WO2021158083A1 - Dispositif de traitement de partie affectée utilisant une réaction d'oxydo-réduction - Google Patents

Dispositif de traitement de partie affectée utilisant une réaction d'oxydo-réduction Download PDF

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Publication number
WO2021158083A1
WO2021158083A1 PCT/KR2021/001592 KR2021001592W WO2021158083A1 WO 2021158083 A1 WO2021158083 A1 WO 2021158083A1 KR 2021001592 W KR2021001592 W KR 2021001592W WO 2021158083 A1 WO2021158083 A1 WO 2021158083A1
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Prior art keywords
electrode
oxidation
electrode pattern
reduction reaction
electrode material
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PCT/KR2021/001592
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English (en)
Korean (ko)
Inventor
정민웅
강성구
장명훈
Original Assignee
바이오센서연구소 주식회사
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Priority claimed from KR1020200135397A external-priority patent/KR102551684B1/ko
Application filed by 바이오센서연구소 주식회사 filed Critical 바이오센서연구소 주식회사
Publication of WO2021158083A1 publication Critical patent/WO2021158083A1/fr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive bandages or dressings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive bandages or dressings
    • A61F13/0203Adhesive bandages or dressings with fluid retention members
    • A61F13/0213Adhesive bandages or dressings with fluid retention members the fluid retention member being a layer of hydrocolloid, gel forming material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0468Specially adapted for promoting wound healing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00727Plasters means for wound humidity control
    • A61F2013/00748Plasters means for wound humidity control with hydrocolloids or superabsorbers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00902Plasters containing means
    • A61F2013/00919Plasters containing means for physical therapy, e.g. cold or magnetic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/0436Material of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Definitions

  • the present invention relates to a device for treating a diseased area using an oxidation-reduction reaction.
  • the materials used in the treatment of burns and wounds should be able to reduce the period of wound healing by epithelialization, to have no discomfort due to bleeding or pain during replacement, and to minimize scar formation after epithelialization. In addition, it should be readily available due to its low secondary infection rate and easy manufacturing and storage. Based on this, in order to promote wound healing, moist wound healing is applied to the wound and used as various biological dressings, and it has an effect of helping epithelial regeneration.
  • bands are used to treat wounds on the skin. These bands can be broadly divided into two types. One is a band that is used by applying a therapeutic ointment to the wounded skin and then attached to the wound to prevent secondary bacterial infection, and the other is the cell of the wounded area. In order to prevent scars from occurring due to abnormal cell expression due to inability to move healing cells around the wound due to drying after contact with air, a porous organic material containing a large amount of water is attached to the wound area to provide moisture. It is a band that prevents necrotic tissue while allowing it to be released slowly.
  • the general dry dressing method is to disinfect the wounded area on the skin and then block it from the outside to prevent secondary infection so that the wound does not spread and heal the wound.
  • the hydrophilic polymer absorbs the exudate generated from the wound and suppresses the rapid evaporation of moisture to create a moist atmosphere in the wound area. It has the function of helping wound healing and minimizing scars by facilitating the flow of healing cells and ions that have a positive effect on healing.
  • An object of the present invention is to provide an apparatus for treating an affected area using an oxidation-reduction reaction capable of recovering a wound by forming a current or an electric field by an oxidation-reduction reaction in a wound area.
  • these problems are exemplary, and the scope of the present invention is not limited thereto.
  • One aspect of the present invention is a base sheet, an electrode unit attached to the base sheet and having electrode materials having different polarities, and an electrode material attached to the base sheet and activated to electrically connect the electrode materials by the absorbed exudate It provides a device for treating an affected area using an oxidation-reduction reaction having an absorption layer.
  • the device for treating an affected area using an oxidation-reduction reaction is electrically activated when attached to the affected area, so that the affected area can be quickly and safely restored.
  • the absorbent member absorbs the exudate or the like
  • electrode materials having different polarities are electrically activated to emit electrons to the affected area and form an electric field.
  • the affected area can be recovered quickly and safely by electrical stimulation, and scarring can be minimized because the wound treatment device using the oxidation-reduction reaction maintains a wet state.
  • the device for treating the affected area using the oxidation-reduction reaction according to the present invention generates electrical stimulation only when attached to the affected area, thereby securing the safety and predictability of the dressing device, and stably providing the electrical stimulation to the affected area.
  • FIG. 1 is a view showing an apparatus for treating an affected area using an oxidation-reduction reaction according to a first embodiment of the present invention.
  • FIG. 2 is a cross-sectional view of an apparatus for treating an affected area using an oxidation-reduction reaction attached to the affected area.
  • 3A and 3B are modified examples of the device for treating the affected area using the oxidation-reduction reaction of FIG. 1 .
  • 4A to 4E are other modified examples of the device for treating an affected area using the oxidation-reduction reaction of FIG. 1 .
  • FIG. 5 is a view showing an apparatus for treating an affected area using an oxidation-reduction reaction according to a second embodiment of the present invention.
  • FIG. 6 is a cross-sectional view of an apparatus for treating an affected area using the oxidation-reduction reaction of FIG. 5 attached to the affected area.
  • 7A and 7B are modified examples of the device for treating the affected area using the oxidation-reduction reaction of FIG. 5 .
  • FIG. 8 is a view showing an apparatus for treating an affected area using an oxidation-reduction reaction according to a third embodiment of the present invention.
  • FIG. 9 is a cross-sectional view of an apparatus for treating an affected area using the oxidation-reduction reaction of FIG.
  • FIG. 10 is a diagram illustrating an apparatus for treating an affected area using an oxidation-reduction reaction according to a fourth embodiment of the present invention.
  • FIG. 11 is a view showing an apparatus for treating an affected area using an oxidation-reduction reaction according to a fifth embodiment of the present invention.
  • FIG. 12 is a view showing an apparatus for treating an affected area using an oxidation-reduction reaction according to a sixth embodiment of the present invention.
  • FIG. 13 is a view showing an apparatus for treating an affected area using an oxidation-reduction reaction according to a seventh embodiment of the present invention.
  • FIG. 14 is a view showing an apparatus for treating an affected area using an oxidation-reduction reaction according to an eighth embodiment of the present invention.
  • 15A to 15D are modified examples of the device for treating an affected area using the oxidation-reduction reaction of FIG. 14 .
  • 16 is a diagram illustrating a method for treating an affected area using an oxidation-reduction reaction according to another embodiment of the present invention.
  • 17 is a photograph comparing the treatment effect using the device for treating the affected area using the oxidation-reduction reaction according to the present invention.
  • One aspect of the present invention is a base sheet, an electrode unit attached to the base sheet and having electrode materials having different polarities, and an electrode material attached to the base sheet and activated to electrically connect the electrode materials by the absorbed exudate It provides a device for treating an affected area using an oxidation-reduction reaction having an absorption layer.
  • the electrode unit is provided with at least one first electrode pattern disposed on one side of the base sheet, and at least one second electrode pattern provided with at least one and spaced apart from the first electrode pattern.
  • the electrode unit may have a first electrode pattern forming a closed curve along the base sheet, and a second electrode pattern disposed inside the first electrode pattern.
  • the absorption layer is disposed to cover the first electrode pattern and the second electrode pattern, or is disposed to be spaced apart between the first electrode pattern and the second electrode pattern, the first electrode pattern by the absorbed exudate and the second electrode pattern.
  • the absorbent layer may include a hydrocolloid or polyurethane.
  • Another aspect of the present invention is an oxidation- comprising a base sheet and an absorption unit attached to the base sheet, wherein an electrode material in particle form is mixed in an absorbent member, and the electrode material is activated when exudate is absorbed by the absorbent member;
  • an apparatus for treating an affected area using a reduction reaction is provided.
  • a first electrode material and a second electrode material activated with different polarities may be disposed inside the absorption member.
  • the absorption unit includes a first absorption layer in which a first electrode material is disposed inside the absorption member, and a second absorption layer in which a second electrode material having a polarity different from that of the first electrode material is disposed inside the absorption member.
  • the first absorption layer and the second absorption layer may be alternately stacked.
  • the first absorption layer and the second absorption layer may be disposed adjacent to each other on the base sheet.
  • the absorption unit may further include a third absorption layer disposed between the first absorption layer and the second absorption layer, the third absorption layer not including the electrode material and having the absorption member.
  • the absorbent member may include a hydrocolloid or polyurethane.
  • Another aspect of the present invention is a base sheet, a first electrode pattern formed of a first electrode material disposed on the base sheet, and a particle shape disposed on the base sheet and having a polarity different from that of the first electrode material
  • an apparatus for treating an affected area using an oxidation-reduction reaction comprising an absorbent unit having an absorbent member in which a second electrode material is mixed.
  • the absorption unit may electrically connect the first electrode material and the second electrode material when the exudate is absorbed by the absorption member.
  • the absorption unit may be disposed to be spaced apart from the first electrode pattern and, when activated, may extend to contact the first electrode pattern.
  • a second electrode pattern disposed to be spaced apart from the first electrode pattern and formed of the second electrode material may be further included.
  • the absorption unit may further include the first electrode material in the form of particles mixed with the absorption member.
  • the absorbent member may include a hydrocolloid or polyurethane.
  • an apparatus for treating an affected area using an oxidation-reduction reaction is an apparatus using an electric current generated in the oxidation-reduction reaction.
  • a disease treatment device using an oxidation-reduction reaction forms a relatively low level electric field (LLEF) when the oxidation-reduction reaction is activated, or a relatively low level micro-current (LLMC) ) that forms the device.
  • the device for treating the affected area using the oxidation-reduction reaction can increase the recovery rate of the affected area with electrical energy generated by the oxidation reaction and the reduction reaction of a galvanic cell.
  • activation is defined as the supply of electric current in the device for treating an affected area using an oxidation-reduction reaction. Specifically, it is defined as electrode materials having different polarities are electrically connected to each other, so that electrons and ions move.
  • the affected part (W) is attached to a device using reverse electrodialysis and oxidation-reduction reaction, and is a target for delivering drugs or receiving electrical stimulation to the skin using an electrical reaction, for example, animal skin or human skin.
  • an electrical reaction for example, animal skin or human skin.
  • both the base sheet and the skin EP may have conductivity, so the electrons may move through any one of the affected area W, the skin, and the treatment device for the affected area.
  • FIG. 1 is a view showing an apparatus 100 for treating an affected area using an oxidation-reduction reaction according to a first embodiment of the present invention, and FIG. It is a cross section.
  • an oxidation-reduction treatment device 100 using a reduction reaction may include a base sheet 110 , an electrode unit 120 , an absorption layer 130 , and a release film 140 .
  • the base sheet 110 has a preset thickness formed so as to be attached to the affected part W of the object, and may be made of a sheet having flexibility. One surface of the base sheet 110 is in close contact with the skin of the object, and the other surface is exposed to the outside.
  • the base sheet 110 may have various sizes and shapes according to the position of the object to be attached.
  • the base sheet 110 may have various shapes such as a circle, a square, a rectangle, a triangle, and the like.
  • the base sheet 110 has a rectangular shape.
  • the base sheet 110 may be formed of a material having biocompatibility.
  • the base sheet 110 is a part that is attached to the skin of the object, and may be formed of a safe material that does not cause trouble on the skin even if it is attached for a long time.
  • the base sheet 110 may be a medical band applicable to a medical dressing.
  • the electrode unit 120 is attached to the base sheet 110 and may have an electrode material having a polarity.
  • the electrode unit 120 may have a first electrode pattern 121 and a second electrode pattern 122 having different polarities.
  • At least one first electrode pattern 121 may be provided, and may be disposed on one side of the base sheet 110 .
  • the first electrode pattern 121 may include a first electrode material.
  • the first electrode pattern 121 may extend along one side of the base sheet 110 .
  • At least one second electrode pattern 122 may be provided, and may be disposed to be spaced apart from the first electrode pattern 121 .
  • the second electrode pattern 122 may include a second electrode material.
  • the second electrode pattern 122 may extend along the other side of the base sheet 110 .
  • the first electrode pattern 121 and the second electrode pattern 122 may be disposed at the edge of the absorption layer 130 .
  • the first electrode pattern 121 and the second electrode pattern 122 are disposed on the edge of the affected area W, the absorption layer 130 covers the upper portion of the affected area W, and the first electrode pattern is absorbed by the exudate. 121 and the second electrode pattern 122 may be activated.
  • the first electrode pattern 121 and the second electrode pattern 122 are attached to one surface of the base sheet 110 , and the absorption layer 130 is formed with the first electrode pattern 121 and It may be disposed on the base sheet 110 to cover the second electrode pattern 122 . Since the first electrode pattern 121 and the second electrode pattern 122 are attached to the base sheet 110 , the electrode unit 120 is not separated from the base sheet 110 , and durability may be improved.
  • the first electrode pattern 121 and the second electrode pattern 122 may have different polarities.
  • the first electrode pattern 121 may include a first electrode material
  • the second electrode pattern 122 may include a second electrode material having a polarity different from that of the first electrode material.
  • the first electrode pattern 121 may be formed by using only the first electrode material or by mixing the first electrode material and another material.
  • the second electrode pattern 122 may also be formed by using only the second electrode material or by mixing the first electrode material and another material.
  • the first electrode material and the second electrode material are not limited to a specific material, and may be defined as a material capable of forming another electrode by a potential difference. Also, the first electrode material and the second electrode material may be formed of a material having biocompatibility. However, hereinafter, for convenience of description, a case where the first electrode material is silver chloride (AgCl) and the second electrode material is zinc (Zn) will be mainly described.
  • the first electrode pattern 121 is a cathode electrode
  • the second electrode pattern 122 is an anode electrode. If silver chloride (AgCl) is used as the cathode electrode and zinc (Zn) is used as the anode electrode, an oxidation-reduction reaction is generated as follows.
  • AgCl silver chloride
  • Zn zinc
  • the absorption layer 130 is attached to the base sheet 110 and may be activated to electrically connect the electrode material by the absorbed exudate EXD.
  • the absorbent layer 130 may absorb exudate EXD such as moisture or ooze generated from the wound, and the absorbed exudate EXD may activate the electrode unit 120 .
  • the absorption layer 130 may be disposed on one surface of the base sheet 110 . In one embodiment, as shown in FIG. 2 , at least a portion of the electrode unit 120 may be disposed inside the absorption layer 130 . The absorption layer 130 may be disposed to cover the first electrode pattern 121 and the second electrode pattern 122 .
  • the absorption layer 130 does not activate the electrode unit 120 in a dry state, but may activate the electrode unit 120 in a wet state. That is, the absorption layer 130 does not electrically activate the electrode unit 120 when the device 100 for treating the affected area using the oxidation-reduction reaction is not used. However, when the wound treatment device 100 using the oxidation-reduction reaction is attached to the affected area W, the exudate EXD is absorbed by the absorbent member of the absorption layer 130, and as described above, the first electrode pattern 121 and the second electrode pattern 122 are electrically activated.
  • the absorbing layer 130 may include an absorbing member.
  • the absorbent member may be defined as a material that absorbs the exudate EXD generated in the affected part W.
  • the absorbent member may include hydrocolloid or polyurethane.
  • the absorbent layer 130 may further include a drug that helps wound healing.
  • the drug may act on the affected area (W) to accelerate the recovery of the wound.
  • the release film 140 may be removed when using the device 100 for treating an affected area using an oxidation-reduction reaction, and may be disposed to cover the absorbent layer 130 . In order to prevent the absorbent layer 130 from being infected, the release film 140 may be attached to the upper surface of the absorbent layer 130 .
  • the apparatus 100 for treating an affected area using an oxidation-reduction reaction is electrically activated when attached to the affected area, so that the affected area can be quickly and safely restored.
  • the absorbent member absorbs the exudate and the like
  • electrode materials having different polarities are electrically activated, and emit electrons to the affected area to generate a current and form an electric field.
  • electrical stimulation the affected area can be recovered quickly and safely, and scarring can be minimized since the wound area treatment apparatus 100 using an oxidation-reduction reaction maintains a wet state.
  • the device 100 for treating an affected area using an oxidation-reduction reaction generates electrical stimulation only when attached to the affected area, so that the safety and predictability of the dressing device can be secured, and the electrical stimulation can be stably can be provided to the affected area.
  • 3A and 3B are modified examples of the device for treating the affected area using the oxidation-reduction reaction of FIG. 1 .
  • the electrode unit 120-1 of the device 100-1 for treating an affected area using an oxidation-reduction reaction may be disposed to be exposed on the upper surface of the absorption layer 130 .
  • the first electrode pattern 121-1 and the second electrode pattern 122-1 may be disposed on the upper surface of the absorption layer 130 .
  • first electrode pattern 121-1 and the second electrode pattern 122-1 may be disposed to be depressed in the absorption layer 130 as shown in FIG. 3A . In another embodiment, the first electrode pattern 121-1 and the second electrode pattern 122-1 may be disposed to protrude from the absorption layer 130 .
  • the electrode unit ( 120-1) can be activated quickly.
  • the electrode unit 120 - 2 of the apparatus 100 - 2 for treating an affected area using an oxidation-reduction reaction may be disposed to be included in the absorption layer 130 .
  • the first electrode pattern 121 - 2 and the second electrode pattern 122 - 2 may be disposed in the inner space of the absorption layer 130 .
  • the wound treatment apparatus 100-2 using the oxidation-reduction reaction is stably supported, and the electrode The unit 120 - 2 can be activated quickly.
  • 4A to 4E are other modified examples of the device for treating an affected area using the oxidation-reduction reaction of FIG. 1 .
  • the electrode unit 120A may be disposed on the front surface of the absorption layer 130 .
  • the first electrode pattern 121A and the second electrode pattern 122A each extend to a predetermined length and may be alternately disposed.
  • a plurality of the first electrode pattern 121A and the second electrode pattern 122A may be disposed to be spaced apart from each other at a predetermined interval over the entire surface of the absorption layer 130 .
  • the first electrode pattern 121A and the second electrode pattern 122A are disposed over the entire surface of the absorption layer 130, so that a uniform current is applied over the entire area of the affected area. provided, and a constant electric field can be formed in the affected area.
  • the electrode unit 120B may be disposed on the front surface of the absorption layer 130 .
  • the first electrode pattern 121B and the second electrode pattern 122B may each have a predetermined size and may be alternately disposed.
  • the first electrode pattern 121B and the second electrode pattern 122B are provided in a dot shape, and a plurality of them may be alternately disposed and spaced apart from each other at a predetermined interval over the entire surface of the absorption layer 130 .
  • the first electrode pattern 121B and the second electrode pattern 122B are disposed over the entire surface of the absorption layer 130, so that a uniform current is applied over the entire area of the affected area. provided, and a constant electric field can be formed in the affected area.
  • the apparatus 100C for treating an affected area using an oxidation-reduction reaction has a first electrode pattern 121C having a closed curve, and a second electrode pattern 122C disposed in the first electrode pattern 121C.
  • the first electrode pattern 121C may extend along the edge of the absorption layer 130 to form a closed-loop.
  • the second electrode pattern 122C is disposed to be spaced apart from the first electrode pattern 121C, has a predetermined area and may have a dot shape.
  • the apparatus 100D for treating an affected area using an oxidation-reduction reaction has a first electrode pattern 121D having a closed curve, and a second electrode pattern 122D disposed within the first electrode pattern 121D.
  • the first electrode pattern 121D may extend along the edge of the absorption layer 130 to form a closed circuit.
  • the second electrode pattern 122D may be disposed to be spaced apart from the first electrode pattern 121D, and may extend along the first electrode pattern 121D with a predetermined width and length.
  • the device 100E for treating an affected area using an oxidation-reduction reaction has a first electrode pattern 121E disposed on both sides and a second electrode pattern 122E disposed between the first electrode pattern 121E.
  • the first electrode pattern 121E may be disposed on the edge of the absorption layer 130
  • the second electrode pattern 122E may be disposed on the center of the absorption layer 130 .
  • the wound treatment device using the oxidation-reduction reaction is spaced apart from the first electrode pattern and the second electrode pattern is arranged at a set position, by setting the direction of the current to recover the wound in a preset direction there is. This will be described in detail with reference to FIG. 16 below.
  • FIG. 5 is a view showing an apparatus 200 for treating an affected area using an oxidation-reduction reaction according to a second embodiment of the present invention
  • FIG. 6 is an apparatus for treating an affected area using the oxidation-reduction reaction of FIG. 5 attached to the affected area ( 200) is a cross section.
  • the device 200 for treating an affected area using an oxidation-reduction reaction may include a base sheet 210 , an electrode unit 220 , and an absorption layer 230 .
  • the base sheet 210 and the electrode unit 220 are substantially the same as the base sheet 110 and the electrode unit 120 of the first embodiment described above.
  • the absorption layer 230 will be mainly described.
  • the absorption layer 230 may be disposed to be spaced apart from the electrode unit 220 .
  • the first electrode pattern 221 and the second electrode pattern 222 may be spaced apart from each other.
  • an edge of the absorption layer 230 may be disposed to be spaced apart from the first electrode pattern 221 and the second electrode pattern 222 by a predetermined distance G.
  • the absorbent layer 230 may expand to extend into the first electrode pattern 221 and the second electrode pattern 222 .
  • the absorption layer 230 forms an extended region EP in contact with the first electrode pattern 221 and the second electrode pattern 222 .
  • the first electrode pattern 221 and the second electrode pattern 222 may be electrically activated by the extended region EP.
  • the extended area EP may be defined as an area in which the absorbent member of the absorbent layer 230 absorbs the exudate EXD and has an enlarged area.
  • the first electrode pattern 221 and the second electrode pattern 222 may be included in the extension region EP to connect the first electrode pattern 221 and the second electrode pattern 222 .
  • the absorbent layer 230 protrudes from the base sheet 210 to have a predetermined thickness, but when the exudate EXD is absorbed, the absorbent layer 230 may expand and decrease in thickness. That is, when the exudate EXD is absorbed, the absorbent member expands laterally to reduce the thickness of the absorbent layer 230 , and the expanded region EP may be generated.
  • the apparatus 200 for treating the affected area using the oxidation-reduction reaction according to the second embodiment of the present invention is electrically activated when attached to the affected area, so that the affected area can be quickly and safely restored.
  • the absorbent member absorbs exudate or the like
  • the absorbent layer may be expanded and electrically activated. Due to the expanded absorption layer, the electrode material emits electrons to the affected area and can form an electric field, so the affected area can be quickly and safely recovered by electrical stimulation.
  • the lesion treatment device 200 using the oxidation-reduction reaction covers the lesion and maintains a wet state, scarring can be minimized.
  • the device 200 for treating an affected area using an oxidation-reduction reaction generates electrical stimulation only when attached to the affected area, so that the safety and predictability of the dressing device can be secured, and the electrical stimulation can be stably can be provided to the affected area.
  • 7A and 7B are modified examples of the device for treating the affected area using the oxidation-reduction reaction of FIG. 5 .
  • an oxidation-reduction treatment apparatus 200A using a reduction reaction has an electrode unit 220A having a plurality of first electrode patterns 221A and a second electrode pattern 222A, and each first electrode pattern An absorption layer 230A may be disposed between the 221A and the second electrode pattern 222A.
  • the absorption layer 230A may be spaced apart from the first electrode pattern 221A by the first gap g1 and spaced apart from the second electrode pattern 222A by the second gap g2 .
  • the first gap g1 and the second gap g2 may be set differently or may be set the same.
  • the plurality of absorption layers 230A are disposed to be spaced apart from each other by the electrode unit 220A, and when the exudate EXD is absorbed, they may be integrally connected. Accordingly, electrical stimulation may be generated over the entire extended area EP.
  • the lesion treatment apparatus 200B using an oxidation-reduction reaction includes a first electrode pattern 221B in which the electrode unit 220B has a closed curve, and a first electrode pattern 221B disposed inside the first electrode pattern 221B. It may have a two-electrode pattern 222B.
  • the absorption layer 230 is disposed between the first electrode pattern 221 and the second electrode pattern 222 , but does not contact each other.
  • the absorbent member of the absorbent layer 230 absorbs the exudate EXD, the absorbent layer 230 may extend to the extended region EP, and electrical stimulation may be formed in the extended region EP.
  • FIG. 8 is a view showing an apparatus 300 for treating an affected area using an oxidation-reduction reaction according to a third embodiment of the present invention
  • FIG. 9 is a cross-sectional view of the apparatus 300 for treating an affected area using the oxidation-reduction reaction of FIG. am.
  • the apparatus 300 for treating an affected area using an oxidation-reduction reaction may include a base sheet 310 , an absorption unit 320 , and a release film 330 .
  • the base sheet 310 and the release film 330 are substantially the same as the base sheet 110 and the release film 140 of the first embodiment described above.
  • the absorption unit 320 is the center of the to explain
  • the absorption unit 320 is attached to the base sheet 310 , and the electrode material in the form of particles is mixed in the absorption member AM.
  • the absorption unit 320 may be formed in a layered structure on the base sheet 310 .
  • the absorption unit 320 is activated with different polarities and includes a first electrode material EL1 and a second electrode material EL2 having a particle shape.
  • the first electrode material EL1 and the second electrode material EL2 have particle shapes and are disposed to be mixed in the absorption member AM.
  • the absorption unit 320 is not electrically activated during storage, but when it is attached to the affected part W, the exudate EXD is absorbed by the absorption member AM to electrically activate the electrode material, so that electrons move or an electric field is formed.
  • the first electrode material EL1 and the second electrode material EL2 are not limited to a specific material, and may be defined as a material capable of forming another electrode due to a potential difference. However, hereinafter, for convenience of description, a case where the first electrode material EL1 is silver chloride (AgCl) and the second electrode material is zinc (Zn) will be mainly described. Accordingly, the first electrode material EL1 is a cathode electrode, and the second electrode material EL2 is set as an anode electrode, and an oxidation-reduction reaction is generated as follows.
  • the absorbent member AM may include hydrocolloid or polyurethane. However, in the following, an embodiment in which the absorbent member AM is a hydrocolloid will be mainly described.
  • the absorbing unit 320 mixes the first electrode material EL1 in the absorbing member AM, and mixes the second electrode material EL2 in another absorbing member AM, and includes two absorbing members.
  • the first electrode material EL1 and the second electrode material EL2 may be mixed with the absorbing member AM by mixing the members AM with each other.
  • the absorption unit 320 may be formed by mixing the first electrode material EL1 with the absorption member AM and then adding the second electrode material EL2 . Thereafter, the absorption unit 320 may be attached to the base sheet 310 by laminating, screen printing, tape casting, or the like.
  • the apparatus 300 for treating the affected area using the oxidation-reduction reaction according to the third embodiment of the present invention is electrically activated when attached to the affected area, so that the affected area can be quickly and safely restored.
  • the absorbent member absorbs the exudate
  • the first electrode material and the second electrode material in the form of particles may be electrically activated.
  • electrons are emitted to the affected area, an electric field is formed, and the affected area can be quickly and safely recovered by electrical stimulation.
  • Oxidation-reduction treatment device 300 using a redox reaction according to the third embodiment of the present invention by generating electrical stimulation only when attached to the affected area, it is possible to secure the safety and predictability of the dressing device, and stably electrical stimulation can be given to the affected area.
  • the first electrode material and the second electrode material in the form of particles are randomly arranged, it is possible to increase the electrical activity. Since the first electrode material and the second electrode material in the form of particles are randomly disposed over the entire affected area, when the exudate is absorbed, the electrode materials can react quickly to provide electrical stimulation to the affected area.
  • FIG. 10 is a diagram illustrating an apparatus 400 for treating an affected area using an oxidation-reduction reaction according to a fourth embodiment of the present invention.
  • the apparatus 400 for treating an affected area using an oxidation-reduction reaction may include a base sheet 410 and an absorption unit 420 .
  • the base sheet 410 is substantially the same as the base sheet 110 of the first embodiment described above.
  • the absorption unit 420 will be mainly described.
  • the absorption unit 420 may include a first absorption layer 421 and a second absorption layer 422 .
  • the first electrode material EL1 in the form of particles is disposed on the absorbing member AM
  • the second absorbing layer 422 includes the second electrode material EL2 in the form of particles on the absorbing member AM. This is placed
  • the first absorbing layer 421 and the second absorbing layer 422 are disposed adjacent to the base sheet 410 and alternately disposed with each other.
  • the second absorption layer 422 may be disposed between the pair of first absorption layers 421
  • the first absorption layer 421 may be disposed between the pair of second absorption layers 422 .
  • the first absorption layer 421 and the second absorption layer 422 may be disposed to contact each other.
  • the first absorbing layer 421 and the second absorbing layer 422 may be disposed to be spaced apart from each other by a predetermined distance.
  • the first electrode material of the first absorption layer 421 and the second The second electrode material of the absorption layer 422 may be electrically connected to form an electrical stimulation in the affected area (W).
  • FIG. 11 is a diagram illustrating an apparatus 500 for treating an affected area using an oxidation-reduction reaction according to a fifth embodiment of the present invention.
  • the apparatus 500 for treating an affected area using an oxidation-reduction reaction may include a base sheet 510 and an absorption unit 520 .
  • the base sheet 510 is substantially the same as the base sheet 110 of the first embodiment described above.
  • the absorption unit 520 will be mainly described.
  • the absorption unit 520 may include a first absorption layer 521 , a second absorption layer 522 , and a third absorption layer 523 .
  • the absorbing member AM is mixed with the first electrode material EL1 in the form of particles
  • the absorbing member AM is mixed with the second electrode material EL2 in the form of particles. This is mixed.
  • the third absorbing layer 523 is disposed between the first absorbing layer 521 and the second absorbing layer 522 .
  • the third absorbing layer 523 includes only the absorbing member AM and does not include an electrode material.
  • the third absorbing layer 523 may be formed of only the absorbing member AM to implement an electrical bridge function.
  • the first electrode material (EL1) of the first absorption layer 521 and the second electrode material EL2 of the second absorption layer 522 may be electrically connected to each other to form an electrical stimulation in the affected part W.
  • the third absorption layer 523 may rapidly electrically connect the first absorption layer 521 and the second absorption layer 522 .
  • FIG. 12 is a diagram illustrating an apparatus 600 for treating an affected area using an oxidation-reduction reaction according to a sixth embodiment of the present invention.
  • an apparatus 600 for treating an affected area using an oxidation-reduction reaction may include a base sheet 610 and an absorption unit 620 .
  • the base sheet 610 is substantially the same as the base sheet 110 of the first embodiment described above.
  • the absorption unit 620 will be mainly described.
  • the absorption unit 620 may include a first absorption layer 621 and a second absorption layer 622 , and the first absorption layer 621 and the second absorption layer 622 may be alternately disposed.
  • the absorbing member AM is mixed with the first electrode material EL1 in the form of particles
  • the absorbing member AM is mixed with the second electrode material EL2 in the form of particles. This is mixed.
  • the first absorbing layer 621 and the second absorbing layer 622 are disposed adjacent to each other on the base sheet 610 and alternately disposed with each other.
  • first absorbing layer 621 and the second absorbing layer 622 may be disposed to be spaced apart from each other at a predetermined interval as shown in FIG. 12 . In another embodiment, the first absorbing layer 621 and the second absorbing layer 622 may be disposed to be in contact with each other.
  • the exudate EXD is absorbed by the first absorbing layer 621 and the second absorbing layer 622, and the first absorbing layer 621 and The second absorbing layers 622 are connected to each other and are electrically active.
  • a plurality of absorption layers may be alternately disposed, and a particle-form first electrode material and a second electrode material may be mixed in each absorption layer.
  • the absorbent unit 620 in the absorption unit 620, a plurality of absorption layers are alternately disposed, the specific gravity of the first electrode material in the first absorption layer is greater than the specific gravity of the second electrode material, and the second electrode material in the second absorption layer.
  • the specific gravity may be greater than the specific gravity of the first electrode material.
  • FIG. 13 is a diagram illustrating an apparatus 700 for treating an affected area using an oxidation-reduction reaction according to a seventh embodiment of the present invention.
  • an apparatus 700 for treating an affected area using an oxidation-reduction reaction may include a base sheet 710 and an absorption unit 720 .
  • the base sheet 710 is substantially the same as the base sheet 110 of the first embodiment described above.
  • the absorption unit 720 will be mainly described.
  • the absorption unit 720 includes a first absorption layer 721 and a second absorption layer 722 , and the first absorption layer 721 and the second absorption layer 722 may be alternately stacked.
  • the absorbing member AM is mixed with the first electrode material EL1 in the form of particles
  • the absorbing member AM is mixed with the second electrode material EL2 in the form of particles. This is mixed.
  • the first absorption layer 721 and the second absorption layer 722 may be alternately stacked on one surface of the base sheet 710 .
  • FIG. 13 shows that the first absorbing layer 721 and the second absorbing layer 722 are stacked one by one, it is not limited thereto and may have a multi-layered structure.
  • the first electrode material (EL1) of the first absorption layer 721 and the second electrode material EL2 of the second absorption layer 722 may be electrically connected to each other to form an electrical stimulus in the affected part W.
  • the apparatus 700 for treating the affected area using the oxidation-reduction reaction can effectively provide electrical stimulation to the affected area to which the electrical stimulation should be provided after a predetermined period of time has elapsed.
  • FIG. 14 is a diagram illustrating an apparatus 800 for treating an affected area using an oxidation-reduction reaction according to an eighth embodiment of the present invention.
  • the apparatus 800 for treating an affected area using an oxidation-reduction reaction may include a base sheet 810 , a first electrode pattern 820 , and an absorption unit 830 .
  • the base sheet 810 is substantially the same as the base sheet 110 of the first embodiment described above.
  • the first electrode pattern 820 and the absorption unit 830 will be mainly described. .
  • the first electrode pattern 820 and the absorption unit 830 may each include electrode materials having different polarities.
  • the first electrode pattern 820 is disposed on one side of the base sheet 810 and may include a first electrode material EL1 .
  • the absorption unit 830 is disposed on the base sheet 810 and includes a second electrode material EL2 having a polarity different from that of the first electrode material EL1 , and includes a second electrode material in the form of particles on the absorption member AM. (EL2) may be arranged to be mixed.
  • the absorption unit 830 is disposed to cover the first electrode pattern 820 , and when the exudate EXD is absorbed by the absorption member AM, the first electrode material EL1 and the second electrode material EL2 are electrically connected to each other. can be activated with
  • the first electrode material and the second electrode material are not limited to a specific material, and may be defined as a material capable of forming another electrode by a potential difference.
  • the first electrode material EL1 is silver chloride (AgCl) and the second electrode material is zinc (Zn) will be mainly described.
  • the first electrode material EL1 is a cathode electrode
  • the second electrode material EL2 is an anode electrode, and an oxidation-reduction reaction is generated as follows.
  • the lesion treatment device 800 using an oxidation-reduction reaction When the lesion treatment device 800 using an oxidation-reduction reaction is attached to the lesion W, the exudate EXD is absorbed by the absorbent member AM, and the first electrode material EL1 of the first electrode pattern 820 .
  • the second electrode material EL2 in the form of hyperparticles is electrically activated. Since the oxidation-reduction treatment device 800 using the redox reaction generates a current and an electric field by the generated electrons, it is possible to provide electrical stimulation to the affected area.
  • the apparatus 800 for treating an affected area using an oxidation-reduction reaction is electrically activated when attached to the affected area, so that the affected area can be quickly and safely restored.
  • the absorbent member absorbs the exudate
  • the first electrode material and the second electrode material in the form of particles may be electrically activated.
  • electrons are emitted to the affected area, an electric field is formed, and the affected area can be quickly and safely recovered by electrical stimulation.
  • the device 800 for treating the affected area using the oxidation-reduction reaction generates electrical stimulation only when attached to the affected area, so that the safety and predictability of the dressing device can be secured, and the electrical stimulation can be stably can be given to the affected area.
  • the electrode material in the form of particles is randomly arranged, it is possible to increase the electrical activity.
  • the position of the first electrode material is fixed in a predetermined pattern, and the second electrode material in the form of particles is randomly disposed over the entire affected area.
  • the respective electrode materials are rapidly activated to provide electrical stimulation to the affected area, thereby effectively treating the wound.
  • 15A to 15D are modified examples of the device for treating an affected area using the oxidation-reduction reaction of FIG. 14 .
  • the apparatus 800A for treating an affected area using an oxidation-reduction reaction may include a base sheet 810 , a first electrode pattern 820A, and an absorption unit 830A.
  • the first electrode pattern 820A is disposed on the absorption unit 830A, and the exudate is formed on the first electrode pattern 820A. ), so that electrical activity can be rapidly generated.
  • the first electrode pattern 820A may be disposed to be recessed in the absorption unit 830A or disposed inside the absorption unit 830A.
  • the apparatus 800B for treating an affected area using an oxidation-reduction reaction may include a base sheet 810 , a first electrode pattern 820B, and an absorption unit 830B.
  • the absorption unit 830B is disposed between the first electrode patterns 820B and spaced apart from each other so as not to contact the first electrode patterns 820B.
  • the absorbent member AM absorbs the exudate EXD
  • the absorbent member AM expands to form the expanded region EP.
  • the first electrode material and the second electrode material are electrically connected to each other, so that an electrical stimulation can be provided to the affected area.
  • an apparatus for treating an affected area using an oxidation-reduction reaction 800C may include a base sheet 810 , an electrode unit 820C and an absorption unit 830C.
  • the electrode unit 820C may have a first electrode pattern 821C and a second electrode pattern 822C having different polarities, and are disposed to be spaced apart from each other.
  • the first electrode material EL1 may be mixed with the absorption member AM as shown in FIG. 15C .
  • the second electrode material EL2 may be mixed (not shown) in the absorption member AM. While the absorbent member AM absorbs the exudate EXD, the first electrode material EL1 or the second electrode material EL2 of the absorbent member electrically connects the electrode unit 820C to provide electrical stimulation to the affected area. can do.
  • the absorption unit 830C is disposed between the first electrode pattern 821C and the second electrode pattern 822C, so as not to contact the first electrode pattern 821C and the second electrode pattern 822C. can be placed.
  • the absorption unit 830C may expand and the first electrode pattern 821C and the second electrode pattern 822C may be electrically activated.
  • the apparatus 800D for treating an affected area using an oxidation-reduction reaction may include a base sheet 810 , an electrode unit 820D and an absorption unit 830D.
  • the electrode unit 820D may have a first electrode pattern 821D and a second electrode pattern 822D having different polarities, and are disposed to be spaced apart from each other.
  • the first electrode material EL1 and the second electrode material EL2 are mixed in the absorption member AM.
  • the first electrode material EL1 and the second electrode material EL2 in the form of particles may be electrically activated.
  • the absorption unit 830D may electrically activate the first electrode pattern 821D and the second electrode pattern 822D of the electrode unit 820D. That is, the absorbing unit 830D is electrically activated, and the electrode unit 820D is secondarily electrically activated to amplify the strength of the electrical stimulation and sustain the electrical stimulation.
  • the absorption unit 830D includes a first electrode material EL1 in the form of particles and a second electrode material EL2 in the form of particles, wherein the first electrode material EL1 in the form of particles is a second electrode
  • the second electrode material EL2 in the form of particles may be disposed adjacent to the pattern 822D and disposed adjacent to the first electrode pattern 821D.
  • the ratio of the first electrode material EL1 per unit volume in the absorption unit 830D increases as it approaches the second electrode pattern 822D, and the ratio of the second electrode material EL2 per unit volume in the absorption unit 830D may increase as it is adjacent to the first electrode pattern 821D.
  • a plurality of the first electrode material EL1 of the absorption unit 830D is disposed adjacent to the second electrode pattern 822D, so that electrical activity is amplified in the second electrode pattern 822D.
  • a plurality of second electrode materials EL2 of the absorption unit 830D are disposed adjacent to the first electrode pattern 821D, so that electrical activity in the first electrode pattern 821D may be amplified.
  • 16 is a diagram illustrating a method for treating an affected area using an oxidation-reduction reaction according to another embodiment of the present invention.
  • the recovery of the wound can be controlled according to the arrangement of the electrodes.
  • the first electrode pattern has a closed curve, and when the second electrode pattern is disposed inside the first electrode pattern, the recovery of the affected area proceeds toward the second electrode pattern. Thus, the wound heals towards one point.
  • the shape of the affected part of the subject is checked. Depending on the shape of the affected part, it may be considered whether the scar of the wound will be formed as a point or in a straight shape.
  • a device for treating the affected area using an oxidation-reduction reaction is selected and attached to the affected area.
  • a device having a second electrode pattern disposed inside the first electrode pattern of a closed curve as shown in FIG. 4C or 4D is attached to the affected part, and the second electrode pattern You can set the recovery direction so that the affected area is recovered.
  • the affected part is generated long in one direction, by arranging the second electrode pattern between the pair of first electrode patterns as shown in FIG. 4E, the affected part can be recovered toward the second electrode pattern.
  • the apparatus and method for treating a wounded area using an oxidation-reduction reaction may determine the direction of recovery of the affected area by adjusting the arrangement of the electrode unit and the electrode unit. Since the direction of the generated electric field affects the growth of fibroblasts, the direction of wound closure can be set by adjusting the arrangement of the electrode unit and the electrode unit.
  • 17 is a photograph comparing the treatment effect using the device for treating the affected area using the oxidation-reduction reaction according to the present invention.
  • the wound was treated by attaching the device of any one of Examples 1 to 8 to the four affected areas on the right side. When an electric field is applied to the affected part, it can be seen that the recovery rate of the wound is increased and it can be restored cleanly.
  • the present invention relates to a device for treating an affected area using reverse electrodialysis and oxidation-reduction reaction, and in particular, it can be used in an industrially used drug delivery and treatment device.

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Abstract

La présente invention concerne un dispositif de traitement de partie affectée utilisant une réaction d'oxydo-réduction. La présente invention comprend : une feuille de base; une unité d'électrode qui est fixée à la feuille de base et comprend des matériaux d'électrode ayant des polarités différentes; et une couche d'absorption qui est fixée à la feuille de base et active les matériaux d'électrode par un exsudat absorbé dans celle-ci de telle sorte que les matériaux d'électrode sont électriquement connectés l'un à l'autre.
PCT/KR2021/001592 2020-02-07 2021-02-05 Dispositif de traitement de partie affectée utilisant une réaction d'oxydo-réduction WO2021158083A1 (fr)

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KR20200015011 2020-02-07
KR10-2020-0015011 2020-02-07
KR10-2020-0135397 2020-10-19
KR1020200135397A KR102551684B1 (ko) 2020-02-07 2020-10-19 산화-환원 반응을 이용한 환부 치료 장치

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090270827A1 (en) * 2005-09-26 2009-10-29 Boerge Gundersen Dressing
US20180344533A1 (en) * 2017-06-01 2018-12-06 Absorbest Ab Wound dressing
US20190091071A1 (en) * 2013-06-10 2019-03-28 Ultramend, Inc. Nano-enhanced wound dressing
WO2019093944A1 (fr) * 2017-11-08 2019-05-16 Innovation Skåne Ab Nouveau biocapteur et système de pansement de plaie associé
US20200006783A1 (en) * 2017-03-03 2020-01-02 Ohio State Innovation Foundation Energy generation from fabric electrochemistry

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090270827A1 (en) * 2005-09-26 2009-10-29 Boerge Gundersen Dressing
US20190091071A1 (en) * 2013-06-10 2019-03-28 Ultramend, Inc. Nano-enhanced wound dressing
US20200006783A1 (en) * 2017-03-03 2020-01-02 Ohio State Innovation Foundation Energy generation from fabric electrochemistry
US20180344533A1 (en) * 2017-06-01 2018-12-06 Absorbest Ab Wound dressing
WO2019093944A1 (fr) * 2017-11-08 2019-05-16 Innovation Skåne Ab Nouveau biocapteur et système de pansement de plaie associé

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