WO2021135782A1 - 一种基于涡旋对光束的光镊系统 - Google Patents

一种基于涡旋对光束的光镊系统 Download PDF

Info

Publication number
WO2021135782A1
WO2021135782A1 PCT/CN2020/132674 CN2020132674W WO2021135782A1 WO 2021135782 A1 WO2021135782 A1 WO 2021135782A1 CN 2020132674 W CN2020132674 W CN 2020132674W WO 2021135782 A1 WO2021135782 A1 WO 2021135782A1
Authority
WO
WIPO (PCT)
Prior art keywords
vortex
optical tweezers
particles
light modulator
optical
Prior art date
Application number
PCT/CN2020/132674
Other languages
English (en)
French (fr)
Inventor
王立刚
温积森
高斌杰
Original Assignee
浙江大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 浙江大学 filed Critical 浙江大学
Priority to US17/422,572 priority Critical patent/US11842825B2/en
Publication of WO2021135782A1 publication Critical patent/WO2021135782A1/zh

Links

Images

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
    • G21K1/006—Manipulation of neutral particles by using radiation pressure, e.g. optical levitation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/32—Micromanipulators structurally combined with microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/02—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/06—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the phase of light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0088—Inverse microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements

Definitions

  • the present invention relates to the field of optical technology, in particular to an optical tweezers system based on vortex pairing of light beams.
  • Optical tweezers technology is a technology that uses a strong focused laser beam as the light source.
  • the laser When the laser is irradiated on the particles, the laser will generate radiation force acting on the particles, thereby capturing and manipulating the particles.
  • the principle is relatively simple, that is, a laser beam is highly focused as the light source of the optical tweezers.
  • the focused beam will trap the particles through the formed potential well, and the particles can also be manipulated to achieve rotation and other operations.
  • the advantages of optical tweezers are still very prominent. In particular, optical tweezers do not need to contact the particles when manipulating the particles, which can avoid damage to the particles. This advantage is more prominent in the fields of biomedicine.
  • the initial optical manipulation is achieved by using the gradient force of the fundamental mode Gaussian beam.
  • these new structured light fields have also been used in optical capture operations.
  • the most typical is the vortex beam of Laguerre Gaussian beam.
  • the vortex beam is used as an optical tweezers, since the vortex beam carries orbital angular momentum during transmission, the vortex beam is strongly focused and irradiated on the particles, the exchange and transfer of angular momentum and momentum will occur between the vortex beam and the particles.
  • the analysis of the force angle is that the light beam exerts a force on the particles, which can control the rotation of the particles. Focusing the vortex beam highly creates a gradient force.
  • the action process of optical tweezers and particles is: the laser beam must first be focused, and then the focused light irradiates the particles to be acted upon. In this way, due to the existence of the particles, the beam interacts with the particles, and at the same time the orbital angular momentum of the beam changes. Because the action of the force is mutual, the particles get momentum from the beam, so they can move or rotate.
  • there are two kinds of forces one is gradient force, which refers to the force on the particles due to refraction, and the direction is pointing to the focus center of the beam; the other is the scattering force, which refers to the scattering force The force of the light beam on the particles due to reflection.
  • the direction of the scattering force is along the propagation direction of the captured beam.
  • the component of the gradient force in the lateral direction can pull the particles toward the focus center of the captured beam, and at the same time, another component of the gradient force, that is, the axial component, reaches a balance with the scattering force at a specific position of the focus center of the captured beam. In this way, the light beam can trap the particles in three dimensions.
  • the vortex beam Since the vortex beam has orbital angular momentum during its transmission, the interaction between the vortex beam and the particles will transfer momentum to the particles, so the particles will rotate. However, due to the existence of the orbital angular momentum, the orbital angular momentum of light will be transmitted to the particles, causing the particles to revolve on a bright ring. To some extent, this kind of rotation is uncontrollable, and it is undesirable for the manipulation of some particles.
  • the objects captured by the early optical tweezers are usually spherical, but it is difficult to capture non-spherical particles. If you want to realize the controllable capture of multi-particles or non-spherical particles such as rod-shaped particles with a single beam, there are usually disadvantages such as complex optical devices, difficult operation, and low controllability.
  • the invention aims to solve the problems in the prior art that the relative position control of the double particles cannot be achieved, and the directional rotation of the particles with special structures such as long strips cannot be achieved, and an optical tweezers system based on the vortex to the beam is provided.
  • the optical tweezers system can realize the precise adjustment and positioning of the relative position of two spherical particles in the plane, as well as the arbitrary controllable rotation operation in the rod-shaped particle plane, which makes the optical tweezers system richer in application objects and effectively solves the existing problems.
  • the optical tweezers system is difficult to control the rod-shaped particles.
  • the present invention provides an optical tweezers system based on vortex pairing beams, which includes a laser arranged according to the optical path, a collimated beam expansion system, a spatial light modulator, a confocal beam reduction system, a sample stage, and an observation unit ,
  • the said spatial light modulator continuously loads different vortex pair phase maps, outputs a single vortex pair beam, and realizes real-time control of particles;
  • ⁇ represents the phase
  • m 1 , m 2 are any two equal integers, called the topological charge
  • a represents the off-axis distance of the double vortex phase singular point, which is an arbitrary real number
  • u represents the abscissa
  • v represents the ordinate
  • I represents the imaginary unit.
  • the spatial light modulator Load the phase map calculated by formula (1) into the spatial light modulator, and the spatial light modulator outputs a single vortex paired beam. After the single vortex is used to focus the beam, there are two symmetrical capture areas in the focal plane, which can realize the pairing. Simultaneous capture of two particles.
  • the spatial light modulator continuously loads different vortex pair phase diagrams in real time to achieve Real-time precise control of the relative distance between two particles.
  • the distance between the two spots of the vortex pair beam at the focal plane can be increased, so that the distance between the two captured particles increases; when a becomes larger, the vortex On the contrary, the distance between the two spots of the light beam in the focal plane is reduced, and the distance between the two particles can be reduced.
  • the a is 0.1 to 1 times the waist radius of the incident beam incident on the spatial light modulator, and within this range, the off-axis distance a changes linearly with the distance between the particles.
  • a is 0.1 to 1 times the waist radius of the incident beam of the spatial light modulator.
  • the abscissa and ordinate in the vortex pair phase diagram are calculated according to formula (2):
  • u represents the abscissa
  • v represents the ordinate
  • u 0 represents the initial abscissa
  • v 0 represents the initial ordinate
  • ⁇ (t) represents the rotation angle, which is a function of time
  • t represents a time parameter.
  • the abscissa and ordinate can be rotated through formula (2), and the rotated coordinates are brought into formula (1) for calculation to obtain the rotated vortex phase diagram, which is loaded into the spatial light modulator to realize the capture of two particles Rotate the position in the plane, and then adjust the topological charges m 1 , m 2 or the off-axis distance a in the formula (1) to realize the change of the two particles at any angle and any relative distance in the plane; another On the one hand, by controlling the time parameter t or the speed at which the spatial light modulator loads the phase map, accurate control of the rotation speed and relative position change speed of the two particles can be achieved, and it has the characteristics of high accuracy, strong stability, and convenient operation.
  • the spatial light modulator is loaded with a vortex versus phase map, and a single vortex can also be used to focus the beam to have two symmetrical capture areas in the focal plane to achieve capture and lock of non-spherical particles such as rod-shaped particles.
  • the ⁇ (t) parameter in formula (2) is adjusted to realize the controllable directional rotation of rod-shaped particles, which solves the problem of directional rotation of particles with special structures such as non-spherical particles in the prior art, and the rotation speed can be adjusted and the accuracy is high. , Strong stability, which makes the optical tweezers system more abundant application objects.
  • the range of ⁇ (t) is 0 to 360 degrees, and the maximum rotational angular velocity is 60 degrees per second.
  • the collimated beam expanding system includes a half-wave plate, a polarization beam splitter prism, a total mirror, and a beam expander system in order according to the setting of the optical path;
  • the half-wave plate is fixed on a rotatable optical frame, and the polarization direction of the incident laser light is changed by rotating the half-wave plate around the optical axis;
  • the polarization beam splitting prism reflects s light and transmits p light through a dielectric beam splitting film to separate s-polarized light and p-polarized light; the optical power of the output light can be changed by rotating the half-wave plate in combination with the polarization beam splitting prism;
  • the total mirror is used to change the optical path and reflect the light beam to the beam expander system
  • the beam expander system expands the radius of the beam spot and realizes the collimation of the beam, which is conducive to covering the spot on the liquid crystal panel of the spatial light modulator, and makes full use of the modulation performance of the spatial light modulator;
  • the spatial light modulator is connected to a computer, and through the control program of the computer, the spatial light modulator is loaded with different vortex pair phase maps to realize precise control and positioning of the particles;
  • the confocal beam reduction system includes a first lens, a second lens, a beam splitter, and an objective lens in order according to the setting of the optical path; the first lens, the second lens and the beam splitter are used to modulate the vortex generated by the spatial light modulator
  • the beam spot is reduced so that all the spots can enter the aperture of the objective lens; the objective lens is used to converge the reduced spot on the sample stage; the sample stage is a two-dimensional electronically controlled translation stage, which can accurately find and locate the desired capture ⁇ particles;
  • the observation unit includes a visible light source, a focusing lens, and a CCD detector.
  • a filter is arranged in front of the focusing lens to filter the incident laser light so that the incident laser light does not affect the imaging of the CCD detector.
  • the half-wave plate can rotate around the optical axis.
  • the spatial light modulator is superimposed with a blazed grating phase diagram, and a diaphragm is provided behind the spatial light modulator.
  • the output power of the laser is more than 400 mW; the wavelength of the laser is 533-1064 nm.
  • the modulated light waveband of the spatial light modulator is 450 to 1064 nm.
  • the present invention discloses the following technical effects:
  • the optical tweezers system of the present invention can experiment with simultaneous capture of two particles using a single vortex to the beam. By adjusting the parameters of the phase diagram, the relative distance between the two particles can be achieved at any angle and direction in the plane. Real-time control of the position.
  • the optical tweezers system of the present invention rotates the light beam by rotating the loaded modulation phase diagram to realize the controllable and directional rotation of particles with special structures such as non-spherical particles, such as rod-shaped particles, at any angle in the plane, with high accuracy and strong stability.
  • the optical tweezers system of the present invention has simple design, high control accuracy, simple and flexible operation, and strong controllability of the trapping effect of particles, which greatly expands the application range of optical tweezers, especially for rod-shaped particles and other irregular shapes.
  • the capture of particles can be promoted and applied in the biological field.
  • Figure 1 is an optical path diagram of an optical tweezers system according to an embodiment of the present invention
  • the invention aims to solve the problems in the prior art that the relative position control of the double particles cannot be achieved, and the directional rotation of the particles with special structures such as long strips cannot be achieved, and an optical tweezers system based on the vortex to the light beam is provided.
  • the optical tweezers system can realize the precise adjustment and positioning of the relative position of two spherical particles in the plane, as well as the arbitrary controllable rotation operation in the rod-shaped particle plane, which makes the optical tweezers system richer in application objects and effectively solves the existing problems.
  • the optical tweezers system is difficult to control the rod-shaped particles.
  • Figure 1 shows an optical path diagram of an embodiment of the present invention. It includes a laser 1, a collimated beam expanding system, a spatial light modulator 6, a confocal beam reducing system, a sample stage 12 and an observation unit arranged according to the optical path.
  • the collimating beam expanding system includes a half-wave plate 2, a polarizing beam splitter 3, a total mirror 4, and a beam expander system 5 in sequence according to the setting of the optical path;
  • the confocal beam reduction system includes a first lens in sequence according to the setting of the optical path 8.
  • the observation unit includes a visible light source 13, a focusing lens 15, and a CCD detector 16.
  • Beam splitter 10 includes laser 1, half-wave plate 2, polarization beam splitter 3, total mirror 4, beam expander system 5, spatial light modulator 6, diaphragm 7, first lens 8, and second lens in sequence according to the optical path setting.
  • Beam splitter 10 objective lens 11, sample stage 12, visible light source 13, filter 14, focusing lens 15, CCD detector 16, and computer 17 connected to spatial light modulator 6.
  • the laser output from the laser 1 passes through the corresponding half-wave plate 2 with a wavelength of 533 nm.
  • the half-wave plate 2 is fixed on a rotatable optical frame, and the half-wave plate 2 rotates around the optical axis to change the polarization direction of the emitted light.
  • the output power of the laser is more than 400 mW; the wavelength of the laser is 533-1064 nm.
  • the laser light emitted through the half-wave plate 2 passes through the polarization beam splitting prism 3 to reflect s light, transmit p light, and emit p-polarized light, which meets the requirements of the spatial light modulator 6 for the polarization direction of the incident light.
  • the half-wave plate 2 can be rotated to control the light intensity of the laser light emitted by the polarization beam splitter 3.
  • the laser beam emitted from the polarization beam splitting prism 3 passes through the total mirror 4 to reflect the beam to the beam expander system 5; the beam expander system expands the laser spot diameter to as much as possible to cover the liquid crystal panel of the spatial modulator 6, thereby fully Use the spatial light modulator 6.
  • the modulated light waveband of the spatial light modulator 6 is 450 to 1064 nm, and the maximum modulation frequency is 120 Hz.
  • the laser beam expanded by the beam expander system 5 is incident on the spatial light modulator 6, and the spatial light modulator 6 is controlled by the computer 17 to load the designed vortex modulation phase diagram of the beam in real time, and superimpose the blazed grating phase diagram.
  • the computer 17 Through the control program of the computer 17, different vortex pair phase maps are loaded for the spatial light modulator 6 to realize precise control and positioning of the particles.
  • the spatial light modulator 6 superimposes the blazed grating phase diagram, and an aperture 7 is arranged behind the spatial light modulator 6, to improve the purity of the vortex to the beam in the light emitted by the spatial light modulator.
  • the vortex pair beam emitted by the spatial light modulator 6 selects the first-order diffracted light through the aperture 7 and blocks the light of other orders.
  • the first-order diffracted light is the target vortex pair beam, and then passes through the first lens 8.
  • the second lens 9 realizes the reduction of the beam radius, and realizes that all the light spots are incident on the aperture of the objective lens 11. Then it is reflected by the beam splitter 10 to reflect the vortex counter beam to the objective lens 11, and the vortex counter beam is focused on the sample to be tested on the sample stage 12 through the objective lens 11.
  • the sample stage 12 is a two-dimensional electronically controlled displacement stage, which can accurately To move and locate the captured particles.
  • the sample to be tested on the sample stage 12 is illuminated by a visible light source 13, filtered through the filter 14 and then focused and imaged on the CCD detector 16 by the focusing lens 15.
  • a filter 14 is arranged in front of the focusing lens 15 to filter the incident laser light so that the incident laser light does not affect the imaging of the CCD detector 16.
  • the laser 1 is a high-power semiconductor continuous laser with a wavelength of 533nm, and the maximum output power is 2W. This power can meet the requirements of capturing particles with sufficient trapping power.
  • Changchun Rayx Optoelectronics Technology, model MW-GL-532 is selected. /2000mW-16060208 laser.
  • the beam expander system 5 selects the GCO-25 series contact zoom beam expander of Daheng Optoelectronics, the model is GCO-2503.
  • the spatial light modulator 6 selects the PLUTO-2-VIS-056 model of Holoeye Company, the modulated light band is 450-650nm, and the reflectivity is greater than 93%.
  • the laser 1 emits a linearly polarized light beam with a wavelength of 533 nm. After passing through the half-wave plate 2 and the polarization beam splitting prism 3, the polarization direction of the light is horizontal polarization, and the half-wave plate 2 is rotated to adjust the light intensity for capturing particles.
  • the light beam enters the beam expander system 3 through the total mirror 4 to change the light propagation direction.
  • the beam expander system 3 expands the light beam by a factor of two, and the diameter of the expanded beam is about 3mm, which can cover the liquid crystal panel of the spatial light modulator 6.
  • the light beam expanded by the beam expander system 3 is incident on the spatial light modulator 6, and the spatial light modulator 6 is controlled by the computer 17, and the vortex phase diagram is loaded in real time.
  • the vortex pair beam modulated by the spatial light modulator 6 selects the first-order diffracted beam through the diaphragm 7, and the beam reduction ratio of the first lens 7 and the second lens 8 is 80%.
  • the contracted vortex beam is reflected by the beam splitter 10 into the objective lens 11, and the laser is concentrated in the sample to be tested on the sample stage 12, and the moving sample stage 12 can realize the movement of particles to complete the capture.
  • the visible light source 13 illuminates the sample to be tested on the sample stage 12, and the light passes through the filter 14 to filter the laser light with a wavelength of 533 nm, and is focused and imaged on the CCD detector 16 through the focusing lens 15.
  • the spatial light modulator 6 is controlled by the computer 17, and first loads the initial phase diagram of the vortex pair beam and superimposes the phase diagram of the blazed grating.
  • the first-order diffracted beam is selected through the diaphragm 7, and the first-order diffracted beam is what we need.
  • the vortex against the beam By loading the vortex phase diagram in real time, precise control and rotation of the double particles can be realized.
  • the vortex phase diagram is calculated by formula (1):
  • ⁇ represents the phase
  • m 1 , m 2 are any two equal integers, called the topological charge
  • a represents the off-axis distance of the phase singularity of the double vortex, which is an arbitrary real number
  • u represents the abscissa
  • v represents the ordinate
  • i represents the imaginary unit.
  • the optical tweezers system captures spherical particles as shown in Figure 4(a), adjust the phase diagram a can realize the controllable distance operation of two spherical particles in the lateral direction.
  • the optical tweezers system captures the spherical particles as shown in Figure 4(b) As shown, the lateral distance between the two particles is shortened.
  • Fig. 5 is a theoretical distribution diagram of the light intensity distribution on the focal plane after the vortex focuses the beam through a lens with a focal length of 500 mm.
  • ⁇ represents the phase
  • m 1 , m 2 are any two equal integers, called the topological charge
  • a represents the off-axis distance of the double vortex phase singular point, which is an arbitrary real number
  • u represents the abscissa
  • v represents the ordinate
  • I represents the imaginary unit.
  • u represents the abscissa
  • v represents the ordinate
  • u 0 represents the initial abscissa
  • v 0 represents the initial ordinate
  • ⁇ represents the rotation angle, which is a function of time
  • t represents the time parameter.
  • the range of ⁇ (t) is 0 to 360 degrees, which can realize the arbitrary rotation of the vortex to the beam in 360 degrees, including the external rotation angular velocity, or the rotation of particles with special structures such as non-spherical at any angle within 360; the maximum rotation angular velocity It is 60° per second.
  • phase maps with different rotation angles can be prepared to realize the controllable rotation of the rod-shaped particles.
  • the optical tweezers system has extremely high precision, strong stability and easy operation.

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microscoopes, Condenser (AREA)
  • Manipulator (AREA)

Abstract

一种基于涡旋对光束的光镊系统，包括按光路设置的激光器（1）、准直扩束系统、空间光调制器（6）、共焦缩束系统、样品台（12）和观测单元，空间光调制器（6）实时连续加载不同的涡旋对光束相位图，利用单一涡旋对光束对微粒实时操控和旋转。该光镊系统可以实现两个微粒在平面内任意位置的精准调控和定位，以及棒状微粒平面内任意可控的旋转操作，这使得该光镊系统的应用对象更加丰富，有效解决了现有光镊系统对棒状微粒难控制以及精准定向旋转的问题。

Description

一种基于涡旋对光束的光镊系统
本申请要求于2020年1月3日提交中国专利局、申请号为202010005566.9、发明名称为“一种基于涡旋对光束的光镊系统”的中国专利申请的优先权，其全部内容通过引用结合在本申请中。
技术领域
本发明涉及光学技术领域，特别是涉及一种基于涡旋对光束的光镊系统。
背景技术
光镊技术是利用一束强聚焦的激光光束作为光源，激光照射到粒子上时，激光会产生作用于粒子上的辐射力，从而捕获和操纵微粒的一项技术。其原理比较简单，就是把一束激光高度聚焦作为光镊的光源，聚焦后的光束就会通过形成的势阱把微粒捕获，也可以操控粒子实现转动等操作。和众多的微操纵技术相比，例如原子力显微镜、扫描探针显微镜等等，光镊的优势还是很突出。特别是光镊操控微粒时无需与微粒接触，这样可以避免对微粒造成伤害，这种优势在生物医学等领域更加突出。
最初的光学操纵是利用基模高斯光束的梯度力实现。随着一些新型的结构光场的出现，这些新的结构光场也被利用到光学捕获操作。最典型的就是拉盖尔高斯光束的涡旋光束。利用涡旋光束作为光镊时，由于涡旋光束在传输的过程中携带有轨道角动量，将涡旋光束强聚焦后照射粒子，会和粒子之间发生角动量和动量的交换和传递，从力的角度来分析就是光束给微粒施加了一个力，从而能够控制操控粒子旋转。把涡旋光束高度聚焦，会形成一个梯度力。这个力达到pN量级大小时，依靠这个力就可以把微粒牢牢地囚禁，也可以操纵粒子运动。同时由于强聚焦的光阱力，将微小粒子捕获在焦点附近，粒子呈悬浮状态，涡旋光束的中心光强为零，不会对微粒造成损伤，这一点相比传统的光镊是一个很大的优势。而利用涡旋光束作为光镊不仅可以捕获折射率大于周围介质的粒子，同时还能捕获折射率小于周围介质的粒子。
光镊和微粒的作用过程是：激光光束首先要聚焦，然后聚焦后的光照射到要作用的微粒上，这样由于微粒的存在，光束和微粒相互作用，同时 光束的轨道角动量发生了改变。因为力的作用是相互的，粒子从光束那里得到了动量，从而会运动或者旋转等。在作用的过程中，有两种力，一是梯度力，指的是由于折射而对粒子的作用力，方向则是指向光束的聚焦中心；还有一种力就是散射力，散射力指的是光束由于反射而对粒子的作用力。散射力的方向是沿着捕获光束的传播方向的。梯度力在横向上方向上的分量能够把微粒拉向捕获光束的聚焦中心，同时梯度力的另一个分量，也就是轴向分量在捕获光束的聚焦中心特定位置和散射力达到一个平衡。这样光束就可以在三维上把粒子囚禁了。
由于涡旋光束在传输的过程中带有轨道角动量，涡旋光束和粒子作用的过程就会传递动量给粒子，因此粒子会发生转动。但是由于轨道角动量的存在，光的轨道角动量会被传输到微粒上，导致微粒会亮环上公转，某种程度上，这种转动不可控，在一些微粒的操纵上并不希望出现。
早期的光镊捕获的对象通常是球形的，而对于非球形的微粒的捕获较为难以实现。若想实现单一光束对多粒子或者非球形微粒如棒状微粒等进行可操控的捕获时通常存在有光学装置复杂、操作难度大、可控性不高等缺点。
发明内容
本发明旨在解决现有技术中无法实现双微粒的相对位置调控，以及无法对长条形等特殊结构的微粒实现定向转动的问题，提供一种基于涡旋对光束的光镊系统。该光镊系统可以实现两个球形微粒在平面内相对位置的精准调控和定位，以及棒状微粒平面内任意可控的旋转操作，这使得该光镊系统的应用对象更加丰富，有效解决了现有光镊系统对棒状微粒难控制的问题。
为实现上述目的，本发明提供了一种基于涡旋对光束的光镊系统，包括按光路设置的激光器、准直扩束系统、空间光调制器、共焦缩束系统、样品台和观测单元，所述的空间光调制器连续加载不同的涡旋对相位图，输出单一涡旋对光束，实现微粒的实时操控；
所述的涡旋对相位图通过公式(1)计算：
Figure PCTCN2020132674-appb-000001
其中，φ表示相位，m 1,m 2为任意两个相等整数，称为拓扑荷数；a表示双涡旋相位奇异点的离轴距离，为任意实数；u表示横坐标；v表示纵坐标；i表示虚数单位。
将公式(1)计算的相位图加载至空间光调制器中，空间光调制器输出单一涡旋对光束，利用单一涡旋对光束聚焦后在焦平面具有两个对称的捕获区域，可实现对两个微粒的同时捕捉。通过调整公式(1)中的拓扑荷数m 1,m 2或离轴距离a，得到不同的涡旋对相位图，空间光调制器连续不断地实时加载不同的涡旋对相位图，可以实现两个微粒相对距离的实时精准控制。
当m 1,m 2同时增大时，可以增大涡旋对光束在焦平面双光斑之间的距离，从而使得捕捉到的两个微粒间的距离增大；当a变大时，涡旋对光束在焦平面双光斑之间的距离反而减小，可实现两个微粒间距离减小。
所述的a为入射到空间光调制器的入射光束腰半径的0.1～1倍，在该范围内，离轴距离a与微粒间距离的变化呈线性关系。
优选地，a为空间光调制器的入射光束腰半径的0.1～1倍。
优选地，所述的涡旋对相位图中横坐标和纵坐标根据公式(2)计算：
Figure PCTCN2020132674-appb-000002
其中，u表示横坐标；v表示纵坐标；u 0表示初始横坐标；v 0表示初始纵坐标；θ(t)表示旋转角度，为时间函数；t表示时间参数。
横、纵坐标经过公式(2)可实现旋转，将旋转后的坐标带入公式(1)进行计算得到旋转后的涡旋对相位图，加载至空间光调制器，可实现捕捉的两个微粒在平面内的位置旋转，再通过调整公式(1)内的拓扑荷数m 1,m 2或离轴距离a，即可实现两个微粒在平面内任意角度、任意相对距离的变化；另一方面，通过控制时间参数t或空间光调制器加载相位图的速度可实现两个微粒旋转速度、相对位置变化速度的准确控制，具有精度高，稳定性强，操作方便的特点。
本发明的光镊系统中空间光调制器加载涡旋对相位图，还可以利用单一涡旋对光束聚焦后在焦平面具有两个对称的捕获区域，实现非球形如棒状微粒的捕获和锁定。调整公式(2)中的θ(t)参数，实现棒状微粒的可控定向转动，解决了现有技术中对非球形等特殊结构的微粒实现定向转动的问题，且旋转速度可调控，精度高，稳定性强，这使得该光镊系统的应用对象更加丰富。
优选地，所述的θ(t)的范围为0到360度，最大旋转角速度为60°每秒。
优选地，所述准直扩束系统按照光路的设置依次包括半波片、偏振分光棱镜、全反镜、扩束镜系统；
所述半波片固定在可旋转的光学镜架上，通过半波片的绕光轴旋转改变入射激光的偏振方向；
所述偏振分光棱镜通过介质分束膜来反射s光透过p光，分离s偏振光和p偏振光；可通过旋转半波片，结合偏振分光棱镜，改变输出光的光功率；
所述全反镜用于改变光路，将光束反射至扩束镜系统；
所述扩束镜系统将光束光斑半径的扩大并实现光束的准直，有利于将光斑覆盖空间光调制器的液晶面板，充分利用空间光调制器的调制性能；
所述空间光调制器与计算机连接，通过计算机的控制程序，为空间光调制器加载不同的涡旋对相位图，实现对微粒的精准调控和定位；
所述共焦缩束系统按照光路的设置依次包括第一透镜、第二透镜、分束镜、物镜；第一透镜、第二透镜和分束镜用于将空间光调制器调制生成的涡旋对光束光斑缩小，使得全部光斑能进入物镜的孔径；物镜用于将缩小后的光斑会聚至所述样品台上；所述样品台为二维电控位移台，可精确寻找并定位所需捕获的微粒；
所述的观测单元包括可见光源、聚焦透镜、CCD探测器，所述的聚焦透镜前设有滤光片，对入射的激光进行滤光，使入射的激光不影响CCD探测器成像。
优选地，所述的半波片可绕光轴旋转。
优选地，所述的空间光调制器叠加闪耀光栅相位图，并在空间光调制 器后设有光阑。
优选地，所述的激光器的输出功率为400mW以上；所述的激光器波长为533～1064nm。
优选地，所述的空间光调制器的调制光波段为450～1064nm。
根据本发明提供的具体实施例，本发明公开了以下技术效果：
(1)本发明的光镊系统仅利用单一的涡旋对光束即可实验两个微粒的同时捕获，通过调整相位图的参数，可实现两个微粒的相对距离在平面内任意角度、任意方向的位置实时调控。
(2)本发明的光镊系统通过旋转加载的调制相位图来旋转光束，实现对非球形等特殊结构微粒，如棒状微粒平面内任意角度的可控定向旋转，精度高，稳定性强。
(3)本发明的光镊系统设计简单，控制精度高，操作简便灵活，对微粒的捕获效果可控性强，极大地拓展了光镊的应用范围，尤其是对于棒状微粒等形状不规则的微粒的捕获，可在生物领域的推广应用。
说明书附图
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动性的前提下，还可以根据这些附图获得其他的附图。
图1为本发明实施例光镊系统的光路图；
图2为a＝0.45mm，m 1＝6，m 2＝6时涡旋对相位图；
图3为a＝0.9mm，m 1＝6，m 2＝6时涡旋对相位图；
图4为光镊系统对两个球形微粒的捕获效果图，其中(a)a＝0.45mm；(b)a＝0.9mm；
图5为涡旋对光束经由焦距为500mm的透镜聚焦后在焦平面的光强分布理论分布图，m 1＝6，m 2＝6，a＝0.9mm；
图6为旋转120°后的涡旋对相位图，a＝0.9mm，m 1＝6，m 2＝6，θ(t)＝120°；
图7为光镊系统对棒状微粒的捕获效果图，其中(a)a＝0.9mm，m 1＝6，m 2＝6，θ(t)＝0°；(b)a＝0.9mm，m 1＝6，m 2＝6，θ(t)＝120°。
符号说明：1、激光器；2、半波片；3、偏振分光棱镜；4、全反镜；5、扩束镜系统；6、空间光调制器；7、光阑；8、第一透镜；9、第二透镜；10、分束镜；11、物镜；12、样品台；13、可见光源；14、滤光片；15、聚焦透镜；16、CCD探测器；17、计算机。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本发明旨在解决现有技术中无法实现双微粒的相对位置调控，以及无法对长条形等特殊结构的微粒实现定向转动的问题，提供一种基于涡旋对光束的光镊系统。该光镊系统可以实现两个球形微粒在平面内相对位置的精准调控和定位，以及棒状微粒平面内任意可控的旋转操作，这使得该光镊系统的应用对象更加丰富，有效解决了现有光镊系统对棒状微粒难控制的问题。
为使本发明的上述目的、特征和优点能够更加明显易懂，下面结合附图和具体实施方式对本发明作进一步详细的说明。
如图1所示为本发明实施例的光路图。包括按光路设置的激光器1、准直扩束系统、空间光调制器6、共焦缩束系统、样品台12和观测单元。所述准直扩束系统按照光路的设置依次包括半波片2、偏振分光棱镜3、全反镜4、扩束镜系统5；所述共焦缩束系统按照光路的设置依次包括第一透镜8、第二透镜9、分束镜10、物镜11；所述的观测单元包括可见光源13、聚焦透镜15、CCD探测器16。
具体的，按照光路设置依次包括激光器1，半波片2，偏振分光棱镜3，全反镜4，扩束镜系统5，空间光调制器6，光阑7，第一透镜8，第二透镜9，分束镜10，物镜11，样品台12，可见光光源13，滤光片14，聚焦透镜15，CCD探测器16以及和空间光调制器6连接的计算机17。
激光器1输出激光通过对应的533nm波长的半波片2，半波片2固定在可旋转光学镜架上，通过半波片2绕光轴旋转，改变出射光的偏振方 向。所述的激光器的输出功率为400mW以上；所述的激光器波长为533～1064nm。
经过半波片2出射的激光通过偏振分光棱镜3来反射s光透过p光，出射p偏振光，满足空间光调制器6对入射光偏振方向的要求。同时可旋转半波片2，控制偏振分光棱镜3出射激光的光强度。
从偏振分光棱镜3出射的激光经过全反镜4将光束反射至扩束镜系统5；扩束镜系统将激光的光斑直径扩大至其尽可能全部覆盖空间调制器6的液晶面元，从而充分利用空间光调制器6。空间光调制器6的调制光波段为450～1064nm，最大的调制频率为120Hz。
经扩束镜系统5扩束后的激光入射至空间光调制器6中，通过计算机17控制空间光调制器6实时加载设计好的涡旋对光束的调制相位图，并叠加闪耀光栅相位图。通过计算机17的控制程序，为空间光调制器6加载不同的涡旋对相位图，实现对微粒的精准调控和定位。空间光调制器6叠加闪耀光栅相位图，并在空间光调制器6后设有光阑7，提高空间光调制器出射光中涡旋对光束的纯度。
空间光调制器6出射的涡旋对光束通过光阑7挑选出一级衍射的光而挡住其他级次的光，一级衍射的光即为目标的涡旋对光束，再经第一透镜8和第二透镜9实现光束半径的缩小，实现光斑全部入射至物镜11的孔径。而后经过分束镜10反射至将涡旋对光束反射至物镜11，通过物镜11将涡旋对光束聚集到样品台12上的待测样品，样品台12为二维电控位移台，可精确地移动和定位所需捕获的微粒。
样品台12上的待测样品通过可见光光源13照亮，透过滤光片14滤光后由聚焦透镜15聚焦成像在CCD探测器16上。聚焦透镜15前设有滤光片14，对入射的激光进行滤光，使入射的激光不影响CCD探测器16成像。
以下实施例中激光器1为波长533nm的大功率半导体连续激光器，最大输出功率为2W，这种功率能够满足捕获微粒时具有足够的捕获力，选用长春雷仕光电科技，型号为MW-GL-532/2000mW-16060208的激光器。
扩束镜系统5选用大恒光电的GCO-25系列联系变倍扩束镜，型号为 GCO-2503。
空间光调制器6选用Holoeye公司的PLUTO-2-VIS-056型号的空间光调制器，调制光波段为450～650nm，反射率大于93％。
物镜11孔径NA＝1.25，放大倍数100倍，选用尼康，型号为CFI Achromat 100X OilAN.A.1.25的物镜；滤光片选用Thorlab FD1M型号滤光片。
实施例1
激光器1出射为波长533nm的线偏振光束，通过半波片2和偏振分光棱镜3后，光的偏振方向为水平偏振，旋转半波片2调整捕捉微粒合适的光强度。光束通过全反镜4改变光传播方向进入扩束镜系统3，扩束镜系统3对光束扩大2倍，扩束后的光斑直径约3mm，能够覆盖空间光调制器6的液晶面板。
经扩束镜系统3扩束后的光束入射至空间光调制器6，空间光调制器6通过计算机17控制，实时加载涡旋对相位图。经过空间光调制器6调制后的涡旋对光束，通过光阑7选择一级衍射光束，第一透镜7和第二透镜8的缩束，缩束比例为80％。
经缩束后的涡旋对光束经过分束镜10反射进入物镜11，激光聚集在样品台12上的待测样品中，移动样品台12可实现微粒移动完成捕获。可见光光源13对样品台12上的待测样品照明，光经过滤波片14将533nm波长的激光过滤，通过聚焦透镜15聚焦成像在CCD探测器16上。
空间光调制器6通过计算机17的控制，先加载涡旋对光束初始相位图并叠加闪耀光栅相位图，通过光阑7选择一级衍射光束，衍射出的一级衍射的光束即为我们所需要的涡旋对光束。通过实时加载涡旋对相位图，可以实现对双微粒的精确控制和旋转，涡旋对相位图通过公式(1)计算：
Figure PCTCN2020132674-appb-000003
φ表示相位，m 1,m 2为任意两个相等整数，称为拓扑荷数；a表示双涡旋相位奇异点的离轴距离，为任意实数；u表示横坐标；v表示纵坐标；i表示虚数单位。
涡旋对光束初始相位图如图2所示，其中a＝0.45mm，m 1＝6，m 2＝6；保持m 1,m 2不变，调整离轴距离参数a，不断增大至a＝0.9mm，涡旋对光束的相位图如图3所示，其中a＝0.9mm，m 1＝6，m 2＝6。
当空间光调制器加载的相位图中m 1＝6，m 2＝6，a＝0.45mm时，光镊系统对球形微粒的捕捉效果图如图4的(a)所示，调整相位图中a即可实现两个球形微粒在横向的可控距离操作，当m 1＝6，m 2＝6，a＝0.9mm时，光镊系统对球形微粒的捕捉效果图如图4的(b)所示，两个微粒间的横向距离缩短。
图5为涡旋对光束经由焦距为500mm的透镜聚焦后在焦平面的光强分布理论分布图，参数为m 1＝6，m 2＝6，a＝0.9mm。
实施例2
采用实施例1相同的光镊系统，空间光调制器加载的涡旋对相位图通过公式(1)计算：
Figure PCTCN2020132674-appb-000004
其中，φ表示相位，m 1,m 2为任意两个相等整数，称为拓扑荷数；a表示双涡旋相位奇异点的离轴距离，为任意实数；u表示横坐标；v表示纵坐标；i表示虚数单位。
涡旋对相位图中横坐标和纵坐标根据公式(2)计算：
Figure PCTCN2020132674-appb-000005
其中，u表示横坐标；v表示纵坐标；u 0表示初始横坐标；v 0表示初始纵坐标；θ表示旋转角度，为时间函数；t表示时间参数。
以m 1＝6，m 2＝6，a＝0.9mm，θ(t)＝0°的相位图作为初始相位图，光镊系统对棒状微粒的捕捉效果图如图7的(a)所示，棒状微粒呈水平横向；
调整公式(2)中旋转角度，当θ(t)＝120°，其他参数不变，旋转后的涡旋对相位图如图6所示；针对棒状微粒，即实现了微粒的可控定向转动，如图7的(b)所示，棒状微粒发生了逆时针120度的旋转。
θ(t)的范围为0到360度，可以实现涡旋对光束在360度的任意旋转 包括外在旋转角速度，或非球形等特殊结构的微粒在360内的任意角度的旋转；最大旋转角速度为60°每秒。改变时间参数t，可制备不同旋转角度的相位图，实现对棒状微粒的速度可控的旋转。该光镊系统具有极高的精度，且稳定性强，操作方便。
本说明书中各个实施例采用递进的方式描述，每个实施例重点说明的都是与其他实施例的不同之处，各个实施例之间相同相似部分互相参见即可。
本文中应用了具体个例对本发明的原理及实施方式进行了阐述，以上实施例的说明只是用于帮助理解本发明的方法及其核心思想；同时，对于本领域的一般技术人员，依据本发明的思想，在具体实施方式及应用范围上均会有改变之处。综上所述，本说明书内容不应理解为对本发明的限制。

Claims (10)

  1. 一种基于涡旋对光束的光镊系统，包括按光路设置的激光器、准直扩束系统、空间光调制器、共焦缩束系统、样品台和观测单元，其特征在于，所述的空间光调制器连续加载不同的涡旋对相位图，输出单一涡旋对光束，实现微粒的实时操控；
    所述的涡旋对相位图通过公式(1)计算：
    Figure PCTCN2020132674-appb-100001
    其中，φ表示相位，m 1,m 2为任意两个相等整数，称为拓扑荷数；a表示双涡旋相位奇异点的离轴距离，为任意实数；u表示横坐标；v表示纵坐标；i表示虚数单位。
  2. 根据权利要求1所述的基于涡旋对光束的光镊系统，其特征在于，a为空间光调制器的入射光束腰半径的0.1～1倍。
  3. 根据权利要求1所述的基于涡旋对光束的光镊系统，其特征在于，所述的涡旋对相位图中横坐标和纵坐标根据公式(2)计算：
    Figure PCTCN2020132674-appb-100002
    其中，u表示横坐标；v表示纵坐标；u 0表示初始横坐标；v 0表示初始纵坐标；θ(t)表示旋转角度，为时间函数；t表示时间参数。
  4. 根据权利要求3所述的基于涡旋对光束的光镊系统，其特征在于，所述的θ(t)的范围为0到360度，最大旋转角速度为60°每秒。
  5. 根据权利要求1所述的基于涡旋对光束的光镊系统，其特征在于，所述准直扩束系统按照光路的设置依次包括半波片、偏振分光棱镜、全反镜、扩束镜系统；
    所述共焦缩束系统按照光路的设置依次包括第一透镜、第二透镜、分束镜、物镜；
    所述的观测单元包括可见光源、聚焦透镜、CCD探测器。
  6. 根据权利要求5所述的基于涡旋对光束的光镊系统，其特征在于，所述的半波片可绕光轴旋转。
  7. 根据权利要求1所述的涡旋对光束的光镊系统，其特征在于，所 述的空间光调制器叠加闪耀光栅相位图，并在空间光调制器后设有光阑。
  8. 根据权利要求1所述的基于涡旋对光束的光镊系统，其特征在于，所述的激光器的输出功率为400mW以上；所述的激光器波长为533～1064nm。
  9. 根据权利要求1所述的基于涡旋对光束的光镊系统，其特征在于，所述的空间光调制器的调制光波段为450～1064nm。
  10. 根据权利要求5所述的基于涡旋对光束的光镊系统，其特征在于，
    所述半波片固定在可旋转的光学镜架上，通过半波片的绕光轴旋转改变入射激光的偏振方向；
    所述偏振分光棱镜通过介质分束膜来反射s光透过p光，分离s偏振光和p偏振光；可通过旋转半波片，结合偏振分光棱镜，改变输出光的光功率；
    所述全反镜用于改变光路，将光束反射至扩束镜系统；
    所述扩束镜系统将光束光斑半径的扩大并实现光束的准直；
    所述空间光调制器与计算机连接，通过计算机的控制程序，为空间光调制器加载不同的涡旋对相位图，实现对微粒的精准调控和定位；
    第一透镜、第二透镜和分束镜用于将空间光调制器调制生成的涡旋对光束光斑缩小，使得全部光斑能进入物镜的孔径；物镜用于将缩小后的光斑会聚至所述样品台上；所述样品台为二维电控位移台；
    所述的聚焦透镜前设有滤光片，对入射的激光进行滤光。
PCT/CN2020/132674 2020-01-03 2020-11-30 一种基于涡旋对光束的光镊系统 WO2021135782A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/422,572 US11842825B2 (en) 2020-01-03 2020-11-30 Vortex-pair beam based optical tweezer system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010005566.9 2020-01-03
CN202010005566.9A CN111175969B (zh) 2020-01-03 2020-01-03 一种基于涡旋对光束的光镊系统

Publications (1)

Publication Number Publication Date
WO2021135782A1 true WO2021135782A1 (zh) 2021-07-08

Family

ID=70649302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/132674 WO2021135782A1 (zh) 2020-01-03 2020-11-30 一种基于涡旋对光束的光镊系统

Country Status (3)

Country Link
US (1) US11842825B2 (zh)
CN (1) CN111175969B (zh)
WO (1) WO2021135782A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115185097A (zh) * 2022-09-14 2022-10-14 华东交通大学 一种用于产生贝塞尔艾里时空光场的装置与方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111175969B (zh) * 2020-01-03 2020-12-11 浙江大学 一种基于涡旋对光束的光镊系统
CN111899907B (zh) * 2020-08-10 2022-12-27 上海大学 一种输运装置
CN111999902B (zh) * 2020-09-10 2021-11-16 上海交通大学 一种飞秒激光双光子加工装置
CN114255903A (zh) * 2020-09-23 2022-03-29 山东师范大学 一种大容量粒子并行分拣装置及方法
CN113834764A (zh) * 2021-08-26 2021-12-24 桂林电子科技大学 一种用于微粒定向弹射的光纤来福枪系统及控制方法
US20230314299A1 (en) * 2022-03-14 2023-10-05 U.S. Army DEVCOM, Army Research Laboratory Optical trap using a focused hollow beam of unequal axisymmetry and no angular momentum for trapping and rotating airborne particles
CN116068784A (zh) * 2023-03-03 2023-05-05 福州大学 一种利用强散射介质进行激光抗振动聚焦装置及使用方法
CN116661134B (zh) * 2023-05-29 2023-11-21 南京理工大学 基于超透镜产生聚焦杂化偏振矢量光束的光链生成方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7433044B1 (en) * 2004-06-04 2008-10-07 University Of Hawaii Sagnac fourier transform spectrometer having improved resolution
CN103954367A (zh) * 2014-04-18 2014-07-30 河南科技大学 一种测量分数阶光学涡旋拓扑荷值的装置及其测量方法
CN103983367A (zh) * 2014-04-30 2014-08-13 河南科技大学 基于光强分析的分数阶涡旋光束拓扑荷值测量方法
CN105629454A (zh) * 2016-03-30 2016-06-01 中国计量学院 一种基于空间光调制器的双光束光镊系统
CN106908946A (zh) * 2016-05-05 2017-06-30 中国计量大学 一种简化的双光束光镊系统
CN111175969A (zh) * 2020-01-03 2020-05-19 浙江大学 一种基于涡旋对光束的光镊系统

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7324282B2 (en) * 2002-05-14 2008-01-29 Arryx, Inc. Apparatus, system and method for applying optical gradient forces
US7109473B2 (en) * 2002-09-16 2006-09-19 University Of Chicago Transverse optical accelerator and generalized optical vortices
WO2008127410A2 (en) * 2006-11-07 2008-10-23 New York University Holographic microfabrication and characterization system for soft matter and biological systems
US8174742B2 (en) * 2008-03-14 2012-05-08 New York University System for applying optical forces from phase gradients
WO2013046257A1 (ja) * 2011-09-28 2013-04-04 株式会社日立製作所 ゾーンプレート
IN2012DE00869A (zh) * 2012-03-24 2015-07-17 Director General Defence Res & Dev Org
US9474143B2 (en) * 2014-08-19 2016-10-18 University Of Dayton Systems and methods for generating complex vectorial optical fields
GB201707138D0 (en) * 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Machine learning analysis of nanopore measurements
CN107146649B (zh) * 2017-06-06 2019-04-12 东南大学 一种操控低折射率介质纳米粒子的装置和方法
CN107247329A (zh) * 2017-06-29 2017-10-13 中山大学 一种基于低数值孔径条件下的涡旋光摄装置和方法
US10587345B2 (en) * 2018-06-26 2020-03-10 University Of South Florida Measurement apparatus of vectorial optical fields
CN109188673B (zh) * 2018-09-14 2021-04-30 上海电力学院 一种可调的光镊装置
CN109828370B (zh) * 2019-01-24 2021-01-08 河南科技大学 一种镜像对称光学涡旋光阱掩模板的设计方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7433044B1 (en) * 2004-06-04 2008-10-07 University Of Hawaii Sagnac fourier transform spectrometer having improved resolution
CN103954367A (zh) * 2014-04-18 2014-07-30 河南科技大学 一种测量分数阶光学涡旋拓扑荷值的装置及其测量方法
CN103983367A (zh) * 2014-04-30 2014-08-13 河南科技大学 基于光强分析的分数阶涡旋光束拓扑荷值测量方法
CN105629454A (zh) * 2016-03-30 2016-06-01 中国计量学院 一种基于空间光调制器的双光束光镊系统
CN106908946A (zh) * 2016-05-05 2017-06-30 中国计量大学 一种简化的双光束光镊系统
CN111175969A (zh) * 2020-01-03 2020-05-19 浙江大学 一种基于涡旋对光束的光镊系统

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115185097A (zh) * 2022-09-14 2022-10-14 华东交通大学 一种用于产生贝塞尔艾里时空光场的装置与方法
CN115185097B (zh) * 2022-09-14 2022-12-06 华东交通大学 一种用于产生贝塞尔艾里时空光场的装置与方法

Also Published As

Publication number Publication date
CN111175969A (zh) 2020-05-19
CN111175969B (zh) 2020-12-11
US11842825B2 (en) 2023-12-12
US20220215980A1 (en) 2022-07-07

Similar Documents

Publication Publication Date Title
WO2021135782A1 (zh) 一种基于涡旋对光束的光镊系统
CN105629454B (zh) 一种基于空间光调制器的双光束光镊系统
US7151632B2 (en) Apparatus for production of an inhomogeneously polarized optical beam for use in illumination and a method thereof
CN104111590B (zh) 基于复合涡旋双瓣聚焦光斑的激光直写装置
CN108319028B (zh) 一种基于空心光尺寸调节的光镊操纵方法和装置
CN106908945B (zh) 一种基于光调制器的双光束光镊
CN106908946B (zh) 一种简化的双光束光镊系统
CN111273451B (zh) 一种大范围高精度移动圆艾里光束自聚焦点的装置及方法
CN105988261B (zh) 一种涡旋光场产生装置
CN108375836A (zh) 一种表面等离激元光镊装置
US11625001B1 (en) Optical system for generating arbitrary-order optical vortex arrays and finite optical lattices with defects
CN113959426A (zh) 一种用于原子干涉陀螺仪的拉曼光平行度调节装置及方法
CN103293679A (zh) 用于形成光学势阱的激光光束整形操控系统
CN113223744A (zh) 一种超快调控矢量涡旋光场的光学微操纵装置和方法
CN112731776B (zh) 一种双掩膜高通量激光超分辨激光直写方法和装置
CN109188673B (zh) 一种可调的光镊装置
Wang et al. New kind of Hermite–Gaussian-like optical vortex generated by cross phase
CN103235413A (zh) 一种利用相位板控制焦点位置方法
CN114527559B (zh) 基于单轴晶体的相衬显微模块、设备及方法
CN111239997A (zh) 一种基于交叉相位调制的快速对焦暗场成像装置及方法
Youngworth et al. Point spread functions for particle imaging using inhomogeneous polarization in scanning optical microscopy
CN218512724U (zh) 基于可调贝塞尔光束对液体中微粒捕获和操控装置
CN109581652A (zh) 一种基于磁液变形镜的光镊系统
CN117806048A (zh) 一种基于分数阶艾里涡旋光束的操纵微粒的方案
CN112799228B (zh) 一种单物镜成亚波长近球形焦点的系统及方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20910030

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20910030

Country of ref document: EP

Kind code of ref document: A1