WO2021136825A1 - A dietary composition comprising an ingredient of interest - Google Patents

A dietary composition comprising an ingredient of interest Download PDF

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Publication number
WO2021136825A1
WO2021136825A1 PCT/EP2020/088068 EP2020088068W WO2021136825A1 WO 2021136825 A1 WO2021136825 A1 WO 2021136825A1 EP 2020088068 W EP2020088068 W EP 2020088068W WO 2021136825 A1 WO2021136825 A1 WO 2021136825A1
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WIPO (PCT)
Prior art keywords
dry mixture
amount
dietary composition
optionally
amount greater
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2020/088068
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French (fr)
Inventor
Caroline DONALDSON
Michael ALCORN
Johann TROTTER
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Devenish Research Development And Innovation Ltd
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Devenish Research Development And Innovation Ltd
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Filing date
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Publication of WO2021136825A1 publication Critical patent/WO2021136825A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/015—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/262—Cellulose; Derivatives thereof, e.g. ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/25—Agglomeration or granulation by extrusion or by pressing, e.g. through small holes, through sieves or between surfaces

Definitions

  • a dietary composition comprising an ingredient of interest.
  • the present invention relates to a dietary composition comprising an ingredient of interest, methods of preparing the dietary composition, a dietary feed comprising the dietary composition and use of cellulose in the preparation of the dietary composition.
  • the ingredients of interest are commonly in powder form.
  • a problem associated with such ingredients in powder form is particle size separation (i.e. a broad particle size distribution) resulting from inconsistent agglomeration of the powder ingredients. This can be problematic for a number of reasons. Firstly, smaller particles will separate down to the bottom of a mixture, which can lead to content uniformity issues. Secondly, fine particles can easily form a dust when pouring or transporting the powder ingredients, which ultimately results in loss of product and can potentially be hazardous.
  • a dietary composition comprising an ingredient of interest, the dietary composition comprising:
  • the dietary composition further comprises a source of calcium. Further optionally, the dietary composition further comprises a source of calcium in an amount greater than 1%(w/w) of the dry mixture.
  • the dietary composition comprises:
  • the cellulose is microcrystalline cellulose.
  • the dietary composition comprises:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the source of calcium is particulate calcium. Still further optionally, the source of calcium is milled calcium.
  • the source of calcium is limestone.
  • the source of calcium is particulate limestone. Still further optionally, the source of calcium is milled limestone.
  • the dietary composition comprises:
  • the dietary composition comprises:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the amount of microcrystalline cellulose and the amount of particulate limestone together form about 16%(w/w) of the dry mixture.
  • the amount of cellulose and the amount of the source of calcium together form about 15%(w/w) of the dry mixture.
  • the amount of microcrystalline cellulose and the amount of particulate limestone together form about 15%(w/w) of the dry mixture.
  • the amount of cellulose and the amount of the source of calcium together form about 14%(w/w) of the dry mixture.
  • the amount of microcrystalline cellulose and the amount of particulate limestone together form about 14%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 13%(w/w) of the dry mixture; and particulate limestone in an amount greater than 1%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 12%(w/w) of the dry mixture; and particulate limestone in an amount greater than 2%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 11%(w/w) of the dry mixture; and particulate limestone in an amount greater than 3%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 10%(w/w) of the dry mixture; and particulate limestone in an amount greater than 4%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 9%(w/w) of the dry mixture; and particulate limestone in an amount greater than 5%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 8%(w/w) of the dry mixture; and particulate limestone in an amount greater than 6%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 6%(w/w) of the dry mixture; and particulate limestone in an amount greater than 8%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 5%(w/w) of the dry mixture; and particulate limestone in an amount greater than 9%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 4%(w/w) of the dry mixture; and particulate limestone in an amount greater than 10%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 3%(w/w) of the dry mixture; and particulate limestone in an amount greater than 11%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 2%(w/w) of the dry mixture; and particulate limestone in an amount greater than 12%(w/w) of the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than
  • the dietary composition comprises microcrystalline cellulose in an amount less than 13%(w/w) of the dry mixture; and particulate limestone in an amount greater than 1%(w/w) of the dry mixture; and water in an amount greater than 22%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 12%(w/w) of the dry mixture; and particulate limestone in an amount greater than 2%(w/w) of the dry mixture; and water in an amount greater than 21%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than
  • the dietary composition comprises microcrystalline cellulose in an amount less than 10%(w/w) of the dry mixture; and particulate limestone in an amount greater than 4%(w/w) of the dry mixture; and water in an amount greater than 19%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 9%(w/w) of the dry mixture; and particulate limestone in an amount greater than 5%(w/w) of the dry mixture; and water in an amount greater than 18%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 8%(w/w) of the dry mixture; and particulate limestone in an amount greater than 6%(w/w) of the dry mixture; and water in an amount greater than 17%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture; and water in an amount greater than 16%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 6%(w/w) of the dry mixture; and particulate limestone in an amount greater than 8%(w/w) of the dry mixture; and water in an amount greater than 15%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 5%(w/w) of the dry mixture; and particulate limestone in an amount greater than 9%(w/w) of the dry mixture; and water in an amount greater than 14%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 4%(w/w) of the dry mixture; and particulate limestone in an amount greater than 10%(w/w) of the dry mixture; and water in an amount greater than 13%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 3%(w/w) of the dry mixture; and particulate limestone in an amount greater than 11%(w/w) of the dry mixture; and water in an amount greater than 12%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 2%(w/w) of the dry mixture; and particulate limestone in an amount greater than 12%(w/w) of the dry mixture; and water in an amount greater than 11%(w/w) relative to the dry mixture.
  • the dietary composition comprises microcrystalline cellulose in an amount less than 1 %(w/w) of the dry mixture; and particulate limestone in an amount greater than 13%(w/w) of the dry mixture; and water in an amount greater than 10%(w/w) relative to the dry mixture.
  • composition further comprises starch.
  • composition further comprises starch in an amount less than 1 %(w/w) of the dry mixture.
  • the dietary composition comprises:
  • the dietary composition comprises:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the dietary composition comprises:
  • the dietary composition comprises: (c) a dry mixture comprising:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the starch is a modified starch.
  • the starch is a cooked starch.
  • the starch is a dried starch.
  • the starch is a dried cooked starch.
  • the starch is a pregelatinised starch.
  • the dietary composition comprises:
  • the dietary composition comprises: (a) a dry mixture comprising:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the dietary composition comprises:
  • microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture
  • the dietary composition comprises:
  • microcrystalline cellulose in an amount of 7%(w/w) of the dry mixture
  • the dietary composition is a granular composition. Further optionally, the dietary composition is a granular composition, wherein the granules have a diameter of less than 5mm. Further optionally, the dietary composition is a granular composition, wherein the granules have a diameter of less than 4mm.
  • the dietary composition is a granular composition, wherein the granules have a diameter of less than 3mm.
  • the dietary composition is a granular composition, wherein the granules have a diameter of less than 2mm.
  • the dietary composition is a granular composition, wherein the granules have a diameter of less than 1 mm.
  • the dietary composition is a granular composition, wherein the granules are substantially spherical in form.
  • the dietary composition is a granular composition, wherein the granules have a substantially uniform particle size distribution.
  • a method of preparing the dietary composition according to the first aspect of the present invention comprising the steps of:
  • the method comprises the step of admixing a source of calcium.
  • the method comprises the step of admixing a source of calcium in an amount greater than 1%(w/w) of the dry mixture.
  • the method comprises:
  • the cellulose is microcrystalline cellulose.
  • the method comprises:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the source of calcium is particulate calcium. Still further optionally, the source of calcium is milled calcium.
  • the source of calcium is limestone.
  • the source of calcium is particulate limestone. Still further optionally, the source of calcium is milled limestone.
  • the method comprises:
  • the method comprises:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the amount of cellulose and the amount of the source of calcium together form about 16%(w/w) of the dry mixture.
  • the amount of microcrystalline cellulose and the amount of particulate limestone together form about 16%(w/w) of the dry mixture.
  • the amount of cellulose and the amount of the source of calcium together form about 15%(w/w) of the dry mixture.
  • the amount of microcrystalline cellulose and the amount of particulate limestone together form about 15%(w/w) of the dry mixture.
  • the amount of cellulose and the amount of the source of calcium together form about 14%(w/w) of the dry mixture.
  • the amount of microcrystalline cellulose and the amount of particulate limestone together form about 14%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 13%(w/w) of the dry mixture; and particulate limestone in an amount greater than 1%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 12%(w/w) of the dry mixture; and particulate limestone in an amount greater than 2%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than
  • the method comprises admixing microcrystalline cellulose in an amount less than 10%(w/w) of the dry mixture; and particulate limestone in an amount greater than 4%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 9%(w/w) of the dry mixture; and particulate limestone in an amount greater than 5%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 8%(w/w) of the dry mixture; and particulate limestone in an amount greater than 6%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 6%(w/w) of the dry mixture; and particulate limestone in an amount greater than 8%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 5%(w/w) of the dry mixture; and particulate limestone in an amount greater than 9%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 4%(w/w) of the dry mixture; and particulate limestone in an amount greater than 10%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 3%(w/w) of the dry mixture; and particulate limestone in an amount greater than 11%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 2%(w/w) of the dry mixture; and particulate limestone in an amount greater than 12%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 1 %(w/w) of the dry mixture; and particulate limestone in an amount greater than 13%(w/w) of the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 13%(w/w) of the dry mixture; and particulate limestone in an amount greater than 1%(w/w) of the dry mixture; and adding water in an amount greater than 22%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 12%(w/w) of the dry mixture; and particulate limestone in an amount greater than 2%(w/w) of the dry mixture; and adding water in an amount greater than 21%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 11%(w/w) of the dry mixture; and particulate limestone in an amount greater than 3%(w/w) of the dry mixture; and adding water in an amount greater than 20%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 10%(w/w) of the dry mixture; and particulate limestone in an amount greater than 4%(w/w) of the dry mixture; and adding water in an amount greater than 19%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 9%(w/w) of the dry mixture; and particulate limestone in an amount greater than 5%(w/w) of the dry mixture; and adding water in an amount greater than 18%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 8%(w/w) of the dry mixture; and particulate limestone in an amount greater than 6%(w/w) of the dry mixture; and adding water in an amount greater than 17%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture; and adding water in an amount greater than 16%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 6%(w/w) of the dry mixture; and particulate limestone in an amount greater than 8%(w/w) of the dry mixture; and adding water in an amount greater than 15%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 5%(w/w) of the dry mixture; and particulate limestone in an amount greater than 9%(w/w) of the dry mixture; and adding water in an amount greater than 14%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 4%(w/w) of the dry mixture; and particulate limestone in an amount greater than 10%(w/w) of the dry mixture; and adding water in an amount greater than 13%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 3%(w/w) of the dry mixture; and particulate limestone in an amount greater than 11%(w/w) of the dry mixture; and adding water in an amount greater than 12%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 2%(w/w) of the dry mixture; and particulate limestone in an amount greater than 12%(w/w) of the dry mixture; and adding water in an amount greater than 11%(w/w) relative to the dry mixture.
  • the method comprises admixing microcrystalline cellulose in an amount less than 1 %(w/w) of the dry mixture; and particulate limestone in an amount greater than 13%(w/w) of the dry mixture; and adding water in an amount greater than 10%(w/w) relative to the dry mixture.
  • the method further comprises admixing starch.
  • the method further comprises admixing starch in an amount less than 1%(w/w) of the dry mixture.
  • the method comprises:
  • the method comprises:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the method comprises: (a) admixing:
  • the method comprises:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the starch is a modified starch.
  • the starch is a cooked starch.
  • the starch is a dried starch.
  • the starch is a dried cooked starch.
  • the starch is a pregelatinised starch.
  • the method comprises:
  • the method comprises:
  • microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture
  • the method comprises:
  • microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture
  • the method comprises:
  • microcrystalline cellulose in an amount of 7%(w/w) of the dry mixture
  • the method comprises the additional step of extruding the dietary composition.
  • the method comprises the additional step of mass extruding the dietary composition.
  • the method comprises the additional step of wet mass extruding the dietary composition.
  • the method comprises the additional step of wet mass extruding the dietary composition using a screw extruder.
  • the method comprises the additional step of wet mass extruding the dietary composition using a twin screw extruder.
  • the method comprises the additional step of pelletising the dietary composition.
  • the method comprises the additional step of spheronising the dietary composition.
  • the method comprises the additional step of spheronising the dietary composition using a spheroniser.
  • the method comprises the additional step of spheronising the dietary composition for at least 1 minute.
  • the method comprises the additional step of spheronising the dietary composition for at least 2 minutes.
  • the method comprises the additional step of spheronising the dietary composition for at least 3 minutes.
  • the method comprises the additional step of spheronising the dietary composition for at least 4 minutes.
  • the method comprises the additional step of spheronising the dietary composition for at least 5 minutes.
  • Pelletisation or spheronisation can be achieved by various techniques.
  • the type of equipment that can be used in the present invention is the one that produces pellets by extrusion and/or spheronisation.
  • a spheroniser incorporates a vertical cylindrical chamber containing a rotating plate at the base, a lid at the top and a port for discharge of the pellets on the side. Both the speed of rotation and the surface of the rotating plate can be changed according to the user's needs.
  • This plate's surface can be flat and smooth, rough, or engraved with a defined geometric pattern (cross- hatch or radial-hatch design), therefore increasing the attrition and friction between the plate and the material being processed.
  • the present invention so relates to the preparation of spheroids from rods produced by extrusion of materials.
  • These extrudates can be produced from masses, preferably wet masses.
  • These extrudates are submitted to a rotational movement (toroidal) where they are shaped into spheroids.
  • the spheronisation modifies the size and shape of extrudates namely the ones produced in an extruder fitted with a cylindrical, single or multiple die.
  • the physical properties of these rods are modified both in their shape (become spherical) and mechanical structure (the mechanical strength and the density increase).
  • the method comprises the additional step of dehydrating the dietary composition. Further optionally, the method comprises the additional step of dehydrating the extruded dietary composition.
  • the method comprises the additional step of dehydrating the extruded, spheronised dietary composition.
  • the dehydration step is conducted at a temperature of greater than 10°C, optionally greater than 12°C, optionally greater than 14°C, optionally greater than 16°C, optionally greater than 18°C, optionally greater than 20°C, optionally greater than 22°C, optionally greater than 24°C, optionally greater than 26°C, optionally greater than 28°C, optionally greater than 30°C, optionally greater than 32°C, optionally greater than 34°C, optionally greater than 36°C, optionally greater than 38°C, optionally greater than 40°C, optionally greater than 42°C.
  • a dietary feed comprising the dietary composition according to the first aspect of the present invention, or the dietary composition obtained by the method according to the further aspect of the present invention.
  • cellulose in an amount less than 15%(w/w) for preparing a dietary composition comprising an ingredient of interest.
  • cellulose in an amount less than 15%(w/w) for preparing a granular dietary composition comprising an ingredient of interest.
  • cellulose in an amount less than 15%(w/w) and a source of calcium in an amount greater than 1%(w/w) of the dry mixture for preparing a dietary composition comprising an ingredient of interest.
  • cellulose in an amount less than 15%(w/w) and a source of calcium in an amount greater than 1%(w/w) of the dry mixture for preparing a granular dietary composition comprising an ingredient of interest.
  • cellulose in an amount less than 15%(w/w) and a source of calcium in an amount greater than 1%(w/w) of the dry mixture for preparing a dietary composition according to a first aspect of the present invention.
  • the cellulose is microcrystalline cellulose.
  • the source of calcium is particulate calcium. Still further optionally, the source of calcium is milled calcium.
  • the source of calcium is limestone. Further optionally, the source of calcium is particulate limestone. Still further optionally, the source of calcium is milled limestone.
  • Figure 1 illustrates the particle size distribution of the dry powder ingredient of interest
  • Figure 2A illustrates the particle size distribution of the dietary composition
  • Figure 2B compares the particle size distribution of the dry powder ingredient of interest and the dietary composition
  • Figure 3 illustrates the effect on thermal properties of the dry powder ingredient of interest
  • Figure 4 illustrates scanning electron microscopy analysis of the dietary composition.
  • Starch 1500 ® partially pregelatinised maize starch was commercially obtained from Colorcon.
  • Microcrystalline cellulose 102 was commercially obtained from FMC Corporation.
  • Limestone flour was obtained from Kilwaughter Chemical Company.
  • a dry powder ingredient of interest was prepared in-house at Devenish Research Development and Innovation Limited.
  • dry powder ingredient of interest 85.45% w/w
  • microcrystalline cellulose 6.81% w/w
  • limestone flour 6.81% w/w
  • pregelatinised starch 0.91% w/w
  • the particle size distribution of the dry powder ingredient of interest was determined using sieve analysis. In short, a series of sieves ranging in sizes from 2000 pm to 45 pm was used, and a sample of the dry powder ingredient of interest was placed on top of the series of sieves and the series was then placed onto a shaking system in order to separate the dry powder ingredient of interest according to particle size.
  • a dietary composition was prepared according to the general methods described herein.
  • the particle size distribution of each of the dry powder ingredient of interest and the dietary composition was determined using sieve analysis as described in Example 1 .
  • Figure 2A illustrates the particle size distribution of the dietary composition.
  • Figure 2B illustrates the dietary composition has a significantly reduced range of particle size, and the greatest proportion lies in the range of around 0.5 mm to 1 mm.
  • the thermal properties of the dry powder ingredient of interest were assessed to determine the effects a sterilisation process (usually of a temperature of about 80°C for about 6 minutes). As water is added in during the method of preparing the dietary composition, an initial heat and hold step was added in order to dry out the samples to allow for a more direct comparison.
  • the thermal degradation temperature is taken as the temperature at which a 5% decrease in weight occurs.
  • the thermal degradation temperature for the dry powder ingredient of interest was 227°C and the thermal degradation temperature for the dietary composition was 226°C, so there was statistically no difference between the thermal degradation temperatures, indicating that the method of preparing the dietary composition does not affect the thermal properties of the dry powder ingredient of interest.
  • Imaging of the dietary composition A sample of the dietary composition was analysed using scanning electron microscopy. The granules of the dietary composition were seen to be relatively spherical, which should indicate good flowability.

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Abstract

The present invention relates to a dietary composition comprising an ingredient of interest, methods of preparing the dietary composition, a dietary feed comprising the dietary composition and use of cellulose in the preparation of the dietary composition. In embodiments, the dietary composition comprises a dry mixture comprising microcrystalline cellulose; particulate limestone; pregelatinised starch; and the ingredient of interest; and water.

Description

Title of the Invention
A dietary composition comprising an ingredient of interest.
Field of the Invention
The present invention relates to a dietary composition comprising an ingredient of interest, methods of preparing the dietary composition, a dietary feed comprising the dietary composition and use of cellulose in the preparation of the dietary composition.
Background to the Invention
Dietary feeds that are commercially manufactured for animals such as poultry and swine frequently contain an ingredient of interest that needs to be incorporated into the dietary feed for consumption. The ingredients of interest are commonly in powder form.
A problem associated with such ingredients in powder form is particle size separation (i.e. a broad particle size distribution) resulting from inconsistent agglomeration of the powder ingredients. This can be problematic for a number of reasons. Firstly, smaller particles will separate down to the bottom of a mixture, which can lead to content uniformity issues. Secondly, fine particles can easily form a dust when pouring or transporting the powder ingredients, which ultimately results in loss of product and can potentially be hazardous.
There is a need to provide a dietary composition comprising an ingredient of interest that can avoid this particle size separation, improve flow characteristics, and reduce the formation of hazardous dust and so loss of product.
Less wastage could lead to economical, environmental and sustainability benefits.
Summary of the Invention
According to a first aspect of the present invention, there is provided a dietary composition comprising an ingredient of interest, the dietary composition comprising:
(a) a dry mixture comprising:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture; and
(ii) the ingredient of interest; and
(b) water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the dietary composition further comprises a source of calcium. Further optionally, the dietary composition further comprises a source of calcium in an amount greater than 1%(w/w) of the dry mixture.
Optionally, the dietary composition comprises:
(a) a dry mixture comprising:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) a source of calcium in an amount greater than 1%(w/w) of the dry mixture; and
(iii) the ingredient of interest; and
(b) water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the cellulose is microcrystalline cellulose.
Optionally, the dietary composition comprises:
(a) a dry mixture comprising:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) a source of calcium in an amount greater than 1 %(w/w) of the dry mixture; and
(iii) the ingredient of interest; and
(b) water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the source of calcium is particulate calcium. Still further optionally, the source of calcium is milled calcium.
Optionally, the source of calcium is limestone.
Further optionally, the source of calcium is particulate limestone. Still further optionally, the source of calcium is milled limestone.
Optionally, the dietary composition comprises:
(c) a dry mixture comprising:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1%(w/w) of the dry mixture; and
(iii) the ingredient of interest; and
(d) water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the dietary composition comprises:
(c) a dry mixture comprising:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1%(w/w) of the dry mixture; and
(iii) the ingredient of interest; and
(d) water in an amount greater than 10%(w/w) relative to the dry mixture. Optionally, the amount of cellulose and the amount of the source of calcium together form about 16%(w/w) of the dry mixture.
Further optionally, the amount of microcrystalline cellulose and the amount of particulate limestone together form about 16%(w/w) of the dry mixture.
Optionally, the amount of cellulose and the amount of the source of calcium together form about 15%(w/w) of the dry mixture.
Further optionally, the amount of microcrystalline cellulose and the amount of particulate limestone together form about 15%(w/w) of the dry mixture.
Optionally, the amount of cellulose and the amount of the source of calcium together form about 14%(w/w) of the dry mixture.
Further optionally, the amount of microcrystalline cellulose and the amount of particulate limestone together form about 14%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 13%(w/w) of the dry mixture; and particulate limestone in an amount greater than 1%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 12%(w/w) of the dry mixture; and particulate limestone in an amount greater than 2%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 11%(w/w) of the dry mixture; and particulate limestone in an amount greater than 3%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 10%(w/w) of the dry mixture; and particulate limestone in an amount greater than 4%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 9%(w/w) of the dry mixture; and particulate limestone in an amount greater than 5%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 8%(w/w) of the dry mixture; and particulate limestone in an amount greater than 6%(w/w) of the dry mixture. Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 6%(w/w) of the dry mixture; and particulate limestone in an amount greater than 8%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 5%(w/w) of the dry mixture; and particulate limestone in an amount greater than 9%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 4%(w/w) of the dry mixture; and particulate limestone in an amount greater than 10%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 3%(w/w) of the dry mixture; and particulate limestone in an amount greater than 11%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 2%(w/w) of the dry mixture; and particulate limestone in an amount greater than 12%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than
I %(w/w) of the dry mixture; and particulate limestone in an amount greater than 13%(w/w) of the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 13%(w/w) of the dry mixture; and particulate limestone in an amount greater than 1%(w/w) of the dry mixture; and water in an amount greater than 22%(w/w) relative to the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 12%(w/w) of the dry mixture; and particulate limestone in an amount greater than 2%(w/w) of the dry mixture; and water in an amount greater than 21%(w/w) relative to the dry mixture..
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than
I I %(w/w) of the dry mixture; and particulate limestone in an amount greater than 3%(w/w) of the dry mixture; and water in an amount greater than 20%(w/w) relative to the dry mixture.. Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 10%(w/w) of the dry mixture; and particulate limestone in an amount greater than 4%(w/w) of the dry mixture; and water in an amount greater than 19%(w/w) relative to the dry mixture..
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 9%(w/w) of the dry mixture; and particulate limestone in an amount greater than 5%(w/w) of the dry mixture; and water in an amount greater than 18%(w/w) relative to the dry mixture..
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 8%(w/w) of the dry mixture; and particulate limestone in an amount greater than 6%(w/w) of the dry mixture; and water in an amount greater than 17%(w/w) relative to the dry mixture..
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture; and water in an amount greater than 16%(w/w) relative to the dry mixture..
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 6%(w/w) of the dry mixture; and particulate limestone in an amount greater than 8%(w/w) of the dry mixture; and water in an amount greater than 15%(w/w) relative to the dry mixture..
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 5%(w/w) of the dry mixture; and particulate limestone in an amount greater than 9%(w/w) of the dry mixture; and water in an amount greater than 14%(w/w) relative to the dry mixture..
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 4%(w/w) of the dry mixture; and particulate limestone in an amount greater than 10%(w/w) of the dry mixture; and water in an amount greater than 13%(w/w) relative to the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 3%(w/w) of the dry mixture; and particulate limestone in an amount greater than 11%(w/w) of the dry mixture; and water in an amount greater than 12%(w/w) relative to the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 2%(w/w) of the dry mixture; and particulate limestone in an amount greater than 12%(w/w) of the dry mixture; and water in an amount greater than 11%(w/w) relative to the dry mixture.
Optionally, the dietary composition comprises microcrystalline cellulose in an amount less than 1 %(w/w) of the dry mixture; and particulate limestone in an amount greater than 13%(w/w) of the dry mixture; and water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the composition further comprises starch. Further optionally, the composition further comprises starch in an amount less than 1 %(w/w) of the dry mixture.
Optionally, the dietary composition comprises:
(e) a dry mixture comprising:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch; and
(iv) the ingredient of interest; and
(f) water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the dietary composition comprises:
(a) a dry mixture comprising:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the dietary composition comprises:
(g) a dry mixture comprising:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch; and
(iv) the ingredient of interest; and
(h) water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the dietary composition comprises: (c) a dry mixture comprising:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and (d) water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the starch is a modified starch.
Optionally, the starch is a cooked starch.
Optionally or additionally, the starch is a dried starch. Optionally, the starch is a dried cooked starch.
Optionally, the starch is a pregelatinised starch.
Preferably, the dietary composition comprises:
(a) a dry mixture comprising:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) a source of calcium in an amount greater than 1%(w/w) of the dry mixture;
(iii) starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) water in an amount greater than 10%(w/w) relative to the dry mixture.
Further preferably, the dietary composition comprises: (a) a dry mixture comprising:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) pregelatinised starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and (b) water in an amount greater than 10%(w/w) relative to the dry mixture.
Still further preferably, the dietary composition comprises:
(a) a dry mixture comprising:
(i) microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 7%(w/w) of the dry mixture;
(iii) pregelatinised starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) water in an amount greater than 20%(w/w) relative to the dry mixture.
Still further preferably, the dietary composition comprises:
(a) a dry mixture comprising:
(i) microcrystalline cellulose in an amount of 7%(w/w) of the dry mixture;
(ii) particulate limestone in an amount of 7%(w/w) of the dry mixture;
(iii) pregelatinised starch in an amount of 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) water in an amount of 20%(w/w) relative to the dry mixture.
Optionally, the dietary composition is a granular composition. Further optionally, the dietary composition is a granular composition, wherein the granules have a diameter of less than 5mm. Further optionally, the dietary composition is a granular composition, wherein the granules have a diameter of less than 4mm.
Further optionally, the dietary composition is a granular composition, wherein the granules have a diameter of less than 3mm.
Further optionally, the dietary composition is a granular composition, wherein the granules have a diameter of less than 2mm.
Further optionally, the dietary composition is a granular composition, wherein the granules have a diameter of less than 1 mm.
Optionally or additionally, the dietary composition is a granular composition, wherein the granules are substantially spherical in form.
Optionally or additionally, the dietary composition is a granular composition, wherein the granules have a substantially uniform particle size distribution.
According to a further aspect of the present invention, there is provided a method of preparing the dietary composition according to the first aspect of the present invention, the method comprising the steps of:
(a) admixing:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture; and
(ii) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the method comprises the step of admixing a source of calcium.
Further optionally, the method comprises the step of admixing a source of calcium in an amount greater than 1%(w/w) of the dry mixture.
Optionally, the method comprises:
(a) admixing:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) a source of calcium in an amount greater than 1%(w/w) of the dry mixture; and
(iii) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the cellulose is microcrystalline cellulose. Optionally, the method comprises:
(a) admixing :
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) a source of calcium in an amount greater than 1%(w/w) of the dry mixture; and
(iii) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the source of calcium is particulate calcium. Still further optionally, the source of calcium is milled calcium.
Optionally, the source of calcium is limestone.
Further optionally, the source of calcium is particulate limestone. Still further optionally, the source of calcium is milled limestone.
Optionally, the method comprises:
(a) admixing:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1%(w/w) of the dry mixture; and
(iii) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the method comprises:
(a) admixing:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1%(w/w) of the dry mixture; and
(iii) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the amount of cellulose and the amount of the source of calcium together form about 16%(w/w) of the dry mixture.
Further optionally, the amount of microcrystalline cellulose and the amount of particulate limestone together form about 16%(w/w) of the dry mixture.
Optionally, the amount of cellulose and the amount of the source of calcium together form about 15%(w/w) of the dry mixture.
Further optionally, the amount of microcrystalline cellulose and the amount of particulate limestone together form about 15%(w/w) of the dry mixture. Optionally, the amount of cellulose and the amount of the source of calcium together form about 14%(w/w) of the dry mixture.
Further optionally, the amount of microcrystalline cellulose and the amount of particulate limestone together form about 14%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 13%(w/w) of the dry mixture; and particulate limestone in an amount greater than 1%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 12%(w/w) of the dry mixture; and particulate limestone in an amount greater than 2%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than
11 %(w/w) of the dry mixture; and particulate limestone in an amount greater than 3%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 10%(w/w) of the dry mixture; and particulate limestone in an amount greater than 4%(w/w) of the dry mixture.
Optionally the method comprises admixing microcrystalline cellulose in an amount less than 9%(w/w) of the dry mixture; and particulate limestone in an amount greater than 5%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 8%(w/w) of the dry mixture; and particulate limestone in an amount greater than 6%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 6%(w/w) of the dry mixture; and particulate limestone in an amount greater than 8%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 5%(w/w) of the dry mixture; and particulate limestone in an amount greater than 9%(w/w) of the dry mixture. Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 4%(w/w) of the dry mixture; and particulate limestone in an amount greater than 10%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 3%(w/w) of the dry mixture; and particulate limestone in an amount greater than 11%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 2%(w/w) of the dry mixture; and particulate limestone in an amount greater than 12%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 1 %(w/w) of the dry mixture; and particulate limestone in an amount greater than 13%(w/w) of the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 13%(w/w) of the dry mixture; and particulate limestone in an amount greater than 1%(w/w) of the dry mixture; and adding water in an amount greater than 22%(w/w) relative to the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 12%(w/w) of the dry mixture; and particulate limestone in an amount greater than 2%(w/w) of the dry mixture; and adding water in an amount greater than 21%(w/w) relative to the dry mixture..
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 11%(w/w) of the dry mixture; and particulate limestone in an amount greater than 3%(w/w) of the dry mixture; and adding water in an amount greater than 20%(w/w) relative to the dry mixture..
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 10%(w/w) of the dry mixture; and particulate limestone in an amount greater than 4%(w/w) of the dry mixture; and adding water in an amount greater than 19%(w/w) relative to the dry mixture..
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 9%(w/w) of the dry mixture; and particulate limestone in an amount greater than 5%(w/w) of the dry mixture; and adding water in an amount greater than 18%(w/w) relative to the dry mixture..
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 8%(w/w) of the dry mixture; and particulate limestone in an amount greater than 6%(w/w) of the dry mixture; and adding water in an amount greater than 17%(w/w) relative to the dry mixture.. Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture; and adding water in an amount greater than 16%(w/w) relative to the dry mixture..
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 6%(w/w) of the dry mixture; and particulate limestone in an amount greater than 8%(w/w) of the dry mixture; and adding water in an amount greater than 15%(w/w) relative to the dry mixture..
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 5%(w/w) of the dry mixture; and particulate limestone in an amount greater than 9%(w/w) of the dry mixture; and adding water in an amount greater than 14%(w/w) relative to the dry mixture..
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 4%(w/w) of the dry mixture; and particulate limestone in an amount greater than 10%(w/w) of the dry mixture; and adding water in an amount greater than 13%(w/w) relative to the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 3%(w/w) of the dry mixture; and particulate limestone in an amount greater than 11%(w/w) of the dry mixture; and adding water in an amount greater than 12%(w/w) relative to the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 2%(w/w) of the dry mixture; and particulate limestone in an amount greater than 12%(w/w) of the dry mixture; and adding water in an amount greater than 11%(w/w) relative to the dry mixture.
Optionally, the method comprises admixing microcrystalline cellulose in an amount less than 1 %(w/w) of the dry mixture; and particulate limestone in an amount greater than 13%(w/w) of the dry mixture; and adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the method further comprises admixing starch.
Further optionally, the method further comprises admixing starch in an amount less than 1%(w/w) of the dry mixture.
Optionally, the method comprises:
(a) admixing:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch; and
(iv) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture. Optionally, the method comprises:
(a) admixing:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the method comprises: (a) admixing:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch; and
(iv) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Optionally, the method comprises:
(a) admixing:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture. Optionally, the starch is a modified starch.
Optionally, the starch is a cooked starch.
Optionally or additionally, the starch is a dried starch.
Optionally, the starch is a dried cooked starch.
Optionally, the starch is a pregelatinised starch.
Preferably, the method comprises:
(a) admixing:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) a source of calcium in an amount greater than 1 %(w/w) of the dry mixture;
(iii) starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture. Further preferably, the method comprises:
(a) admixing:
(i) microcrystalline cellulose in an amount less than 15%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 1 %(w/w) of the dry mixture;
(iii) pregelatinised starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
Still further preferably, the method comprises:
(a) admixing:
(i) microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture;
(ii) particulate limestone in an amount greater than 7%(w/w) of the dry mixture;
(iii) pregelatinised starch in an amount less than 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) adding water in an amount greater than 20%(w/w) relative to the dry mixture.
Still further preferably, the method comprises:
(a) admixing:
(i) microcrystalline cellulose in an amount of 7%(w/w) of the dry mixture;
(ii) particulate limestone in an amount of 7%(w/w) of the dry mixture;
(iii) pregelatinised starch in an amount of 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) adding water in an amount of 20%(w/w) relative to the dry mixture.
Optionally, the method comprises the additional step of extruding the dietary composition.
Further optionally, the method comprises the additional step of mass extruding the dietary composition.
Still further optionally, the method comprises the additional step of wet mass extruding the dietary composition.
Still further optionally, the method comprises the additional step of wet mass extruding the dietary composition using a screw extruder.
Still further optionally, the method comprises the additional step of wet mass extruding the dietary composition using a twin screw extruder. Optionally or additionally, the method comprises the additional step of pelletising the dietary composition. Further optionally or additionally, the method comprises the additional step of spheronising the dietary composition.
Still further optionally or additionally, the method comprises the additional step of spheronising the dietary composition using a spheroniser.
Optionally or additionally, the method comprises the additional step of spheronising the dietary composition for at least 1 minute.
Further optionally or additionally, the method comprises the additional step of spheronising the dietary composition for at least 2 minutes.
Still further optionally or additionally, the method comprises the additional step of spheronising the dietary composition for at least 3 minutes.
Still further optionally or additionally, the method comprises the additional step of spheronising the dietary composition for at least 4 minutes.
Still further optionally or additionally, the method comprises the additional step of spheronising the dietary composition for at least 5 minutes.
Pelletisation or spheronisation can be achieved by various techniques. The type of equipment that can be used in the present invention is the one that produces pellets by extrusion and/or spheronisation. A spheroniser incorporates a vertical cylindrical chamber containing a rotating plate at the base, a lid at the top and a port for discharge of the pellets on the side. Both the speed of rotation and the surface of the rotating plate can be changed according to the user's needs. This plate's surface can be flat and smooth, rough, or engraved with a defined geometric pattern (cross- hatch or radial-hatch design), therefore increasing the attrition and friction between the plate and the material being processed.
The present invention so relates to the preparation of spheroids from rods produced by extrusion of materials. These extrudates can be produced from masses, preferably wet masses. These extrudates are submitted to a rotational movement (toroidal) where they are shaped into spheroids. Briefly, the spheronisation modifies the size and shape of extrudates namely the ones produced in an extruder fitted with a cylindrical, single or multiple die. The physical properties of these rods are modified both in their shape (become spherical) and mechanical structure (the mechanical strength and the density increase).
Optionally, the method comprises the additional step of dehydrating the dietary composition. Further optionally, the method comprises the additional step of dehydrating the extruded dietary composition.
Further optionally or additionally, the method comprises the additional step of dehydrating the extruded, spheronised dietary composition.
Optionally, the dehydration step is conducted at a temperature of greater than 10°C, optionally greater than 12°C, optionally greater than 14°C, optionally greater than 16°C, optionally greater than 18°C, optionally greater than 20°C, optionally greater than 22°C, optionally greater than 24°C, optionally greater than 26°C, optionally greater than 28°C, optionally greater than 30°C, optionally greater than 32°C, optionally greater than 34°C, optionally greater than 36°C, optionally greater than 38°C, optionally greater than 40°C, optionally greater than 42°C.
According to a further aspect of the present invention, there is provided a dietary feed comprising the dietary composition according to the first aspect of the present invention, or the dietary composition obtained by the method according to the further aspect of the present invention.
According to a further aspect of the present invention, there is provided use of cellulose in an amount less than 15%(w/w) for preparing a dietary composition comprising an ingredient of interest.
Optionally, there is provided use of cellulose in an amount less than 15%(w/w) for preparing a granular dietary composition comprising an ingredient of interest.
Optionally, there is provided use of cellulose in an amount less than 15%(w/w) and a source of calcium in an amount greater than 1%(w/w) of the dry mixture for preparing a dietary composition comprising an ingredient of interest.
Optionally, there is provided use of cellulose in an amount less than 15%(w/w) and a source of calcium in an amount greater than 1%(w/w) of the dry mixture for preparing a granular dietary composition comprising an ingredient of interest.
Optionally, there is provided use of cellulose in an amount less than 15%(w/w) and a source of calcium in an amount greater than 1%(w/w) of the dry mixture for preparing a dietary composition according to a first aspect of the present invention.
Optionally, the cellulose is microcrystalline cellulose.
Optionally, the source of calcium is particulate calcium. Still further optionally, the source of calcium is milled calcium.
Optionally, the source of calcium is limestone. Further optionally, the source of calcium is particulate limestone. Still further optionally, the source of calcium is milled limestone.
Brief Description of the Drawings
Embodiments of the present invention will now be described with reference to the accompanying drawings and following non-limiting examples, in which:
Figure 1 illustrates the particle size distribution of the dry powder ingredient of interest;
Figure 2A illustrates the particle size distribution of the dietary composition;
Figure 2B compares the particle size distribution of the dry powder ingredient of interest and the dietary composition;
Figure 3 illustrates the effect on thermal properties of the dry powder ingredient of interest; and Figure 4 illustrates scanning electron microscopy analysis of the dietary composition.
Examples
Materials
Starch 1500® partially pregelatinised maize starch was commercially obtained from Colorcon. Microcrystalline cellulose 102 was commercially obtained from FMC Corporation. Limestone flour was obtained from Kilwaughter Chemical Company. A dry powder ingredient of interest was prepared in-house at Devenish Research Development and Innovation Limited.
Methods
The following dry materials were mixed together in a domestic food mixer from Kenwood: dry powder ingredient of interest (85.45% w/w), microcrystalline cellulose (6.81% w/w), limestone flour (6.81% w/w) and pregelatinised starch (0.91% w/w), unless otherwise stated.
Water was then slowly added whilst mixing until a weight of water equating to 20.45% of the total dry mass had been added.
Wet mass extrusion was performed using an Extruder 20 (Caleva, UK). The wet mass was gradually fed into a hopper, which is rotating at a speed of 15 rpm. The mass was forced through a 1 mm diameter die to form rod-shaped particles of uniform diameter. These particles were subsequently fed into a Spheroniser 120 (Caleva, UK) to produce spheres, with the spheroniser set at the highest possible speed setting. Granules were formed within 3-4 minutes. Granules were then left to dry in an oven at 37°C or left overnight to dry at room temperature.
Example 1
Particle size distribution of the dry powder ingredient of interest
The particle size distribution of the dry powder ingredient of interest was determined using sieve analysis. In short, a series of sieves ranging in sizes from 2000 pm to 45 pm was used, and a sample of the dry powder ingredient of interest was placed on top of the series of sieves and the series was then placed onto a shaking system in order to separate the dry powder ingredient of interest according to particle size.
As is evident from Figure 1 , there is a relatively wide particle size distribution within the dry powder ingredient of interest.
Example 2
Particle size distribution of the dietary composition
A dietary composition was prepared according to the general methods described herein.
The particle size distribution of each of the dry powder ingredient of interest and the dietary composition was determined using sieve analysis as described in Example 1 .
Figure 2A illustrates the particle size distribution of the dietary composition. For comparison purposes, the particle size distribution of the dietary composition and the dry powder ingredient of interest are directly compared in Figure 2B, which illustrates the dietary composition has a significantly reduced range of particle size, and the greatest proportion lies in the range of around 0.5 mm to 1 mm.
Example 3
Effect on thermal properties of the dry powder ingredient of interest
The thermal properties of the dry powder ingredient of interest were assessed to determine the effects a sterilisation process (usually of a temperature of about 80°C for about 6 minutes). As water is added in during the method of preparing the dietary composition, an initial heat and hold step was added in order to dry out the samples to allow for a more direct comparison. The thermal degradation temperature is taken as the temperature at which a 5% decrease in weight occurs. The thermal degradation temperature for the dry powder ingredient of interest was 227°C and the thermal degradation temperature for the dietary composition was 226°C, so there was statistically no difference between the thermal degradation temperatures, indicating that the method of preparing the dietary composition does not affect the thermal properties of the dry powder ingredient of interest.
Example 4
Imaging of the dietary composition A sample of the dietary composition was analysed using scanning electron microscopy. The granules of the dietary composition were seen to be relatively spherical, which should indicate good flowability.

Claims

Claims
1. A dietary composition comprising an ingredient of interest, the dietary composition comprising: (a) a dry mixture comprising:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture; and
(ii) the ingredient of interest; and
(b) water in an amount greater than 10%(w/w) relative to the dry mixture.
2. A dietary composition according to Claim 1 , wherein the dietary composition further comprises a source of calcium in an amount greater than 1%(w/w) of the dry mixture.
3. A dietary composition according to Claim 1 or 2, wherein the cellulose is microcrystalline cellulose.
4. A dietary composition according to Claim 2 or 3, wherein the source of calcium is particulate limestone.
5. A dietary composition according to any one of Claims 2 to 4, wherein the amount of cellulose and the amount of the source of calcium together form about 14%(w/w) of the dry mixture.
6. A dietary composition according to Claim 5, wherein the dietary composition comprises microcrystalline cellulose in an amount less than 7%(w/w) of the dry mixture; and particulate limestone in an amount greater than 7%(w/w) of the dry mixture.
7. A dietary composition according to Claim 5, wherein the dietary composition comprises water in an amount greater than 16%(w/w) relative to the dry mixture.
8. A dietary composition according to any preceding claim, wherein the composition further comprises starch in an amount less than 1 %(w/w) of the dry mixture.
9. A dietary composition according to Claim 8, wherein the starch is a pregelatinised starch.
10. A dietary composition according to Claim 9, wherein the dietary composition comprises: (a) a dry mixture comprising:
(i) microcrystalline cellulose in an amount of 7%(w/w) of the dry mixture;
(ii) particulate limestone in an amount of 7%(w/w) of the dry mixture;
(iii) pregelatinised starch in an amount of 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and (b) water in an amount of 20%(w/w) relative to the dry mixture.
11. A dietary composition according to any preceding claim, wherein the dietary composition is a granular composition.
12. A dietary composition according to Claim 11 , wherein the granules have a diameter of less than 1 mm.
13. A dietary composition according to Claim 11 or 12, wherein the granules are substantially spherical in form.
14. A dietary composition according to any one of Claims 11 to 13, wherein the granules have a substantially uniform particle size distribution.
15. A method of preparing the dietary composition according to the first aspect of the present invention, the method comprising the steps of:
(a) admixing:
(i) cellulose in an amount less than 15%(w/w) of the dry mixture; and
(ii) the ingredient of interest; and
(b) adding water in an amount greater than 10%(w/w) relative to the dry mixture.
16. A method according to Claim 15, wherein the method comprises:
(a) admixing:
(i) microcrystalline cellulose in an amount of 7%(w/w) of the dry mixture;
(ii) particulate limestone in an amount of 7%(w/w) of the dry mixture;
(iii) pregelatinised starch in an amount of 1%(w/w) of the dry mixture; and
(iv) the ingredient of interest; and
(b) adding water in an amount of 20%(w/w) relative to the dry mixture.
PCT/EP2020/088068 2019-12-31 2020-12-31 A dietary composition comprising an ingredient of interest Ceased WO2021136825A1 (en)

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Application Number Priority Date Filing Date Title
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2006009A (en) * 1977-09-02 1979-05-02 Eastman Kodak Co Medicinal or nutrient pellets for oral administration to ruminants
US4976976A (en) * 1988-04-07 1990-12-11 Mitsubishi Kasei Corporation Feed additive for ruminants
US20040166157A1 (en) * 2002-03-05 2004-08-26 Pfizer Inc Palatable controlled-released formulations for companion animals
US6989464B2 (en) * 2000-08-04 2006-01-24 Adisseo France S.A.S. Process for the preparation of granules of methionine
US20110183032A1 (en) * 2010-01-15 2011-07-28 Kemin Industries, Inc. Stomach-proected Alpha-amylase to Improve the Utilization of Diet Energy and Growth Performance of Animals
EP2941965B1 (en) * 2014-05-05 2019-02-27 DOX-AL ITALIA S.p.A. Coated animal feed

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2006009A (en) * 1977-09-02 1979-05-02 Eastman Kodak Co Medicinal or nutrient pellets for oral administration to ruminants
US4976976A (en) * 1988-04-07 1990-12-11 Mitsubishi Kasei Corporation Feed additive for ruminants
US6989464B2 (en) * 2000-08-04 2006-01-24 Adisseo France S.A.S. Process for the preparation of granules of methionine
US20040166157A1 (en) * 2002-03-05 2004-08-26 Pfizer Inc Palatable controlled-released formulations for companion animals
US20110183032A1 (en) * 2010-01-15 2011-07-28 Kemin Industries, Inc. Stomach-proected Alpha-amylase to Improve the Utilization of Diet Energy and Growth Performance of Animals
EP2941965B1 (en) * 2014-05-05 2019-02-27 DOX-AL ITALIA S.p.A. Coated animal feed

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