WO2021210490A1

WO2021210490A1 - Adhesive sheet for skin

Info

Publication number: WO2021210490A1
Application number: PCT/JP2021/014918
Authority: WO
Inventors: 英淑権; 田中　弘; 文男神山
Original assignee: コスメディ製薬株式会社
Priority date: 2020-04-13
Filing date: 2021-04-08
Publication date: 2021-10-21
Also published as: KR20230002372A; JP2021167293A; CN115397401A

Abstract

Provided is an adhesive sheet for skin, which has a satisfactory adhesion force, and in which a drug can be stably dissolved or uniformly dispersed, and which is produced using an acrylic copolymer having excellent solubility in a hydrophilic medium.　The adhesive sheet for skin includes an adhesive layer comprising an acrylic resin having "hardness" of 2.0 or less and/or having "an IR intensity ratio" of 2.0 or more. The "hardness" refers to a value (unit: N) of a compressive stress at a depth of compression of 0.1 to 0.2 mm in a (compressive stress)-to-(depth of compression) curve, in which the (compressive stress)-to-(depth of compression) curve is produced by producing a sheet having a thickness of 3 mm from an acrylic resin and then compressing a stainless cylinder having a diameter of 1.5 mm from the upper surface of the sheet at a compression rate of 0.5 mm/min using a compact tabletop tester "EZ Test EZSX" (Shimadzu Corporation).

Description

Adhesive sheet for skin

The present invention relates to an adhesive sheet for skin.

Conventionally, as an external preparation or a cosmetic, a patch for skin application such as a poultice, a cooling sheet, a tape, etc., in which a hydrophilic external adhesive composition for skin having adhesiveness on a support is spread, has been developed. Such a preparation is required to be in close contact with the skin for a predetermined time without peeling, and it is also important to stably disperse or dissolve the drug in the pressure-sensitive adhesive layer.

As conventional patches, many patches using a hydrophilic pressure-sensitive adhesive composition use sodium polyacrylate as a pressure-sensitive adhesive, and are composed mainly of aluminum salts of aliphatic carboxylic acids such as polyacrylic acid. Ship drug containing a polymer gel in its composition (Patent Document 1) A transdermal absorbable preparation consisting of polyacrylic acid having a 10% aqueous solution viscosity of 100 to 1000 cps, a water-soluble polymer, polyhydric alcohol, and water (Patent Document 2). ), N-vinylacetamide / sodium acrylate copolymer, water-soluble aluminum salt, water-containing gel patch consisting of water (Patent Document 3), poultice to which polybutene and gelatin are added (Patent Document 4), and the like are known. There is. However, the conventional hydrophilic pressure-sensitive adhesive composition and the hydrophilic patch have problems such as insufficient adhesive strength and difficulty in practical use.

Japanese Unexamined Patent Publication No. 60-226808 Japanese Unexamined Patent Publication No. 6-135828 Japanese Unexamined Patent Publication No. 9-143060 Japanese Unexamined Patent Publication No. 9-208462

An object of the present invention is to improve the solubility of the above-mentioned acrylic copolymer in a hydrophilic medium and the adhesive strength to the skin. That is, it is an object of the present invention to provide an adhesive sheet for skin using an acrylic copolymer which has sufficient adhesive strength, can stably dissolve or uniformly disperse a drug, and has excellent solubility in a hydrophilic medium. ..

As a result of diligent research to solve the above-mentioned problems, the present inventors have made alkyl acrylate copolymer ammonium, alkyl acrylate / vinyl acetate copolymer, and styrene / alkyl acrylate copolymer ammonium as typical examples. We have found that by using an adhesive, an adhesive sheet for skin having excellent adhesive strength to the skin and a good feeling of use and capable of stably dissolving or uniformly dispersing the drug can be obtained, and the present invention has been completed. I arrived.
The present invention is as shown below.
[1] An adhesive sheet for skin containing an adhesive layer containing an acrylic resin having a "hardness" of 2.0 or less and / or an "IR strength ratio" of 2.0 or more.
[2] The adhesive sheet according to [1], wherein the acrylic resin has a "hardness" of 2.0 or less and an "IR strength ratio" of 2.0 or more.
[3] In [1] or [2], the acrylic resin is at least one selected from the group consisting of alkyl acrylate copolymer ammonium, alkyl acrylate / vinyl acetate copolymer and styrene / alkyl acrylate copolymer ammonium. The described adhesive sheet.
[4] The pressure-sensitive adhesive sheet according to any one of [1] to [3], wherein the pressure-sensitive adhesive layer further contains a surfactant.
[5] The pressure-sensitive adhesive sheet according to [4], wherein the surfactant is a surfactant having an HLB value of 3.5 or more and 12 or less.
[6] The pressure-sensitive adhesive sheet according to [4] or [5], wherein the content of the surfactant is 1% by mass or more and 20% by mass or less.
[7] The pressure-sensitive adhesive sheet according to any one of [1] to [6], wherein the pressure-sensitive adhesive layer further contains a polyhydric alcohol.
[8] The pressure-sensitive adhesive sheet according to any one of [1] to [7], wherein the pressure-sensitive adhesive layer further contains valuable skin resources.
[9] A support made of the adhesive sheet according to any one of [1] to [8] and an acrylic resin having a "hardness" of 5.0 or more and an "IR strength ratio" of less than 2.0. A laminated adhesive sheet for skin that is made by laminating a body sheet.

The adhesive sheet for skin of the present invention has strong adhesive strength and is excellent in stable solubility or uniform dispersibility of drugs and the like.

Adhesive / Adhesive Layer As the adhesive layer in the present invention, an adhesive sheet prepared by using a commercially available adhesive can be used. Rubber-based adhesives are not preferable because they have low water vapor permeability and tend to accumulate sweat and cause skin irritation in summer. Silicone adhesives generally have low adhesiveness and may cause inconvenience in use. An acrylic pressure-sensitive adhesive is preferable in consideration of adhesion to the skin and adhesion to the support film.

Specifically, it is a copolymer of an acrylic acid alkyl ester and a copolymer of acrylic acid, acrylamide, vinyl acetate, etc. mainly containing an acrylic acid alkyl ester. Plasticizers such as glycerin, isopropyl myristate or isopropyl palmitate may be added to these adhesives to improve skin adhesion. The thickness of the adhesive layer is exemplified by 10 μm to 800 μm. In particular, in the case of application to the skin, 50 μm to 500 μm is preferable, and 100 μm to 300 μm is more desirable in order to improve the usability. When it is 100 μm or less, a good feel is obtained in terms of usability, but since it is thin, usability may deteriorate.
Further, these pressure-sensitive adhesives may be used by using one kind of pressure-sensitive adhesive as a sheet, but may also be used by laminating the pressure-sensitive adhesive on several layers.

Many adhesive acrylic ester resins are commercially available, and their mechanical properties have been measured in order to select resins having physical properties that can be used as adhesives. A sheet with a thickness of 3 mm was prepared from several types of acrylic resin, and a stainless steel cylinder with a diameter of 1.5 mm was compressed from above using a small tabletop tester EZ Test EZSX (manufactured by Shimadzu Corporation) (compression speed: 0.5 mm). / min). The value of the compressive stress (N: unit) at a compressive depth of 0.1 to 0.2 mm at which a stable compressive stress is obtained on the obtained compressive stress to compressive depth curve is defined as "hardness" in the present invention. ..
"Hardness" means that a sheet with a thickness of 3 mm is prepared from acrylic resin, and a stainless steel cylinder with a diameter of 1.5 mm is compressed from the top surface of the sheet using a small tabletop tester EZ Test EZSX (manufactured by Shimadzu Corporation). The value (unit: N) of the compressive stress at a compressive depth of 0.1 to 0.2 mm in the obtained compressive stress to compressive depth curve after compression at 5 mm / min.

The infrared absorption spectrum of the acrylic resin was further measured to determine whether it could be used as an adhesive or as a support film. In the infrared absorption spectrum of the acrylic resin, the ratio of the absorption intensity of the absorption intensity and 1230 cm ^-1 vicinity peak of 2900 cm ^-1 vicinity peak (Int1230cm ^{^-1} / Int2900cm ^-1), hereinafter referred to as "IR intensity ratio". Incidentally, 1230 cm ^-1 is derived from C-O-C bending vibration in an acrylic ester, 2900 cm ^-1 is derived from C-H, the _{C-H 2} stretching vibration.

As a result of evaluating the hardness of many of the tested resins, their adhesiveness, and the mechanical strength, the acrylic resin having a hardness of 4.0 or less, preferably 3.0 or less, more preferably 2.0 or less is the acrylic in the present invention. It turned out to be suitable as an adhesive.
As a result of evaluating the IR strength ratio of many of the tested resins and their adhesiveness, it was found that an acrylic resin having an IR strength ratio of 2.0 or more is preferable as the acrylic pressure-sensitive adhesive in the present invention.

A measurement example is described below.
Vinizol 1087FT (Acrylate Cosme Ammonium, manufactured by Daido Kasei Kogyo Co., Ltd., (Hardness: 0.2) (IR intensity ratio: 2.9)), Iodosol GH800 F (Aluminum alkyl acrylate copolymer, Axonobel Co., Ltd.) (Hardness: 0.8) (IR strength ratio: 3.3)), MASCOS (registered trademark) 10 adhesive (acrylic ester, manufactured by Cosmed Pharmaceutical Co., Ltd., (hardness: 0.4) (IR strength) Ratio: 2.24)), etc. can be suitably used as an adhesive.

Iodosol GH41F (Styrene / Alkyl Acrylate Copolymer Ammonium, AkzoNobel Co., Ltd. (Hardness: 8.2), (IR Strength Ratio: 1.1)) can be used for hard supports, but for adhesive applications. Is unsuitable.

Support As the film used for the support, a film made of a synthetic polymer is preferable, and it is necessary that the film has excellent adhesiveness to an acrylic pressure-sensitive adhesive, can maintain strength, and can be easily formed into a thin film. Conventionally used polyolefins, PET (polyethylene terephthalate), polyvinyl alcohol, polyurethane, etc. can also be used, but in the present invention, the affinity with the acrylic pressure-sensitive adhesive is good, and therefore the adhesiveness is excellent and hard. Acrylic resins can be preferably used.
As the support, a support sheet made of an acrylic resin having a "hardness" of 5.0 or more can be preferably used, the "hardness" is 5.0 or more, and the "IR strength ratio" is 2. A support sheet made of an acrylic resin of less than 0 can be more preferably used.

Skin valuables In addition to the above support and adhesive layer, the adhesive layer may contain skin valuables in the present invention. The skin valuables are not particularly limited as long as they are valuables absorbed through the skin. For example, pigmentation inhibitor, moisturizer, metabolism activator, antioxidant, active oxygen scavenger / radical scavenger, fat metabolism promoter, anti-inflammatory agent, blood flow promoter, testosterone 5α reductase activity inhibitor, hair Examples include a papillary activator, a hair growth promoter, and the like.

Anti-pigmentation agent An anti-pigmentation agent can be added to the present invention. Specific examples of the pigmentation inhibitor include p-aminobenzoic acid derivative, sartylic acid derivative, benzenesulfonamide derivative, imidazole derivative, naphthalene derivative, hydroxyanthranic acid or a salt thereof, and their derivatives, anthranic acid derivative, coumarin derivative, and allantin. Derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof, tocopherols or salts thereof and derivatives thereof, and the like can be mentioned.

Moisturizer A moisturizer can be added to the present invention. Specific examples of moisturizers include quince seeds, agar or derivatives thereof, casein, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, pyrarose, 1,3-butylene glycol, glycerin, propylene glycol, etc. Polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and sorbitol, 1,2-propanediol, 1,3- Propylene glycol, polypropylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, erythritol , Pentaerythritol, dipentaerythritol, xylitol, martitol, inositol, pantenol, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylation Chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethyl cellulose, methyl cellulose , Carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropylmethyl cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, polyacrylic acid salt, carboxyvinyl polymer, dermatan sulfate, Water-soluble polymers such as keratane sulfate, pyrrolidone carboxylic acid or a salt thereof, polyglutamic acid or a salt thereof, pyrrolidone carboxylic acid contained in a natural moisturizing factor, urea, urocanic acid, betaine, sodium lactate, aspartic acid, glutamate, isoleucine. , Histidine, phenylalanine, threonine, serine, valine, proline, glycine, alanine, lysine, arginine, ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6II, ceramides such as ceramide 9. ..

Metabolite activator A metabolism activator can be added to the present invention. Specific examples of the metabolic activator include vitamin A group: retinol or a salt thereof and a derivative thereof, retinal or a salt thereof and a derivative thereof, dehydroretinal or a salt thereof and a derivative thereof, retinoic acid or a salt thereof and a derivative thereof. , Carotene or its salts and their derivatives, lycopene or its salts and their derivatives,
B vitamins: thiamine or salts thereof and derivatives thereof, riboflavin or salts thereof and derivatives thereof, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, cyanocobalamine or salts thereof and derivatives thereof, folic acid Or salts thereof and derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof, choline or salts thereof and derivatives thereof, inositol or salts thereof. And their derivatives,
Vitamin C group: ascorbic acid or salts thereof and their derivatives,
Vitamin D group: ergocalciferol or its salt and its derivatives, choleciferol and its salts and their derivatives,
Vitamin E group, etc .: tocopherols or salts thereof and derivatives thereof, tocotrienols or salts thereof and derivatives thereof, ubiquinone or salts thereof and derivatives thereof, linolenic acid or salts thereof and derivatives thereof, linolenic acid or salts thereof and their salts. Derivatives,
Amino acids and others: valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, aspartic acid, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine. , Ornithine, histidine or derivatives thereof, and amino acids such as sulfates, phosphates, nitrates, citrates, or amino acid derivatives such as pyrrolidonecarboxylic acid.
Α-Hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids, polyhydroxycarboxylic acids or hydroxypolycarboxylic acids, lactobionic acid, photosensitizer No. 301, hinokithiol, pantothenic acid Alternatively, a derivative thereof, allantin, trimethylglycine, proteoglycan, and the like can be mentioned.

Antioxidants Antioxidants can be added to the present invention. Specific examples of antioxidants include ascorbic acid or a salt thereof and a derivative thereof, tocopherol or a salt thereof and a derivative thereof, tocotrienol or a salt thereof and a derivative thereof, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), and the like. Examples thereof include coenzyme Qn (n = 7 to 10), pyroquinolinquinone, propyl ascorbic acid, sesamol, carotenoids and the like.

Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to the present invention. Specific examples of active oxygen scavengers and radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and derivatives thereof, curcumin. Alternatively, salts thereof and derivatives thereof, transferase, celluloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothioneine, and the like can be mentioned.

Lipid metabolism promoter An lipid metabolism promoter can be added to the present invention. Specific examples of fat metabolism promoters include xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, cholineteophylline, diprophylline, proxiphyllin, oxtriphyllin, etc.), cocculus orbicula extract, cocculus orbicula extract, and cocculus orbicula. Examples thereof include (self-defense) extract, gajutsu (莪朮) extract, Karakusakeman extract, kikyo (kikyo, kikyo root) extract, kizuta extract, pepper (kosho) extract, and the like.

Anti-inflammatory agent An anti-inflammatory agent can be added to the present invention. Specific examples of anti-inflammatory agents include quinolinone derivatives, dibenzooxepine derivatives, thiotroposine, phthalimide derivatives, flurubiprofen, fervinac, bufexamac, sprofene, 1,4-diphenylpropylpiperazin derivatives, carxin compounds, chromanol glycosides ( 2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d-camfur, DL-camfur, salicylic acid, sodium salicylate, Methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, cremastine fumarate, cyproheptazine hydrochloride, promethazine hydrochloride, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or salts thereof and their salts. Derivatives, glycylic acid or salts thereof and derivatives thereof, mephenumic acid, phenylbutazone, ibprofen, ketoprofen, allantin, calcium pantothenate, pantenol such as pantothenyl ethyl ether and salts thereof and derivatives thereof, ε-aminocaproic acid, Examples thereof include sodium diclofenac, salicylic acid or a derivative thereof, sulfatide, chlorpheniramine maleate, diphenhydramine hydrochloride, and the like.

Blood flow promoter An blood flow promoter can be added to the present invention. Specific examples of blood flow enhancers include tocopherol or a salt thereof and a derivative thereof, tocotrienol or a salt thereof and a derivative thereof, cepharanthin, carpronium chloride, eugenol derivative, minoxidil, tincture tincture, vanylamide nonylate, cantalis tincture, ginger. Tincture, L-menthol, camphor, benzyl nicotinate, ictamol, α-borneol, valenylamide nonylate, capsaicin, senburi extract, garlic extract, carrot extract, gentian extract, touki extract, ginger extract, semburi (this drug) Extracts, etc. can be mentioned.

Testosterone 5α-reductase activity inhibitor / hair papilla activator / hair growth promoter To the present invention, testosterone 5α-reductase activity inhibitor / hair papilla activator / hair growth promoter can be added. Specific examples of testosterone 5α reductase activity inhibitor, hair papilla activator, and hair growth promoter include γ-amino-β-hydroxybutyric acid esters, amine oxides, alkyl betaines, pyrimidine-N-oxide derivatives, and acetylcarnitine. Alternatively, a salt thereof, geranylgeranyl acetone, a hydroxamic acid derivative or a salt thereof, proanthocyanidins, and the like can be mentioned.

Low molecular weight component In addition to the above-mentioned components, a low molecular weight component usually used for external preparations for skin such as cosmetics and pharmaceuticals may be added to the present invention. Low molecular weight components consist of one or more other aqueous components, oily components, plant extracts, animal extracts, powders, surfactants, oils, alcohols, pH adjusters, preservatives, thickeners, pigments, fragrances, etc. Consisting of ingredients, these are part of the base and can also serve as valuable resources due to their effects on the skin.

As the surfactant, a surfactant having an HLB value of 3.5 or more and 12 or less is desirable. When the HLB value is in this range, the pressure-sensitive adhesive is easily molded and the molded pressure-sensitive adhesive sheet feels good.
The content of the surfactant is 1% by mass or more and 20% by mass or less, preferably 2% by mass or more and 15% by mass or less with respect to the adhesive layer.

As the alcohol, a polyhydric alcohol is desirable for adjusting the viscosity of the coating liquid of the pressure-sensitive adhesive, and ethylene glycol, glycerin, propylene glycol, etc. are mentioned, and glycerin is preferable.
The content of the polyhydric alcohol is 0.2% by mass or more and 5% by mass or less, preferably 0.5% by mass or more and 3.0% by mass or less with respect to the adhesive layer.

Method for manufacturing the pressure-sensitive adhesive sheet The pressure-sensitive adhesive sheet is made by adding a plasticizer, a surfactant, etc. to the main ingredient, an acrylic pressure-sensitive adhesive (obtained in a state where the acrylic polymer is suspended in water or dissolved in an organic solvent), depending on the purpose. It is added, and a solvent (water or organic solvent) is further added for homogenization to prepare a coating liquid. The coating liquid is applied onto a PET release film so that the thickness after drying becomes a predetermined thickness, and dried at about 70 to 90 ° C. for about 10 minutes to obtain an adhesive sheet.
The support sheet can be used as it is when a polyolefin film, PET film or the like is used. When an acrylic resin is used as the support, the support sheet is obtained by a coating method similar to that for producing an adhesive sheet.
The obtained pressure-sensitive adhesive sheet can independently constitute the skin pressure-sensitive adhesive sheet of the present invention. Further, a laminated sheet obtained by laminating the obtained adhesive sheet and a support sheet is also included in the skin adhesive sheet of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the following examples. These examples are merely examples for specifically explaining the present invention, and the scope of the present invention is not limited to these examples.

Example 1
Adhesive sheets and support sheets were prepared and their properties were evaluated. Then, the adhesive sheet and the support sheet were laminated.
Preparation of adhesive sheet Acrylic ester emulsion type adhesive (Vinizol 1087FT, Daido Kasei Kogyo Co., Ltd., Iodosol GH800F (alkyl copolymer ammonium acrylate, AkzoNobel Co., Ltd.), and isopropyl myristate (Nakalitesk Co., Ltd.) as a plasticizer ), Octyldodecyl lactate (Esterol LOD, National Mimatsu Co., Ltd.), Aronbis AH-106X and glycerin as a solution viscosity adjuster, Saracos DG-15 as an emulsifier, and a coating solution. The coating liquid was cast on a PET film and dried by heating at 80 ° C. to obtain a pressure-sensitive adhesive sheet having a thickness of 40 μm. Table 1 illustrates the composition of the pressure-sensitive adhesive as Example 1-4. In Example 1, yodozol GH41F (alkyl acrylate copolymer ammonium, AkzoNobel Co., Ltd.) was used instead of yodozol GH800F.
All of the above compositions showed good adhesiveness.

Preparation of support sheet Separately, (styrene / alkyl acrylate) copolymer ammonium (Yodosol GH41F, AkzoNobel Co., Ltd.) and acrylic ester emulsion type pressure-sensitive adhesive (Vinizol 1087FT, Daido Kasei Kogyo Co., Ltd., Yodosol GH800F (acrylic acid) Alkyl copolymer ammonium, AkzoNobel Co., Ltd. was cast on a PET release film, dried by heating at 80 ° C. and peeled off from the PET release film to obtain a support sheet having a thickness of 30 μm. A comparative example was illustrated.
The adhesive sheet of Example 1 in Table 1 and the five types of support sheets in Table 2 were laminated to obtain an adhesive sheet with a support sheet. Examples 5 and 6 having a "hardness" value of 5.0 or more had high functionality as a support sheet when laminated with an adhesive sheet, but Comparative Example 1, Comparative Example 2, and Comparison In Example 3, the sheet was soft and did not function as a support sheet.

Table 3 summarizes the "hardness" and "IR strength ratio" of the adhesive and support used in Tables 1 and 2.

Preparation and functional evaluation of support films with surfactants with different HLB values (styrene / alkyl acrylate) Copolymer ammonium (Yodosol GH800F, AkzoNobel Co., Ltd.) Other components are cast on PET release film. Then, the pressure-sensitive adhesive sheet was molded by heating and drying at 80 ° C. Table 4 shows the results of determining the ease of casting on PET and the ease of molding into a sheet at that time.

Application of the adhesive sheet of the present invention 1. Cosmetic sheet for skin The adhesive sheet of the present invention is applied as a sheet for protecting facial skin, moisturizing, etc. without containing valuable skin resources in the adhesive layer.
2. Cosmetic sheet for skin The adhesive sheet of the present invention is applied as a sheet for protecting facial skin, moisturizing, whitening, promoting blood flow, etc. with skin valuables contained in the adhesive layer.
3. 3. Cosmetic sheet for skin The adhesive sheet of the present invention is applied as an adhesive sheet for lining a microneedle array with or without skin valuables contained in the adhesive layer.

As an application example of the above-mentioned skin cosmetic sheet, Table 5 shows the skin cosmetic sheet composition. In Example 12, VC ethylascorbic acid was used as a pigmentation inhibitor, in Example 13, trehalose was used as a moisturizer, in Example 14, tocopheryl retinoate as a metabolic activator, and in Example 15, antioxidant. A composition containing tocopherol as an agent, coenzyme Q10 as an active oxygen scavenger in Example 16, dipotassium glycyrrhizinate as an antioxidant in Example 17, and sembri extract as a blood flow promoter in Example 18. An example is shown. The skin cosmetic sheet compositions of Examples 12 to 18 were laminated and molded on the support sheet of Example 10.
The composition sheets of Examples 12 to 18 laminated on the support sheet all had a good feel of a decorative sheet.

As described in detail above, the adhesive sheet for skin of the present invention has an appropriate adhesiveness to the skin, and at the same time, it is possible to blend valuable skin resources, so that a cosmetic effect on the skin can be expected.

Claims

An adhesive sheet for skin containing an adhesive layer containing an acrylic resin having a "hardness" of 2.0 or less and / or an "IR strength ratio" of 2.0 or more.
The adhesive sheet according to claim 1, wherein the acrylic resin has a "hardness" of 2.0 or less and an "IR strength ratio" of 2.0 or more.
The pressure-sensitive adhesive sheet according to claim 1 or 2, wherein the acrylic resin is at least one selected from the group consisting of alkyl acrylate copolymer ammonium, alkyl acrylate / vinyl acetate copolymer and styrene / alkyl acrylate copolymer ammonium.
The pressure-sensitive adhesive sheet according to any one of claims 1 to 3, wherein the pressure-sensitive adhesive layer further contains a surfactant.
The pressure-sensitive adhesive sheet according to claim 4, wherein the surfactant is a surfactant having an HLB value of 3.5 or more and 12 or less.
The pressure-sensitive adhesive sheet according to claim 4 or 5, wherein the content of the surfactant is 1% by mass or more and 20% by mass or less.
The pressure-sensitive adhesive sheet according to any one of claims 1 to 6, wherein the pressure-sensitive adhesive layer further contains a polyhydric alcohol.
The adhesive sheet according to any one of claims 1 to 7, wherein the adhesive layer further contains valuable skin resources.
The adhesive sheet according to any one of claims 1 to 8, and a support sheet made of an acrylic resin having a "hardness" of 5.0 or more and an "IR strength ratio" of less than 2.0. Laminated adhesive sheet for skin made by laminating.