WO2021073659A3 - Vaccine vector prepared on basis of anionic polymers and derivatives thereof - Google Patents

Vaccine vector prepared on basis of anionic polymers and derivatives thereof Download PDF

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Publication number
WO2021073659A3
WO2021073659A3 PCT/CN2020/136150 CN2020136150W WO2021073659A3 WO 2021073659 A3 WO2021073659 A3 WO 2021073659A3 CN 2020136150 W CN2020136150 W CN 2020136150W WO 2021073659 A3 WO2021073659 A3 WO 2021073659A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
anionic polymers
basis
vaccine vector
vector prepared
Prior art date
Application number
PCT/CN2020/136150
Other languages
French (fr)
Chinese (zh)
Other versions
WO2021073659A2 (en
Inventor
孙逊
张志荣
龚涛
侯盈盈
白淑婷
Original Assignee
四川大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 四川大学 filed Critical 四川大学
Publication of WO2021073659A2 publication Critical patent/WO2021073659A2/en
Publication of WO2021073659A3 publication Critical patent/WO2021073659A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

A vaccine vector prepared on the basis of anionic polymers and derivatives thereof, and a preparation method therefor. Nanoparticles are compounded with an aluminum salt by means of a series of anionic polymers and derivatives thereof to form aluminum hydroxide. In the preparation process, different antigen components are added, and the antigens may be encapsulated. The prepared vaccine can effectively be absorbed by an antigen presenting cell and transmitted to a lymph node, and induce an antigen-specific immune response.
PCT/CN2020/136150 2019-10-14 2020-12-14 Vaccine vector prepared on basis of anionic polymers and derivatives thereof WO2021073659A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910970839.0A CN111658780B (en) 2019-10-14 2019-10-14 Vaccine vector prepared based on anionic polymer and derivatives thereof
CN201910970839.0 2019-10-14

Publications (2)

Publication Number Publication Date
WO2021073659A2 WO2021073659A2 (en) 2021-04-22
WO2021073659A3 true WO2021073659A3 (en) 2021-06-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/136150 WO2021073659A2 (en) 2019-10-14 2020-12-14 Vaccine vector prepared on basis of anionic polymers and derivatives thereof

Country Status (2)

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CN (1) CN111658780B (en)
WO (1) WO2021073659A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111658780B (en) * 2019-10-14 2021-10-12 四川大学 Vaccine vector prepared based on anionic polymer and derivatives thereof
CN112451659B (en) * 2020-11-30 2022-09-23 山东大学 Curdlan-quaternized chitosan conjugate nanoparticle as well as preparation method and application thereof
CN112957459B (en) * 2021-02-07 2022-10-28 天津大学 Tumor combined immune nano-particles based on influenza virus, preparation method thereof and application thereof in preparing nano-vaccine
CN113616799B (en) * 2021-07-13 2023-08-29 中国科学院长春应用化学研究所 Vaccine carrier, preparation method and application thereof
CN114129721B (en) * 2021-10-12 2024-05-07 江苏省农业科学院 Amphiphilic imiquimod grafted gamma-polyglutamic acid lauryl ester and application thereof
CN114028559A (en) * 2021-12-28 2022-02-11 广东粤港澳大湾区国家纳米科技创新研究院 Aluminum-manganese composite nanocrystalline and preparation method and application thereof
CN114569714B (en) * 2022-05-07 2022-07-29 北京生物制品研究所有限责任公司 Nano aluminium preparation and novel coronavirus inactivated vaccine prepared from same
CN114796480B (en) * 2022-06-09 2022-12-23 台州学院 Preparation method of composite nanoparticle aluminum adjuvant

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009053601A2 (en) * 2007-10-24 2009-04-30 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Method for preparing a vaccine composition comprising at least one antigen and at least one adjuvant
US20120095186A1 (en) * 2009-03-27 2012-04-19 Kagoshima University Polyion complex comprising hydrophobized polyamino acid and use of the same
CN104587464A (en) * 2015-01-23 2015-05-06 四川大学 Vaccine vector based on aluminum hydoxide nano-particles
CN111658617A (en) * 2019-10-14 2020-09-15 四川大学 Aluminum adjuvant-containing vaccine freeze-dried preparation and preparation method and application thereof
CN111658780A (en) * 2019-10-14 2020-09-15 四川大学 Vaccine vector prepared based on anionic polymer and derivatives thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009053601A2 (en) * 2007-10-24 2009-04-30 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Method for preparing a vaccine composition comprising at least one antigen and at least one adjuvant
US20120095186A1 (en) * 2009-03-27 2012-04-19 Kagoshima University Polyion complex comprising hydrophobized polyamino acid and use of the same
CN104587464A (en) * 2015-01-23 2015-05-06 四川大学 Vaccine vector based on aluminum hydoxide nano-particles
CN111658617A (en) * 2019-10-14 2020-09-15 四川大学 Aluminum adjuvant-containing vaccine freeze-dried preparation and preparation method and application thereof
CN111658780A (en) * 2019-10-14 2020-09-15 四川大学 Vaccine vector prepared based on anionic polymer and derivatives thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HANMEI LI, XUN SUN, DONG ZHAO, ZHIRONG ZHANG: "A Cell-Specific Poly(ethylene glycol) Derivative with a Wheat-like Structure for Efficient Gene Delivery.", MOLECULAR PHARMACEUTICS, vol. 9, no. 11, 8 September 2012 (2012-09-08), pages 2974 - 2985, XP055816912, ISSN: 1543-8384, DOI: 10.1021/mp300321n *
TOMOFUMI UTO; TAKAMI AKAGI; MASAAKI TOYAMA; YOSUKE NISHI; FUMIAKI SHIMA; MITSURU AKASHI; MASANORI BABA;: "Comparative activity of biodegradable nanoparticles with aluminum adjuvants: Antigen uptake by dendritic cells and induction of immune response in mice.", IMMUNOLOGY LETTERS, vol. 140, no. 1, 30 October 2011 (2011-10-30), pages 36 - 43, XP028268235, ISSN: 0165-2478, DOI: 10.1016/j.imlet.2011.06.002 *

Also Published As

Publication number Publication date
CN111658780B (en) 2021-10-12
CN111658780A (en) 2020-09-15
WO2021073659A2 (en) 2021-04-22

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