WO2021125831A3 - 암 세포 검출용 발광 프로브 화합물 및 이를 포함하는 암 세포 검출용 발광 센서 - Google Patents

암 세포 검출용 발광 프로브 화합물 및 이를 포함하는 암 세포 검출용 발광 센서 Download PDF

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WO2021125831A3
WO2021125831A3 PCT/KR2020/018553 KR2020018553W WO2021125831A3 WO 2021125831 A3 WO2021125831 A3 WO 2021125831A3 KR 2020018553 W KR2020018553 W KR 2020018553W WO 2021125831 A3 WO2021125831 A3 WO 2021125831A3
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cancer cell
cell detection
luminescent
probe compound
same
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PCT/KR2020/018553
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English (en)
French (fr)
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WO2021125831A2 (ko
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김종승
손수빈
원미애
샤르마아밋
엘 세슬러조나단
샤밧도론
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고려대학교 산학협력단
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Publication of WO2021125831A2 publication Critical patent/WO2021125831A2/ko
Publication of WO2021125831A3 publication Critical patent/WO2021125831A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1007—Non-condensed systems

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

본 발명은 하기 [화학식 1]로 표시되는 암 세포 검출용 발광 프로브 화합물 및 이를 포함하는 암 세포 검출용 발광 센서에 관한 것이다: 본 발명에 따른 발광 프로브 화합물은 특히 NQO1이 과발현된 암 세포에 대해서 우수한 선택성으로 반응하며, 우수한 광물리적 특성과 낮은 세포독성을 가지고 있어 암 세포를 효과적으로 이미징할 수 있도록 한다.
PCT/KR2020/018553 2019-12-18 2020-12-17 암 세포 검출용 발광 프로브 화합물 및 이를 포함하는 암 세포 검출용 발광 센서 WO2021125831A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2019-0169480 2019-12-18
KR1020190169480A KR102332454B1 (ko) 2019-12-18 2019-12-18 암 세포 검출용 발광 프로브 화합물 및 이를 포함하는 암 세포 검출용 발광 센서

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WO2021125831A2 WO2021125831A2 (ko) 2021-06-24
WO2021125831A3 true WO2021125831A3 (ko) 2021-09-02

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KR (1) KR102332454B1 (ko)
WO (1) WO2021125831A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113861160B (zh) * 2021-10-26 2023-06-09 南京工业大学 一种一氧化碳气体检测化学发光探针、制备方法及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150104911A (ko) * 2014-03-07 2015-09-16 고려대학교 산학협력단 암 진단용 마커 및 이를 이용한 암 진단 방법
US20160025711A1 (en) * 2013-03-25 2016-01-28 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Fluorescent markers and methods for imaging diseases
CN108440369A (zh) * 2018-04-11 2018-08-24 淮北新思拓生物科技有限公司 一种肿瘤早期诊断探针及其合成和应用
KR20180108697A (ko) * 2016-01-26 2018-10-04 라모트 앳 텔-아비브 유니버시티 리미티드 진단 및 인비보 영상용 화학발광 프로브
KR20190012591A (ko) * 2017-07-28 2019-02-11 고려대학교 산학협력단 암 세포를 표적화하기 위한 소포체 선택적 형광 프로브 화합물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160025711A1 (en) * 2013-03-25 2016-01-28 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Fluorescent markers and methods for imaging diseases
KR20150104911A (ko) * 2014-03-07 2015-09-16 고려대학교 산학협력단 암 진단용 마커 및 이를 이용한 암 진단 방법
KR20180108697A (ko) * 2016-01-26 2018-10-04 라모트 앳 텔-아비브 유니버시티 리미티드 진단 및 인비보 영상용 화학발광 프로브
KR20190012591A (ko) * 2017-07-28 2019-02-11 고려대학교 산학협력단 암 세포를 표적화하기 위한 소포체 선택적 형광 프로브 화합물
CN108440369A (zh) * 2018-04-11 2018-08-24 淮北新思拓生物科技有限公司 一种肿瘤早期诊断探针及其合成和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUBIN SON, WON MIAE, GREEN ORI, HANANYA NIR, SHARMA AMIT, JEON YUKYOUNG, KWAK JONG HWAN, SESSLER JONATHAN L., SHABAT DORON, KIM JO: "Chemiluminescent Probe for the In Vitro and In Vivo Imaging of Cancers Over‐Expressing NQO1", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, DE, vol. 58, no. 6, 4 February 2019 (2019-02-04), DE, pages 1739 - 1743, XP055765240, ISSN: 1433-7851, DOI: 10.1002/anie.201813032 *

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WO2021125831A2 (ko) 2021-06-24
KR20210078594A (ko) 2021-06-29
KR102332454B1 (ko) 2021-11-29

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