WO2021215149A1 - Dispositif cosmétique - Google Patents

Dispositif cosmétique Download PDF

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Publication number
WO2021215149A1
WO2021215149A1 PCT/JP2021/010821 JP2021010821W WO2021215149A1 WO 2021215149 A1 WO2021215149 A1 WO 2021215149A1 JP 2021010821 W JP2021010821 W JP 2021010821W WO 2021215149 A1 WO2021215149 A1 WO 2021215149A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrode
pulse train
alternating current
application
voltage
Prior art date
Application number
PCT/JP2021/010821
Other languages
English (en)
Japanese (ja)
Inventor
山▲崎▼　岩男
Original Assignee
ヤーマン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2020076278A external-priority patent/JP7572159B2/ja
Application filed by ヤーマン株式会社 filed Critical ヤーマン株式会社
Publication of WO2021215149A1 publication Critical patent/WO2021215149A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Definitions

  • the present invention relates to a cosmetological device that applies a voltage to the skin.
  • a method in which a drug, cosmetics, or other substance is non-invasively permeated from the surface of the skin to the inside by applying a voltage to the skin. For example, by applying a pulse voltage, the structure of cells is changed, and in particular, electroporation (electroporation method) that makes it easier to take in macromolecules, and by passing a weak electric current, active ingredients contained in beauty essence, etc. are released. Those that are ionized and then permeated (generally called "iontophoresis”) are known.
  • Patent Document 1 describes applying a single pulse and a pulse group in order to efficiently deliver the active ingredient to the dermis layer.
  • An object of the present invention is to improve the penetrating power of a drug or the like into the skin.
  • the present invention comprises a first electrode and a second electrode arranged on the same surface, a third electrode not on the same surface, and a first generation means for generating an AC pulse train.
  • a beauty device having a control means for alternately repeating the application of the alternating current using the second electrode and the application of the alternating current at a predetermined cycle.
  • the penetration of the drug or the like into the skin is promoted.
  • External view (back side) of the beauty device 10. Schematic diagram of the contact portion.
  • the functional block diagram of the beauty device 10. The figure which shows the waveform example of the applied voltage.
  • FIG. 1 is an external view (front side) of the beauty device 10
  • FIG. 2 is an external view (back side).
  • the beauty device 10 is a device that at least exerts an action of permeating a substance such as a drug or a lotion from the surface of the user's skin (skin) to the inside by applying a voltage to the user's skin.
  • a stimulating action or a thermal action on muscles may be exerted.
  • the user holds the housing 190 by hand, and the head portion provided with the first electrode 111 and the second electrode 112 is previously coated with a substance to be permeated (for example, a face, but a foot, etc.). It can be used by pressing it against any part of the user's body as long as it is a part other than the gripping hand.
  • the beauty device 10 has a substantially round bar-shaped housing 190, and on the surface of the housing 190, the first electrode 111, the second electrode 112, the switches 121 and 122 are on the front side, and the third electrode 113 is on the back side. And has a power supply terminal 130.
  • the switches 121 and 122 are operated by the user to input commands such as power ON / OFF and setting, execution, and interruption of various operations.
  • the housing 190 includes a portion that can be gripped by the user (so-called handle portion).
  • the first electrode 111 and the second electrode 112 are portions that come into contact with a portion to which a voltage is to be applied (in other words, a portion to which a substance is desired to permeate).
  • the first electrode 111 and the second electrode 112 are arranged on substantially the same surface (in other words, so that the heights (thicknesses) from the respective housings 190 are substantially equal). As a result, when the head portion is naturally pressed against the target portion, the first electrode 111 and the second electrode 112 both form a contact portion that comes into contact with the portion.
  • the third electrode 113 on the back side of the housing 190 comes into contact with the user's hand in the used state.
  • the third electrode 113 does not necessarily have to be on the back side, and may be provided at a position where it comes into contact with the user's hand.
  • the third electrode 113 is preferably located at a position away from the first electrode 111 and the second electrode 112 (that is, the target portion), and may not be at least on the same surface as the first electrode 111 and the second electrode 112. Further, in FIG. 2, the third electrode 113 is substantially square, but its shape, size, position, and thickness are arbitrary. In short, the third electrode 113 may function as one of the electrodes for applying a voltage to the skin of the user.
  • the first electrode 111 and the second electrode 112 are annular (substantially annular in this example), respectively, and are arranged concentrically so that the second electrode 112 is on the outside.
  • FIG. 3 is an enlarged schematic view of a portion that comes into contact with the skin.
  • the widths of the first electrode 111 and the second electrode 112 are w1 and w2, respectively.
  • the first electrode 111 and the second electrode 112 are arranged on concentric circles separated by a distance d1 in the radial direction.
  • d1 is 1 mm (millimeter) to 3 mm
  • the voltage application mechanism described in the functional block diagram described later is built in the housing 190.
  • FIG. 4 is a functional block diagram of the beauty device 10. Elements that are not directly related to the present invention have been discarded.
  • the beauty device 10 includes a power supply 160, a first power supply circuit 161, a second power supply circuit 162, a third power supply circuit 163, a DC pulse train generator 152, an AC generator 153, a first electrode 111, a second electrode 112, and a third electrode. It has 113, a first switching unit 171, a second switching unit 172, a third switching unit 173, and a fourth switching unit 174.
  • the power supply 160 is a battery that stores electric power supplied via the power supply terminal 130.
  • the electric power supplied from the power supply 160 is distributed to the first power supply circuit 161 and the second power supply circuit 162 and the third power supply circuit 163.
  • the first power supply circuit 161 and the second power supply circuit 162 and the third power supply circuit 163 include a rectifying circuit, a circuit for modulating amplitude, frequency, phase, etc., and input electric signals to a control unit 151 and a DC pulse train generator, respectively. 152, Converted to an electric signal suitable for operating the AC generator 153 and output.
  • the direct current pulse train generation unit 152 generates a direct current (unipolar) pulse train according to S1 supplied from the control unit 151, and supplies the direct current (unipolar) pulse train to the third electrode 113 and the first switching units 171 and 172.
  • the AC generation unit 153 generates an AC voltage according to S2 supplied from the control unit 151, and supplies the AC voltage to the third switching unit 173 and the fourth switching unit 174.
  • the first switching unit 171 to the fourth switching unit 174 select the DC pulse train and the alternating current to the first electrode 111, the second electrode 112, and the third electrode 113 according to the control signal supplied from the control unit 151, respectively. Apply as a target. Specifically, the first switching unit 171 applies the voltage supplied from the DC pulse train generation unit 152 to the first electrode 111 according to S3 supplied from the control unit 151. The second switching unit 172 applies the voltage supplied from the DC pulse train generation unit 152 to the second electrode 112 according to S4 supplied from the control unit 151. The third switching unit 173 applies the voltage supplied from the AC generating unit 153 to the first electrode 111 according to S5 supplied from the control unit 151. The fourth switching unit 174 applies the voltage supplied from the AC generating unit 153 to the second electrode 112 according to S6 supplied from the control unit 151.
  • the DC pulse train generated by the DC pulse train generation unit 152 is applied with the first electrode 111 and the second electrode 112 as one common (equal potential) electrode and the third electrode 113 as the other electrode. ..
  • the AC voltage generated by the AC generating unit 153 is applied with the first electrode 111 as the positive electrode (or the negative electrode) and the second electrode 112 as the negative electrode (or the positive electrode).
  • the term "DC pulse train” as used herein means not only a waveform having a sharp peak but also a waveform in which an arbitrary unipolar waveform (for example, a square wave or a triangular wave) is regularly repeated. Further, the “alternating current” in the present specification is not limited to a sine wave, but may be another waveform as long as it is bipolar.
  • the control unit 151 generates control signals S1 to S6 so that the above-mentioned application of the DC pulse train and the application of the AC are alternately repeated at a predetermined cycle, and the DC pulse train generation unit 152, the AC generation unit 153, and the first Output to 1 switching unit 171 to 4th switching unit 174. Specifically, the control unit 151 sets the control signals S1, S3, and S4 as ON signals, while the control signals S2, S5, and S6 are set as OFF signals, so that the first state in which the DC pulse train is applied is set only for the first period.
  • the control signals S1, S3, and S4 are set to OFF signals, while the second state of applying AC by supplying ON signals to S2, S5, and S6 is maintained for the second period, and this is repeated thereafter. ..
  • one of the first electrode 111 and the second electrode 112 may function as a positive electrode or a negative electrode, and the other may be insulated.
  • control unit 151, the DC pulse train generation unit 152, and the AC generation unit 153 are implemented as a signal processing processor or module having a function of generating an arbitrary waveform.
  • the functions of the control unit 151, the DC pulse train generation unit 152, the AC generation unit 153, the first switching unit 171, the second switching unit 172, the third switching unit 173, and the fourth switching unit 174 are independent DC pulse trains. It may be realized by a relay or a switch element for switching between a circuit for applying and a circuit for applying AC times.
  • a non-contact relay using a semiconductor such as MOS EFT is used.
  • FIG. 5 is a schematic diagram of a waveform example of the applied voltage.
  • the horizontal axis shows time and the vertical axis shows voltage (amplitude).
  • the scale in the vertical and horizontal directions is different from the actual value for convenience of explanation.
  • a voltage V1 and a rectangular DC pulse train are continuously applied at a repetition frequency F1 over an application period T1, and immediately thereafter, an alternating current of a sinusoidal waveform having an amplitude V2 and a frequency F2 is continuously applied over the application period T2. Then, immediately after that, the voltage V1 and the rectangular DC pulse train are continuously applied at the repetition frequency F1 over the application period T1, and so on.
  • the application of alternating current in the waveform profile is repeated.
  • the application periods T1 and T2 are, for example, 0.1 seconds to 10 seconds, preferably 3 seconds to 6 seconds, respectively.
  • the above-mentioned values of applied voltage (amplitude), application period, and frequency (repetition frequency) are examples, and are examples of the molecular weight and other properties of the drug to be permeated, the resistance value of the user's skin, and the experience given to the user ( It can be set in consideration of other purposes (including discomfort) and other purposes (purpose of obtaining a thermal effect, purpose of giving muscle vibration), and the like.
  • the inventor of the present application regularly repeats the application of voltages having two different waveforms, that is, a DC pulse train and an alternating current, thereby causing an electroporation effect caused by the application of the DC pulse train and the application of alternating current. It was found that the so-called iontophoresis effect can coexist.
  • a pulse train instead of a single pulse for a predetermined period, the hole is maintained in an open state without closing immediately, and by applying an AC voltage during this period, the substance moves efficiently. it seems to do.
  • the DC pulse train is applied over a period of about several seconds, a relatively low voltage is sufficient to obtain an electroporation effect rather than a short pulse. This reduces the burden on the user (discomfort, etc.).
  • the electrode to be used is switched in conjunction with the switching of the applied voltage among the three electrodes. That is, while the first electrode 111 and the second electrode 112, which are relatively close to each other and are suitable in consideration of the discomfort given to the user when applying alternating current, are used as the electrode pairs, when the DC pulse train is applied, A relatively distant first electrode 111 (and second electrode 112) and a third electrode 113, which are at a distance suitable for applying direct current, are used as an electrode pair. At this time, by making the first electrode 111 and the second electrode 112 function as one electrode, the effective area of the electrodes is increased, and as a result, the permeation effect of the drug is increased.
  • a non-contact relay such as a semiconductor element
  • quick switching is realized compared to the case of using hardware.
  • switching is performed at intervals of several seconds.
  • a switching element it is expected that a load will be applied to the element, but when a non-contact relay is used, the switching is performed. There is no such risk, and the durability and reliability of the device are improved.
  • the first electrode 111 and the second electrode 112 do not have to be a perfect circle, but may have an elliptical shape, a teardrop shape (raindrop shape), a polygonal shape, a rectangular shape, or any other annular shape.
  • protrusions may be formed on the outer peripheral surface or the inner peripheral surface of the annulus.
  • the annular means any figure having a hollow portion.
  • it is preferable that the distance between the electrodes is as constant as possible.
  • another annular electrode may be provided inside the first electrode 111 or outside the second electrode 112.
  • the first electrode 111 may have a non-hollow shape such as a disk.
  • the first electrode 111 and the second electrode 112 are not one ring each, but are arranged, for example, by combining two semi-circular rings and arranging them apart from each other, or by combining four quarter-arc rings and arranging them apart from each other. Therefore, the configuration may be such that it can be regarded as one annular shape as a whole.
  • the first electrode and the second electrode arranged on the same plane, the third electrode not on the same plane, and the voltage of the first waveform (for example, a DC pulse train)
  • a second generating means for generating a voltage of a second waveform for example, an AC voltage
  • the third electrode for example, an AC voltage
  • a control means that alternately repeats the application of the voltage of the first waveform using at least one of the above and the application of the AC voltage using the first electrode and the second electrode at a predetermined cycle. It suffices to have.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Dans le but d'améliorer la capacité de pénétration de la peau d'un agent cutané tel qu'un médicament, le dispositif cosmétique (10) selon la présente invention est constitué de manière à comprendre : une première électrode (111) et une deuxième électrode (112) disposées sur le même plan ; une troisième électrode (113) non disposée sur le même plan ; un premier moyen de génération (152) pour générer un train d'impulsions de courant continu ; un deuxième moyen de génération (153) pour générer un courant alternatif ; et un moyen de commande (151) pour répéter alternativement dans un cycle prédéterminé l'application du train d'impulsions à courant continu au moyen de la troisième électrode et la première électrode et/ou la deuxième électrode, et l'application du courant alternatif au moyen de la première électrode et la deuxième électrode.
PCT/JP2021/010821 2020-04-22 2021-03-17 Dispositif cosmétique WO2021215149A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020076278A JP7572159B2 (ja) 2020-04-22 美容器
JP2020-076278 2020-04-22

Publications (1)

Publication Number Publication Date
WO2021215149A1 true WO2021215149A1 (fr) 2021-10-28

Family

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Application Number Title Priority Date Filing Date
PCT/JP2021/010821 WO2021215149A1 (fr) 2020-04-22 2021-03-17 Dispositif cosmétique

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JP (1) JP2023115168A (fr)
CN (1) CN113521522B (fr)
WO (1) WO2021215149A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0473059A (ja) * 1990-07-13 1992-03-09 Ya Man Ltd 美容装置
JP2004129866A (ja) * 2002-10-10 2004-04-30 Ya Man Ltd 電子トリートメント装置
WO2004047915A1 (fr) * 2002-11-27 2004-06-10 Ya-Man Ltd. Dispositif de traitement electronique
JP2005125075A (ja) * 2003-07-18 2005-05-19 Ya Man Ltd 美肌装置
JP2007029518A (ja) * 2005-07-28 2007-02-08 Chiken Kk トリートメント装置
JP2019055052A (ja) * 2017-09-21 2019-04-11 ヤーマン株式会社 美容処理装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7113821B1 (en) * 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
CN100453132C (zh) * 2005-03-30 2009-01-21 上海塔瑞莎健康科技有限公司 促进透明质酸经皮吸收的创伤溃疡治疗仪
JP2007195607A (ja) * 2006-01-24 2007-08-09 Transcutaneous Technologies Inc 薬物投与方法および薬物投与装置
JP2009011589A (ja) * 2007-07-05 2009-01-22 Atomu Giken:Kk イオン性薬物導入装置
JP5963412B2 (ja) * 2011-09-14 2016-08-03 日立マクセル株式会社 美容装置
JP2013099478A (ja) * 2011-11-09 2013-05-23 Shiseido Co Ltd 美容機器、美容方法、情報処理装置、及び情報処理プログラム
JP6131009B2 (ja) * 2012-08-10 2017-05-17 株式会社 Ｍｔｇ 美容器具
JP6282049B2 (ja) * 2012-08-10 2018-02-21 株式会社 Ｍｔｇ 美容器具
JPWO2016068199A1 (ja) * 2014-10-31 2017-08-10 株式会社 Ｍｔｇ 美容器具
JP2016202660A (ja) * 2015-04-24 2016-12-08 株式会社レイア 美顔器及び美顔システム
JP6643700B2 (ja) * 2015-10-15 2020-02-12 株式会社アイリカ イオン導入美容器
CN108853720A (zh) * 2018-05-16 2018-11-23 邱骅轩 一种用于美容领域的自适应透皮离子电渗法导入系统

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0473059A (ja) * 1990-07-13 1992-03-09 Ya Man Ltd 美容装置
JP2004129866A (ja) * 2002-10-10 2004-04-30 Ya Man Ltd 電子トリートメント装置
WO2004047915A1 (fr) * 2002-11-27 2004-06-10 Ya-Man Ltd. Dispositif de traitement electronique
JP2005125075A (ja) * 2003-07-18 2005-05-19 Ya Man Ltd 美肌装置
JP2007029518A (ja) * 2005-07-28 2007-02-08 Chiken Kk トリートメント装置
JP2019055052A (ja) * 2017-09-21 2019-04-11 ヤーマン株式会社 美容処理装置

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CN113521522A (zh) 2021-10-22
CN113521522B (zh) 2024-01-12
JP2021171236A (ja) 2021-11-01
JP2023115168A (ja) 2023-08-18

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