WO2021176426A1 - Systems and methods for detecting an intentional leak characteristic curve for a respiratory therapy system - Google Patents

Systems and methods for detecting an intentional leak characteristic curve for a respiratory therapy system Download PDF

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Publication number
WO2021176426A1
WO2021176426A1 PCT/IB2021/051884 IB2021051884W WO2021176426A1 WO 2021176426 A1 WO2021176426 A1 WO 2021176426A1 IB 2021051884 W IB2021051884 W IB 2021051884W WO 2021176426 A1 WO2021176426 A1 WO 2021176426A1
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WIPO (PCT)
Prior art keywords
value
flow rate
breath
values
user
Prior art date
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Ceased
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PCT/IB2021/051884
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English (en)
French (fr)
Inventor
Stephen Mcmahon
Anna RICE
Graeme Alexander LYON
Redmond Shouldice
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Resmed Sensor Technologies Ltd
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Resmed Sensor Technologies Ltd
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Publication date
Application filed by Resmed Sensor Technologies Ltd filed Critical Resmed Sensor Technologies Ltd
Priority to JP2022553698A priority Critical patent/JP7446463B2/ja
Priority to US17/801,096 priority patent/US11724051B2/en
Priority to AU2021230446A priority patent/AU2021230446B2/en
Priority to EP21711375.2A priority patent/EP4114486B1/en
Priority to EP24171322.1A priority patent/EP4378506A3/en
Priority to CN202180032966.1A priority patent/CN115485003B/zh
Publication of WO2021176426A1 publication Critical patent/WO2021176426A1/en
Anticipated expiration legal-status Critical
Priority to US18/211,716 priority patent/US20230330375A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/60—Muscle strain, i.e. measured on the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/63—Motion, e.g. physical activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/65—Impedance, e.g. conductivity, capacity

Definitions

  • the second nominal pressure value is different from the first nominal pressure value.
  • a second plurality of flow rate values for the second time period is generated.
  • a second Cartesian coordinate is generated.
  • the second Cartesian coordinate has a second X value based on at least a second flow rate value of the second plurality of flow rate values.
  • the second Cartesian coordinate has a second Y value based at least on the second nominal pressure value. Based at least in part on the generated first Cartesian coordinate and the generated second Cartesian coordinate, an intentional leak characteristic curve associated with the respiratory therapy system is determined.
  • a computer program product comprising instructions which, when executed by a computer, cause the computer to carry out any one of the methods disclosed above.
  • the computer program product is a non-transitory computer readable medium.
  • FIG. 4C illustrates pressure data associated with a user of a respiratory therapy system with an expiratory pressure relief module, according to some implementations of the present disclosure.
  • FIG. 11 illustrates an intentional leak characteristic curve fitted for a scatter plot of pressure values (“P”; cmH20) versus flow rate values (“Q”; liters per 10s), according to some implementations of the present disclosure.
  • the user interface 124 may form a seal, for example, with a region or portion of the user’ s face, to facilitate the delivery of gas at a pressure at sufficient variance with ambient pressure to effect therapy, for example, at a positive pressure of about 10 cmFhO relative to ambient pressure.
  • the user interface may not include a seal sufficient to facilitate delivery to the airways of a supply of gas at a positive pressure of about 10 cmFhO.
  • the display device 128 acts as a human-machine interface (HMI) that includes a graphic user interface (GUI) configured to display the image(s) as an input interface.
  • HMI human-machine interface
  • GUI graphic user interface
  • the display device 128 can be an LED display, an OLED display, an LCD display, or the like.
  • the input interface can be, for example, a touchscreen or touch-sensitive substrate, a mouse, a keyboard, or any sensor system configured to sense inputs made by a human user interacting with the respiratory therapy device 122.
  • the analyte sensor 174 can also be used to detect whether the user 210 is breathing through their nose or mouth. For example, if the data output by an analyte sensor 174 positioned near the mouth of the user 210 or within the facial mask (in implementations where the user interface 124 is a facial mask) detects the presence of an analyte, the control system 110 can use this data as an indication that the user 210 is breathing through their mouth.
  • the physiological data from the activity tracker 180 can be used to determine, for example, a number of steps, a distance traveled, a number of steps climbed, a duration of physical activity, a type of physical activity, an intensity of physical activity, time spent standing, a respiration rate, an average respiration rate, a resting respiration rate, a maximum he respiration art rate, a respiration rate variability, a heart rate, an average heart rate, a resting heart rate, a maximum heart rate, a heart rate variability, a number of calories burned, blood oxygen saturation, electrodermal activity (also known as skin conductance or galvanic skin response), or any combination thereof.
  • the activity tracker 180 is coupled (e.g., electronically or physically) to the user device 170.
  • FIG. 3A illustrates a breath waveform of a person while sleeping, according to some implementations of the present disclosure.
  • the horizontal axis is time, and the vertical axis is respiratory flow rate.
  • an example breathing cycle may have the following approximate values: tidal volume Vt 0.5L, inhalation time Ti 1.6s, peak inhalation flow rate Qpeak 0.4 L/s, exhalation time T e 2.4s, peak exhalation flow rate Qpeak -0.5 L/s.
  • the total duration of the breathing cycle, Ttot is about four (4) seconds.
  • An individual typically breathes at a rate of about 15 breaths per minute (BPM), with Minute Ventilation about 7.5 L/min.
  • BPM breaths per minute
  • Minute Ventilation about 7.5 L/min.
  • the ratio of Ti to Ttot is about 40%.
  • the respiratory flow rate Qr averages to zero over a plurality of respiratory cycles (e.g., breathing cycles), because the average respiratory flow rate into or out of the lungs must be zero. Taking tilde ( ⁇ ) to indicate the average value over the plurality of respiratory cycles:
  • the resulting parameters h and ki may then be compared to a data structure of pairs ⁇ ki, ki) associated with known user interface types to identify the user interface or access data for operations of the respiratory therapy device that is associated with use of particular user interfaces.
  • the intentional leak characteristic curve is calculated using the equation: where Z is the intentional leak characteristic curve (e.g., indicative of the impedance), P is a pressure value of the plurality of pressure values, Q is a flow rate value of the plurality of flow rate values, / is a first constant, and k 2 is a second constant.
  • the first constant / may be associated with the turbulent flow; the second constant k 2 may be associated with the laminar flow.
  • the formula (12) is advantageous because the impedance can be calculated using a linear equation.

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  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
PCT/IB2021/051884 2020-03-06 2021-03-05 Systems and methods for detecting an intentional leak characteristic curve for a respiratory therapy system Ceased WO2021176426A1 (en)

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JP2022553698A JP7446463B2 (ja) 2020-03-06 2021-03-05 呼吸療法装置の意図的なリーク特性曲線を検出するシステムおよび方法
US17/801,096 US11724051B2 (en) 2020-03-06 2021-03-05 Systems and methods for detecting an intentional leak characteristic curve for a respiratory therapy system
AU2021230446A AU2021230446B2 (en) 2020-03-06 2021-03-05 Systems and methods for detecting an intentional leak characteristic curve for a respiratory therapy system
EP21711375.2A EP4114486B1 (en) 2020-03-06 2021-03-05 Systems and methods for detecting an intentional leak characteristic curve for a respiratory therapy system
EP24171322.1A EP4378506A3 (en) 2020-03-06 2021-03-05 Systems and methods for detecting an intentional leak characteristic curve for a respiratory therapy system
CN202180032966.1A CN115485003B (zh) 2020-03-06 2021-03-05 用于检测呼吸治疗系统的有意泄漏特性曲线的系统和方法
US18/211,716 US20230330375A1 (en) 2020-03-06 2023-06-20 Systems and methods for detecting an intentional leak characteristic curve for a respiratory therapy system

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