WO2021103493A1 - Procédé, système et appareil d'imagerie fondés sur les ondes de cisaillement - Google Patents

Procédé, système et appareil d'imagerie fondés sur les ondes de cisaillement Download PDF

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Publication number
WO2021103493A1
WO2021103493A1 PCT/CN2020/096261 CN2020096261W WO2021103493A1 WO 2021103493 A1 WO2021103493 A1 WO 2021103493A1 CN 2020096261 W CN2020096261 W CN 2020096261W WO 2021103493 A1 WO2021103493 A1 WO 2021103493A1
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shear wave
propagation
detection area
shear
energy
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PCT/CN2020/096261
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English (en)
Chinese (zh)
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刘德清
朱超超
冯乃章
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深圳开立生物医疗科技股份有限公司
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Publication of WO2021103493A1 publication Critical patent/WO2021103493A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/485—Diagnostic techniques involving measuring strain or elastic properties

Definitions

  • the present invention relates to the field of tissue lesion analysis, in particular to a shear wave-based imaging method, system and device.
  • Shear wave elastography technology based on acoustic radiation force is an ultrasonic elastography technology for evaluating tissue elasticity, and it is widely used in tissue lesion analysis.
  • the principle of shear wave elastography technology based on acoustic radiation force is: after the probe emits high-energy ultrasound to the tissue, under the action of the acoustic radiation force and the shear stress of the tissue, the tissue in a specific area will propagate to the surroundings. Because of the correlation between tissue hardness and shear wave speed, the tissue hardness can be analyzed by detecting the shear wave speed to determine whether there is tissue disease.
  • the principle of shear wave velocity detection is: at several observation points with a known distance of the forward propagation path of the shear wave, observe the time when the shear wave propagates to several observation points, and then according to The time difference between the shear wave propagation to several observation points and the space distance of several observation points, calculate the average velocity of the shear wave at these observation points. It can be seen that the prior art detects the forward propagation velocity of the shear wave from the excitation source of the shear wave. However, in the actual propagation process of the shear wave, due to the difference in the hardness of different tissues, the shear wave will be based on the hardness of the different tissues. The magnitude of the difference, different degrees of reflection occur. Since the prior art detects the shear wave velocity without considering the reflection that occurs during the propagation of the shear wave, the uniformity of the tissue hardness cannot be accurately analyzed, which is not conducive to the analysis of tissue lesions.
  • the purpose of the present invention is to provide a shear wave-based imaging method, system and device to obtain the shear wave propagation reflection coefficient of the shear wave detection area, so that the shear wave detection area can be accurately determined according to the shear wave propagation reflection coefficient
  • the uniformity of the tissue hardness is conducive to the analysis of regional tissue lesions.
  • the present invention provides a shear wave-based imaging method, including:
  • the shear wave propagation reflection coefficient According to the ratio of the reflected wave energy to the incident wave energy, obtain the shear wave propagation reflection coefficient, and return to the step of selecting a lateral local area in the shear wave detection area until the entire shear wave detection area is traversed, To obtain the shear wave propagation reflection coefficient of the entire shear wave detection area;
  • a tissue image characterizing the uniformity of the tissue hardness of the shear wave detection area is generated.
  • the process of selecting a lateral local area in the shear wave detection area and obtaining the incident wave energy and reflected wave energy of the shear wave corresponding to the lateral local area includes:
  • the process of periodically acquiring the tissue displacement of each detection point in the shear wave detection area under the action of the shear wave propagation includes:
  • the tissue displacement of each detection point under the propagation action of the shear wave is obtained according to the periodically obtained position information.
  • the process of obtaining the forward propagation information matrix and the backward propagation information matrix of the shear wave according to the two-dimensional time-space propagation matrix includes:
  • the forward propagation information matrix and the backward propagation information matrix are respectively extracted from the two-dimensional wk frequency domain matrix.
  • the process of correspondingly obtaining the incident wave energy and the reflected wave energy of the shear wave according to the forward propagation information matrix and the backward propagation information matrix includes:
  • the two-dimensional integration of the time frequency and the space frequency is performed on the absolute value of the back propagation information matrix to obtain the reflected wave energy of the shear wave.
  • the process of generating a tissue image characterizing the uniformity of the tissue hardness of the shear wave detection area according to the shear wave propagation reflection coefficient includes:
  • the imaging method further includes:
  • the shear wave propagation attenuation is corrected according to the reflected wave energy corresponding to the two adjacent lateral local regions.
  • the present invention also provides a shear wave-based imaging system, including:
  • An energy acquisition module configured to select a lateral local area in the shear wave detection area, and obtain the incident wave energy and the reflected wave energy of the shear wave corresponding to the lateral local area;
  • the coefficient obtaining module is used to obtain the shear wave propagation reflection coefficient according to the ratio of the reflected wave energy to the incident wave energy, and return to execute the energy obtaining module until the entire shear wave detection area is traversed to obtain The shear wave propagation reflection coefficient of the entire shear wave detection area;
  • the tissue imaging module is configured to generate a tissue image characterizing the uniformity of the tissue hardness of the shear wave detection area according to the shear wave propagation reflection coefficient.
  • the present invention also provides a shear wave-based imaging device, including:
  • Memory used to store computer programs
  • the processor is configured to implement the steps of any of the foregoing shear wave-based imaging methods when the computer program is executed.
  • the present invention provides an imaging method based on shear waves. Considering that in the actual propagation process of shear waves, due to the difference in the hardness of different tissues, the shear waves will have different degrees of hardness according to the difference in hardness of different tissues. Therefore, the reflection coefficient of shear wave propagation can directly and accurately reflect the uniformity of tissue hardness. Based on this, the present application obtains the shear wave propagation reflection coefficient of the shear wave detection area, so that the uniformity of the tissue hardness of the shear wave detection area can be accurately determined according to the shear wave propagation reflection coefficient, which is beneficial to the analysis of regional tissue lesions.
  • the present invention also provides a shear wave-based imaging system and device, which have the same beneficial effects as the foregoing imaging method.
  • FIG. 1 is a flowchart of a shear wave-based imaging method provided by an embodiment of the present invention
  • FIG. 2 is a diagram of a shear wave propagation waveform corresponding to a two-dimensional time-space propagation matrix provided by an embodiment of the present invention
  • FIG. 3 is a schematic diagram of a two-dimensional wk frequency domain matrix provided by an embodiment of the present invention.
  • FIG. 4 is a schematic diagram of a forward propagation information matrix provided by an embodiment of the present invention.
  • FIG. 5 is a schematic diagram of a backpropagation information matrix provided by an embodiment of the present invention.
  • FIG. 6 is a schematic structural diagram of a shear wave-based imaging system provided by an embodiment of the present invention.
  • the core of the present invention is to provide a shear wave-based imaging method, system and device to obtain the shear wave propagation reflection coefficient of the shear wave detection area, so that the shear wave detection area can be accurately determined according to the shear wave propagation reflection coefficient
  • the uniformity of the tissue hardness is beneficial to the analysis of regional tissue lesions.
  • FIG. 1 is a flowchart of a shear wave-based imaging method according to an embodiment of the present invention.
  • the shear wave-based imaging method includes:
  • Step S1 Select a lateral local area in the shear wave detection area, and obtain the incident wave energy and the reflected wave energy of the shear wave corresponding to the lateral local area.
  • the shear waves will be reflected to different degrees according to the difference in hardness of different tissues, so the shear waves occur during the propagation process.
  • the reflection situation can directly and accurately reflect the uniformity of the tissue hardness. More specifically, the greater the difference in hardness between two adjacent tissues, the greater the degree of reflection of the shear wave at the junction of the two tissues, that is, under the same incident wave energy, the greater the difference in hardness of the shear wave is. The greater the energy of the reflected wave at the junction of the two tissues.
  • the ratio of the reflected wave energy to the incident wave energy can be used, that is, the shear wave propagation reflection coefficient represents the reflection of the shear wave during the propagation process. Therefore, in this embodiment, in order to obtain the shear wave propagation reflection coefficient of a local tissue area, the incident wave energy and the reflected wave energy of the shear wave in the local tissue area should be obtained first.
  • shear wave detection area combining the shear wave propagation reflection coefficients of multiple lateral local areas of the shear wave detection area can directly and accurately determine the organization of the entire shear wave detection area Uniformity of hardness. More specifically, in this embodiment, in the shear wave detection area, a small section of the lateral local area is first selected, and then the incident wave energy and the reflected wave energy of the shear wave corresponding to the selected lateral local area are obtained. The shear wave propagation reflection coefficient of the selected lateral local area.
  • Step S2 According to the ratio of the reflected wave energy to the incident wave energy, obtain the shear wave propagation reflection coefficient, and determine whether to traverse the entire shear wave detection area, if not, return to the execution and select the lateral part in the shear wave detection area Step of the area; if yes, go to step S3.
  • the ratio of the reflected wave energy to the incident wave energy is calculated, thereby obtaining the shear wave energy of the selected lateral local area.
  • the present embodiment needs to traverse the entire shear wave detection area. If the entire shear wave detection area is not traversed, then continue to detect the shear wave that has not been traversed. Select a section of lateral local area in the area, and obtain the shear wave propagation reflection coefficient of this lateral local area according to the above steps; if the entire shear wave detection area has been traversed, the shear wave of the entire shear wave detection area can be obtained Propagation reflection coefficient.
  • the shear wave propagation reflection coefficient of each lateral local area may be different, and the shear wave propagation reflection coefficient of each lateral local area is determined by the tissue hardness of the lateral local area, that is, it has tissue elasticity. The uniqueness and referability of the detection, so as to detect the elasticity of the tissue more accurately.
  • Step S3 Generate a tissue image characterizing the uniformity of the tissue hardness in the shear wave detection area according to the shear wave propagation reflection coefficient.
  • this embodiment can generate a tissue image that clearly characterizes the uniformity of the tissue hardness of the shear wave detection area according to the shear wave propagation reflection coefficient of the entire shear wave detection area, so that the focus tissue can be found in time by analyzing the tissue image.
  • shear wave can be generated by acoustic radiation force, by external vibration, or by the internal motion tissue of the body.
  • the embodiment of the present invention provides a shear wave-based imaging method. Considering that in the actual propagation process of the shear wave, due to the difference in the hardness of different tissues, the shear wave will be different according to the difference in the hardness of the different tissues. Degree of reflection, so the shear wave propagation reflection coefficient can directly and accurately reflect the uniformity of tissue hardness. Based on this, the present application obtains the shear wave propagation reflection coefficient of the shear wave detection area, so that the uniformity of the tissue hardness of the shear wave detection area can be accurately determined according to the shear wave propagation reflection coefficient, which is beneficial to the analysis of regional tissue lesions.
  • the process of selecting a lateral local area in the shear wave detection area and obtaining the incident wave energy and reflected wave energy of the shear wave corresponding to the lateral local area includes:
  • the tissue displacement of each detection point in the shear wave detection area can reflect the shear wave in the shear wave detection area.
  • the energy transmission situation Therefore, in this embodiment, in order to understand the energy propagation of the shear wave in the shear wave detection area, periodically obtain the tissue displacement of each detection point in the shear wave detection area under the action of the shear wave propagation, and according to each detection point The one-dimensional time-displacement waveform of each detection point is obtained one by one of the tissue displacement.
  • the energy propagation of the shear wave in the entire shear wave detection area is specifically obtained by integrating the energy propagation of the shear wave in multiple lateral local areas within it.
  • the transverse direction is selected in the shear wave detection area.
  • the one-dimensional time displacement waveforms of the detection points in the selected lateral local area are combined to obtain the two-dimensional time-space propagation matrix corresponding to the lateral local area. Since the two-dimensional time-space propagation matrix corresponding to the lateral local area contains the forward propagation information matrix and the back-propagation information matrix of the shear wave in the lateral local area, this embodiment can be based on the two-dimensional time and space propagation corresponding to the lateral local area.
  • Matrix obtain the forward propagation information matrix and the reverse propagation information matrix of the shear wave in the lateral local area, and obtain the incident wave of the shear wave in the lateral local area according to the forward propagation information matrix of the shear wave in the lateral local area Energy, in the same way, the reflected wave energy of the shear wave in the lateral local area is obtained according to the back propagation information matrix of the shear wave in the lateral local area. Then use this technical means to traverse the entire shear wave detection area, so as to obtain the energy propagation of the shear wave in the entire shear wave detection area.
  • this embodiment analyzes the shear wave propagation waveform diagram corresponding to the two-dimensional time-space propagation matrix in Fig. 2 (the data at each position on the shear wave propagation waveform forms a two-dimensional time-space propagation matrix), and the shear wave reflection can be obtained.
  • the process of periodically acquiring the tissue displacement of each detection point in the shear wave detection area under the action of the shear wave propagation includes:
  • the tissue displacement of each detection point under the propagation of shear waves is obtained.
  • the technical means of this embodiment to obtain the tissue displacement of each detection point in the shear wave detection area under the action of the shear wave propagation is: first, according to the preset repetition frequency, repeatedly transmit to the shear wave detection area for detection.
  • the detection beam of the shear wave signal that is, the detection beam is periodically transmitted to the shear wave detection area.
  • the detection echo signal is received, and the multi-beam technology (a kind of radar overall technology for measuring target coordinates) is used to obtain the position information of each detection point in the shear wave detection area according to the returned detection echo signal.
  • the tissue displacement of the detection point in this period of time is based on the periodicity of each detection point. Time position information, the tissue displacement of each detection point that changes with time under the action of shear wave propagation is obtained.
  • the process of obtaining the forward propagation information matrix and the backward propagation information matrix of the shear wave according to the two-dimensional time-space propagation matrix includes:
  • the forward propagation information matrix and the backward propagation information matrix are respectively extracted from the two-dimensional wk frequency domain matrix.
  • the two-dimensional time-space propagation matrix is processed by the directional filter, that is, the two-dimensional time-space propagation matrix is subjected to 2D Fourier transform.
  • the two-dimensional wk frequency domain matrix that is, the two-dimensional time frequency-spatial frequency matrix, as shown in Figure 3.
  • the information matrix AMat of the second and fourth quadrants of the two-dimensional wk frequency domain matrix represents the forward propagation of the shear wave.
  • the information matrix BMat of the first quadrant and the third quadrant represents the information of the shear wave back propagation, so this embodiment can extract the forward propagation information matrix AMat from the two-dimensional wk frequency domain matrix respectively ( Figure 4) And the back-propagation information matrix BMat ( Figure 5).
  • this embodiment uses different masks to respectively extract the forward propagation information matrix AMat and the back propagation information matrix BMat in the two-dimensional wk frequency domain matrix, where the value of the mask: extract the forward propagation information matrix AMat
  • the first and third quadrants are set to 0 and the second and fourth quadrants are set to 1
  • the mask is multiplied by the two-dimensional wk frequency domain matrix to obtain the forward propagation information matrix AMat
  • the back propagation information matrix BMat is extracted, the first and third quadrants
  • the value is 1 and the value of the second and fourth quadrants is 0, then the mask is multiplied by the two-dimensional wk frequency domain matrix to obtain the back propagation information matrix BMat.
  • the process of correspondingly obtaining the incident wave energy and the reflected wave energy of the shear wave according to the forward propagation information matrix and the backward propagation information matrix includes:
  • the two-dimensional integration of time frequency and space frequency is performed on the absolute value of the backpropagation information matrix to obtain the reflected wave energy of the shear wave.
  • the calculation method for obtaining the incident wave energy Apower of the shear wave according to the forward propagation information matrix AMat is:
  • the calculation method for obtaining the reflected wave energy Bpower of the shear wave according to the backpropagation information matrix BMat is:
  • the process of generating a tissue image characterizing the uniformity of the tissue hardness of the shear wave detection area according to the shear wave propagation reflection coefficient includes:
  • the preset in this embodiment is set in advance, and only needs to be set once, unless it needs to be modified according to the actual situation, it does not need to be reset.
  • a range is set in advance: [min, max], so that the shear wave propagation reflection coefficients in the shear wave detection area are all normalized to the set range according to a certain rule, so that one One gets the normalized value of the reflection coefficient of shear wave propagation.
  • the correspondence relationship between the normalized value of the reflection coefficient and the color of the shear wave detection area is also set in advance, referred to as the coefficient color correspondence relationship.
  • the maximum value max corresponds to the color level 255
  • the minimum value min corresponds to the color level 0
  • the color level Rflct corresponding to the normalized value of the reflection coefficient RflctRatio is: In order to determine the color corresponding to the normalized value of the reflection coefficient.
  • the colors corresponding to the normalized values of the reflection coefficients are determined one-to-one according to the coefficient color correspondence relationship, and then the colors of the shear wave detection area are filled correspondingly according to each color. And control the display screen to display the shear wave detection area filled with the corresponding color for the staff to view, so as to more intuitively show the uniformity of the tissue hardness of the shear wave detection area.
  • gray values may represent different color levels; different colors may also represent different color levels.
  • the imaging method further includes:
  • the shear wave propagation attenuation is corrected according to the reflected wave energy corresponding to two adjacent lateral local areas.
  • ; the absolute value of the shear wave propagation attenuation is sequentially subtracted from the reflected wave energy of the adjacent transverse local areas A and B to obtain the corrected shear Shear wave propagation attenuation, that is, the corrected shear wave propagation attenuation
  • FIG. 6 is a schematic structural diagram of a shear wave-based imaging system provided by an embodiment of the present invention.
  • the shear wave-based imaging system includes:
  • the energy acquisition module 1 is used to select a lateral local area in the shear wave detection area, and obtain the incident wave energy and the reflected wave energy of the shear wave corresponding to the lateral local area;
  • the coefficient calculation module 2 is used to obtain the shear wave propagation reflection coefficient according to the ratio of the reflected wave energy to the incident wave energy, and return to the execution of the energy acquisition module until the entire shear wave detection area is traversed to obtain the entire shear wave detection The shear wave propagation reflection coefficient of the area;
  • the tissue imaging module 3 is used to generate a tissue image characterizing the uniformity of the tissue hardness in the shear wave detection area according to the shear wave propagation reflection coefficient.
  • An embodiment of the present application also provides a shear wave-based imaging device, including:
  • Memory used to store computer programs
  • the processor is used to implement the steps of any of the foregoing shear wave-based imaging methods when the computer program is executed.

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Abstract

L'invention concerne un procédé d'imagerie fondé sur les ondes de cisaillement. Au vu du processus de propagation effectif des ondes de cisaillement, en raison de la différence de dureté de différents tissus, les ondes de cisaillement seront réfléchies selon des degrés différents en fonction de la différence de dureté des différents tissus et, par conséquent, le coefficient de réflexion de la propagation des ondes de cisaillement peut refléter directement et avec précision l'uniformité de la dureté tissulaire. Sur cette base, selon le procédé d'imagerie fondé sur les ondes de cisaillement, le coefficient de réflexion de la propagation des ondes de cisaillement d'une zone de détection d'ondes de cisaillement est obtenu, de sorte que l'uniformité de la dureté tissulaire de la zone de détection des ondes de cisaillement peut être déterminée avec précision en fonction du coefficient de réflexion de la propagation des ondes de cisaillement, ce qui facilite l'analyse de lésions tissulaires locales. De plus, l'invention concerne également un système et un appareil d'imagerie fondés sur les ondes de cisaillement, qui présentent les mêmes effets avantageux que le procédé d'imagerie fondé sur les ondes de cisaillement.
PCT/CN2020/096261 2019-11-27 2020-06-16 Procédé, système et appareil d'imagerie fondés sur les ondes de cisaillement WO2021103493A1 (fr)

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CN111449681B (zh) * 2020-04-08 2023-09-08 深圳开立生物医疗科技股份有限公司 一种剪切波成像方法、装置、设备及可读存储介质
CN113243889B (zh) * 2020-08-10 2022-05-10 北京航空航天大学 获取生物组织的信息的方法和设备
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