WO2021099195A1 - Dispositif d'oxygénateur - Google Patents

Dispositif d'oxygénateur Download PDF

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Publication number
WO2021099195A1
WO2021099195A1 PCT/EP2020/081777 EP2020081777W WO2021099195A1 WO 2021099195 A1 WO2021099195 A1 WO 2021099195A1 EP 2020081777 W EP2020081777 W EP 2020081777W WO 2021099195 A1 WO2021099195 A1 WO 2021099195A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
blood
cannula
pump membrane
hollow fibers
Prior art date
Application number
PCT/EP2020/081777
Other languages
German (de)
English (en)
Inventor
Thomas Schmitz-Rode
Sascha Groß-Hardt
Jutta Arens
Ulrich Steinseifer
Original Assignee
Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen filed Critical Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen
Publication of WO2021099195A1 publication Critical patent/WO2021099195A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/303—Details having a reservoir for treated blood to be returned
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/304—Treatment chamber used as reservoir, e.g. centrifuge bowl or filter with movable membrane

Definitions

  • the invention relates to an oxygenator device comprising a housing which can be filled with blood and in which material-permeable hollow fibers are arranged, the interior of which can be flowed through by a gas and on the outside by blood.
  • Oxygenators of this type are known in principle in the prior art. The following statements - unless otherwise stated - apply equally to the oxygenators of the prior art and of the invention.
  • the oxygenators serve to enrich a patient's blood with oxygen and to deplete it of carbon dioxide, for which purpose a gas with suitable partial pressures of oxygen and carbon dioxide flows through the hollow fibers, around which the patient's blood flows on the outside.
  • the hollow fibers are semipermeable, in particular in the sense that oxygen and carbon dioxide can pass through the hollow fiber walls in opposite directions, but the hollow fiber walls are impermeable to the other blood components.
  • a material exchange, in particular a gas exchange, between the blood flowing past on the outside and the gas flowing inside can thus take place across the hollow fiber walls.
  • the hollow fibers are usually linearly extended, the end regions of the hollow fibers, which lie on a common side, being tightly glued to one another and to the housing, which is also referred to as potting.
  • the gas can be introduced into the fibers through the open ends of the hollow fibers via gas inlet and outlet areas which connect to the potted end areas and can be discharged at the opposite end.
  • the hollow fibers typically form a package which is arranged in the interior of the housing of the oxygenator device.
  • Such a package can e.g. B. be designed as a stack or as a winding of at least one hollow fiber mat, preferably a plurality of hollow fiber mats, in particular wherein the hollow fibers are stabilized in position in a respective mat with warp threads.
  • these can all have only one direction or also intersecting directions (angles of 0 ° - 90 ° possible).
  • the hollow fibers of different layers of a stack or a roll can differ in direction from one another.
  • the walls of the hollow fibers separate the volume of the housing into two areas, namely the area that includes the blood and the area through which gas flows.
  • the gas area is given at least by the sum of all volumes in the interior of the hollow fibers.
  • the blood area is given by the volume in the housing that is arranged around the hollow fibers.
  • a housing of an oxygenator has a blood inlet and a blood outlet. Both the blood inlet and the blood outlet are each connected to the blood circulation of a patient to be treated via a separate cannula.
  • the blood is taken from the blood circulation by means of one of the two cannulas and, after a treatment in the oxygenator, is returned to the blood circulation by means of the other cannula.
  • it is complex and time-consuming to have double access to a patient.
  • an object of the invention to provide an oxygenator device with which a patient can be subjected to treatment more easily and quickly, in particular in emergency situations. Furthermore, the handling of such devices is to be simplified with regard to the pumping function, preferably without the need for a separate blood inlet and outlet, as well as a connecting tube between the oxygenator and the pump.
  • This object is achieved with an oxygenator device of the type mentioned at the outset, in which the housing is connected to only a single cannula and the housing has an opening covered with a flexible and / or elastic pump membrane.
  • the single cannula preferably has an undivided cannula cross section, in particular at least at its free end facing a patient.
  • the one, single cannula that is connected to the patient for treatment has the advantage that only a single access to the patient's blood circulation has to be found, which is a relief especially in emergency situations.
  • the blood can then be transferred bidirectionally between the housing and the body of a patient through a single cannula.
  • the pump membrane has the further advantage that a possible pumping function to suck blood into the device through the single cannula and also expel it again through the single cannula is already integrated directly in the oxygenator device and the pumping function can be achieved by moving the membrane .
  • Is z. B. exerted a pressing force from the outside on the membrane, the inside of the membrane contacting blood inside the housing is shifted out of the housing in the direction of the single cannula, whereas by a pulling force on the pump membrane blood through the single cannula into the Housing is sucked in.
  • the forces for moving the pump membrane are exerted manually by a helping person, e.g. B. by a handle (z. B. a handle element) on the pump membrane.
  • the invention preferably provides for the movement to be carried out by means of an actuator which acts to move the pump membrane.
  • the invention can provide that the blood is moved bidirectionally along the outside of the hollow fibers during a reversing movement of the pump membrane.
  • a only unidirectional movement of the blood can be provided along the outside of the hollow fibers.
  • the pump membrane in the relaxed state ie when no external moving forces are exerted on it, forms an at least essentially flat surface which covers / spans the named opening of the housing of the device.
  • the inside of the pump membrane which is contacted by blood, can be close to the hollow fibers in the relaxed state, and in the borderline case contact them.
  • the entire device has a minimal volume.
  • Another preferred embodiment can provide that the pump membrane is bell-shaped, in particular in the relaxed state.
  • the bell-shaped pump membrane preferably in the relaxed state, delimits an inner volume free of hollow fibers and has an opening edge with which it is connected to the opening of the housing of the device.
  • This connection can be made by a detachable connection, but can also be cohesive, e.g. B. in that the flexible and / or elastic material of the pump membrane is glued or cast onto the edge of the opening of the housing.
  • the pump membrane is moved towards the hollow fibers in order to expel blood from the device.
  • the design is preferably such that the inner volume, which is free of hollow fibers and which is delimited by the bell-shaped pump membrane (particularly viewed up to the opening plane of the bell shape), is at least as large as the volume penetrated by hollow fibers in the interior of the housing, preferably at least as large as such as the total volume of the housing, cannula and the at least one cannula line section which connects the cannula to the housing.
  • This has the advantage that by moving the pump diaphragm the the blood passing through the hollow fibers is completely exchanged.
  • the volume bounded by the bell shape is preferably at least 1.5 times, more preferably at least 2 times greater than the volume in the interior of the housing penetrated by hollow fibers, preferably than the total volume of the housing, cannula and the at least one, preferably single cannula Line section.
  • a preferred embodiment can provide that an opening, via which the single cannula or a cannula line section, preferably a single cannula line section, opens into the housing, is opposite, in particular 180 degrees opposite, that opening of the housing that is covered by the pump membrane is.
  • the mouth area can preferably be designed to widen in cross section, in particular to widen in a funnel shape, in the direction of the hollow fiber packet. This leads to a deceleration of the blood and causes a more extensive distribution over the cross-section of the hollow fiber package against which the flow is flowing.
  • a preferred embodiment compared to manual handling can provide that the pump membrane is assigned an actuator with which the pump membrane can be moved.
  • Such an actuator can be designed as a linear actuator with a linearly moving pressure element which is preferably attached to the pump membrane from the outside. By fastening it can be achieved that the actuator can be used to exert pushing and pulling forces on the pump membrane.
  • the actuator itself, which moves the pressure element, can be driven pneumatically, hydraulically or electrically.
  • the pump membrane contacted by the blood on the inside is contacted on the outside by a fluid / fluid cushion, e.g. B. is contacted by gas / air or a liquid, with an actuator, z. B. a pump, a change in pressure of the fluid is effected in order to move the pump diaphragm.
  • a fluid / fluid cushion e.g. B. is contacted by gas / air or a liquid
  • an actuator z. B. a pump
  • the housing of the device in particular at least the part surrounding the hollow fibers, preferably the blood-filled space in the housing and / or the hollow fiber bundle, can preferably be cylindrical, in particular around a cylinder axis.
  • the base of the cylinder can be generated by any closed guide curve lying in one plane.
  • the base area can be designed without corners, but also, for example, polygonal, in particular be quadrangular.
  • a further preferred embodiment is given by a circular base area, which leads to a circular cylindrical design of the housing and / or hollow fiber bundle.
  • the cylinder axis is preferably oriented parallel to the direction of movement of the pressure element / pump membrane.
  • the cylinder axis around which the cylinder is formed is preferably parallel to a generatrix or a surface line of the cylinder of the housing and / or hollow fiber bundle.
  • the single cannula can furthermore preferably have a cannula line section which opens into the housing and extends parallel to the direction of movement of the pressure element and / or the cylinder axis of the hollow fiber bundle.
  • the preferably single cannula line section opening into the housing, the preferably cylindrical housing and the pressure element can be arranged around a common axis.
  • the device can preferably be rotationally symmetrical, more preferably rotationally symmetrical, with regard to the arrangement of the cannula line section, cylindrical housing wall and / or cylindrical hollow fiber bundle, pump membrane and pressure element.
  • a first preferred embodiment provides that the single cannula opens into the housing only via a single cannula line section which extends between the free end of the cannula and the housing, in particular which extends at least in the mouth area parallel to the cylinder axis of the housing and / or fiber bundle and / or the direction of movement of the pressure element.
  • the blood flows bidirectionally in the entire arrangement from the single cannula and the single cannula line section from the free cannula end (ie intended for connection to the patient's vascular system) to the housing, in particular reversing in the direction with the reversing movement of the pump membrane.
  • a bidirectional movement of the blood is then also present in the housing area through which the hollow fibers pass.
  • Another embodiment can provide that the single cannula branches into two cannula line sections in the direction of the housing, with one of the branched cannula line sections in front of the hollow fibers and the other branched cannula line section after the Hollow fibers open into the housing. The mouths of both cannula line sections mentioned are thus arranged around the hollow fiber bundle.
  • the cannula also has a third line section in which the two cannula line sections mentioned are combined in the direction of the free cannula end intended for connection to the patient's vascular system.
  • this third cannula line section there is always a movement of the blood that reverses with the reversing pumping movement, that is, a bidirectional movement.
  • the two aforementioned branched cannula line sections which extend between the third line section and the housing, there can preferably only be one unidirectional blood flow, in particular in different directions.
  • the flow direction of blood in the two cannula sections is unidirectional and opposite to each other.
  • the blood flows in one cannula section only in the suction phase of the pumping movement and in the other cannula section only in the ejection phase.
  • the blood preferably only flows unidirectionally in the housing area interspersed with hollow fibers, e.g. B. during the ejection movement in one direction from the pump membrane to the opposite mouth area of the cannula line section.
  • the invention can further provide that the oxygenator device comprises a device generating negative pressure, in particular a gas pump / vacuum pump, with which the gas pressure inside the hollow fibers can be set lower than the pressure in the blood, in particular during the phase of sucking in the Blood into the device.
  • a negative pressure is generated in the blood-filled area of the housing.
  • the lower pressure generated in the hollow fibers prevents gas in the form of bubbles from escaping from the hollow fibers into the blood.
  • the gas pressure is preferably reduced only during the intake phase. A greater gas exchange can thus be achieved during the ejection phase. Therefore, it is preferably provided that, if the hollow fiber packet is not flown through bidirectionally during pumping, the hollow fiber packet is traversed when the blood is expelled from the device, in particular one of the two cannula sections is used as a bypass in order to suck the blood past the hollow fiber packet when sucking in.
  • the device according to the invention can furthermore be set up to interrupt the gas flow through the hollow fibers during the suction phase, in particular by means of at least one valve in the gas supply that is controlled synchronously with the pumping movement. This already reduces the pressure in the hollow fibers during this phase.
  • Figure 1 shows a first embodiment of an oxygenator device 1 with a housing 2, which is at least partially penetrated by hollow fibers 3 of a hollow fiber package.
  • the housing has a wall 2a with a circular cylindrical cross-section and an axial extension in the direction of the axis 4.
  • the housing 2 has an opening 5a in the dashed line 5, which does not necessarily have to be open to the environment, but also one may be internal opening 5a, to which a bell-shaped pump membrane 6 is connected.
  • the pump membrane 6 thus covers the opening 5a.
  • the pump membrane 6 is also surrounded on the outside by a housing section 2a.
  • the housing 2 On the side opposite the pump membrane 6, the housing 2 has an area 7 which is designed to widen in the direction of the hollow fibers in the shape of a funnel in cross section, in which the only cannula 8 provided here opens into the housing 2 via a single cannula line.
  • the area 7 forms or surrounds an opening 7a via which the cannula 8 opens into the housing.
  • the cannula 8 here has at least one cannula which opens into the housing 2 Line section 8a, which extends linearly with an extension direction which is parallel, here collinear, to the axis 4.
  • a pressure element 9 acts on the pump membrane 6, in particular it is attached to the membrane 6.
  • the pressure element 9 can be moved back and forth in a reversing manner parallel to the axis 4, preferably collinear to the axis 4.
  • the bell-shaped pump membrane surrounds an inner volume 11 of the device which is free of hollow fibers and adjoins the volume 12 in the device which is penetrated by hollow fibers.
  • the volume 11 is preferably larger, in particular at least 1.5 times larger than the volume 12, in order to achieve a complete exchange of blood in the volume region 12 of the hollow fibers during pumping.
  • a pumping function now takes place by moving the pressure element 9 in a reversing manner, a movement to the left, based on the figure, causes the blood to be expelled from the device. Moving to the right draws blood into the device.
  • ejection and suction take place through the same single cannula 8, so that only one access to a patient's blood circulation is required. In the cannula 8, the blood thus flows bidirectionally reversing synchronously with the pumping movement of the pressure element 9.
  • Section A-A shows two different ways of arranging the hollow fibers.
  • the illustration on the left shows a stack with hollow fibers 3 which intersect at 90 degrees and which are stacked as mats.
  • the right-hand figure of the section shows a three-fold different crossing of the fibers 3.
  • the fibers 3 open out on one side into a gas inflow area 3a and on the other side in a gas outflow area 3b. These areas 3a, 3b are separated from the blood-carrying volume of the housing 2 by adhesive bonding / potting of the fibers 3 to one another and to the housing wall 2a, as is well known in the art in specialist circles.
  • the blood flow through the hollow fiber package around the outside of the fibers is preferably on the average perpendicular to the gas flow which passes through the fibers, with gas exchange being able to take place due to the semi-permeability of the hollow fiber wall.
  • the gas is sucked in with a negative pressure compared to the pressure present in the blood in the suction phase, e.g. B. by means of a vacuum pump 13 to prevent a bubble-shaped outgassing of the gas into the blood. Provision can be made for this negative pressure to be generated only in the intake phase.
  • FIG. 2 An alternative embodiment is shown in FIG. 2, in which, unlike in FIG. 1, the single cannula 8 branches off in the direction of the housing 2 into two line sections 8a and 8b. As a result, and with the switching valve 12 in the branching area, it is achieved that during the suction phase the blood is sucked into the housing via the line section 8b of the cannula 8, the blood flowing into the housing 2 between the hollow fiber package and the pump membrane, i.e. in the bypass to the Hollow fibers 3 of the hollow fiber package over.
  • the valve blocks the flow through the cannula line section 8b by external control or automatically, so that the blood is pushed back through the hollow fiber package and the cannula line section 8a.
  • the valve blocks the flow through the cannula line section 8b by external control or automatically, so that the blood is pushed back through the hollow fiber package and the cannula line section 8a.
  • the valve In the hollow fiber package, there is therefore only a unidirectional flow in the direction of the cannula line section 8a in the ejection phase.
  • the invention can also provide an embodiment (not shown) in which, in the suction phase, the blood is sucked into the housing through at least two cannula line sections of the at least twofold branched cannula, but is expelled through the hollow fiber package and only one cannula line section.
  • the suction can also take place through that section of the plurality of cannula line sections in which the blood flow leads through the hollow fiber packet in the ejection phase.
  • the blood can be pushed back into the bloodstream completely through the hollow fiber package and through only one of the cannula line sections.
  • the suction of the gas described in relation to FIG. 1 for generating negative pressure can in this case be omitted or can be less.

Landscapes

  • Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un dispositif d'oxygénateur (1) comprenant un boîtier (2) qui peut être rempli de sang et dans lequel des fibres creuses perméables aux substances (3) sont disposées, plus particulièrement sous la forme d'une pile ou bobine de tapis de fibres creuses, un gaz pouvant s'écouler à travers l'intérieur des fibres creuses et le sang pouvant s'écouler autour de l'extérieur des fibres creuses, le boîtier (2) étant relié à une seule canule (8), plus particulièrement dans lequel, pendant le fonctionnement du dispositif, le sang peut être transféré de manière bidirectionnelle entre le boîtier (2) et le corps d'un patient, et le boîtier (2) ayant une ouverture (5a) recouverte d'une membrane de pompe souple et/ou élastique (6) et, plus particulièrement par déplacement de ladite ouverture, le sang pouvant, pendant le fonctionnement, être déplacé dans au moins une direction, de préférence de manière bidirectionnelle le long des fibres creuses (3).
PCT/EP2020/081777 2019-11-20 2020-11-11 Dispositif d'oxygénateur WO2021099195A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102019131369.4 2019-11-20
DE102019131369.4A DE102019131369A1 (de) 2019-11-20 2019-11-20 Oxygenatorvorrichtung

Publications (1)

Publication Number Publication Date
WO2021099195A1 true WO2021099195A1 (fr) 2021-05-27

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ID=73698771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2020/081777 WO2021099195A1 (fr) 2019-11-20 2020-11-11 Dispositif d'oxygénateur

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DE (1) DE102019131369A1 (fr)
WO (1) WO2021099195A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897189A (en) * 1987-10-23 1990-01-30 Research Corporation Limited Blood purification apparatus
WO2005028002A1 (fr) * 2003-09-22 2005-03-31 Dudu Haimovich Systeme d'oxygenation du sang avec catheter a passage interne unique
WO2011085714A1 (fr) * 2010-01-13 2011-07-21 Oliver Marseille Agencement comportant une pompe à sang et un échangeur gazeux pour l'oxygénation de membrane extracorporelle

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2198759B1 (fr) * 1972-09-12 1976-06-04 Rhone Poulenc Ind
EP2217301A2 (fr) * 2007-10-12 2010-08-18 DEKA Products Limited Partnership Systèmes, dispositifs et procédés pour un traitement cardio-pulmonaire et des procédures cardio-pulmonaires
DE102016010398A1 (de) * 2016-06-10 2017-12-14 Hemovent Gmbh Gas-Austausch-Einheit, Verfahren zum Herstellen einer Gas-Austausch-Einheit und Set mit einer Gas-Austausch-Einheit und einer Befeuchtungs- und Wärmevorrichtung
DE102017000843A1 (de) * 2017-01-31 2018-08-02 Hemovent Gmbh Extrakorporale Blutpumpe, Herz-Lungen-Maschine, Verfahren zum Betreiben einer extrakorporalen Blutpumpe sowie Verfahren zum Betreiben einer Herz-Lungen-Maschine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897189A (en) * 1987-10-23 1990-01-30 Research Corporation Limited Blood purification apparatus
WO2005028002A1 (fr) * 2003-09-22 2005-03-31 Dudu Haimovich Systeme d'oxygenation du sang avec catheter a passage interne unique
WO2011085714A1 (fr) * 2010-01-13 2011-07-21 Oliver Marseille Agencement comportant une pompe à sang et un échangeur gazeux pour l'oxygénation de membrane extracorporelle

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