WO2021101351A3 - 비푸코실화된 담배를 이용하여 생산한 항체 및 이의 용도 - Google Patents

비푸코실화된 담배를 이용하여 생산한 항체 및 이의 용도 Download PDF

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Publication number
WO2021101351A3
WO2021101351A3 PCT/KR2020/016605 KR2020016605W WO2021101351A3 WO 2021101351 A3 WO2021101351 A3 WO 2021101351A3 KR 2020016605 W KR2020016605 W KR 2020016605W WO 2021101351 A3 WO2021101351 A3 WO 2021101351A3
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WO
WIPO (PCT)
Prior art keywords
afucosylated
tobacco
present
sugar chain
antibody
Prior art date
Application number
PCT/KR2020/016605
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English (en)
French (fr)
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WO2021101351A2 (ko
WO2021101351A9 (ko
Inventor
최성화
천지녕
최수민
박종진
최선미
김해림
Original Assignee
(주)지플러스 생명과학
서울대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by (주)지플러스 생명과학, 서울대학교산학협력단 filed Critical (주)지플러스 생명과학
Publication of WO2021101351A2 publication Critical patent/WO2021101351A2/ko
Publication of WO2021101351A3 publication Critical patent/WO2021101351A3/ko
Publication of WO2021101351A9 publication Critical patent/WO2021101351A9/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 비푸코실화된 담배를 이용하여 생산한 항체 및 이의 용도에 관한 것이다. 본 발명에 따른 비푸코실화된 담배를 이용하여 생산한 항체는 기존의 동물세포를 이용하여 생산한 항체와 다른 형태의 당쇄를 가지며, 항체의 당쇄에 푸코스가 존재하지 않는 것을 확인하였다. 또한, 본 발명에 따른 변형된 당쇄를 갖는 항체가 기존의 동물세포를 이용하여 생산한 항체보다 우수한 항암효과를 나타내는 것을 확인하였다. 따라서, 본 발명에 따른 변형된 당쇄를 갖는 항체는 암의 예방 또는 치료에 유용하게 사용될 수 있다.
PCT/KR2020/016605 2019-11-21 2020-11-23 비푸코실화된 담배를 이용하여 생산한 항체 및 이의 용도 WO2021101351A2 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2019-0150743 2019-11-21
KR20190150743 2019-11-21
KR10-2019-0168128 2019-12-16
KR20190168128 2019-12-16

Publications (3)

Publication Number Publication Date
WO2021101351A2 WO2021101351A2 (ko) 2021-05-27
WO2021101351A3 true WO2021101351A3 (ko) 2021-07-22
WO2021101351A9 WO2021101351A9 (ko) 2021-09-02

Family

ID=75981393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2020/016605 WO2021101351A2 (ko) 2019-11-21 2020-11-23 비푸코실화된 담배를 이용하여 생산한 항체 및 이의 용도

Country Status (1)

Country Link
WO (1) WO2021101351A2 (ko)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080094918A (ko) * 2006-01-17 2008-10-27 바이오렉스 쎄라퓨틱스, 인코포레이티드 식물에서 ｎ-글리칸의 인간화 및 최적화 조성물 및 방법
KR20090039756A (ko) * 2006-07-11 2009-04-22 그리노파티온 바이오테크 게엠베하 당­조작 항체
JP2014531903A (ja) * 2011-10-04 2014-12-04 アイコン・ジェネティクス・ゲーエムベーハー フコシルトランスフェラーゼ活性が欠損したニコチアナ・ベンサミアナ植物
US20170283822A1 (en) * 2014-11-20 2017-10-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lt Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
US20180171028A1 (en) * 2015-05-13 2018-06-21 Zumutor Biologics, Inc. Afucosylated protein, cell expressing said protein and associated methods
JP2019033749A (ja) * 2012-11-01 2019-03-07 セレクティス 治療用タンパク質の生産のための植物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080094918A (ko) * 2006-01-17 2008-10-27 바이오렉스 쎄라퓨틱스, 인코포레이티드 식물에서 ｎ-글리칸의 인간화 및 최적화 조성물 및 방법
KR20090039756A (ko) * 2006-07-11 2009-04-22 그리노파티온 바이오테크 게엠베하 당­조작 항체
JP2014531903A (ja) * 2011-10-04 2014-12-04 アイコン・ジェネティクス・ゲーエムベーハー フコシルトランスフェラーゼ活性が欠損したニコチアナ・ベンサミアナ植物
JP2019033749A (ja) * 2012-11-01 2019-03-07 セレクティス 治療用タンパク質の生産のための植物
US20170283822A1 (en) * 2014-11-20 2017-10-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Lt Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
US20180171028A1 (en) * 2015-05-13 2018-06-21 Zumutor Biologics, Inc. Afucosylated protein, cell expressing said protein and associated methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JANSING JULIA, SACK MARKUS, AUGUSTINE SRUTHY MARIA, FISCHER RAINER, BORTESI LUISA: "CRISPR/Cas9-mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β-1,2-xylose and core α-1,3-fucose", PLANT BIOTECHNOLOGY JOURNAL, BLACKWELL PUB., GB, vol. 17, no. 2, 1 February 2019 (2019-02-01), GB, pages 350 - 361, XP055829919, ISSN: 1467-7644, DOI: 10.1111/pbi.12981 *

Also Published As

Publication number Publication date
WO2021101351A2 (ko) 2021-05-27
WO2021101351A9 (ko) 2021-09-02

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