WO2021185423A1 - Timbre de stimulation électrique du tissu cutané - Google Patents

Timbre de stimulation électrique du tissu cutané Download PDF

Info

Publication number
WO2021185423A1
WO2021185423A1 PCT/DK2021/050083 DK2021050083W WO2021185423A1 WO 2021185423 A1 WO2021185423 A1 WO 2021185423A1 DK 2021050083 W DK2021050083 W DK 2021050083W WO 2021185423 A1 WO2021185423 A1 WO 2021185423A1
Authority
WO
WIPO (PCT)
Prior art keywords
patch
layer
conductive
individual
battery
Prior art date
Application number
PCT/DK2021/050083
Other languages
English (en)
Inventor
Jan Jacobsen
Original Assignee
Lempré Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lempré Aps filed Critical Lempré Aps
Publication of WO2021185423A1 publication Critical patent/WO2021185423A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0464—Specially adapted for promoting tissue growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0468—Specially adapted for promoting wound healing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/52—Electrically conductive inks
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K3/00—Apparatus or processes for manufacturing printed circuits
    • H05K3/10—Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern
    • H05K3/12—Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using thick film techniques, e.g. printing techniques to apply the conductive material or similar techniques for applying conductive paste or ink patterns
    • H05K3/1241—Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using thick film techniques, e.g. printing techniques to apply the conductive material or similar techniques for applying conductive paste or ink patterns by ink-jet printing or drawing by dispensing
    • H05K3/125—Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using thick film techniques, e.g. printing techniques to apply the conductive material or similar techniques for applying conductive paste or ink patterns by ink-jet printing or drawing by dispensing by ink-jet printing
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/09—Use of materials for the conductive, e.g. metallic pattern
    • H05K1/092—Dispersed materials, e.g. conductive pastes or inks
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K2201/00—Indexing scheme relating to printed circuits covered by H05K1/00
    • H05K2201/10—Details of components or other objects attached to or integrated in a printed circuit board
    • H05K2201/10007—Types of components
    • H05K2201/10037—Printed or non-printed battery

Definitions

  • the present invention relates to biological human or animal patches which comprise one or more electrical current generators and contact means facilitating that electrical currents flow through the tissue which is in contact with the patch.
  • the stimulation of tissue with current is used to provide enhanced tissue regeneration.
  • EP2 804 662 It is known from EP2 804 662 to provide a tissue contact element through a membrane, which comprises a wired solid battery and a pat tern of contact points connected to each battery terminal.
  • the electrically conductive pattern is provided using precious metals such as gold, platin or silver.
  • a resistor of 1 k ohm is provided between the con ductive pattern and a battery terminal to keep the current low.
  • a mem brane is used between the tissue and the electrical circuit.
  • This system demands a wired high voltage battery with a large capacity to provide a long-term effect through the membrane, and such batteries are both heavy and bulky for persons using the tissue contact element to handle and accommodate near the contact element.
  • the batteries also demand wiring in order to facilitate connection between the battery terminals and the contact element.
  • US2004/0088036A1 discloses a device for surface stimulation of acu puncture points.
  • the device uses printed electronics that have access to the skin through holes in an adhesive layer.
  • the device is not intended nor suitable for long-term usage as it requires the user to stay still during the treatment, and therefore, a user would not be able to perform everyday activities while using the device.
  • the patch according to the invention is a patch for electrical stimulation of body tissue through the skin, wherein the patch comprises:
  • the battery has a thick ness of no more than 2 mm;
  • the area specific number of individual, electrically conductive areas is at least 3 per cm 2 .
  • the area specific number of individual, electrically conductive areas is at least 4 per cm 2 . In one embodiment, the area specific number of individual, electrically conductive areas is at least 5 per cm 2 . In one embodiment, the area specific number of individual, electrically conductive areas is at least 6 per cm 2 .
  • the area specific number of individual, electrically conductive areas is at least 7 per cm 2 .
  • the area specific number of individual, electrically conductive areas is at least 8 per cm 2 .
  • the area specific number of individual, electrically conductive areas is at least 9 per cm 2 .
  • the area specific number of individual, electrically conductive areas is at least 10 per cm 2 .
  • the typical pattern of the electrically conductive areas comprises a centrally arranged hole that is connected to one elec trical terminal, wherein a ring of holes is connected to a second electri cal terminal. This pattern is disadvantageous if the user's skin has an uneven distribution of conductivity as there is a risk that the current will flow to a single area. This can cause pain and in severe cases burns.
  • conductive gel is often used to ensure an even spread of current.
  • Each electrically conductive area is configured to establish electrical connection to the skin tissue.
  • the battery has a thickness of no more than 1.0 mm.
  • the battery has a thickness of no more than 0.5 mm.
  • the invention overcomes this disadvantage by ensuring that the area specific number of individual, electrically conductive area is sufficiently high to ensure that the current induced through the skin tissue will not be unintentionally focused on only a few conductive contact points.
  • the design of the invention also allows for easy customization of the patch in such a manner that it may be targeted at different parts of the body.
  • the human skin tissue varies in thickness and concentration of nerve cells density at the top skin, e.g. parts of extremities such as hands or feet may have a higher density of nerve cells present compared to cer tain areas of the back, which may have a lower density of nerve cells at the top skin.
  • the number of individual, electrically conductive areas is 10 or more.
  • the number of individual, electrically conductive areas is 12 or more.
  • the number of individual, electrically conductive areas is 14 or more.
  • the number of individual, electrically conductive areas is 16 or more.
  • the number of individual, electrically conductive areas 18 or more is not limited.
  • the substrate layer comprises silicon with a paper layer on top.
  • the conductive layer comprises conductive lines printed onto the substrate layer.
  • the printed conductive lines are arranged in one or more patterns, wherein each pattern is connected to a terminal in the battery.
  • each pattern is connected to a terminal in the battery.
  • a pattern is meant a specific way in which one or more lines are ar- ranged when printed onto the substrate. This is similar in nature to printed circuitry, except that the patterns are not connected to a switch (or another device) within the circuitry. The patterns are merely intend ed as a way to efficiently distribute the current over an area.
  • the conductive lines are printed in such a manner that the conductive lines form a first and a second pattern.
  • patterns are arranged into groups.
  • a group is meant an enclosed section of the patch, that comprises a pattern which forms a conductive connection with a battery terminal.
  • each individual conductive area inside the group is of the same polarity.
  • each individual group comprises the same number of individual, electrically conductive areas as their neighboring group.
  • neighboring group is meant a group that is connected to a battery terminal with a different polarity.
  • the number of individual, electrically conductive areas is the same for both electrical polarities (+ and -).
  • the electrically conductive areas are of each elec trical polarity are symmetrically arranged. By placing patterns within designated groups, it is easier to organize the design of the patches.
  • the patterns and the individual, electrically conduc tive areas are arranged in a manner such that the minimum distance between two adjacent individual, electrically conductive areas is in the range of 0.1 cm to 1 cm.
  • the minimum distance between two adjacent, indi vidual, electrically conductive areas is in the range of 0.1 cm to 0.5 cm.
  • the minimum distance between two adjacent, indi vidual, electrically conductive areas is in the range of 0.1 cm to 0.25 cm.
  • the minimum distance between two adjacent, indi vidual, electrically conductive areas is in the range of 0.5 cm to 2 cm.
  • the minimum distance between two adjacent, indi vidual, electrically conductive areas is in the range of 1 cm to 2 cm.
  • the minimum distance between two adjacent, indi vidual, electrically conductive areas is in the range of 1 cm to 5 cm.
  • the maximum distance between two adjacent, in dividual, electrically conductive areas is in the range 0.1-0.5 cm.
  • the maximum distance between two adjacent, in dividual, electrically conductive areas is in the range 0.1-0.3 cm.
  • the maximum distance between two adjacent, in dividual, electrically conductive areas is in the range 0.4-2 cm. In one embodiment, the maximum distance between two adjacent, in dividual, electrically conductive areas is in the range 0.5-3 cm.
  • the average distance between two adjacent, indi vidual, electrically conductive areas is in the range 0.1-0.2 cm.
  • the average distance between two adjacent, indi vidual, electrically conductive areas is in the range 0.2-0.4 cm.
  • the average distance between two adjacent, indi vidual, electrically conductive areas is in the range 0.4-0.5 cm.
  • the average distance between two adjacent, indi vidual, electrically conductive areas is in the range 0.5-1 cm.
  • the average distance between two adjacent, indi vidual, electrically conductive areas is in the range 1-2 cm.
  • the dispersion in distance between two adjacent, individual, electrically conductive areas is in the range 0.1-0.2 cm.
  • the dispersion in distance between two adjacent, individual, electrically conductive areas is in the range 0.2-0.3 cm.
  • the dispersion in distance between two adjacent, individual, electrically conductive areas is in the range 0.3-0.4 cm.
  • the dispersion in distance between two adjacent, individual, electrically conductive areas is in the range 0.4-0.5 cm.
  • the dispersion in distance between two adjacent, individual, electrically conductive areas is in the range 0.5-0.7 cm. In one embodiment, the dispersion in distance between two adjacent, individual, electrically conductive areas is in the range 0.7-1 cm.
  • the dispersion in distance between two adjacent, individual, electrically conductive areas is in the range 1-2 cm.
  • the integrated battery is placed adjacent to and in the same plane as the conductive layer.
  • the patch is placed adjacent to and in the same plane as the conductive layer.
  • the battery has a height of 0.1 mm or less. This allows for an overall, even profile of the patch, which reduces bulging and makes the patch more discreet to wear under for instance clothing.
  • the integrated battery has an area that is at least one tenth of the area of the conductive layer.
  • the integrated battery is placed in a layer sand wiched between the substrate and the conductive layer.
  • the conductive layer can be customized with much higher flexibility as the battery is not in the same plane.
  • the conductive layer comprises conductive blocks.
  • conductive block is meant a construction that is arranged and configured to be connected to a battery terminal and conducts cur rent throughout the construction.
  • the block is in contact with the openings in the adhesive layer constitute, individual electrically conductive areas.
  • Any material that can be conductive and produced in a relatively thin block would be suitable for producing a conductive block. While this so lution does not have the advantage of the printed conductive lines, it can provide a cheaper alternative as standard components can be used.
  • the invention comprises a patch which has a first pattern of individual, electrically conductive tissue contact areas, where each area is adapted to provide electric connection to a first electrical conductor, and a second pattern of individual, electrically conductive tissue contact areas, where each area is adapted to provide electric connection to a second electrical conductor, whereby each conductor is provided on a substrate.
  • conductor By the term conductor is meant the elements comprised in the conduc tive layer.
  • the conductor is a conductive printed line.
  • the invention further provides that the first and second patterns of individual, electrically conductive tissue contact are as are arranged adjacent to and/or below a battery element of no more than 0.5 mm thickness, and that the first and second conductors are in connection with each their battery terminal of the battery element.
  • a patch is provided, which has both the voltage source and the wiring and the connection points to a tissue element embedded in one integrated device. Accordingly, the device can easily be operated and applied to a tissue surface. This results in ease of wearing of such a device for days - without movement or activity restrictions. Thereby, the invention fulfils the objective of allowing the user to do as manyday-to-day activitiesas possible.
  • a patch of this type may provide pain relief, enhance recovery from tissue damage, enhance blood circu lation and combinations thereof.
  • the battery may be very thin according to the process by which it is manufactured. It may, thus, have a thickness below 0.1 mm and still provide the desired capacity. In an embodiment, a battery with a thick ness of no more than 0.1 mm is used.
  • the patch has printed conductive lines which are arranged in one layer and applied onto a substrate and further has a layer of tissue adhering adhesive provided on the layer of conductors and on the substrate.
  • the layer of tissue adhering adhesive is made from a non-conductive material, and thus serves the dual purpose of electrically insulating the conductors from the skin, and adhering the tissue contact element to tissue such as the skin of a user.
  • the layer of tissue adhering adhesive comprises a range of openings, whereby each opening is arranged in such a manner that there is direct, electrically conductive contact from the conductive layer to the underlying tissue through each opening.
  • the individual, conductive, tissue contact areas comprise simple openings in the adhesive layer.
  • This is a simple and straightfor ward way of providing the conductive, tissue contact areas with a direct contact between the conductive layer and the tissue. It also allows for a multitude of printed conductive lines, which are adapted to gain conduc tive contact with chosen tissue elements in a simple way.
  • a release layer is provided on top of the tissue ad hering adhesive so that the release layer is removable from the tissue adhering adhesive. This allows the patch to be both stored and trans- ported.
  • the release layer is electrically insulating, so that it is prevented that the electrically conductive tissue contact areas below the release layer gain any form of electrically conductive connection with each other or other elements during storage and/or transport of the tissue contact element. It also allows simple preparation of the tis- sue contact element, which is to be released from or peeled off the re lease layer and attached to an area of interest of the user.
  • the openings are arranged along a pattern of con ductive printed lines.
  • the openings are arranged to follow a pat- tern of conductive printed line.
  • the conductive printed lines are ar ranged to form a pattern on the substrate in order to minimize the re quired conductor material. This is not possible if the conductors are provided as larger areas.
  • the openings are arranged along the pattern of the conductive printed lines, it allows a wide range of various patterns of the openings and thus of individual, electrically conductive tissue contact areas to be provided with simple and effective means. Patterns fitting various parts of tissue may be easily provided, and even patterns that are individually fitted to a specific user may be generated with this arrangement.
  • the openings are circular. In one embodiment, the openings have a diameter that is no more than 20 percent larger than the width of the conductor lines and no more than 20 percent smaller than the width of the conductor lines. It is preferred that the width of the conductor lines does not deviate substantially from the diameter of the openings. This allows conductor lines to be utilized to the outmost.
  • the battery element is arranged on the substrate. This allows for a very thin and flexible device which is no more than 0.9 mm in thickness. A thickness down to 0.3 mm is preferred to allow for the desired flexibility and inconspicuous appearance, while durability and good connection between the battery terminals and the conductors are maintained. It is noted that the layer of adhesive also extends over the one side of the battery element so that this element also becomes attached to the skin as part of the patch.
  • the device can maintain a long battery lifetime, even when using a thin battery with a smaller capacity, as the output is distributed in a controlled manner.
  • the conductive lines are printed onto the substrate and comprise particles of silver or silver alloys.
  • the printing technique has been developed in recent years, and the addition of the silver to the print ink allows for well-defined resistance in the printed conductive lines. Any changes to the conductive lines are easily provided in order for customization and updates of the product.
  • the content of silver or silver alloy of the conductors is between 0.5 and 3.5 % by weight and most preferred between 1 and 2 % by weight. With this percentage of silver particles, a reasonable conductivity of the conductor lines is obtained. It is to be understood that patches with conductor lines which differ in conductivity may be provided in order to tailor conductivity in the conductor lines to the re sistance in the tissue of a user. Particularly when the tissue is skin, such as living skin, there are differences from person to person in skin con ductivity depending on age and on other factors.
  • the patch comprises a first section and second sec tion, wherein a first pattern is placed within the first section only, wherein a second pattern is placed within the second section only, wherein box-shaped area separates the first section and the second section.
  • the patch is a circular shape.
  • a patch without sharp corners can be provided, which provides long-term adhe sion.
  • the patch is produced in a flexible material in such a manner that the patch is not uncomfortable for the user even if placed upon a joint, such as an elbow.
  • Fig. 1 shows a patch seen from below
  • Fig. 2 shows two patches of different sizes, but each attached to a release layer of the same size
  • Fig. 3 shows a further embodiment of a patch according to the invention
  • Fig. 4 shows a patch according to the invention shown in a plane view
  • Fig. 5 shows a patch according to the invention
  • Fig. 6 shows a plane view of a patch according to the invention
  • Fig. 7 shows a sectional view of a substrate
  • Fig. 8 shows the substrate shown in Fig. 7 in a configuration, in which a conductive layer has been added
  • Fig. 9 shows the elements in Fig. 8 in a configuration, in which a layer of adhesive has been added
  • Fig. 10 shows the elements of Fig. 9 in a configuration, in which a release layer has been added and Fig. 11 shows a side view of a patch, wherein the battery element is placed adjacent to the conductive layer in the same plane.
  • a patch 2 of the pre sent invention is illustrated in Fig. 1.
  • the patch 2 comprises a number of layers, which are releasably attached to a release layer 22.
  • the user may thus peel the patch off the release layer 22 and place it onto tissue at an area where he/she wants the desired effect of the patch.
  • the patch 2 will provide electron contact to the tissue under neath it and to the surrounding tissue which will both absorb the elec trons.
  • the patch 2 comprises a pattern of individual, electrically conductive areas 4, 4', and, as seen in Fig. 1, each such contact area 4, 4 ' pro vides conductive access to the conductive printed lines 8, 12.
  • the conductive printed lines 8, 12 are provided on a substrate 14.
  • the conductive printed lines 8, 12 are print-applied onto the substrate, and this is done using standard printing techniques.
  • One known way of printing such conductors is to use an ink-jet printing technique with ink that has been made conductive by the addition of small particles of highly conductive metal, such as particles of metallic silver or silver al loy.
  • Alternative metallic particles are usable, such as particles of gold or titanium.
  • metals are somewhat more expensive than silver or silver alloys.
  • the conductive layer (not shown) comprises a con ductive block.
  • a conductive block is a construction that is arranged and configured to be connected to the integrated battery element 16 of the patch 2 in such a manner that current is conductive through the construction and hereby, along with the openings in the adhesive layer 20, it would con stitute individual, electrically conductive areas.
  • Any material that can be conductive and produced in a relatively thin block will be suitable for producing a conductive block.
  • the conductive, printed lines 8 are connected to the terminal 24 of a battery 16, and similarly, a second conductor 12 is connected to the second terminal 26 of the battery 16.
  • the conductive printed lines 8 are formed as a pattern 6 that ensures that the contact areas are evenly dispersed.
  • the conductive printed lines 12 are also formed as a pattern 10 that ensures that the contact areas 4 are evenly dispersed.
  • the two patterns 6, 10 are groups in such a manner that they are not intertwined, so that to each battery terminal 24, 26, a conductive contact is established to a well-defined group of individual, electrically conductive areas 4, 4'.
  • the individual, electrically conductive area 4 comprises holes in the skin adhesive layer 20, and they are arranged such that an evenly distribut ed amount of current is passed through the skin tissue of the user, re gardless of the position of the patch. This is done by selecting a pattern 4, 10 so that no area of the conductive area of the patch has an uneven distribution of contact areas 4.
  • a typical pattern has a central hole, connected to one terminal and then a ring of holes connected to a second terminal. If the user's skin has an uneven distribution of conductivity, there is a risk that current will flow to one location, which may cause pain and in se vere cases burns. To overcome this issue, a conductive gel is often used to ensure an even spread of current.
  • a patch with a diameter of 60 mm is shown, and the number 60 is displayed above the patch.
  • a patch with a diameter of 30 mm is shown, and the number 30 is shown above the patch.
  • the release paper 22 for the two patches has the same size, and is in this case shaped as a square with a side length of 70 mm and rounded corners.
  • Fig 3. shows an embodiment of a patch, which has the battery element 16 adjacent to the printed conductive lines 8, 12.
  • the conductive lines 8, 12 are, similar to Fig. 1, arranged in groups wherein each group has a first and a second pattern 6, 10 that are connected to a first and a second battery terminal 24, 26, respectively.
  • the openings comprising the individual, electrically conductive areas 4, 4 ' are slightly smaller than the width of the printed conductive lines 8, 12.
  • the embodiment shown in Fig. 3 has an approximate area specific number of the individual, electrically conductive area of 3 per cm 2 .
  • Fig. 4, Fig. 5 and Fig. 6 show various embodiments of the invention, wherein the patch is shaped in different manners.
  • Fig. 4 is a further embodiment of a patch shown in a plane view.
  • the two patterns 6, 10 are designed in such a way that the tissue contact areas 4 are intertwined, so that an individual, electri cally conductive area 4 belonging to one pattern 6 shall always have adjacent conductive areas belonging to another pattern 10.
  • the patch shown in Fig. 4 is somewhat elongate and has the battery 16 provided at one end thereof.
  • Such a patch may be ap plied to the skin of a finger or to the face, above or beneath an eye.
  • a patch is shown where the number of tissue contact areas is limited, and the first and second conductors are correspondingly short. This ensures that the battery over the number of tissue contact areas is large.
  • the battery may be made in many shapes, but it shall always have two terminals, i.e. a first terminal 24 and a second terminal 26. When no current is running from the first terminal 24 to the second terminal 26, the battery is to maintain a volt age difference between 0.0 and 3 volts depending on its charge state.
  • one tissue con tact area 4 at any group connected to a battery terminal has at least one neighbouring tissue contact area 4 which is connected to a battery terminal of opposite polarity.
  • the openings 20 should preferably not be smaller than the width of the conductor lines.
  • the openings are circular and have a diameter which is no more than 20 percent larger than the width of the conductor lines and no more than 20 percent smaller than the width of the conductor lines. As seen in Figs. 4, 5 and 6, the openings 20 are about the same diameter as the printed conductive lines width.
  • Fig 7-10 show a sectional view of the layers of the patch.
  • a sectional view, showing a substrate 14, is shown.
  • the sub strate may be any flexible sheet-formed element.
  • the substrate 14 shown in Fig. 7 is disclosed, and further more, a conductive layer is shown on top.
  • the con ductive layer consists of printed conductive lines 8.
  • the adhesive 18 is a non-conductive tissue adhesive of a usual composition, and as seen the adhesive layer 18 is provided with openings 20, so that the tissue may gain contact with the printed con ductive lines through the openings 20.
  • the tis sue adhering adhesive is 0.1 mm thin, so that contact between the tis sue and the conductor is easily obtained through the openings.
  • the openings are circular and have a diameter which is commensurate with the width of the underlying conductor line. This means that the open ings have a diameter in the range between 1 mm and 3 mm - and pref erably of 2.5 mm.
  • Each opening 20 is placed on top of a conductor, and the opening and underlying conductor thus provide the individual, elec trically conductive area 4.
  • the release layer may be paper or combinations fibrous material and various polymers.
  • the release layer is treated on the surface, with a muting layer, such as a wax or the like. The surface treatment ensures that the release layer easily can be peeled away from the adhesive layer. It is noted, as shown in Fig. 1, that the release layer 22 may be considerably larger than the patch, even if this is not shown in Fig. 10.
  • the battery element 16 is arranged on the substrate 14 in the embodi ments shown in Figs. 1-6. However, the battery may also be arranged in a separate layer (not shown).
  • Fig. 11 shows the battery element 16 being placed adjacent to the con ductive layer 8 on top of the substrate 14. As the limiting factor for the height is the height of the battery, this embodiment allows the device to be less than 1 cm in total height.
  • the printed conductive lines 8, 12 are printed onto the substrate by the use of conductive ink.
  • the conductivity of the ink is regulated by the use of metallic particles of silver or silver alloy, and the content of silver or silver alloy is arranged to be between 0.5 and 3.5 % by weight of the ink use. By experimenting, it has been determined that the best results are obtained with ink having a content of silver or silver alloy between 1 and 2 % by weight.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Timbre (2) de stimulation électrique du tissu cutané, le timbre (2) comprenant : - une couche formant substrat (14) ; - une couche conductrice (28), qui est fixée à la couche formant substrat ; - un élément de batterie (16) intégré dans le timbre, la batterie (16) ayant une épaisseur non supérieure à 0,5 mm ; - une couche adhésive (18) constituée d'un adhésif non conducteur, adhérant à la peau, la couche adhésive (18) étant fixée à la couche conductrice (28), la couche adhésive (18) comprenant une pluralité d'ouvertures (20), chaque ouverture (20) constituant une zone individuelle, électriquement conductrice (4, 4') ; le nombre spécifique de zones de zones individuelles, électriquement conductrices (4, 4') étant d'au moins 2 par cm2.
PCT/DK2021/050083 2020-03-17 2021-03-17 Timbre de stimulation électrique du tissu cutané WO2021185423A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA202000346 2020-03-17
DKPA202000346 2020-03-17

Publications (1)

Publication Number Publication Date
WO2021185423A1 true WO2021185423A1 (fr) 2021-09-23

Family

ID=75477850

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2021/050083 WO2021185423A1 (fr) 2020-03-17 2021-03-17 Timbre de stimulation électrique du tissu cutané

Country Status (1)

Country Link
WO (1) WO2021185423A1 (fr)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040088036A1 (en) 2001-03-20 2004-05-06 Gilbert Bruce R. Device for surface stimulation of acupuncture points
US20050085751A1 (en) * 2003-09-10 2005-04-21 Shalom Daskal Disposable electric bandage
US20050284752A1 (en) * 2004-06-28 2005-12-29 Zvi Nitzan Novel electrodes and uses thereof
US20080215128A1 (en) * 2005-02-01 2008-09-04 Rainey Christopher J Electrode arrangement for applying electrical signals to the skin of an animal
US20090043185A1 (en) * 2006-02-23 2009-02-12 Sensor Technology And Devices Ltd. Biomedical surface electrode
US20100228180A1 (en) * 2006-01-26 2010-09-09 Power Paper Ltd Power Source Electrode Treatment Device
EP2804662A1 (fr) 2012-01-16 2014-11-26 Texo Medical ApS Dispositif pour le traitement d'une plaie
WO2019119045A1 (fr) * 2017-12-22 2019-06-27 Ti2 Medical Pty Ltd Matériau anisotropiquement conducteur destiné à être utilisé avec une surface biologique
US20190308015A1 (en) * 2014-06-03 2019-10-10 Vomaris Innovations, Inc. Methods and devices for treating the skin

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040088036A1 (en) 2001-03-20 2004-05-06 Gilbert Bruce R. Device for surface stimulation of acupuncture points
US20050085751A1 (en) * 2003-09-10 2005-04-21 Shalom Daskal Disposable electric bandage
US20050284752A1 (en) * 2004-06-28 2005-12-29 Zvi Nitzan Novel electrodes and uses thereof
US20080215128A1 (en) * 2005-02-01 2008-09-04 Rainey Christopher J Electrode arrangement for applying electrical signals to the skin of an animal
US20100228180A1 (en) * 2006-01-26 2010-09-09 Power Paper Ltd Power Source Electrode Treatment Device
US20090043185A1 (en) * 2006-02-23 2009-02-12 Sensor Technology And Devices Ltd. Biomedical surface electrode
EP2804662A1 (fr) 2012-01-16 2014-11-26 Texo Medical ApS Dispositif pour le traitement d'une plaie
US20190308015A1 (en) * 2014-06-03 2019-10-10 Vomaris Innovations, Inc. Methods and devices for treating the skin
WO2019119045A1 (fr) * 2017-12-22 2019-06-27 Ti2 Medical Pty Ltd Matériau anisotropiquement conducteur destiné à être utilisé avec une surface biologique

Similar Documents

Publication Publication Date Title
US6745082B2 (en) Current-controlling electrode with adjustable contact area
US5354321A (en) Patch arrangement for galvanic treatment
US4736752A (en) Transcutaneous medical electrode
US6134480A (en) Electrode assembly
US6907299B2 (en) Electrodes for a transcutaneous electrical nerve stimulator
CN105451805B (zh) 生物医学电极极板
US6038485A (en) Current-controlling electrode
US8320988B2 (en) Multi-electrode strung on a common connector
US5380271A (en) Electrotransport agent delivery device and method
US7324847B2 (en) Reverse current controlling electrode
EP2340080B1 (fr) Electrode en forme de chaîne
US4011861A (en) Implantable electric terminal for organic tissue
US9962538B2 (en) Multi-electrode with lateral conductivity control
US5456710A (en) Vented electrode
EP1421971A3 (fr) Electrode de stimulation transcutanée transparente aux rayons X
JP2017108758A (ja) 生体用電気刺激デバイスと生体用電気刺激装置
US4265253A (en) Skin conducting electrode and electrode assembly
WO2021185423A1 (fr) Timbre de stimulation électrique du tissu cutané
US9089684B2 (en) Dual-sided current controlling electrode
JP6725124B1 (ja) 生体電池治療具
EP4094801A1 (fr) Appareil médical à batterie biogalvanique
IES960223A2 (en) An electrode

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21718014

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21718014

Country of ref document: EP

Kind code of ref document: A1