WO2021070962A1 - Gel d'électrode d'électrostimulation transcutanée, procédé d'électrostimulation transcutanée, dispositif d'électrostimulation vestibulaire et dispositif d'expérience de réalité virtuelle - Google Patents

Gel d'électrode d'électrostimulation transcutanée, procédé d'électrostimulation transcutanée, dispositif d'électrostimulation vestibulaire et dispositif d'expérience de réalité virtuelle Download PDF

Info

Publication number
WO2021070962A1
WO2021070962A1 PCT/JP2020/038396 JP2020038396W WO2021070962A1 WO 2021070962 A1 WO2021070962 A1 WO 2021070962A1 JP 2020038396 W JP2020038396 W JP 2020038396W WO 2021070962 A1 WO2021070962 A1 WO 2021070962A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
polymer
gel
electrical stimulation
host
Prior art date
Application number
PCT/JP2020/038396
Other languages
English (en)
Japanese (ja)
Inventor
英由樹 安藤
太嗣 北尾
琢朗 橋本
原田　明
義徳 ▲高▼島
基史 大▲崎▼
一真 青山
Original Assignee
国立大学法人大阪大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 国立大学法人大阪大学 filed Critical 国立大学法人大阪大学
Priority to JP2021551738A priority Critical patent/JPWO2021070962A1/ja
Publication of WO2021070962A1 publication Critical patent/WO2021070962A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/12—Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity
    • C08L101/14—Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
    • G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer

Definitions

  • Patent Document 1 discloses a method of presenting an acceleration that could be presented only in the left-right direction in multiple directions including left-right, front-back, up-down rotation, and such a method is a virtual reality: It is expected to be used in the VR) field.
  • VR virtual reality
  • GVS technology that can present virtual acceleration that matches the image in order to prevent so-called "VR sickness" due to the acceleration obtained from visual information and the acceleration in somatosensory not matching. Is desired to be constructed.
  • Electrode gel for bioelectric stimulation is known as an electrode gel for transcutaneous electrical stimulation, but since it is often used mainly for stimulating nerves for moving muscles, the tingling sensation is muscle. I don't feel any noticeable movement.
  • the electrode gel for transcutaneous electrical stimulation according to the present invention can suppress pain sensation during electrical stimulation.
  • the electrode gel for transcutaneous electrical stimulation of the present invention includes a "polymer gel” or a "xerogel".
  • the polymer gel is roughly classified into two types: a mode containing a “host-guest reversible crosslinked type” crosslinked polymer, which will be described later, and a mode containing a “movable crosslinked type” crosslinked polymer.
  • xerogels are roughly classified into two types: a mode containing a “host-guest reversible crosslinked type” crosslinked polymer, which will be described later, and a mode containing a “movable crosslinked type” crosslinked polymer.
  • the host group-containing polymerizable monomer examples include a compound in which the host group is bonded (particularly covalently bonded) to a vinyl compound having a functional group having radical polymerizable properties.
  • Ra, R H and R 1 are Ra of each formula (h1), and R H and R 1 synonymous.
  • n is an integer of 1 to 20, preferably 1 to 10, and more preferably 1 to 5.
  • Rb represents hydrogen or an alkyl group having 1 to 20 carbon atoms (preferably an alkyl group having 1 to 10 carbon atoms, more preferably an alkyl group having 1 to 6 carbon atoms).
  • (meth) acrylic means “acrylic” or “methacryl
  • (meth) acrylate means “acrylate” or “methacrylate”
  • (meth) allyl means “(meth) allyl”.
  • the structural unit having a guest group for example, a structural unit derived from a known polymerizable monomer containing a guest group (guest group-containing polymerizable monomer) can be widely applied.
  • the type of the guest group-containing polymerizable monomer is not particularly limited as long as it has a guest group and a functional group exhibiting polymerizable properties.
  • Specific examples of the functional group exhibiting polymerizable properties include -OH, -SH, -NH 2 , -COOH, -SO 3 H, -PO 4 H, isocyanate group, and epoxy group, in addition to alkenyl group and vinyl group. Glysidyl group) and the like.
  • the guest group-containing polymerizable monomer examples include a compound in which the guest group is bonded (particularly covalently bonded) to a vinyl compound having a functional group having radical polymerizable properties.
  • Examples of the guest group include a linear or branched hydrocarbon group having 3 to 30 carbon atoms, a cycloalkyl group, an aryl group, a heteroaryl group, an organic metal complex and the like, and these have one or more substituents. May be. More specific guest groups include chain or cyclic alkyl groups having 4 to 18 carbon atoms. The chain alkyl group having 4 to 18 carbon atoms may be either linear or branched. The cyclic alkyl group may have a cage-shaped structure.
  • substituents examples include halogen atoms (for example, fluorine, chlorine, bromine, etc.), hydroxyl groups, carboxyl groups, ester groups, amide groups, hydroxyl groups which may be protected, and the like, which are the same as the above-mentioned substituents. be able to.
  • halogen atoms for example, fluorine, chlorine, bromine, etc.
  • hydroxyl groups carboxyl groups, ester groups, amide groups, hydroxyl groups which may be protected, and the like, which are the same as the above-mentioned substituents. be able to.
  • Guest groups include, for example, alcohol derivatives; aryl compounds; carboxylic acid derivatives; amino derivatives; azobenzene derivatives having cyclic alkyl groups or phenyl groups; cinnamic acid derivatives; aromatic compounds and their alcohol derivatives; amine derivatives; ferrocene derivatives; Azobenzene; Naphthalene derivative; Anthracene derivative; Pyrene derivative: Perylene derivative; Clusters composed of carbon atoms such as fullerene; At least one selected from the group of dansyl compounds is one atom from a guest molecule (eg, hydrogen). A monovalent group formed by dividing an atom) can also be mentioned.
  • a guest molecule eg, hydrogen
  • guest group examples include a t-butyl group, an n-octyl group, an n-dodecyl group, an isobornyl group, an adamantyl group, and a group to which the substituent is bonded.
  • guest group-containing polymerizable monomer examples include a vinyl-based polymerizable monomer to which the guest group is bonded (hereinafter, may be referred to as “guest group-containing vinyl-based monomer”). be able to.
  • guest group-containing vinyl-based monomer a compound represented by the following general formula (g1) can be mentioned.
  • Ra represents a hydrogen atom or a methyl group
  • RG represents the guest group
  • R 2 is synonymous with R 1 in formula (h1).
  • (meth) acrylic acid ester or a derivative thereof that is, R 2 is -COO-
  • (meth) acrylamide or a derivative thereof that is, R 2 is-).
  • It is preferably CONH- or -CONR-, and R is synonymous with the above-mentioned substituent).
  • the polymerization reaction easily proceeds, the production of the polymer A becomes easy.
  • guest group-containing vinyl-based monomer examples include n-hexyl (meth) acrylate, n-octyl (meth) acrylate, n-dodecyl (meth) acrylate, adamantyl (meth) acrylate, and (meth).
  • Hydroxy adamantyl acrylate 1- (meth) acrylamide adamantan, 2-ethyl-2-adamantyl (meth) acrylate, N-dodecyl (meth) acrylamide, t-butyl (meth) acrylate, 1-acrylamide adamantan, N- (1-adamantyl) (meth) acrylamide, N-benzyl (meth) acrylamide, N-1-naphthylmethyl (meth) acrylamide, ethoxylated o-phenylphenol acrylate, phenoxypolyethylene glycol acrylate, isostearyl acrylate, nonylphenol EO adduct Examples thereof include acrylate and isobornyl (meth) acrylate.
  • the guest group-containing vinyl-based monomer can be produced by a known method. Further, as the guest group-containing polymerizable monomer, a commercially available product can also be used.
  • the polymer A can include the structural unit having the host group and the structural unit having the guest group, as well as the structural unit having neither the host group nor the guest group.
  • structural unit C a structural unit having neither a host group nor a guest group will be referred to as "structural unit C" below.
  • Examples of the polymerizable monomer C include various known vinyl-based polymerizable monomers.
  • Specific examples of the vinyl-based polymerizable monomer include a compound represented by the following general formula (a1).
  • the hydrogen atom of the carboxyl group is a hydrocarbon group having 1 to 20 carbon atoms, a hydroxyalkyl group (for example, a hydroxymethyl group, 1-). Hydroxyethyl group, 2-hydroxyethyl group), methoxypolyethylene glycol (the number of units of ethylene glycol is 1 to 20, preferably 1 to 10, particularly preferably 2 to 5), ethoxypolyethylene glycol (the number of units of ethylene glycol is 1 to 5). Examples thereof include a carboxyl group (that is, an ester) substituted with 1 to 20, preferably 1 to 10, particularly preferably 2 to 5) and the like.
  • the hydrocarbon group having 1 to 20 carbon atoms preferably has 1 to 15 carbon atoms, preferably 1 to 10 carbon atoms, and particularly preferably 1 to 3 carbon atoms.
  • the hydrocarbon group may be linear or branched.
  • R 3 when R 3 is an amide group having one or more substituents, that is, a secondary amide or a tertiary amide, one hydrogen atom or two hydrogens of the primary amide.
  • substituents that is, a secondary amide or a tertiary amide
  • examples thereof include an amide group in which atoms are independently substituted with a hydrocarbon group having 1 to 20 carbon atoms or a hydroxyalkyl group (for example, a hydroxymethyl group, a 1-hydroxyethyl group, or a 2-hydroxyethyl group).
  • the hydrocarbon group having 1 to 20 carbon atoms preferably has 1 to 15 carbon atoms, and preferably 2 to 10 carbon atoms.
  • the hydrocarbon group may be linear or branched.
  • the monomer represented by the formula (a1) include (meth) acrylic acid, allylamine, maleic anhydride, methyl (meth) acrylic acid, ethyl (meth) acrylic acid, and n- (meth) acrylic acid.
  • the polymerizable monomer C is preferably (meth) acrylic acid, (meth) acrylic acid ester, (meth) acrylamide or a derivative thereof. In this case, since the polymerization reaction easily proceeds, the production of the polymer A becomes easy.
  • the content ratio of the host group is not particularly limited.
  • the content ratio of the structural unit having a host group can be 0.01 to 10 mol% based on the total amount of the structural unit having a host group, the structural unit having a guest group, and the structural unit C.
  • the polymer A tends to form a host-guest reversible crosslinked polymer.
  • the content ratio of the structural unit having a host group is preferably 0.05 mol% or more, preferably 0.1 mol. % Or more, more preferably 0.2 mol% or more, and particularly preferably 0.5 mol% or more.
  • the content ratio of the structural unit having a host group is preferably 8 mol% or less, preferably 6 mol% or less, based on the total amount of the structural unit having a host group, the structural unit having a guest group, and the structural unit C. It is more preferably 5 mol% or less, and particularly preferably 4 mol% or less.
  • the molecular weight of the polymer A (for example, the weight average molecular weight) is not particularly limited, and can be, for example, in the same range as the molecular weight of the polymer compound obtained by general radical polymerization.
  • a solvent may be used in the polymerization reaction, or the solvent may not be used.
  • the type of solvent is not particularly limited.
  • the amount of the solvent used is also not particularly limited.
  • the polymer A has a host group and a guest group in its structural unit, so that the interaction between the host group and the guest group acts.
  • a so-called clathrate compound is formed in which one guest group is included in the ring of the host group in the polymer A.
  • the polymers A are crosslinked with each other, whereby the polymer A forms a "host-guest reversible crosslinked type" crosslinked polymer. Since the host-guest interaction is reversible, for example, when the polymer A is stressed, the host-guest interaction is canceled or the host-guest interaction occurs again.
  • examples of the polymerizable monomer C include compounds represented by the formula (a1), among which (meth) acrylic acid and (meth) acrylic acid ester (that is, R 2) are used. -COO-), (meth) acrylamide or a derivative thereof (that is, R 1 is -CONH- or -CONR-, and R is synonymous with the above-mentioned substituent).
  • R 1 is -CONH- or -CONR-
  • R is synonymous with the above-mentioned substituent
  • the polymerizable monomer C needs to be of a size capable of penetrating the inside of the ring of the host group, whereby the polymer B forms the above-mentioned "movable crosslinked" crosslinked polymer. It becomes possible to do. Therefore, the polymerizable monomer C is preferably (meth) acrylic acid, allylamine, maleic anhydride, methyl (meth) acrylate, (meth) acrylamide and the like.
  • the host group is preferably a group derived from ⁇ -cyclodextrin or a derivative thereof, or a group derived from ⁇ -cyclodextrin or a derivative thereof.
  • the polymer B may also contain a structural unit having a host group and other structural units other than the structural unit C as long as the effects of the present invention are not impaired.
  • the content of such other structural units is 5% by mass or less, preferably 1% by mass or less, more preferably 0.1% by mass or less, and particularly preferably 0.05, based on the total mass of the polymer B. It can be mass% or less.
  • the molecular weight of the polymer B (for example, the weight average molecular weight) is not particularly limited, and can be, for example, in the same range as the molecular weight of the polymer compound obtained by general radical polymerization.
  • the content ratio of each is not particularly limited, and the polymer B has the above-mentioned structure having the host group.
  • the content ratio of each polymerizable monomer can be adjusted so as to be the content ratio of the unit.
  • FIG. 1 is a diagram schematically illustrating a movable crosslinked type crosslinked polymer.
  • the movable crosslinked polymer has a crosslinked structure, that is, a three-dimensional network structure, and has a structure in which the polymer chain 30 penetrates the ring of the host group 10.
  • the polymer chain 30 corresponds to the polymer B.
  • the polymer chain 30 included in the host group needs to have a size capable of penetrating the inside of the ring of the host group.
  • Whether or not the polymer B forms a movable crosslinked type crosslinked polymer can be determined, for example, from the result of the swelling test of the polymer B. For example, when the polymer B is prepared without using a chemical cross-linking agent and the obtained polymer B is added to a solvent, the mobile cross-linked polymer shows a swelling phenomenon without being dissolved. It can be determined that it is formed, and when it is dissolved, it can be determined that the movable crosslinked polymer is not formed.
  • the polymer gel A contains a solvent A excluding the polymer A and glycerin.
  • the polymer A forms a "host-guest reversible crosslinked type" crosslinked polymer as described above. Therefore, in the polymer gel A, a guest group is included in the host group of the polymer A.
  • the host group of the polymer A is encapsulated with a guest group of another polymer A, which causes a host-guest interaction to form a crosslinked structure.
  • the aproton solvent examples include amides such as N, N-dimethylformamide, N-methylacetamide and N-methyl-2-pyrrolidone; esters such as methyl acetate and ethyl acetate, acetone, methyl ethyl ketone and ⁇ -butyrolactone.
  • ketones such as ( ⁇ BL), ethers such as 1,4-dioxane and tetrahydrofuran, sulfur-containing compounds such as dimethylsulfoxide, and carbonate compounds such as propylene carbonate.
  • the solvent A in the polymer gel A contains water.
  • the solvent A may be water alone.
  • the solvent in the polymer gel A may be water containing an inorganic salt or an organic molecule, and examples thereof include known buffer solutions.
  • the polymer B forms a "movable crosslinked" crosslinked polymer as described above. Therefore, in the polymer gel B, the polymer B has other polymers penetrating in the ring of the host group in a skewered manner. For example, as shown in FIG. 1, in the polymer gel B, a block portion formed by repeatedly arranging structural units C in another polymer B penetrates through the host group of the polymer B in a skewered manner. ..
  • the solvent B is not particularly limited, and for example, a well-known solvent that can be used for an electrode gel for a living body can be widely mentioned.
  • the solvent B include water, alcohol compounds having 1 to 3 carbon atoms (preferably ethanol and / or isopropanol), other organic compounds having a hydroxyl group, lipid oils, aprotic solvents, terpenoids, silicone oils, and the like.
  • Organic solvents can be mentioned.
  • examples of other organic compounds having a hydroxyl group include glycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol and the like.
  • aproton solvent examples include amides such as N, N-dimethylformamide, N-methylacetamide and N-methyl-2-pyrrolidone; esters such as methyl acetate and ethyl acetate, acetone, methyl ethyl ketone and ⁇ -butyrolactone.
  • ketones such as ( ⁇ BL), ethers such as 1,4-dioxane and tetrahydrofuran, sulfur-containing compounds such as dimethylsulfoxide, and carbonate compounds such as propylene carbonate.
  • the solvent B is preferably water, glycerin, or a mixed solvent thereof.
  • water and glycerin can be in any proportion.
  • the solvent B in the polymer gel B contains water, the solvent B may be water alone.
  • the solvent B in the polymer gel B contains water, the solvent B may be water containing an inorganic salt or an organic molecule, and examples thereof include known buffer solutions.
  • the content ratio of the solvent B contained in the polymer gel B is not particularly limited, and for example, the content ratio of the solvent B to the total mass of the polymer B and the solvent B can be 5 to 95% by mass, and 5 to 95% by mass. It is preferably 90% by mass, preferably 5 to 80% by mass, and even more preferably 5 to 70% by mass. In these cases, the electrode gel for transcutaneous electrical stimulation according to the present invention is less likely to cause pain during electrical stimulation.
  • the contents of the polymer B and the solvent B are, for example, 80% by mass or more, preferably 90% by mass or more, more preferably 95% by mass or more, and 99% by mass.
  • the above is particularly preferable.
  • the polymer gel A may be formed only of the polymer A and the solvent B.
  • the polymer gel A and the polymer gel B can contain other additives and the like as long as the effects of the present invention are not impaired.
  • the additive include a pH adjuster, a light stabilizer, an antioxidant, a preservative, a pigment, a colorant, an antifungal agent, a lubricant and the like.
  • the thickness of the polymer gel A and the polymer gel B is not particularly limited, and can be, for example, the same thickness as the known transcutaneous electrical stimulation electrode gel.
  • the thickness of the polymer gel A and the polymer gel B should be 0.05 to 5 mm from the viewpoint that when applied to human skin as an electrode gel for transcutaneous electrical stimulation, pain is less likely to be felt even when electrical stimulation is applied. Is preferable, and it is preferably 0.1 to 3 mm.
  • the resistance values of the polymer gel A and the polymer gel B are applied to the human skin from the viewpoint that, for example, when applied to the human skin as an electrode gel for transcutaneous electrical stimulation, pain is not easily felt even if an electrical stimulus is applied. It is preferable to have a resistance value close to each other, for example, it is preferably 800 to 5000 ⁇ , and more preferably 1000 to 3000 ⁇ .
  • the method for producing the polymer gel A and the polymer gel B is not particularly limited, and for example, the polymer gel A and the polymer gel B can be produced by the same method as a known method for producing a polymer gel.
  • the polymer gel A by selecting the solvent A as the solvent used when the polymer A is produced by the polymerization reaction, the polymer gel containing the polymer A and the solvent A can be obtained. Can be manufactured directly.
  • the polymer gel containing the polymer B and the solvent B is directly produced by selecting the solvent B as the solvent used when the polymer B is produced by the polymerization reaction. be able to.
  • the ratio of the polymer and the solvent in the polymer gel can be easily adjusted.
  • the electrode gel for transcutaneous electrical stimulation of the present invention includes xerogel as another aspect.
  • xerogels are roughly classified into two types: a mode containing a “host-guest reversible crosslinked type” crosslinked polymer and a mode containing a “movable crosslinked type” crosslinked polymer.
  • the xerogel contains polymer A
  • the xerogel contains polymer B.
  • the xerogel containing the polymer A will be referred to as a xerogel A
  • the polymer gel containing the polymer B will be referred to as a xerogel B.
  • xerogel A is a dried product of polymer gel A, xerogel A does not contain a solvent. Even if it is difficult to dry all the solvents in the polymer gel A and the solvent A remains, the content ratio of the solvent A is 5% by mass or less, preferably 3% by mass or less, based on the total amount of the xerogel. , More preferably 1% by mass or less, and particularly preferably 0.5% by mass or less.
  • the thicknesses of xerogel A and xerogel B are not particularly limited, and can be, for example, the same thickness as known transcutaneous electrical stimulation electrode gels.
  • the thickness of xerogel A and polymer gel B is preferably 0.001 to 1 mm from the viewpoint that pain is less likely to be felt even when electrical stimulation is applied. , 0.01 to 0.3 mm, more preferably 0.02 to 0.1 mm.
  • xerogel A and the polymer B contained in xerogel B have flexible and tough properties, so that although xerogels A and B are dried products, they are more than conventional chemically crosslinked gels. It is hard to break and has excellent toughness. Therefore, xerogel is an excellent material as an electrode gel for transcutaneous electrical stimulation.
  • the electrode gel for transcutaneous electrical stimulation is not particularly limited as long as it contains the polymer gel A or the polymer gel B, or as long as it contains the xerogel A or the xerogel B, and the other configurations are not particularly limited. It can have the same configuration as the electrode gel for use.
  • polymer gel A or polymer gel B can be combined with other materials and used as an electrode gel for transdermal electrical stimulation, or only polymer gel A or polymer gel B can be used for percutaneous electrical stimulation. It can be used as an electrode gel.
  • xerogel A or xerogel B and other materials can be combined and used as an electrode gel for transcutaneous electrical stimulation, or only xerogel A or xerogel B can be used as an electrode gel for transcutaneous electrical stimulation. ..
  • the "electrode gel for percutaneous electrical stimulation of the present invention” includes an electrode gel for percutaneous electrical stimulation containing the polymer gel A, an electrode gel for percutaneous electrical stimulation containing the polymer gel B, and xerogel A. Includes all electrode gels for percutaneous electrical stimulation, including electrode gels for skin electrical stimulation and xerogel B.
  • the electrode gel for transcutaneous electrical stimulation of the present invention can be suitably used as an electrode gel (biological electrode gel) used in a vestibular electrical stimulation device, a virtual reality experience device, or the like.
  • the vestibular electrical stimulator, the virtual reality experience device, and the like are not particularly limited in other configurations as long as the electrode gel for transcutaneous electrical stimulation of the present invention is provided.
  • the vestibular electrical stimulator can have the same other configurations as the known vestibular electrical stimulator as long as it includes the electrode gel for transcutaneous electrical stimulation of the present invention.
  • other configurations can be the same as those of the known virtual reality experience device.
  • the electrode gel for transdermal electrical stimulation of the present invention has improved electrical conductivity because the degree of freedom of the polymer chain network is improved by introducing reversible cross-linking or mobile cross-linking. It can be an electrode that is uniform and has appropriate conductivity. As a result, even if it is attached to human skin and given electrical stimulation, it is unlikely to induce pain.
  • hydrogels having a conventional chemically cross-linked structure have the characteristic that the cross-linking points between the polymer chains are covalently nationalized, and the electrical conductivity is non-uniform or too high. It is thought to cause pain.
  • the pain felt on human skin is reduced as compared with the conventional case even if electrical stimulation is applied, so that pain is a concern.
  • An electrical stimulator or a virtual reality experience device can be used without doing so.
  • pain sensation is induced at the time of stimulation, so in order to reduce the pain, stimulation is performed only with a weak current value that cannot obtain a sufficient effect on the target nerve tissue stimulation.
  • the method of applying transcutaneous electrical stimulation using the electrode gel for transcutaneous electrical stimulation of the present invention pain is reduced as described above, so that a sufficient effect can be obtained.
  • the current value can be used, and the stimulation position of the body part to be subjected to transcutaneous electrical stimulation is not easily restricted.
  • the electrode gel for transcutaneous electrical stimulation of the present invention is expected to have a wide range of applications such as leading to the development of new transcutaneous electrical stimulation.
  • GVS which generates virtual acceleration by electrical stimulation of the vestibular organ
  • the barriers to the introduction of GVS will be significantly reduced and the possibility of practical application will be greatly increased.
  • the introduction of the electrode gel for transcutaneous electrical stimulation of the present invention will lead to the widespread use and practical application of transcutaneous electrical stimulation such as tDCS and EMS.
  • the electrode gel for transcutaneous electrical stimulation of the present invention is extremely large in activating conventional industries such as entertainment, medical care, and welfare using transcutaneous electrical stimulation and in industrializing transcutaneous electrical stimulation itself. It can be said that this is an epoch-making technology that has an effect.
  • Example 1 2 mmol of 6-acrylamide methyl ⁇ -cyclodextrin (hereinafter referred to as “ ⁇ CDAAm, host group-containing polymerizable monomer)” represented by the following formula (7-1), and adamantyl acrylamide (AdAAm; guest group-containing polymerizable monomer).
  • ⁇ CDAAm 6-acrylamide methyl ⁇ -cyclodextrin
  • AdAAm adamantyl acrylamide
  • a mixture containing 2 mmol of monomer and water were mixed and then heated and stirred (60 ° C.) for a certain period of time to form an inclusion compound to obtain a colorless and transparent aqueous solution.
  • the amount of water used was adjusted so that the concentrations of ⁇ CDAAm and AdAAm were 2 mol / kg, respectively.
  • a sheet-shaped gel sample ( ⁇ CD-Ad-AAm (2,2)) was obtained by promptly pouring the mixture into a flat mold for the purpose of pursuing the polymerization reaction and holding the mixture at room temperature (25 ° C.) to proceed with the polymerization reaction.
  • the water content in the obtained gel sample was 82% by mass.
  • Example 2 A sheet-shaped gel sample ( ⁇ CD-Ad-AAm (2,2)) obtained by the same method as in Example 1 was allowed to stand in a well-ventilated place to dry it, and the amount of water in the gel sample was reduced. A gel sample having an amount of 32% by mass was obtained. At this time, the amount of water was finely adjusted by adding water by spraying or the like as appropriate.
  • Example 3 A sheet-shaped gel sample ( ⁇ CD-Ad) was prepared in the same manner as in Example 1 except that acrylamide (AAm) was changed to methoxy-triethylene glycol acrylate (TEGA, "Light Acrylate MTG-A” manufactured by Kyoeisha Chemical Co., Ltd.). -TEGA (2,2)) was obtained. Then, the obtained sheet-shaped gel sample was dried so that the water content was less than 5% by mass to obtain a xerogel sample ( ⁇ CD-Ad-TEGA (2,2)) having a thickness of 2 mm. It was.
  • acrylamide AAm
  • TEGA methoxy-triethylene glycol acrylate
  • Example 4 A sheet-shaped xero sample ( ⁇ CD-Ad-TEGA (2, 2)) in the same manner as in Example 3 except that the mold was changed to a flat mold for forming a sheet-shaped sample having a thickness of 0.1 mm. Got The thickness of the xerogel sample was 0.1 mm.
  • Example 5 A sheet-shaped xero sample ( ⁇ CD-Ad-HEA (2,2)) was obtained in the same manner as in Example 3 except that the methoxy-triethylene glycol acrylate (TEGA) was changed to hydrochiethyl acrylate (HEA). .. The thickness of the obtained xerogel sample was 2 mm.
  • Example 7 2 mmol of ⁇ CDAAm (host group-containing polymerizable monomer) and water were mixed to obtain an aqueous solution.
  • the amount of water used was adjusted so that the concentration of ⁇ CDAAm was 2 mol / kg.
  • 96 mmol of acrylamide (AAm; polymerizable monomer C) was added to the obtained aqueous solution, and the mixture was stirred to obtain a uniform solution.
  • 1 mol% of ammonium persulfoxide (APS) was added to the total amount of the polymerizable monomer, the solution was cooled to 0 ° C. and held, and 1 mol was further added to the total amount of the polymerizable monomer.
  • APS ammonium persulfoxide
  • % N, N, N, N-tetramethylethylenediamine was added to prepare the raw material.
  • the obtained raw material was quickly poured into a flat mold for forming a sheet-shaped sample having a thickness of 2 mm and held at room temperature (25 ° C.) to proceed with the polymerization reaction, and the sheet-shaped gel sample (sheet-shaped gel sample). ⁇ CD-AAm) was obtained.
  • the water content in the obtained gel sample was 82% by mass.
  • Example 8 A sheet-shaped gel sample ( ⁇ CD-AAm) was obtained in the same manner as in Example 7 except that the water was changed to glycerin. The amount of glycerin in the obtained gel sample was 82% by mass.
  • VAS Visual Evaluation Scale
  • the VAS was measured according to the following procedure. Behind the left and right ears of the subject, electrode samples molded into a mastoid process in a 2 mm square were brought into contact with each other and brought into close contact with each other using a fixture. A test was conducted in which a trapezoidal wave of a maximum of 2 mA was applied at 1 Hz for 10 seconds using a GVS constant current circuit, and the degree of skin irritation at the electrode contact portion at that time was answered. Specifically, the skin irritation was answered on a 10-point scale of the following ⁇ Pain Judgment Criteria>, and the pain symptoms, pain patterns, and pain locations were arbitrarily answered.
  • Tables 1 and 2 show the results of the VAS test of the gel samples obtained in each Example and Comparative Example.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Human Computer Interaction (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Photolithography (AREA)

Abstract

La présente invention concerne un gel d'électrode d'électrostimulation transcutanée avec lequel il est possible de supprimer la sensation de douleur pendant l'électrostimulation, et un procédé d'électrostimulation transcutanée qui utilise ledit gel d'électrode. La présente invention concerne également un dispositif d'électrostimulation vestibulaire et un dispositif d'expérience de réalité virtuelle qui sont équipés du gel d'électrode d'électrostimulation transcutanée.　La présente invention concerne un gel d'électrode d'électrostimulation transcutanée qui comprend un gel polymère, le gel polymère comprenant : un polymère A qui comprend une unité structurale ayant un groupe hôte ; et un solvant A autre que la glycérine. Le groupe hôte est un groupe monovalent dans lequel un atome d'hydrogène ou un groupe hydroxyle est retiré de la cyclodextrine ou d'un dérivé de celle-ci, et un groupe invité est reçu dans le groupe hôte du polymère A.
PCT/JP2020/038396 2019-10-11 2020-10-09 Gel d'électrode d'électrostimulation transcutanée, procédé d'électrostimulation transcutanée, dispositif d'électrostimulation vestibulaire et dispositif d'expérience de réalité virtuelle WO2021070962A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021551738A JPWO2021070962A1 (fr) 2019-10-11 2020-10-09

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019188135 2019-10-11
JP2019-188135 2019-10-11

Publications (1)

Publication Number Publication Date
WO2021070962A1 true WO2021070962A1 (fr) 2021-04-15

Family

ID=75438188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/038396 WO2021070962A1 (fr) 2019-10-11 2020-10-09 Gel d'électrode d'électrostimulation transcutanée, procédé d'électrostimulation transcutanée, dispositif d'électrostimulation vestibulaire et dispositif d'expérience de réalité virtuelle

Country Status (2)

Country Link
JP (1) JPWO2021070962A1 (fr)
WO (1) WO2021070962A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061218A1 (fr) * 1999-04-12 2000-10-19 Hisamitsu Pharmaceutical Co., Inc. Dispositif d'iontophorese et procede d'application de courant
US20020026219A1 (en) * 1998-09-09 2002-02-28 Collins James J. Galvanic vestibular stimulation system and method
JP2008188121A (ja) * 2007-02-01 2008-08-21 Nippon Telegr & Teleph Corp <Ntt> 電気刺激装置、刺激電流制御方法
JP2009522011A (ja) * 2005-12-30 2009-06-11 Ｔｔｉ・エルビュー株式会社 活性物質を生体界面に送達するイオントフォレーシスシステム、装置及び方法
WO2014054586A1 (fr) * 2012-10-02 2014-04-10 独立行政法人科学技術振興機構 Dispositif de détection de signal et procédé de détection de signal

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020026219A1 (en) * 1998-09-09 2002-02-28 Collins James J. Galvanic vestibular stimulation system and method
WO2000061218A1 (fr) * 1999-04-12 2000-10-19 Hisamitsu Pharmaceutical Co., Inc. Dispositif d'iontophorese et procede d'application de courant
JP2009522011A (ja) * 2005-12-30 2009-06-11 Ｔｔｉ・エルビュー株式会社 活性物質を生体界面に送達するイオントフォレーシスシステム、装置及び方法
JP2008188121A (ja) * 2007-02-01 2008-08-21 Nippon Telegr & Teleph Corp <Ntt> 電気刺激装置、刺激電流制御方法
WO2014054586A1 (fr) * 2012-10-02 2014-04-10 独立行政法人科学技術振興機構 Dispositif de détection de signal et procédé de détection de signal

Also Published As

Publication number Publication date
JPWO2021070962A1 (fr) 2021-04-15

Similar Documents

Publication Publication Date Title
Wang et al. Temperature-induced morphological transitions of poly (dimethylacrylamide)–poly (diacetone acrylamide) block copolymer lamellae synthesized via aqueous polymerization-induced self-assembly
Yeow et al. Polymerization-induced self-assembly using visible light mediated photoinduced electron transfer–reversible addition–fragmentation chain transfer polymerization
Suhail et al. Development and characterization of pH-sensitive chondroitin sulfate-co-poly (acrylic acid) hydrogels for controlled release of diclofenac sodium
Larnaudie et al. pH-Responsive, amphiphilic core–shell supramolecular polymer brushes from cyclic peptide–polymer conjugates
Pafiti et al. End-linked poly [2-(dimethylamino) ethyl methacrylate]–poly (methacrylic acid) polyampholyte conetworks: synthesis by sequential RAFT polymerization and swelling and SANS characterization
Rymaruk et al. RAFT dispersion polymerization in silicone oil
CA2546372A1 (fr) Hydrogels adhesifs electroconducteurs avec agent de solubilisation
US11254789B2 (en) Ionically modified silicones, compositions, and medical devices formed therefrom
Jo et al. RAFT homo-and copolymerization of N-acryloyl-morpholine, piperidine, and azocane and their self-assembled structures
Lee et al. Steric stabilization of thermally responsive N-isopropylacrylamide particles by poly (vinyl alcohol)
Kaldéus et al. All-aqueous SI-ARGET ATRP from cellulose nanofibrils using hydrophilic and hydrophobic monomers
Hebeish et al. Radically new cellulose nanocomposite hydrogels: Temperature and pH responsive characters
Banerjee et al. A muscle mimetic polyelectrolyte–nanoclay organic–inorganic hybrid hydrogel: its self-healing, shape-memory and actuation properties
Thompson et al. Preparation of biocompatible sterically stabilized latexes using well-defined poly (2-(methacryloyloxy) ethyl phosphorylcholine) macromonomers
Roy et al. Amino acid containing cross-linked co-polymer gels: pH, thermo and salt responsiveness
Deane et al. Synthesis of well-defined pyrrolidone-based homopolymers and stimulus-responsive diblock copolymers via RAFT aqueous solution polymerization of 2-(N-Acryloyloxy) ethylpyrrolidone
DE69821550T2 (de) Copolymer mit einer kationischen Gruppe und Verdickungsmittel
Kayalvizhy et al. Swelling behavior of poly (N-cyclohexylacrylamide-co-acrylamide/AMPSNa) gold nanocomposite hydrogels
WO2021070962A1 (fr) Gel d&#39;électrode d&#39;électrostimulation transcutanée, procédé d&#39;électrostimulation transcutanée, dispositif d&#39;électrostimulation vestibulaire et dispositif d&#39;expérience de réalité virtuelle
Costa et al. Swelling properties of cross-linked DNA gels
JP5939796B2 (ja) キチンまたはキトサンと合成高分子との複合体およびその製造方法
David et al. Rapid deswelling response of poly (N-isopropylacrylamide)/poly (2-alkyl-2-oxazoline)/poly (2-hydroxyethyl methacrylate) hydrogels
CN103333294B (zh) 一种高强度的抗蛋白质吸附水凝胶及其制备方法和应用
JP2015147856A (ja) 導電性ハイドロゲル
JP2000024672A (ja) 水溶性ポリマ―をベ―スにした水性分散体

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20874406

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2021551738

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20874406

Country of ref document: EP

Kind code of ref document: A1