WO2021227110A1

WO2021227110A1 - Cooperative microwave and radio-frequency rotary irradiation full-field thermotherapy instrument for tumor

Info

Publication number: WO2021227110A1
Application number: PCT/CN2020/091337
Authority: WO
Inventors: 尚圣杰; 尚诚德; 尚志英
Original assignee: 尚圣杰
Priority date: 2020-05-13
Filing date: 2020-05-20
Publication date: 2021-11-18
Also published as: CN111840807A

Abstract

Disclosed is a cooperative microwave and radio-frequency rotary irradiation full-field thermotherapy instrument for a tumor, the instrument comprising a temperature measurement unit (2), a full-field irradiation unit (3), a therapeutic thermal insulation compartment (1), and a control unit (4), wherein the full-field irradiation unit (3) comprises a microwave irradiation mechanism, a capacitive radio-frequency irradiation mechanism and a rotation mechanism, and the microwave irradiation mechanism and the capacitive radio-frequency irradiation mechanism are arranged on one or two full-field irradiation rings (33). The control unit (4) cooperatively uses the advantages of rotary irradiation of the two heating modes, i.e. microwave heating and capacitive radio-frequency heating, so as to carry out depth-layered complementary diathermy on a human body, and achieves full-field precise high-fever heating for the radical treatment of a tumor by means of a precise temperature measurement and control technique. The thermotherapy instrument is a pure physical precise temperature-control thermotherapy device which is safe, convenient and efficient, can be used for the radical treatment of various solid tumors while keeping normal tissues and organs intact, has advantages for tumor treatment, such as having a short time, causing a small amount of pain and having a low cost, and has a wide range of indications.

Description

Microwave radio frequency synergistic rotation irradiation tumor whole-area hyperthermia instrument

Technical field

The invention relates to the technical field of tumor hyperthermia, in particular to a microwave radio frequency coordinated rotation irradiation tumor whole-area hyperthermia instrument.

Background technique

Hyperthermia is derived from the case study of tumor disappearance after high fever, and an innovative technology to treat tumors by heating. It is recognized by the industry as the fifth largest tumor treatment method after surgery, radiotherapy, chemotherapy, and biological therapy, and pointed out Hyperthermia is a green therapy.

In this regard, many countries have actively carried out research and adopted various heating methods to verify the theory of hyperthermia. Successive results have proved the effectiveness of hyperthermia for the treatment of cancer, and the development of hyperthermia equipment has a good prospect.

The inventor of the present inventors comprehensively believes that to achieve radical cure of tumors, clarify the mechanism of hyperthermia treatment, seek global hyperthermia technology, optimize the best temperature range for high fever and blanching, and ensure accurate temperature control have become four major technical problems. .

The inventors have also conducted in-depth research on cancer cells and found that due to the rapid differentiation, uncontrolled growth, and infinite proliferation of gene mutations in cancer cells, they need to absorb a large amount of nutrients from the outside under normal circumstances and input excessive oxygen. At this time, the stress response is that respiration will rapidly intensify. Due to the mutation defects such as tissue vascular disorder and obstruction due to cancer cell gene mutations, it is difficult to adapt to the excessive demand for oxygen by cancer cells under high fever. As a result, it will cause anaerobic respiratory stress and anorexia. The accumulation of a large amount of lactic acid produced by oxygen does not have time to efflux, leading to the acidification of cancer cell tissues. These acidifying substances cause fatal harm to cancer cell tissues:

The acidic environment will inhibit the replication of cancer cell proteins and chromosomes, leading to failure of proliferation. Although cancer cells can continue to survive without being scalded to death, they will no longer differentiate and proliferate, which is equivalent to losing their replication function and falling into an apoptotic state. This inactive cancer cell is then eliminated in two ways: one is that it will continue to die one by one with the metabolism, and the other is that its acidic characteristics are more easily recognized and eliminated by immune cells such as lymph. Therefore, the blow of high fever and blanching to cancer cells is an irreversible killing. One or more hyperthermia can achieve a radical cure.

In the human body tolerable temperature range (within 47℃), the higher the temperature, the stronger the anaerobic respiratory stress of cancer cells, and the more thorough the apoptosis caused by the acidification of cancer cell tissues. The high fever over 42℃ lasts for more than 30 minutes. The apoptotic rate exceeds 90%, but the temperature exceeds 43℃, and the high fever will be more and more harmful to the normal cells of the human body. Therefore, the best temperature range for high-temperature blanching should be 42℃-43℃, and the highest limit should not exceed 43℃. 43°C is the temperature difference that cancer cells and normal human cells can tolerate. It can inactivate cancer cells and cause less damage to normal cells. This makes it possible for hyperthermia to cure tumors.

Through research, it is found that although various current tumor hyperthermia methods are feasible, they also have some problems/deficiencies, which affect the final curative effect to varying degrees, making it difficult to cure tumors with existing hyperthermia technologies.

In order to facilitate the improvement of the process and the development of more scientific and reasonable hyperthermia technology, we have carried out a systematic analysis and research on various existing hyperthermia methods, found out the crux of the problem, and proposed improvement ideas.

At present, hyperthermia is divided into two categories: one is non-equipment hyperthermia. Most of them are based on the most primitive cases of measles or malaria infection with high fever to treat cancer, and inject “toxin” into cancer patients to induce infection and fever, so as to burn the cancer cells. These methods have definite results, but the risks are difficult to control and cannot be promoted.

The other is equipment-type hyperthermia, which uses equipment to heat to kill cancer cells. According to different heating methods, the equipment-type hyperthermia methods are divided into the following types:

One is the space capsule tumor hyperthermia system, which allows patients to be placed in the space capsule to perform hyperthermia with infrared rays or high-temperature steam. Although this is a global heating idea, because the human body has the function of self-defense, it resists the outside through sweating High temperature guarantees a constant temperature inside the human body, so infrared rays or high-temperature steam have a poor effect on the human body, and it is difficult for the deep part of the human body to reach high temperatures. This equipment is only effective for shallow tumors that have not metastasized and spread.

The second is a tumor microwave hyperthermia device. Theoretically, the following four characteristics of microwave are very suitable for making a tumor hyperthermia instrument: ①The heating penetration is good: the inside and outside of the medium can be heated uniformly at the same time; ②Select heating: only for The water-containing tissue generates heat, but almost penetrates through the tissues with low water content such as fat and protein without generating heat; ③The thermal inertia is small, and it stops when you stop, which is conducive to precise temperature control; ④Non-ionizing: the effect of microwave on the human body Only physical heating effect, no chemical hazard.

However, from the reported practical application of various microwave hyperthermia instruments, the effect of tumor treatment is not ideal. In-depth research has found that the root cause is: firstly, the depth of microwave penetration is not enough, usually no more than 6cm (including fat thickness), and the directional heating coverage area is very large. Small, limited to the treatment of superficial tumors that have not metastasized.

The third is the tumor radiofrequency hyperthermia device. This is a new type of electromagnetic hyperthermia device developed based on the research on the defects of microwave hyperthermia technology. Although it has broken through the limitation of the depth of diathermy, the application effect is still not optimistic, and it is difficult to cure the spread and metastasis. Tumor.

Through in-depth research on various radio frequency hyperthermia devices, it is found that these radio frequency hyperthermia devices have two common problems: first, radio frequency heating can easily lead to overheating of the superficial fat layer, which must be laminated with a water bag for cooling treatment, and secondly, the current The radio frequency hyperthermia device adopts multiple groups of capacitive radio frequency heating mechanisms to directional cross radiation to strengthen the heating and scald the found tumor lesions, and lacks global hyperthermia thinking and radical cure concepts.

Compared with other hyperthermia methods, microwave and radio frequency hyperthermia are regarded as the most promising methods for the treatment of tumors. However, the curative effect of current microwave hyperthermia and radio frequency hyperthermia is mediocre. I have found the root cause through in-depth research and innovatively proposed Based on a new idea, the following analyzes and introduces the idea and principle of the present invention based on the comparison of the heating effects of microwave and capacitive radio frequency static irradiation and rotary irradiation.

As shown in Figure 2, when the microwave magnetron is irradiated at rest and not rotating, the range of the heating area facing the irradiation is not large, and the temperature rise from the outside to the inside is as follows: the fat layer is about 2 cm difficult to heat, and when it is next to the muscles under the fat layer When the layer temperature rises to 42°C, the fat can only heat up to 37.3°C, which decreases with the increase in depth. The muscle layer with a depth of 2-6cm drops from 42°C to 41.5°C, and the temperature in the area deeper than 6 cm drops to 39°C. Below, but still significantly higher than 37°C, this is related to the inward heat conduction in the adjacent high-temperature zone. The microwave magnetron static radiation heating area is small and shallow, which only has a therapeutic effect on superficial non-metastatic tumors, but is not effective for superficial metastatic or deep tumors.

As shown in Figure 4, when irradiated statically, the capacitive radio frequency plate penetrates deeply, and can penetrate 26cm of the human body to form a band-shaped heating area. Since there are fewer blood vessels in the fat and slow heat dissipation, and more blood vessels in the muscles, the heat dissipation is faster. Therefore, the two outer fat areas of the band-shaped heating zone heat up quickly, and the fat heats up slowly to other tissues. The temperature decreases with the increase in depth. The central position has the lowest temperature. . Therefore, when a set of capacitive radio frequency plates are used for static radiation heating, when the deep tissue reaches a treatment temperature of 42°C, the temperature of the fat area at both ends will far exceed the tolerable limit temperature, and it must be pasted on the skin next to the fat. Comes with a cold water bag for cooling to prevent fat from overheating and hardening.

As shown in Figure 5, in order to solve the problem of overheating and hardening of the fat layers at both ends and insufficient deep heating temperature when a single capacitive radio frequency mechanism is irradiated, it is proposed to allow two or more sets of capacitive radio frequency mechanisms to cross-irradiate under static conditions. The heat in the intersection area is focused to form a high temperature zone that is higher than the temperature of the fat layer. Before the fat layer is overheated and hardened, the high temperature zone is allowed to fall on the tumor focus, which has a good scalding effect on the deep tumor.

From the above analysis, it can be seen that whether it is microwave heating or radio frequency heating, under static conditions, only non-metastatic solid tumors with a clear target can be effectively treated with thermotherapy, and the effects of non-solid tumors and metastatic spread cannot be taken into account. Hyperthermia for solid tumors ultimately cannot avoid recurrence, and it is difficult to achieve a radical cure.

There are many types of tumors, and the current methods of hyperthermia have not achieved good results. This fully reflects the complexity and difficulty of classification treatment. We believe that to use hyperthermia to cure tumors, it is necessary to break through the inertial thinking of only hyperthermia for tumor lesions.

Hyperthermia originally originated from the human body with high fever and accidentally cured cancer tumors. Therefore, the ideal state of hyperthermia is to return to the mechanism of high fever treatment. High fever treatment reflects the global warming thinking. Whether hyperthermia can cure tumors, we think Three keys must be grasped:

The first is whether it can fully imitate the mechanism of achieving high fever and embody the concept of global killing; the second is whether the critical temperature can be found accurately, and the most recognized critical temperature should be 42-43 based on the current research results. In the ℃ range, lower than this critical temperature will greatly reduce the therapeutic effect, and higher than this critical temperature will cause serious harm to the patient's body. The third is whether the hyperthermia can be accurately controlled to reach this critical temperature.

In order to reflect the global concept of high-firing cancer, the heating method makes full use of the respective advantages of microwave and radio frequency radiation heating, breaking through the traditional static radiation thinking constraints, and innovatively adopts the combination of microwave rotary irradiation and radio frequency rotary radiography, through complementary advantages , Fully heating the patient's treatment area, through artificial precision high fever, to achieve a radical treatment effect.

The effect of microwave rotation heating is shown in Figure 3. When the magnetron rotates and irradiates the human body, the surface layer of about 2 cm thick fat tissue is not easy to heat. In the low temperature zone, the fat layer will form inward within the depth of 2-6 cm of the human body. An annular high temperature ring, the temperature of the high temperature ring gradually decreases from the outside to the inside, and there is no temperature rise in the inner tissue after the depth exceeds 6 cm.

The effect of capacitive radio frequency rotation heating is shown in Figure 6. When one or more pairs of capacitive radio frequency plates rotate and irradiate the human body, the heat accumulated in the fat in the small peripheral area under static condition is dispersed as the plates rotate. In the peripheral fat circle, the high-temperature area of fat becomes the low-temperature area. On the contrary, as the plate rotates, the deep tissues within the fat layer get heat focus, forming a high-temperature round cake, and the temperature gradually rises from the outside to the inside.

Synergistic use of microwave and capacitive radio frequency heating mechanism for superimposition of rotating radiation, that is, the heating effect after superimposing the rotating radiation of Figure 3 and Figure 6 is shown in Figure 8. The fat layer becomes a low temperature area and is protected, avoiding overheating and hardening, and microwave inward The high temperature ring formed by the rotating irradiation range and the round cake-shaped high temperature zone formed by the capacitive radio frequency rotating irradiation can complement each other. The unbalanced small temperature difference between the tissues can be achieved through heat The heat transfer between the adjustment and the tissues will eventually reach a temperature balance between the inside and outside until the predetermined temperature rises.

Finally, the optical fiber temperature measurement data is used as the reference frame to realize the non-invasive and accurate temperature measurement in the body at all times with the help of nuclear magnetic thermal imaging technology. The temperature measurement data is transmitted to the intelligent control unit to accurately control the temperature of the patient's treatment area not to exceed the tolerance limit of 42-43 ℃ in real time, and It can maintain the treatment time, realize the full-area heating that mimics the high fever, and achieve the purpose and effect of radical treatment.

Summary of the invention

The purpose of the present invention is to provide a microwave radio frequency synergistic rotation irradiation tumor global hyperthermia instrument, so as to realize the hyperthermia effect of simulating a high fever of the human body with uniform heat throughout the body.

The purpose of the present invention is also to provide a full-area hyperthermia instrument to achieve uniform body heat and simulate high fever in the human body.

To this end, one aspect of the present invention provides a microwave radio frequency coordinated rotation irradiation tumor global hyperthermia instrument, including a temperature measurement unit, a global irradiation unit, a treatment insulation chamber, and a control unit, wherein the global irradiation unit includes A microwave irradiation mechanism, a capacitive radio frequency irradiation mechanism and a rotating mechanism, the microwave heating mechanism and the capacitive radio frequency heating mechanism are arranged on one or two global irradiation rings, and the control unit is used for coordinating the microwave and the capacitive radio frequency The heating method of rotating radiation method performs depth-layered complementary diathermy on the human body, and uses the temperature measuring unit to accurately measure the temperature in real time for precise temperature control, to achieve precise high fever and blanching throughout the area, which is used for radical treatment of tumors.

The thermotherapy instrument can detect the temperature of any place in the human body treatment area by using a temperature measurement unit, and includes an optical fiber temperature measurement device and a nuclear magnetic thermal imaging device. The temperature measurement unit uses the temperature data obtained by the optical fiber temperature measurement device as the reference frame and uses the nuclear magnetic thermal imaging technology to calculate and process the accurate temperature data of each point in the treatment area, so as to achieve non-invasive and accurate temperature measurement in the body.

The rotating mechanism of the hyperthermia instrument is used to drive the global irradiation ring to rotate or brake according to the control program.

This hyperthermia instrument is a purely physical and precise temperature-controlled hyperthermia device, which is safe, convenient and efficient. It can not only cure various solid tumors but also keep normal tissues and organs intact. It has the characteristics of short time, less pain and low cost for tumor treatment. , A wide range of indications.

According to another aspect of the present invention, there is provided a global hyperthermia apparatus, including a global irradiation unit, the global irradiation unit including a microwave irradiation mechanism, a capacitive radio frequency irradiation mechanism, and a rotating mechanism, the microwave heating mechanism, The capacitive radio frequency heating mechanism is jointly arranged on one irradiation ring or on two irradiation rings respectively, and the rotating mechanism is used to drive the irradiation ring to rotate, wherein the microwave and capacitive radio frequency two kinds of rotary irradiation The heating method is matched to realize the complementary heat penetration of the heating object in depth and layer, so as to achieve high fever and blanching in the whole area.

This hyperthermia instrument uses the advantages of deep radio frequency heating to uniformly heat all points in the treatment area, and the radio frequency heating is rotary heating to avoid the overheating of the surface fat layer caused by radio frequency radiation, and it can focus the deep layer to high temperature, and use microwave selection The characteristic of sexual heating is to avoid the superficial fat layer through rotating radiation, and to compensate the defect of insufficient heat of the inner and middle layer of fat due to radio frequency rotating radiation, so as to achieve overall uniform heating.

On the basis of realizing the full-area radiation mode of uniformly hot all over the body, this hyperthermia instrument also takes into account the respective advantages of the existing microwave radiation mode and radio frequency radiation mode, giving physicians more and more flexible options for hyperthermia.

As a realization method of global high fever blanching, the hyperthermia instrument can be applied in occasions where global high fever blanching is required, including but not limited to tumor hyperthermia, and the application objects include but not limited to the human body.

In addition to the objectives, features, and advantages described above, the present invention has other objectives, features, and advantages. Hereinafter, the present invention will be described in further detail with reference to the drawings.

Description of the drawings

The drawings of the specification constituting a part of the application are used to provide a further understanding of the present invention, and the exemplary embodiments and descriptions of the present invention are used to explain the present invention, and do not constitute an improper limitation of the present invention. In the attached picture:

Fig. 1 is a schematic diagram of the structure of a thermotherapy apparatus according to the present invention;

2 is a schematic diagram of the structure of the radio frequency microwave superimposed radiation ring of the thermotherapy apparatus according to the present invention;

Fig. 3 is a heating effect diagram of microwave static heating in the thermotherapy apparatus according to the present invention;

Fig. 4 is a heating effect diagram of microwave rotary heating in the thermotherapy apparatus according to the present invention;

Fig. 5 is a heating effect diagram of radio frequency static heating in the thermotherapy apparatus according to the present invention;

Fig. 6 is a heating effect diagram of radio frequency bidirectional static heating in the thermotherapy apparatus according to the present invention;

Fig. 7 is a heating effect diagram of radio frequency rotary heating in the thermotherapy apparatus according to the present invention;

Figure 8 is a heating effect diagram of the radio frequency microwave rotation superimposed in the thermotherapy apparatus according to the present invention;

Fig. 9 is a schematic diagram of setting two global irradiation rings in the thermotherapy apparatus according to the present invention;

Fig. 10 is a schematic diagram of the temperature measurement unit and the global irradiation unit in the thermotherapy apparatus according to the present invention are arranged on the guide rail.

Detailed ways

It should be noted that the embodiments in the application and the features in the embodiments can be combined with each other if there is no conflict. Hereinafter, the present invention will be described in detail with reference to the drawings and in conjunction with the embodiments.

Figures 1 to 10 show some embodiments according to the present invention.

As shown in FIG. 1, the microwave radio frequency global irradiation thermotherapy apparatus includes a thermal insulation chamber 1, a temperature measurement unit 2, a global irradiation unit 3, and a control unit 4.

The thermal treatment warehouse 1 includes a warehouse body 11, a warehouse seat 12 and a head seat 13. The bin body 11 includes a head protection bin 111 and a trunk support bin 112.

The bin body 11 is horizontally slidably supported on the bin base 12 and is driven by the drive mechanism provided in the bin base 12. After the bin body 11 passes through the temperature measuring unit 2 and the global irradiation ring 3 in turn, its head protection bin 112 Supported on the head base 13.

The temperature measurement unit 2 is used for real-time measurement of the temperature of any part of the human body section, and includes a nuclear magnetic thermal imaging device for collecting the temperature field distribution map of the human body section and an optical fiber temperature measurement device for temperature measurement at a temperature calibration point.

The temperature measurement method of the temperature field distribution map is as follows: First, the sensor fiber of the fiber optic temperature measuring device is introduced into the human esophagus, stomach or intestine through the mouth, nose or anus in a non-invasive manner. The sensor fiber can accurately measure the path Point temperature value, take these points on the sensing fiber as temperature calibration points, and then scan the cross-section of the human body by the nuclear magnetic thermal imaging device to obtain the temperature field distribution map. Since the temperature calibration points are also in the thermal imaging scanning range, these calibration points are accurate The temperature value is a reference, and the temperature value of each point in the thermal imaging range can be obtained in real time by comparing the temperature difference according to the temperature field distribution map.

As shown in Figure 2, the global irradiation unit 3 includes a global irradiation ring 33, a microwave irradiation mechanism, a capacitive radio frequency irradiation mechanism, and a rotating mechanism. The rotating mechanism includes a base 31, a rotating drum 32, a driving roller 34, and a number of supports.滚35。 Roll 35. Among them, the rotating drum 32 is placed on the base 31 and supported by a number of supporting rollers 34, driven to rotate by the driving roller 33, and drives the global irradiation ring 33 to rotate.

The global irradiation ring 33 is provided with one or more microwave magnetrons 37 of the microwave irradiation mechanism and one or more pairs of capacitive plates 36 of the capacitive radio frequency irradiation mechanism. Among them, the capacitive plate 36 and the microwave magnetic The control tubes 37 are arranged at intervals in the circumferential direction of the torus.

The microwave magnetron 37 is used for microwave heating, and its frequency can be selected in the range of 300MHz-3000MHz. The other microwave magnetron 37' has the same frequency range and can choose microwave devices with different powers. The capacitor plate 36 is used for radio frequency diathermy, and its frequency can be selected in the range of 1MHz-300MHz, and the high frequency band realizes non-contact heating of the skin. The other capacitor plate 36' can be eccentrically arranged to solve the problem of weak heat accumulation in the middle layer.

The rotating mechanism is used to drive the global irradiation ring to rotate or brake according to the control program.

The control unit 4 is used to control the rotation speed of the global radiation ring 33, the radio frequency and power of the capacitor plate 36 (36'), the microwave frequency and power of the microwave magnetron 37 (37'), and the feeding position of the bin body 12 .

In the thermal insulation chamber of the thermotherapy instrument, the base drives the chamber body to feed, and the feeding position is controllable. The nuclear magnetic thermal imaging device can collect the temperature field distribution diagram of the human body section containing the optical fiber temperature probe, and use the optical fiber temperature probe The real-time measured temperature is used to display the temperature of any part of the cross section of the human body after temperature calibration of the temperature field distribution map. The global irradiation unit has five modes: microwave stationary mode, microwave rotating mode, radio frequency stationary mode, radio frequency rotating mode, and microwave radio frequency combined mode for physicians to choose from.

This hyperthermia instrument uses the advantages of deep radio frequency heating to uniformly heat all points in the treatment area, and the radio frequency heating is rotary heating to avoid the overheating of the surface fat layer caused by radio frequency radiation, and it can focus the deep layer to high temperature, and use microwave selection The characteristic of sexual heating avoids the shallow fat layer to ensure that the fat will not overheat. The middle layer high temperature ring is formed by rotating radiation, and the middle layer inside the fat is heated by insufficient heat due to the radio frequency rotation radiation to achieve overall uniformity. heating. The frequency of radio frequency should be 1-300MHz, and the frequency of microwave should be 300MHz-3000MHz.

In one embodiment, on the global irradiation ring 33, one or more pairs of capacitor plates 36 and a number of microwave magnetrons 37 are arranged in different planes, that is, the ring surface where one or more pairs of capacitor plates 36 are located and The torus where the several microwave magnetrons 37 are located are staggered or completely staggered on the central axis of the global irradiation ring 33 to avoid being coplanar.

The following describes the global heating mechanism of the global radiation ring 33 of the present invention with a set of heating effect diagrams.

The microwave magnetron 2 uses 900MHz700W, and a pair of capacitor plates 1 uses 40MHz1000W. The circular section of the carcass membrane with a radius of 13 cm simulates the cross section of the human body. The outermost layer is the 2 cm thick carcass as the fat layer. Take the lining as the muscle layer, place it in an environment of 37.3℃, and arrange optical fiber sensors to measure temperature from the center to the edge with different depths.

As shown in Figure 3, the irradiated area directly opposite the magnetron is the local hyperthermia area. The temperature of the epidermis outside the fat layer is used as the temperature measurement base point. When the muscle layer in the fat layer is heated to 43°C, the temperature rises The rule is as follows: the skin temperature is 37.5℃, the fat layer is about 2 cm thick, it is not easy to heat, the temperature is about 38℃, the temperature of the muscle layer in the fat layer decreases with the increase of depth, from 43℃ to 41.5℃, when the heating depth reaches Above 4 cm, the temperature drops sharply to below 38.5°C, and this part of the temperature rise is related to heat conduction.

As shown in Figure 4, the irradiated area facing the magnetron rotating irradiation is a ring-shaped area, that is, a ring-shaped section around the outer circumference of the body. The skin temperature outside the fat layer is used as the temperature measurement base point. When the layer is heated to 43°C, the fat layer is about 2 cm, which is still difficult to heat. The temperature is 37.9°C. The temperature of the muscle layer in the fat layer decreases with the increase in depth, from 43°C to 41°C. When the heating depth reaches 4 cm or more At that time, the temperature was 39°C.

As shown in Figure 5, the radius of the heating circle section is 13 cm. The belt-shaped area where a pair of capacitor plates face each other is the effective heating area. The fat layer dissipates slowly. The outer skin temperature of the fat layer is used as the temperature measurement base point. , When the temperature of the fat layer is heated to 42°C, the temperature of the muscle layer under the fat layer decreases to the center of the section as the depth increases, from 42°C to 41°C.

As shown in Figure 6, the cross-belt-shaped area where the two pairs of capacitor plates face each other is the effective heating area, and the fat layer heats slowly. Taking the outer skin temperature of the fat layer as the temperature measurement base point, the temperature of the fat layer is heated to 42 At ℃, the temperature of the muscle layer under the fat layer decreases with the increase in depth, from 42°C to 41.5°C, but the temperature in the central overlapping area of the cross-shaped zone increases to 43°C.

As shown in Figure 7, the irradiated area facing a pair of capacitor plates 36 when they are individually rotated and heated is the entire heating circle section with a radius of 13 cm. With the central temperature as the base point of temperature measurement, when the central area is heated to 43°C , The temperature of the heating circle section increases with the increase in depth, from 43°C to 38°C from the central area to the fat layer.

FIG. 8 shows the heating effect diagram of the global radiation ring 33. As shown in Figure 8, the irradiated area facing the pair of capacitor plates 36 and the microwave magnetron 37 during synchronous rotation and heating is the entire heating circle section with a radius of 13 cm. The temperature of the central area and the outer skin temperature of the fat layer are measured as At the base temperature, when the central area is heated and stabilized to 42.7°C by radio frequency rotary diathermy, the top muscle under the fat layer is then stabilized to 42.8°C by microwave heating. After a period of slow heating, the entire heating circle section is finally uniform through heat conduction. The state reaches 43°C, realizing full-area heating except for the outer fat layer.

The present invention also provides a global heating method. First, a pair of capacitor plates are heated with a larger first set power, such as 1000W, and a microwave magnetron is heated with a second set power, such as 700W, based on the temperature and fat of the center area. The lower muscle layer is the limit temperature measurement point, which makes the two parts of the human body quickly heat up to 40-41℃, and then a pair of capacitor plates and microwave magnetrons are slowly supplemented with the third set power and the fourth set power, such as 100W. Heat, heat conduction through adjacent tissues is gradually uniform and accurate to 43°C.

In the above global heating method, the heating parameters are only exemplary, and are specifically set by the physician.

Fig. 9 is a schematic diagram of two global irradiation rings set up in the accurate high fever global scalding cancer killing device in the body. As shown in FIG. 9, unlike the microwave irradiation mechanism and the capacitive radio frequency irradiation mechanism in the embodiment shown in FIG. The capacitive radio frequency irradiation mechanism is arranged on the irradiating ring 33a and the second irradiating ring 33b, and the two rotate independently of each other.

Figure 10 is a modified structure of the accurate high fever global scalding cancer killing device in the body. As shown in FIG. 10, unlike the fixed layout of the temperature measurement unit and the global irradiation unit in the embodiment shown in FIG. Reciprocating sliding movement is convenient for mobile temperature measurement.

The above are only preferred embodiments of the present invention and are not used to limit the present invention. For those skilled in the art, the present invention can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

A microwave radio frequency coordinated rotation irradiation tumor global hyperthermia instrument, which is characterized by comprising a temperature measuring unit, a global irradiation unit, and a control unit, wherein the global irradiation unit includes a microwave irradiation mechanism and a capacitive radio frequency irradiation The microwave heating mechanism and the capacitive radio frequency heating mechanism are arranged on one or two global irradiation rings. The control unit is used to coordinate the rotary irradiation of the two heating methods of microwave and capacitive radio frequency, which is effective for the human body. Carry out depth and shallow layered complementary diathermy, and use the temperature measuring unit to accurately measure the temperature in real time for precise temperature control, to achieve precise high fever and blanching in the whole area, which is used for radical treatment of tumors.
The microwave radio frequency coordinated rotation irradiation tumor global hyperthermia device according to claim 1, wherein the temperature measurement unit is used to detect the temperature of any place in the human body treatment area, and includes an optical fiber temperature measurement device and a nuclear magnetic thermal imaging device. Device, the temperature measurement unit uses the temperature data obtained by the optical fiber temperature measurement device as the reference frame and uses the nuclear magnetic thermal imaging technology to calculate and process the accurate temperature data of each point in the treatment area, so as to realize real-time non-invasive accurate temperature measurement in the body.
The microwave radio frequency coordinated rotation irradiation tumor global hyperthermia device according to claim 1, characterized in that it further comprises a thermal insulation chamber for treatment, and the thermal insulation chamber for treatment includes a chamber base, a chamber body that is slidable on the chamber base, and The head base, wherein the cartridge body is supported on the head base after passing through the nuclear magnetic thermal imaging device and the global irradiation unit in sequence.
The microwave radio frequency synergistic rotation irradiation tumor global hyperthermia device according to claim 1, wherein the microwave heating is selected from microwave devices with a frequency of 300 MHz to 3000 MHz.
The microwave radio frequency coordinated rotation irradiation tumor global hyperthermia device according to claim 1, wherein the radio frequency heating is selected from radio frequency devices with a frequency of 1 MHz to 300 MHz.
The microwave radio frequency coordinated rotation irradiation tumor global hyperthermia device according to claim 1, wherein the rotating mechanism is used to drive the global irradiation ring to rotate or brake according to a control program.
A global hyperthermia apparatus, comprising a global irradiation unit, characterized in that the global irradiation unit includes a microwave irradiation mechanism, a capacitive radio frequency irradiation mechanism and a rotating mechanism, and the microwave heating mechanism and the capacitive radio frequency heating mechanism They are jointly arranged on one irradiation ring or on two irradiation rings respectively, and the rotating mechanism is used to drive the irradiation ring to rotate, wherein the two rotating irradiation heating methods of microwave and capacitive radio frequency are matched, Realize the layered complementary heat penetration of the heating object to achieve high fever and blanching in the whole area.
The global hyperthermia apparatus according to claim 7, further comprising a temperature measurement unit for real-time non-invasive temperature measurement of the heated object, and the temperature measurement unit includes an optical fiber temperature measurement device and a nuclear magnetic thermal imaging device.
The global hyperthermia device according to claims 7 and 8, characterized in that it further comprises a thermal insulation chamber for treatment, and the thermal insulation chamber for treatment includes a chamber base, a chamber body slidable on the chamber base, and a head base, wherein: The bin body is supported on the head base after passing through the nuclear magnetic thermal imaging device and the global irradiation unit in sequence.
The global hyperthermia apparatus according to claim 7, wherein the nuclear magnetic thermal imaging device and the global irradiation unit are jointly arranged on a guide rail and can slide back and forth along the guide rail.