WO2021175898A1 - Medical treatment device and method for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof - Google Patents

Medical treatment device and method for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof Download PDF

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Publication number
WO2021175898A1
WO2021175898A1 PCT/EP2021/055278 EP2021055278W WO2021175898A1 WO 2021175898 A1 WO2021175898 A1 WO 2021175898A1 EP 2021055278 W EP2021055278 W EP 2021055278W WO 2021175898 A1 WO2021175898 A1 WO 2021175898A1
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WO
WIPO (PCT)
Prior art keywords
patient
acoustic
stimulating
medical treatment
treatment device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2021/055278
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English (en)
French (fr)
Other versions
WO2021175898A9 (en
Inventor
Peter Alexander Tass
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gretap AG
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Gretap AG
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Filing date
Publication date
Application filed by Gretap AG filed Critical Gretap AG
Priority to US17/905,428 priority Critical patent/US12616833B2/en
Priority to ES21709953T priority patent/ES3039258T3/es
Priority to JP2022552460A priority patent/JP7522481B2/ja
Priority to EP21709953.0A priority patent/EP4114510B1/en
Priority to CN202180018982.5A priority patent/CN115335114A/zh
Publication of WO2021175898A1 publication Critical patent/WO2021175898A1/en
Publication of WO2021175898A9 publication Critical patent/WO2021175898A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/008—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms using shock waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • A61H23/0245—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with ultrasonic transducers, e.g. piezoelectric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/01—Constructive details
    • A61H2201/0157—Constructive details portable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/12—Driving means
    • A61H2201/1207—Driving means with electric or magnetic drive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/1604—Head
    • A61H2201/1607—Holding means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2205/00—Devices for specific parts of the body
    • A61H2205/02—Head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0022—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the tactile sense, e.g. vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0066—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with heating or cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0072—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/08—Supports for equipment
    • A61M2209/088—Supports for equipment on the body

Definitions

  • the stimulation unit 12 is configured to generate tactile or vibratory stimuli, also referred to vibrotactile stimuli, to be administrated to corresponding receptors in the patient’s skin, in particular in the head region of the patient.
  • the human skin comprises different types of mechanoreceptive afferent units capable of sensing tactile or vibratory stimuli.
  • the distribution and density of the different types of mechanoreceptors differs in dependence on the position on the human skin.
  • Each stimulating element 14a-d is actuated at a substantially constant and the same actuation frequency vi- 4 during the sequence C. Specifically, when being actuated by the control unit 16, a first stimulating element 14a is operated at a first actuation frequency vi, a second stimulating element 14 is operated at the second actuation frequency V2, a third stimulating element 14c is operated at a third actuation frequency V3 and a fourth stimulating element 14d is operated at a fourth actuation frequency V 4 .
  • the stimulation unit 12 may be configured such that the actuating frequencies vi- 4 , i.e. the individual members of the set of actuation frequencies, are adjusted to a pentatonic scale. In this way, particularly acceptable, smooth and/or relaxing acoustic stimulus sequences may be provided. Further, pentatonic frequencies may provide the advantageous effect that they can be smoothly combined. Specifically, the stimulation unit 12 may be provided with a set of different actuation frequencies vi-5 which constitute at least a part of the pentatonic scale.
  • the first stimulating elements 20a-d are actuated at an actuation frequency v' which dependence on the actuation frequency v of their associated second stimulating elements 22a-d.
  • each first stimulating element 20a-d may be actuated at an actuation frequency v' which is equal to or which constitutes a harmonic of the actuation frequency v of its associated second stimulating element 22a-d.
  • the actuation frequency v' of each first stimulating element 20a-d may be 1/m or m/1 of the actuation frequency v of its associated second stimulating element 22a-d, wherein m is a natural number greater than 1 .
  • the stimulation unit may be provided with a set of different actuation frequencies.
  • This set of actuating frequencies may include actuating frequencies, in particular predefined actuating frequencies, at which the at least one stimulating element can be actuated.
  • the stimulating elements may be configured to be actuated at the actuating frequencies comprised in the set of actuating frequencies. Accordingly, the stimulating elements may be not allowed to be operated at actuation frequencies which are not comprised in the set of actuating frequencies.
  • the set of actuation frequencies may comprise a first actuating frequency and at least one further actuating frequency which is determined in dependence on or correlates to the first actuating frequency. In this way, upon determining the first actuating frequency, also the at least one further actuating frequency may be determined.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Hospice & Palliative Care (AREA)
  • Social Psychology (AREA)
  • Psychiatry (AREA)
  • Physics & Mathematics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Acoustics & Sound (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Electrotherapy Devices (AREA)
  • Finger-Pressure Massage (AREA)
PCT/EP2021/055278 2020-03-03 2021-03-03 Medical treatment device and method for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof Ceased WO2021175898A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US17/905,428 US12616833B2 (en) 2021-03-03 Medical treatment device and method for stimulating neurons of a patent to suppress a pathologically synchronous activity thereof
ES21709953T ES3039258T3 (en) 2020-03-03 2021-03-03 Medical treatment device for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof
JP2022552460A JP7522481B2 (ja) 2020-03-03 2021-03-03 患者のニューロンを刺激してニューロンの病的同期活動を抑制する医療用治療装置及び方法
EP21709953.0A EP4114510B1 (en) 2020-03-03 2021-03-03 Medical treatment device for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof
CN202180018982.5A CN115335114A (zh) 2020-03-03 2021-03-03 用于刺激患者的神经元以抑制其病理性同步活动的医疗设备和方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062984454P 2020-03-03 2020-03-03
US62/984,454 2020-03-03

Publications (2)

Publication Number Publication Date
WO2021175898A1 true WO2021175898A1 (en) 2021-09-10
WO2021175898A9 WO2021175898A9 (en) 2022-02-03

Family

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PCT/EP2021/055278 Ceased WO2021175898A1 (en) 2020-03-03 2021-03-03 Medical treatment device and method for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof

Country Status (5)

Country Link
EP (1) EP4114510B1 (https=)
JP (1) JP7522481B2 (https=)
CN (1) CN115335114A (https=)
ES (1) ES3039258T3 (https=)
WO (1) WO2021175898A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2630139A (en) * 2023-05-19 2024-11-20 Charco Neurotech Ltd Strap arrangement for use with wearable devices for mitigating symptoms of neurological conditions of users

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011127918A1 (de) * 2010-04-12 2011-10-20 Forschungszentrum Jülich GmbH Vorrichtung und verfahren zur konditionierten desynchronisierenden nicht-invasiven stimulation
WO2013158208A2 (en) * 2012-04-17 2013-10-24 Regents Of The University Of Minnesota Multi-modal synchronization therapy
US20190200888A1 (en) * 2017-12-31 2019-07-04 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
WO2019243634A1 (en) 2018-06-22 2019-12-26 Gretap Ag Medical treatment device and method for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012002436B4 (de) * 2012-02-08 2014-08-21 Forschungszentrum Jülich GmbH Vorrichtung zur Eichung einer nicht-invasiven desynchronisierenden Neurostimulation
DE202013006065U1 (de) * 2013-07-05 2013-09-12 Anm Adaptive Neuromodulation Gmbh Vorrichtung zur akustischen Stimulation mit einer adaptiven dynamischen Stimulationssignalkonditionierung
DE102014115994B4 (de) * 2014-11-03 2016-12-22 Forschungszentrum Jülich GmbH Vorrichtung zur effektiven invasiven desynchronisierenden Neurostimulation
PL3865102T3 (pl) * 2015-11-17 2024-12-16 Neuromod Devices Limited Urządzenie i sposób leczenia zaburzeń neurologicznych układu słuchowego

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011127918A1 (de) * 2010-04-12 2011-10-20 Forschungszentrum Jülich GmbH Vorrichtung und verfahren zur konditionierten desynchronisierenden nicht-invasiven stimulation
WO2013158208A2 (en) * 2012-04-17 2013-10-24 Regents Of The University Of Minnesota Multi-modal synchronization therapy
US20190200888A1 (en) * 2017-12-31 2019-07-04 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
WO2019243634A1 (en) 2018-06-22 2019-12-26 Gretap Ag Medical treatment device and method for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2630139A (en) * 2023-05-19 2024-11-20 Charco Neurotech Ltd Strap arrangement for use with wearable devices for mitigating symptoms of neurological conditions of users

Also Published As

Publication number Publication date
CN115335114A (zh) 2022-11-11
JP7522481B2 (ja) 2024-07-25
JP2023516050A (ja) 2023-04-17
EP4114510B1 (en) 2025-06-25
WO2021175898A9 (en) 2022-02-03
EP4114510A1 (en) 2023-01-11
ES3039258T3 (en) 2025-10-20
US20230264018A1 (en) 2023-08-24

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