WO2021134852A1 - 超声刺激人类语言神经中枢的系统 - Google Patents

超声刺激人类语言神经中枢的系统 Download PDF

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Publication number
WO2021134852A1
WO2021134852A1 PCT/CN2020/073213 CN2020073213W WO2021134852A1 WO 2021134852 A1 WO2021134852 A1 WO 2021134852A1 CN 2020073213 W CN2020073213 W CN 2020073213W WO 2021134852 A1 WO2021134852 A1 WO 2021134852A1
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language
ultrasound
ultrasonic
subsystem
user
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PCT/CN2020/073213
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English (en)
French (fr)
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谭力海
陈昕
邱士军
周玉龙
孙通
刘洁
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深圳市神经科学研究院
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Publication of WO2021134852A1 publication Critical patent/WO2021134852A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4803—Speech analysis specially adapted for diagnostic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/0026—Stimulation of nerve tissue

Definitions

  • the invention relates to the field of rehabilitation systems, in particular to a system for stimulating the human speech nerve center by ultrasound.
  • TFUS Transcranial Ultrasound Stimulation
  • the present invention aims to solve at least one of the technical problems existing in the prior art. For this reason, the present invention proposes a system for stimulating the human language nerve center by ultrasound, which can enhance the activity of the language function areas of the brain and improve the user's language ability.
  • an embodiment of the present invention provides: a system for ultrasonically stimulating the human speech nerve center.
  • the working mode includes: an ultrasonic acupoint stimulation mode and a language ability assessment mode, including:
  • Ultrasound control subsystem used to generate ultrasound signals according to ultrasound stimulation parameters, which act on the user's preset acupuncture points when in the ultrasound acupoint stimulation mode;
  • Language assessment subsystem used to evaluate the current language ability of the user in the language ability assessment mode, and get the rating result
  • Control subsystem used for task distribution and resource allocation, so that the ultrasound control subsystem and the language evaluation subsystem work together, and adjust the ultrasound stimulation parameters according to the rating results.
  • the preset acupoints include: Tongli acupoint and/or Xuanzhong acupoint.
  • the ultrasonic control subsystem includes: a signal generation module, a power amplification module, and an ultrasonic transducer;
  • the signal generating module generates a signal according to the ultrasonic stimulation parameter and sends it to the power amplifying module, and the power amplifying module power-amplifies the signal to drive the ultrasonic transducer to convert the power-amplified signal into Ultrasound signal.
  • the language assessment subsystem grades the user's language ability through a preset language ability task.
  • the preset language ability task includes a word naming task and/or a sentence comprehension task.
  • the language evaluation subsystem performs a language ability rating based on the result when the user completes the preset language ability task, and sends the rating result to the control subsystem.
  • ultrasonic stimulation parameters include: ultrasonic frequency, pulse repetition frequency, number of pulse cycles, pulse train length, pulse train interval, and train cycle number.
  • an abnormality management subsystem which is used to monitor the working status of the system and handle abnormal situations.
  • a display module for displaying information including acupoint guidance and language evaluation process, setting ultrasound stimulation parameters, and ultrasound parameter historical data.
  • the working mode of the system for stimulating the human speech nerve center by ultrasound of the present invention includes: ultrasound acupoint stimulation mode and language ability evaluation mode, the system includes: ultrasound control subsystem: used to generate ultrasound signals according to ultrasound stimulation parameters, when in the ultrasound acupoint stimulation mode The preset acupoints that act on the user at the same time; the language assessment subsystem: used to evaluate the current language ability of the user in the language ability assessment mode to obtain the rating results; the control subsystem: used to distribute tasks and allocate resources to make the The ultrasound control subsystem and the language evaluation subsystem work in coordination. Stimulation of specific acupoints by ultrasound changes the activation intensity of the language function area of the brain, enhances the function activity of the language function area of the brain, and evaluates the effect of improving language ability. At the same time, it replaces acupuncture and acupoint therapy, reduces the complexity of the operation, and does not rely on acupuncture treatment. Manual operation by skilled doctors has the advantages of non-invasiveness, automation and high efficiency.
  • Fig. 1 is a structural block diagram of Embodiment 1 of the system for ultrasonically stimulating the human speech nerve center in an embodiment of the present invention
  • Fig. 2 is a flow chart of the first embodiment of the system for stimulating the human speech nerve center by ultrasound in the embodiment of the present invention
  • Fig. 3 is a schematic diagram of the specific structure of the second embodiment of the system for stimulating the human speech nerve center by ultrasound in the embodiment of the present invention
  • Embodiment 4 is a schematic structural diagram of an ultrasound probe in Embodiment 2 of the system for ultrasonically stimulating the human speech nerve center in the embodiment of the present invention.
  • Acupuncture is an important part of traditional Chinese medicine. Studies have shown that acupuncture points such as Xuanzhong or Tongli can effectively regulate the neural activity of the brain's language center. Under normal circumstances, the acupuncture needles are inserted 15-25 mm into the skin points. Similar to acupuncture, the sound beam (approximately 4-6mm in diameter) generated by focused ultrasound pulses can directly act on the acupuncture points of the human body. Low-intensity focused ultrasound can stimulate the media to produce mechanical vibrations during the propagation of sound waves. For example, when it acts on nerve cells, it stimulates the cell membrane to generate mechanical vibrations and stretch the membrane composed of lipid bilayers, thereby realizing the simulation of the effect of acupuncture.
  • Acupuncture and moxibustion can significantly regulate the nervous system, while acupuncture at some acupoints can significantly regulate language functions.
  • Existing research suggests that changes in neurotransmitters may play an important role in the regulation of central nervous system by acupuncture and moxibustion. effect. Therefore, in this embodiment, ultrasound is used to simulate acupuncture points to cause changes in brain activity and perform non-invasive neuromodulation.
  • the first embodiment of the present invention provides a system for ultrasound stimulation of the human speech nerve center.
  • the working modes include: ultrasound acupoint stimulation mode and/or language ability assessment mode.
  • the two modes can be selected or coordinated, such as language alone.
  • Fig. 1 is a structural block diagram of a system for ultrasonically stimulating the human speech nerve center provided by an embodiment of the present invention. As shown in Fig. 1, the evaluation system includes the following functional components:
  • Ultrasound control subsystem 100 used to generate ultrasonic signals according to ultrasonic stimulation parameters, and act on the user's preset acupuncture points when in the ultrasonic acupoint stimulation mode.
  • Language assessment subsystem 200 used to evaluate the current language ability of the user in the language ability assessment mode to obtain a rating result.
  • the control subsystem 300 is used for task distribution and resource allocation, so that the ultrasound control subsystem and the language evaluation subsystem 200 coordinate their work, and adjust the ultrasound stimulation parameters according to the rating results.
  • the evaluation mode switching key 400 is used to switch the ultrasound acupoint stimulation mode or the language ability evaluation mode.
  • the display module 500 is used to display information including acupoint guidance, language evaluation process, setting ultrasonic stimulation parameters, and ultrasonic parameter historical data. For example, before using the evaluation, provide users with acupoint positioning guidance through graphics, video, etc., to assist The user can quickly and accurately find the preset acupuncture points of this embodiment when used alone.
  • Data storage module 600 used to store information such as the use log, ultrasonic stimulation parameters, preset language ability task evaluation of the system for stimulating the human speech nerve center by ultrasound.
  • Ultrasonic parameter adjustment knob 700 used to select various ultrasonic stimulation parameters, for example, by pressing and rotating the knob, each parameter item can be selected, and the parameter size can be adjusted by rotating the knob without pressing, and the ultrasonic pulse parameters can be adjusted at any time according to user needs.
  • Anomaly management subsystem 800 used to monitor the working status of the system and handle abnormal situations, such as loose connection of various connecting wires, poor communication of hardware components, insufficient system power supply voltage, insufficient system memory, storage, and excessive response time of each subsystem software Abnormal situations such as long or no response, downtime, and ultrasonic stimulation parameters higher than the safety threshold are monitored, and the power is turned off if necessary to ensure the normal operation of various functional components and the personal safety of users.
  • abnormal situations such as loose connection of various connecting wires, poor communication of hardware components, insufficient system power supply voltage, insufficient system memory, storage, and excessive response time of each subsystem software
  • Abnormal situations such as long or no response, downtime, and ultrasonic stimulation parameters higher than the safety threshold are monitored, and the power is turned off if necessary to ensure the normal operation of various functional components and the personal safety of users.
  • some functional components in this embodiment can operate independently without interfering with each other.
  • the abnormality management subsystem 800 and the control subsystem 300 realize the communication between the various components. Coordinate work and share data to achieve better evaluation results.
  • the language-related preset acupoints selected in this embodiment are: Tongli and Xuanzhong, where Tongli is located on the palm side of the forearm, when the radial edge of the flexor carpi ulnaris tendon is 1 cun above the transverse crease of the wrist;
  • the Xuanzhong point is located on the outside of the calf, 3 inches above the tip of the lateral malleolus, and on the front edge of the fibula.
  • control subsystem 300 may optionally be a microprocessor, which performs system task distribution and software and hardware resource allocation.
  • the ultrasound control subsystem 100 and the language ability assessment subsystem work together. , So that users can seamlessly connect ultrasound acupoint stimulation and language assessment.
  • the microcontroller performs operations such as language proficiency assessment, acupoint positioning guidance, and ultrasonic acupoint stimulation on the user according to the preset workflow, and makes reasonable adjustments so that the ultrasonic signal generated by the ultrasonic control subsystem 100 can achieve ultrasonic acupoint stimulation. Better results.
  • the control subsystem 300 has a preliminary understanding and positioning of the language ability of the current user, according to the user
  • the ultrasonic stimulation parameters are determined by the evaluation results of the, and the display device, such as the screen prompts the user to choose to enter the ultrasonic acupoint stimulation mode, the user can enter the corresponding mode through the corresponding mode switch button 400 (or knob) on the panel.
  • control subsystem 300 controls the language evaluation subsystem 200 to evaluate the current user's language ability to obtain the rating result is as follows:
  • the language evaluation subsystem 200 performs personalized ratings on the user's language through preset language ability tasks.
  • the preset language tasks include: word naming tasks and/or sentence comprehension tasks;
  • the language assessment subsystem 200 performs language ability ratings according to the feedback parameters when the user completes the preset language ability tasks, and sends the rating results to the control subsystem 300.
  • the preset language proficiency assessment tasks are:
  • the word naming task reads aloud according to the Chinese characters on the screen; 2) The sentence comprehension task requires the subjects to make a judgment based on the meaning of the sentence on the screen.
  • the ultrasound system for stimulating the human speech nerve center of this embodiment can be divided into five levels A, B, C, D, and E according to the language ability corresponding to the user evaluation results, corresponding to 90-100 points, 80-89 points, 70-79 points, 60-69 points and less than 60 points.
  • the score obtained is consistent with the number corresponding to the accuracy rate.
  • the system statistics accuracy rate is 90%
  • the user’s rating in the word naming is A (90-100 points)
  • the system obtains an accuracy rate of 85%
  • the user’s rating in the task is B (80 ⁇ 89 points), etc.
  • the preset language ability task can be set according to actual needs
  • the specific implementation method and scoring rules of, are not limited here.
  • the language ability rating method is simple and effective, and can accurately evaluate the user's language ability to a certain extent. When the corresponding result of a user evaluation process is poor (for example, the accuracy rate is less than 85%), it means that the user The function of performing this kind of language task is weak, and further intervention is needed. Therefore, the ultrasound stimulation parameters are adjusted according to the rating results.
  • the language ability scoring method of this embodiment is built in the language evaluation subsystem 200, and only counts the user's keypress or audio feedback results during the language evaluation, so as to obtain the corresponding rating results, and at the same time store the rating results in the data storage unit , Optional for privacy considerations, relevant users get results in read-only form.
  • the ultrasound control subsystem 100 in this embodiment includes: a signal generation module 110, a power amplification module 120, and an ultrasound transducer 130.
  • the signal generation module 110 generates a signal according to ultrasonic stimulation parameters and sends it to the power amplification module 120.
  • the power amplification module 120 amplifies the power of the signal to drive the ultrasonic transducer 130 to convert the amplified signal into an ultrasonic signal.
  • the power amplifying module 120 amplifies the output signal of the signal generating module 110 (for example, amplifies 10dB) to drive the ultrasonic transducer 130.
  • this module supports multi-channel output, which can generate different ultrasonic waves to stimulate different acupuncture points to achieve precision The effect of regulation.
  • the ultrasonic transducer 130 is equipped with a focused transducer chip, which uses magnetically compatible piezoelectric ceramic materials, which can convert the electrical signal of the power amplifier into ultrasonic waves, and accurately act on specific acupuncture points.
  • a focused transducer chip which uses magnetically compatible piezoelectric ceramic materials, which can convert the electrical signal of the power amplifier into ultrasonic waves, and accurately act on specific acupuncture points.
  • ultrasonic probes with different diameters can be selected, such as different sizes from 0.5cm to 1cm.
  • the ultrasound control system also has a built-in safety mechanism, which limits the ultrasound stimulation parameters and ensures that the user can perform ultrasound stimulation within a safe range.
  • the ultrasonic stimulation parameters are set with default values.
  • the user will perform a pain threshold measurement before each ultrasonic acupoint stimulation.
  • the measurement method is for the user to manually adjust each stimulus parameter so that it just reaches the tolerable sensory range, and the control subsystem 300 will calculate and save the sound intensity.
  • the user can also customize the settings through the parameter adjustment knob on the panel or make intelligent adjustments through the control subsystem 300, in order to avoid possible abnormal parameter settings, such as preventing excessive sound intensity (>30w/ cm 2 ) Acting on acupuncture points causes harm to the user.
  • the control subsystem 300 calculates the sound intensity in real time and limits the maximum possible value of each ultrasonic stimulation parameter. That is, when the sound intensity reaches the maximum, the user cannot continue to increase the value of each parameter.
  • the display module 500 At the same time, a pop-up warning is also carried out.
  • Specific ultrasonic stimulation parameters include: frequency (for example, the setting range is 0.1kHz ⁇ 5MHz), the ultrasonic frequency pulse repetition frequency (for example, the setting range is 0.1MHz ⁇ 1MHz), the number of pulse cycles (for example, the setting range is 100 ⁇ 300), Pulse train length (for example, the setting range is 10s ⁇ 60s), pulse train interval (for example, the setting range is 1s ⁇ 60s), the number of series cycles (for example, the setting range is 3 to 6 times), etc.
  • the adjustable ultrasonic frequency is 0.1W /cm 2 ⁇ 5W/cm 2 .
  • the default waveform is set as: a sine wave with a frequency of 0.5MHz, a pulse repetition frequency of 1000Hz, a pulse cycle number of 300, a pulse train length of 46s, a train interval of 30s, and a train cycle number of 4 times.
  • the above setting range is for reference only, and does not mean to limit the selection range of ultrasonic stimulation parameter values in this embodiment.
  • this embodiment can choose to automatically adjust only one parameter, such as pulse repetition frequency (pulse repetition frequency), of course, users
  • the parameter items that need to be adjusted automatically can be set to increase, decrease or replace.
  • This embodiment also includes some hardware components, such as: 1) keyboard: used for the user to input information; 2) touch button: the modified keyboard left and right direction keys, dedicated to receiving the user’s language evaluation response, the system can count users in real time 3) HDMI interface: used to expand the language evaluation display interface; 4) USB interface: used to read external language evaluation materials; 5) Probe interface: used to connect special probes for acupoints, equipped with probes of different specifications and Fixing device to meet the needs of different acupuncture points, users can easily complete the installation under video guidance. 6) Indicator light: used to indicate the working status of the probe; 7) Power interface: used to supply power to the system; 8) Microphone/headphone interface: used to connect microphones and headphones, input/output audio information.
  • ultrasonic acupoint stimulation mode When performing the ultrasonic acupoint stimulation mode, ultrasonic stimulation parameter settings are required.
  • FIG. 3 it is a schematic diagram of the specific structure of an embodiment of the system for stimulating the human speech nerve center by ultrasound in this embodiment.
  • the figure includes: screen 001, parameter adjustment knob 002, touch button 003, keyboard 004, mode switch button 005, power button 006, HDMI interface 007, USB interface 008, microphone 009, headset 010, power interface 011, probe interface 012, ultrasonic probe 013 and indicator light 017.
  • the structure diagram of the ultrasonic probe of this embodiment includes a cable 014, an ultrasonic transducer 015, and an elastic suction cup 016.
  • the treatment end surface of the probe ie the bottom surface of the suction cup 016) is sucked into the user’s skin through the elastic suction cup 016, and a little is applied.
  • the ultrasonic coupling agent can not only improve the contact effect between the skin and the end surface, but also strengthen the adsorption capacity of the elastic suction cup 016.
  • the working mode of the system for stimulating the human speech nerve center by ultrasound of the present invention includes: an ultrasound acupoint stimulation mode and a language ability assessment mode, and the system includes:
  • Ultrasound control subsystem used to generate ultrasound signals according to ultrasound stimulation parameters, which act on the user's preset acupuncture points when in the ultrasound acupoint stimulation mode;
  • Language assessment subsystem used to evaluate the current language ability of the user in the language ability assessment mode, and get the rating result
  • Control subsystem used for task distribution and resource allocation, so that the ultrasound control subsystem and the language evaluation subsystem work together.
  • Stimulation of specific acupoints by ultrasound changes the activation intensity of the language function area of the brain, enhances the function activity of the language function area of the brain, and evaluates the effect of improving language ability.
  • it replaces acupuncture and acupuncture points, reduces the complexity of the operation, and does not rely on acupuncture treatment.
  • Manual operation by skilled doctors has the advantages of non-invasiveness, automation and high efficiency.

Abstract

一种超声刺激人类语言神经中枢的系统，涉及康复系统领域，包括：超声调控子系统：用于根据超声刺激参数生成超声信号，当处于超声穴位刺激模式时作用于用户的预设穴位；语言评估子系统：用于在语言能力评估模式中，评估用户当前的语言能力，得到评级结果；控制子系统：用于进行任务分发和资源调配，使超声调控子系统、语言评估子系统协调工作，并根据评级结果调整超声刺激参数。

Description

超声刺激人类语言神经中枢的系统 技术领域
本发明涉及康复系统领域，尤其是涉及一种超声刺激人类语言神经中枢的系统。
背景技术
如今颅脑损伤较为常见，即便康复，严重的后遗症仍然影响患者的正常生活。现在常见的非侵入性神经调控技术，如经颅电刺激(tDCS或tACS)和经颅磁刺激(TMS)，可以通过增加或减少人脑的兴奋性来调节局部脑活动，进而达到治疗神经性疾病、促进健康人脑功能的目的，但这些技术在空间特异性和穿透深度上非常有限，难以达到良好的治疗效果。经颅超声刺激(TFUS)技术创造了一种可以无创地将超声声束传输到局部组织的方法，具有空间分辨率高、穿透性好等特点。在一系列动物实验中已经证明了聚焦超声对其大脑功能具有良好的调节作用，例如可以无创地调节小鼠、兔子、绵羊甚至健康的灵长类动物的大脑功能而不造成组织损伤。但是经颅超声刺激在健康人脑上很难实现，因为当超声声束通过人脑颅骨传输时，声束能量急剧下降，这将大大降低刺激效果。因此需要提出一种能够具有高空间分辨率、强穿透性，且能有效调节大脑语言神经中枢活性的超声刺激人类语言神经中枢的系统。
发明内容
本发明旨在至少解决现有技术中存在的技术问题之一。为此，本发明提出超声刺激人类语言神经中枢的系统，能够增强大脑语言功能区的活性，改善用户的语言能力。
第一方面，本发明的一个实施例提供了：一种超声刺激人类语言神经中枢的系统，工作模式包括：超声穴位刺激模式和语言能力评估模式，包括：
超声调控子系统：用于根据超声刺激参数生成超声信号，当处于超声穴位刺激模式时作用于用户的预设穴位；
语言评估子系统：用于在语言能力评估模式中，评估用户当前的语言能力，得到评级结果；
控制子系统：用于进行任务分发和资源调配，使所述超声调控子系统、所述 语言评估子系统协调工作，并根据所述评级结果调整所述超声刺激参数。
进一步地，所述预设穴位包括：通里穴和/或悬钟穴。
进一步地，所述超声调控子系统包括：信号发生模块、功率放大模块和超声换能器；
所述信号发生模块根据所述超声刺激参数产生信号发送给所述功率放大模块，所述功率放大模块将所述信号进行功率放大，以驱动所述超声换能器将功率放大后的信号转换为超声信号。
进一步地，所述语言评估子系统通过预设语言能力任务对用户语言能力进行评级，所述预设语言能力任务包括：字命名任务和/或句子理解任务。
进一步地，所述语言评估子系统根据用户完成所述预设语言能力任务时的结果进行语言能力评级，并将所述评级结果发送至所述控制子系统。
进一步地，所述超声刺激参数包括：超声频率、脉冲重复频率、脉冲周期数目、脉冲串长度、脉冲串间隔、串循环次数。
进一步地，还包括异常管理子系统，用于监控系统工作状态并处理异常情况。
进一步地，还包括显示模块，用于显示包括穴位指导和语言评估过程、设置超声刺激参数、超声参数历史数据在内的信息。
本发明的有益效果是：
本发明的超声刺激人类语言神经中枢的系统的工作模式包括：超声穴位刺激模式和语言能力评估模式，系统包括：超声调控子系统：用于根据超声刺激参数生成超声信号，当处于超声穴位刺激模式时作用于用户的预设穴位；语言评估子系统：用于在语言能力评估模式中，评估用户当前的语言能力，得到评级结果；控制子系统：用于进行任务分发和资源调配，使所述超声调控子系统、所述语言评估子系统协调工作。通过超声对特定穴位的刺激改变大脑语言功能区的激活强度，增强大脑语言功能区功能活性，评估达到改善语言能力的效果，同时取代针灸穴位治疗，降低操作复杂性，不依赖于进行针灸治疗的熟练医生的手动操作，具有无创性、自动化、效率高等优点。
附图说明
图1是本发明实施例中超声刺激人类语言神经中枢的系统实施例一的结构 框图；
图2是本发明实施例中超声刺激人类语言神经中枢的系统实施例一的使用流程图；
图3是本发明实施例中超声刺激人类语言神经中枢的系统实施例二的具体结构示意图
图4是本发明实施例中超声刺激人类语言神经中枢的系统实施例二的超声探头结构示意图。
具体实施方式
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对照附图说明本发明的具体实施方式。显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图，并获得其他的实施方式。
除非另有定义，本文所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本发明的说明书中所使用的术语只是为了描述具体的实施例的目的，不是旨在于限制本发明。
实施例一：
针灸是传统中医学的重要组成部分，研究证明针灸悬钟或通里等穴位可有效调节大脑语言中枢的神经活动。一般情况下，针灸针插入皮肤的穴位15-25毫米。与针刺相似，聚焦超声脉冲所产生的声束(直径约4-6mm)可将超声能量直接作用于人体穴位。低强度聚焦超声可以通过声波传播过程中激发受波作用媒质产生机械振动，如作用于神经细胞时激发细胞膜产生机械振动拉伸脂质双分子层构成的薄膜，从而实现对针灸效果的模拟。针灸法对神经系统可以起到显著的调节作用，而部分穴位的针灸能起到显著调节语言功能的作用，现有研究认为神经递质的变化在针灸对中枢神经的调节中可能起着重要的作用。因此本实施例中利用超声模拟针灸穴位从而引起大脑活动的改变，进行无创性神经调节。
本发明实施例一提供超声刺激人类语言神经中枢的系统，工作模式包括：超声穴位刺激模式和/或语言能力评估模式，其中两种模式可以择一选择，也可以进行配合选择，例如单独进行语言能力评估、单独进行超声穴位刺激。
图1为本发明实施例提供的超声刺激人类语言神经中枢的系统的结构框图， 如图1所示，该评估系统包括以下功能部件：
超声调控子系统100：用于根据超声刺激参数生成超声信号，当处于超声穴位刺激模式时作用于用户的预设穴位。
语言评估子系统200：用于在语言能力评估模式中，评估用户当前的语言能力得到评级结果。
控制子系统300：用于进行任务分发和资源调配，使超声调控子系统、语言评估子系统200协调工作，并根据评级结果调整超声刺激参数。
评估模式切换键400，用于切换超声穴位刺激模式或语言能力评估模式。
显示模块500，用于显示包括穴位指导、语言评估过程、设置超声刺激参数、超声参数历史数据在内的信息，例如在使用评估之前，通过图文、视频等方式为用户提供穴位定位指导，协助用户在独自使用的情况下，快速准确的找到本实施例的预设穴位。
数据存储模块600：用于存储该超声刺激人类语言神经中枢的系统的使用日志、超声刺激参数、预设语言能力任务评估等信息。
超声参数调节旋钮700：用于选择各项超声刺激参数，例如通过按压并旋转旋钮可以选择各参数项，无按压旋转旋钮可调整参数大小等，随时根据用户需要对超声脉冲参数进行调节。
异常管理子系统800：用于监控系统工作状态并处理异常情况，例如对诸如各连接线接合松动、硬件部件通讯不畅、系统电源电压不足、系统内存、存储不足、各子系统软件响应时间过长或无响应、宕机以及超声刺激参数高于安全阈值等异常情况进行监控，必要时将断电关机，保证各功能部件的正常运行以及用户的人身安全。
可以理解的是，本实施例中一些功能部件，例如语言评估子系统200、超声调控子系统100、可以独立运行互不干扰，通过异常管理子系统800、控制子系统300实现各部件之间的协调工作和共享数据，以达到更好的评估效果。
本实施例中选择的与语言相关的预设穴位为：通里穴和悬钟穴，其中通里穴位于前臂掌侧，当尺侧腕屈肌腱的桡侧缘，腕横纹上1寸；悬钟穴位于小腿外侧，当外踝尖上3寸，腓骨前缘。
下面具体描述各功能部件的工作原理。
本实施例中控制子系统300可选的为微处理器，进行系统任务分发与软硬件资源调配，在异常管理子系统800的监控下，使得超声调控子系统100、语言能力评估子系统协调工作，以便用户可以在超声穴位刺激和语言评估上进行无缝衔接。
同时，微控制器根据预设工作流程对用户进行语言能力评估以及穴位定位指导和超声穴位刺激等操作，对其进行合理调整，使得超声调控子系统100产生的超声信号进行超声穴位刺激时能够达到更好的效果。
无论是新用户还是旧用户，在使用本实施例的系统之前，均需要注册后进行当前状态下的语言能力评估，使得控制子系统300对当前用户的语言能力进行初步了解和定位后，根据用户的评估结果确定超声刺激参数，并通过显示装置，如屏幕提示用户选择进入超声穴位刺激模式，用户可以通过面板上对应的模式切换键400(或者旋钮)进入相应的模式中。
具体的，控制子系统300控制语言评估子系统200对当前用户进行语言能力评估得到评级结果的过程为：
语言评估子系统200通过预设语言能力任务对用户语言进行个性化评级，本实施例中，预设语言任务包括：字命名任务和/或句子理解任务；
语言评估子系统200根据用户完成预设语言能力任务时的反馈参数进行语言能力评级，并将评级结果发送至控制子系统300。
例如一个具体实施场景中，预设语言能力评估任务分别为：
1)字命名任务根据屏幕上的汉字进行出声阅读；2)句子理解任务要求被试根据对屏幕上句意做出是否判断。
本实施例的超声刺激人类语言神经中枢的系统根据用户评估结果对应的语言能力强弱依次可分成A、B、C、D、E五个等级，分别对应90～100分、80～89分、70～79分、60～69分和60分以下。
例如根据用户的结果准确率进行评分，得到的分数与准确率对应的数字一致，如用户字命名，系统统计的准确率是90％，那么用户在字命名的评级为A级(90～100分)，又比如，用户完成句子理解任务后，系统得到准确率为85％， 则用户在该任务中的评级为B级(80～89分)等，可以根据实际需要设定预设语言能力任务的具体实现方式和评分规则，在此不做限定。该语言能力评级方法简单有效，能在一定程度上对用户的语言能力做出准确地评价，当某个用户评估过程中对应的结果较差(比如准确率低于85％)，则说明该用户在进行该种语言任务的功能较弱，需要进一步的干预，因此根据评级结果调整超声刺激参数。
本实施例的语言能力评分方法内置于语言评估子系统200内，只对用户在进行语言评估时的按键或音频反馈结果进行统计，从而得到相应的评级结果，同时将评级结果存储于数据存储单元，可选的出于隐私考虑，相关用户通过只读形式获得结果。
进一步地，本实施例中超声调控子系统100包括：信号发生模块110、功率放大模块120和超声换能器130，信号发生模块110根据超声刺激参数产生信号发送给功率放大模块120，功率放大模块120将信号进行功率放大，以驱动超声换能器130将功率放大后的信号转换为超声信号。
功率放大模块120将信号发生模块110的输出的信号进行功率放大(例如放大10dB)，用来驱动超声换能器130，另外本模块支持多通道输出，能够产生不同的超声波刺激不同穴位，达到精准调控的效果。
超声换能器130配有聚焦式换能器片，采用磁兼容的压电陶瓷材料，能将功率放大器的电信号转换成超声波，并精准作用于特定的穴位。同时可选直径尺寸不同的超声探头，例如0.5cm至1cm等不同尺寸。
进一步地，超声调控系统还内置一个安全机制，该安全机制限制超声刺激参数，保证用户能在安全的范围内进行超声刺激。
例如一般情况下，采用默认值设置超声刺激参数，但因用户个体差异大，为避免因超声刺激而产生难以忍受的痛觉，用户在每次进行超声穴位刺激之前都先进行一次痛觉阈值的测量，测量方法为用户手动调节各刺激参数使得刚好达到可忍受的感觉范围内，控制子系统300将计算声强并保存。在超声穴位刺激模式下，用户也可通过面板上的参数调节旋钮自定义设置或通过控制子系统300进行智能化调节，为避免可能的参数设置异常，例如防止过高的声强(>30w/cm 2)作用于穴位导致对用户造成伤害，控制子系统300实时计算声强大小并限制各个超 声刺激参数可能的最大值，即声强达到最大时，用户无法继续增加各参数值，显示模块500也同时进行弹窗警告。
具体的超声刺激参数包括：频率(例如设置范围为0.1kHz～5MHz)、超声频率脉冲重复频率(例如设置范围为0.1MHz～1MHz)、脉冲周期数目(例如设置范围为100个～300个)、脉冲串长度(例如设置范围为10s～60s)、脉冲串间隔(例如设置范围为1s～60s)、串循环次数(例如设置范围为3次～6次)等，可调节的超声频率为0.1W/cm 2～5W/cm 2。可选的，如设置默认波形为：频率为0.5MHz的正弦波，脉冲重复频率为1000Hz，脉冲周期数目为300，脉冲串长度为46s，串间隔为30s，串循环次数为4次。
上述设置范围仅做参考示意，并不代表限定本实施例中超声刺激参数值的选择范围。
进一步地，因超声刺激参数较多，不同的参数配置效果也不同，且用户个体差异大，因此本实施例可以选择只对一个参数进行自动调节，如脉冲重复频率(脉冲重复频率)，当然用户可以设置选择增加、减少或更换需要自动调节的参数项。
本实施例还包括一些硬件部件，例如：1)键盘：用于用户输入信息；2)轻触按钮：经改造的键盘左右方向键，专用于接收用户的语言评估的反应，系统可实时统计用户的按键反馈；3)HDMI接口：用于拓展语言评估显示界面；4)USB接口：用于读取外部语言评估材料；5)探头接口：用于连接穴位专用探头，配置了不同规格的探头和固定装置，以满足不同的穴位需求，用户可在视频指导下轻松地完成安装。6)指示灯：用于指示探头的工作状态；7)电源接口：用于给系统供电；8)麦克风/耳机接口：用于连接麦克风和耳机，输入/输出音频信息。
上述仅仅给出本实施例一些常用硬件部件的示意，并不代表本实施例不包括上述硬件部件以外的部件。
如图2所示，为本实施例的使用流程图。
首先进行线路连接，如电缆和电源线等，然后开机进行该系统软硬件初始化和自检，然后获取用户登录或注册信息，对于新用户完善个人信息，然后进行语言能力初步评估，对于老用户，直接进去用户个人界面获取语言能力评估结果，模式选择：超声穴位刺激模式和/或语言能力评估模式，当进行超声穴位刺激模式时，需要进行超声刺激参数设置。
实施例二：
如图3所示，为本实施例的超声刺激人类语言神经中枢的系统一种实施方式具体结构示意图。
从图中可以看出，包括：屏幕001、参数调节旋钮002、轻触按钮003、键盘004、模式切换键005、电源按键006、HDMI接口007、USB接口008、麦克风009、耳机010、电源接口011、探头接口012、超声探头013和指示灯017。
如图4所示，为本实施例超声探头结构示意图，包括电缆014、超声换能器015和弹性吸盘016，探头治疗端面(即吸盘016底面)与用户皮肤通过弹性吸盘016吸合，涂抹少许超声耦合剂既可改善皮肤与端面接触效果也可加强弹性吸盘016的吸附能力。
其具体使用方法见实施例一的描述。
本发明的超声刺激人类语言神经中枢的系统的工作模式包括：超声穴位刺激模式和语言能力评估模式，系统包括：
超声调控子系统：用于根据超声刺激参数生成超声信号，当处于超声穴位刺激模式时作用于用户的预设穴位；
语言评估子系统：用于在语言能力评估模式中，评估用户当前的语言能力，得到评级结果；
控制子系统：用于进行任务分发和资源调配，使所述超声调控子系统、所述语言评估子系统协调工作。
通过超声对特定穴位的刺激改变大脑语言功能区的激活强度，增强大脑语言功能区功能活性，评估达到改善语言能力的效果，同时取代针灸穴位治疗，降低操作复杂性，不依赖于进行针灸治疗的熟练医生的手动操作，具有无创性、自动化、效率高等优点。
以上各实施例仅用以说明本发明的技术方案，而非对其限制，尽管参照前述各实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分或者全部技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的范围，其均应涵盖在本发明的权利要求和说明书的范围当中。

Claims (8)

  1. 一种超声刺激人类语言神经中枢的系统，其特征在于，工作模式包括：超声穴位刺激模式和语言能力评估模式，包括：
    超声调控子系统：用于根据超声刺激参数生成超声信号，当处于超声穴位刺激模式时作用于用户的预设穴位；
    语言评估子系统：用于在语言能力评估模式中，评估用户当前的语言能力，得到评级结果；
    控制子系统：用于进行任务分发和资源调配，使所述超声调控子系统、所述语言评估子系统协调工作，并根据所述评级结果调整所述超声刺激参数。
  2. 根据权利要求1所述的一种超声刺激人类语言神经中枢的系统，其特征在于，所述预设穴位包括：通里穴和/或悬钟穴。
  3. 根据权利要求1所述的一种超声刺激人类语言神经中枢的系统，其特征在于，所述超声调控子系统包括：信号发生模块、功率放大模块和超声换能器；
    所述信号发生模块根据所述超声刺激参数产生信号发送给所述功率放大模块，所述功率放大模块将所述信号进行功率放大，以驱动所述超声换能器将功率放大后的信号转换为超声信号。
  4. 根据权利要求1所述的一种超声刺激人类语言神经中枢的系统，其特征在于，所述语言评估子系统通过预设语言能力任务对用户语言能力进行评级，所述预设语言能力任务包括：字命名任务和/或句子理解任务。
  5. 根据权利要求4所述的一种超声刺激人类语言神经中枢的系统，其特征在于，所述语言评估子系统根据用户完成所述预设语言能力任务时的结果进行语言能力评级，并将所述评级结果发送至所述控制子系统。
  6. 根据权利要求1所述的一种超声刺激人类语言神经中枢的系统，其特征在于，所述超声刺激参数包括：超声频率、脉冲重复频率、脉冲周期数目、脉冲串长度、脉冲串间隔、串循环次数。
  7. 根据权利要求1所述的一种超声刺激人类语言神经中枢的系统，其特征在于，还包括异常管理子系统，用于监控系统工作状态并处理异常情况。
  8. 根据权利要求1至7任一项所述的一种超声刺激人类语言神经中枢的系统，其特征在于，还包括显示模块，用于显示包括穴位指导和语言评估过程、设置超声刺激参数、超声参数历史数据在内的信息。
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