WO2021202131A1 - Désinfectants pour les mains utilisant des compositions d'alcool et de pyrithione de zinc - Google Patents

Désinfectants pour les mains utilisant des compositions d'alcool et de pyrithione de zinc Download PDF

Info

Publication number
WO2021202131A1
WO2021202131A1 PCT/US2021/023362 US2021023362W WO2021202131A1 WO 2021202131 A1 WO2021202131 A1 WO 2021202131A1 US 2021023362 W US2021023362 W US 2021023362W WO 2021202131 A1 WO2021202131 A1 WO 2021202131A1
Authority
WO
WIPO (PCT)
Prior art keywords
hand sanitizer
zinc pyrithione
alcohol
ethanol
water
Prior art date
Application number
PCT/US2021/023362
Other languages
English (en)
Inventor
Steven D. Jensen
Original Assignee
Cao Group, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cao Group, Inc filed Critical Cao Group, Inc
Publication of WO2021202131A1 publication Critical patent/WO2021202131A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Definitions

  • the present invention relates to the field of disinfectants and more particularly relates to a hand sanitizer containing a combination of alcohol and zinc pyrithione.
  • This patent relates to hand disinfection compositions. These compositions are designed to disinfect body parts, such as the hands and forearms by various application means such as: spray and air dry, pre-moistened wipes, spray and wipe, flooding, blotting, scrubbing with or without water, and other means of application.
  • Most contemporary hand disinfectants on the market are effective only in the short-term and are designed for an immediate anti-microbial effect at time of application.
  • Most contemporary hand disinfectants are designed to disinfect clean hands; but they are not designed to disinfect hands contaminated with biological fluids such as saliva, blood, sweat, feces, urine, and other contaminants. Many contaminants are not readily visible on ordinary surfaces, including hands, and the clinician may be completely unaware that a hand requires the physical removal of these contaminants before an any effective type of disinfection can occur.
  • the present invention is to provide hand disinfection compositions that are designed to disinfect contaminated hands and provide a long term bacteriostatic and/or bactericidal effect, especially through cumulative use.
  • the present invention represents a departure from the prior art in that the disinfectants of the present invention allows for the combination of alcohols and zinc pyrithione as a synergistic antagonist to combat microbes in both the short and long-term; and as an effective means to disinfect contaminated surfaces, including hands.
  • Prior hand sanitizer formulations that have used zinc pyrithione have done so as an inactive preservative, whereas this present invention utilizes much higher concentration of dissolved zinc pyrithione as a primary long-term disinfectant.
  • an improved disinfectant may comprise a combination of alcohols and zinc pyrithione to accomplish its disinfecting objective.
  • Figure 1 is a schematic showing the application of a hand sanitizer according to one embodiment of the present invention to a hand surface.
  • Figure 2 is a schematic showing the hand surface of FIG. 1 after treatment by the hand sanitizer.
  • Alcohols and zinc pyrithione work together providing an enhanced effect against microbes, especially on contaminated hands.
  • the alcohol provides fluid mobility and a powerful short-term anti-microbial effect while the zinc pyrithione provides a broad spectrum anti-microbial hand effect over a longer term, especially after cumulative use. Together they provide a synergistic effect against a broad spectrum of microorganisms such as bacteria, spores, viruses, yeasts, fungi, and other microorganisms, and especially against hands that are contaminated with biological fluids.
  • the present invention utilizes liquid alcohols such as methanol, ethanol, propanol, butanol, isopropanol, t-butyl alcohol, and all other fluidic alcohols that have antimicrobial activity.
  • the present invention utilizes the salts of pyrithione, especially the zinc salt.
  • Zinc pyrithione is an inorganic salt that is an excellent broad-spectrum antimicrobial even at very low concentrations.
  • zinc pyrithione is nearly insoluble in water, with a solubility of about 8ppm.
  • zinc pyrithione is an inorganic salt, it does not evaporate along with the volatile alcohol solutions and remains on the hand after application. It is this thinly disseminated layer (20) that provides a long-term antimicrobial effect that is directly tied to the amount of zinc pyrithione dissolved in an alcohol/water admixture (10).
  • the benefit is further enhanced by repeated use on a surface, such as a user’s skin (30), as the disseminated layer (20) slowly accumulates in density, thus providing an improved bacteriostatic effect.
  • Water is essential for life and does not in the general sense have antimicrobial properties; nevertheless, water can increase the antimicrobial efficiency of alcohols.
  • Water has a slower evaporation rate than many volatile alcohols and when an admixture of water and volatile alcohols are utilized as a hand disinfectant, the azeotrope formed allows the solution to evaporate at a slower rate. This provides a prolonged contact time with the skin and therefore a correspondingly higher microbe kill rate from exposure to the alcohol.
  • solutions of water and alcohol also follow a law of diminishing returns with respect to antimicrobial efficiency.
  • the resultant deposition layer of zinc pyrithione serves as the primary long-term disinfectant on the surface, rather than merely an inactive preservative.
  • An embodiment of the present invention prefers ethanol in the range of 85%-100%; with any remaining being water and/or other additives.
  • the most preferred range approaches 95% ethanol to 5% water and other additives.
  • An embodiment of the present invention prefers methanol in the range of 75%-100%; with any remaining being water, with the most preferred range being 90% methanol to 10% water and additives.
  • Another embodiment of the present invention prefers isopropanol in the range of 70%-100%; with any remaining being water, with the most preferred range being 70% isopropanol to 30% water and additives.
  • An embodiment of the present invention seeks to maximize:
  • An embodiment of the present invention is the utilization of the present invention to make a short and long-term hand sanitizer or sanitizing lotion; wherein the mixed solution of 95% ethanol with 5% water and an addition of 50ppm zinc pyrithione is thickened by the addition of various thickeners and emollients.
  • These thickeners and emollients can comprise various hydrogels, emulsions, suspensions, creams, and soluble gels.
  • thickeners and emollients are within the scope of this patent such as glycerin, PEG, propylene glycol, polyethylene oxide, carboxypolymethylene, PVP, xanthum gum, methoxycellulose, polyethyloxazoline, polyvinyl alcohol, agarose, methylcellulose, polysaccharides, pectin, guar gum, locust bean gum, carrageenan, agar-agar, gelatin, salts of alginic acid, fumed silica, clay, chalk, fumed aluminum oxide, and any other useful rheological modifiers and emollients.
  • thickeners and emollients are within the scope of this patent such as glycerin, PEG, propylene glycol, polyethylene oxide, carboxypolymethylene, PVP, xanthum gum, methoxycellulose, polyethyloxazoline, polyvinyl alcohol, agarose, methylcellulose, polysaccharides, pectin,
  • Thickeners can be blended with various combinations of ethanol and water that is saturated with soluble zinc pyrithione to create translucent gels.
  • the thickeners and emollients can be blended without the addition of alcohol and only zinc pyrithione utilized to form a suspension, lotion, or emulsion such that insoluble zinc pyrithione is suspended throughout the composition.
  • Another embodiment combines thickeners and emollients with alcohol, water, and insoluble zinc pyrithione to increase the amount of available zinc pyrithione in the suspension, lotion, or emulsion.
  • suspensions, lotions, hand sanitizers, emulsions are designed to provide short and long-term anti-microbial disinfection where it is applied onto the skin; and are formulated to be applied by hand until absorbed.
  • These suspensions, lotions, hand sanitizers, emulsions are loaded into various containers that protect the composition until it is ready to be dispensed by the customer as desired.
  • the present invention has industrial applicability as it is made by industry and has particular use in the medical and dental fields and in sanitization.
  • the present invention has been described with reference to preferred embodiments, numerous modifications and variations can be made and still the result will come within the scope of the invention. No limitation with respect to the specific embodiments disclosed herein is intended or should be inferred.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Désinfectant pour les mains présentant des propriétés améliorées pouvant comprendre un désinfectant fabriqué à partir de combinaisons d'eau, d'alcool, et de pyrithione de zinc. Le désinfectant peut être incorporé dans des lotions et d'autres formes pour créer un désinfectant pour les mains (10). Des concentrations élevées de pyrithione de zinc (20) dissoute sont obtenues par des concentrations plus élevées d'alcool. La solution résultante laisse une couche disséminée de pyrithione de zinc (20) qui agit comme désinfectant à long terme sur une surface traitée, dans ce cas les mains de l'utilisateur (30).
PCT/US2021/023362 2020-03-31 2021-03-20 Désinfectants pour les mains utilisant des compositions d'alcool et de pyrithione de zinc WO2021202131A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063002947P 2020-03-31 2020-03-31
US63/002,947 2020-03-31

Publications (1)

Publication Number Publication Date
WO2021202131A1 true WO2021202131A1 (fr) 2021-10-07

Family

ID=77928831

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/023362 WO2021202131A1 (fr) 2020-03-31 2021-03-20 Désinfectants pour les mains utilisant des compositions d'alcool et de pyrithione de zinc

Country Status (1)

Country Link
WO (1) WO2021202131A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493783A (en) * 1981-04-20 1985-01-15 Alcon Laboratories, Inc. Cleaning agent for optical surfaces
US6110908A (en) * 1995-03-31 2000-08-29 Guthery; B. Eugene Fast acting and persistent topical antiseptic
US20080045491A1 (en) * 2006-08-15 2008-02-21 Fitchmun Mark I Surface sanitizer
US20150258003A1 (en) * 2014-03-14 2015-09-17 Gojo Industries, Inc. Hand sanitizers with improved aesthetics and skin-conditing to encourage compliance with hand hygiene guidelines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493783A (en) * 1981-04-20 1985-01-15 Alcon Laboratories, Inc. Cleaning agent for optical surfaces
US6110908A (en) * 1995-03-31 2000-08-29 Guthery; B. Eugene Fast acting and persistent topical antiseptic
US20080045491A1 (en) * 2006-08-15 2008-02-21 Fitchmun Mark I Surface sanitizer
US20150258003A1 (en) * 2014-03-14 2015-09-17 Gojo Industries, Inc. Hand sanitizers with improved aesthetics and skin-conditing to encourage compliance with hand hygiene guidelines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M KARSHEVA, GEORGIEVA S, HANDJIEVA S: "THE CHOICE OF THE THICKENER -A WAY TO IMPROVE THE COSMETICS SENSORY PROPERTIES", 1 January 2007 (2007-01-01), pages 187 - 194, XP055128800, Retrieved from the Internet <URL:http://www.uctm.edu/journal/j2007-2/10-Kursheva_187-194.pdf> [retrieved on 20140714] *

Similar Documents

Publication Publication Date Title
US4941989A (en) Cleansing and disinfecting compositions
JP2638575B2 (ja) 皮膚消毒剤
US5767163A (en) Lubricating and/or germicidal composition
US5405602A (en) Nonaqueous cold sterilant
JP5587094B2 (ja) マイコバクテリアを制御するための、芳香族アルコールとグリセロールエーテルの混合液に基づく相乗的製剤
US5441723A (en) Non-toxic hypocompatible biodegradable germicide
WO1997029742A1 (fr) Composition lubrifiante et/ou germicide
JP2904917B2 (ja) 非毒性、非腐食性、生物分解性の消毒剤及び殺菌剤
US20060246120A1 (en) Antiseptic wipes
US5985929A (en) Cold chemical sterilant
US6015836A (en) Chemical disinfectant employing dual chain quaternary ammonium compounds with iodine
EP0609106A1 (fr) Une composition de glutaraldehyde
WO2021202131A1 (fr) Désinfectants pour les mains utilisant des compositions d&#39;alcool et de pyrithione de zinc
US5916568A (en) Flash-dry disinfectant solution for use as a hand wash
CA2430988A1 (fr) Lingette antimicrobienne
CN114515255A (zh) 杀菌消毒医用和普通消毒液及消毒湿巾溶液
WO2021173366A1 (fr) Désinfectants de surface à court et long terme utilisant des compositions d&#39;alcool et de pyrithione de zinc
Paulson Topical antimicrobials: classification and performance
WO1993017723A1 (fr) Desinfectant de surfaces biodegradable
BR102020010538A2 (pt) Produto e processo para a preparação de gel sanitizante de base aquosa
WO2022084713A1 (fr) Compositions contenant des composés métalliques pour la désinfection prolongée de surfaces et leurs utilisations
CN115279185A (zh) 胶束消毒剂
BR102020011430A2 (pt) Composição aplicada em protetor de superfícies com ação residual à base de álcool
CA2469547A1 (fr) Lingette antimicrobienne
TH2101000146A (th) องค์ประกอบของสารฆ่าเชื้อ (disinfectant composition)

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21780287

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21780287

Country of ref document: EP

Kind code of ref document: A1