WO2021118329A3 - 다중약물내성 극복을 위한 항암 약물전구체 - Google Patents

다중약물내성 극복을 위한 항암 약물전구체 Download PDF

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Publication number
WO2021118329A3
WO2021118329A3 PCT/KR2020/018292 KR2020018292W WO2021118329A3 WO 2021118329 A3 WO2021118329 A3 WO 2021118329A3 KR 2020018292 W KR2020018292 W KR 2020018292W WO 2021118329 A3 WO2021118329 A3 WO 2021118329A3
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Prior art keywords
cancer
multidrug resistance
prodrug
cancer prodrug
overcoming multidrug
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PCT/KR2020/018292
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English (en)
French (fr)
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WO2021118329A2 (ko
Inventor
김종승
장기리파라메시
원미애
심인섭
신진우
임문수
강철훈
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고려대학교 산학협력단
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Publication of WO2021118329A2 publication Critical patent/WO2021118329A2/ko
Publication of WO2021118329A3 publication Critical patent/WO2021118329A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 하기 [화학식 1]로 표시되는 화합물을 포함하는 항암 약물전구체에 관한 것이다: 본 발명에 따른 항암 약물전구체는 COX-2가 과발현된 암세포에 대해서 높은 선택성을 가지며, H 2O 2에 선택적으로 반응하여 효과적으로 두 가지 약물을 방출함으로써 다중약물내성 극복하고, 항암 효과를 향상시킬 수 있다.
PCT/KR2020/018292 2019-12-12 2020-12-14 다중약물내성 극복을 위한 항암 약물전구체 WO2021118329A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190165660A KR102326738B1 (ko) 2019-12-12 2019-12-12 다중약물내성 극복을 위한 항암 약물전구체
KR10-2019-0165660 2019-12-12

Publications (2)

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WO2021118329A2 WO2021118329A2 (ko) 2021-06-17
WO2021118329A3 true WO2021118329A3 (ko) 2021-07-29

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PCT/KR2020/018292 WO2021118329A2 (ko) 2019-12-12 2020-12-14 다중약물내성 극복을 위한 항암 약물전구체

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WO (1) WO2021118329A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022198325A1 (en) * 2021-03-26 2022-09-29 Tranmer Geoffrey K G Camptothecin (cpt) derivative(s) and methods and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100203150A1 (en) * 2009-02-06 2010-08-12 National Tsing Hua University Novel amphiphilic copolymers and fabrication method thereof
KR20180079452A (ko) * 2015-11-25 2018-07-10 주식회사 레고켐 바이오사이언스 자기-희생기를 포함하는 접합체 및 이의 제조방법
KR101990214B1 (ko) * 2017-12-12 2019-06-17 고려대학교 산학협력단 표적 특이적 항암 약물전구체

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100203150A1 (en) * 2009-02-06 2010-08-12 National Tsing Hua University Novel amphiphilic copolymers and fabrication method thereof
KR20180079452A (ko) * 2015-11-25 2018-07-10 주식회사 레고켐 바이오사이언스 자기-희생기를 포함하는 접합체 및 이의 제조방법
KR101990214B1 (ko) * 2017-12-12 2019-06-17 고려대학교 산학협력단 표적 특이적 항암 약물전구체

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALICIA J. SAWDON , JUN ZHANG , XUTU WANG , CHING-AN PENG: "Enhanced Anticancer Activity of 5’-DFUR-PCL-MPEG Polymeric Prodrug Micelles Encapsulating Chemotherapeutic Drugs", NANOMATERIALS, vol. 8, no. 12, 1041, 13 December 2018 (2018-12-13), pages 1 - 17, XP055830845, DOI: 10.3390/nano8121041 *
DELAHOUSSE J.; SKARBEK C.; PACI A.: "Prodrugs as drug delivery system in oncology", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 84, no. 5, 7 August 2019 (2019-08-07), pages 937 - 958, XP036906622, ISSN: 0344-5704, DOI: 10.1007/s00280-019-03906-2 *
JANGILI PARAMESH, WON MIAE, KIM SEO JIN, CHUN JIEUN, SHIM INSEOB, KANG CHULHUN, REN WEN XIU, KIM JONG SEUNG: "Binary drug reinforced first small-molecule-based prodrug for synergistic anticancer effects", 10TH SINGAPORE INTERNATIONAL CONFERENCE, vol. 2, no. 8, 19 August 2019 (2019-08-19), pages 3532 - 3539, XP055830850, ISSN: 2576-6422, DOI: 10.1021/acsabm.9b00418 *

Also Published As

Publication number Publication date
KR20210074689A (ko) 2021-06-22
WO2021118329A2 (ko) 2021-06-17
KR102326738B1 (ko) 2021-11-15

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