WO2021227380A1 - 一种采样拭子用保存管 - Google Patents

一种采样拭子用保存管 Download PDF

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Publication number
WO2021227380A1
WO2021227380A1 PCT/CN2020/124135 CN2020124135W WO2021227380A1 WO 2021227380 A1 WO2021227380 A1 WO 2021227380A1 CN 2020124135 W CN2020124135 W CN 2020124135W WO 2021227380 A1 WO2021227380 A1 WO 2021227380A1
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Prior art keywords
cavity
tube
sampling
swab
preservation
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PCT/CN2020/124135
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English (en)
French (fr)
Inventor
方鹏宇
蒋析文
Original Assignee
广州达安基因股份有限公司
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Priority to EP20855846.0A priority Critical patent/EP3936056A1/en
Priority to US17/273,734 priority patent/US11839877B2/en
Publication of WO2021227380A1 publication Critical patent/WO2021227380A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/022—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle
    • B01L2400/024—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle touch-off at the side wall of the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Definitions

  • the present invention relates to the technical field of sample preservation, and more specifically, to a preservation tube for sampling swabs.
  • sampling swabs for sampling is a simple, painless, and non-invasive DNA specimen collection method. This method is suitable for collecting DNA samples from people of any age.
  • the swab is usually used as a tool for medical examination to collect microorganisms, exfoliated cells or secretions.
  • the sampling swab is stored in a preservation tube for inspection.
  • the current sampling swab preservation tube includes a detachable tube body and a cover body. The sampling swab is sealed and stored in the tube after collecting patient samples, and then sent to the laboratory for nucleic acid extraction and testing.
  • this method currently has many shortcomings:( 1) In the process of nucleic acid extraction in the laboratory, the nucleic acid sample on the swab needs to be shaken and eluted, which is cumbersome and increases the risk of infection caused by the transferred sample; (2) During the detection process, there is no fixed sampling swab in the storage tube. Structure, the swab is easy to tilt in the preservation tube, which affects the detection and sampling operation.
  • the purpose of the present invention is to overcome the deficiencies in the prior art, and provide a preservation tube for sampling swabs, which does not need to be shaken and eluted, and can facilitate subsequent detection and sampling.
  • the technical solution adopted by the present invention is:
  • a preservation tube for sampling swabs which includes a tube body provided with a first cavity for storing a sample release agent and a second cavity for placing the sampling swab, the first cavity and The second cavity is connected and arranged, and the central axis of the second cavity is deviated from the central axis of the tube.
  • the sampling swab is placed in the second cavity, moves up and down in the second cavity and rotates for elution, the nucleic acid samples of the sampling swab are evenly distributed in the sample release agent, and the first cavity is sucked
  • the sample release agent in the body can be used for testing.
  • the present invention omits the process of oscillating elution and extracting nucleic acid samples, and the swab is placed vertically in the second cavity arranged deviating from the center of the tube body, which provides operation space for sampling operation, simplifies the nucleic acid detection operation process, and facilitates the clinical trial operation , To reduce the risk of infection in the detection process.
  • the central axis of the first cavity coincides with the central axis of the tube, and the side of the second cavity is attached to the inner wall of the tube.
  • the first cavity is used to store the sample release agent, and its location is limited to facilitate subsequent automated testing and sampling; the location of the second cavity is defined so that the sampling swab is attached to the inner wall of the tube, so that the sampling swab can stand stably in the second cavity , To prevent the sampling swab from tilting to adversely affect the detection and sampling.
  • the top of the tube body is provided with a first connecting part for connecting the tube cover
  • the bottom of the tube body is provided with a fixing part.
  • the first connecting part is used to connect the tube cover and the tube body to seal the sampling swab and sample release agent in the storage tube
  • the fixed part is used to match the tube body and the fixed table or the fixed instrument, which is beneficial to realize the rotation operation of the tube cover Automation.
  • tops of the first cavity and the second cavity are connected with a second connecting portion, and the second connecting portion surrounds the outer edge of the top of the first cavity and the second cavity and the inner wall of the tube.
  • the inner wall of the second cavity is provided with a plurality of first protrusions.
  • the nucleic acid sample can be better eluted when the sampling swab is moved up and down, rotated and rotated, and on the other hand, it is beneficial for the sampling swab to stand stably in the second cavity and not easy to dump.
  • the first convex portion is a first convex edge
  • the first convex edge is one or a combination of a vertical edge, a horizontal edge, an oblique edge, and a spiral edge.
  • the shape of the first rib is not a limitation of the present invention, and other friction structures that can increase the friction between the sampling swab and the inner wall of the second cavity to improve the elution effect of the sampling swab are applicable to the present invention.
  • the first convex portion is a first convex point.
  • the first bump can be connected to form one or a combination of a vertical edge structure, a horizontal edge structure, an oblique edge structure, and a spiral edge structure. It can also be processed to form an irregular edge structure as needed, not only moving up and down or rotating sampling The swab has a better elution effect, and can save the amount of preparation raw materials.
  • a plurality of second convex portions are evenly distributed on the inner bottom of the second cavity.
  • the first convex part on the side can elute the nucleic acid sample on the side of the sampling swab
  • the second convex part on the bottom can elute the nucleic acid sample on the bottom of the sampling swab, which can improve the up and down movement of the sampling swab.
  • the second convex portion is a second convex rib, one end of the second convex rib is provided at the center of the bottom of the second cavity, and the other end of the second convex rib is connected to the first convex portion.
  • the position and shape setting of the second ribs are preferred for simplifying the mold structure, simplifying the molding process, designing beautifully, and improving the elution effect, and they are not a limitation of the present invention.
  • the second convex portion is a second convex point.
  • the first bumps can be connected to form a radial rib structure distributed radially along the bottom of the second cavity, which not only has a better elution effect when rotating the sampling swab, but also saves the amount of preparation raw materials.
  • first cavity is a tapered hole
  • second cavity is a cylindrical hole
  • depth of the second cavity is greater than the depth of the first cavity.
  • the outer edges of one end of the first cavity and the second cavity are both connected with the second connecting part, and the other end of the second cavity is set lower than the other end of the first cavity to increase the stability of the upright storage of the sampling swab.
  • the first cavity is a tapered hole
  • the second cavity is a cylindrical hole
  • the first cavity and the second cavity are partially overlapped to form a first side edge and a second side edge.
  • the distance between the side edge and the second side edge is not greater than the minimum diameter of the sampling swab, and the sampling swab cannot pass through the gap between the first side edge and the second side edge.
  • the setting of the gap between the first side edge and the second side edge is a preference for obtaining good processing performance and stabilization of the sampling swab, and is not a requirement of the present invention.
  • the preservation tube for sampling swabs of the present invention saves the process of oscillating and eluting nucleic acid samples.
  • the swab is placed vertically in a second cavity set deviated from the center of the tube body, which provides operating space for sampling operations and can simplify nucleic acid
  • the detection operation process facilitates clinical trial operations and reduces the risk of infection during the detection process.
  • Fig. 1 is a perspective view of a preservation tube for sampling swabs in the first embodiment
  • FIG. 2 is a schematic diagram of the structure of the preservation tube for sampling swabs in the first embodiment
  • Figure 3 is a bottom view of the preservation tube for sampling swabs in the first embodiment
  • FIG. 4 is a schematic structural view of the storage tube for sampling swabs with a tube cover installed in the first embodiment
  • Figure 5 is a schematic structural diagram of a storage tube for sampling swabs in the second embodiment
  • Figure 6 is a top view of the storage tube for sampling swabs in the second embodiment
  • Fig. 7 is a perspective view of a preservation tube for sampling swabs in the fourth embodiment
  • FIG. 8 is a schematic diagram of the structure of the preservation tube for sampling swabs in the fourth embodiment
  • Figure 9 is a top view of the storage tube for sampling swabs in the fourth embodiment.
  • FIG. 10 is a top view of the preservation tube for sampling swabs in the seventh embodiment
  • Figures 1 to 4 show the first embodiment of the preservation tube for sampling swabs of the present invention, which includes a tube body 1 in which a first cavity 11 for storing a sample release agent and a The second cavity 12 of the sampling swab, the first cavity 11 and the second cavity 12 are connected and arranged, and the central axis of the second cavity 12 is deviated from the central axis of the tube 1.
  • the elution process of the sampling swab moving up and down and rotating in the second cavity 12 can be made as a mark attached to the outer wall of the tube body 1.
  • the sampling swab is placed in the second cavity 12 after sampling, moves up and down and rotates in the second cavity 12 for elution, the nucleic acid sample of the sampling swab is evenly distributed in the sample release agent, and the first is sucked.
  • the sample release agent in a cavity 11 can be used for detection, so that the process of oscillating elution and extracting nucleic acid samples is omitted.
  • the sampling operation provides operation space, simplifies the nucleic acid detection operation process, facilitates the clinical trial operation, and reduces the risk of infection during the detection process.
  • the size of the second cavity 12 can be set so that the inner wall of the second cavity 12 gently squeezes the sampling swab head.
  • the size of the second cavity 12 is between the maximum diameter of the sampling swab head and the diameter of the sampling swab shaft.
  • the size setting of the second cavity 12 is a preference for better stabilization of the sampling swab, and is not a limitation of the present invention.
  • the communication form between the first cavity 11 and the second cavity 12 can be in multiple communication forms: the first cavity 11 and the second cavity 12 are connected on the side, and when the side is connected, it should be connected to the first cavity.
  • a sufficient amount of sample release agent is added to a cavity 11 and a second cavity 12 so that the liquid level of the sample release agent is higher than the lowest point of communication between the first cavity 11 and the second cavity 12 to ensure that the sample release agent can It flows freely between the first cavity 11 and the second cavity 12; the first cavity 11 communicates with the bottom of the second cavity 12, and when the bottom is connected, the bottom of the first cavity 11 can be set in the second cavity 12 Below the bottom, the sample release agent containing nucleic acid samples can flow smoothly into the first cavity 11 for subsequent testing and sampling.
  • the communication form between the first cavity 11 and the second cavity 12 of the present invention is not limited to the above two forms. Others can ensure the flow of the sample release agent in the first cavity 11 and the second cavity 12 and The connection form in which the sample release agent from which the nucleic acid sample is eluted flows into the first cavity 11 for storage is applicable to the present invention.
  • this embodiment further limits the distribution positions of the first cavity 11 and the second cavity 12 in the tube 1 .
  • the central axis of the first cavity 11 of this embodiment coincides with the central axis of the tube 1, and the side of the second cavity 12 is attached to the inner wall of the tube 1, so that the sampling instrument can be easily extended into the first cavity.
  • the body 11 sucks a sample of the release agent, and the sampling swab is close to the inner wall of the tube body 1 on the inner side of the second cavity 12, so that the sampling swab is stored upright in a relatively stable manner.
  • the top of the tube body 1 is provided with a first connecting portion 13 for connecting the tube cover 2;
  • a fixing part 14 is provided at the bottom of the tube body 1.
  • the structure of the fixing part 14 can be set according to the structure of a fixed instrument or a fixed table.
  • one end of the fixing part 14 is flush with the bottom of the tube body 1, and the fixing part 14 The other end can extend upward to the top edges of the first cavity 11 and the second cavity 12;
  • the connecting portion is an external thread provided on the outer wall of the pipe body 1, and the pipe body 1 and the pipe cover 2 are connected by a screw thread.
  • connection is stable and can be easily automated; as shown in Figure 3, the fixing portion 14 is provided It is a cross structure.
  • the cross structure and the fixed platform are fixed together to prevent the tube body 1 from rotating with the tube cover 2 when the tube cover 2 is rotated.
  • the cross structure is for both better The fixation effect and better processing and forming performance are not made as a limitation of the present invention.
  • the structure of the fixation part 14 in this embodiment can be designed according to a fixation table or a fixation instrument and adapted to it.
  • the second connecting portion 15 is connected to the top of the first cavity 11 and the second cavity 12 in this embodiment.
  • the portion 15 may be circular truncated and surround between the outer edges of the first cavity 11 and the second cavity 12 and the inner wall of the tube 1, as shown in FIG. 2.
  • the second connecting portion 15, the first cavity 11, and the second cavity 12 of this embodiment can be an integrally formed structure, the first cavity 11 and the second cavity 12 partially overlap, and the first cavity 11, the second cavity 12
  • the cross section of the second cavity 12 is a gourd structure.
  • the first cavity 11 and the second cavity 12 are partially overlapped.
  • the spacing can be set according to the molding requirements and the shape and size of the sampling swab.
  • the thickness of the tube body 1, the thickness of the first cavity 11, the thickness of the second cavity 12, the thickness of the fixing part 14, the thickness of the second connecting part 15 of the preservation tube of this embodiment are The dimensions are equal to ensure the cooling effect during the molding process.
  • this is only a preference for obtaining a preservation tube with better performance by using existing production equipment, and is not a limitation of the present invention.
  • Figures 5 to 6 show the second embodiment of the storage tube for sampling swabs of the present invention.
  • This embodiment is the same as the first embodiment. The difference is that this embodiment is provided on the inner wall of the second cavity 12
  • first protrusions 16 on the one hand, the nucleic acid sample can be better eluted when the sampling swab is moved up and down, rotated and rotated, and on the other hand, it is beneficial for the sampling swab to stand stably in the second cavity 12 and not easy to fall.
  • the first convex portion 16 in this embodiment is a first convex edge
  • the first convex edge is one or a combination of a vertical edge, a horizontal edge, an oblique edge, and a spiral edge.
  • the shape of the first ridge listed above is not a limitation of the present invention. Others can increase the friction between the sampling swab and the inner wall of the second cavity 12 to improve the elution effect of the sampling swab. All of the friction structures are applicable to the present invention.
  • the first rib in this embodiment may preferably be a vertical rib, but the first rib is set as a vertical rib for the purpose of facilitating the release of the tube body 1 and is not a limitation of the present invention.
  • the number of the first ribs in this embodiment can be set to 8-12, which evenly surround the inner wall of the second cavity 12.
  • the number of first ribs is not a limitation of the present invention.
  • the number of first ribs can be based on the thickness of the first ribs, the elution effect of the first ribs, The structural parameters of the sampling swab are increased or decreased accordingly.
  • This embodiment is the third embodiment of the storage tube for sampling swabs.
  • This embodiment is the same as the second embodiment. The difference is that this embodiment is provided with a number of first bumps on the inner wall of the second cavity 12, and It is not a continuous structure like the first rib in the embodiment. Compared with the second embodiment, this embodiment can obtain a better elution effect and can save the amount of raw materials used for preparing the tube body 1.
  • the first bumps in this embodiment can be connected to form one or a combination of a vertical rib structure, a horizontal rib structure, an oblique rib structure, and a spiral rib structure, and can also be processed to form an irregular rib structure as required.
  • the shape of the first bump in this embodiment can be set to a hemispherical, rectangular, or other friction structure that can increase the friction between the sampling swab and the second cavity 12 when the sampling swab moves up and down or rotates.
  • the plurality of first convex points of this embodiment may form a vertical rib structure, which evenly surrounds the inner wall of the second cavity 12.
  • Figures 7 to 9 show the fourth embodiment of the storage tube for sampling swabs of the present invention.
  • This embodiment is the same as the second or third embodiment, except that: when the sampling swab is sampled, the nucleic acid The sample is not only adhered to the side of the sampling swab, but also to the bottom of the sampling swab.
  • the inner bottom of the body 12 is provided with a second convex portion 17, so that both the nucleic acid sample at the side of the sampling swab and the nucleic acid sample at the bottom of the sampling swab can be eluted.
  • the second convex portion 17 of this embodiment is a second convex rib, one end of the second convex rib is provided at the center of the bottom of the second cavity 12, and the other end of the second convex rib is connected to the first convex portion 16.
  • the first protrusion 16 is a first rib and a vertical rib
  • the number of the second rib is equal to the number of the first rib
  • the first rib and the second rib can be connected to form an integrated prismatic structure
  • the mold structure design is simple, easy to form, beautiful in design, and has a good elution effect.
  • the structure and number design of the second ribs in this embodiment is an optimization for the aesthetic design and convenient processing, and is not a limitation of the present invention.
  • Other ribs that can achieve the elution effect The structure and the number of ribs are also applicable to the present invention.
  • This embodiment is the same as the second or third embodiment. The difference is that, in addition to the first convex portion 16 surrounding the side wall of the second cavity 12, the second cavity 12 is also located at the inner bottom of the second cavity 12. A second convex portion 17 is provided.
  • the second convex portion 17 of this embodiment is a second convex point, rather than a continuous structure similar to the second convex rib in the fourth embodiment. Compared with the fourth embodiment, this embodiment can obtain better elution. It is effective and can save the amount of raw materials used for preparing the tube body 1.
  • the second bumps in this embodiment can be connected to form a regular arrangement structure, and can also be processed to form an irregular prismatic structure as required.
  • the shape of the second bump in this embodiment can be set to a hemispherical, rectangular, or other friction structure that can increase the friction between the sampling swab and the second cavity 12 when the sampling swab moves up and down or rotates.
  • This embodiment is the same as any one of Embodiments 1 to 5, except that the first cavity 11 in this embodiment is a tapered hole, the second cavity 12 is a cylindrical hole, and the second cavity is The depth of the body 12 is greater than the depth of the first cavity 11, as shown in FIG. 4.
  • Setting the first cavity 11 as a tapered hole facilitates the collection of the sample release agent in the first cavity 11 and increases the liquid surface depth of the sample release agent, which facilitates subsequent detection and sampling;
  • the second cavity 12 is deeper than the first cavity.
  • the depth of the cavity 11 is large, and the bottom of the second cavity 12 is located below the bottom of the first cavity 11.
  • the sampling swab can stand stably in the second cavity 12, preventing the sampling swab from tipping over and affecting the detection and sampling operation. Influence.
  • This embodiment is the same as any one of Embodiments 1 to 5, except that the first cavity 11 in this embodiment is a tapered hole, the second cavity 12 is a cylindrical hole, and the first cavity
  • the diameters of the body 11, the second cavity 12 and the tube body 1 are collinear.
  • the first cavity 11 and the second cavity 12 partially overlap to form a first side edge and a second side edge.
  • the distance between the side edges is not greater than the smallest diameter of the sampling swab, as shown in Figure 10.
  • the communication between the first cavity 11 and the second cavity 12 is not affected, the sample release agent can flow freely between the first cavity 11 and the second cavity 12, and the second cavity can be effectively avoided.
  • the sampling swab in the body 12 is inclined to the side of the first cavity 11.
  • the setting of the gap between the first side edge and the second side edge is an optimization for obtaining good processing performance and stabilization of the sampling swab, and is not a requirement of the present invention.
  • the present invention can also The side plate is connected between the first side edge and the second side edge, and holes or holes are designed on the side plate to realize the connection between the first cavity 11 and the second cavity 12 while preventing the sampling swab from tilting The role of.

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Abstract

一种采样拭子用保存管，包括管体（1），管体（1）内设有用于存储样本释放剂的第一腔体（11）以及用于放置采样拭子的第二腔体（12），第一腔体（11）与第二腔体（12）连通设置，第二腔体（12）的中心轴线偏离于管体（1）的中心轴线。使用时采样拭子放置于第二腔体（12）内，在第二腔体（12）内上下移动及旋转洗脱，采样拭子的核酸样本均匀分布于样本释放剂中，吸取第一腔体（11）内的样本释放剂即可用于检测，省去了振荡洗脱提取核酸样本的过程，拭子竖直放置于偏离于管体（1）中心设置的第二腔体（12）中，为取样操作提供操作空间，简化核酸检测操作过程，方便临床试验操作。

Description

一种采样拭子用保存管 技术领域
本发明涉及样本保存的技术领域，更具体地，涉及一种采样拭子用保存管。
背景技术
在体外诊断领域中，尤其是基因诊断，需要采集人体分离的样品进行检测，采用采样拭子进行采样是简单、无痛、无创的DNA标本采集方法。该方法适用于采集任何年龄段人群的DNA样本。拭子通常作为采集微生物、脱落细胞或分泌物的医学检查的工具，采样拭子保存于保存管内送检。目前的采样拭子保存管包括可拆卸连接的管体和盖体，采样拭子采集患者样品后密封保存在管体内，再送入实验室提取核酸及检测，但目前这种方式存在许多不足：(1)在实验室提取核酸过程中，需振荡洗脱拭子上的核酸样本，操作繁琐，且增加转移样品导致的感染风险；(2)在检测过程中，由于保存管内无固定采样拭子的结构，拭子在保存管内易倾斜，影响检测采样操作。
发明内容
本发明的目的在于克服现有技术中的不足，提供一种采样拭子用保存管，无需振荡洗脱，且可方便后续的检测取样。
为解决上述技术问题，本发明采用的技术方案是：
提供一种采样拭子用保存管，包括管体，所述管体内设有用于存储样本释放剂的第一腔体以及用于放置采样拭子的第二腔体，所述第一腔体与第二腔体连通设置，所述第二腔体的中心轴线偏离于所述管体的中心轴线。
本发明的采样拭子用保存管，采样拭子放置于第二腔体内，在第二腔体内上下移动及旋转洗脱，采样拭子的核酸样本均匀分布于样本释放剂中，吸取第一腔体内的样本释放剂即可用于检测。本发明省去了振荡洗脱提取核酸样本的过程，拭子竖直放置于偏离于管体中心设置的第二腔体中，为取样操作提供操作空间，简化核酸检测操作过程，方便临床试验操作，降低检测过程的感染风险。
进一步地，所述第一腔体的中心轴线与所述管体的中心轴线重合，所述第二腔体侧部贴设于管体内壁。第一腔体用于储存样本释放剂，其位置限定利于后续自动化检测取样；第二腔体的位置限定使得采样拭子贴于管体内壁，使得采样拭子可稳定地立于第二腔体中，防止采样拭子倾斜对检测取样产生不利影响。
进一步地，所述管体顶部设有用于连接管盖的第一连接部，管体底部设有固定部。第一连接部用于管盖与管体连接，将采样拭子及样本释放剂密封保存于保存管内；固定部用于管体与固定台或固定仪器之间的匹配，利于实现管盖旋转操作的自动化。
进一步地，所述第一腔体、第二腔体的顶部连接有第二连接部，所述第二连接部环绕于第一腔体、第二腔体顶部外缘与管体内壁之间。在管体连接上管盖后，在第二连接部、第一腔体、第二腔体、管体及管盖之间形成以密闭空间，拭子及样本释放剂保存在该密闭空间内，可有效保证样品保存的稳定性。
进一步地，所述第二腔体内壁设有若干第一凸部。一方面可在上下移动、旋转及旋转采样拭子时能够较好地洗脱核酸样本，一方面利于采样拭子稳定立于第二腔体内不易倾倒。
进一步地，所述第一凸部为第一凸棱，第一凸棱为竖棱、横棱、斜棱、螺旋棱中的一种或几种的组合。第一凸棱的形状并不作为本发明限制性规定，其他能够增加采样拭子与第二腔体内壁之间摩擦力以改善采样拭子洗脱效果的摩擦结构均可适用于本发明。
进一步地，所述第一凸部为第一凸点。第一凸点可连接形成竖棱结构、横棱结构、斜棱结构、螺旋棱结构中的一种或几种的组合，也可根据需要加工形成不规则棱结构，不仅在上下移动或旋转采样拭子时具有较好的洗脱效果，而且可节省制备原材料用量。
进一步地，所述第二腔体内侧底部均布有若干第二凸部。侧部的第一凸部对采样拭子侧部的核酸样本起到洗脱作用，底部的第二凸部对采样拭子底部的核酸样本起到洗脱作用，可改善采样拭子上下移动及旋转时对采样拭子上样本的洗脱效果。
进一步地，所述第二凸部为第二凸棱，第二凸棱一端设于第二腔体的底部中心，第二凸棱的另一端与第一凸部连接。第二凸棱的位置及形状设置是为了简化模具结构、简化成型工序、设计美观、改善洗脱效果而做出的优选，而并不作为本发明的限制性规定。
进一步地，所述第二凸部为第二凸点。第一凸点可连接形成沿第二腔体底部径向分布的径棱结构，不仅在旋转采样拭子时具有较好的洗脱效果，而且可节省制备原材料用量。
进一步地，所述第一腔体为锥形孔，第二腔体为柱形孔，所述第二腔体的深度大于第一腔体的深度。第一腔体、第二腔体的一端外缘均与第二连接部连接，第二腔体的另一端低于第一腔体的另一端设置，以增加采样拭子竖立保存的稳定性。
进一步地，所述第一腔体为锥形孔，第二腔体为柱形孔，所述第一腔体与第二腔体部分重叠形成有第一侧棱和第二侧棱，第一侧棱、第二侧棱之间距离不大于采样拭子的最小直径，采样拭子无法通过第一侧棱、第二侧棱之间间隙。第一侧棱、第二侧棱之间间隙的设置是为了获得良好的加工性能和采样拭子稳定作用而做出的优选，并不作为本发明的规定。
与现有技术相比，本发明的有益效果是：
本发明的采样拭子用保存管，省去振荡洗脱提取核酸样本的过程，拭子竖直放置于偏离于管体中心设置的第二腔体中，为取样操作提供操作空间，可简化核酸检测操作过程，方便临床试验操作，降低检测过程的感染风险。
附图说明
图1为实施例一中采样拭子用保存管的透视图；
图2为实施例一中采样拭子用保存管的结构示意图；
图3为实施例一中采样拭子用保存管的仰视图；
图4为实施例一中采样拭子用保存管安装有管盖的结构示意图；
图5为实施例二中采样拭子用保存管的结构示意图；
图6为实施例二中采样拭子用保存管的俯视图；
图7为实施例四中采样拭子用保存管的透视图；
图8为实施例四中采样拭子用保存管的结构示意图；
图9为实施例四中采样拭子用保存管的俯视图；
图10为实施例七中采样拭子用保存管的俯视图；
附图中：1-管体；11-第一腔体；12-第二腔体；13-第一连接部；14-固定部；15-第二连接部；16-第一凸部；17-第二凸部；2-管盖。
具体实施方式
下面结合具体实施方式对本发明作进一步的说明。其中，附图仅用于示例性说明，表示的仅是示意图，而非实物图，不能理解为对本专利的限制；为了更好地说明本发明的实施例，附图某些部件会有省略、放大或缩小，并不代表实际产 品的尺寸；对本领域技术人员来说，附图中某些公知结构及其说明可能省略是可以理解的。
本发明实施例的附图中相同或相似的标号对应相同或相似的部件；在本发明的描述中，需要理解的是，若有术语“上”、“下”、“左”、“右”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此附图中描述位置关系的用语仅用于示例性说明，不能理解为对本专利的限制，对于本领域的普通技术人员而言，可以根据具体情况理解上述术语的具体含义。
实施例一
如图1至图4所示为本发明的采样拭子用保存管的第一实施例，包括管体1，管体1内设有用于存储样本释放剂的第一腔体11以及用于放置采样拭子的第二腔体12，第一腔体11与第二腔体12连通设置，第二腔体12的中心轴线偏离于管体1的中心轴线。本实施例采样拭子在第二腔体12内上下移动和旋转的洗脱过程可制作为标识附于管体1外壁。
本实施例实施时，采样拭子采样后放置于第二腔体12内，在第二腔体12内上下移动及旋转洗脱，采样拭子的核酸样本均匀分布于样本释放剂中，吸取第一腔体11内的样本释放剂即可用于检测，如此便省去了振荡洗脱提取核酸样本的过程，拭子竖直放置于偏离于管体1中心设置的第二腔体12中，为取样操作提供操作空间，简化核酸检测操作过程，方便临床试验操作，降低检测过程的感染风险。
为了使得采样拭子稳定的利于第二腔体12中，本实施例可通过设置第二腔体12的尺寸使得第二腔体12内壁轻轻挤压采样拭子头部。具体地，第二腔体12的尺寸介于采样拭子头部最大直径和采样拭子杆部直径之间。但需要说明的是，第二腔体12尺寸设置是为了对采样拭子起到较好的稳定作用而做出的优选，并不作为本发明的限制性规定。
本实施例中，第一腔体11与第二腔体12之间的连通形式可为多种连通形式：第一腔体11与第二腔体12侧部连通，侧部连通时应向第一腔体11和第二腔体12内添加足够量的样本释放剂，使得样本释放剂的液面高于第一腔体11与第二腔体12的最低连通点，以保证样本释放剂可在第一腔体11、第二腔体12之间 自由流动；第一腔体11与第二腔体12底部连通，底部连通时可将第一腔体11的底部设置在第二腔体12底部之下，便于含有核酸样本的样本释放剂可顺利流动至第一腔体11内，备于后续的检测取样。当然，本发明第一腔体11与第二腔体12之间的连通形式并不拘泥于上述两种形式，其他能够保证样本释放剂在第一腔体11和第二腔体12内流动及洗脱有核酸样本的样本释放剂流动至第一腔体11内储存的连通形式均适用于本发明。
为了进一步限制采样拭子在保存管内的保存位置、避免采样拭子位置不当影响检测取样操作，本实施例对第一腔体11、第二腔体12在管体1内的分布位置做进一步限定。具体地，本实施例的第一腔体11的中心轴线与管体1的中心轴线重合，第二腔体12侧部贴设于管体1内壁，如此，可便于取样仪器伸入第一腔体11内吸取样本释放剂，且采样拭子在第二腔体12内一侧紧贴管体1内壁，使得采样拭子较稳定地竖立保存。
在保存管运输转移过程中，应对保存管进行密封处理，故本实施例在管体1顶部设有用于连接管盖2的第一连接部13；为了适用于检测过程的仪器自动化操作，本实施例在管体1底部设置有固定部14，固定部14的结构可根据固定仪器或固定台的结构进行设置，本实施例中固定部14的一端与管体1底部平齐，固定部14的另一端可向上延伸至第一腔体11、第二腔体12的顶部边沿；第二腔体12的一侧部与固定部14相切、另一侧贴设于管体1内壁。本实施例中，连接部为设置管体1外壁的外螺纹，管体1与管盖2之间通过螺纹连接，连接稳定，且可便于实现自动化操作；如图3所示，固定部14设置为十字架结构，在操作管盖2时十字架结构与固定台之间配合固定防止旋转管盖2时管体1跟随管盖2一起转动，但需要说明的是，十字架结构是为了兼具较好的固定效果及较好的加工成型性能而做出的优选，并不作为本发明的局限性规定，本实施例固定部14的结构可根据固定台或固定仪器进行设计并与之适配。
为了在管体1内合理分布第一腔体11、第二腔体12的位置，本实施例在第一腔体11、第二腔体12的顶部连接有第二连接部15，第二连接部15可呈圆台状环绕于第一腔体11、第二腔体12外缘与管体1内壁之间，如图2所示。在管体1连接上管盖2后，在第二连接部15、第一腔体11、第二腔体12、管体1及管盖2之间形成密闭空间，如图4所示，拭子及样本释放剂保存在该密闭空间内，可有效保证样品保存的稳定性。另外，本实施例的第二连接部15、第一腔体11、 第二腔体12可为一体成型结构，第一腔体11与第二腔体12部分重叠，第一腔体11、第二腔体12的截面为葫芦结构，第一腔体11、第二腔体12部分重叠，第一腔体11、第二腔体12连接形成的第一侧棱与第二侧棱之间的间距可根据成型要求及采样拭子的形状尺寸进行设置。
为了赋予保存管产品较好的性能，本实施例保存管的管体1壁厚、第一腔体11壁厚、第二腔体12壁厚、固定部14厚度、第二连接部15厚度等尺寸相等，以保证成型过程中冷却效果。当然，这只是为了利用现有生产设备获得性能较好的保存管而做出的优选，并不作为本发明的限制性规定。
实施例二
如图5至图6所示为本发明的采样拭子用保存管的第二实施例，本实施例与实施例一相同，所不同之处在于，本实施例在第二腔体12内壁设有若干第一凸部16，一方面可在上下移动、旋转及旋转采样拭子时能够较好地洗脱核酸样本，一方面利于采样拭子稳定立于第二腔体12内不易倾倒。
具体地，本实施例中的第一凸部16为第一凸棱，第一凸棱为竖棱、横棱、斜棱、螺旋棱中的一种或几种的组合。当然，需要说明的是，上述列举的第一凸棱的形状并不作为本发明限制性规定，其他能够增加采样拭子与第二腔体12内壁之间摩擦力以改善采样拭子洗脱效果的摩擦结构均可适用于本发明。
本实施例的第一凸棱可优选为竖棱，但第一凸棱设置为竖棱是为了方便管体1脱模而做出的优选，而并不作为本发明的限制性规定。
另外，本实施例的第一凸棱的数目可设置为8-12条，均匀环绕于第二腔体12的内壁。但需要说明的是，第一凸棱的数目并不作为本发明的限制性规定，本实施例中第一凸棱的数量可根据第一凸棱的厚度、第一凸棱的洗脱效果、采样拭子的结构参数做相应增加或减少。
实施例三
本实施例为采样拭子用保存管的第三实施例，本实施例与实施例二相同，所不同之处在于，本实施例在第二腔体12内壁设有若干第一凸点，而不是类似于实施例中第一凸棱这样的连续性结构，相比于实施例二，本实施例可获得更好的洗脱效果且可节省管体1制备原料的用量。
本实施例中的第一凸点可连接形成竖棱结构、横棱结构、斜棱结构、螺旋棱结构中的一种或几种的组合，也可根据需要加工形成不规则棱结构。另外，本实 施例的第一凸点的形状可设置为半球形、方体等可增加采样拭子上下移动或旋转时与第二腔体12之间摩擦力的摩擦结构。
为了便于第一凸部16的加工及第一凸部16的脱模，本实施例的若干第一凸点可形成竖棱结构，均匀环绕于第二腔体12内壁。
实施例四
如图7至图9所示为本发明的采样拭子用保存管的第四实施例，本实施例与实施例二或实施例三相同，所不同之处在于：采样拭子采样时，核酸样本不仅仅粘附在采样拭子的侧部，还粘附在采样拭子的底部，本实施例除在第二腔体12侧壁环绕设有第一凸部16外，还在第二腔体12内侧底部设置有第二凸部17，如此对采样拭子侧部的核酸样本及采样拭子底部的核酸样本均可起到洗脱作用。具体地，本实施例的第二凸部17为第二凸棱，第二凸棱的一端设于第二腔体12的底部中心，第二凸棱的另一端与第一凸部16连接。当第一凸部16为第一凸棱且为竖棱时，第二凸棱的数量与第一凸棱的数量相等，且第一凸棱与第二凸棱可连接形成一体式棱状结构，模具结构设计简单、易于成型、设计美观、且具有较好的洗脱效果。但需要说明的是，本实施例中第二凸棱的结构及数目设计是为了设计美观和加工便捷而做出的优选，并不作为本发明限制性规定，其他能实现洗脱效果的凸棱结构和凸棱数量亦可适用于本发明。
实施例五
本实施例与实施例二或实施例三相同，所不同之处在于，本实施例除在第二腔体12侧壁环绕设有第一凸部16外，还在第二腔体12内侧底部设置有第二凸部17。本实施例的第二凸部17为第二凸点，而不是类似于实施例四中第二凸棱这样的连续性结构，相比于实施例四，本实施例可获得更好的洗脱效果且可节省管体1制备原料的用量。
本实施例中的第二凸点可连接形成规则排布结构，也可根据需要加工形成不规则棱结构。另外，本实施例的第二凸点的形状可设置为半球形、方体等可增加采样拭子上下移动或旋转时与第二腔体12之间摩擦力的摩擦结构。
实施例六
本实施例与实施例一至实施例五中任一实施例相同，所不同之处在于，本实施例的第一腔体11为锥形孔，第二腔体12为柱形孔，第二腔体12的深度大于第一腔体11的深度，如图4所示。将第一腔体11设置为锥形孔，利于样本释放 剂在第一腔体11内汇集及增加样本释放剂的液面深度，利于后续的检测取样；第二腔体12的深度较第一腔体11的深度大，第二腔体12的底部位于第一腔体11的底部之下，采样拭子可稳定地立于第二腔体12内，防止采样拭子倾倒对检测取样操作的影响。
实施例七
本实施例与实施例一至实施例五中任一实施例相同，所不同之处在于，本实施例的第一腔体11为锥形孔，第二腔体12为柱形孔，第一腔体11、第二腔体12及管体1的一直径共线，第一腔体11与第二腔体12部分重叠形成有第一侧棱和第二侧棱，第一侧棱、第二侧棱之间距离不大于采样拭子的最小直径，如图10所示。实施时，既不影响第一腔体11、第二腔体12之间的连通，样本释放剂可在第一腔体11和第二腔体12之间自由流动，又能够有效避免第二腔体12内采样拭子向第一腔体11一侧倾斜。需要说明的是，第一侧棱、第二侧棱之间间隙的设置是为了获得良好的加工性能和采样拭子稳定作用而做出的优选，并不作为本发明的规定，本发明还可通过在第一侧棱、第二侧棱之间连接侧板、在侧板上设计孔隙或孔槽，以实现连通第一腔体11、第二腔体12的同时起到防止采样拭子倾斜的作用。
显然，本发明的上述实施例仅仅是为清楚地说明本发明所作的举例，而并非是对本发明的实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明权利要求的保护范围之内。

Claims (10)

  1. 一种采样拭子用保存管，包括管体(1)，其特征在于，所述管体(1)内设有用于存储样本释放剂的第一腔体(11)以及用于放置采样拭子的第二腔体(12)，所述第一腔体(11)与第二腔体(12)连通设置，所述第二腔体(12)的中心轴线偏离于所述管体(1)的中心轴线。
  2. 根据权利要求1所述的采样拭子用保存管，其特征在于，所述第一腔体(11)的中心轴线与所述管体(1)的中心轴线重合，所述第二腔体(12)侧部贴设于管体(1)内壁。
  3. 根据权利要求1所述的采样拭子用保存管，其特征在于，所述管体(1)顶部设有用于连接管盖(2)的第一连接部(13)，管体(1)底部设有固定部(14)。
  4. 根据权利要求1所述的采样拭子用保存管，其特征在于，所述第一腔体(11)、第二腔体(12)的顶部连接有第二连接部(15)，所述第二连接部(15)环绕于第一腔体(11)、第二腔体(12)顶部外缘与管体(1)内壁之间。
  5. 根据权利要求1所述的采样拭子用保存管，其特征在于，所述第二腔体(12)内壁设有若干第一凸部(16)。
  6. 根据权利要求5所述的采样拭子用保存管，其特征在于，所述第一凸部(16)为第一凸棱或第一凸点，所述第一凸棱为竖棱、横棱、斜棱、螺旋棱中的一种或几种的组合。
  7. 根据权利要求5所述的采样拭子用保存管，其特征在于，所述第二腔体(12)内侧底部均布有若干第二凸部(17)。
  8. 根据权利要求7所述的采样拭子用保存管，其特征在于，所述第二凸部(17)为第二凸棱或第二凸点，所述第二凸棱一端设于第二腔体(12)的底部中心，第二凸棱的另一端与第一凸部(16)连接。
  9. 根据权利要求1至8任一项所述的采样拭子用保存管，其特征在于，所述第一腔体(11)为锥形孔，第二腔体(12)为柱形孔，所述第二腔体(12)的深度大于第一腔体(11)的深度。
  10. 根据权利要求1至8任一项所述的采样拭子用保存管，其特征在于，所述第一腔体(11)为锥形孔，第二腔体(12)为柱形孔，所述第一腔体(11)与第二腔体(12)部分重叠形成有第一侧棱和第二侧棱，第一侧棱、第二侧棱之间距离不大于采样拭子的最小直径。
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113252659B (zh) * 2021-07-06 2021-11-26 广州万孚生物技术股份有限公司 胶体金免疫检测平台和胶体金免疫检测套件
CN115322884B (zh) * 2022-08-11 2023-07-18 上海金域医学检验所有限公司 一种核酸检测装置及其方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040184954A1 (en) * 2003-03-18 2004-09-23 Huiyan Guo Lateral flow immunoassay devices for testing saliva and other liquid samples and methods of use of same
US20040237674A1 (en) * 2003-05-30 2004-12-02 Yuchang Wu Fluid collection and application device and methods of use of same
CN201441389U (zh) * 2009-06-17 2010-04-28 段忠诚 一种液体样本采集装置
CN102854034A (zh) * 2011-06-30 2013-01-02 艾博生物医药(杭州)有限公司 收集流体样本的装置
CN104921760A (zh) * 2015-07-13 2015-09-23 上海慧晨生物医学科技有限公司 收集保存体液的装置及使用方法
CN105748108A (zh) * 2012-10-24 2016-07-13 艾博生物医药(杭州)有限公司 一种装置
CN107036848A (zh) * 2017-04-13 2017-08-11 杭州旭科生物技术有限公司 一种样本收集及检测的装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4184483A (en) * 1973-05-08 1980-01-22 U.S. Medical Research & Development, Inc. Method of and apparatus for collecting cultures
US4813432A (en) * 1987-10-13 1989-03-21 Saint-Amand Manufacturing, Inc. Swab transport system
US20090030342A1 (en) * 2007-07-27 2009-01-29 3M Innovative Properties Company Apparatus and method for releasing a sample of material
US9468423B2 (en) * 2012-01-10 2016-10-18 Becton, Dickinson And Company Safety shield for fluid specimen container
KR101388885B1 (ko) * 2012-06-14 2014-04-23 에스티엑스조선해양 주식회사 곡면 주행용 레일 대차
EP2901129A4 (en) * 2012-09-26 2016-11-02 Ibis Biosciences Inc DUTCH INTERFACE FOR A MICROFLUIDIC DEVICE
MX2016002797A (es) * 2013-09-06 2016-05-26 Theranos Inc Dispositivos, sistemas, metodos y equipos para recibir un hisopo.
KR101591308B1 (ko) * 2013-11-19 2016-02-03 바디텍메드(주) 절취수단을 구비한 시료채취 장치 및 이를 이용한 시료채취 방법
EP3519093B1 (en) * 2016-09-30 2021-03-10 Koninklijke Philips N.V. System for applying a reagent to a sample
CN108636470A (zh) * 2018-02-09 2018-10-12 台州市黄岩方野科技发展有限公司 一种宫颈癌诊断用样本管

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040184954A1 (en) * 2003-03-18 2004-09-23 Huiyan Guo Lateral flow immunoassay devices for testing saliva and other liquid samples and methods of use of same
US20040237674A1 (en) * 2003-05-30 2004-12-02 Yuchang Wu Fluid collection and application device and methods of use of same
CN201441389U (zh) * 2009-06-17 2010-04-28 段忠诚 一种液体样本采集装置
CN102854034A (zh) * 2011-06-30 2013-01-02 艾博生物医药(杭州)有限公司 收集流体样本的装置
CN105748108A (zh) * 2012-10-24 2016-07-13 艾博生物医药(杭州)有限公司 一种装置
CN104921760A (zh) * 2015-07-13 2015-09-23 上海慧晨生物医学科技有限公司 收集保存体液的装置及使用方法
CN107036848A (zh) * 2017-04-13 2017-08-11 杭州旭科生物技术有限公司 一种样本收集及检测的装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3936056A4 *

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