WO2021081643A1 - Seringue - Google Patents

Seringue Download PDF

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Publication number
WO2021081643A1
WO2021081643A1 PCT/CA2020/051448 CA2020051448W WO2021081643A1 WO 2021081643 A1 WO2021081643 A1 WO 2021081643A1 CA 2020051448 W CA2020051448 W CA 2020051448W WO 2021081643 A1 WO2021081643 A1 WO 2021081643A1
Authority
WO
WIPO (PCT)
Prior art keywords
plunger
protrusion
barrel
syringe
fluid
Prior art date
Application number
PCT/CA2020/051448
Other languages
English (en)
Inventor
Jack Finkelstein
Original Assignee
Liquimedlock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liquimedlock filed Critical Liquimedlock
Publication of WO2021081643A1 publication Critical patent/WO2021081643A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/025—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
    • G01F11/027—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons of the syringe type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3135—Syringe barrels characterised by constructional features of the proximal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback

Definitions

  • the present disclosure relates to syringes.
  • Syringes conventionally comprise a plunger moveable in a barrel and defining a chamber into which fluid can be drawn.
  • An accurate measurement of the fluid being drawn into the syringe or being expulsed from the syringe can be critical, especially when the syringe is used for measuring a dosage. This is particularly important in the medical sector, such as when administering drugs or other substances to patients, in which cases an incorrect dosage can be dangerous and sometimes even fatal.
  • a syringe which can generate a detectable signal on aspirating a fluid of a given volume into a chamber of the syringe, and/or when dispensing a fluid of a given volume out of the chamber.
  • the syringe of the present technology can measure accurate volumes of fluids, and can be used to verify a measure of the volume of fluid during aspiration and/or ejection according the measurement signal generated.
  • the measurement signal may be tactile, audible, or both.
  • a syringe comprising a plunger slidingly receivable in a barrel.
  • the plunger has an elongate plunger body with a longitudinal axis.
  • the elongate plunger body comprises an outer surface having a continuous form, and at least one plunger protrusion as a measurement indicator.
  • the at least one plunger protrusion has a plunger protrusion body which extends circumferentially along the outer surface by a plunger protrusion length, along a plunger protrusion length axis.
  • the plunger protrusion length axis is on a plane substantially transverse to the longitudinal axis of the plunger.
  • the elongate plunger body extends from the outer surface by a plunger protrusion height along a plunger protrusion height axis.
  • the plunger protrusion height axis is substantially transverse to the longitudinal axis of the plunger.
  • the plunger protrusion body further comprises a plunger protrusion distal end with an arcuate (rounded) form.
  • the barrel has an elongate barrel body with a longitudinal axis.
  • the elongate barrel body defines a channel for receiving the plunger.
  • the plunger defines a chamber for housing fluid, within the channel, when a first end of the plunger is housed in the barrel.
  • the elongate barrel body has a first open end arranged to receive fluid into the chamber and to expel fluid from the chamber; a second open end through which the plunger is slidingly moveable; and an inner wall having a barrel protrusion for engagement with the plunger protrusion when the plunger is moved relative to the barrel.
  • the barrel protrusion has a barrel protrusion body which extends circumferentially along the inner wall by a barrel protrusion length along a barrel protrusion length axis.
  • the barrel protrusion length axis is on a plane substantially transverse to the longitudinal axis of the barrel.
  • the barrel protrusion body extends from the inner wall by a barrel protrusion height along a barrel protrusion height axis.
  • the barrel protrusion height axis is substantially transverse to the longitudinal axis of the barrel.
  • the barrel protrusion body further comprises a barrel protrusion distal end with an arcuate (rounded) form.
  • the plunger protrusion and the barrel protrusion are sized to contact one another when the plunger is moved relative to the barrel through a force applied in a first direction, such that a continued applied force in the first direction causes the plunger protrusion to slide past the barrel protrusion and generates a detectable measurement signal.
  • a device for generating a detectable tactile or sound signal comprising a plunger slidingly receivable in a barrel.
  • the plunger has an elongate plunger body with a longitudinal axis.
  • the elongate body comprises an outer surface having a continuous form, and at least one plunger protrusion having a plunger protrusion body.
  • the plunger protrusion body extends circumferentially along the outer surface by a plunger protrusion length along a plunger protrusion length axis.
  • the plunger protrusion axis is on a plane substantially transverse to the longitudinal axis of the plunger.
  • the plunger protrusion body also extends from the outer surface by a plunger protrusion height along a plunger protrusion height axis.
  • the plunger protrusion height axis is substantially transverse to the longitudinal axis of the plunger.
  • the plunger protrusion body further comprises a plunger protrusion distal end with an arcuate (rounded) form.
  • the barrel has an elongate barrel body with a longitudinal axis, the elongate barrel body defining a channel for receiving the plunger.
  • the plunger defines a chamber for housing fluid, within the channel, when a first end of the plunger is housed in the barrel.
  • the elongate barrel body has a first open end arranged to receive fluid into the chamber and to expel fluid from the chamber; a second open end through which the barrel is slidingly moveable; and an inner wall having a barrel protrusion for engagement with the plunger protrusion when the plunger is moved relative to the barrel.
  • the barrel protrusion has a barrel protrusion body extending circumferentially along the inner wall by a barrel protrusion length along a barrel protrusion length axis.
  • the barrel protrusion length axis is on a plane substantially transverse to the longitudinal axis of the barrel.
  • the barrel protrusion body also extends from the inner wall by a barrel protrusion height along a barrel protrusion height axis.
  • the barrel protrusion height axis is substantially transverse to the longitudinal axis of the barrel.
  • the barrel protrusion body further comprises a barrel protrusion distal end with an arcuate (rounded) form.
  • the plunger protrusion and the barrel protrusion are sized to contact one another when the plunger is moved relative to the barrel through a force applied in a first direction, such that a continued applied force in the first direction causes the plunger protrusion to slide past the barrel protrusion generating a detectable measurement signal.
  • a syringe comprising a plunger slidingly receivable within a barrel to define a chamber for receiving a fluid, and a measurement signal mechanism.
  • the measurement signal mechanism comprises corresponding protrusions on the plunger and the barrel which are arranged to contact one another, and generate a tactile and/or audible signal when they are caused to slide past each other when the plunger is being moved into the barrel and out of the barrel.
  • the corresponding protrusions have respective contact faces which contact one another when the plunger is moved relative to the barrel, and wherein each of the respective contact faces are rounded.
  • the corresponding protrusions on the plunger and the barrel are both rounded.
  • a contact portion of the protrusions on the plunger and the barrel are rounded. This can reduce wear and tear, and also reduce the release of debris associated with wear which may contaminate the fluid in the chamber.
  • the measurement signal is one or both of a tactile signal and an audible signal.
  • one or both of the elongate plunger body and the elongate barrel body are cylindrical.
  • the elongate plunger body is solid. [0018] In certain embodiments any one or more of the preceding aspects, the elongate plunger body is hollow, and optionally wherein a fluid capacity of the syringe is more than about 1 ml.
  • the elongate plunger body is not of a ribbed-type, and optionally wherein a fluid capacity of the syringe is equal to or less than about 1 ml.
  • the elongate plunger body is of a ribbed-type, and optionally wherein a fluid capacity of the syringe is more than about 1 ml.
  • the plunger protrusion extends around the outer surface of the plunger in a continuous ring-like form.
  • plunger protrusion extends around the outer surface of the plunger in an interrupted segmented form.
  • the plunger protrusion is segmented, and comprises at least two segments extending around the outer surface of the plunger, the at least two segments being spaced from one another.
  • the plunger protrusion may be segmented into any number of segments other than the two segments, such three or four segments. The spacing of the segments from each other may be the same or different from one another.
  • the plunger protrusion length or a length of a segment of the plunger protrusion is less than a circumference of the outer surface of the plunger.
  • the plunger protrusion length or the length of a segment of the plunger protrusion is between about 1.2 mm to about 3.0 mm, about 1.3 mm, or about 2.44mm.
  • the plunger protrusion has a cross-sectional plunger protrusion profde taken across the plunger protrusion length which is arcuate.
  • the cross-sectional plunger protrusion profde may be circular or may have a circular portion.
  • the cross- sectional plunger protrusion profde has a symmetrical form.
  • the cross - sectional plunger protrusion profde is angular (e.g. square, rectangular, and triangular).
  • the plunger protrusion height is between about 0.14 mm and about 0.19 mm, about 0.185 mm, or about 0.15mm.
  • a width of the plunger protrusion is between about 0.4 mm and about 0.6 mm, and optionally about 0.5 mm.
  • a radius of curvature of the distal end of the plunger protrusion is between about 0.2 mm and about 0.4 mm, and optionally about 0.26 mm.
  • the elongate plunger body has a diameter which is bigger than the plunger protrusion height.
  • the ratio of the diameter of the elongate plunger body to the plunger protrusion height is between about 15:1 and 30:1, and about 22:1, or about 28:1.
  • the diameter of the elongate plunger body is about 4.15 mm, and the plunger protrusion height is about 0.185 mm. [0035] In certain embodiments of any one or more of the preceding aspects, the diameter of the elongate plunger body is about 4.15 mm, and the plunger protrusion height is about 0.15 mm.
  • the at least one plunger protrusion comprises a plurality of protrusions spaced from one another along the outer surface of the plunger.
  • the plurality of plunger protrusions are equally spaced from one another along the longitudinal axis of the plunger.
  • the plunger protrusions may be parallel to one another.
  • a spacing between the plurality of plunger protrusions corresponds to a given volume of fluid to be housed in the chamber.
  • the given volume of fluid is one or more of about 0.05 ml, 0.01 ml, about 0.1 ml, about 0.2 ml, about 0.5 ml, about 1 ml, about 1.5 ml, and about 2.0 ml.
  • one of the plunger protrusion and the barrel protrusion has a continuous circumferential form, and the other of the plunger protrusion and the barrel protrusion has a segmented circumferential form.
  • the barrel protrusion is proximate the second open end of the barrel.
  • the barrel protrusion is spaced from the first open end of the barrel according to a given fluid volume measurement.
  • the barrel protrusion has a cross-sectional barrel protrusion profile taken across the barrel protrusion length which is arcuate.
  • the cross-sectional barrel protrusion profile may be circular or may have a circular portion.
  • the cross- sectional barrel protrusion profile has a symmetrical form.
  • the cross- sectional barrel protrusion profile is angular (e.g. square, rectangular, and triangular).
  • the barrel protrusion height is between about 0.02 mm and about 0.19 mm, or about 0.075 mm or about 0.15 mm.
  • the barrel protrusion has a width of between about 0.4 mm and about 0.8 mm, and optionally about 0.61 mm.
  • a radius of curvature of the arcuate form of the barrel protrusion is between about 0.4 mm and about 0.8 mm, and optionally about 0.62 mm.
  • the first open end of the barrel is configured to attach a needle to the barrel, and optionally wherein the first open end is configured as a luer lock.
  • the syringe further comprises at least one marking on an outer wall of the elongate barrel body, the at least one marking corresponding to a given volume of fluid.
  • the syringe further comprises a plurality of the markings on the outer wall of the elongate barrel body, a spacing between the plurality of the markings correspond to a given volume of fluid.
  • the spacing between the markings correspond to the spacing between the plunger protrusions.
  • an overlap in the barrel protrusion height and the plunger protrusion height when the barrel protrusion and the plunger protrusion are aligned comprises about 20 % and about 60%, and optionally about 30%, of the distance between the plunger body and the barrel body in the chamber.
  • the plunger protrusion and the barrel protrusion are made of different materials having different compression properties.
  • the plunger body comprises the first end and a second end.
  • the first end is arranged to define the chamber of the barrel when the plunger is housed in the barrel, and the second end is arranged to be disposed outside of the second open end of the barrel.
  • the plunger comprises a stopper protrusion on the first end, the stopper protrusion being arranged to abut a shoulder formed in the barrel body proximate the first open end.
  • the plunger comprises a single plunger protrusion spaced from the first end of the plunger along the longitudinal axis of the plunger.
  • the single plunger protrusion is spaced from the stopper protrusion at the first end by a spacing; the spacing corresponding to a given volume of fluid to be housed in the chamber.
  • the fluid capacity of the syringe is about 1 ml and the spacing corresponds to about 0.1 ml, about 0.2 ml, about 0.3 ml, about 0.4 ml, about 0.6 ml, about 0.7 ml, about 0.8 ml, or about 0.9 ml.
  • the spacing corresponds to about 0.3ml or 0.5 ml of given volume of fluid to be housed in the chamber.
  • one or both of the plunger protrusions and barrel protrusions may have a different symmetry to generate a different signal when aspirating fluid compared to when ejecting fluid.
  • the barrel protrusion is on an inner surface of the barrel and the plunger protrusion is on an outer surface of the plunger.
  • the barrel protrusion may comprise a stopper ring at a top end (second end) of the barrel.
  • each protrusion there are a number of plunger protrusions positioned along a length of the plunger in columns, with a position of each protrusion corresponding with a respective volume of fluid, e.g. 0.1 ml, 0.2 ml, 0.3 ml.
  • Each one of the plunger protrusions may be the same or different in size, shape and configuration. In certain embodiments in which one or more of the plunger protrusions are different from one another, this may generate a different measurement signal indicating different measurements to the user.
  • one side of the plunger protrusion has a different profile than the other side of the plunger protrusion, which may generate a different measurement signal when aspirating the fluid compared to when ejecting the fluid.
  • the plunger protrusion(s) and the barrel protrusions may be of any suitable size or shape for generating a desired measurement signal.
  • a magnitude of the generated measurement signal (whether tactile or audible) can be adjusted by adapting one or more of: individual or relative protrusion height, individual or relative protrusion width, individual or relative protrusion length, and surface area of contact of the protrusions. Any possible damping effect of the fluid to be aspirated and dispensed on the magnitude of the generated signal can also be taken into account.
  • a syringe comprising a plunger slidingly receivable in a barrel.
  • the plunger has an elongate plunger body with a longitudinal axis.
  • the elongate plunger body comprises an outer surface having a continuous form, and at least one plunger protrusion.
  • the at least one plunger protrusion has a plunger protrusion body which extends circumferentially along the outer surface by a plunger protrusion length, along a plunger protrusion length axis.
  • the plunger protrusion length axis is on a plane substantially transverse to the longitudinal axis of the plunger.
  • the elongate plunger body extends from the outer surface by a plunger protrusion height along a plunger protrusion height axis.
  • the plunger protrusion height axis is substantially transverse to the longitudinal axis of the plunger.
  • the barrel has an elongate barrel body with a longitudinal axis.
  • the elongate barrel body defines a channel for receiving the plunger.
  • the plunger defines a chamber for housing fluid, within the channel, when a first end of the plunger is housed in the barrel.
  • the elongate barrel body has a first open end arranged to receive fluid into the chamber and to expel fluid from the chamber; a second open end through which the plunger is slidingly moveable; and an inner wall having a barrel protrusion for engagement with the plunger protrusion when the plunger is moved relative to the barrel.
  • the barrel protrusion has a barrel protrusion body which extends circumferentially along the inner wall by a barrel protrusion length along a barrel protrusion length axis.
  • the barrel protrusion length axis is on a plane substantially transverse to the longitudinal axis of the barrel.
  • the barrel protrusion body extends from the inner wall by a barrel protrusion height along a barrel protrusion height axis.
  • the barrel protrusion height axis is substantially transverse to the longitudinal axis of the barrel.
  • the plunger protrusion and the barrel protrusion are sized and shaped to contact one another but not move past one another when the plunger is moved relative to the barrel through a force applied in a first direction.
  • the plunger protrusion is spaced from the first end along the longitudinal axis of the plunger to define a volume of less than 1.0 ml of liquid to be housed in the chamber.
  • the plunger further comprises a stopper protrusion on the first end of the elongate body of the plunger.
  • the stopper protrusion is configured to abut a shoulder formed in the barrel body proximate the first open end of the barrel when the plunger is in a fully housed position in the barrel.
  • a cross-sectional plunger protrusion profde of the plunger protrusion taken across the plunger protrusion length is angular and has an asymmetrical form.
  • a cross-sectional barrel protrusion profde of the barrel protrusion taken across the barrel protrusion length is arcuate and has a symmetrical form.
  • the volume of liquid to be housed in the chamber is any one of 0.1 ml, 0.2 ml, 0.3 ml, 0.4 ml, 0.5 ml, 0.6 ml, 0.7 ml, 0.8 ml, 0.9 ml or 1.0 ml.
  • the plunger protrusion and the barrel protrusion generate a detectable measurement signal indicating a measurement of 0.3ml. In yet other embodiments, the plunger protrusion and the barrel protrusion generate a detectable measurement signal indicating a measurement of 0.5 ml.
  • a syringe comprising a plunger slidingly receivable within a barrel to define a chamber for receiving a fluid.
  • the syringe further comprises a measurement signal mechanism comprising a single plunger protrusion and a single barrel protrusion which are arranged to contact one another when the plunger is being moved out of the barrel.
  • a relative position of the single plunger protrusion and the single barrel protrusion is configured to indicate a given volume of fluid in the chamber.
  • the plunger protrusion and the barrel protrusion are sized and shaped to contact one another but not move past one another when the plunger is moved relative to the barrel through a force applied in a first direction.
  • a syringe comprising a plunger slidingly receivable within a barrel to define a chamber for receiving fluid.
  • the plunger has a plunger body and the barrel has a barrel body.
  • the plunger comprises a first plunger protrusion extending outwardly from an outer surface of the plunger body and the barrel comprises a barrel protrusion extending inwardly from an inner surface of the barrel body.
  • the plunger protrusion and the barrel protrusion are configured to contact one another when the plunger is being moved relative to the barrel.
  • a relative position of the plunger protrusion and the barrel protrusion is configured to indicate a given volume of fluid in the chamber.
  • the plunger protrusion and the barrel protrusion are sized and shaped to contact one another and to provide a resistance to moving the plunger relative to the barrel when a force is applied to one or both of the plunger and the barrel. This can be considered a safety stop in certain embodiments.
  • the plunger comprises a second plunger protrusion, the second plunger protrusion being spaced from the first plunger protrusion along the plunger body.
  • the first protrusion is positioned proximate a first end of the plunger, the first end of the plunger being received in the barrel when the plunger and barrel are assembled.
  • the second protrusion may be positioned a second end of the plunger and prevent a resistance to a separation of the plunger from the barrel.
  • kits comprising: one or more syringes as described herein and a container of fluid to be dispensed using the syringe.
  • the kit further comprises a packaging for housing the one or more syringes and the container of fluid.
  • the fluid to be dispensed is a medication.
  • the fluid to be dispensed is a cannabis product.
  • the kit further comprises instructions for use of the kit.
  • the syringe in the kit is able to dispense 0.3ml of fluid or 0.5 ml of fluid.
  • a material of the barrel need not be transparent or translucent, enabling the use of the syringe with light- sensitive fluids.
  • engagement of the plunger protrusion and the barrel protrusion results in a hard stop, indicating a precise single dose measurement and decreasing the risk of potential overdose in a user.
  • hard stop is meant that the plunger and the barrel cannot be readily moved relative to each other by an adult user. In other words, a force required to move the plunger and barrel protrusions past each other is more than a typical force used for operating a syringe.
  • the term “about” in the context of a given value or range refers to a value or range that is within 20%, preferably within 10%, and more preferably within 5% of the given value or range.
  • the term “and/or” is to be taken as specific disclosure of each of the two specified features or components with or without the other.
  • a and/or B is to be taken as specific disclosure of each of (i) A, (ii) B and (iii) A and B, just as if each is set out individually herein.
  • fluid encompasses substances tending to flow or conform to the outline of its container.
  • fluid includes liquids, gases, and gels, or any substance which can be caused to flow by application of pressure.
  • FIG. 1 illustrates a perspective view of a syringe comprising a plunger and a barrel, according to certain embodiments of the present technology.
  • FIG. 2 illustrates a perspective view of the syringe of FIG. 1, with the plunger removed from the barrel, according to certain embodiments of the present technology.
  • FIG. 3 illustrates a cross-sectional view of the barrel of FIG. 1, according to certain embodiments of the present technology.
  • FIG. 4 illustrates a side view of the plunger of FIG. 1, according to certain embodiments of the present technology.
  • FIG. 5 illustrates a cross-sectional view through the line A-A’ of the plunger of FIG. 1 4, according to certain embodiments of the present technology.
  • FIG. 6 illustrates a cross-sectional view through the line A-A' of the syringe of FIG. 1, according to certain embodiments of the present technology.
  • FIG. 7 illustrates an enlarged portion of a stopper protrusion on the plunger of FIG. 5, according to certain embodiments of the present technology.
  • FIG. 8 illustrates an enlarged portion of respective second ends of the plunger and the barrel of FIG. 1, according to certain embodiments of the present technology.
  • FIG. 9 illustrates cross-sectional views, through the lines B-B' and C-C of enlarged portions of the plunger and the barrel of FIG. 8, according to certain embodiments of the present technology.
  • FIG. 10A illustrates an enlarged view of portions of the plunger and the barrel of FIG. 9 when assembled as a syringe, according to certain embodiments of the present technology.
  • FIG. 10B illustrates a further enlarged view of the cross-sectional view of the plunger and the barrel of FIG. 10A.
  • FIG. 11 illustrates an enlarged portion of the cross-sectional view of the syringe of FIG. 6, according to certain embodiments of the present technology.
  • FIG. 12 illustrates an enlarged view of portions of the cross-sectional of view of the plunger and the barrel of FIG. 10B with the plunger protrusion and barrel protrusion in a A) pre-contact phase, B) contact phase, and C) post-contact phase.
  • FIG. 13 illustrates a cross-sectional view through the line D-D' of the plunger of FIG. 4, according to certain embodiments of the present technology.
  • FIG. 14A illustrates a perspective view of a syringe comprising a plunger and a barrel and having a 0.5 mL capacity, according to certain embodiments of the present technology.
  • FIG.14B illustrates a cross-sectional view through the line E-E’ of the plunger of FIG. 14A, according to certain embodiments of the present technology.
  • FIG. 15A illustrates a cross-sectional view through the line F-F' of the syringe of FIG. 14A, according to certain embodiments of the present technology.
  • FIG. 15B illustrates an enlarged view of the cross-sectional view of the plunger and the barrel of FIG. 15A according to certain embodiments of the present technology.
  • FIG. 16A illustrates a perspective view of a syringe comprising a plunger and a barrel and having a 0.3 mL capacity, according to certain embodiments of the present technology, with a single plunger protrusion corresponding to a 0.3 ml measurement of fluid.
  • FIG.16B illustrates a cross-sectional view through the line G-G’ of the plunger of FIG. 16A, according to certain embodiments of the present technology.
  • a syringe with a measurement signal mechanism which is arranged to generate a tactile and/or audible signal corresponding to predetermine measurement volumes.
  • the measurement signal mechanism comprises corresponding protrusions on a plunger and a barrel of the syringe with respective contact faces which contact one another when the plunger is moved relative to the barrel.
  • the syringe may be used for any application such as measurement of liquids such as medications.
  • a syringe 10 comprising a plunger 12 and a barrel 14.
  • the plunger 12 has a plunger body 16 which is elongate and having a longitudinal axis 18.
  • the plunger body 16 comprises an outer surface 20 with a continuous form 22 and a plurality of plunger protrusions 24 as a measurement indicator.
  • the measurement indicator in certain embodiments, is not a visual indicator but can be an audible signal or a tactile signal, as will be described further below. In certain other embodiments, there is provided a single plunger protrusion 24.
  • the barrel 14 has a barrel body 38 which is elongate and having a longitudinal axis 40.
  • the barrel body 38 defines a channel 41 for receiving the plunger 12, best seen in FIGS 2, 3 and 8).
  • the plunger is received in the barrel, at least one end of the plunger 12 is housed in the channel of the barrel 14, and defines a chamber 42 (best seen in FIGS. 14A, 15 A and 16A) configured to receive and house fluid dispensable from the barrel 14.
  • a maximum volume of fluid which the chamber 42 can house is referred to as a fluid capacity of the syringe 10.
  • the fluid capacity of the syringe 10 may be any volume appropriate to a given use such as one or more of about 0.3 ml, 0.5 ml, 1 ml, 2 ml, 3 ml, 5 ml, 10 ml, or more.
  • the barrel 14 comprises a plurality of markings 74 on an outer wall 75 of the barrel body 38.
  • a spacing 76 between the plurality of the markings 74 corresponds to a given volume of fluid.
  • the plurality of markings 74 are formed on an inner wall 48 of the barrel body 38, or are formed in the barrel body 38.
  • the plurality of the markings 74 on the outer wall 75 of barrel body 38 have different intensities.
  • the maximum volume of fluid to be housed in chamber 42 may have a marking 74 which is of higher intensity than the markings 74 which correspond to lower volumes of fluid.
  • the barrel 14 comprises a single marking 74.
  • the barrel 14 may be opaque or semi-opaque (i.e. not transparent or translucent), thus enabling the use of the syringe 10 with light-sensitive fluids. As such, in some embodiments, the barrel 14 may omit one or more of the markings 74 on the outer wall 75 of the barrel body 38.
  • the barrel 14 further comprises a first open end 44 arranged to receive the fluid into the chamber 42 and to expel the fluid from the chamber 42.
  • the first open end 44 is configured to attach a needle (not shown) or other attachment to the barrel 14.
  • the first open end 44 is configured as a luer lock.
  • the barrel 14 also comprises a second open end 46 through which the plunger 12 is slidingly moveable to provide the force necessary to aspirate and/or dispense the fluid from the chamber 42.
  • the second open end 46 has a flared portion 47 such that a diameter 51 at the second open end 46 is wider than a diameter 55 of the chamber 42.
  • a lip 49 is provided at an end of the flared portion 47 for ease of manipulation. The lip 49 can be sized and shaped to allow a user of the syringe to rest their fingers thereon to hold the barrel 14 in a stable position while applying force to slidingly move the plunger into or out of the chamber 42.
  • An inner wall 48 of the barrel 14 has a barrel protrusion 50 for engagement with at least one the plunger protrusion 24 when the plunger 12 is received in the barrel 14 and moves relative to the barrel 14.
  • the barrel protrusion 50 is proximate the second open end 46 of the barrel 14, and is positioned between the chamber 42 and the flared portion 47.
  • the barrel protrusion 50 may be spaced from the first open end 44 of the barrel 14 according to a given fluid volume measurement.
  • the given fluid volume measurement defined by the space between the barrel protrusion 50 and the first open end 44 of the barrel 14 may be about 0.3 ml. It will be understood that the given fluid volume measurement defined by the space between the barrel protrusion 50 and the first open end 44 of the barrel 14 may be of any given volume of the total fluid capacity of the syringe 10.
  • the plurality of protrusions 24 are equally spaced from one another along the longitudinal axis 18 of the plunger 12 by a spacing 69 therebetween, the spacing 69 corresponding to a given volume of fluid.
  • the given volume of fluid defined by the spacing 69 between the plurality of plunger protrusions 24 may be of any given volume of the fluid capacity of the syringe 10.
  • the given volume of fluid defined by the spacing 69 between the plurality of plunger protrusions 24 is one or more of about 0.05 ml, 0.01 ml, about 0.1 ml, about 0.2 ml, about 0.5 ml, about 1 ml, about 1.5 ml, about 2.0 ml, about 5.0 ml, or more.
  • the number of protrusions 24 and the spacing 69 between the protrusions 24 are appropriate to the fluid capacity of the syringe 10.
  • the syringe 10 has a fluid capacity of 1 ml, and has ten plunger protrusions 24, with each spacing 69 between the plunger protrusions 24 corresponding to a 0.1 ml measurement of fluid. There may be more or less than the ten plunger protrusions 24, with each spacing 69 being more or less than the 0.1 ml.
  • the syringe 10 has a fluid capacity of 50 ml, and has five plunger protrusions 24 with each spacing 69 corresponding to 10 ml.
  • one or more of the spacings 69 between the plurality of plunger protrusions 24 may be different from one another.
  • the syringe 10 has a fluid capacity of 1.0 ml and has three plunger protrusions 24, with the spacings 69 between the plunger protrusions 24 corresponding to a 0.1, 0.5, and 1.0 ml measurement of fluid, respectively.
  • the spacing 76 between the markings 74 on the outer wall 75 of the barrel body 38 correspond to the spacing 69 between the plurality of plunger protrusions 24 (example FIGS. 1 and 2).
  • the plunger body 16 as seen in FIGS 1, 2, 4, 5 and 7, comprises a first end 78 and a second end 80.
  • the first end 78 of the plunger body 16 defines a wall of the chamber 42 of the barrel 14 when the plunger 12 is housed in the barrel 14.
  • the second end 80 is arranged to be disposed outside of the second open end 46 of the barrel 14 (as seen in FIGS. 1 and 6).
  • the second end 80 in certain embodiments, has a flared portion 81 such that a diameter 71 at the second end 80 is wider than a diameter 68 of the plunger body 16 (best seen on FIG. 5).
  • the plunger 12 further comprises a stopper protrusion 82 on the first end 78 of the plunger body 16.
  • the stopper protrusion 82 is arranged to abut a shoulder 84 formed in the barrel body 38 proximate the first open end 44 of the barrel 14 when the plunger 12 is fully received into the chamber 42 of the barrel 14.
  • the stopper protrusion 82 is also arranged to engage the barrel protrusion 50 proximate the second open end 46 of the barrel 14, when the plunger 12 is moved out of the barrel 14 and fluid is aspirated into the syringe 10.
  • engagement of the stopper protrusion 82 and the barrel protrusion 50 generates a measurement signal, signaling to the user that the maximum fluid capacity of the syringe 10 has been reached.
  • a single plunger protrusion 24 instead of a plurality of plunger protrusions 24 (see for example FIG. 14A&B and FIG.16A&B).
  • the single plunger protrusion 24 is spaced from the stopper protrusion 82 along the longitudinal axis 18 of the plunger 12 by a spacing 69 therebetween.
  • the spacing 69 corresponds to a given volume of fluid appropriate to the fluid capacity of the syringe 10.
  • a position of the plunger protrusion 24 along the elongate body of the plunger will determine a position of the first end 78 of the plunger 12 relative to the first end of the barrel 14. This in turn, determines a size of the chamber 42, and hence a volume of the fluid houseable in the chamber.
  • a position of the plunger protrusion 24 corresponds to a 0.5ml and 0.3 ml measurement of fluid respectively.
  • the plunger protrusion 24 position may correspond to any other volume of fluid, such as but not limited to 0.1, 0.2, 0.4 ml, 0.6 ml, 0.7 ml, 0.8 ml, 0.9 ml or 1.0 ml volume of fluid.
  • spacing 69 may correspond to a volume of about 0.05 ml, about 0.1 ml, about 0.2 ml, about 0.3 ml, about 0.4 ml, about 0.5 ml, about 0.6 ml, about 0.7 ml, about 0.8 ml, or about 0.9 ml. It will be appreciated by those skilled in the art that the given volume of fluid defined by spacing 69 in these embodiments will depend in part on the distance between the plunger protrusion 24 and the stopper protrusions 82 along the longitudinal axis 18 of the plunger 12.
  • the distance between the plunger protrusion 24 and the stopper protrusions 82 of the plunger 12 may be between about 6.03mm to about 54.27 mm in a syringe 10 with a fluid capacity of 1.0 ml.
  • spacing 69 corresponds to a fluid capacity of 0.5 ml and the distance between the plunger protrusion 24 and the stopper protrusions 82 of the plunger 12 is about 39.80 mm.
  • spacing 69 corresponds to a fluid capacity of 0.3 ml and the distance between the plunger protrusion 24 and the stopper protrusions 82 of the plunger 12 is about 51.82 mm.
  • the plunger body 16 is cylindrical and of a solid configuration. In other words, it is not hollow. In other embodiments, particularly when the fluid capacity of the syringe 10 is larger than 5 ml, and for the purposes of reducing a weight of the syringe or for minimizing manufacturing costs, the plunger body 16 may be hollow (see for example, FIGS. 9 and 10 in which the plunger body 16 is cylindrical and hollow).
  • the plunger body 16 may be of any shape and configuration which allows for the plunger 12 to be slidingly receivable in the barrel 14, and which provides sufficient rigidity to the plunger body 16 to avoid deformation such as bending or crumpling.
  • the plunger body 16 may be of a ribbed-type having a cross-sectional profile in the shape of a cross. The configuration of the plunger body 16 may be selected based on the fluid capacity of the syringe 10.
  • the ribbed-configuration may be used when the fluid capacity of the syringe 10 is more than about 1ml or about 5 ml, and the plunger body 16 may have a solid configuration when the syringe 10 has a fluid capacity that is equal to or less than about 1 ml.
  • the plunger protrusion 24 extends circumferentially along the outer surface 20 of the plunger 12 and comprises a plunger protrusion body 26 having a plunger protrusion outer surface 27. Portion(s) of the outer surface 27 comprises the contact face for contacting the barrel protrusion 50 during relative movement of the plunger 12 and the barrel 14.
  • the plunger protrusion body 26 has a plunger protrusion length 28, a plunger protrusion height 32, and a plunger protrusion width 66.
  • the plunger protrusion body 26 has a plunger protrusion distal end 36 (also referred to as “profile” or “cross-sectional profile”) with an arcuate form having a radius of curvature.
  • the plunger protrusion length 28, the plunger protrusion height 32, the plunger protrusion width 66, and the radius of curvature of the arcuate form of the plunger protrusion distal end 36 are all factors affecting a magnitude of the generated measurement signal (e.g. extent of vibration or loudness of sound signal) and may be chosen according to the magnitude of the measurement signal desired in a given use of the syringe 10. In general, keeping all other parameters constant, increasing each of the plunger protrusion length 28, the plunger protrusion height 32, the plunger protrusion width 66 can be expected to produce a greater magnitude of the measurement signal.
  • the shape and form of portion(s) of the outer surface 27 comprising the contact face for contacting the barrel protrusion 50, and the cross-sectional plunger protrusion profde 64 may additionally contribute to a magnitude of the measurement signal generated and may be chosen according to a magnitude of the measurement signal desired in a given use of the syringe 10.
  • the plunger protrusion profde 64 is angular and asymmetrical, and is arranged to abut sharply against the barrel protrusion 50 when the plunger 12 is moved out of the barrel 14 to generate a measurement signal equivalent to a hard-stop. This indicates to the user that the maximum volume of the fluid capacity of the syringe 10 has been reached and prevents the user from withdrawing additional fluid into the syringe 10.
  • plunger protrusion length 28 it is meant a long dimension of the protrusion along the plunger protrusion length axis 30 extending circumferentially along the outer surface 20 of the plunger 12.
  • the plunger protrusion length 28 is less than a circumference of the outer surface 20 of the plunger 12. In other words, the plunger protrusion body 26 does not extend all the way around the outer surface 20 of the plunger 12. In other embodiments, as seen in FIGS.
  • the plunger protrusion body 26 comprises two segments extending circumferentially around the outer surface 20 of the plunger 12 on the same plane (which is substantially transverse to the longitudinal axis 18) by a segment length 29 and are equally spaced apart from one another.
  • the plurality of plunger protrusion segments on the same plane may have unequal spacings.
  • the plunger protrusion body 26 may comprise a single segment.
  • the plunger protrusion 26 is segmented and comprises three segments extending around the outer surface 20 of the pi unger 12, the three segments being spaced from one another.
  • the plunger protrusion 26 may be segmented into any number of segments other than the three segments, such as two, three or four segments. The spacing of the segments from each other may be the same or different from one another. When there are a plurality of plunger protrusion segments, they may be provided on the same plane which is substantially transverse to the longitudinal axis 18, or on different planes.
  • each plunger protrusion comprises two segments and the plurality of plunger protrusions 24 form two columns with each plunger protrusion 24 being aligned one beneath the other, in parallel form, between the first end 78 and second end 80 of the plunger 12.
  • the plurality of plunger protrusions 24 may be spaced from one another along the longitudinal axis 18 in a staggered configuration such that adjacent plunger protrusions 24 are not aligned one beneath the other.
  • the plunger protrusion length 28 may be between about 1.2 mm to about 3.0 mm, between about 1.2 mm to about 2.8, between about 1.2 mm to about 2.6 mm, between about 1.2 mm to about 2.4 mm, between about 1.2 mm to about 2.0 mm, between about 1.2 mm to about 1.8 mm, between about 1.2 mm to about 1.6 mm, between about 1.2 mm to about 1.4 mm, between about 1.4 mm to about 3.0 mm, between about 1.4 mm to about 2.8 mm, between about 1.4 mm to about 2.6 mm, between about 1.4 mm to about 2.4 mm, between about 1.4 mm to about 2.2, between about 1.4 mm to about 2.0, between about 1.4 mm to about 1.8, between about 1.4 mm to about 1.6, between about 1.6 mm to about 3.0 mm, between about 1.6 mm to about 2.8 mm, between about 1.6 mm to about 2.6 mm, between about 1.6 mm to about 3.
  • the plunger protrusion length 28 is about 1.3 mm. In other embodiments, the plunger protrusion length 28 is about 2.44 mm. In yet other embodiments, the plunger protrusion 24 may extend around the outer surface 20 of the plunger 12 in a continuous ring-like form such that the plunger protrusion length 28 is equal to the circumference of the outer surface 20 of the plunger 12.
  • the plunger protrusion height 32 is between about 0.140 mm and about 0.190 mm, between about 0.140 mm and about 0.185 mm, between about 0.140 mm and about 0.180 mm, between about 0.140 mm and about 0.175 mm, between about 0.140 mm and about 0.170 mm, between about 0.140 mm and about 0.165 mm, between about 0.140 mm and about 0.160 mm, between about 0.140 mm and about 0.155 mm, between about 0.140 mm and about 0.150 mm, between about 0.140 mm and about 0.145 mm, between about 0.145 mm and about 0.190 mm, between about 0.145 mm and about 0.185 mm, between about 0.145 mm and about 0.180 mm, between about 0.145 mm and about 0.175 mm, between about 0.145 mm and about 0.170 mm, between about 0.145 mm and about 0.165 mm, between about 0.145 mm and about 0.160 mm, between about 0.145 mm and about 0.155 mm
  • the diameter 68 of the plunger body 16 is greater than the plunger protrusion height 32 (best seen in FIG.11).
  • a ratio of the plunger body diameter 68 to the plunger protrusion height 32 may be between about 15:1 and 25:1, between about 15:1 and 20:1, between about 20:1 and 25:1. In other embodiments, the ratio of the plunger body diameter 68 to the plunger protrusion height 32 may be between about 25:1 and 30:1. In the embodiment of FIG.
  • the plunger body diameter 68 is about 4.15 mm, and the plunger protrusion height 32 is about 0.185 mm; the ratio of the diameter of the plunger body 68 to the plunger protrusion height 32 being about 22:1.
  • the plunger body diameter 68 is about 4.15 mm, and the plunger protrusion height 32 is about 0.15 mm; the ratio of the diameter of the plunger body 68 to the plunger protrusion height 32 being about 28: 1.
  • the plunger protrusion 24 and the barrel protrusion 50 have a cross-sectional plunger protrusion profde 64 and a cross-sectional barrel protrusion profde 70, taken across the plunger protrusion length 28 and the barrel protrusion length 54 respectively, which are arcuate.
  • the cross- sectional plunger protrusion profile 64 and the cross-sectional barrel protrusion profile 70 are circular (e.g. a semi-circle), and certain portions which are not arcuate or circular or which have different radiuses of curvature.
  • the cross-sectional plunger protrusion profde 64 and cross-sectional barrel protrusion profde 70 may have certain portions which are arcuate or circular.
  • the cross-sectional plunger protrusion profde 64 may be angular (e.g. square, rectangular, and triangular).
  • the cross-sectional plunger protrusion profde 64 and the cross-sectional barrel protrusion profde 70 have a symmetrical form.
  • this symmetrical configuration can generate similar measurement signals both on aspiration of the fluid into the syringe 10, and on ejection of the fluid from the syringe 10.
  • the configuration of the cross-sectional plunger protrusion profde 64 may be asymmetric in order to generate measurement signals which are different on aspiration compared to ejection.
  • the cross-sectional plunger protrusion profde 64 as best seen in FIG. 15B, is angular and has an asymmetric form. Such profiles may be useful for preventing further movement of the plunger 12 relative to the barrel 14, i.e. providing a hard stop.
  • the plunger protrusion width 66 is between about 0.40 mm and about 0.60 mm, between about 0.40mm and about 0.55 mm, between about 0.40 mm and about 0.50 mm, between about 0.45 mm and about 0.60 mm, between about 0.45 mm and about 0.55 mm, between about 0.45 mm and about 0.50 mm, between about 0.50 mm and about 0.60 mm, between about 0.50 mm and about 0.55 mm, or between about 0.55 mm and about 0.60 mm.
  • the plunger protrusion width 66 is about 0.50 mm.
  • the radius of curvature of the arcuate form of the distal end 36 of the plunger protrusion is between about 0.20 mm and about 0.40 mm, between about 0.20 mm and about 0.35 mm, between about 0.20 mm and about 0.30 mm, between about 0.20 mm and about 0.25 mm, between about 0.25 mm and about 0.40 mm, between about 0.25 mm and about 0.35 mm, between about 0.25 mm and about 0.30 mm, between about 0.30 mm and about 0.40 mm, between about 0.30 mm and about 0.35 mm, In the embodiment of FIG. 11, the radius of curvature of the distal end 62 is about 0.26 mm.
  • the barrel protrusion 50 comprises a barrel protrusion body 52 having a barrel protrusion outer surface 53. Portion(s) of the outer surface 53 comprise the contact face for contacting the plunger protrusion 24 during aspiration and ejection of fluid from the syringe 10.
  • the barrel protrusion body 52 also has a barrel protrusion length 54, a barrel protrusion height 58, and a barrel protrusion width 72.
  • the barrel protrusion body 52 has a barrel protrusion distal end 62 having an arcuate form with a given radius of curvature.
  • the barrel protrusion length 54, The barrel protrusion height 58, the barrel protrusion width 72, and the radius of curvature of the arcuate form of the plunger protrusion distal end 62 are all factors in a magnitude of the generated measurement signal (e.g. extent of vibration or loudness) and may be chosen according to the magnitude of the measurement signal desired in a given use of the present technology. In general, keeping all other parameters constant, increasing each of the barrel protrusion length
  • the barrel protrusion height 58, and the barrel protrusion width 72 can be expected to produce a greater magnitude of the measurement signal.
  • portion(s) of the outer surface 53 comprising the contact face for contacting the plunger protrusion 24, and the cross-sectional barrel protrusion profile 70 may additionally contribute to a magnitude of the measurement signal generated and may be chosen according to a magnitude of the measurement signal desired in a given use of the syringe 10.
  • portion(s) of the outer surface 53 comprising the contact face for contacting the plunger protrusion 24, and the cross-sectional barrel protrusion profile 70 may be chosen such as to create a hard stop.
  • the barrel protrusion body 52 extends circumferentially along the inner wall 48 of the barrel 14 by a barrel protrusion length 54 along a barrel protrusion length axis 56, the barrel protrusion length axis 56 being on a plane substantially transverse to the longitudinal axis 40 of the barrel 14.
  • the barrel protrusion 50 extends around the inner wall 48 in a continuous ring- like form such that the barrel protrusion length 54 is substantially the same as the circumference of the inner wall 48 of the barrel 14.
  • the continuous ring-like form of the barrel protrusion 50 ensures a contact between the plunger protrusion 24 and the barrel protrusion 50 at any rotational position of the plunger 12 relative to the barrel 14 and, as such, the generation of a detectable measurement signal.
  • the barrel protrusion length 54 is less than the circumference of the inner wall 48 of the barrel 14.
  • the barrel protrusion 50 may extend around the inner wall 48 of the barrel 14 in an interrupted form, having at least two segments. The segments may be equally or unequally spaced apart from one another.
  • a rotational locking mechanism may be provided to maintain a rotational position of the plunger 12 and the barrel 14 and to avoid bypassing of the plunger protrusion 24 and the barrel protrusion 50.
  • the rotational locking mechanism can prevent sliding of the plunger protrusion 24 in the space between the segments of the barrel protrusion 50.
  • the plunger protrusion length 28 can be greater than the spacing between the segments of the barrel protrusion 50.
  • one of the plunger protrusion 24 and the barrel protrusion 50 may have continuous circumferential form, and the other of the plunger protrusion 24 and the barrel protrusion 50 may have a segmented circumferential form.
  • the rotational locking mechanism may allow adjustment and locking of the plunger 12 and the barrel 14 in different rotational positions.
  • the plurality of plunger protrusions 24 are spaced from one another along the longitudinal axis 18 in a staggered configuration and form a plurality of plunger protrusion 24 columns along the plunger body 16.
  • Each column of plunger protrusions 24 may have different spacings 69 from one another, thereby providing the ability to measure in different volume intervals depending on the rotational position of the plunger 12 and the barrel 14.
  • the barrel protrusion body 52 extends from the inner wall 48 along a barrel protrusion height axis 60, the barrel protrusion height axis 60 being substantially transverse to the longitudinal axis 40 of the barrel 14.
  • the barrel protrusion height 58 is between about 0.02 mm and about 0.15 mm, between about 0.02 mm and about 0.12 mm, between about 0.02 mm and about 0.10 mm, between about 0.02 mm and about 0.08 mm, between about 0.02 mm and about 0.06 mm, between about 0.02 mm and about 0.04 mm, between about 0.04 mm and about 0.15 mm, between about 0.04 mm and about 0.12 mm, between about 0.04 mm and about 0.10 mm, between about 0.04 mm and about 0.08 mm, between about 0.04 mm and about 0.06 mm, between about 0.06 mm and about 0.15 mm, between about 0.06 mm and about 0.12 mm, between about 0.06 mm and about 0.10 mm, between about 0.06 mm and about 0.
  • the barrel protrusion width 72 is between about 0.4 mm and about 0.8 mm, between about 0.4 mm and about 0.7 mm, between about 0.4 mm and about 0.6 mm, between about 0.4mm and about 0.5 mm, between about 0.5 mm and about 0.8 mm, between about 0.5 mm and about 0.7 mm, between about 0.5 mm and about 0.6 mm, between about 0.6 mm and about 0.8 mm, between about 0.6 mm and about 0.7 mm, or between about 0.7 mm and about 0.8 mm.
  • the barrel protrusion width 72 is about 0.61 mm.
  • the radius of curvature of the arcuate form of the distal end 62 of the barrel protrusion 50 is between about 0.4 mm and about 0.8 mm, between about 0.4 mm and about 0.7 mm, between about 0.4 mm and about 0.6 mm, between about 0.4 mm and about 0.5 mm, between about 0.5 mm and about 0.8 mm, between about 0.5 mm and about 0.7 mm, between about 0.5 mm and about 0.6 mm, between about 0.6 mm and about 0.8 mm, between about 0.6 mm and about 0.7 mm, or between about 0.7 mm and about 0.8 mm.
  • the radius of curvature of the arcuate form of the distal end 62 of the barrel protrusion 50 is about 0.62 mm.
  • the plunger 12 and the barrel 14, as well as the plunger protrusion 24 and the barrel protrusion 50 are sized to contact one another at their respective contact faces when the plunger 12 is moved relative to the barrel 14 through a force applied in a first direction.
  • the continued applied force in the first direction causes the plunger protrusion 24 to slide past the barrel protrusion 50 and move from a pre-contact phase (FIG. 12 A), to a contact phase ( FIG. 12B) and to a post-contact phase (FIG. 12C) to thus to generate a given measurement signal when the plunger protrusion 24 clears the barrel protrusion 50.
  • Either compression or deformation of the plunger protrusion 24 or the barrel protrusion 50 or both allow for the transition from the pre-contact, to the post-contact phase. Furthermore, the position and size of the contact face on the plunger protrusion 24 and barrel protrusion 50 may vary as the plunger 12 slides from the pre-contact to the post-contact phase.
  • plunger protrusion 24 and barrel protrusion 50 may be sized and shaped to cause a hard stop when contacting one another at their respective contact faces when the plunger 12 is moved relative to the barrel 14 through a force applied in a first direction.
  • the plunger protrusion 24 does not slide past barrel protrusion 50 when continued force is applied in the first direction, thus indicating to the user that a given volume given volume of fluid appropriate to the fluid capacity of the syringe 10 has been aspirated or injected.
  • the magnitude and properties of the measurement signal are dependent on several factors associated with the design of the syringe 10. As well as the heights, 32, 58, widths 66,72, lengths 28,54, and radii of curvatures of the arcuate form of the distal ends 36, 62 of the plunger 12 and barrel 14 protrusions 24, 50, the magnitude of the measurement signal, in certain embodiments, is related to the extent of contact of the contact faces of the plunger protrusion 24 with the barrel protrusion 50. The extent of contact of the plunger protrusion 24 and barrel protrusion 50 can be defined in terms of an overlap ratio of the plunger protrusion 24 and the barrel protrusion 50.
  • the overlap ratio may be measured in terms of a portion of the plunger protrusion height 32 and the barrel protrusion height 58 which potentially impinge on one another when the plunger protrusion 24 and the barrel protrusion 50 are aligned.
  • the overlap ratio may also be expressed in terms of relatively impinging plunger and barrel protrusion widths 66, 72, lengths 28, 54, and radii of curvatures of the arcuate form of the distal ends 36, 62.
  • the overlap ratio may be expressed as a ratio or a percentage.
  • a greater overlap ratio means a greater magnitude of measurement signal, in certain embodiments.
  • the magnitude of the measurement signal is established by adjusting the barrel protrusion height 58 and plunger protrusion height 32.
  • the overlap ratio is calculated based on the ratio of the distance in chamber 42 over which the plunger protrusion 24 and barrel protrusion 50 heights 32, 58 overlap (d), divided by a distance between the plunger body 16 and the barrel body 38 in chamber 42 (D), expressed as a percentage, and is about 30%. This overlapping ratio generates both a tactile and audible signal by the syringe 10 when in use.
  • the magnitude of the measurement signal i.e. the hard stop
  • the overlap ratio calculated as above and expressed as a percentage is about 50%.
  • the overlap ratio calculated based on the barrel protrusion height 58 and plunger protrusion height 32 may be between about 20% and about 60%, between about 20% and about 50%, between about 20% and about 40%, between about 20% and about 30%, between about 30% and about 60%, between about 30% and about 50%, between about 30% and about 40%, between about 40% and about 60%, between about 40% and about 50%, or between about 50% and about 60%.
  • the overlap ratio calculated based on the barrel protrusion height 58 and plunger protrusion height 32 may be between about 60% and about 70%, between about 60% to about 65%, between about 65% to about 70%, or about 67.5%.
  • the overlap ratio calculated based on the barrel protrusion height 58 and plunger protrusion height 32 may be between about 5% to about 10%, or about 7.5%. In yet further embodiments, the overlap ratio may be increased by increasing the width and/or the radii of curvature of the arcuate form of the distal ends of the plunger protrusion 24, the barrel protrusion 50, or both.
  • the overlap factor may be increased to compensate for the effect of the fluid.
  • the material used to make the plunger protrusion 24 and barrel protrusion 50 also have an impact on the generation of the measurement signal by the syringe 10.
  • Materials with high compression properties may result in a damping effect on the magnitude of the measurement signal generated.
  • compression properties it is meant one or more of elastic modulus, tensile strength, compression strength, shear strength, and the like.
  • the magnitude of the measurement signal generated by the syringe 10 may be adapted with different material used to make the plunger protrusion 24 and barrel protrusion 50.
  • the plunger protrusion 24 and the barrel protrusion 50 are made of different materials having different compression properties.
  • Non-limiting examples of material used to make the plunger 12 and barrel 14 of the syringe 10 include, but are not limited to, polyethylene, polypropylene, cyclo-olefin polymer and copolymer, and the like.
  • material with low compression properties high rigidity may be used in the manufacture of the of the plunger 12 and the barrel 14 to prevent the plunger protrusion 24 and the barrel protrusion 50 moving past one another.
  • the material may be selected such that the syringe 10 may be sterilized.
  • FIG. 14A, and FIG. 16A there is shown embodiments of the syringe 10 of the present technology having a fluid capacity of 0.5 ml and 0.3 ml respectively.
  • the barrel 14 comprises a plurality of markings 74 on the outer wall 75 of the barrel body 38.
  • the spacing 76 between the plurality of the markings 74 corresponds to a 0.1 ml volume of fluid.
  • the barrel 14 may comprise the single marking 74 corresponding to the maximum volume of the fluid capacity of the syringe 10.
  • barrel 14 may comprise no markings 74 on the outer wall 75 of the barrel body 38 and measurement in such an embodiment is consequently made by tactile feedback only.
  • the inner wall 48 of the barrel 14, as seen in FIGS 14B and 16B, has the barrel protrusion 50 for engagement with the plunger protrusion 24 when the plunger 12 is received in the barrel 14 and moves relative to the barrel 14.
  • the barrel protrusion 50 is proximate the second open end 46 of the barrel 14, and is positioned between channel 41 and the flared portion 47 of the barrel 14.
  • the barrel protrusion 50 extends around the inner wall 48 in a continuous ring-like form such that the barrel protrusion length 54 is substantially the same as the circumference of the inner wall 48 of the barrel 14; the barrel protrusion height 58 is 0.15mm; and the barrel protrusion width 72 is 0.61mm.
  • the cross-sectional barrel protrusion profde 70 of the barrel protrusion body 52 has a symmetrical form and the barrel protrusion distal end 62 has an arcuate form with a radius of curvature of about 0.62mm.
  • the plunger 12 as seen in FIGS 14A & B, and 16A & B, comprises the single plunger protrusion 24 corresponding to 0.5ml and 0.3ml measurements of fluid respectively.
  • the single plunger protrusion 24 may correspond to 0.1, 0.2, 0.4 ml, 0.6 ml, 0.7 ml, 0.8 ml, 0.9 ml.
  • the plunger protrusion 24 comprises two segments extending circumferentially around the outer surface 20 of the plunger 12 on the same plane, substantially transverse to the longitudinal axis 18 of the plunger 12, and are equally spaced apart from one another (FIGS 14B and 16B).
  • the plunger protrusion 24 is spaced from the stopper protrusion 82 along the longitudinal axis 18 of the plunger 12 by the spacing 69 therebetween, the spacing 69 corresponding to a volume of fluid of 0.5 ml (FIG. 15 A).
  • spacing 69 may correspond to a volume of about 0.05 ml, about 0.1 ml, about 0.2 ml, about 0.3 ml (as in the embodiment of FIG. 16A & B), about 0.4 ml, about 0.5 ml, about 0.6 ml, about 0.7 ml, about 0.8 ml, or about 0.9 ml.
  • FIG. 15 A spacing 69 may correspond to a volume of about 0.05 ml, about 0.1 ml, about 0.2 ml, about 0.3 ml (as in the embodiment of FIG. 16A & B), about 0.4 ml, about 0.5 ml, about 0.6 ml, about 0.7 ml, about 0.8 ml,
  • the distance between the plunger protrusion 24 and the stopper protrusions 82 of the plunger 12, or the length of spacing 69 is 39.76mm; the plunger protrusion 26 comprises two segments, each segment having a segment length 29 of 2.44 mm; the plunger protrusion width 66 is 0.5mm; and the plunger protrusion height 32 is 0.15 mm.
  • the cross-sectional plunger protrusion profde 64 of the plunger protrusion 24 has an asymmetrical form, and is angular. In other embodiments, the cross-sectional plunger protrusion profde 64 may be symmetrical and have a plunger protrusion distal end 36 having an arcuate form.
  • the plunger body diameter 68 is about 4.15 mm, and the plunger protrusion height 32 is about 0.15 mm; the ratio of the diameter of the plunger body 68 to the plunger protrusion height 32 being about 28: 1.
  • the plunger protrusion 24 and barrel protrusion 50 are configured to cause a hard stop when contacting one another at their respective contact faces when the plunger 12 is moved in a direction away from the barrel 14 through an applied force.
  • the barrel protrusion height 58 and the plunger protrusion height 32 are configured such that the plunger protrusion 24 and the barrel protrusion 50 overlap when the plunger and the barrel are assembled such that the plunger protrusion 24 and the barrel protrusion 50 cannot be moved past each other.
  • the barrel protrusion height 58 and the plunger protrusion height 32 comprises about 50% of the distance between the plunger body 16 and the barrel body 38 in the chamber 42. This means that the plunger protrusion 24 and the barrel protrusion 50 cannot be moved past each other.
  • the overlap in the barrel protrusion height 58 and the plunger protrusion height 32 may comprise between about 20% to about 60%, between about 60% to about 70%, or between about 5% to about 10% of the distance between the plunger body 16 and the barrel body 38 in the chamber 42.
  • the plunger protrusion 24 and the barrel protrusion 50 are sized and shaped such that it is not possible to move them past each other on application of a reasonable force applied by the user.
  • the contact face of the plunger protrusion 24 and the barrel protrusion 50 are sized and shaped such that it is not possible to move them past each other on application of a reasonable force applied by the user. This in effect creates a maximum movement of the plunger relative to the barrel, on drawing fluid into the chamber 42, and hence a maximum volume of fluid that can be aspirated.
  • the shape and form of portion(s) of the outer surface 27 of the plunger protrusion 24 comprising the contact face for contacting the barrel protrusion 50, and the cross-sectional plunger protrusion profde 64 are is angular and has an asymmetrical so as to abut against the barrel protrusion 50 when the plunger 12 is moved out of the barrel 14 and to cause a hard stop.
  • any one or more of the heights, 32, 58, widths 66, 72, lengths 28, 54, radii of curvatures of the arcuate form of the distal ends 36, 62, or the shape and form of portion(s) of the outer surfaces 27, 53 and the cross-sectional profdes 64, 70 of the plunger 12 and barrel 14 protrusions 24, 50 may be adjusted such as to cause a hard stop when the plunger protrusion 24 and barrel protrusion 50 contact one another.
  • the outer surfaces 27, 53 and the cross-sectional profdes 64, 70 of the plunger protrusion 24 and the barrel protrusion 50 may be designed to have complementary shapes and to thereby lock into one another when the plunger 12 is moved out of chamber 42 of barrel 14 in order to cause a hard stop.
  • the plunger protrusion 24 does not slide past barrel protrusion 50 when continued force is applied, thus indicating to the user that the maximum fluid capacity of syringe 10 has been aspirated.
  • the plunger protrusion 24 and the barrel protrusion 50 may move relative to one another and slide past each other when continuous force is applied.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne une seringue comprenant un piston pouvant être reçu de façon coulissante dans un cylindre pour définir une chambre pour recevoir un fluide, et un mécanisme de signal de mesure comprenant des saillies correspondantes sur le piston et le cylindre qui sont agencés pour entrer en contact les uns avec les autres et pour générer un signal tactile et/ou audible lorsqu'ils sont amenés à coulisser l'un contre l'autre lorsque le piston est déplacé dans le cylindre et hors du cylindre, les saillies correspondantes ayant des faces de contact respectives qui entrent en contact les unes avec les autres lorsque le piston est déplacé par rapport au cylindre, et chacune des faces de contact respectives étant arrondie.
PCT/CA2020/051448 2019-10-28 2020-10-28 Seringue WO2021081643A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962927002P 2019-10-28 2019-10-28
US62/927,002 2019-10-28
US201962939482P 2019-11-22 2019-11-22
US62/939,482 2019-11-22
US202063085902P 2020-09-30 2020-09-30
US63/085,902 2020-09-30

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WO2021081643A1 true WO2021081643A1 (fr) 2021-05-06

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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076542A1 (fr) * 2001-02-28 2002-10-03 Mikael Hetting Seringue jetable
US20040010238A1 (en) * 2002-04-05 2004-01-15 Manera David A. Dispenser for medicaments and method and apparatus for making same
DE202005004079U1 (de) * 2005-03-14 2006-07-27 Transcoject Gesellschaft für medizinische Geräte mbH & Co. KG Injektionsspritze für medizinische Zwecke
WO2008016381A1 (fr) * 2005-12-21 2008-02-07 Algen & Klemer Llc Dispositifs de dosage
US20090287161A1 (en) * 2008-05-15 2009-11-19 Allergan, Inc Metered, multiple dose/aliquot syringe
US20110009829A1 (en) * 2009-07-10 2011-01-13 Becton, Dickinson And Company Flush Syringe Assembly
US20150141935A1 (en) * 2013-11-18 2015-05-21 Tessy Plastics Corporation Dispenser assembly for liquids comprising flexible barrel and rigid plunger
US20160022916A1 (en) * 2014-07-24 2016-01-28 Teleflex Medical Incorporated Dose Divider Syringe
US20160346480A1 (en) * 2015-05-15 2016-12-01 Jonathan L. Gleason Syringes and methods of using them to treat overactive bladder
US20180015227A1 (en) * 2015-01-27 2018-01-18 Omsi Sarl Plunger for syringes and syringes

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076542A1 (fr) * 2001-02-28 2002-10-03 Mikael Hetting Seringue jetable
US20040010238A1 (en) * 2002-04-05 2004-01-15 Manera David A. Dispenser for medicaments and method and apparatus for making same
DE202005004079U1 (de) * 2005-03-14 2006-07-27 Transcoject Gesellschaft für medizinische Geräte mbH & Co. KG Injektionsspritze für medizinische Zwecke
WO2008016381A1 (fr) * 2005-12-21 2008-02-07 Algen & Klemer Llc Dispositifs de dosage
US20090287161A1 (en) * 2008-05-15 2009-11-19 Allergan, Inc Metered, multiple dose/aliquot syringe
US20110009829A1 (en) * 2009-07-10 2011-01-13 Becton, Dickinson And Company Flush Syringe Assembly
US20110009830A1 (en) * 2009-07-10 2011-01-13 Becton, Dickinson And Company Flush Syringe Assembly with Controlled Pulsatile Flushing
US20150141935A1 (en) * 2013-11-18 2015-05-21 Tessy Plastics Corporation Dispenser assembly for liquids comprising flexible barrel and rigid plunger
US20160022916A1 (en) * 2014-07-24 2016-01-28 Teleflex Medical Incorporated Dose Divider Syringe
US20180015227A1 (en) * 2015-01-27 2018-01-18 Omsi Sarl Plunger for syringes and syringes
US20160346480A1 (en) * 2015-05-15 2016-12-01 Jonathan L. Gleason Syringes and methods of using them to treat overactive bladder

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