI name: polyglyceryl-4 caprate) such as that marketed by Evonik under the reference Tegosoft PC 41.

Examples of oxyalkylenated fatty acid esters that may be mentioned include the adducts of ethylene oxide with esters of lauric acid, palmitic acid, stearic acid or behenic acid, and mixtures thereof, especially those containing from 8 to 100 oxyethylene units, such as PEG-8 to PEG-50 laurate; PEG-8 to PEG-50 palmitate; PEG-8 to PEG-50 stearate; PEG-8 to PEG-50 distearate PEG-8 to PEG-50 palmitostearate; PEG-8 to PEG-50 behenate; polyethylene glycol 100 EO monostearate (PEG-100 stearate); and mixtures thereof.

Other examples of nonionic surfactants to be used in the surfactant system of the present invention include polycondensates of ethylene oxide and of propylene oxide of the structure below:

H-(0-CH2-CH2)a-(0-CH(CH₃)-CH2)b-(0-CH2-CH2)a-0H, in which a, a’ range from 2 to 150, and b ranges from 1 to 100.

In the chemical structure described above, preferably, a and a’ range from 10 to 130 and b ranges from 20 to 80, better still a and a’ range from 50 to 130 and b ranges from 30 to 80, and even better still a and a’ range from 80 to 130 and b ranges from 40 to 80. According to one particular embodiment, a and a’ are identical. The polycondensate of ethylene oxide and propylene oxide that is useful in the composition of the invention preferably has a weight-average molecular weight ranging from 250 to 19 000, better still ranging from 1200 to 15 000, in particular ranging from 1500 to 10 000 and even better still ranging from 1500 to 5000.

As polycondensate products of ethylene oxide and propylene oxide that may be used according to the invention, mention may be made of the polyethylene glycol/polypropylene glycol/polyethylene glycol triblock polycondensate products sold under the name Synperonic, for instance Synperonic® PE/F32 (INCI name: Poloxamer 108), Synperonic® PE/F108 (INCI name: Poloxamer 338), Synperonic® PE/L44 (INCI name: Poloxamer 124), Synperonic® PE/L42 (INCI name: Poloxamer 122), Synperonic® PE/F127 (INCI name: Poloxamer 407), Synperonic® PE/F88 (INCI name: Poloxamer 238), Synperonic® PE/L64 (INCI name: Poloxamer 184), Synperonic® PE/F88 (INCI name: Poloxamer 238), Synperonic® PE/F87 (INCI name: Poloxamer 237) by the company Croda, or Lutrol® F68 (INCI name: Poloxamer 188) by the company BASF.

In a preferred embodiment, the surfactant is a nonionic surfactant selected from PPG-26-buteth-26 (and) PEG-40 hydrogenated castor oil.

Preferably, the amount of the at least one nonionic surfactant in the anhydrous antiperspirant and deodorant composition of the present invention ranges from about 1.5% by weight to about 10% by weight, preferably from about 2.5% by weight to about 8% by weight, more preferably from about 2.8% by weight to about 7% by weight, based on the total weight of the composition.

THICKENING AGENTS The antiperspirant compositions according to the present disclosure may further comprise at least one thickening agent. Thickening agents are generally used to modify the viscosity and/or rheology of the antiperspirant cosmetic composition. As used herein, the term "thickening agent" means compounds which, by their presence, increase the viscosity of the antiperspirant cosmetic composition into which they are introduced by at least 20 cps, such as by at least 50 cps, at 25°C and at a shear rate of 1 s-1. The viscosity may be measured using a cone/plate viscometer, a Flaake R600 rheometer, or the like.

The thickening agent may be referred to interchangeably herein as thickener or rheology modifier. Thickening agents are also sometimes referred to as gellifying agents and/or viscosity modifying agents.

In certain embodiments, the thickening agent may be chosen from those conventionally used in cosmetics, such as polymers of natural origin and synthetic polymers, for example, nonionic, anionic, cationic, amphiphilic, or amphoteric polymers, and other known rheology modifiers, such as cellulose-based thickeners.

In certain embodiments, the thickening agents can be an anionic thickening agent.

The anionic thickening agents may be chosen from hydrophilic thickeners. As used herein, the term “hydrophilic thickener” is meant to indicate that the thickening agent is soluble or dispersible in water. Non-limiting examples of hydrophilic thickeners include homopolymers or copolymers of acrylic or methacrylic acids or the salts thereof and the esters thereof, such as those sold under the tradenames Versicol F® or Versicol K® by the company Allied Colloid, or under the tradename Ultrahold 8® by the company Ciba-Geigy; polyacrylates and polymethacrylates such as copolymers of (meth)acrylic acid, copolymers of (meth)acrylic acid, methylacrylate and dimethyl meta-isopropenyl benzyl isocyanate of ethoxylated alcohols such as methylacrylate and dimethyl meta-isopropenyl benzyl isocyanate of ethoxylated alcohol (INCI name: Polyacrylate-3) sold under the tradename Viscophobe® DB 1000 from The Dow Chemical Company, those sold under the tradenames Lubrajel and Norgel by the company Guardian, or under the tradename Hispajel by the company Hispano Chimica; and polyacrylic acids of Synthalen® K type, copolymers of acrylic acid and of acrylamide sold in the form of the sodium salt thereof, such as those sold under the tradenames Reten® by Hercules, sodium polymethacrylate such as those sold under the tradename

Darvan® 7 by the company Vanderbilt, and the sodium salts of polyhydroxycarboxylic acids such as those sold under the tradename Hydagen F® by the company Henkel, polyacrylic acid/alkyl acrylate copolymers of PemulenTM type, associative polymers, for instance PEG-150/stearyl alcohol/SMDI copolymer such those as sold under the tradename ACULYN™ 46 by the company Rohm & Haas, steareth-100/PEG-136/HDI copolymer such as those sold under the tradename Rheolate® FX 1100 by the company Elementis, and mixtures thereof.

As used herein, the term “copolymers” is intended to mean both copolymers obtained from two types of monomers and those obtained from more than two types of monomers, such as, for example, terpolymers obtained from three types of monomers. The chemical structure of the copolymers comprises at least one hydrophilic unit and at least one hydrophobic unit. The expression “hydrophobic unit” or “hydrophobic unit” is understood to mean a radical possessing a saturated or unsaturated and linear or branched hydrocarbon-based chain which comprises at least 8 carbon atoms, for example from 10 to 30 carbon atoms, as a further example from 12 to 30 carbon atoms, and as yet a further example from 18 to 30 carbon atoms.

In certain embodiments, the hydrophilic thickener may be chosen from anionic associative polymers. As used herein, the term “associative polymer” is intended to mean any polymer comprising in its structure at least one fatty chain and at least one hydrophilic portion.

In certain embodiments, the associative polymers may be chosen from polymers comprising at least one hydrophilic unit and at least one fatty-chain allyl ether unit; polymers in which the hydrophilic unit is constituted of an ethylenic unsaturated anionic monomer, such as a vinylcarboxylic acid, acrylic acid, methacrylic acid, or mixtures thereof; and polymers in which the fatty-chain allyl ether unit corresponds to the monomer of formula (I) below:

CM2 = C(R’)CH₂OBnR (I) in which R’ is chosen from H or CH3, B is an ethyleneoxy radical, n is zero or is chosen from an integer ranging from 1 to 100, and R is a hydrocarbon- based radical chosen from alkyl, arylalkyl, aryl, alkylaryl, or cycloalkyl radicals containing from 8 to 30 carbon atoms, from 10 to 24 carbon atoms, or from 12 to 18 carbon atoms. Exemplary and non-limiting polymers of this type are described and prepared, according to an emulsion polymerization process, in patent EP 0 216 479, incorporated by reference herein.

In certain embodiments, the associative anionic polymer may be chosen from anionic polymers comprising at least one hydrophilic unit of olefinic unsaturated carboxylic acid type, and at least one hydrophobic unit exclusively of (Cio-C3o)alkyl ester of unsaturated carboxylic acid type.

In certain embodiments, the at least one thickening agent is chosen from copolymers resulting from the polymerization of at least one monomer (a) chosen from carboxylic acids possessing a,b-ethylenically unsaturated groups or their esters, with at least one monomer (b) possessing ethylenically unsaturated groups and comprising a hydrophobic group. Such copolymers may exhibit emulsifying properties.

In certain embodiments, the thickening copolymer may be chosen from the copolymers resulting from the polymerization of: (1 ) at least one monomer of formula (II):

CH =CH(R1)C00H (II) wherein R1 is chosen from H, Chb, or C2H5, providing acrylic acid, methacrylic acid, or ethacrylic acid monomers, and

(2) at least one monomer of (C10 C3o)alkyl ester of unsaturated carboxylic acid type corresponding to the monomer of formula (III):

CH2=CH(R₂)COOR3 (III) wherein R2 is chosen from H, CH3, or C2H5, providing acrylate, methacrylate or ethacrylate units, and R3 denotes a C10 C30 alkyl radical, such as a C12 C22 alkyl radical. In certain embodiments, the (C10 C3o)alkyl esters of unsaturated carboxylic acids may be chosen from lauryl acrylate, stearyl acrylate, decyl acrylate, isodecyl acrylate, dodecyl acrylate or the corresponding methacrylates, such as lauryl methacrylate, stearyl methacrylate, decyl methacrylate, isodecyl methacrylate or dodecyl methacrylate, or mixtures thereof. In certain embodiments, the crosslinked thickening polymer may be chosen from polymers resulting from the polymerization of a mixture of monomers comprising:

(1) acrylic acid,

(2) an ester of formula (III) described above, in which R2 is chosen from H or CH3, R3 denotes an alkyl radical having from 12 to 22 carbon atoms, and

(3) a crosslinking agent, which is a known copolymerizable polyethylenic unsaturated monomer, such as diallyl phthalate, allyl (meth)acrylate, divinylbenzene, (poly)ethylene glycol dimethacrylate and methylenebisacrylamide. In various embodiments, the crosslinked thickening polymer may comprise from about 60% to about 95% by weight of acrylic acid (hydrophilic unit), from about 4% to about 40% by weight of C10 C30 alkyl acrylate (hydrophobic unit), and from about 0 % to about 6% by weight of crosslinking polymerizable monomer. In further embodiments, the crosslinked thickening polymer may comprise from about 96% to about 98% by weight of acrylic acid (hydrophilic unit), from about 1% to about

4% by weight of C10 C30 alkyl acrylate (hydrophobic unit), and from about 0.1% to 0.6% by weight of crosslinking polymerizable monomer, such as those described above.

In some embodiments, the crosslinked thickening polymer may be chosen from acrylate/Cio C30 alkyl acrylate copolymers (INCI name: Acrylates/C 10-30 Alkyl Acrylate Crosspolymer), such as the products sold under the tradenames Pemulen™ TR1, Pemulen™ TR2, Carbopol® 1382 and Carbopol® EDT 2020 by the company Lubrizol.

The anionic thickening agent may also be known as rheology modifiers such as acrylate- or acrylic-based polymers, carbomers, crosslinked homopolymers of acrylic acid or of acrylamidopropane-sulfonic acid, and crosslinked copolymers of (meth)acrylic acid and/or (Ci-C6)alkyl esters.

In an embodiment, the anionic thickening agent is chosen from polyacrylate-3, commercially known under the trade name of Viscophobe DB-100 and sold by The Dow Chemical Company, carbomers, commercially known under the trade name of Carbopol polymers and sold by Lubrizol Advance Materials, Inc, acrylates/Cio-3o alkyl acrylate crosspolymers, commercially known the trade names of Pemulen TR-1 and Pemulen TR-2 polymers and sold by Lubrizol Advance Materials, Inc, Acrylates/C 10-30 Alkyl Acrylate Crosspolymer such as Carbopol® Ultrez 20 Polymer by and sold by Lubrizol Advance Materials, Inc,, AMP-acrylates/allyl methacrylate copolymer, commercially known under the trade name of Fixate G-100 polymer and sold by Lubrizol Advance Materials, Inc., Polyacrylate Crosspolymer-6 such as SepimaxTM Zen by the company Seppic, and a crosslinked methacrylic acid/ethyl acrylate copolymer, also known as an acrylates copolymer in aqueous dispersion, such as the slightly cross-linked, alkali-swellable acrylate polymer known by the INCI name acrylates copolymer and sold by Lubrizol, under the tradename CARBOPOL Aqua SF-1 as an aqueous dispersion comprising about 30 percent by weight of total solids or active material. In various embodiments, the thickening agents may be chosen from hydrophilic thickeners, for example cellulose polymers and gums, modified or unmodified carboxyvinyl polymers, such as those sold under the tradename Carbopol® (CTFA name: carbomer) by the company Goodrich, polyacrylamides, copolymers of acrylic acid and of acrylamide sold in the form of the sodium salt thereof, such as those sold under the tradenames Reten® by Flercules, and the sodium salts of polyhydroxycarboxylic acids such as those sold under the tradename Flydagen F® by the company Flenkel, optionally crosslinked and/or neutralized 2- acrylamido-2-methylpropanesulphonic acid polymers and copolymers, for instance poly(2-acrylamido-2-methylpropanesulphonic acid) such as those sold under the tradename Hostacerin® AMPS (CTFA name: ammonium polyacryldimethyltauramide) by the company Clariant, crosslinked anionic copolymers of acrylamide and of AMPS, e.g. in the form of a water-in-oil emulsion, such as those sold under the tradename Sepigel™ 305 (CTFA name: Polyacrylamide/C13-14 lsoparaffin/Laureth-7) and under the tradename Simugel™ 600 (CTFA name: Acrylamide/Sodium acryloyldimethyltaurate copolymer/lsohexadecane/Polysorbate 80) by the company Seppic, polyacrylic acid/alkyl acrylate copolymers of PemulenTM type, associative polymers, for instance PEG-150/stearyl alcohol/SMDI copolymer such those as sold under the tradename ACULYN™ 46 by the company Rohm & Flaas, steareth-100/PEG-136/HDI copolymer such as those sold under the tradename Rheolate® FX 1100 by the company Elementis, and mixtures thereof.

In certain embodiments, the hydrophilic thickener may be chosen from associative polymers. As used herein, the term “associative polymer” is intended to mean any amphiphilic polymer comprising in its structure at least one fatty chain and at least one hydrophilic portion. As used herein, the term “amphiphilic polymer” means a polymer composed of hydrophilic and hydrophobic parts.

In certain embodiments, the associative polymers may be anionic, cationic, nonionic, or amphoteric. In certain embodiments, the associative polymers may be chosen from polymers comprising at least one hydrophilic unit and at least one fatty-chain allyl ether unit; polymers in which the hydrophilic unit is constituted of an ethylenic unsaturated anionic monomer, such as a vinylcarboxylic acid, acrylic acid, methacrylic acid, or mixtures thereof; and polymers in which the fatty-chain allyl ether unit corresponds to the monomer of formula (I) below: CH₂ = C(R’)CH₂OBnR (I) in which R’ is chosen from H or Chb, B is an ethyleneoxy radical, n is zero or is chosen from an integer ranging from 1 to 100, and R is a hydrocarbon- based radical chosen from alkyl, arylalkyl, aryl, alkylaryl, or cycloalkyl radicals containing from 8 to 30 carbon atoms, from 10 to 24 carbon atoms, or from 12 to 18 carbon atoms. Exemplary and non-limiting polymers of this type are described and prepared, according to an emulsion polymerization process, in patent EP 0 216 479, incorporated by reference herein.

In other embodiments, the associative cationic polymer may be chosen from quaternized cellulose derivatives and polyacrylates containing amine side groups.

In other embodiments, the non-ionic associative polymer may be chosen from celluloses modified with groups comprising at least one fatty chain, for instance hydroxyethyl celluloses modified with groups comprising at least one fatty chain, such as alkyl groups, e.g. Cs-C₂₂ alkyl groups, arylalkyl and alkylaryl groups; cetyl hydroxyethyl cellulose, also known under the tradename Natrosol® Plus (sold by the company Ashland), Bermocoll EHM 100 (sold by the company Berol Nobel), Amercell Polymer HM-1500® sold by the company Amerchol; hydroxyethylcellulose modified with a polyethylene glycol (15) nonylphenyl ether group, sold by the company Amerchol; celluloses modified with polyalkylene glycol alkylphenyl ether groups; guars such as hydroxypropyl guar, optionally modified with groups comprising at least one fatty chain such as an alkyl chain, for example Jaguar® XC- 95/3 (Ci4 alkyl chain, sold by the company Rhodia Chimie), Esaflor HM 22 (C₂₂ alkyl chain, sold by the company Lamberti), RE210-18 (Ci4 alkyl chain) and RE205-1 (C₂o alkyl chain, sold by the company Rhodia Chimie); copolymers of vinylpyrrolidone and of fatty-chain hydrophobic monomers, for instance Antaron® or Ganex® V216 (vinylpyrrolidone/hexadecene copolymers), Antaron® or Ganex® V220 (vinylpyrrolidone/eicosene copolymers) sold by the company I.S.P.; copolymers of Ci-Ce alkyl methacrylates, acrylates or amphiphilic monomers comprising at least one fatty chain; or copolymers of hydrophilic methacrylates, acrylates or hydrophobic monomers comprising at least one fatty chain, for instance the polyethylene glycol methacrylate/lauryl methacrylate copolymer.

Associative polyurethanes may also be chosen in various embodiments. As used herein, “associative polyurethanes” are nonionic block copolymers comprising in the chain both hydrophilic blocks usually of polyoxyethylene nature, and hydrophobic blocks that may be aliphatic sequences alone and/or cycloaliphatic and/or aromatic sequences. Associative polyurethanes comprise at least two hydrocarbon-based lipophilic chains containing from C6 to C30 carbon atoms, separated by a hydrophilic block, the hydrocarbon-based chains optionally being pendent chains or chains at the end of a hydrophilic block. For example, it is possible for one or more pendent chains to be provided. In addition, the polymer may comprise a hydrocarbon-based chain at one or both ends of a hydrophilic block. The associative polyurethanes may be arranged in triblock or multiblock form. The hydrophobic blocks may thus be at each end of the chain (for example, triblock copolymer with a hydrophilic central block) or distributed both at the ends and within the chain (for example, multiblock copolymer). These polymers may also be graft polymers or starburst polymers. In one embodiment, the associative polyurethanes may be triblock copolymers in which the hydrophilic block is a polyoxyethylene chain containing from 50 to 1000 oxyethylene groups. In other embodiments, associative polymers of the polyurethane polyether type that may be used include the polymer Ci6-OE120-Ci6 from Servo Delden (under the tradename SER AD FX1100), which is a molecule containing a urethane function and having a weight-average molecular weight of 1300, OE being an oxyethylene unit; Nuvis® FX 1100 (European and US INCI name "Steareth- 100/PEG-136/HMDI Copolymer" sold by the company Elementis Specialties); Acrysol

RM 184® (sold by the company Rohm and Flaas); Elfacos® T210® (C12-C14 alkyl chain); Elfacos® T212® (C18 alkyl chain) sold by the company Akzo; Rheolate® 205 containing a urea function, sold by the company Rheox; RFIEOLATE® 208 or 204, or RFIEOLATE® FX1100 sold by the company Elementis; or DW 1206B sold by the company Rohm & Flaas containing a C20 alkyl chain with a urethane bond, sold at a solids content of 20% in water.

In further embodiments, solutions or dispersions of these polymers, especially in water or in aqueous-alcoholic medium, may be chosen. Examples of such polymers include SER AD FX1010, SER AD FX1035, and SER AD 1070 from the company Servo Delden, and Rheolate® 255, Rheolate® 278, and Rheolate® 244 sold by Rheox. Further examples include the products Aculyn™ 46, DW 1206F, and DW 1206J, Acrysol RM 184 or Acrysol 44 from the company Rohm & Flaas, and Borchi® Gel LW 44 from the company Borchers. In further embodiments, the thickening agent may be chosen from nonionic homopolymers or copolymers containing ethylenically unsaturated monomers of the amide type, for example, the polyacrylamide products sold under the tradenames Cyanamer® P250 by the company CYTEC.

In further embodiments, the thickening agent chosen from polymers of natural origin may include thickening polymers comprising at least one sugar unit, for instance nonionic guar gums, optionally modified with C1-C6 hydroxyalkyl groups; biopolysaccharide gums of microbial origin, such as scleroglucan gum (also known as sclerotium gum) or xanthan gum; gums derived from plant exudates, such as gum arabic, ghatti gum, karaya gum, gum tragacanth, carrageenan gum, agar gum, carob gum, ceratonia siliqua gum or cyamopsis tetragonoloba (guar) gum; pectins; alginates; starches; hydroxy(Ci-C6)alkylcelluloses; or carboxy(Ci-C6)alkylcelluloses.

In certain embodiments, the nonionic, unmodified guar gums may be chosen from Guargel D/15 sold by the company Noveon, Vidogum GFI 175 sold by the company Unipectine, Meypro-Guar 50 sold by the company Meyhall, or Jaguar® C sold by the company Rhodia Chimie. In other embodiments, the nonionic modified guar gums may be chosen from Jaguar® HP8, FIP60, HP120, DC 293 and HP 105 sold by the companies Meyhall and Rhodia Chimie or GalactasolTM 4H4FD2 sold by the company Ashland.

In other embodiments, the thickening agents may be chosen from scleroglucans, for example, Actigum™ CS from Sanofi Bio Industries; Amigel® sold by the company Alban Muller International; xanthan gums, for instance Keltrol®, Keltrol® T, Keltrol® Tf, Keltrol® Bt, Keltrol® Rd, and Keltrol® Cg sold by the company CP Kelco, Rhodicare® S and Rhodicare® H sold by the company Rhodia Chimie; starch derivatives, for instance Primogel® sold by the company Avebe; hydroxyethylcelluloses such as Cellosize® QP3L, QP4400H, QP30000H,

HEC30000A and Polymer PCG10 sold by the company Amerchol, Natrosol™ 250HHR, 250MR, 250M, 250HHXR, 250HHX, 250HR, and 250 HX, sold by the company Hercules, or Tylose® H1000 sold by the company Hoechst; hydroxypropylcelluloses, for instance KlucelTM EF, H, LHF, MF, and G, sold by the company Ashland; carboxymethylcelluloses, for instance Blanose® 7M8/SF, refined 7M, 7LF, 7MF, 9M31 F, 12M31XP, 12M31 P, 9M31XF, 7H, 7M31 , and 7H3SXF, sold by the company Ashland, Aquasorb® A500 sold by the company Flercules, Ambergum® 1221 sold by the company Flercules, Cellogen® FIP810A and H P6FHS9 sold by the company Montello and Primellose® sold by the company Avebe.

In other embodiments, the modified nonionic guar gums may be modified, for example, with C1-C6 hydroxyalkyl groups. Such hydroxyalkyl groups may be chosen from hydroxymethyl, hydroxyethyl, hydroxypropyl, and hydroxybutyl groups. In certain embodiments, guar gums may be prepared by reacting the corresponding alkylene oxides, such as for example propylene oxides, with guar gum so as to obtain a guar gum modified with hydroxypropyl groups. The hydroxyalkylation ratio, which corresponds to the number of alkylene oxide molecules consumed to the number of free hydroxyl functional groups present on the guar gum, may in certain embodiments range from about 0.4 to about 1.2.

Examples of nonionic guar gums, optionally modified with hydroxyalkyl groups, include those sold under the tradenames Jaguar® HP8, Jaguar® FIP60, Jaguar® HP120, Jaguar® DC 293, and Jaguar® HP 105 by the company Rhodia Chimie, and under the tradename Galactasol™ 4FI4FD2 by the company Ashland. In other embodiments, the guar gum may be chosen from those modified with a quaternary ammonium group, such as guar hydroxypropyltrimonium chloride, also sold under the tradename Jaguar® C-13S by the company Rhodia Chimie.

In other embodiments, the celulloses may be chosen from hydroxyethylcelluloses and hydroxypropylcelluloses, such as those sold under the tradenames KlucelTM EF, KlucelTM H, KlucelTM LHF, KlucelTM MF, KlucelTM G, by the company Ashland and under the tradename CellosizeTM PCG-10 by the company Amerchol.

In other embodiments, non-limiting thickening polysaccharides may be chosen from glucans; modified or unmodified starches such as those derived, for example, from cereals such as wheat, corn or rice, vegetables such as golden pea, or tubers such as potato or cassava; amylose, amylopectin, glycogen, dextrans, celluloses or derivatives thereof (methylcelluloses, hydroxyalkylcelluloses, ethylhydroxyethylcelluloses), mannans, xylans, lignins, arabans, galactans, galacturonans, chitin, chitosans, glucoronoxylans, arabinoxylans, xyloglucans, glucomannans, pectic acids or pectins, arabinogalactans, carrageenans, agars, gums arabic, gums tragacanth, Ghatti gums, Karaya gums, carob gums, galactomannans such as guar gums and their nonionic derivatives such as hydroxypropylguar, or mixtures thereof.

In other embodiments, the thickening agent may be chosen from silicas or hydrophobic silicas, such as those described in EP-A-898960, incorporated by reference herein. Examples of such silicas include those sold under the tradename Aerosil® R812 by the company Degussa, CAB-O-SIL® TS-530, CAB-O-SIL® TS-610, CAB-O-SIL® TS-720 by the company Cabot, or Aerosil® R972 and Aerosil® R974 by the company Degussa; clays, such as montmorillonite; modified clays such as the bentones, for example, stearalkonium hectorite, stearalkonium bentonite; or polysaccharide alkyl ethers, optionally with the alkyl group having from 1 to 24 carbon atoms, for example from 1 to 10 carbon atoms, from 1 to 6 carbon atoms, or from 1 to 3 carbon atoms, such as those described in document EP-A-898958, incorporated by reference herein.

In certain embodiments, when an anionic thickening agent is used, it is generally neutralized before being included in, or as it is added to the antiperspirant cosmetic compositions of the disclosure. Such an anionic thickening agent may be neutralized by employing traditional neutralizing agents such as alkanolamines, for example, monoethanolamine and diethanolamine; aminomethyl propanol; basic amino acids, for example arginine and lysine; or ammonium compounds and their salts. The anionic thickening agent may also be neutralized by a latex polyurethane polymer having at least one free amino group. In one embodiment of the present invention, the at least one thickening agent is selected from cellulose polymers, gums, modified or unmodified carboxyvinyl polymers, polyacrylamides, copolymers of acrylic acid and of acrylamide, sodium salts of polyhydroxycarboxylic acids, optionally crosslinked and/or neutralized 2- acrylamido-2-methylpropanesulphonic acid polymers and copolymers, polyacrylic acid/alkyl acrylate, glucans, modified or unmodified starches, silicas, and mixtures thereof.

In preferred embodiment of the present invention, the thickening agent is selected from steareth-100/PEG-136/HDI copolymer. In one embodiment of the present invention, the thickening agent is present in an amount of at least 0.5% weight to about 10% by weight, more preferably from about 1% by weight to about 7% by weight, even more preferably from about 2.5% by weight to about 5% by weight, relative to the total weight of the composition, including all ranges and subranges therebetween.

WATER

The antiperspirant compositions according to the invention comprise water. The water used may be sterile demineralized water and/or deionized water and/or a floral water such as rose water, cornflower water, chamomile water or lime water, and/or a natural thermal or mineral water such as, for example: water from Vittel, water from the Vichy basin, water from Uriage, water from La Roche Posay, water from La Bourboule, water from Enghien-les-Bains, water from Saint Gervais- les-Bains, water from Neris-les-Bains, water from Allevar-les-Bains, water from Digne, water from Maizieres, water from Neyrac-les-Bains, water from Lons-le-Saunier, water from EauxBonnes, water from Rochefort, water from Saint Christau, water from Les Fumades, water from Tercis-les-Bains or water from Avene. Water may also comprise reconstituted thermal water, that is to say a water comprising trace elements such as zinc, copper, magnesium, etc., reconstituting the characteristics of a thermal water. The antiperspirant composition according to the invention may comprise water in an amount ranging from about 70% by weight, relative to the total weight of the composition, preferably from about 70% by weight to about 90% by weight, more preferably from about 75% by weight to about 85% by weight, even more preferably from about 75% by weight to about 80% by weight, relative to the total weight of the composition.

Deodorant active agents

The composition of the present invention may further comprises an “deodorant active agent”, which is any substance capable of reducing, masking or absorbing unpleasant human body odors, in particular underarm odors. If present in the composition, such deodorant active agent could be selected from bacteriostatic agents or bactericides that act on underarm odor microorganisms, such as 2,4,4'- trichloro-2'-hydroxydiphenyl ether (©Triclosan), 2,4-dichloro-2'-hydroxydiphenyl ether, 3’,4’,5’-trichlorosalicylanilide, 1-(3’,4’-dichlorophenyl)-3-(4’-chlorophenyl)urea

(©Triclocarban) or 3,7,11-trimethyldodeca-2,5,10-trienol (©Farnesol); quaternary ammonium salts such as cetyltrimethylammonium salts, cetylpyridinium salts, DPTA (1 ,3-diaminopropanetetraacetic acid), 1 ,2-decanediol (Symclariol from the company Symrise); glycerol derivatives, for instance caprylic/capric glycerides (Capmul MCM® from Abitec), glyceryl caprylate or caprate (Dermosoft GMCY® and Dermosoft GMC® from Straetmans), polyglyceryl-2 caprate (Dermosoft DGMC® from Straetmans), and biguanide derivatives, for instance polyhexamethylene biguanide salts; chlorhexidine and salts thereof; 4-phenyl-4,4-dimethyl-2-butanol (Symdeo MPP® from Symrise); zinc salts such as zinc salicylate, zinc gluconate, zinc pidolate, zinc sulfate, zinc chloride, zinc lactate or zinc phenolsulfonate; zinc PCA, salicylic acid and derivatives thereof such as 5-n-octanoylsalicylic acid.

The deodorant active agents may be odor absorbers such as zinc ricinoleates, sodium bicarbonate; metallic or silver or silver-free zeolites, or cyclodextrins and derivatives thereof. They may also be chelating agents such as Dissolvine GL-47-S® from Akzo Nobel, EDTA and DPTA. They may also be a polyol of glycerol or 1,3- propanediol type (for example, Zemea Propanediol sold by Dupont Tate and Lyle BioProducts); or else an enzyme inhibitor such as triethyl citrate; or alum.

The deodorant active agents may also be agents for neutralizing foul smelling volatile compounds, such as sodium bicarbonate, for example sold by Universal Preserv-A-Chem, magnesium carbonate, for example sold by Buschle & Lepper, calcium carbonate, for example sold by Sensient, zinc oxide, for example sold by Kobo, magnesium oxide, for example sold by Dr. Paul Lohmann, calcium oxide or calcium hydroxide; amine derivatives such as tromethamine (for example, TRIS AMINO ULTRA sold by Angus (Dow chemical), triethanolamine, triethylamine and ethanolamine. The amount of the deodorant active agent may range from 1 % to 10%, based on the total weigh of the composition.

ADDITIONAL INGREDIENTS

In addition to the essential components described hereinbefore, the composition of the invention may further comprise any usual cosmetically acceptable ingredient, which may be chosen especially from perfume/fragrance, preserving agents, moisturizers, antioxidants, solvents, actives, vitamins, fillers, polymers, and mixtures thereof.

A person skilled in the art will take care to select the optional additional ingredients and/or the amount thereof such that the advantageous properties of the composition according to the invention are not, or are not substantially, adversely affected by the envisaged addition.

Non-limiting examples of preserving agents which can be used in accordance with the invention include phenoxyethanol and caprylyl glycol. An example of antioxidant is pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate.

Suitable solvents include, but are not limited to alcohols, glycols and polyols such as glycerin, pentylene glycol, butylene glycol, and mixtures thereof.

Non-limiting example of peeling agent is Zinc PCA. In a preferred embodiment, suitable moisturizers of the present invention could be glycerin, hyaluronic acid, glycols like propylene and butylene.

Suitable additional actives include, but are not limited to disodium EDTA, trisodium ethylenediamine disuccinate, triethanolamine, and mixtures thereof.

Non-limiting example of vitamins suitable for the composition of the present invention includes tocopherol.

The additional ingredients may represent from 0.1% to 20%, such as from 0.1% to 15% or such as from 0.1 to 10% by weight, relative to the total weight of the composition of the invention.

By way of non-limiting illustration, the invention will now be described with reference to the following examples.

EXAMPLES

Non-limiting examples of antiperspirant compositions according to the present invention were prepared according to Ex. 1 to 4 below:

EXAMPLE 5 - ANTIPERSPIRANT EFFICACY EVALUATION

The objective of this study was to evaluate/demonstrate the antiperspirant efficacy of the EX. 2 in view of a composition of the state of the art (Ex. 5) at 24 and 48 hours after 4 applications according to FDA protocol.

Twenty female subjects were selected to participate to the present study. During 21 days prior to the application of the investigational product, the subjects only used the standard deodorant delivered by the study staff and no other product on the armpits were used.

After this period, a baseline hot room session (80 minutes, 37.8 ± 1^QC, 30-40% relative humidity) was performed in order to select the subjects who sweat more than 100 milligrams of sweat in each armpit during 20 minutes. After the baseline hot room session, the subjects performed a supervised washing of their armpits with a standard liquid soap and received a controlled application of 0.4g of the product in a randomized way performed by a trained technician. On the two following days (Saturday and Sunday), the subjects were instructed to apply at home the product delivered by the study staff. Then, the subjects returned to the research center for the 2^nd controlled product application performed by a trained technician The amount of product was 0.4g determined by a calibrated pipette.

Hot rooms (80 minutes, 37.8 ± 1^QC, 30-40% relative humidity) were performed again to assess antiperspirant efficacy 24 and 48 hours after the fourth application of the product.

Antiperspirant activity was evaluated by determining shifts in ratios of the sweat output by the treated armpit with the product A to the treated armpit with the product B for each volunteer. Estimates of percent reduction and 95% confidence intervals were calculated. The data was analyzed using the Wilcoxon Signed Rank Test.

The results showed that EX. 2 of the present invention has no statistically significant differences observed 48 hours after 4 applications in view of EX. 5. In other words, EX. 2 presents good antiperspirant performance as EX. 5 of the state of the art.

EXAMPLE 6 - NON-IRRITATIVE CLINICAL TEST

In order to demonstrate the non-irritant effect of the composition of the present invention, a clinical test (Repeated Patch Test with challenge) was performed with Ex. 4.

In this sense, 200 volunteers have used the composition of Ex. 4 during 6 weeks, applying the product 2 to 3 times a day.

As a conclusion, the composition of Ex. 4 presented no irritation nor sensitization to the skin of the volunteers.

Claims

SET OF CLAIMS

1. The antiperspirant composition, comprising:

(a) from 10% to 25% of an antiperspirant active agent, selected from aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrex GLY or aluminum zirconium trichlorohydrate or a mixture thereof;

(b) from 1.5% to 10% of a nonionic surfactant;

(c) from 0.5% to 10% of a thickening agent, selected from steareth- 100/PEG-136/HDI copolymer; and (d) at least 70% of water; wherein the amounts are based on the total weight of the composition.

2. The antiperspirant composition, according to claim 1 , wherein the nonionic surfactant is selected from PPG-26-buteth-26 (and) PEG-40 hydrogenated castor oil.

3. The antiperspirant composition, according to claim 1 , wherein the composition is in the form of a clear gel.

4. The antiperspirant composition, according to claim 1 , wherein the composition may further comprise propylene glycol.

5. The antiperspirant composition, according to claim 4, wherein the amount of propylene glycol is ranging from 1 to 15%, preferably ranging from 5% to

13% and even more preferably ranging from 7% to 10% based on the total weight of the composition.

6. The antiperspirant composition, comprising:

(a) 20% to 25% of an antiperspirant active agent, selected from aluminum zirconium pentachlorohydrate or aluminum zirconium tetrachlorohydrex

GLY or a mixture thereof;

7. A process of manufacturing an antiperspirant composition, comprising: (a) from 10% to 25% of an antiperspirant active agent, selected from aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrex GLY or aluminum zirconium trichlorohydrate or a mixture thereof; (b) from 1.5% to 10% of a nonionic surfactant;

(c) from 0.5% to 10% of a thickening agent, selected from steareth- 100/PEG-136/HDI copolymer; and

(d) at least 70% of water; wherein the amounts are based on the total weight of the composition; in which the process comprises the steps of:

(b) adding to the mixture of step (a), the PPG-26-Buteth-26 (and) PEG-40 Hydrogenated castor oil and the preservative under agitation during 10 min to 15 min; optionally, adding the propylene glycol;

8. Use of the antiperspirant composition, comprising: ((a) from 10% to 25% of an antiperspirant active agent, selected from aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrex GLY or aluminum zirconium trichlorohydrate or a mixture thereof;

(b) from 1.5% to 10% of a nonionic surfactant; (c) from 0.5% to 10% of a thickening agent, selected from steareth-

100/PEG-136/HDI copolymer; and

(d) at least 70% of water; wherein the amounts are based on the total weight of the composition; for the manufacture of a product to be used as an antiperspirant and deodorant daily product.

9. Use, according to claim 7, wherein the antiperspirant daily product is in the form of a clear gel.