WO2021149864A1 - Appareil de traitement du cancer à base de champ électrique - Google Patents

Appareil de traitement du cancer à base de champ électrique Download PDF

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Publication number
WO2021149864A1
WO2021149864A1 PCT/KR2020/002967 KR2020002967W WO2021149864A1 WO 2021149864 A1 WO2021149864 A1 WO 2021149864A1 KR 2020002967 W KR2020002967 W KR 2020002967W WO 2021149864 A1 WO2021149864 A1 WO 2021149864A1
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WIPO (PCT)
Prior art keywords
electric field
cancer treatment
patient
based cancer
treatment device
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PCT/KR2020/002967
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English (en)
Korean (ko)
Inventor
윤명근
오건
Original Assignee
고려대학교 산학협력단
주식회사 필드큐어
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 고려대학교 산학협력단, 주식회사 필드큐어 filed Critical 고려대학교 산학협력단
Publication of WO2021149864A1 publication Critical patent/WO2021149864A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Definitions

  • the present application relates to an electric field-based cancer treatment device, and more particularly, by generating an alternating current near the human body and the resulting magnetic flux change generates an induced electromotive force in the human body, the skin current per unit area is maintained below a certain level while maintaining the
  • the present invention relates to an electric field-based cancer treatment device that can maximize the electric field and deliver a high-intensity electric field to a tumor located deep inside the patient's body, thereby increasing the cancer treatment effect and lowering the skin current that causes side effects such as skin burns.
  • the first strength of electric field therapy is that it is known that the electric field has a great effect only on dividing cells, so it will intensively affect cancer cells that divide faster than normal cells, and the side effects are expected to be very minimal compared to existing treatments. The point is that it becomes (refer to Prior Document 2).
  • Prior Document 3 side effects of electric field treatment were significantly lower in 7 items out of a total of 9 comparison items of side effects between chemotherapy and electric field treatment, and in two items, chemotherapy and electric field treatment showed almost the same level of side effects.
  • the third strength is that when the electric field is applied extensively, including the treatment area, it is expected that it will have a therapeutic effect even on very fine tumors that are not visible on medical images such as CT.
  • an electric field is applied around the tumor, an electric field that cannot be ignored is transmitted not only to the tumor but also to the tumor area. Therefore, it is expected that the probability of cancer metastasis can also be dramatically reduced (refer to Prior Literature 5).
  • the current electric field cancer treatment method was approved by the US FDA for recurrent glioblastoma cancer in 2011 and for the first diagnosed glioblastoma in 2015. In Japan, it has been approved for treatment of patients with recurrent glioblastoma. In addition, the number of treated patients is increasing rapidly every year, showing a 50-fold increase from 152 in 2014 to 8813 in 2018 (refer to Prior Document 6).
  • the currently commercialized electric field cancer treatment system has been developed so that it can be treated only with an electric field with a weak intensity of about 1 to 3 V/cm, and in order to secure the maximum possible therapeutic effect with this weak electric field, the patient's sleep time is reduced. Except for, there is the inconvenience of having to receive treatment almost all day (18-24 hours/day)
  • the maximum limit current per unit area is 100 mA/cm 2 or less, but the recommended limit current per unit area recommended for electric field treatment is 30 mA/cm 2 or less (refer to Prior Document 7). Therefore, in order to maximize the therapeutic effect, a method is needed to increase the size of the electric field delivered to the body while maintaining the current flowing through the skin below the recommended limit current.
  • an embodiment of the present invention provides an electric field-based cancer treatment apparatus.
  • the electric field-based cancer treatment device is made in a coil shape to surround the affected part of the patient and includes a coiled conductor to which an alternating current is applied, and induction induced through a change in magnetic flux made by the coiled conductor to which the alternating current is applied. It is characterized in that the electromotive force is applied to the body of the patient.
  • the alternating current is characterized in that it has a frequency band in the range of 10 kHz to 300 kHz.
  • the coil-type conductor is characterized in that it has a geometric structure to surround the affected part of the patient by the internal space.
  • it characterized in that it further comprises one or more conductive media provided between the coil-type conductor and the patient.
  • the conductive medium is manufactured in a fixed form to fill a space between the first medium and the coiled conductor, and a first medium manufactured to be customized to the patient to be in contact with or adjacent to the skin of the patient. It is characterized in that it includes a second medium.
  • the conductive medium is characterized in that the electrical conductivity is 0.1 S/m or more.
  • the conductive medium is characterized in that the relative permeability (Relative permeability) is 2 or more.
  • the electric field-based cancer treatment device is a wearable device in which the conductive medium is attached to the body of the patient.
  • an alternating current is generated near the human body, and the resulting change in magnetic flux generates an induced electromotive force in the human body, so that the skin current per unit area is It is possible to maximize only the electric field inside the human body while maintaining it below a certain level. Therefore, compared to the prior art, by delivering an electric field of high intensity to a tumor located deep within the patient's body, the cancer treatment effect can be increased, and the skin current that causes side effects such as skin burns can be lowered.
  • 1 is a diagram illustrating a difference in treatment effect according to an electric field strength and an electric field application time during electric field treatment.
  • FIG. 2 is a schematic diagram of an electric field-based cancer treatment apparatus according to an embodiment of the present invention.
  • FIG. 3 is a diagram showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom after positioning the head and neck phantom in the solenoid in the electric field-based cancer treatment apparatus according to an embodiment of the present invention.
  • FIG. 4 is a diagram showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom by placing the conductive medium and the head and neck phantom together in the solenoid in the electric field-based cancer treatment device according to another embodiment of the present invention. .
  • FIG. 5 is a diagram illustrating the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom in the embodiment of the present invention shown in FIG. 4 .
  • FIG. 6 is a view showing the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 .
  • FIG. 7 is a diagram illustrating the results of calculating the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 .
  • FIG. 8 shows the induced electric field applied to the XY, XZ and YZ planes from the center of the head and neck phantom while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG. It is a diagram showing the distribution and size.
  • FIG. 9 shows the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG. 4 . It is a diagram showing one result.
  • FIG. 10 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the conductivity of the conductive medium in the embodiment of the present invention shown in FIG. 4 .
  • FIG. 11 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the relative permeability of the conductive medium in the embodiment of the present invention shown in FIG. 4 .
  • FIG. 12 is a diagram illustrating an example in which a conductive medium positioned inside a solenoid is separated into two regions according to another embodiment of the present invention.
  • FIG. 2 is a schematic diagram of an electric field-based cancer treatment apparatus according to an embodiment of the present invention.
  • the electric field-based cancer treatment apparatus 100 is formed in a coil shape to surround the affected part of the patient 10 and a coil-type conductor 110 to which an alternating current is applied. may be included, and an induced electromotive force induced through a magnetic flux change made by the coiled conductor 110 to which an alternating current is applied may be applied to the body of the patient 10 .
  • the alternating current applied to the coiled conductor 110 may have a frequency band in the range of 10 kHz to 300 kHz.
  • the coiled conductor 110 may have a geometric structure to surround the affected part of the patient 10 by the internal space, and a plurality of coiled conductors 110 may be connected in an array form.
  • the coil-type conductor 110 is exemplified as a cylindrical solenoid, but the present invention is not necessarily limited thereto, and the coil-type conductor 110 is a cuboid, a triangular prism, etc., the affected part of the patient 10 . It can be formed in various types of geometric structures that can apply the maximum induced electromotive force to the
  • the coil-type conducting wire 110 may be replaced with another type of electric field generating means (eg, an alternating current electric circuit, an electromagnet, etc.).
  • another type of electric field generating means eg, an alternating current electric circuit, an electromagnet, etc.
  • the present invention breaks away from the existing electric field cancer treatment method that uses at least one pair of electrodes to apply an electric field to the human body, so that an alternating current flows inside a conducting wire (eg, a coil-type conducting wire).
  • a conducting wire eg, a coil-type conducting wire.
  • the electric field-based cancer treatment apparatus 100 minimizes side effects that occur when an electrode attached to the skin is used by using the same principle, and at the same time adjusts the intensity of an alternating current applied to the body.
  • the electric field size can be adjusted.
  • one or more conductive media 120 provided between the coiled conductor 110 and the patient 10 may be further included, and the conductive media 120 is the patient 10 . It plays a role in increasing the strength of the electric field in the body.
  • the conductive medium 120 is a three-dimensional structure, and may refer not only to a medium composed of components similar to in vivo tissues, but also to a member having conductivity through which current can flow.
  • the conductive medium 120 may have an electrical conductivity of 0.1 S/m or more, and a relative permeability of 2 or more.
  • the electric field-based cancer treatment apparatus 100 described above with reference to FIG. 2 may be implemented as a wearable device in which the conductive medium 120 is attached to the patient's body 10 .
  • FIG. 3 is a view showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom by positioning the head and neck phantom in the solenoid in the electric field-based cancer treatment device according to an embodiment of the present invention, specifically 1 cm
  • the simulation results of the induced electric field (Field Intensity) and current density (Current Density) applied depending on the position when an alternating current of 1A is applied to a cylindrical solenoid with a diameter of 20 cm with 25 turns of the conductor is shown.
  • the head and neck phantom used is manufactured so that the physical size and electrical characteristics are similar to those of the human body.
  • FIG. 4 is an electric field-based cancer treatment device according to another embodiment of the present invention, in which a conductive medium and a head and neck phantom are placed together in a solenoid, and the magnitude and current density of the induced electric field applied to the inside of the head and neck phantom are calculated.
  • a cylindrical conductive medium and a head and neck phantom are placed together in the inner space of a cylindrical solenoid with a diameter of 100 cm in which a wire is wound 25 times per 1 cm, and an alternating current of 1A is applied to the cylindrical solenoid, the magnitude of the induced electric field applied according to the position
  • the simulation results of the current density are shown.
  • FIG. 5 is a diagram illustrating the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom in the embodiment of the present invention shown in FIG. 4 .
  • the inner space of the cylindrical solenoid is sufficiently large, and the greater the electric field is applied as the position of the head and neck phantom is farther from the inner center of the cylindrical solenoid. Due to these characteristics, in the embodiment of the present invention, the head and neck phantom or the affected part of the patient is preferably located at a point more than a preset distance from the center of the cylindrical solenoid.
  • the magnitude of the electric field applied to the center of the head and neck phantom is also about 4 V/cm, which increases the electric field by about 2 times or more compared to the method using the conventional electrode. know that it can be done.
  • the skin current density is about 6 mA/cm 2 or less, which is less than the recommended limit current of 30 mA/cm 2 , so that side effects due to the current are minimized.
  • FIG. 6 is a view showing the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom while changing the magnitude of the current in the embodiment of the present invention shown in FIG.
  • the distribution of the electric field applied to the inside of the head and neck phantom is shown when the magnitude of the alternating current is changed to 1A, 2A, and 3A.
  • FIG. 7 is a view showing the results of calculating the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 .
  • FIG. The results of calculating the average value of the magnitude of the electric field distributed inside the head and neck phantom and the average value of the current density applied to the surface are shown when the magnitude of the applied AC current is changed to 1A, 2A, 3A, and 4A.
  • FIG. 8 shows induction applied to the XY, XZ and YZ planes at the center of the head and neck phantom while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG.
  • This is a diagram showing the distribution and magnitude of the electric field. Specifically, when the magnitude of the alternating current is kept constant at 1A and the number of turns of the conductor per cm is changed to 25, 50, and 75, the electric field applied inside the head and neck phantom The distribution is shown.
  • FIG. 9 shows the size of the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while maintaining the same current magnitude and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG.
  • This is a diagram showing the result of calculating . Specifically, distribution inside the head and neck phantom when the size of the alternating current is kept constant at 1A and the number of turns per cm of the conductor is changed to 25, 50, 75, and 100 times. The results of calculating the average value of the magnitude of the electric field and the average value of the current density applied to the surface are shown.
  • FIG. 10 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the conductivity of the conductive medium in the embodiment of the present invention shown in FIG. It is a diagram showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the relative permeability of the conductive medium in the embodiment of the present invention.
  • the electric field synergistic effect in the head and neck phantom occurs when the electrical conductivity and the relative permeability of the conductive medium are respectively greater than a certain size. Specifically, when the electrical conductivity is 0.1 S/m or more, and the relative permeability is 2 or more, there is an electric field synergistic effect, and in particular, when the electrical conductivity is in the range of 6 S/m to 20 S/m, the largest electric field synergistic effect is shown. Able to know.
  • FIG. 12 is a diagram illustrating an example in which a conductive medium positioned inside a solenoid is separated into two regions according to another embodiment of the present invention.
  • the conductive medium 120 is a first medium (that is, the patient-customized medium (Customized Conducting Medium)) 121 manufactured to be in contact with or adjacent to the skin of the patient 10, and,
  • the second medium (ie, fixed shape of medium) 122 manufactured in a fixed shape to fill the space between the first medium 121 and the coiled conductor 110 may be implemented separately. there is.
  • the first medium 121 in direct contact with or adjacent to the patient 10 is customized for each patient, and the second medium 122 can be used in common for a plurality of patients, so that the electric field more efficiently It is possible to implement a cancer-based treatment device.
  • the electric field-based cancer treatment apparatus may be implemented in such a way that, for example, a patient enters the inside of a cylindrical electric field generator to receive treatment, and according to the above-described embodiment, a high electric field can be applied to the body. Unlike conventional methods based on electrodes, high-electric field treatment is possible for a short period of time, and thus a better electric field treatment effect can be achieved.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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Abstract

Selon un mode de réalisation, la présente invention concerne un appareil de traitement du cancer à base de champ électrique comprenant un fil d'attaque de type bobine qui prend la forme d'un type de bobine afin d'englober la partie touchée d'un patient, et auquel du courant alternatif est appliqué, et qui applique, à l'intérieur du corps du patient, une force électromotrice induite qui est induite à travers un changement de flux magnétique fabriqué à l'aide du fil d'attaque de type bobine auquel le courant alternatif est appliqué.
PCT/KR2020/002967 2020-01-21 2020-03-02 Appareil de traitement du cancer à base de champ électrique WO2021149864A1 (fr)

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KR10-2020-0007995 2020-01-21
KR1020200007995A KR20210094343A (ko) 2020-01-21 2020-01-21 전기장 기반 암치료 장치

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023049492A1 (fr) * 2021-09-27 2023-03-30 Ohio State Innovation Foundation Thérapie par champ électrique induit (ief) pour le traitement de cancers solides

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240024616A (ko) * 2022-08-17 2024-02-26 서울대학교산학협력단 자기 공명 영상 기반 교류 자기장 치료 시스템

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4426796B2 (ja) * 2003-08-26 2010-03-03 オリンパス株式会社 電力供給装置
US20110121834A1 (en) * 2008-08-18 2011-05-26 Hitachi Medical Corporation High-frequency coil and magnetic resonance imaging device
KR20110085708A (ko) * 2010-01-21 2011-07-27 한양대학교 산학협력단 전자기 유도를 이용한 의료 장치
KR20130088649A (ko) * 2012-01-31 2013-08-08 한경대학교 산학협력단 줄기세포 분화 또는 증식을 위한 자기장의 방향성 국소화 및 방향성 제어 방법 및 장치
KR20170134496A (ko) * 2015-04-03 2017-12-06 고쿠리츠다이가쿠호우진 도쿄다이가쿠 경두개 자기 자극 장치용 코일 장치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4426796B2 (ja) * 2003-08-26 2010-03-03 オリンパス株式会社 電力供給装置
US20110121834A1 (en) * 2008-08-18 2011-05-26 Hitachi Medical Corporation High-frequency coil and magnetic resonance imaging device
KR20110085708A (ko) * 2010-01-21 2011-07-27 한양대학교 산학협력단 전자기 유도를 이용한 의료 장치
KR20130088649A (ko) * 2012-01-31 2013-08-08 한경대학교 산학협력단 줄기세포 분화 또는 증식을 위한 자기장의 방향성 국소화 및 방향성 제어 방법 및 장치
KR20170134496A (ko) * 2015-04-03 2017-12-06 고쿠리츠다이가쿠호우진 도쿄다이가쿠 경두개 자기 자극 장치용 코일 장치

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023049492A1 (fr) * 2021-09-27 2023-03-30 Ohio State Innovation Foundation Thérapie par champ électrique induit (ief) pour le traitement de cancers solides

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