WO2021071319A1 - Protéine de fusion multispécifique et utilisation associée - Google Patents
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
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- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne une protéine de fusion multispécifique qui ne contient pas de région Fc et qui peut se lier particulièrement à deux antigènes ou plus. Dans un mode de réalisation, l'invention porte sur une protéine de fusion multispécifique comprenant les formules développées (I) et (II) ci-après : N'-A-L1-X-C' (I) ; et N'-B-L1-Y-C' (II). La protéine de fusion peut se lier à des cellules cancéreuses et à des cellules immuniitaires, et peut amplifier l'activité des cellules immunitaires. La protéine de fusion peut donc être utilisée comme agent anticancéreux.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2022004218A MX2022004218A (es) | 2019-10-10 | 2020-10-08 | Proteina de fusion multiespecifica y uso de la misma. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962913165P | 2019-10-10 | 2019-10-10 | |
| US62/913,165 | 2019-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2021071319A1 true WO2021071319A1 (fr) | 2021-04-15 |
Family
ID=75437505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2020/013805 WO2021071319A1 (fr) | 2019-10-10 | 2020-10-08 | Protéine de fusion multispécifique et utilisation associée |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR20210043475A (fr) |
| MX (1) | MX2022004218A (fr) |
| TW (1) | TW202128758A (fr) |
| WO (1) | WO2021071319A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11434291B2 (en) | 2019-05-14 | 2022-09-06 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013026837A1 (fr) * | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t. |
| WO2017134134A1 (fr) * | 2016-02-03 | 2017-08-10 | Amgen Research (Munich) Gmbh | ANTICORPS RECOMBINANTS BISPÉCIFIQUES BiTE (BISPECIFIC T CELL ENGAGING ANTIBODY) ANTI-BCMA ET ANTI-CD3 |
| KR20180016321A (ko) * | 2016-08-05 | 2018-02-14 | 주식회사 와이바이오로직스 | 프로그램화된 세포 사멸 단백질 리간드-1 (pd-l1)에 대한 항체 및 이의 용도 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3406633B1 (fr) | 2013-07-25 | 2022-03-02 | Cytomx Therapeutics Inc. | Anticorps multispécifiques, anticorps activables multispécifiques et leurs procédés d'utilisation |
-
2020
- 2020-10-08 KR KR1020200130525A patent/KR20210043475A/ko unknown
- 2020-10-08 WO PCT/KR2020/013805 patent/WO2021071319A1/fr active Application Filing
- 2020-10-08 MX MX2022004218A patent/MX2022004218A/es unknown
- 2020-10-12 TW TW109135226A patent/TW202128758A/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013026837A1 (fr) * | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t. |
| WO2017134134A1 (fr) * | 2016-02-03 | 2017-08-10 | Amgen Research (Munich) Gmbh | ANTICORPS RECOMBINANTS BISPÉCIFIQUES BiTE (BISPECIFIC T CELL ENGAGING ANTIBODY) ANTI-BCMA ET ANTI-CD3 |
| KR20180016321A (ko) * | 2016-08-05 | 2018-02-14 | 주식회사 와이바이오로직스 | 프로그램화된 세포 사멸 단백질 리간드-1 (pd-l1)에 대한 항체 및 이의 용도 |
Non-Patent Citations (2)
| Title |
|---|
| ADAM BATES, CHRISTINE A. POWER: "David vs. Goliath: The Structure, Function, and Clinical Prospects of Antibody Fragments", ANTIBODIES, vol. 8, no. 2, pages 28, XP055679798, DOI: 10.3390/antib8020028 * |
| ANONYMOUS: "Y-Biologics: utilizing innate assembly mechanismsin cell lines to create bispecific antibodies.", Y-BIOLOGICS, 1 September 2019 (2019-09-01), pages B8, XP055802100, Retrieved from the Internet <URL:https://media.nature.com/original/magazine-assets/d43747-020-00767-0/d43747-020-00767-0.pdf> [retrieved on 20210506] * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11434291B2 (en) | 2019-05-14 | 2022-09-06 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2022004218A (es) | 2022-07-19 |
| TW202128758A (zh) | 2021-08-01 |
| KR20210043475A (ko) | 2021-04-21 |
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